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https://www.readbyqxmd.com/read/29662787/steroid-associated-osteonecrosis-animal-model-in-rats
#1
Li-Zhen Zheng, Jia-Li Wang, Ling Kong, Le Huang, Li Tian, Qian-Qian Pang, Xin-Luan Wang, Ling Qin
Objective: Established preclinical disease models are essential for not only studying aetiology and/or pathophysiology of the relevant diseases but more importantly also for testing prevention and/or treatment concept(s). The present study proposed and established a detailed induction and assessment protocol for a unique and cost-effective preclinical steroid-associated osteonecrosis (SAON) in rats with pulsed injections of lipopolysaccharide (LPS) and methylprednisolone (MPS). Methods: Sixteen 24-week-old male Sprague-Dawley rats were used to induce SAON by one intravenous injection of LPS (0...
April 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661601/corrigendum-to-evaluation-of-texture-analysis-parameter-for-response-prediction-in-patients-with-hepatocellular-carcinoma-undergoing-drug-eluting-bead-transarterial-chemoembolization-deb-tace-using-biphasic-contrast-enhanced-ct-image-data-correlation-with-liver
#2
Christopher Kloth, Wolfgang Maximilian Thaiss, Rainer Kärgel, Rainer Grimmer, Jan Fritz, Sorin Dumitru Ioanoviciu, Dominik Ketelsen, Konstantin Nikolaou, Marius Horger
No abstract text is available yet for this article.
April 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29613843/intraprocedural-ablation-margin-assessment-by-using-ammonia-perfusion-pet-during-fdg-pet-ct-guided-liver-tumor-ablation-a-pilot-study
#3
Paul B Shyn, Leigh C Casadaban, Nisha I Sainani, Cheryl A Sadow, Paul M Bunch, Vincent M Levesque, Chun K Kim, Victor H Gerbaudo, Stuart G Silverman
Purpose To prospectively determine whether nitrogen 13 (13 N) ammonia perfusion positron emission tomography (PET) during fluorine 18 fluorodeoxyglucose (FDG) PET/computed tomography (CT)-guided liver tumor ablation can be used to intraprocedurally assess ablation margins. Materials and Methods Eight patients (five women and three men; age range, 36-74 years; mean age, 57 years) were enrolled in this pilot study and underwent FDG PET/CT-guided microwave ablation of 11 FDG-avid liver metastases (mean diameter, 22 mm; range, 11-34 mm)...
April 3, 2018: Radiology
https://www.readbyqxmd.com/read/29602726/does-enhancement-or-perfusion-on-preprocedure-ct-predict-outcomes-after-embolization-of-hepatocellular-carcinoma
#4
Alessandra Borgheresi, Adrian Gonzalez-Aguirre, Karen T Brown, George I Getrajdman, Joseph P Erinjeri, Anne Covey, Hooman Yarmohammadi, Etay Ziv, Constantinos T Sofocleous, Franz Edward Boas
RATIONALE AND OBJECTIVE: The objective of this study was to evaluate whether quantitative enhancement or perfusion measurements on preprocedure triphasic computed tomography (CT) can be used to predict response or overall survival after embolization of hepatocellular carcinoma. MATERIALS AND METHODS: The institutional review board approved this retrospective review of 63 patients with hepatocellular carcinoma treated with particle embolization between March 2009 and December 2014...
March 27, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29531482/computed-tomography-perfusion-imaging-for-the-diagnosis-of-hepatic-alveolar-echinococcosis
#5
Recep Sade, Mecit Kantarci, Berhan Genc, Hayri Ogul, Betul Gundogdu, Omer Yilmaz
Objective: Alveolar echinococcosis (AE) is a rare life-threatening parasitic infection. Computed tomography perfusion (CTP) imaging has the potential to provide both quantitative and qualitative information about the tissue perfusion characteristics. The purpose of this study was the examination of the characteristic features and feasibility of CTP in AE liver lesions. Material and Methods: CTP scanning was performed in 25 patients who had a total of 35 lesions identified as AE of the liver...
February 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29520201/computed-tomographic-perfusion-imaging-for-the-prediction-of-response-and-survival-to-transarterial-chemoembolization-of-hepatocellular-carcinoma
#6
Peter Popovic, Ana Leban, Klara Kregar, Manca Garbajs, Rok Dezman, Matjaz Bunc
Background: The purpose of this retrospective cohort study was to evaluate the clinical value of computed tomographic perfusion imaging (CTPI) parameters in predicting the response to treatment and overall survival in patients with hepatocellular carcinoma (HCC) treated with drug-eluting beads transarterial chemoembolization (DEBTACE). Patients and methods: Between December 2010 and January 2013 eighteen patients (17 men, 1 woman; mean age 69 ± 5.8 years) with intermediate stage HCC underwent CTPI of the liver prior to treatment with DEBTACE...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#7
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29394753/-multidisciplinary-therapy-for-hepatocellular-carcinoma-with-peritoneal-dissemination
#8
Natsuko Yamauchi, Masahiro Kido, Shohei Komatsu, Motofumi Tanaka, Hisoka Kinoshita, Daisuke Tsugawa, Masafumi Awazu, Kimihiko Ueno, Hirochika Toyama, Sachio Terai, Hideyo Mukubou, Tetsuo Ajiki, Takumi Fukumoto
We report a case of bilobar multiple hepatocellular carcinoma(HCC)with peritoneal dissemination successfullytreated by dual treatment with reductive surgeryplus percutaneous isolated hepatic perfusion(PIHP). A 73-year-old man had sudden abdominal pain and was diagnosed bilobar multiple HCC through some examinations. The abdominal CT scan demonstrated onlya peritoneal dissemination under the liver. We performed partial hepatectomyof the lateral segment and the Spiegel lobe, and resected a peritoneal dissemination...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29386002/extended-left-hepatectomy-for-intrahepatic-cholangiocarcinoma-hepatic-vein-reconstruction-with-in-situ-hypothermic-perfusion-and-extracorporeal-membrane-oxygenation
#9
Deniz Balci, Menekse Ozcelik, Elvan Onur Kirimker, Arda Cetinkaya, Evren Ustuner, Mehmet Cakici, Bahadir Inan, Zekeriyya Alanoglu, Sadik Bilgic, Ahmet Ruchan Akar
BACKGROUND: Liver resection for intrahepatic cholangiocarcinoma (ICC) with invasion of the inferior vena cava (IVC) and hepatic veins (HV) is a challenging procedure. CASE PRESENTATION: We report a case of a 63-year-old woman with a 6-cm, centrally located liver mass. Her biochemistry results were normal except for a Ca19-9 level of 1199 U/ml. The liver biopsy was consistent with ICC and 60% macrosteatosis. Abdominal CT scans revealed a large central mass invading the left HV, middle HV and right HV, infringing on their junction with the vena cava...
January 31, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29380302/split-liver-technique-with-middle-hepatic-vein-reconstruction-on-livers-from-transplant-hepatectomies-a-useful-tool-for-surgical-improvement
#10
Raffaella Sguinzi, Fabio Ferla, Riccardo De Carlis, Enzo Andorno, Paolo Aseni, Luciano De Carlis
Livers removed during transplant hepatectomies could represent a useful anatomic ex vivo resource for surgical training, since they are intact and not altered by post-mortem changes yet. The aim of this study is to investigate the effectiveness of such kind of surgical training applied on some hepatic surgery techniques. In the present paper, we focused on split liver operation and middle hepatic vein (MHV) bipartition/reconstruction, since these procedures have a quite long learning curve. Seven native livers were submitted to split liver procedure by a senior resident assisted by a fully trained hepatic surgeon...
January 27, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29368273/modeling-of-the-contrast-enhanced-perfusion-test-in-liver-based-on-the-multi-compartment-flow-in-porous-media
#11
Eduard Rohan, Vladimír Lukeš, Alena Jonášová
The paper deals with modeling the liver perfusion intended to improve quantitative analysis of the tissue scans provided by the contrast-enhanced computed tomography (CT). For this purpose, we developed a model of dynamic transport of the contrast fluid through the hierarchies of the perfusion trees. Conceptually, computed time-space distributions of the so-called tissue density can be compared with the measured data obtained from CT; such a modeling feedback can be used for model parameter identification. The blood flow is characterized at several scales for which different models are used...
January 24, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29297607/signal-enhancement-ratio-imaging-of-the-lung-parenchyma-with-ultra-fast-steady-state-free-precession-mri-at-1-5t
#12
Orso Pusterla, Gregor Sommer, Francesco Santini, Mark Wiese, Didier Lardinois, Michael Tamm, Jens Bremerich, Grzegorz Bauman, Oliver Bieri
BACKGROUND: Lung perfusion MRI after i.v. gadolinium (Gd) contrast administration is commonly based on spoiled gradient-echo acquisitions, such as volume-interpolated breath-hold examinations (VIBE), suffering from low signal-to-noise in the parenchyma. PURPOSE: To investigate the lung signal enhancement ratio (SER) with ultra-fast steady-state free precession (ufSSFP) after Gd-administration. STUDY TYPE: Retrospective. SUBJECTS: Ten subjects with healthy lungs; nine patients with pulmonary diseases (chronic obstructive pulmonary disease [COPD], lung cancer, pulmonary fibrosis, lung contusion)...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29279169/hepatocellular-carcinoma-treated-with-sorafenib-arterial-tumor-perfusion-in-dynamic-contrast-enhanced-ct-as-early-imaging-biomarkers-for-survival
#13
Yuko Nakamura, Tomokazu Kawaoka, Toru Higaki, Wataru Fukumoto, Yukiko Honda, Makoto Iida, Chikako Fujioka, Masao Kiguchi, Hiroshi Aikata, Kazuaki Chayama, Kazuo Awai
OBJECTIVES: To investigate whether hepatic perfusion CT yields early imaging biomarkers predictive of the prognosis of hepatocellular carcinoma (HCC) patients treated with sorafenib. METHODS: We evaluated 36 HCC patients who underwent hepatic perfusion CT before- and one week after sorafenib therapy. We measured arterial and portal perfusion in the hepatic tumor and liver parenchyma [(AP)(PP)tumor ], [(AP)(PP)liver ]. The perfusion ratio was calculated by dividing the post- by the pre-sorafenib value...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29208767/the-feasibility-of-low-concentration-contrast-and-low-tube-voltage-in-computed-tomography-perfusion-imaging-an-animal-study
#14
Yuning Pan, Aiqin Song, Shizhong Bu, Zhaoqian Chen, Qiuli Huang, Aijing Li
Aim : To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging.Method : A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan...
February 28, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29191614/accuracy-of-a-cone-beam-ct-virtual-parenchymal-perfusion-algorithm-for-liver-cancer-targeting-during-intra-arterial-therapy
#15
Haytham Derbel, Hicham Kobeiter, Guillaume Pizaine, Fourat Ridouani, Alain Luciani, Alessandro Radaelli, William Van der Sterren, Mélanie Chiaradia, Vania Tacher
PURPOSE: To evaluate accuracy of virtual parenchymal perfusion (VPP) algorithm developed for targeting liver cancer during intra-arterial therapy (IAT) using cone-beam CT guidance. MATERIALS AND METHODS: VPP was retrospectively applied to 15 patients who underwent IAT for liver cancer. Virtual territory (VT) was estimated after positioning a virtual injection point on nonselective dual-phase (DP) cone-beam CT images acquired during hepatic arteriography at the same position chosen for selective treatment...
February 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29189398/quantification-of-the-effect-of-shuttling-on-computed-tomography-perfusion-parameters-by-investigation-of-aortic-inputs-on-different-table-positions-from-shuttle-mode-scans-of-lung-and-liver-tumors
#16
Payel Ghosh, Adam G Chandler, Brian P Hobbs, Jia Sun, John Rong, David Hong, Vivek Subbiah, Filip Janku, Aung Naing, Wen-Jen Hwu, Chaan S Ng
OBJECTIVES: The aim of this study was to quantify the effect of shuttling on computed tomography perfusion (CTp) parameters derived from shuttle-mode body CT images using aortic inputs from different table positions. METHODS: Axial shuttle-mode CT scans were acquired from 6 patients (10 phases, 2 nonoverlapping table positions 1.4 seconds apart) after contrast agent administration. Artifacts resulting from the shuttling motion were corrected with nonrigid registration before computing CTp maps from 4 aortic levels chosen from the most superior and inferior slices of each table position scan...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29153359/multi-detector-ct-liver-protocol-and-recent-developments
#17
REVIEW
N Kartalis, K Brehmer, L Loizou
Multi-detector computed tomography is today the workhorse in the evaluation of the vast majority of patients with known or suspected liver disease. Reasons for that include widespread availability, robustness and repeatability of the technique, time-efficient image acquisitions of large body volumes, high temporal and spatial resolution as well as multiple post-processing capabilities. However, as the technique employs ionizing radiation and intravenous iodine-based contrast media, the associated potential risks have to be taken into account...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29152431/intensity-modulated-proton-therapy-with-advanced-planning-techniques-in-a-challenging-hepatocellular-carcinoma-patient
#18
Smith Apisarnthanarax, Jatinder Saini, Avril O'Ryan-Blair, Jackie Castro, Stephen R Bowen
The use of radiation therapy has been increasing over recent years for the treatment of hepatocellular carcinoma (HCC). Proton beam therapy (PBT) has emerged as a promising treatment option for HCC patients due to its dosimetric advantages of sparing more normal liver tissue from radiation at low to moderate doses compared to photon-based treatments while still delivering high doses of radiation to tumors. The PBT therapy may be particularly beneficial in high-risk HCC cirrhotic patients with large, bulky tumors and/or vascular invasion complicated by surrounding perfusion abnormalities...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29124381/intraprocedural-3d-perfusion-measurement-during-chemoembolisation-with-doxorubicin-eluting-beads-in-liver-metastases-of-malignant-melanoma
#19
Philippe L Pereira, Kristina Krüger, Ernst Hohenstein, Florian Welke, Christof Sommer, Friedegund Meier, Thomas Eigentler, Claus Garbe
OBJECTIVES: To study feasibility and validity of a new software application for intraprocedural assessment of perfusion during chemoembolisation of melanoma metastases. METHODOLOGY: In a prospective phase-II trial, ten melanoma patients with liver-only metastases underwent chemoembolisation with doxorubicin-eluting beads (DEBDOX-TACE). Tumour perfusion was evaluated immediately before and after treatment at cone beam computer tomography (CBCT) using a new software application...
November 9, 2017: European Radiology
https://www.readbyqxmd.com/read/29113660/functional-hepatic-imaging-as-a-biomarker-of-primary-and-secondary-tumor-response-to-loco-regional-therapies
#20
REVIEW
H L Lewis, M A Ghasabeh, P Khoshpouri, I R Kamel, T M Pawlik
Objective criteria to measure tumor response are a key tenet for assessment of treatment efficacy when evaluating a therapeutic modality. Several response criteria have been proposed including the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), RECIST 1-1, and European Association for the Study of the Liver (EASL) guidelines. Response following loco-regional therapies (LRT) can be particularly difficult to assess as post-treatment changes may not always relate to changes in lesion size...
December 2017: Surgical Oncology
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