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https://www.readbyqxmd.com/read/27919850/detection-and-differentiation-of-early-hepatocellular-carcinoma-from-cirrhosis-using-ct-perfusion-in-a-rat-liver-model
#1
Jin-Ping Li, Guang-Long Feng, Da-Qing Li, Hai-Bo Wang, De-Li Zhao, Yong Wan, Hui-Jie Jiang
BACKGROUND: Functional imaging such as CT perfusion can detect morphological and hemodynamic changes in hepatocellular carcinoma (HCC). Pre-carcinoma and early HCC nodules are difficult to differentiate by observing only their hemodynamics changes. The present study aimed to investigate hemodynamic parameters and evaluate their differential diagnostic cut-off between pre-carcinoma and early HCC nodules using CT perfusion and receiver operating characteristic (ROC) curves. METHODS: Male Wistar rats were randomly divided into control (n=20) and experimental (n=70) groups...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27812781/ct-perfusion-for-early-response-evaluation-of-radiofrequency-ablation-of-focal-liver-lesions-first-experience
#2
Herman P Marquez, Gilbert Puippe, Rishi Philip Mathew, Hatem Alkadhi, Thomas Pfammatter, Michael A Fischer
PURPOSE: To investigate the value of perfusion CT (P-CT) for early assessment of treatment response in patients undergoing radiofrequency ablation (RFA) of focal liver lesions. METHODS AND MATERIALS: 20 consecutive patients (14 men; mean age 64 ± 14) undergoing P-CT within 24 h after RFA of liver metastases (n = 10) or HCC (n = 10) were retrospectively included. Two readers determined arterial liver perfusion (ALP, mL/min/100 mL), portal liver perfusion (PLP, mL/min/100 mL), and hepatic perfusion index (HPI, %) in all post-RFA lesions by placing a volume of interest in the necrotic central (CZ), the transition (TZ), and the surrounding parenchymal (PZ) zone...
November 3, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27801695/early-response-of-hepatocellular-carcinoma-to-chemoembolization-volume-computed-tomography-liver-perfusion-imaging-as-a-short-term-response-predictor
#3
Tian-Hao Su, Wen He, Long Jin, Guang Chen, Guo-Wen Xiao
OBJECTIVE: The aim of this study was to investigate the efficacy of lesion-oriented whole-liver computed tomography (CT) perfusion for predicting transarterial chemoembolization early treatment response in patients with hepatocellular carcinoma (HCC). METHODS: Volume helical shuttle CT perfusion imaging on the whole liver was prospectively performed on 39 patients with 46 independent HCC lesions before target-selected chemoembolization. The therapeutic effects were assessed: responder group included lesions with a complete and partial response, whereas the nonresponder group contained stable and progressive disease...
October 31, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27776665/image-quality-of-mean-temporal-arterial-and-mean-temporal-portal-venous-phase-images-calculated-from-low-dose-dynamic-volume-perfusion-ct-datasets-in-patients-with-hepatocellular-carcinoma-and-pancreatic-cancer
#4
X Wang, T Henzler, J Gawlitza, S Diehl, T Wilhelm, S O Schoenberg, Z Y Jin, H D Xue, A Smakic
PURPOSE: Dynamic volume perfusion CT (dVPCT) provides valuable information on tissue perfusion in patients with hepatocellular carcinoma (HCC) and pancreatic cancer. However, currently dVPCT is often performed in addition to conventional CT acquisitions due to the limited morphologic image quality of dose optimized dVPCT protocols. The aim of this study was to prospectively compare objective and subjective image quality, lesion detectability and radiation dose between mean temporal arterial (mTA) and mean temporal portal venous (mTPV) images calculated from low dose dynamic volume perfusion CT (dVPCT) datasets with linearly blended 120-kVp arterial and portal venous datasets in patients with HCC and pancreatic cancer...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27776657/vegfr-2-expression-in-hcc-dysplastic-and-regenerative-liver-nodules-and-correlation-with-pre-biopsy-dynamic-contrast-enhanced-ct
#5
W M Thaiss, S Kaufmann, C Kloth, K Nikolaou, H Bösmüller, M Horger
PURPOSE: To evaluate whether VEGFR-2-expression in hepatocellular carcinoma (HCC), dysplastic (DLN) and regenerative liver nodules (RLN) correlates with pre-histology, in vivo Dynamic Contrast Enhanced-Computed Tomography (DCE-CT) data as VEGFR-2-expression affects prognosis and therapeutic options. MATERIALS AND METHODS: 34 patients (63.6±8.9years, 7 females) underwent liver biopsy or surgery due to suspected HCC or dysplastic nodules after DCE-CT between 2009 and 2015 with no previous chemo- or interventional therapy...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27768066/long-term-high-resolution-intravital-microscopy-in-the-lung-with-a-vacuum-stabilized-imaging-window
#6
Carolina Rodriguez-Tirado, Takanori Kitamura, Yu Kato, Jeffery W Pollard, John S Condeelis, David Entenberg
Metastasis to secondary sites such as the lung, liver and bone is a traumatic event with a mortality rate of approximately 90% (1). Of these sites, the lung is the most difficult to assess using intravital optical imaging due to its enclosed position within the body, delicate nature and vital role in sustaining proper physiology. While clinical modalities (positron emission tomography (PET), magnetic resonance imaging (MRI) and computed tomography (CT)) are capable of providing noninvasive images of this tissue, they lack the resolution necessary to visualize the earliest seeding events, with a single pixel consisting of nearly a thousand cells...
October 6, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27759566/reproducibility-and-variability-of-very-low-dose-hepatic-perfusion-ct-in-metastatic-liver-disease
#7
Osman Melih Topcuoğlu, Muşturay Karçaaltıncaba, Deniz Akata, Mustafa Nasuh Özmen
PURPOSE: We aimed to determine the intra- and interobserver agreement on the software analysis of very low dose hepatic perfusion CT (pCT). METHODS: A total of 53 pCT examinations were obtained from 21 patients (16 men, 5 women; mean age, 60.4 years) with proven liver metastasis from various primary cancers. The pCT examinations were analyzed by two readers independently and perfusion parameters were noted for whole liver, whole metastasis, metastasis wall, and normal-looking liver (liver tissue without metastasis) in regions of interest (ROIs)...
November 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27745815/reproducibility-of-parenchymal-blood-volume-measurements-using-an-angiographic-c-arm-ct-system
#8
Kerstin Mueller, Rebecca Fahrig, Michael Manhart, Yu Deuerling-Zheng, Jarrett Rosenberg, Teri Moore, Arundhuti Ganguly, Nishita Kothary
RATIONALE AND OBJECTIVES: Intra-procedural measurement of hepatic perfusion following liver embolization continues to be a challenge. Blood volume imaging before and after interventional procedures would allow identifying the treatment end point or even allow predicting treatment outcome. Recent liver oncology studies showed the feasibility of parenchymal blood volume (PBV) imaging using an angiographic C-arm system. This study was done to evaluate the reproducibility of PBV measurements using cone beam computed tomography (CBCT) before and after embolization of the liver in a swine model...
October 10, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27730371/ptfe-graft-as-a-bridge-to-communicating-veins-maturation-in-the-treatment-of-an-intrahepatic-cholangiocarcinoma-involving-the-3-hepatic-veins-the-minor-but-complex-liver-resection
#9
Lucio Urbani, Riccardo Balestri, Francesco Sidoti, Juri Riccardo Bernardini, Francesco Arces, Gabriella Licitra, Chiara Leoni, Francesco Forfori, Piero Colombatto, Piero Boraschi, Maura Castagna, Piero Buccianti
BACKGROUND: Parenchyma-sparing liver surgery allows resecting hepatic veins (HV) at the hepatocaval confluence with minor (<3 adjacent segments) liver resections. PTFE graft can be used as a bridge to communicating-veins maturation to ensure the correct outflow of the spared liver. We present a video of an intrahepatic cholangiocarcinoma (IC) involving the three HV at the hepatocaval confluence treated with this approach. METHODS: In a 50-year old obese (BMI 44...
October 11, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27678134/haemodynamic-changes-in-hepatocellular-carcinoma-and-liver-parenchyma-under-balloon-occlusion-of-the-hepatic-artery
#10
Fumie Sugihara, Satoru Murata, Tatsuo Ueda, Daisuke Yasui, Hidenori Yamaguchi, Izumi Miki, Chiaki Kawamoto, Eiji Uchida, Shin-Ichiro Kumita
OBJECTIVES: To investigate haemodynamic changes in hepatocellular carcinoma (HCC) and liver under hepatic artery occlusion. METHODS: Thirty-eight HCC nodules in 25 patients were included. Computed tomography (CT) during hepatic arteriography (CTHA) with and without balloon occlusion of the hepatic artery was performed. CT attenuation and enhancement volume of HCC and liver with and without balloon occlusion were measured on CTHA. Influence of balloon position (segmental or subsegmental branch) was evaluated based on differences in HCC-to-liver attenuation ratio (H/L ratio) and enhancement volume of HCC and liver...
September 27, 2016: European Radiology
https://www.readbyqxmd.com/read/27646847/synthesis-and-evaluation-of-18-f-labeled-pyridaben-analogues-for-myocardial-perfusion-imaging-in-mice-rats-and-chinese-mini-swine
#11
Tiantian Mou, Zuoquan Zhao, Linyi You, Yesen Li, Qian Wang, Wei Fang, Jie Lu, Cheng Peng, Xianzhong Zhang
This study reports three novel (18)F-labeled pyridaben analogues for potential myocardial perfusion imaging (MPI). Three precursors and the corresponding nonradioactive compounds were synthesized and characterized. The radiolabeled tracers were obtained by substituting tosyl with (18)F. The total radiosynthesis time of these tracers was 70-90 min. Typical decay-corrected radiochemical yields were 47-58%, with high radiochemical purities (>98%). Tracers were evaluated as MPI agents in vitro, ex vivo and in vivo...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27610750/enhancing-the-role-of-paediatric-ultrasound-with-microbubbles-a-review-of-intravenous-applications
#12
Vasileios Rafailidis, Annamaria Deganello, Tom Watson, Paul S Sidhu, Maria E Sellars
Contrast-enhanced Ultrasound (CEUS) represents a complementary technique to grey-scale and colour Doppler ultrasonography (US) which allows for real-time visualization and characterization of tissue perfusion. Its inherent advantages in the child makes US an ideal imaging modality; repeatability and good tolerance along with the avoidance of computed tomography (CT), a source of ionizing radiation, renders US imaging desirable. Although currently paediatric CEUS is principally used in an "off-label" manner, US contrast agents have received regulatory approval for assessment of paediatric focal liver lesions in the United States of America...
September 9, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27596568/design-of-a-multimodal-1-h-23-na-mr-ct-anthropomorphic-thorax-phantom
#13
Wiebke Neumann, Florian Lietzmann, Lothar R Schad, Frank G Zöllner
OBJECTIVES: This work proposes a modular, anthropomorphic MR and CT thorax phantom that enables the comparison of experimental studies for quantitative evaluation of deformable, multimodal image registration algorithms and realistic multi-nuclear MR imaging techniques. METHODS: A human thorax phantom was developed with insertable modules representing lung, liver, ribs and additional tracking spheres. The quality of human tissue mimicking characteristics was evaluated for (1)H and (23)Na MR as well as CT imaging...
September 2, 2016: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/27577514/did-low-tube-voltage-ct-combined-with-low-contrast-media-burden-protocols-accomplish-the-goal-of-double-low-for-patients-an-overview-of-applications-in-vessels-and-abdominal-parenchymal-organs-over-the-past-5%C3%A2-years
#14
REVIEW
Yaqi Shen, Xuemei Hu, Xianlun Zou, Di Zhu, Zhen Li, Daoyu Hu
BACKGROUND: Imaging communities have already reached a consensus that the radiation dose of computed tomography (CT) should be reduced as much as reasonably achievable to lower population risks. Increasing attention is being paid to iodinated contrast media (CM) induced nephrotoxicity (CIN); a decrease in the intake of iodinated CM is required by increasingly more radiologists. Theoretically, the radiation dose varies with the tube current time and square of the tube voltage, with higher iodine contrast at low photon energies (Huda et al...
September 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27522708/-abdominal-radiology-in-oncology-the-new-trends-in-computed-tomography-and-magnetic-resonance-imaging
#15
REVIEW
A B Lukiyanchenko, V E Sinitsin, V O Panov
Paper gives a review of recent technical innovations in computed tomography (CT) and magnetic resonance imaging (MRI) that could be applied in abdominal oncology. Perfusion and dualenergy CT gives new opportunities for tissue characterization. Interactive reconstruction algorythms decrease radiation exposure to patients. Abdominal MRI has some important advantages over CT in detection and staging of abdominal malignancies. Nowadays standard MR protocols include DWI and dynamic 3D sequences with extracellular or liver-specific contrast media...
March 2016: Vestnik Rentgenologii i Radiologii
https://www.readbyqxmd.com/read/27522703/-extraosseous-abnormalities-and-artifacts-in-skeletal-scintigraphy
#16
S P Mironov, A A Ansheles, D N Shulgin, V B Sergienko
OBJECTIVE: to specify frequency, patterns and diagnostic significance of extraosseous soft tissue findings in 99mTc-pyrophosphate skeletal scintigraphy. MATERIAL AND METHODS: Results of skeletal scintigraphy from 1060 patients (447 men, 613 women) were analyzed. Scanning in "whole body" mode started in 3-4 hours after 740 MBq of radiotracer activity intravenous administration, and performed in anterior and posterior projections in continuous table motion mode at rate of 6-8 cm per minute...
March 2016: Vestnik Rentgenologii i Radiologii
https://www.readbyqxmd.com/read/27452478/analysis-of-iodinated-contrast-delivered-during-thermal-ablation-is-material-trapped-in-the-ablation-zone
#17
Po-Hung Wu, Chris L Brace
Intra-procedural contrast-enhanced CT (CECT) has been proposed to evaluate treatment efficacy of thermal ablation. We hypothesized that contrast material delivered concurrently with thermal ablation may become trapped in the ablation zone, and set out to determine whether such an effect would impact ablation visualization. CECT images were acquired during microwave ablation in normal porcine liver with: (A) normal blood perfusion and no iodinated contrast, (B) normal perfusion and iodinated contrast infusion or (C) no blood perfusion and residual iodinated contrast...
August 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27368924/arterio-portal-shunts-in-the-cirrhotic-liver-perfusion-computed-tomography-for-distinction-of-arterialized-pseudolesions-from-hepatocellular-carcinoma
#18
Michael A Fischer, Herman P Marquez, Sonja Gordic, Bertil Leidner, Ernst Klotz, Peter Aspelin, Hatem Alkadhi, Torkel B Brismar
OBJECTIVES: To determine perfusion computed tomography (P-CT) findings for distinction of arterial pseudolesions (APL) from hepatocellular carcinoma (HCC) in the cirrhotic liver. METHODS: 32 APL and 21 HCC in 20 cirrhotic patients (15 men; 65 ± 10 years), who underwent P-CT for evaluation of HCC pre- (N = 9) or post- (N = 11) transarterial chemoembolization, were retrospectively included using CT follow-up as the standard of reference. All 53 lesions were qualitatively (visual) and quantitatively (perfusion parameters) analysed according to their shape (wedge, irregular, nodular), location (not-/adjunct to a fistula), arterial liver perfusion (ALP), portal venous liver perfusion (PLP), hepatic perfusion index (HPI)...
July 1, 2016: European Radiology
https://www.readbyqxmd.com/read/27358139/effect-of-embolic-microspheres-in-the-treatment-of-primary-hepatic-carcinoma
#19
K B Wang, H Sui, W Li, L M Cui, B Bai
The purpose of this study was to evaluate the clinical effect of embolic microspheres in the treatment of primary hepatic carcinoma. Fifty-eight patients who were confirmed with primary hepatic carcinoma by imaging were retrospectively analyzed. They were firstly perfused with 50 mg of oxaliplatin and 40 mg of epirubicin. Embolic microspheres were then injected into the distal end of targeted blood vessels. After this procedure, dynamic observation was carried out until tumor stain disappeared. Liver function and blood indexes were reexamined on days 5, 6, 7 and 28 after treatment, and moreover, the liver was examined with Magnetic Resonance Imaging (MRI) or computed tomography (CT)...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27248430/quantitative-measurements-of-enhancement-on-preprocedure-triphasic-ct-can-predict-response-of-colorectal-liver-metastases-to-radioembolization
#20
F Edward Boas, Lynn A Brody, Joseph P Erinjeri, Hooman Yarmohammadi, Waleed Shady, Sirish Kishore, Constantinos T Sofocleous
OBJECTIVE: Colorectal liver metastases (CLM) have a variable response to radioembolization. This may be due at least partly to differences in tumor arterial perfusion. The present study examines whether quantitative measurements of enhancement on preprocedure triphasic CT can be used to predict the response of CLM to radioembolization. MATERIALS AND METHODS: We retrospectively reviewed patients with CLM treated with radioembolization who underwent pretreatment PET/CT and triphasic CT examinations and posttreatment PET/CT examinations...
September 2016: AJR. American Journal of Roentgenology
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