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https://www.readbyqxmd.com/read/30415888/etiology-clinical-course-and-outcome-of-infant-epilepsy-experience-of-a-tertiary-center-in-thailand
#1
Thitiporn Fangsaad, Siriluk Assawabumrungkul, Ponghatai Damrongphol, Tayard Desudchit
PURPOSE: Explore etiology, clinical course and outcome of infant epilepsy in Bhumibol Adulyadej Hospital. METHOD: Retrospective and prospective descriptive analysis of infants 1 month to 1 year diagnosed with epilepsy between January 1, 2012, and April 30, 2018. RESULTS: Total 57 infants. Average age of seizure onset was 4.7 months. Follow-up period averaged 34.2 months. Prenatal risk factors were found in 28.1 percent (16/57). Of these, 50 percent (8/16) had seizure in neonatal period...
November 8, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30384023/heart-rate-variability-in-neonatal-patients-with-seizures
#2
Rosario Statello, Luca Carnevali, Davide Alinovi, Francesco Pisani, Andrea Sgoifo
OBJECTIVE: Seizures are frequently observed in neurological conditions affecting newborns. Since autonomic alterations are commonly associated with neonatal seizures (NS), we investigated the utility of heart rate variability (HRV) indexes of cardiac autonomic regulation for NS detection. METHODS: HRV analysis was conducted on ECG tracings recorded during video-EEG monitoring in newborns with NS and matched-controls. The effects of gestational age on HRV were also evaluated...
October 25, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/30382869/symptomatic-seizures-in-preterm-newborns-a-review-on-clinical-features-and-prognosis
#3
REVIEW
Carlotta Spagnoli, Raffaele Falsaperla, Michela Deolmi, Giovanni Corsello, Francesco Pisani
Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular haemorrhage, hypoxic-ischemic encephalopathy, central nervous system infections and transient metabolic derangements.Current definition of neonatal seizures requires detection of paroxysmal EEG-changes, and in preterm newborns the incidence of electrographic-only seizures seems to be particularly high, further stressing the crucial role of electroencephalogram monitoring in this population...
November 1, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/30373414/seizures-in-newborn-infants-without-hypoxic-ischemic-encephalopathy-antenatal-and-labor-related-risk-factors-a-case-control-study
#4
Olle Malmqvist, Andreas Ohlin, Johan Ågren, Maria Jonsson
OBJECTIVE: To identify antepartum and intrapartum risk factors for neonatal seizures in the absence of hypoxic ischemic encephalopathy (HIE). METHODS: Population-based case-control study. Of 98 484 births, 40 newborns at 34 gestational weeks or later had seizures within the first 7 days of life. Cases (n = 40) and controls (n = 160) were retrieved from the University hospitals of Örebro for 1994-2013 and Uppsala for 2003-2013. Demographics and characteristics of pregnancy, labor, delivery, and neonatal data were analyzed...
October 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30350008/a-novel-intronic-homozygous-mutation-in-the-amt-gene-of-a-patient-with-nonketotic-hyperglycinemia-and-hyperammonemia
#5
Sarah Silverstein, Aravindhan Veerapandiyan, Caroline Hayes-Rosen, Xue Ming, Jeffrey Kornitzer
Nonketotic Hyperglycinemia is an autosomal recessive disorder characterized by defects in the mitochondrial glycine cleavage system. Most patients present soon after birth with seizures and hypotonia, and infants that survive the newborn period often have profound intellectual disability and intractable seizures. Here we present a case report of a 4-year-old girl with NKH as well as hyperammonemia, an uncommon finding in NKH. Genetic analysis found a previously unreported homozygous mutation (c.878-1 G > A) in the AMT gene...
October 22, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30346566/brat1-mutation-the-first-reported-case-of-chinese-origin-and-review-of-the-literature
#6
Randy H Van Ommeren, Andrew F Gao, Susan I Blaser, David A Chitayat, Lili-Naz Hazrati
Lethal neonatal rigidity and multifocal seizure syndrome (RMFSL) (OMIM#614498) is caused by homozygous or compound heterozygous mutation in the BRAT1 gene (OMIM#614506) on chromosome 7p22. We report a newborn female infant born to non-consanguineous Chinese parents who presented with hypertonia, dysmorphic features, progressive encephalopathy with refractory seizures, and worsening episodic apnea, leading to intubation and eventually death at 10 weeks of age. Whole exome sequencing revealed homozygous BRAT1 mutation, c...
October 20, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/30304906/the-clinical-characteristics-and-prognosis-of-subgaleal-hemorrhage-in-newborn
#7
Sun Jin Lee, Jin Kyu Kim, Sun Jun Kim
Purpose: Subgaleal hemorrhage (SGH) is a rare but potentially fatal condition in newborns; however, few studies have reported on this condition. We aimed to identify the clinical characteristics and prognostic factors of SGH. Methods: We retrospectively reviewed the medical records of 20 neonates diagnosed with SGH between January 2000 and June 2017. Enrolled neonates were clinically diagnosed when they had tender fluctuant scalp swelling that crossed the suture lines...
September 16, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30296665/a-comparison-of-levetiracetam-and-phenobarbital-for-the-treatment-of-neonatal-seizures-associated-with-hypoxic-ischemic-encephalopathy
#8
Lekha M Rao, Shaun A Hussain, Timothy Zaki, Alexander Cho, Teresa Chanlaw, Meena Garg, Raman Sankar
PURPOSE: Seizures are common in term infants with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia. Although phenobarbital (PHB) is generally considered first-line therapy, some centers have embraced third-generation antiepileptic drugs (AEDs) such as levetiracetam (LEV) given the impression of comparable efficacy and superior tolerability. We set out to compare the efficacy of PHB and LEV in a large single-center cohort. METHODS: We retrospectively identified consecutive newborns with HIE who were monitored with continuous video-electroencephalogram (VEEG) for the duration of therapeutic hypothermia...
October 5, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30293281/-diagnosis-and-treatment-of-five-neonatal-cerebral-venous-sinus-thrombosis
#9
Y Liu, D C Han, Y L Hu, L M Chen, J C Li, Y W Su, C X Hu
Objective: To summarize the clinical presentations and imaging features of cerebral venous sinus thrombosis (CVST) in 5 newborns. Methods: The clinical data of 5 newborns with CVST admitted to Department of Neonatology of Maternal and Children Hospital of Hubei Province from February 2017 to April 2018 were analyzed retrospectively. The risk factors, clinical presentations, imaging manifestations and treatment of CVST were investigated. Results: Of the 5 full term neonates, 4 were males and 1 female, with 4 aged less than 7 days and 1 more than 7 days; one with the history of maternal gestational diabetes mellitus, one with maternal gestational hypertension...
October 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30249623/childhood-seizures-after-phototherapy
#10
Thomas B Newman, Yvonne W Wu, Michael W Kuzniewicz, Barbara A Grimes, Charles E McCulloch
: media-1vid110.1542/5804915133001PEDS-VA_2018-0648 Video Abstract BACKGROUND AND OBJECTIVES: In a recent Danish study, researchers found an increased risk of childhood epilepsy after phototherapy but only in boys. We investigated this association in a Kaiser Permanente Northern California cohort. METHODS: From 499 642 infants born at ≥35 weeks' gestation in 1995-2011 followed for ≥60 days, we excluded 1773 that exceeded exchange transfusion thresholds and 1237 with seizure diagnoses at <60 days...
October 2018: Pediatrics
https://www.readbyqxmd.com/read/30246038/acute-life-threatening-hemorrhage-in-neonates-with-severe-hemophilia-a-a-report-of-3-cases
#11
Alvaro Moreira, Hrishikesh Das
Hemorrhagic shock is a rare, emergent condition that is often fatal in newborns. In this article, we report cases of 3 neonates presenting with acute, life-threatening hemorrhage who were subsequently diagnosed with severe hemophilia (<1% factor VIII). The first infant was tachycardic, pale, and had a precipitous drop in his hemoglobin secondary to a subgaleal hemorrhage. The second patient sustained a splenic rupture, a sequela that has been reported in only 4 other neonatal cases. The last infant presented with tonic-clonic seizures and respiratory distress...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/30236069/evaluation-of-the-efficacy-of-amplitude-integrated-electroencephalography-in-the-screening-of-newborns-with-metabolic-disorder-admitted-to-the-nicu
#12
Maliheh Kadivar, Ziba Mosayebi, Reza Shervin Badoo, Raziyeh Sangesari, Saeed Jedari Attari, Maryam Saeedi, Elahe Movahedi Moghadam
BACKGROUND: Neonate patients with metabolic disorder show encephalopathy and seizures that may lead to morbidity and mortality. Thus rapid detection and treatment of these patients is necessary. Although Amplitude-integrated electroencephalography (aEEG) has been used for more than a decade in the evaluation of infants with encephalopathy but has not been used in the assessment of neonates suffering from metabolic disorders. In this study, we tried to determine the efficacy of aEEG as an easily available diagnostic tool in the diagnosis of neonates with metabolic diseases...
September 20, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/30213441/severe-neurologic-and-hepatic-toxicity-in-a-newborn-prenatally-exposed-to-methamphetamine-a-case-report
#13
Eugenia Maranella, Arianna Mareri, Valentina Nardi, Cecilia Di Natale, Luisa Di Luca, Emanuela Conte, Veronica Pannone, Alessia Catalucci, Sandra Di Fabio
OBJECTIVE: In the recent years the increase of methamphetamines (MTA) abusers women has become an emerging problem. Very little data has been published regarding the effects of prenatal MTA exposure. We describe a case of MTA related toxicity in a term newborn which have early onset of neonatal encephalopathy and liver failure. CASE REPORT: A term infant born to a MTA abuser mother developed seizures and severe neurological symptoms shortly after birth. Methamphetamine was detected both in maternal and in neonatal urine...
September 10, 2018: Brain & Development
https://www.readbyqxmd.com/read/30149475/transplacental-lidocaine-intoxication
#14
V Demeulemeester, H V Hauthem, F Cools, J Lefevere
Neonatal seizures are frequent in neonatal intensive care and the most common cause is perinatal asphyxia. Among other causes, toxin exposure is rare.We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures. There was no hypoxic ischemic encephalopathy and brain imaging was normal. Toxicology screening revealed a toxic concentration of lidocaine in his blood. The intoxication was transplacental, as a cord blood sample confirmed the toxic level...
August 21, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/30132843/incidence-of-neonatal-seizures-perinatal-risk-factors-for-epilepsy-and-mortality-after-neonatal-seizures-in-the-province-of-parma-italy
#15
Francesco Pisani, Carlotta Facini, Elisa Bianchi, Giorgia Giussani, Benedetta Piccolo, Ettore Beghi
OBJECTIVE: Information about the incidence of neonatal seizures (NS) is scarce. Previous studies relied primarily on a clinical diagnosis of seizures. This population-based, retrospective study evaluated the incidence of electroencephalography (EEG)-confirmed seizures in neonates born in the province of Parma and the perinatal risk factors for mortality and epilepsy. METHODS: All neonates with suspected seizures or with medical conditions at high risk for seizures from the study area were recorded in the neonatal intensive care unit (NICU) of the Parma University Hospital...
September 2018: Epilepsia
https://www.readbyqxmd.com/read/30131764/a-model-of-perinatal-ischemic-stroke-in-the-rat-20-years-already-and-what-lessons
#16
REVIEW
Christiane Charriaut-Marlangue, Olivier Baud
Neonatal hypoxia-ischemia (HI) and ischemia are a common cause of neonatal brain injury resulting in cerebral palsy with subsequent learning disabilities and epilepsy. Recent data suggest a higher incidence of focal ischemia-reperfusion located in the middle cerebral artery (MCA) territory in near-term and newborn babies. Pre-clinical studies in the field of cerebral palsy research used, and still today, the classical HI model in the P7 rat originally described by Rice et al. (1). At the end of the 90s, we designed a new model of focal ischemia in the P7 rat to explore the short and long-term pathophysiology of neonatal arterial ischemic stroke, particularly the phenomenon of reperfusion injury and its sequelae (reported in 1998)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30123976/xenon-as-an-adjuvant-to-therapeutic-hypothermia-in-near-term-and-term-newborns-with-hypoxic-ischaemic-encephalopathy
#17
REVIEW
Christoph M Rüegger, Peter G Davis, Jeanie L Cheong
BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is a serious birth complication affecting term and late preterm newborns. Although therapeutic hypothermia (cooling) has been shown to be an effective therapy for neonatal HIE, many cooled infants have poor long-term neurodevelopmental outcomes. In animal models of neonatal encephalopathy, inhaled xenon combined with cooling has been shown to offer better neuroprotection than cooling alone. OBJECTIVES: To determine the effects of xenon as an adjuvant to therapeutic hypothermia on mortality and neurodevelopmental morbidity, and to ascertain clinically important side effects of xenon plus therapeutic hypothermia in newborn infants with HIE...
August 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30097625/dose-dependent-reversal-of-kcc2-hypofunction-and-phenobarbital-resistant-neonatal-seizures-by-ana12
#18
B M Carter, B J Sullivan, J R Landers, S D Kadam
Neonatal seizures have an incidence of 3.5 per 1000 newborns; while hypoxic-ischemic encephalopathy (HIE) accounts for 50-60% of cases, half are resistant to 1st-line anti-seizure drugs such as phenobarbital (PB). Tyrosine receptor kinase B (TrkB) activation following ischemic injury is known to increase neuronal excitability by downregulation of K-Cl co-transporter 2 (KCC2); a neuronal chloride (Cl- ) co-transporter. In this study, three graded doses of ANA12, a small-molecule selective TrkB antagonist, were tested in CD1 mice at P7 and P10 following induction of neonatal ischemia by a unilateral carotid ligation...
August 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30092488/leptin-regulated-autophagy-plays-a-role-in-long-term-neurobehavioral-injury-after-neonatal-seizures-and-the-regulation-of-zinc-cpla2-and-camk-ii-signaling-in-cerebral-cortex
#19
Li-Li Li, Ya-Chao Li, Dong-Jing Zhao, Mei-Fang Jin, Hong Ni
Metabolic disorders play an important role in the pathogenesis of many neurological diseases. Recent evidence suggests that leptin levels in peripheral blood and brain are lower in patients with epilepsy. Leptin is an energy-regulating hormone that plays a neuroprotective role in neurodegenerative diseases and brain trauma. However, little is known about the effects and molecular mechanisms of leptin treatment on long-term neurobehavioral impairment caused by developmental seizures. The present study evaluated whether chronic leptin treatment protected against neurobehavioral impairments induced by recurrent seizures in newborns treated with flurothyl...
October 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30083035/a-case-of-perinatal-hypophosphatasia-with-a-novel-mutation-in-the-alpl-gene-clinical-course-and-review-of-the-literature
#20
Maki Oyachi, Daisuke Harada, Natsuko Sakamoto, Kaoru Ueyama, Kawai Kondo, Kanako Kishimoto, Masafumi Izui, Yuiko Nagamatsu, Hiroko Kashiwagi, Miho Yamamuro, Makoto Tamura, Shin Kikuchi, Tomoyuki Akiyama, Toshimi Michigami, Yoshiki Seino, Noriyuki Namba
Hypophosphatasia (HPP) is a metabolic bone disease characterized by failure of bone calcification and vitamin B6 dependent seizures. It is caused by loss-of-function mutations in the ALPL gene. A newborn girl required respiratory support by nasal-directional positive airway pressure at birth, and pyridoxine hydrochloride administration for vitamin B6-dependent seizures observed from day two. Umbilical cord blood showed low alkaline phosphatase (ALP) activity and high pyridoxal phosphate levels. Radiographs showed severe rickets-like appearance of the bones...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
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