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seizures newborn

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https://www.readbyqxmd.com/read/30013074/gabrb2-knockout-mice-displayed-schizophrenia-like-and-comorbid-phenotypes-with-interneuron-astrocyte-microglia-dysregulation
#1
Rigil K Yeung, Zheng-Hua Xiang, Shui-Ying Tsang, Rui Li, Timothy Y C Ho, Qi Li, Chok-King Hui, Pak-Chung Sham, Ming-Qi Qiao, Hong Xue
Intronic polymorphisms of the GABAA receptor β2 subunit gene (GABRB2) under adaptive evolution were associated with schizophrenia and reduced expression, especially of the long isoform which differs in electrophysiological properties from the short isoform. The present study was directed to examining the gene dosage effects of Gabrb2 in knockout mice of both heterozygous (HT) and homozygous (KO) genotypes with respect to possible schizophrenia-like and comorbid phenotypes. The KO mice, and HT mice to a lesser extent, were found to display prepulse inhibition (PPI) deficit, locomotor hyperactivity, stereotypy, sociability impairments, spatial-working and spatial-reference memory deficits, reduced depression and anxiety, and accelerated pentylenetetrazol (PTZ)-induced seizure...
July 17, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30012112/maternal-and-infant-death-after-probable-vertical-transmission-of-chikungunya-virus-in-brazil-case-report
#2
Rhaquel de Morais Alves Barbosa Oliveira, Francisca Kalline de Almeida Barreto, Ana Maria Peixoto Cabral Maia, Ileana Pitombeira Gomes, Adriana Rocha Simião, Rebeca Bandeira Barbosa, Adilina Soares Romeiro Rodrigues, Kilma Wanderley Lopes, Fernanda Montenegro de Carvalho Araújo, Regina Lúcia Sousa do Vale, John Washington Cavalcante, Luciano Pamplona de Góes Cavalcanti
BACKGROUND: Chikungunya virus infection in neonates is relatively rare and can lead to death. CASE PRESENTATION: We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks' gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms...
July 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29961498/-cerebral-palsy-in-a-patient-with-arginase-deficiency
#3
Amanda Jichlinski, Lindsay Clarke, Matthew T Whitehead, Andrea Gropman
Inborn errors of metabolism (IEMs) are thought to present in infancy with acute decompensation including feeding intolerance and vomiting, lethargy, and coma. Most practitioners assume that children will be diagnosed in their first months of life. However, certain IEMs present more insidiously, and occasionally children fail to receive newborn screening resulting in delayed diagnoses, as metabolic and genetic disorders are overlooked causes of cognitive and neurologic deficits. Although signs and symptoms may be present but subtle, careful and detailed history taking, particularly of a child's diet and neurologic medical history, in addition to certain physical examination findings may suggest a diagnosis that is later supported by laboratory and radiographic testing...
July 2018: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29935542/clinical-evaluation-of-severe-neonatal-hyperbilirubinaemia-in-a-resource-limited-setting-a-4-year-longitudinal-study-in-south-east-nigeria
#4
Chidiebere D I Osuorah, Uchenna Ekwochi, Isaac N Asinobi
BACKGROUND: Neonatal hyperbilirubinaemia is one of the commonest causes of hospital visit in the neonatal period. When severe, it is a leading cause of irreversible neurological and musculoskeletal disability. Prompt recognition and timely interventions are imperative for a drastic reduction in complications associated with severe hyperbilirubinaemia in newborns. METHODS: We report a 4-year descriptive and longitudinal study to determine the causes, clinical presentations and long-term outcomes in newborns admitted for severe neonatal jaundice...
June 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29924224/subcutaneous-fat-necrosis-of-the-newborn-clinical-and-histopathological-correlation
#5
Guilherme Muzy, Silvia Assumpção Soutto Mayor, Rute Facchini Lellis
Subcutaneous fat necrosis of the newborn is a rare benign panniculitis found in term and post-term neonates. Diagnosis is based on clinical characteristics and specific alterations in the adipocytes, detected by anatomical pathology. Subcutaneous fat necrosis of the newborn can occur in uncomplicated pregnancy and childbirth. However, perinatal complications such as asphyxia, hypothermia, seizures, preeclampsia, meconium aspiration, and even whole-body cooling used in newborns with perinatal hypoxia/anoxia may be associated with this entity...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29889725/introduction-of-continuous-video-eeg-monitoring-into-2-different-nicu-models-by-training-neonatal-nurses
#6
Ipsita Goswami, Luis Bello-Espinosa, Jeffrey Buchhalter, Harish Amin, Alexandra Howlett, Michael Esser, Sumesh Thomas, Cathy Metcalfe, Jan Lind, Norma Oliver, Silvia Kozlik, Khorshid Mohammad
BACKGROUND: Continuous video electroencephalographic (EEG) (cvEEG) monitoring is emerging as the standard of care for diagnosis and management of neonatal seizures. However, cvEEG is labor-intensive and the need to initiate and interpret studies on a 24-hour basis is a major limitation. PURPOSE: This study aims at establishing consistency in monitoring of newborns admitted to 2 different neonatal intensive care units (NICUs) managed by the same neurocritical care team...
June 8, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29878631/midazolam-as-a-first-line-treatment-for-neonatal-seizures-retrospective-study
#7
Kim Dao, Eric Giannoni, Manuel Diezi, Eliane Roulet-Perez, Sebastien Lebon
Midazolam is commonly used to treat refractory seizures in newborns and as a first-line anti-epileptic drug in children. Its use as first-line treatment of neonatal seizures has not been investigated so far. We retrospectively studied the tolerability of midazolam in 72 newborn infants who received i.v. or i.n. midazolam as first-line treatment for seizures. No major side-effect exclusively due to midazolam was reported. The i.n. route was used for 20 patients (27.8%). Effectiveness could not be formally evaluated due to the absence of systematic electroencephalogram recording while midazolam was administered...
May 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29843267/impact-of-a-neuro-intensive-care-service-for-newborns
#8
M J Harbert, R Sey, K Arnell, L Salinda, M K Brown, D Lazarus, D M Poeltler, P R Wozniak, M R Rasmussen
BACKGROUND: Advances in treating the injured neonatal brain have given rise to neuro-intensive care services for newborns. This study assessed the impact of one such service in a cohort of newborns treated with therapeutic hypothermia. METHODS: Our newborn neuro-intensive care service was started in November 2012. From January 2008 to October 2016, a cohort of 158 newborns was treated with therapeutic hypothermia, 29 before and 129 after the inception of the service...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29775848/long-term-outcome-in-children-with-neonatal-seizures-a-tertiary-center-experience-in-cohort-of-168-patients
#9
Biljana Vucetic Tadic, Ruzica Kravljanac, Vlada Sretenovic, Vladislav Vukomanovic
PURPOSE: The purpose of this study was to evaluate long-term outcome and assess predictors of prognosis in children with neonatal seizures (NS). METHOD: This retrospective study includes children with NS treated at our Institute from January the 1st 2005 until December the 31st 2015. The data were collected from medical charts and the electroencephalogram (EEG) database at the Institute. The predictive value was evaluated for following parameters: (1) characteristics of the patients, such as gender, gestational age, birth body weight, Apgar score, artificial ventilation; (2) etiology; (3) characteristics of seizures such as type, time of onset, resistance to treatment; and (4) EEG background activity and paroxysmal discharges...
July 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29751353/zonisamide-serum-concentrations-during-pregnancy
#10
Arne Reimers, Grethe Helde, Noémi Becser Andersen, Dag Aurlien, Elisabeth Surlien Navjord, Kathrine Haggag, Jakob Christensen, Kari Mette Lillestølen, Karl Otto Nakken, Eylert Brodtkorb
PURPOSE: To investigate the change in zonisamide (ZNS) serum concentration and its consequences in pregnant women with epilepsy. METHODS: Six hospitals in Norway and Denmark screened their records for women who had been using ZNS during pregnancy. Absolute serum concentrations as well as concentration/dose (CD)-ratios were compared to non-pregnant values. Descriptive data on seizure control and obstetrical data were also collected. RESULTS: 144 serum concentrations from 23 pregnancies in 15 individual women with epilepsy were included (six on monotherapy)...
August 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29750802/severe-neonatal-hyperbilirubinemia-induces-temporal-and-occipital-lobe-seizures
#11
Lian Zhang
To examine the origin of seizures induced by severe neonatal hyperbilirubinemia, The EEG characteristics of seizures were analyzed in newborns with and without severe neonatal hyperbilirubinemia. Fisher's exact test was used to determine the specificity. In total, 931 patients had a total serum bilirubin (TSB) level of 340-425 μmol/L, only 2 of whom had seizures. Compared to patients with hyperbilirubinemia and a TSB level of 340-425 μmol/L, those with a TSB level >425 μmol/L had a significant risk of seizure (OR = 213...
2018: PloS One
https://www.readbyqxmd.com/read/29743770/paradoxical-reaction-to-midazolam-in-preterm-neonates-a-case-series
#12
Mahendra Kumar Gupta, Jayashree A Mondkar, Deepraj Hegde
Midazolam is a drug belonging to the benzodiazepine group and is used commonly for seizure control as well as preoperative and procedure-related sedation in neonates. Many adverse effects of midazolam have been reported in the past. Paradoxical stimulation of the central nervous system such as restlessness, nightmare, and hallucinations as well as hypomanic behavior has been reported in adults and children. Seizure is a rare adverse effect of midazolam. Cases of myoclonic movements associated with midazolam have been published worldwide; however, none so far have been reported from India...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29720158/a-systematic-review-comparing-neurodevelopmental-outcome-in-term-infants-with-hypoxic-and-vascular-brain-injury-with-and-without-seizures
#13
T R De Haan, J Langeslag, J H van der Lee, A H van Kaam
BACKGROUND: There is increasing evidence that neonatal seizures in term neonates with stroke, asphyxia or brain haemorrhage might be associated with adverse neurodevelopment and development of epilepsy. The extent of this association is not known. The objective of this study was to assess the possible impact of neonatal seizures on these outcomes and if possible calculate a relative risk. METHODS: A systematic review and meta-analysis was performed (study period January 2000-June 2015)...
May 2, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29702712/development-of-a-neuronicu-with-a-broader-focus-on-all-newborns-at-risk-of-brain-injury-the-first-2-years
#14
Krisa P Van Meurs, Elisabeth S Yan, Kathi S Randall, Valerie Y Chock, Alexis S Davis, Cecelia S Glennon, Catherine L Clark, Courtney J Wusthoff, Sonia L Bonifacio
OBJECTIVE:  Many critically ill neonates have an existing brain injury or are at risk of neurologic injury. We developed a "NeuroNICU" (neurologic neonatal intensive care unit) to better provide neurologically focused intensive care. STUDY DESIGN:  Demographic and clinical variables, services delivered, and patient outcomes were recorded in a prospective database for all neonates admitted to the NeuroNICU between April 23, 2013, and June 25, 2015. RESULTS:  In total, 546 neonates were admitted to the NeuroNICU representing 32% of all NICU admissions...
April 27, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29689584/bedside-ultrasound-guided-percutaneous-needle-aspiration-of-intra-and-extra-axial-intracranial-hemorrhage-in-neonates
#15
Mehmet N Cizmeci, Liesbeth Thewissen, Alexandra Zecic, Peter A Woerdeman, Bart de Boer, Edward Baert, Paul Govaert, Jeroen Dudink, Floris Groenendaal, Maarten Lequin, Linda S de Vries
Intracranial hemorrhage is an important cause of brain injury in the neonatal population and bedside percutaneous needle aspiration has emerged as an alternative due to the major risks that can be caused by standard neurosurgical decompression. We aimed to assess the effectiveness of this minimally invasive bedside technique and conducted a retrospective analysis of all newborn infants with a large extra-axial hemorrhage associated with a parenchymal hemorrhage causing a midline shift, managed at three academic centers over a 15-year period...
April 24, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29668332/neurological-complications-of-zika-virus-infection
#16
Francisco Javier Carod-Artal
Zika virus (ZIKV) disease is a vector-borne infectious disease transmitted by Aedes mosquitoes. Recently, ZIKV has caused outbreaks in most American countries. Areas covered: Publications about neurological complications of ZIKV infection retrieved from pubmed searchers were reviewed, and reference lists and relevant articles from review articles were also examined. Vertical/intrauterine transmission leads to congenital infection and causes microcephaly and congenital ZIKV syndrome. ZIKV preferentially infects human neural progenitor cells and triggers cell apoptosis...
May 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29663900/congenital-toxoplasmosis-in-tunisia-prenatal-and-neonatal-diagnosis-and-postnatal-follow-up-of-35-cases
#17
Yosr Boudaouara, Karim Aoun, Rania Maatoug, Olfa Souissi, Aïda Bouratbine, Rym Ben Abdallah
Congenital toxoplasmosis (CT) results from transplacental passage of Toxoplasma gondii to the fetus during acute maternal infection. Our study aims to report clinical and biological patterns of 35 cases of CT diagnosed at the department of the Parasitology of the Pasteur Institute of Tunis and to access the performance of prenatal and early postnatal diagnosis techniques. Serological screening of maternal infection was performed by Immunoglobulin (Ig) M and IgG detection and IgG avidity determination. Prenatal diagnosis was based on both Toxoplasma DNA detection in the amniotic fluid and monthly ultrasound examinations...
June 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29610328/ectopic-neurogenesis-induced-by-prenatal-antiepileptic-drug-exposure-augments-seizure-susceptibility-in-adult-mice
#18
Atsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, Kinichi Nakashima
Epilepsy is a neurological disorder often associated with seizure that affects ∼0.7% of pregnant women. During pregnancy, most epileptic patients are prescribed antiepileptic drugs (AEDs) such as valproic acid (VPA) to control seizure activity. Here, we show that prenatal exposure to VPA in mice increases seizure susceptibility in adult offspring through mislocalization of newborn neurons in the hippocampus. We confirmed that neurons newly generated from neural stem/progenitor cells (NS/PCs) are integrated into the granular cell layer in the adult hippocampus; however, prenatal VPA treatment altered the expression in NS/PCs of genes associated with cell migration, including CXC motif chemokine receptor 4 ( Cxcr4 ), consequently increasing the ectopic localization of newborn neurons in the hilus...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29600511/increased-cerebral-blood-flow-on-arterial-spin-labeling-magnetic-resonance-imaging-can-localize-to-seizure-focus-in-newborns-a-report-of-3-cases
#19
Patrick Mabray, Rapeepat Thewamit, Matthew T Whitehead, Amy Kao, Joseph Scafidi, William D Gaillard, Taeun Chang, Tammy N Tsuchida
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) can assess cerebral blood flow (CBF) without using radiolabeled tracers. It is unknown whether regional increases in CBF on ASL MRI correlate with seizure location in newborns. We report 3 newborns with focal seizures localized on continuous video electroencephalogram (cEEG), anatomical brain MRI, and ASL MRI. Each patient underwent pseudocontinuous ASL with segmented 3-dimensional fast spin echo readout as part of standard care. Case 1 is a term male infant presenting with left temporal status epilepticus and recurrent cEEG seizures from an idiopathic large left intraventricular hemorrhage...
May 2018: Epilepsia
https://www.readbyqxmd.com/read/29575911/t-2-mycotoxin-treatment-of-newborn-rat-pups-does-not-significantly-affect-nervous-system-functions-in-adulthood
#20
Petra Varró, Melinda Béldi, Melinda Kovács, Ildikó Világi
T-2 toxin is primarily produced by Fusarium sp. abundant under temperate climatic conditions. Its main harmful effect is the inhibition of protein synthesis. Causing oxidative stress, it also promotes lipid peroxidation and changes plasma membrane phospholipid composition; this may lead to nervous system alterations. The aim of the present study was to examine whether a single dose of T-2 toxin administered at newborn age has any long-lasting effects on nervous system functions. Rat pups were treated on the first postnatal day with a single intraperitoneal dose of T-2 toxin (0...
March 2018: Acta Biologica Hungarica
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