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gastric pathology

Hassan A Siddiki, Dora M Lam-Himlin, Allon Kahn, M Veronica Bandres, George E Burdick, Michael D Crowell, Rahul Pannala, Francisco C Ramirez, Marcelo F Vela, David E Fleischer
BACKGROUND AND AIMS: There is controversy about finding intestinal metaplasia (IM) of the gastric cardia on biopsy. The most recent American GI society guideline comments that IM cardia is not more common in patients with Barrett's. It provides limited guidance on whether the cardia should be treated when patients with Barrett's undergo endoscopic eradication therapy (EET) and whether the cardia should be biopsied after ablation. The aims of our study were to determine the frequency in the proximal stomach of (1) histologic gastric cardia mucosa and (2) IM cardia...
November 14, 2018: Gastrointestinal Endoscopy
Masayuki Shinkai, Motohiro Imano, Yasutaka Chiba, Mitsuru Iwama, Osamu Shiraisi, Atsushi Yasuda, Masanobu Tsubaki, Shozo Nishida, Yutaka Kimura, Takushi Yasuda
BACKGROUND: We carried out a phase II trial to evaluate the feasibility and efficacy of neoadjuvant chemotherapy comprising a single intraperitoneal administration of paclitaxel, followed by intravenous administrations of paclitaxel and cisplatin with S-1 for clinical stage III gastric cancer. METHODS: Patients with potentially resectable gastric cancer were eligible. A laparoscopic survey was performed to confirm CY0 and P0. Intraperitoneal paclitaxel (60 mg/m 2 ) was administered, followed by systemic chemotherapy...
November 15, 2018: Journal of Surgical Oncology
Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha, Sung Hoon Noh
BACKGROUND: With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following chemotherapy for patients with stage IV gastric cancer. METHODS: We retrospectively reviewed clinico-pathologic variables and oncologic outcomes for 101 patients with stage IV gastric cancer who were treated with systemic chemotherapy followed by gastrectomy with intension of curative resection from January 2005 to December 2012...
November 15, 2018: BMC Cancer
Dhouha Bacha, Marwa Walha, Sana Ben Slama, Haifa Ben Romdhane, Saadia Bouraoui, Khadija Bellil, Ahlem Lahmar
Chronic gastritis are inflammatory diseases of the gastric mucosa whose diagnosis depends on  pathological examination. They are frequent and cover a significant part of the daily activity of pathologists. Their origin is often infectious, particularly by Helicobacter Pylori. Several classifications of chronic gastritis were proposed but in order to achieve standardization in the drafting of pathological reports of gastric biopsies, pathologists currently following the recommendations of the revisted Sydney System...
July 2018: La Tunisie Médicale
Xin Chen, Dina Kamel, Braden Barnett, Evan Yung, Adrienne Quinn, Caroline Nguyen
There has been an increasing awareness of post gastric bypass hypoglycemia (PGBH). Histopathologic findings from such patients who underwent partial/total pancreatomy, however, can vary widely from minimal changes to classic nesidioblastosis, making the pathologic diagnosis challenging. PGBH typically presents as postprandial hypoglycemia, as opposed to insulinoma, which presents as fasting hypoglycemia. Herein, we describe an unusual case of a patient with PGBH who initially presented with postprandial hypoglycemia three years after surgery, but later developed fasting hyperinsulinemic hypoglycemia as the disease progressed...
October 31, 2018: Endocrinology, Diabetes & Metabolism Case Reports
Xi Cheng, Shan Yu, Yan Wang, Yuehong Cui, Wei Li, Yiyi Yu, Cheng Tang, Huiqin Jiang, Yuan Ji, Yihong Sun, Xuefei Wang, Zhenbin Shen, Fenglin Liu, Tian-Shu Liu
BACKGROUND: To compare the efficacy of oxaliplatin-based and oxaliplatin-free adjuvant chemotherapies in patients with different Lauren type gastric cancers after D2 gastrectomy. METHODS: From our established gastric cancer database, patients with pathological stage II and III gastric cancer who received adjuvant chemotherapy after D2 gastrectomy at Zhongshan Hospital of Fudan University were analyzed. Patients who received different adjuvant chemotherapy regimens were divided into two subgroups: oxaliplatin-based and oxaliplatin-free subgroup...
November 13, 2018: Gastric Cancer
W Y Gu, X Tao, L L Zhang, L Wang, X R Zhou, Y Ning
Objective: To describe the clinicopathological features of synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT). Methods: The sample consisted of 7 cases of SMMN-FGT recorded from November 2014 to September 2017 at Obstetrics and Gynecology Hospital, Fudan University.PAP method was used in immunohistochemistry.Clinical histories were retrieved and pathological slides were reviewed. Results: The patients were 37 to 70 years old(mean 54 years old). All patients showed endometrial mucinous lesions associated with cervical lesions...
November 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
D Huang, Z S Li, X S Fan, H M Wu, J P Liu, W Y Sun, S S Li, Y Y Hou, X Nie, J Li, R Qin, L C Guo, J H Xu, H Z Zhang, M M Sun, Q N Guo, Y H Yang, Y H Liu, Y Qin, L J Zhang, J H Li, Z H Zhang, P Gao, Y J Li, W Q Sheng
Objective: To investigation HER2 status in gastric adenocarcinoma of Chinese and contributing factors to the HER2 expression. Methods: HER2 status of 40 842 gastric adenocarcinomas and clinical data were retrospectively collected from 23 hospitals dated from 2013 to 2016. The association between HER2 positivity and clinicopathologic features was analyzed. Results: Of the 40 842 patients the median age was 62 years, the male female ratio was 2.6∶1.0. The rate of HER2 positivity was 8.8% (3 577/40 842). HER2 expression was related to the tissue type, tumor location, Lauren classification and tumor differentiation ( P values: 0...
November 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Hina Yousuf, Hafiz M Kashif Saleem, Muhammad Arslan Arif Maan, Nadeem A Chaudhary
The paradigm for the diagnosis and management of gastric cancer is changing with advanced diagnostic and therapeutic interventions. Prior gastric surgery (20 years or more) is one of the risk factors for gastric cancer. Increased intragastric carcinogen formation is thought to contribute toward gastric cancer development in the remaining portion of the stomach. This case illustrates the importance of a thorough clinical and pathologic workup and highlights the advanced technique of single-balloon enteroscopy (SBE) and its role in managing patient's health...
September 4, 2018: Curēus
P A Boonstra, N Steeghs, S Farag, F van Coevorden, H Gelderblom, D J Grunhagen, I M E Desar, W T A van der Graaf, J J Bonenkamp, A K L Reyners, B van Etten
BACKGROUND: A cohort of 201 patients with small bowel gastrointestinal stromal tumors (GIST) treated between January 1st, 2009 and December 31st, 2016 in five GIST expertise centers in the Netherlands was analyzed. Goal of this study was to describe the clinical, surgical and pathological characteristics of this rare subpopulation of GIST patients, registered in the Dutch GIST registry. METHODS: Clinical outcomes and risk factors of patients with small bowel GIST who underwent surgery or treated with systemic therapy were analyzed...
October 16, 2018: European Journal of Surgical Oncology
Nobuhiko Nakagawa, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database. METHODS: We retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014...
November 8, 2018: Cancer Medicine
Tomoyuki Okumura, Yasuyuki Seto, Susumu Aikou, Makoto Moriyama, Shinich Sekine, Isaya Hashimoto, Kazuto Shibuya, Shozo Hojo, Isaku Yoshioka, Takuya Nagata, Tsutomu Fujii
We herein report a case of mediastinoscopic salvage esophagectomy for recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy in a previously pneumonectomized patient. A 66-year-old man with a medical history of left-sided pneumonectomy for lung cancer was diagnosed with local recurrence of lower esophageal squamous cell carcinoma (cT3N0M0 cStage II) 9 years after definitive chemoradiotherapy. The mediastinoscopic cervical approach and laparoscopic transhiatal approach were combined, and the thoracic esophagus was safely mobilized to separate the esophagus from the stump of the left bronchus and to divide dense adhesions between the esophagus and fibrotic tissue at the site of the previous left mediastinal pleural resection...
November 8, 2018: Asian Journal of Endoscopic Surgery
Kohei Wakatsuki, Sohei Matsumoto, Kazuhiro Migita, Tomohiro Kunishige, Hiroshi Nakade, Shintaro Miyao, Masayuki Sho
PURPOSE: We assessed the prognostic value of the fibrinogen-to-platelet ratio (FPR) as an inflammatory and coagulative index by examining its clinicopathologic and prognostic efficiency in patients with gastric cancer (GC). METHODS: The subjects of this retrospective study were 182 GC patients whose FPR was measured preoperatively between January, 2001 and December, 2006. The FPR was defined as the plasma fibrinogen divided by the platelet counts. RESULTS: Patients aged ≥ 65 years and with venous invasion had a significantly higher FPR (p = 0...
November 8, 2018: Surgery Today
Fengping Li, Jiaolong Shi, Zhijun Xu, Xingxing Yao, Tingyu Mou, Jiang Yu, Hao Liu, Guoxin Li
Driver genes conducing to peritoneal metastasis in advanced gastric cancer remain to be clarified. S100A4 is suggested to evolve in metastasis of gastrointestinal cancer, we aim to explore the role of S100A4 plays in metastasis of advanced gastric cancer and the potential mechanism. Transfection of siRNA or cDNA was applied to alter the expression of protein S100A4 and MYH9, investigation of the expression of epithelial and mesenchymal transition (EMT) associated markers was followed. Cell migration assay was used to screen the alteration of migration ability regulated by S100A4 and MYH9...
2018: Journal of Cancer
Cheng Tang, Xi Cheng, Shan Yu, Yan Wang, Jun Hou, Qian Li, Zhenbin Shen, Tianshu Liu, Yuehong Cui
Background: Many studies have discussed the relationship between routine blood parameters and the prognosis of gastric cancer patients; however, few studies focused on the association of routine blood parameters with the efficacy of neoadjuvant chemotherapy (NAC). Patients and methods: We retrospectively collected routine blood parameters and other clinicopathological data of 104 patients with locally advanced gastric cancer (LAGC) who received the oxaliplatin and capecitabine regimen as NAC from June 2010 to March 2016...
2018: OncoTargets and Therapy
Tong Zhang, Yunfeng Shi, Yanqing Zhao, Jianying Wang, Minjia Wang, Bing Niu, Qin Chen
BACKGROUND: Peanut allergy is one of the most common food allergies worldwide. Studies have shown that the incidence of peanut allergies in Western-born Asians is higher than that in Asia-born Asians. Notably, Europeans and Americans mostly eat roasted peanuts, whereas Asians mostly eat boiled or fried peanuts. RESULTS: BALB/c mice were sensitized using purified protein from raw, roasted or boiled peanuts, then fed the same by oral gavage. The relevant allergic reactions were studied using BALB/c mice model, including a Rat Basophilic Leukemia (RBL) cell model, simulated gastric fluid experiments, and ultraviolet (UV) and Circular Dichroism (CD) spectrum analysis...
November 8, 2018: Journal of the Science of Food and Agriculture
Menghui Wu, Tianyu Zhou, Donghui Cao, Limei Qu, Xueyuan Cao
RATIONALE: Glomus tumors (GTs) are a rare disorder originating from the glomus of the anastomoses of small arteries, usually occurring in the subungual region of the fingertips or toes and seldom occurring in the stomach. We unintentionally found a case of a gastric glomus tumor (GGT) without any upper abdominal discomfort. The diagnosis of this disease was mainly by immunohistochemistry. PATIENT CONCERNS: The patient presented to our hospital with intermittent right abdominal pain for 1 month...
November 2018: Medicine (Baltimore)
Junjun Li, Bingbing Hu, Lei Fang, Yang Gao, Shuai Shi, Haoyu He, Xiaomei Liu, Caijun Yuan
China is a country with a high incidence of gastric cancer (GC), where the GC incidence and the resultant mortality rates account for 50% of those worldwide. Surgical resection remains the primary treatment for GC. However, postoperative patients have a poor prognosis as the majority of patients present with metastases at the time of diagnosis. Therefore, the identification of novel treatment targets is required. The present study aimed to determine the effects of barrier-to-autointegration factor 1 (BANF1) on the clinical features and prognosis of GC, which may aid in discovering a novel tumor diagnostic biomarker and treatment target...
November 2018: Oncology Letters
Xuetao Dong, Yandi Liu
Clinical significance of micro ribonucleic acid (miR)-24 and miR-101 were investigated by evaluating the expression of miR-24 and miR-101 in the tissues of patients with advanced gastric cancer. A total of 247 gastric cancer tissue specimens and 150 cancer-adjacent normal tissues (>5 cm away from the tumor) from patients with advanced gastric cancer who underwent surgical resection in the Surgical Oncology Department of Tianjin Union Medical Centre (Tianjin, China) from April 2013 to May 2016 were collected...
November 2018: Oncology Letters
Ying Gao, Zhicai Xu, Fei Yuan, Minglei Li
BACKGROUND The aim of this study was to explore the expression levels of micro ribonucleic acid-10b (miR-10b) and micro ribonucleic acid-181b (miR-181b) in gastric cancer tissues, as well as their application value in clinical diagnosis and treatment. MATERIAL AND METHODS A total of 120 patients with gastric cancer who were diagnosed and treated in the Department of Gastroenterology of our hospital were enrolled in this study. The gastric cancer tissues and paracancerous tissues were collected for measuring the expression of miR-10b and miR-181b by in situ hybridization and reverse transcription-polymerase chain reaction (RT-PCR)...
November 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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