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gastric pathology

Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Laila Bouguenouch, Karima El Rhazi, Mohamed El Abkari, Chakib Nejjari, Mustapha Mahmoud, Bahia Bennani
BACKGROUND: The pathogenicity of cagA-positive H. pylori strains is associated with the number and type of repeated sequences named EPIYA located in the C-terminal region of the CagA protein. The aim of this study is to determine the polymorphism of the H. pylori cagA 3' region circulating in Morocco and its association with different gastric pathologies. METHODS: A total of 1353 consenting patients, were recruited in this study. The gastric biopsies performed during endoscopy were used for histological examination and for molecular characterization of H...
September 19, 2018: Infection, Genetics and Evolution
Sabine Roman, François Mion
Pharmacologic therapy, surgery, minimally invasive therapies, and alternative therapies are different options available for the management of refractory GERD. The choice may depend on the cause of refractoriness. Increased gastric acid suppression therapy might be useful in the rare patients with persistent elevated esophageal acid exposure on proton pump inhibitors (PPI). Potassium-competitive acid blockers (P-CAB) might induce a more important acid inhibition than PPI. Baclofen might act as a reflux inhibitor and demonstrates a significant efficacy in rumination syndrome...
September 18, 2018: Current Opinion in Pharmacology
Masayuki Urabe, Tetsuo Ushiku, Aya Shinozaki-Ushiku, Akiko Iwasaki, Sho Yamazawa, Hiroharu Yamashita, Yasuyuki Seto, Masashi Fukayama
Adenocarcinoma of the esophagogastric junction (AEG) has heterogeneous carcinogenic process due to its location straddling the esophagogastric junction. We assessed background mucosal pathology and its correlation with clinicopathological features of each Siewert type of AEG. Clinicopathological and immunohistochemical analyses of 103 AEGs and 58 gastric cancers (GCs) were conducted. Background mucosal features were evaluated according to the updated Sydney System. Siewert classification divided 103 AEGs into three type I, 75 type II, and 25 type III tumors, respectively...
September 21, 2018: Cancer Medicine
Min Chen, Huishu Yuan
We report the case of a 54-year-old man with 6 months of progressive sacral pain. Computed tomography showed a large osteolytic mass in the sacrum with multiple osteolytic foci in the ilium and lumbar spine. Magnetic resonance imaging revealed multiple fluid-fluid levels in the sacral lesion as well as in the lumbar foci. The multiple bone lesions were initially diagnosed as a primary sacral malignancy with multiple bone metastases. A biopsy of the sacral lesion under the guidance of computed tomography was performed and a metastatic adenocarcinoma from the stomach or lung was found pathologically...
September 20, 2018: Skeletal Radiology
Kanako Nishiyama, Yoshiaki Kamei, Erina Kusakabe, Haruna Yamasawa, Reina Aoki, Saaya Komatsu, Kana Taguchi, Akari Murakami, Michiko Yamashita
Case 1 involved a 75-year-old woman with breast cancer and diffuse large B-cell lymphoma(DLBCL).Although we initially administered the R-CHOP regimen, the breast tumor increased in size and surgery had to be performed.After surgery, the R-CHOP regimen was re-initiated and DLBCL achieved clinical complete response.Case 2 involved a 74-year-old woman with breast cancer and gastric MALT lymphoma.After administration of rituximab and H. pylori eradication, a therapeutic effect was achieved in the lymphoma.A docetaxel and FEC regimen was continuously administered and surgery was performed...
September 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Choong-Kyun Noh, Min Wook Jung, Sung Jae Shin, Ju Young Ahn, Hyo Jung Cho, Min Jae Yang, Soon Sun Kim, Sun Gyo Lim, Dakeun Lee, Young Bae Kim, Jae Youn Cheong, Kee Myung Lee, Byung Moo Yoo, Kwang Jae Lee
BACKGROUND AND AIM: The histologic discrepancies between preoperative endoscopic forceps biopsy (EFB) and endoscopic submucosal dissection (ESD) specimens sometimes confuse the endoscope operator. This study aimed to analyze the limitation of the biopsy-based diagnosis before ESD and to evaluate which factors affect the discordant pathologic results between EFB and ESD. METHODS: A total of 1427 patients, who were diagnosed with gastric adenoma by EFB, were enrolled...
September 3, 2018: Digestive and Liver Disease
Chen-Shuan Chung, Cho-Lun Tsai, Yin-Yi Chu, Kuan-Chih Chen, Jung-Chun Lin, Bao-Chung Chen, Wei-Chih Sun, Hsu-Heng Yen, Chiung-Yu Chen, I-Chen Wu, Chao-Hung Kuo, Hisang-Yao Shih, Ming-Jong Bair, Jack P Wang, Wen-Hao Hu, Chang-Shyue Yang, Ming-Lun Han, Tsu-Yao Cheng, Chao-Ming Tseng, Ming-Chang Tsai, Ming-Luen Hu, Hsiu-Po Wang
Gastric neuroendocrine tumors (GNETs) are a heterogeneous group of neoplasm with varying biological characteristics. This study aimed to investigate the clinical features and outcomes of GNET patients after endoscopic diagnosis and treatment in a multicenter registry. Patients with GNETs confirmed histologically were recruited from 17 hospitals between January 2010 and April 2016 in Taiwan. Clinical, laboratory, radiological, endoscopic, pathological data, treatment strategies, follow-up periods, and survivals were collected retrospectively...
September 2018: Medicine (Baltimore)
Zhengyan Li, Yezhou Liu, Bin Bai, Deliang Yu, Bo Lian, Qingchuan Zhao
BACKGROUND: To compare the surgical and long-term survival outcomes of laparoscopic and open total gastrectomy (OTG) for locally advanced gastric cancer (AGC). METHODS: We retrospectively evaluated 308 and 900 patients in pathological locally AGC who underwent laparoscopic total gastrectomy (LTG) or OTG between June 2008 and December 2014. We compared surgical and long-term outcomes between the two groups using propensity score matching method. RESULTS: The LTG group showed a longer operation time (261...
September 18, 2018: World Journal of Surgery
Tomoko Kitaichi, Osamu Dohi, Yasuko Fujita, Atsushi Majima, Yusuke Horii, Yuriko Yasuda-Onozawa, Kentaro Suzuki, Akira Tomie, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Mitsuo Kishimoto, Nobuaki Yagi, Yuji Naito, Akio Yanagisawa, Yoshito Itoh
BACKGROUND/AIMS: Gastric-type differentiated adenocarcinoma (GDA) of the stomach is a rare variant of gastric cancer that is highly infiltrating and exhibits early metastasis. However, the endoscopic and pathological features of "early-stage" GDA remain unknown. The aim of this study is to characterize early-stage GDA. METHODS: We retrospectively enrolled 479 differentiated-type early gastric cancer cases who underwent endoscopic submucosal dissection (ESD)...
September 18, 2018: Digestion
Yaru Wang, Wen Song, Pengcheng Kan, Chao Huang, Zhuolin Ma, Qiaoli Wu, Xiuhua Yao, Biao Zhang
Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood. The present study aimed to investigate the association of EPN3 expression with the clinicopathological features of patients with glioma, as well as the effects of EPN3 on glioblastoma cells and the potential molecular mechanisms for its effects on glioblastoma cell behavior...
November 2018: Oncology Reports
Jianfeng Zhang, Weifeng Ding, Xiaoling Kuai, Yimin Ji, Zhenglong Zhu, Zhenbiao Mao, Zhiwei Wang
Long non‑coding RNAs (lncRNAs) perform distinct biological functions by regulating gene expression through various molecular mechanisms under normal physiological and pathological conditions. However, the function of the stomach cancer‑associated transcript‑3 (STCAT3) lncRNA, including its prognostic significance and role as a binding protein in gastric cancer (GC), remain unclear. In the present study, 56 potential binding proteins of STCAT3 were screened using through mass spectrometry and bioinformatics analysis...
November 2018: Oncology Reports
Danilo Mazzacane, Valerio Damiani, Michela Silvestri, Giorgio Ciprandi, Pierfranco Marino
AIM: To suspect laryngopharyngeal reflux (LPR) in patients with ocular surface disease (OSD). METHODS: The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index (OSDI) and the Reflux Symptom Index (RSI) to detect patients with suspected LPR and define a possible relationship between tests. RESULTS: Two hundred and ninety subjects (175 females, mean age: 60.41±15.68y) were consecutively visited at ophthalmologist offices...
2018: International Journal of Ophthalmology
M Mohamud, L Osborne, H G Jones, A Ahmed, J Beynon, D A Harris, M Evans, M Davies, U Khot, T V Chandrasekaran
Background: Blood platelet measurement is a widely available and inexpensive test that is performed routinely. Platelets are thought to act by inducing inflammation and play a role in clotting and antimicrobial defence. A postoperative rise in the platelet count (thrombocytosis) is often dismissed as an incidental finding, but there is growing evidence to suggest that it may act as an indicator to underlying pathology. It correlates with significant pyogenic infections as well as multiple malignancies...
2018: Gastroenterology Research and Practice
Mark A Rodgers, Cassaundra Ameel, Amy L Ellis-Connell, Alexis J Balgeman, Pauline Maiello, Gabrielle L Barry, Thomas C Friedrich, Edwin Klein, Shelby L O'Connor, Charles A Scanga
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), is the leading cause of death among HIV positive patients. The precise mechanisms by which HIV impairs host resistance to a subsequent M.tb infection are unknown. We modeled this co-infection in Mauritian cynomolgus macaques (MCM) using SIV as an HIV surrogate. We infected seven MCM with SIVmac239 intrarectally and six months later co-infected them via bronchoscope with ∼10 CFU M.tb Another eight MCM were infected with M.tb alone. TB progression was monitored by clinical parameters, by culturing bacilli in gastric and bronchoalveolar lavages, and by serial 18 F-FDG PET/CT imaging...
September 17, 2018: Infection and Immunity
Yuichiro Miki, Masakazu Yashiro, Tomohisa Okuno, Kenji Kuroda, Shingo Togano, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: It has been reported that CD63, an exosome marker, is expressed in solid cancer tissues. However, its significance in patients with gastric cancer has not been clarified. Exosomes derived from cancer cells and stromal cells might play an important role in the intracellular communications involved in the development of carcinoma. This study aimed to clarify the relationship between CD63 expression in cancer cells and stromal cells and clinical-pathologic factors. METHODS: A total of 595 gastric cancer patients were enrolled in this study...
2018: PloS One
Ho-Jae Lee, Young-Min Han, Jeong Min An, Eun A Kang, Yong Jin Park, Ji-Young Cha, Ki Baik Hahm
Although inflammation is defensive and healing process that maintains organ homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs abundant in Western diet, are precursors of pro-inflammatory mediators, whereas n-3 PUFAs possess anti-inflammatory properties. Therefore, interest in the cancer-preventive effect of n-3 PUFAs is increasing. Areas covered: We have observed significant reductions of gastrointestinal (GI) tumorigenesis in the Fat-1 transgenic mouse as evidenced that the decrease in Helicobacter pylori-infected gastric tumorigenesis, colon, biliary and pancreatic cancer was seen in Fat-1 mice producing n-3 PUFAs...
September 17, 2018: Expert Review of Anticancer Therapy
David K van der Poorten, Duncan McLeod, Golo Ahlenstiel, Scott Read, Avelyn Kwok, Cositha Santhakumar, Milan Bassan, Suzanne Culican, David Campbell, Sue W J Wong, Louise Evans, Bilel Jideh, Alisa Kane, Constance H Katelaris, Karuna Keat, Yanna Ko, Jessie A Lee, Sandhya Limaye, Ming Wei Lin, Ari Murad, Martina Rafferty, Dan Suan, Sanjay Swaminathan, Sean D Riminton, Catherine Toong, Lucinda J Berglund
Individuals with common variable immunodeficiency (CVID) have an increased risk of gastric cancer, and gastrointestinal lymphoma, yet screening for premalignant gastric lesions is rarely offered routinely to these patients. Proposed screening protocols are not widely accepted and are based on gastric cancer risk factors that are not applicable to all CVID patients. Fifty-two CVID patients were recruited for screening gastroscopy irrespective of symptoms or blood results and were compared to 40 controls presenting for gastroscopy for other clinical indications...
September 15, 2018: Journal of Clinical Immunology
Desmond Kwan Kit Chan, Fion Siu Yin Chan, Daniel King Hung Tong, Ian Yu Hong Wong, Claudia Lai Yin Wong, Tsz Ting Law, Simon Ying Kit Law
Background: Esophagectomy remains the mainstay treatment for esophageal cancer. Minimally invasive techniques have gained popularity in recent years. Whether minimally invasive methods result in equivalent or superior outcome to open esophagectomy or not is still controversial. The aim of the current study is to compare outcomes of minimally invasive and open esophagectomy from a single institution, using propensity score matching to lessen biases. Methods: From 1994-2016, 724 patients with squamous cell cancer of the esophagus who underwent esophagectomy were studied...
September 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Nao Yoshizawa, Hirokazu Yamaguchi, Michio Kaminishi
INTRODUCTION: Solitary Peutz-Jeghers-type polyps of the stomach are extremely rare. They are defined as unique polyps that are not associated with Peutz-Jeghers syndrome (PJS). PRESENTATION OF CASE: A 37-year-old woman presented at our hospital with anemia and epigastric discomfort. Esophagogastroduodenoscopy to determine the cause of anemia revealed a 5 × 6-cm pedunculated polypoid tumor at the greater curvature of the upper gastric body. Pathological examination of a biopsy specimen confirmed a Group 1 hyperplastic polyp...
September 10, 2018: International Journal of Surgery Case Reports
Ana Caren Cortés-Márquez, Sandra Mendoza-Elizalde, Francisco Arenas-Huertero, Jimena Trillo-Tinoco, Pedro Valencia-Mayoral, Alejandra Consuelo-Sánchez, Jonathan Zarate-Franco, Ada Ruth Dionicio-Avendaño, José de Jesús Herrera-Esquivel, Elio Germán Recinos-Carrera, Christian Colín-Valverde, Sandra Rivera-Gutiérrez, Alfonso Reyes-López, Juan Carlos Vigueras-Galindo, Norma Velázquez-Guadarrama
BACKGROUND: Helicobacter pylori is a major aetiologic agent associated with gastritis. H. pylori infections increase the expression of the Toll-like receptor (TLR), which in turn modulates the expression of microRNA (miRNA)-146a and miRNA-155. The objective of this study was to compare the expression of miRNA-146a and miRNA-155 in gastric lesions of paediatric and adult patients with different pathologies and in Mongolian gerbils (Meriones unguiculatus) infected with H. pylori 26,695...
September 15, 2018: BMC Infectious Diseases
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