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https://www.readbyqxmd.com/read/28431271/investigation-of-pathology-malpractice-claims-in-china-from-2002-2015
#1
Yuan Li, Dong Gao, Meng Tu, Ying-Zhen Luo, Zhen-Hua Deng
OBJECTIVE: To examine pathology-related medical claims in China and identify the most common errors to result in such claims. METHOD: A retrospective analysis was performed of 71 forensic evaluation reports carried out in two Chinese institutes of forensic medicine between 2002 and 2015 due to suspicion of medical malpractice. The judicial outcomes of each case were also reviewed when available. RESULTS: Of 71 cases, 54 cases had judicial outcomes...
April 15, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28430970/helicobacter-pylori-outer-membrane-vesicles-inhibit-human-t-cell-responses-via-induction-of-monocyte-cox-2-expression
#2
Barry D Hock, Judith L McKenzie, Jacqueline I Keenan
The modulation of T cell responses by Helicobacter pylori is thought to potentiate both H. pylori persistence and development of gastric pathologies including cancer. Release of outer membrane vesicles (OMV) by H. pylori provides a potential vehicle for modulation of the immune system. Although OMV are thought to have T cell suppressive activity this has not yet been demonstrated. Their suppressive activity was investigated in this study using the responses of peripheral blood mononuclear cells (PBMC) to T cell stimuli as a readout...
April 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28430541/a-comprehensive-approach-to-hepatic-vascular-disease
#3
Khaled M Elsayes, Akram M Shaaban, Sarah M Rothan, Sanaz Javadi, Beatrice L Madrazo, Rosa P Castillo, Victor J Casillas, Christine O Menias
The liver has a complex vascular supply, which involves the inflow of oxygenated blood through the hepatic artery (systemic circulation) and deoxygenated blood through the portal vein (portal circulation), as well as the outflow of deoxygenated blood through the hepatic veins to the inferior vena cava. A spectrum of vascular variants can involve the liver. Some of these variants may result in areas of enhancement that can mimic more serious pathologic conditions. In this article, the authors discuss a spectrum of variants and pathologic conditions that may involve the liver vasculature...
April 21, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28429624/impact-of-high-dose-oleuropein-on-cisplatin-induced-oxidative-stress-genotoxicity-and-pathological-changes-in-rat-stomach-and-lung
#4
Fatime Geyikoglu, Hatice Isikgoz, Hakan Onalan, Suat Colak, Salim Cerig, Murat Bakir, Mirkhalil Hosseinigouzdagani, Kubra Koc, Huseyin Serkan Erol, Yavuz Selim Saglam, Serkan Yildirim
The current systemic treatments of the various solid tumors involve Cisplatin (CIS)-based chemotherapy. Due to its cytotoxicity, this approach is limited. Moreover, the safety of CIS is only discussed especially in breast and stomach cancers. Therefore, we, for the first time, explored the restorative efficacy of oleuropein (OLE), in stomach and lung injuries induced by CIS. Sprague-Dawley rats were divided into eight groups: control CIS, OLE and CIS + OLE. Single dose of (7 mg/kg) CIS was administered intraperitoneally to CIS and CIS + OLE groups...
April 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28429199/gastric-bypass-and-influence-on-improvement-of-nafld
#5
REVIEW
Vamsi Alli, Ann M Rogers
PURPOSE OF REVIEW: Obesity is recognized as a chronic and recurring disease, often accompanied by other weight-related comorbid conditions such as obstructive sleep apnea, hypertension, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). This chapter will seek to focus on the effect of weight loss surgery (WLS), in particular Roux-en-Y gastric bypass (RYGB), on NAFLD. RECENT FINDINGS: Among several modalities available to treat NAFLD, the one most likely to achieve rapid, significant, and sustained improvement of liver disease is WLS...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28428514/-a-case-report-of-disappearance-of-gastric-metastasis-of-breast-cancer-treated-with-combination-therapy-consisting-of-paclitaxel-and-cisplatin
#6
Tooru Nakajima, Koichi Taniwaka, Hideki Goto, Shunji Kawamura
A 63-year-old postmenopausal woman was treated with combination therapy consisting of paclitaxel(PTX)and cisplatin (CDDP)for gastric metastasis of breast cancer; she achieved a complete response as revealed by pathological examination. Combination therapy with PTX and CDDP seems to be an optional treatment for gastric metastasis of breast cancer.
April 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28424782/clinical-significance-of-preoperative-albumin-and-globulin-ratio-in-patients-with-gastric-cancer-undergoing-treatment
#7
Min-Jie Mao, Xiao-Li Wei, Hui Sheng, Xue-Ping Wang, Xiao-Hui Li, Yi-Jun Liu, Shan Xing, Qi Huang, Shu-Qin Dai, Wan-Li Liu
Background. The pretreatment albumin and globulin ratio (AGR) was an inflammation-associated factor which was related to the overall survival in various malignancies. The aim of this study was to evaluate the prognostic value of AGR in patients with gastric cancer. Method. This retrospective study included 862 cases pathologically diagnosed with gastric cancer. All patients were randomly divided into the testing group (431 cases) and validation group (431 cases). The relationships of AGR with clinicopathologic characteristics and prognosis were analyzed by Kaplan-Meier and Cox regression methods...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28423564/hypermethylation-of-the-chrdl1-promoter-induces-proliferation-and-metastasis-by-activating-akt-and-erk-in-gastric-cancer
#8
Yao-Fei Pei, Ya-Jing Zhang, Yao Lei, Ding-Wei Wu, Tong-Hui Ma, Xi-Qiang Liu
CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis. Herein, we report that CHRDL1 expression was significantly down-regulated in gastric cancer tissues and associated with poor survival. Clinic-pathological parameters demonstrated a close relationship between low CHRDL1 expression and metastasis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423364/increased-expression-of-deleted-in-malignant-brain-tumors-dmbt1-gene-in-precancerous-gastric-lesions-findings-from-human-and-animal-studies
#9
Jone Garay, M Blanca Piazuelo, Lizbeth Lopez-Carrillo, Yelda A Leal, Sumana Majumdar, Li Li, Nataly Cruz-Rodriguez, Silvia J Serrano-Gomez, Carlos S Busso, Barbara G Schneider, Alberto G Delgado, Luis E Bravo, Angela M Crist, Stryder M Meadows, M Constanza Camargo, Keith T Wilson, Pelayo Correa, Jovanny Zabaleta
Helicobacter pylori infection triggers a cascade of inflammatory stages that may lead to the appearance of non-atrophic gastritis, multifocal atrophic, intestinal metaplasia, dysplasia, and cancer. Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in host defense by binding to pathogens. Initial studies showed its deletion and loss of expression in a variety of tumors but the role of this gene in tumor development is not completely understood...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418926/urinary-kallikrein-10-predicts-the-incurability-of-gastric-cancer
#10
Takaya Shimura, Masahide Ebi, Tomonori Yamada, Tamaki Yamada, Takahito Katano, Yu Nojiri, Hiroyasu Iwasaki, Satoshi Nomura, Noriyuki Hayashi, Yoshinori Mori, Hiromi Kataoka, Marsha A Moses, Takashi Joh
The current imaging modalities are not sufficient to identify inoperable tumor factors, including distant metastasis and local invasion. Hence, we conducted this study using urine samples to discover non-invasive biomarkers for the incurability of gastric cancer (GC). Urine samples from 111 GC patients were analyzed in this study. The GC cohort was categorized and analyzed according to disease stage and operability. In the discovery phase, protease protein array analysis identified 3 potential candidate proteins that were elevated in the urine of advanced GC patients compared to early GC patients...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417260/five-year-survival-analysis-of-surgically-resected-gastric-cancer-cases-in-japan-a-retrospective-analysis-of-more-than-100-000-patients-from-the-nationwide-registry-of-the-japanese-gastric-cancer-association-2001-2007
#11
Hitoshi Katai, Takashi Ishikawa, Kohei Akazawa, Yoh Isobe, Isao Miyashiro, Ichiro Oda, Shunichi Tsujitani, Hiroyuki Ono, Satoshi Tanabe, Takeo Fukagawa, Souya Nunobe, Yoshihiro Kakeji, Atsushi Nashimoto
BACKGROUND: The aim of this retrospective study was to investigate the tumor characteristics, surgical details, and survival distribution of surgically resected cases of gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association. METHODS: Data from 118,367 patients with primary gastric carcinoma who underwent resection between 2001 and 2007 were included in the survival analyses. The 5-year survival rates were calculated for various subsets of prognostic factors...
April 17, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28413653/a-novel-option-for-preoperative-endoscopic-marking-with-india-ink-in-totally-laparoscopic-distal-gastrectomy-for-gastric-cancer-a-useful-technique-considering-the-morphological-characteristics-of-the-stomach
#12
Takaya Tokuhara, Eiji Nakata, Toshiyuki Tenjo, Isao Kawai, Syunpei Satoi, Keisuke Inoue, Mariko Araki, Hirofumi Ueda, Chihiro Higashi
In totally laparoscopic distal gastrectomy (TLDG) for gastric cancer, accurately determining the proximal resection line may be difficult. This is because identifying the lesion intracorporeally is impossible, due to the lack of tactile sense, and, in addition, unlike the intestine, the most proximal site of the lesion is often different from the main site due to the distorted shape of the stomach. The aim of this study was to introduce a novel method of preoperative endoscopic marking with India ink, taking into consideration the morphological characteristics of the stomach...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413454/helicobacter-pylori-vaca-s1m1-genotype-but-not-caga-or-baba2-increase-the-risk-of-ulcer-and-gastric-cancer-in-patients-from-southern-mexico
#13
Adolfo Román-Román, Dinorah Nashely Martínez-Carrillo, Josefina Atrisco-Morales, Julio César Azúcar-Heziquio, Abner Saúl Cuevas-Caballero, Carlos Alberto Castañón-Sánchez, Roxana Reyes-Ríos, Reyes Betancourt-Linares, Salomón Reyes-Navarrete, Iván Cruz-Del Carmen, Margarita Camorlinga-Ponce, Enoc Mariano Cortés-Malagón, Gloria Fernández-Tilapa
BACKGROUND: The vacA, cagA and babA2 genotypes of Helicobacter pylori are associated with gastric pathology. The objectives were to determine the frequency of infection and distribution of the vacA, cagA and babA2 genotypes of H. pylori in patients with gastric ulcer, chronic gastritis and gastric cancer, and to evaluate the association of virulent genotypes with diagnosis. METHODS: We studied 921 patients with symptoms of dyspepsia or with presumptive diagnosis of gastric cancer...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28408983/recent-advances-in-understanding-epstein-barr-virus
#14
REVIEW
Brent A Stanfield, Micah A Luftig
Epstein-Barr virus (EBV) is a common human herpes virus known to infect the majority of the world population. Infection with EBV is often asymptomatic but can manifest in a range of pathologies from infectious mononucleosis to severe cancers of epithelial and lymphocytic origin. Indeed, in the past decade, EBV has been linked to nearly 10% of all gastric cancers. Furthermore, recent advances in high-throughput next-generation sequencing and the development of humanized mice, which effectively model EBV pathogenesis, have led to a wealth of knowledge pertaining to strain variation and host-pathogen interaction...
2017: F1000Research
https://www.readbyqxmd.com/read/28407837/-effects-of-embryonic-lead-exposure-on-food-intake-and-bowel-movement-in-offspring-rats-and-possible-mechanisms
#15
Jian-Ping Zhou, Fan Wang, Xiao-Qing Yi, Xue-Ying Wang, Yong-Sheng Jiang, Yan Geng, Jing-Jing Wang
OBJECTIVE: To study the effects of embryonic lead exposure on food intake and bowel movement in offspring rats and possible mechanisms. METHODS: Sprague-Dawley rats were given 0.1% (low-dose lead exposure group) or 0.2% (high-dose lead exposure group) lead acetate freely during pregnancy to establish an animal model of embryonic lead exposure. A blank control group was also established. The male offspring rats were enrolled in the study, and 10 male offspring rats from each group were selected to observe the changes in food intake, bowel movement, gastric emptying, intestine propulsion, and pathological inflammatory response in the gastric mucosa...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28403883/dc-signr-by-influencing-the-lncrna-hnrnpkp2-upregulates-the-expression-of-cxcr4-in-gastric-cancer-liver-metastasis
#16
Yu Zhang, Qianshi Zhang, Mengyang Zhang, Menglang Yuan, Zhaohui Wang, Jingbo Zhang, Xu Zhou, Yinan Zhang, Fang Lin, Heya Na, Shuangyi Ren, Yunfei Zuo
BACKGROUND: Profiling evidences of selectin demonstrate that they play an crucial role in cancer progression and metastasis. However, DC-SIGNR as a family member of selectin participates in gastric cancer liver metastasis remains unknown. METHODS: The serum level of DC-SIGNR was evaluated in gastric cancer patients by ELISA. Manipulation DC-SIGNR expression in BGC823 and SGC7901 cell lines was mediated by lentivirus. Investigation the biological effects of DC-SIGNR were verified by MTT, wounding and transwell in vitro and experiments on animals to confirm gastric cancer liver metastasis by IVIS...
April 13, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28403590/efficacy-of-pollen-extract-in-association-with-group-b-vitamins-for-pain-relief-in-chronic-prostatitis-chronic-pelvic-pain-syndrome-a-survey-of-urologists-knowledge-about-its-clinical-application
#17
Giacomo Maria Pirola, Stefano Puliatti, Tommaso Bocchialini, Eugenio Martorana, Salvatore Micali, Giampaolo Bianchi
INTRODUCTION AND AIM OF THE STUDY: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPSS) is a pathology of high prevalence in Italian male population, difficult to diagnose and to treat and with poor response to conventional therapy. Aim of this study was to review the evidence of the literature about the therapeutic effects of a plant product containing flower pollen extracts and group B vitamins on symptoms resolution and amelioration of CP/CPPS patients' quality of life and to investigate the knowledge among practicing urologists about the clinical application of this product...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28403101/prognostic-value-of-histological-subtype-in-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-a-retrospective-analysis-of-outcome-from-one-single-center
#18
Yefei Rong, Dansong Wang, Chen Xu, Yuan Ji, Dayong Jin, Wenchuan Wu, Xuefeng Xu, Tiantao Kuang, Wenhui Lou
We sought to retrospectively analyze the outcomes of patients with intraductal papillary mucinous neoplasm (IPMN) at our pancreatic surgery center, and to evaluate the prognostic value of histological subtype.The clinical data of 121 IPMNs treated in our center between 2005 and 2014 were retrospectively analyzed. Pathological slides were thoroughly reviewed by 2 specialized pathologists.Of the 121 patients, 48, 57, and 16 had main-duct, branch-duct, and mixed type IPMNs, respectively. Forty-one patients had invasive IPMNs...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28401064/helicobacter-pylori-induced-phosphatidylinositol-3-oh-kinase-mtor-activation-increases-hypoxia-inducible-factor-1%C3%AE-to-promote-loss-of-cyclin-d1-and-g0-g1-cell-cycle-arrest-in-human-gastric-cells
#19
Jimena Canales, Manuel Valenzuela, Jimena Bravo, Paulina Cerda-Opazo, Carla Jorquera, Héctor Toledo, Denisse Bravo, Andrew F G Quest
Helicobacter pylori (H. pylori) is a human gastric pathogen that has been linked to the development of several gastric pathologies, such as gastritis, peptic ulcer, and gastric cancer. In the gastric epithelium, the bacterium modifies many signaling pathways, resulting in contradictory responses that favor both proliferation and apoptosis. Consistent with such observations, H. pylori activates routes associated with cell cycle progression and cell cycle arrest. H. pylori infection also induces the hypoxia-induced factor HIF-1α, a transcription factor known to promote expression of genes that permit metabolic adaptation to the hypoxic environment in tumors and angiogenesis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28400994/pathological-diagnosis-of-gastric-cancers-with-a-novel-computerized-analysis-system
#20
Kosuke Oikawa, Akira Saito, Tomoharu Kiyuna, Hans Peter Graf, Eric Cosatto, Masahiko Kuroda
BACKGROUND: Recent studies of molecular biology have provided great advances for diagnostic molecular pathology. Automated diagnostic systems with computerized scanning for sampled cells in fluids or smears are now widely utilized. Automated analysis of tissue sections is, however, very difficult because they exhibit a complex mixture of overlapping malignant tumor cells, benign host-derived cells, and extracellular materials. Thus, traditional histological diagnosis is still the most powerful method for diagnosis of diseases...
2017: Journal of Pathology Informatics
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