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https://www.readbyqxmd.com/read/30024703/gastroesophageal-variceal-bleeding-an-overview-of-current-treatment-options
#1
REVIEW
Marinko Marušić, Antonio Klemenčić, Rosana Troskot Perić, Goran Hauser
Gastroesophageal variceal hemorrhage is the most important clinical event that results from portal hypertension. It is a lifethreatening condition that demands rapid and efficient treatment. The first step in bleeding control is hemodynamic stabilization and pharmacological treatment, which includes administration of vasoactive drugs and short-term antibiotic prophylaxis. After initial hemodynamic stabilization, endoscopic therapy should be performed. The first choice of endoscopic treatment for esophageal bleeding is endoscopic variceal ligation (EVL), or endoscopic injection sclerotherapy (EIS) if EVL cannot be performed...
April 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/30024074/gastroprotective-and-anti-ulcer-effects-of-oxymatrine-against-several-gastric-ulcer-models-in-rats-possible-roles-of-antioxidant-antiinflammatory-and-prosurvival-mechanisms
#2
Yan Fu, Huan-Qing Wu, Huai-Liang Cui, Yue-Yun Li, Chang-Zheng Li
Oxymatrine (OXY) has antioxidative and antiinflammatory activities. In the present work, we investigate the effects of OXY on gastric ulcer models and elucidate the underlying mechanisms of action. Ethanol, indometacin, and restraint water immersion stress-induced ulcerated models were used. The ulcer area was measured, and samples of gastric tissue were taken for pathological, histochemical, and biochemical analyses. OXY effectively reduced the area of gastric ulcers and improved the pathological changes of ulcerated tissue...
July 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30023977/survival-outcomes-after-d1-and-d2-lymphadenectomy-with-r0-resection-in-stage-ii-iii-gastric-cancer-longitudinal-follow-up-in-a-single-center
#3
Adam Uslu, Baha Zengel, Enver İlhan, Ahmet Aykas, Cenk Şimşek, Orhan Üreyen, Ali Duran, Gökalp Okut
Objective: D2 lymphadenectomy (D2-LND) with curative resection (R0) is the cornerstone of gastric cancer treatment. In this study, we compared survival outcomes of D2-LDN with D1-LDN in patients who had undergone curative resection for Stages II and III primary gastric adenocarcinoma. Material and Methods: Between April 1996 and March 2014, 153 consecutive patients with adenocarcinoma of the stomach underwent total gastrectomy with D1-LND or D2-LND. Among those, 118 patients (38 D1 vs...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/30022839/sirt4-acts-as-a-tumor-suppressor-in-gastric-cancer-by-inhibiting-cell-proliferation-migration-and-invasion
#4
Hongjie Sun, Dongli Huang, Guozheng Liu, Fengguo Jian, Jianfang Zhu, Lixia Zhang
Background: Previous study has proven that SIRT4 is downregulated in gastric cancer (GC), but the role of SIRT4 has not been clearly understood. The aim of our work was to explore in detail the function and mechanism of SIRT4 in GC. Methods: A total of 86 pairs of GC tumor tissues and adjacent normal tissues were collected, and quantitative real-time polymerase chain reaction and Western blotting analyses were used to determine the expression of SIRT4. Results: Our study revealed that the expression of SIRT4 was downregulated in GC tissues and cells...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30020407/optimal-intraoperative-assessment-of-gastric-margins
#5
Romulo Celli, Andrea L Barbieri, Monica Colunga, John Sinard, Joanna A Gibson
Objectives: Intraoperative pathology consultation (IOC) to assess margins is frequently requested during surgery of the stomach and gastroesophageal junction. Methods: We studied 110 consecutive patients undergoing gastrectomy with IOC margin assessment. Results: Gastric margins at IOC utilized the most blocks but were least often positive. In 64% of patients, the entire gastric margin was examined using average six blocks; representative sections were examined in 25% of patients using two blocks...
July 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/30019280/no-difference-in-ghrelin-producing-cell-expression-in-obese-versus-non-obese-stomach-a-prospective-histopathological-case-control-study
#6
Mario Musella, Francesco Di Capua, Maria D'Armiento, Nunzio Velotti, Alessio Bocchetti, Katia Di Lauro, Giuseppe Galloro, Severo Campione, Giuseppe Petrella, Francesco Paolo D'Armiento
BACKGROUND: To understand the role of ghrelin in the mechanism of action of laparoscopic sleeve gastrectomy (LSG), a prospective cohort case-control study to assess the expression of ghrelin-producing cells (GPC) in two groups of patients was designed. METHODS: Specimens of resected stomach from 26 obese patients who underwent LSG (group A), were compared by immunohistochemistry to control stomach samples from 26 non-obese patients (group B) resected for other pathologies or during autopsy; (GIST: 6 cases, inflammatory diseases: 4 cases, post-mortem autopsy cases with stomachs from healthy persons victims of traumatic accidents: 16 cases)...
July 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30018486/gastric-adenocarcinoma-of-fundic-gland-type-with-signet-ring-cell-carcinoma-component-a-case-report-and-review-of-the-literature
#7
Keita Kai, Masaaki Satake, Osamu Tokunaga
A depressed lesion was found at a gastric angle of 76-year-old Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection (ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae...
July 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30014670/-time-effect-relationship-and-molecular-mechanism-of-electroacupuncture-for-repair-of-gastric-mucosal-lesion
#8
Yuan Zhang, Caichun Liu, Linyu Lian, Jiacheng Shen, Qida He, Jiaolong Chen, Fuqiang Ma, Zongbao Yang
OBJECTIVE: To dynamically observe the effects of electroacupuncture (EA) on repair of gastric mucosal lesion in rats with gastric ulcer, and to explore the time-effect relationship and molecular mechanism of EA for gastric ulcer. METHODS: A total of 72 SD rats were randomly assigned to a normal group, a model group, a acupoint group and a sham acupoint group, and each group were further divided into a 1-day subgroup, a 4-day subgroup and a 7-day subgroup, 6 rats in each subgroup...
July 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/30014492/pathological-features-of-total-gastrectomy-specimens-from-asymptomatic-hereditary-diffuse-gastric-cancer-patients-and-implications-for-clinical-management
#9
REVIEW
João P Rocha, Irene Gullo, Xiaogang Wen, Vítor Devezas, Manuela Baptista, Carla Oliveira, Fátima Carneiro
AIMS: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant syndrome characterized by multigenerational diffuse GC and is mainly caused by germline alterations in the CDH1 gene. Currently, endoscopy has limited diagnostic accuracy and total gastrectomy (TG) is the treatment of choice for asymptomatic CDH1 carriers. In this study, we aimed at a better understanding of HDGC syndrome, by exploring the histopathological findings of TG specimens from asymptomatic HDGC patients...
July 17, 2018: Histopathology
https://www.readbyqxmd.com/read/30014330/clinicopathological-characteristics-of-patients-with-pain-after-endoscopic-submucosal-dissection-for-gastric-epithelial-neoplasm
#10
Jung-Wook Kim, Jae-Young Jang, Yoo Min Park, Jae-Jun Shim, Young Woon Chang
BACKGROUND: Endoscopic submucosal dissection (ESD) is widely used for large superficial gastrointestinal tumors. Epigastric pain is a frequent complication of ESD. However, little is known about its incidence and associated factors. This study evaluated pain incidence and characteristics of patients with pain after gastric ESD. METHODS: We retrospectively analyzed a prospectively collected registry of clinical, endoscopic, and pathologic results of patients who underwent ESD for gastric adenoma or cancer from January 2010 to December 2015...
July 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30012565/evolutionary-expression-of-her2-conferred-by-chromosome-aneuploidy-on-circulating-gastric-cancer-cells-contributes-to-developing-targeted-and-chemotherapeutic-resistance
#11
Yilin Li, Xiaotian Zhang, Dan Liu, Ji-Fang Gong, Daisy Dandan Wang, Shan Li, Zhi Peng, Yan Yan Li, Xiaojuan Wang, Peter P Lin, Min Li, Lin Shen
PURPOSE: Previous human epidermal growth factor receptor-2 (HER2)-derived resistance studies were based on ex vivo models, which could not mirror evolutionary expression of HER2 during therapy. To investigate dynamic expression of HER2 and its contribution to developing therapeutic resistance conferred by chromosome aneuploidy, both HER2 phenotype and chromosome 8 aneuploidy on CTCs were co-examined in advanced gastric cancer (AGC) patients. EXPERIMENTAL DESIGN: Total of 115 AGC patients, including 56 of histo-pathological HER2+ (hHER2+ ) subjects who received first-line HER2-targeted therapy plus chemotherapy, and 59 of hHER2- patients who received chemotherapy alone, were prospectively enrolled...
July 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30010108/correlations-of-tnm-staging-and-lymph-node-metastasis-of-gastric-cancer-with-mri-features-and-vegf-expression
#12
Lan Pang, Jing Wang, Yong Fan, Rui Xu, Yuping Bai, Liangcai Bai
OBJECTIVE: To investigate the correlations of expression of vascular endothelial growth factor (VEGF) in gastric cancer tissues of patients and magnetic resonance imaging (MRI) features with clinical tumor-node-metastasis (TNM) staging and lymph node metastasis, and to analyze the diagnostic value of MRI features for preoperative TNM staging and lymph node metastasis of patients with gastric cancer, and the roles of VEGF in tumor development and metastasis. METHODS: A total of 120 gastric cancer patients treated in our hospital from May 2015 to July 2017 were selected as objects of study...
June 27, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30006753/differential-expression-of-e-cadherin-and-p-cadherin-in-pt3-prostate-cancer-correlation-with-clinical-and-pathological-features
#13
Catarina Ferreira, João Lobo, Luís Antunes, Paula Lopes, Carmen Jerónimo, Rui Henrique
Cadherins seem to play and important role in prostate cancer (PCa) progression. E-cadherin loss of expression has been associated with poor prognosis; P-cadherin's role is still elusive. Although pT3 PCa is often considered "high-risk cancer," it does not exhibit an uniformly poor prognosis. Herein, we assessed the prognostic value and survival impact of E-cadherin and P-cadherin immunoexpression in pT3 PCa. Radical prostatectomy (RP) specimens from 102 pT3 PCa patients treated between 1991 and 2014 in a single institution were designated for E-cadherin and P-cadherin immunoexpression analysis...
July 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30006603/hippo-pathway-affects-survival-of-cancer-patients-extensive-analysis-of-tcga-data-and-review-of-literature
#14
Anello Marcello Poma, Liborio Torregrossa, Rossella Bruno, Fulvio Basolo, Gabriella Fontanini
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30003735/correlation-of-cox-2-and-mmp-13-expressions-with-gastric-cancer-and-their-effects-on-prognosis
#15
Jianli Ren, Jian Liu, Xin Sui
PURPOSE: To study the expressions of cyclooxygenase-2 (COX-2) and matrix metalloproteinase-13 (MMP-13) genes in gastric cancer, and to investigate the correlation between them and gastric cancer and their effects onprognosis. METHODS: 80 cases of tumor tissues and 40 cases of normal tumor-adjacent tissues were collected from patients with gastric cancer admitted to the Surgical Department of our hospital. The mRNA expression levels of COX-2 and MMP- 13 in tumor tissues and normal tumor-adjacent tissues were detected via real-time fluorescence reverse transcription polymerase chain reaction (RT-PCR)...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/30002760/intrahepatic-cholangiocarcinoma-in-an-obese-patient-qualified-for-laparoscopic-bariatric-surgery-a-case-study
#16
Maciej Walędziak, Anna Różańska-Walędziak, Piotr K Kowalewski, Krzysztof Paśnik
Intrahepatic cholangiocarcinoma is a rare type of biliary tract malignancy, seldom found resectable at diagnosis, the 5-year survival rate depending on the possibility of complete surgical excision. In most cases it is only accidentally found in the early stage. The report presents a case of a 58-year-old obese male patient qualified for laparoscopic Roux-en-Y gastric bypass. During general inspection of the abdominal cavity, a tumor of 10 mm in diameter was found in the second hepatic segment and resected...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/30002748/indications-and-benefits-of-intraoperative-esophagogastroduodenoscopy
#17
Martin Stašek, René Aujeský, Radek Vrba, Martin Loveček, Josef Chudáček, Petr Janda, Michal Gregořík, Katherine Vomáčková, Čestmír Neoral, Dušan Klos
Introduction: Intraoperative esophagogastroduodenoscopy (IOG) is a diagnostic and therapeutic method for a variety of special conditions in upper gastrointestinal (UGI) pathology. The indication remains individual due to insufficient evidence and limited training of surgeons in digestive endoscopy. Aim: To evaluate the indications, benefits and risks of IOG. Material and methods: A single-center retrospective study of 110 consecutive IOGs in 104 patients was performed...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29996310/-the-precise-pathologic-diagnosis-of-gastric-cancer-some-significant-issues-in-clinical-practice
#18
X S Fan, L Li, Q Huang
No abstract text is available yet for this article.
July 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29996281/-the-influence-of-cyp2a6-polymorphism-on-adjuvant-s-1-chemotherapy-outcomes-in-patients-with-curatively-resected-gastric-cancer
#19
F K Hu, J Shen, S W Gao
Objective: Oral fiuoropyrimidine S-1 contains tegafur, gimeracil, oteracil. Tegafur is the major active prodrug, which is metabolized to 5-Fu by cytochrome P4502A6 (CYP2A6). This research investigated the association between CYP2A6 polymorphisms and treatment outcomes of adjuvant S-1 in gastric cancer patients. Methods: A total of 200 patients diagnosed pathological stage Ⅱ-Ⅲ gastric cancer were included in this study, who were received adjuvant S-1 chemotherapy regimens after curative surgery (40 mg/m(2,) bid, d1-28, rest 2 weeks, every 6 weeks one cycle)...
June 26, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29996188/-correlation-between-severity-of-gastroesophageal-reflux-cough-and-degree-of-gastroesophageal-reflux-disease
#20
S P Tang, Y L Liu, H Gao, L Dong, D R Lin, S Chen, D Y Zhang, L L Zhang, J Pan
Objective: To explore the correlation between the severity of gastroesophageal reflux cough and degree of gastroesophageal reflux. Methods: A cross-sectional investigation was carried out. Data of 174 cases of chronic cough were collected in Children's Hospital of Fuzhou from March 2009 to December 2016. The esophageal 24 hours pH value dynamic monitoring was used to detect gastric acid reflux index. Cases with abnomal results were divided into mild, moderate and severe groups according to severity of reflux and that of day and night cough symptoms, respectively...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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