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https://www.readbyqxmd.com/read/29156615/clinical-significance-of-measuring-global-hydroxymethylation-of-white-blood-cell-dna-in-prostate-cancer-comparison-to-psa-in-a-pilot-exploratory-study
#1
Alin Grelus, Dragos V Nica, Imola Miklos, Valerica Belengeanu, Ioan Ioiart, Cristina Popescu
This is the first study investigating the clinical relevance of 5-hydroxymethylcytosine (5hmC) in genomic DNA from white blood cells (WBC) in the context of prostate cancer (PCa) and other prostate pathologies. Using an enzyme-linked immunosorbent assay, we identified significantly different distributions of patients with low and elevated 5hmC content in WBC DNA across controls and patients with prostate cancer (PCa), atypical small acinar proliferation (ASAP), and benign prostatic hyperplasia (BPH). The measured values were within the normal range for most PCa patients, while the latter category was predominant for ASAP...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29155240/matrix-metalloproteinases-a-challenging-paradigm-of-cancer-management
#2
REVIEW
Ali Alaseem, Khalid Alhazzani, Priya Dondapati, Saad Alobid, Anupam Bishayee, Appu Rathinavelu
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has made them an attractive therapeutic target. Early generations of broad-spectrum MMP inhibitors exhibited potent inhibitory activities, which subsequently led to clinical trials. Unexpectedly, these trials failed to meet the desired goals, mainly due to the lack of efficacy, poor oral bioavailability, and toxicity...
November 16, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29155210/transition-from-androgenic-to-neurosteroidal-action-of-5%C3%AE-androstane-3%C3%AE-17%C3%AE-diol-through-the-type-a-%C3%AE-aminobutyric-acid-receptor-in-prostate-cancer-progression
#3
Ding Xia, Doan V Lai, Weijuan Wu, Zachary D Webb, Qing Yang, Lichao Zhao, Zhongxin Yu, Jessica E Thorpe, Bryan C Disch, Michael A Ihnat, Muralidharan Jayaraman, Danny N Dhanasekaran, Kelly L Stratton, Michael S Cookson, Kar-Ming Fung, Hsueh-Kung Lin
Androgen ablation is the standard of care prescribed to patients with advanced or metastatic prostate cancer (PCa) to slow down disease progression. Unfortunately, a majority of PCa patients under androgen ablation progress to castration-resistant prostate cancer (CRPC). Several mechanisms including alternative intra-prostatic androgen production and androgen-independent androgen receptor (AR) activation have been proposed for CRPC progression. Aldo-keto reductase family 1 member C3 (AKR1C3), a multi-functional steroid metabolizing enzyme, is specifically expressed in the cytoplasm of PCa cells; and positive immunoreactivity of the type A γ-aminobutyric acid receptor (GABAAR), an ionotropic receptor and ligand-gated ion channel, is detected on the membrane of PCa cells...
November 15, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29154904/risk-of-upgrading-from-prostate-biopsy-to-radical-prostatectomy-pathology-does-saturation-biopsy-of-index-lesion-during-mpmri-trus-fusion-biopsy-help
#4
Brian P Calio, Abhinav Sidana, Dordaneh Sugano, Sonia Gaur, Mahir Maruf, Amit L Jain, Maria J Merino, Peter L Choyke, Bradford J Wood, Peter A Pinto, Baris Turkbey
PURPOSE: To determine if 'saturation' of the index-lesion during MRI-TRUS fusion-guided (fusion) biopsy decreases rate of pathological upgrade from biopsy to radical-prostatectomy (RP). MATERIALS/METHODS: A prospectively maintained single institution database was analyzed for patients who underwent both fusion and systematic biopsy followed by RP (2010-16). Index-lesion was defined as lesion with largest diameter on T2W-MRI. Patients with saturation of the index-lesion (SIL) had transrectal fusion biopsy targets obtained at 6mm intervals along the long axis of index-lesion; patients with nonsaturation of the index-lesion (NSIL) had only one target obtained from the lesion...
November 15, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29153942/metabolic-syndrome-and-low-high-density-lipoprotein-cholesterol-are-associated-with-adverse-pathological-features-in-patients-with-prostate-cancer-treated-by-radical-prostatectomy
#5
Souhil Lebdai, Romain Mathieu, Julie Leger, Olivier Haillot, Sébastien Vincendeau, Nathalie Rioux-Leclercq, Georges Fournier, Marie-Aimée Perrouin-Verbe, Laurent Doucet, Abdel Rahmene Azzouzi, Jérome Rigaud, Karine Renaudin, Thomas Charles, Franck Bruyere, Gaelle Fromont
BACKGROUND: Previous studies have suggested a link between metabolic syndrome (MetS) and prostate cancer (PCa). In the present study, we aimed to assess the association between MetS and markers of PCa aggressiveness on radical prostatectomy (RP). METHODS: All patients consecutively treated for PCa by RP in 6 academic institutions between August 2013 and July 2016 were included. MetS was defined as at least 3 of 5 components (obesity, elevated blood pressure, diabetes, low high-density lipoprotein (HDL)-cholesterol, and hypertriglyceridemia)...
November 16, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29152231/does-penile-rehabilitation-have-a-role-in-the-treatment-of-erectile-dysfunction-following-radical-prostatectomy
#6
REVIEW
Gideon Blecher, Khaled Almekaty, Odunayo Kalejaiye, Suks Minhas
In men undergoing radical treatment for prostate cancer, erectile function is one of the most important health-related quality-of-life outcomes influencing patient choice in treatment. Penile rehabilitation has emerged as a therapeutic measure to prevent erectile dysfunction and expedite return of erectile function after radical prostatectomy. Penile rehabilitation involves a program designed to increase the likelihood of return to baseline-level erectile function, as opposed to treatment, which implies the therapeutic treatment of symptoms, a key component of post-radical prostatectomy management...
2017: F1000Research
https://www.readbyqxmd.com/read/29151366/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-76-85-edited-by-chinese-journal-of-cancer
#7
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77. How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pancreatic cancer and hepatocellular carcinoma? Question 79...
November 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29148719/effect-of-antigen-retrieval-methods-on-non-specific-binding-of-anti-body-metal-nanoparticle-conjugates-on-ffpe-tissue
#8
Yuying Zhang, Xinping Wang, Sven Perner, Ágnes Bánkfalvi, Sebastian Schlücker
Immunohistochemical analysis of FFPE tissues provides important diagnostic and prognostic information in pathology. Metal nanoparticles (NPs) and in particular surface-enhanced Raman scattering (SERS) nanotags as a new class of labelling reagents are promising to be used for multiplexed protein profiling on tissue sections. However, non-specific binding of NPs onto the tissue specimens greatly hampers their clinical applications. In this study, we found that the antigen retrieval method strongly influences the extent of non-specific binding of the antibody-SERS NP conjugates to the tissue...
November 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29147646/creation-and-pilot-testing-of-cases-for-case-based-learning-a-pedagogical-approach-for-pathology-cancer-diagnosis
#9
Shahin Sayed, Susan C Lester, Michael Wilson, Daniel Berney, Ricard Masia, Zahir Moloo, Jennifer Stall, Alexia Eslan, Stephanie Ayers, Angela Mutuku, Jeannette Guarner
Background: Case-based learning (CBL) is an established pedagogical active learning method used in various disciplines and defined based on the field of study and type of case. The utility of CBL for teaching specific aspects of cancer diagnosis to practising pathologists has not been previously studied in sub-Saharan Africa. Objectives: We aimed to pilot test standardised cancer cases on a group of practising pathologists in sub-Saharan Africa to evaluate case content, clarity of questions and delivery of content...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/29147082/impact-of-pathology-review-for-decision-therapy-in-localized-prostate-cancer
#10
Pedro Luiz Serrano Usón, Ricardo Silvestre E Silva Macarenco, Fernando Nunes Oliveira, Oren Smaletz
Background: The Gleason score is an essential tool in the decision to treat localized prostate cancer. However, experienced pathologists can classify Gleason score differently than do low-volume pathologists, and this may affect the treatment decision. This study sought to assess the impact of pathology review of external biopsy specimens from 23 men with a recent diagnosis of localized prostate cancer. Methods: All external biopsy specimens were reviewed at our pathology department...
2017: Clinical Medicine Insights. Pathology
https://www.readbyqxmd.com/read/29145346/role-of-delayed-time-point-imaging-during-abdominal-and-pelvic-cancer-screening-using-fdg-pet-ct-in-the-general-population
#11
Shotaro Naganawa, Takeharu Yoshikawa, Koichiro Yasaka, Eriko Maeda, Naoto Hayashi, Osamu Abe
Although delayed-time-point imaging is expected to improve the results of [F]-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT), how examinees will benefit from dual-time-point imaging versus initial-time-point imaging alone, remains unclear. This study investigated the role of delayed-time-point imaging in improving the results of abdominal and pelvic cancer screening using FDG-PET/CT.This retrospective review included 3131 screening results (average subject age: 55.5 years, range: 40-88 years)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143253/ruling-out-clinically-significant-prostate-cancer-with-negative-multi-parametric-mri
#12
Julie Y An, Abhinav Sidana, Sarah A Holzman, Joseph A Baiocco, Sherif Mehralivand, Peter L Choyke, Bradford J Wood, Baris Turkbey, Peter A Pinto
PURPOSE: To evaluate the negative predictive value (NPV) of a negative prostate multi-parametric magnetic resonance imaging (mpMRI) in ruling out clinically significant prostate upon 12-core systematic biopsy. METHODS: We retrospectively reviewed 114 men evaluated at our institution who underwent systematic 12-core biopsy within 1 year of a negative prostate mpMRI. Clinicopathologic features were evaluated and NPV was calculated for detection of clinically significant (Gleason ≥ 7) cancer...
November 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29141559/new-histopathological-genetic-features-to-improve-active-surveillance-selection-for-low-risk-prostate-cancer
#13
Lih-Ming Wong, Kevin Chu, Niall Corcoran, Sam Norden
BACKGROUND: A recent surge in biomarkers to aid management of men with prostate cancer has occurred. Their applications are varied and not all tests are applicable to the active surveillance setting. OBJECTIVE: To review primary evidence on genetic and immunohistochemical biomarkers, and their role on patient selection and risk stratification for men on active surveillance for prostate cancer. EVIDENCE ACQUISITION: A PubMed electronic search using the terms (biomarker or genetic or histopathological) AND ("prostate cancer" AND "active surveillance") was performed from inception to April 2015...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29140118/-11-c-choline-pet-ct-for-detection-and-localization-of-parathyroid-adenomas
#14
Ahmad Parvinian, Erica L Martin-Macintosh, Ajit H Goenka, Jolanta M Durski, Brian P Mullan, Brad J Kemp, Geoffrey B Johnson
OBJECTIVE: The purpose of this study is to determine the efficacy of (11)C-choline PET/CT for the detection of parathyroid adenomas by retrospectively reviewing a large patient population. MATERIALS AND METHODS: In this single-institution retrospective study, 7088 (11)C-choline PET/CT scans performed of 2933 men with prostate cancer from January 2005 through February 2016 were evaluated. Patients with suspected parathyroid adenomas were identified through a review of the electronic medical record and relevant imaging...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29139652/liposarcoma-of-the-spermatic-cord-%C3%A2-a-rare-pathological-entity
#15
Nikola Radović, Arianna Bizatzki, Rajka Turner
Liposarcoma of the spermatic cord is a very rare neoplasm with fewer than 200 cases recorded in world literature. This report describes a case of liposarcoma of the spermatic cord which developed after radical prostatectomy and salvage radiotherapy for prostate cancer treatment. Four years following surgical treatment of the primary neoplasm and one year following radiotherapy, the 67 –year –old patient was referred to the urology clinic for the emergence of a mass in the right hemiscrotum region. Ultrasonography revealed a homogenous isodense mass measuring 4...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29138842/placenta-specific-protein-1-promotes-cell-proliferation-and-invasion-in-non-small-cell-lung-cancer
#16
Li Yang, Tian-Qi Zha, Xiang He, Liang Chen, Quan Zhu, Wei-Bing Wu, Feng-Qi Nie, Qian Wang, Chong-Shuang Zang, Mei-Ling Zhang, Jing He, Wei Li, Wen Jiang, Kai-Hua Lu
Pulmonary carcinoma-associated proteins have emerged as crucial players in governing fundamental biological processes such as cell proliferation, apoptosis and metastasis in human cancers. Placenta-specific protein 1 (PLAC1) is a cancer-related protein, which is activated and upregulated in a variety of malignant tissues, including prostate cancer, gastric adenocarcinoma, colorectal, epithelial ovarian and breast cancer. However, its biological role and clinical significance in non-small cell lung cancer (NSCLC) development and progression are still unknown...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29138507/systems-pathology-by-multiplexed-immunohistochemistry-and-whole-slide-digital-image-analysis
#17
Sami Blom, Lassi Paavolainen, Dmitrii Bychkov, Riku Turkki, Petra Mäki-Teeri, Annabrita Hemmes, Katja Välimäki, Johan Lundin, Olli Kallioniemi, Teijo Pellinen
The paradigm of molecular histopathology is shifting from a single-marker immunohistochemistry towards multiplexed detection of markers to better understand the complex pathological processes. However, there are no systems allowing multiplexed IHC (mIHC) with high-resolution whole-slide tissue imaging and analysis, yet providing feasible throughput for routine use. We present an mIHC platform combining fluorescent and chromogenic staining with automated whole-slide imaging and integrated whole-slide image analysis, enabling simultaneous detection of six protein markers and nuclei, and automatic quantification and classification of hundreds of thousands of cells in situ in formalin-fixed paraffin-embedded tissues...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137875/contribution-of-11-c-choline-pet-ct-in-prostate-carcinoma-biochemical-relapse-with-serum-psa-level-below-1-ng-ml
#18
F J Gómez-de la Fuente, I Martínez-Rodríguez, M de Arcocha-Torres, R Quirce, J Jiménez-Bonilla, N Martínez-Amador, I Banzo
OBJECTIVE: (11)C-choline PET/CT has demonstrated good results in the restaging of prostate cancer (PCa) with high serum prostate specific antigen (PSA), but its use in patients with low serum PSA is controversial. Our aim was to evaluate the contribution of (11)C-choline PET/CT in patients with PCa, biochemical relapse and PSA <1 ng/ml. MATERIAL AND METHOD: Fifty consecutive patients (mean age: 65.9±5.6 years) with biochemical relapse of PCa and serum PSA <1ng/ml were evaluated retrospectively...
November 11, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29136019/comparative-rates-of-upstaging-and-upgrading-in-caucasian-and-korean-prostate-cancer-patients-eligible-for-active-surveillance
#19
Hwang Gyun Jeon, Jae Ho Yoo, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Han-Yong Choi, Hyun Moo Lee, Michelle Ferrari, James D Brooks, Benjamin I Chung
PURPOSE: To investigate the impact of race on the risk of pathological upgrading and upstaging at radical prostatectomy (RP) in an Asian (Korean) and Western (Caucasian) cohort eligible for active surveillance (AS). MATERIALS AND METHODS: We performed a retrospective cohort study of 854 patients eligible for AS who underwent RP in United States (n = 261) and Korea (n = 593) between 2006 and 2015. After adjusting for age, PSA level, and prostate volume, we utilized multivariate logistic regression analysis to assess the effect of race on upgrading or upstaging...
2017: PloS One
https://www.readbyqxmd.com/read/29134670/altered-mitochondrial-genome-content-signals-worse-pathology-and-prognosis-in-prostate-cancer
#20
Anton M F Kalsbeek, Eva K F Chan, Judith Grogan, Desiree C Petersen, Weerachai Jaratlerdsiri, Ruta Gupta, Ruth J Lyons, Anne-Maree Haynes, Lisa G Horvath, James G Kench, Phillip D Stricker, Vanessa M Hayes
BACKGROUND: Mitochondrial genome (mtDNA) content is depleted in many cancers. In prostate cancer, there is intra-glandular as well as inter-patient mtDNA copy number variation. In this study, we determine if mtDNA content can be used as a predictor for prostate cancer staging and outcomes. METHODS: Fresh prostate cancer biopsies from 115 patients were obtained at time of surgery. All cores underwent pathological review, followed by isolation of cancer and normal tissue...
November 14, 2017: Prostate
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