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https://www.readbyqxmd.com/read/29340839/the-cumulative-incidence-and-risk-factors-of-postoperative-inguinal-hernia-in-patients-undergoing-radical-prostatectomy
#1
Ja Yoon Ku, Chan Ho Lee, Won Young Park, Nam Kyung Lee, Seung Hyun Baek, Hong Koo Ha
BACKGROUND: The aim of this study is to investigate the cumulative incidence and risk factors of postoperative inguinal hernia (PIH) in patients undergoing radical prostatectomy, i.e., laparoscopic prostatectomy (LRP) and robot-assisted laparoscopic prostatectomy (RARP). METHODS: This study included 1124 patients who had undergone radical prostatectomy or transurethral resection of bladder tumor from 2011-2016. We compared the cumulative incidence of PIH in the radical prostatectomy groups (460; LRP 341, RARP 119) and the control group (664; transurethral resection of bladder tumor), and we then analyzed the risk factors (age, operative methods, previous abdominal operative history, thickness and width of external oblique muscle and rectus muscle, thickness of abdominal subcutaneous fat layer at Hesselbach's triangle level, body mass index, prostate-specific antigen, operative time, specimen weight, Gleason score, and pathology T-stage) of PIH in the radical prostatectomy groups...
January 16, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29339090/patched-1-expression-correlates-with-biochemical-relapse-in-high-risk-prostate-cancer-patients
#2
Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M McKee, Filip Van Utterbeeck, Evelyne Lerut, Clare Verrill, Richard J Bryant, Steven Joniau, Ruth J Muschel, Karin Haustermans
There is an unmet clinical need for adequate biomarkers to aid risk stratification and management of prostate cancer (PCa) patients. Even within the high-risk PCa category not all patients will invariably have a poor prognosis, and improved stratification of this heterogeneous group is needed. In this context, components of the hedgehog (Hh) pathway may have promise as biomarkers, as the available evidence suggests increased Hh pathway activity may confer a poorer outcome in advanced and castrate-resistant PCa...
January 12, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29336979/prostate-magnetic-resonance-imaging-the-truth-lies-in-the-eye-of-the-beholder
#3
Joseph C Riney, Nabeel E Sarwani, Shehzad Siddique, Jay D Raman
PURPOSE: To determine the diagnostic accuracy and interobserver variability of radiologic interpretation of magnetic resonance imaging (MRI) performed for surgical planning before prostatectomy. PATIENTS AND METHODS: The records of 233 men undergoing prostatectomy with presurgical multiparametric 3T surface body coil MRI were reviewed. All initial films were read by a fellowship-trained body radiologist provided with relevant clinical information. A senior radiologist then reread all pelvic MRIs blinded to the initial interpretation with findings from both readings compared to final pathology...
January 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29336835/standard-whole-prostate-gland-radiotherapy-with-and-without-lesion-boost-in-prostate-cancer-toxicity-in-the-flame-randomized-controlled-trial
#4
Evelyn M Monninkhof, Juliette W L van Loon, Marco van Vulpen, Linda G W Kerkmeijer, Floris J Pos, Karin Haustermans, Laura van den Bergh, Sofie Isebaert, Gill M McColl, Robert Jan Smeenk, Juus Noteboom, Iris Walraven, Petra H M Peeters, Uulke A van der Heide
PURPOSE: To compare toxicity rates in patients with localized prostate cancer treated with standard fractionated external beam radiotherapy (EBRT) with or without an additional integrated boost to the macroscopically visible tumour. MATERIAL AND METHODS: FLAME is a phase 3 multicentre RCT (NCT01168479) of patients with pathologically confirmed localized intermediate or high-risk prostate cancer. The standard treatment arm (n = 287) received a dose to the entire prostate of 77 Gy in 35 fractions...
January 11, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29334632/capillary-electrophoresis-mass-spectrometry-for-targeted-and-untargeted-analysis-of-the-sub-5%C3%A2-kda-urine-metabolome-of-patients-with-prostate-or-bladder-cancer-a-feasibility-study
#5
Matthew S MacLennan, Miranda G M Kok, Laiel Soliman, Alan So, Antonio Hurtado-Coll, David D Y Chen
Targeted and untargeted analyses of the sub-5 kDa urine metabolome of genitourinary cancer patients (prostate and/or bladder) were performed without chemical derivatization using capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS). For targeted analysis, endogenous levels of sarcosine and 5 other amino acid metabolites implicated in the progression of prostate cancer were quantified in four patients and in a pooled urine sample from healthy volunteers. An untargeted analysis (m/z 50 to 850) of patient urine was performed using the same CE-ESI-MS system identifying over 400 distinct molecular features per patient...
January 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29333958/focal-mri-guided-salvage-high-dose-rate-brachytherapy-in-patients-with-radiorecurrent-prostate-cancer
#6
Metha Maenhout, Max Peters, Marco van Vulpen, Marinus A Moerland, Richard P Meijer, Maurice A A J van den Bosch, Paul L Nguyen, Steven J Frank, Jochem R N van der Voort van Zyp
INTRODUCTION: Whole-gland salvage treatment of radiorecurrent prostate cancer has a high rate of severe toxicity. The standard of care in case of a biochemical recurrence is androgen deprivation treatment, which is associated with morbidity and negative effects on quality of life. A salvage treatment with acceptable toxicity might postpone the start of androgen deprivation treatment, might have a positive influence on the patients' quality of life, and might even be curative. Here, toxicity and biochemical outcome are described after magnetic resonance imaging-guided focal salvage high-dose-rate brachytherapy in patients with radiorecurrent prostate cancer...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29333469/utility-of-f-18-fdg-pet-ct-for-detection-of-bone-marrow-metastases-in-prostate-cancer-patients-treated-with-radium-223
#7
Kaoru Maruyama, Keita Utsunomia, Takahiro Nakamoto, Shigenari Kawakita, Takashi Murota, Noboru Tanigawa
A 76-year-old man with symptomatic bone metastases from castration-resistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or relapse. Some lesions showed decrease and some lesions showed increase on Tc-99m hydroxymethylene diphosphonate bone scintigraphy at two weeks after the third injection of Ra-223 therapy...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29330107/prostate-cancer-associated-lncrnas
#8
Yuichi Mitobe, Ken-Ichi Takayama, Kuniko Horie-Inoue, Satoshi Inoue
Long non-coding RNA (LncRNA) is defined as an RNA transcript that does not encode any protein, with a length longer than 200 nt. Based on the recent advances in high-throughput sequencing techniques, a large number of lncRNAs have been characterized as functional transcripts that play important roles in various biological processes as well as pathologic states. In a research field of prostate cancer, several key lncRNAs have been identified as new players that contribute to the pathophysiology of the disease, which is primarily regulated by androgen and its cognate receptor...
January 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29327138/handling-and-reporting-of-transperineal-template-prostate-biopsy-in-europe-a-web-based-survey-by-the-european-network-of-uropathology-enup
#9
Solene-Florence Kammerer-Jacquet, Eva Compérat, Lars Egevad, Ondra Hes, Jon Oxley, Murali Varma, Glen Kristiansen, Daniel M Berney
Transperineal template prostate biopsies (TTPB) are performed for assessments after unexpected negative transrectal ultrasound biopsies (TRUSB), correlation with imaging findings and during active surveillance. The impact of TTPBs on pathology has not been analysed. The European Network of Uropathology (ENUP) distributed a survey on TTPB, including how specimens were received, processed and analysed. Two hundred forty-four replies were received from 22 countries with TTPBs seen by 68.4% of the responders (n = 167)...
January 11, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29325693/updates-in-the-eighth-edition-of-the-tumor-node-metastasis-staging-classification-for-urologic-cancers
#10
REVIEW
Gladell P Paner, Walter M Stadler, Donna E Hansel, Rodolfo Montironi, Daniel W Lin, Mahul B Amin
The Tumor-Node-Metastasis (TNM) classification on cancer staging, jointly developed by the American Joint Commission on Cancer (AJCC) and the Union for International Cancer Control (UICC), has been updated to its 8th edition with two contemporaneous versions published by the AJCC and UICC. While the goal of the AJCC and UICC is to have identical TNM staging systems, differences exist between these two publications including in the staging of urologic cancers. Among several new facets in the AJCC staging manual, a select few of greater import include an expanded section on imaging, presentation of levels of evidence for significant changes, and endorsement of risk assessment models that pass the AJCC quality criteria such as in prostate cancer...
January 8, 2018: European Urology
https://www.readbyqxmd.com/read/29325321/-preliminary-applicability-evaluation-of-prostate-imaging-reporting-and-data-system-version-2-diagnostic-score-in-3-0t-multi-parameters-magnetic-resonance-imaging-combined-with-prostate-specific-antigen-density-for-prostate-cancer
#11
M Z Zuo, W L Zhao, C G Wei, C Y Zhang, R Wen, Y F Gu, M J Li, Y Y Zhang, J F Wu, X Li, J K Shen
Objective: To investigate the preliminary applicability of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) score in the condition of 3.0T multi-parametric magnetic resonance imaging (Mp-MRI) combined with clinical classic indicators for the diagnosis of prostate cancer (PCa). Methods: The clinical and MRI materials of 247 patients of suspicious prostate disease treated in Second Affiliated Hospital of Soochow University from June 2015 to November 2016 were analyzed retrospectively, including 110 cases with PCa and 137 cases without cancer...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29320570/image-guided-whole-pelvic-intensity-modulated-radiotherapy-for-biochemical-recurrence-following-radical-prostatectomy-in-high-risk-prostate-cancer-patients
#12
Sang Jun Byun, Young Seok Kim, Hanjong Ahn, Choung-Soo Kim
BACKGROUND: The optimal field size of salvage radiotherapy (SRT) for biochemical recurrence, particularly for patients with high-risk prostate cancer, remains undefined. This retrospective analysis was performed to investigate oncological outcomes as well as treatment-related toxicity following salvage intensity-modulated radiotherapy (IMRT) to the whole pelvis and to compare the results with other studies implementing a small field size of the prostate bed. METHODS: The medical records of 170 patients with high-risk prostate cancer who received SRT for biochemical recurrence following prostatectomy were reviewed...
2018: PloS One
https://www.readbyqxmd.com/read/29317377/multiparametric-mri-for-the-detection-of-local-recurrence-of-prostate-cancer-in-the-setting-of-biochemical-recurrence-after-low-dose-rate-brachytherapy
#13
Luca F Valle, Matthew D Greer, Joanna H Shih, Tristan Barrett, Yan Mee Law, Andrew B Rosenkrantz, Haytham Shebel, Akhil Muthigi, Daniel Su, Maria J Merino, Bradford J Wood, Peter A Pinto, Andra V Krauze, Aradhana Kaushal, Peter L Choyke, Barış Türkbey, Deborah E Citrin
PURPOSE: Prostate multiparametric magnetic resonance imaging (mpMRI) has utility in detecting post-radiotherapy local recurrence. We conducted a multireader study to evaluate the diagnostic performance of mpMRI for local recurrence after low dose rate (LDR) brachytherapy. METHODS: A total of 19 patients with biochemical recurrence after LDR brachytherapy underwent 3T endorectal coil mpMRI with T2-weighted imaging, dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI) with pathologic confirmation...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29316844/pi3k-pathway-and-bcl-2-family-clinicopathological-features-in-prostate-cancer
#14
Norelia Torrealba, Gonzalo Rodriguez-Berriguete, Benito Fraile, Gabriel Olmedilla, Pilar Martínez-Onsurbe, Manuel Sánchez-Chapado, Ricardo Paniagua, Mar Royuela
The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathways and Bcl-2 family play a central role in prostate cancer (PC). The aim was to determine influence in the biochemical progression in PC. To evaluate the association between clinic pathological and immunohistochemical variables, Spearman's test was performed. Log-rank test and Kaplan-Meier curves were used for survival comparisons. To explore the correlation of the studied immunohistochemical parameters and the established prognostic variables with biochemical progression, univariate and multivariate Cox proportional Hazard regression analyses were performed...
January 9, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29315854/predictive-factors-of-biochemical-recurrence-after-radical-prostatectomy-for-high-risk-prostate-cancer
#15
Yukiko Murata, Katsunori Tatsugami, Masahiro Yoshikawa, Masumitsu Hamaguchi, Shigetomo Yamada, Yusuke Hayakawa, Kouhei Ueda, Seiya Momosaki, Naotaka Sakamoto
OBJECTIVE: To identify risk factors of biochemical recurrence after radical prostatectomy in high-risk patients. METHODS: A total of 191 high-risk prostate cancer patients according to the D'Amico classification treated with radical prostatectomy at a single institution between April 2000 and December 2013 were enrolled. The pathological evaluation including intraductal carcinoma of prostate was reassessed, and the clinical and pathological risk factors of biochemical recurrence were analyzed...
January 8, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29314004/role-of-wnt-signalling-in-advanced-prostate-cancer
#16
Imran Ahmad, Owen J Sansom
Recent next-generation-sequencing studies demonstrate that multiple pathways are often deregulated in advanced and metastatic prostate cancer (PC). In a recent issue of The Journal of Pathology, an elegant study by Jefferies et al used in vivo modelling to demonstrate how activation of the PI3K, WNT and MAPK pathway converges on mTORC1 signalling to drive aggressive disease. The study also highlights that approaches to target advanced PC require intelligent combination of agents to target single/multiple signalling pathways in combination with androgen receptor (AR) blockade...
January 4, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29306731/the-impact-of-lymph-node-metastases-burden-at-radical-prostatectomy
#17
Felix Preisser, Michele Marchioni, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Raisa S Pompe, Francesco Montorsi, Fred Saad, Firas Abdollah, Thomas Steuber, Hans Heinzer, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: We hypothesized that a cut-off in positive lymph node (LN) counts may discriminate between cancer-specific mortality (CSM) rates in clinically localized prostate cancer patients treated with radical prostatectomy (RP). OBJECTIVE: To test this relationship, we relied on different LN count cut-offs, as well as the continuously coded number of positive LNs (NPN). METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2014), we identified patients with D'Amico intermediate- or high-risk characteristics who underwent RP and pelvic LN dissection, regardless of pathologic LN stage...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29306730/role-of-metabolic-syndrome-on-perioperative-and-oncological-outcomes-at-radical-prostatectomy-in-a-low-risk-prostate-cancer-cohort-potentially-eligible-for-active-surveillance
#18
Michele Colicchia, Alessandro Morlacco, Laureano J Rangel, Rachel E Carlson, Fabrizio Dal Moro, R Jeffrey Karnes
BACKGROUND: Metabolic syndrome (MetS) is considered a potential risk factor for adverse outcomes after radical prostatectomy (RP). Furthermore, studies about the effect of MetS on low-risk prostate cancer (PCa) and its implications in active surveillance (AS) are limited. OBJECTIVE: To investigate the role of MetS (using International Diabetes Federation-American Heart Association/National Heart, Lung, and Blood Institute criteria) on perioperative and oncological outcomes after RP in low-risk PCa and in a subgroup potentially eligible for AS...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29306514/intermediate-endpoints-after-postprostatectomy-radiotherapy-5-year-distant-metastasis-to-predict-overall-survival
#19
William C Jackson, Krithika Suresh, Vasu Tumati, Steven G Allen, Robert T Dess, Simpa S Salami, Arvin George, Samuel D Kaffenberger, David C Miller, Jason W D Hearn, Shruti Jolly, Rohit Mehra, Brent K Hollenbeck, Ganesh S Palapattu, Matthew Schipper, Felix Y Feng, Todd M Morgan, Neil B Desai, Daniel E Spratt
BACKGROUND: Intermediate clinical endpoints (ICEs) prognostic for overall survival (OS) are needed for men receiving postprostatectomy radiation therapy (PORT) to improve clinical trial design. OBJECTIVE: To identify a potential ICE for men receiving PORT. DESIGN, SETTING, AND PARTICIPANTS: We performed an institutional review board-approved multi-institutional retrospective study of 566 men consecutively treated with PORT at tertiary care centers from 1986 to 2013...
January 3, 2018: European Urology
https://www.readbyqxmd.com/read/29306150/ultrasonographic-assessment-of-the-male-koala-phascolarctos-cinereus-reproductive-tract
#20
Rebecca Larkin, Chiara Palmieri, Motoharu Oishi, Lyndal Hulse, Stephen D Johnston
Studies documenting the application of ultrasonography to depict normal and pathological changes in koalas (Phascolarctos cinereus), especially in the male, are scarce. Sixty-two wild koalas were used in this study to define ultrasonographic protocols and features for the assessment of the male koala reproductive tract. Testis, epididymis and spermatic cord were examined using a hockey stick transducer. The normal koala testis showed a homogeneous echogenicity and an obvious hyper-echoic band corresponding to the tunica albuginea...
December 27, 2017: Research in Veterinary Science
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