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https://www.readbyqxmd.com/read/28942009/comparison-of-11-active-surveillance-protocols-in-contemporary-european-men-treated-with-radical-prostatectomy
#1
Sami-Ramzi Leyh-Bannurah, Pierre I Karakiewicz, Paolo Dell'Oglio, Alberto Briganti, Jonas Schiffmann, Raisa S Pompe, Guido Sauter, Thorsten Schlomm, Hans Heinzer, Hartwig Huland, Markus Graefen, Lars Budäus
BACKGROUND: The aim of this study was to compare 11 active surveillance (AS) protocols in contemporary European men treated with radical prostatectomy (RP) at the Martini-Clinic Prostate Cancer Center. PATIENTS AND METHODS: Analyzed were 3498 RP patients, from 2005 to 2016, who underwent ≥ 10 core biopsies and fulfilled at least 1 of 11 examined AS entry definitions. We tested proportions of AS eligibility, ineligibility, presence of primary Gleason 4/5, upstage, and combinations thereof at RP, as well as 5-year biochemical recurrence-free survival (BFS)...
August 31, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28941923/validation-of-gemcap-as-a-dna-based-biomarker-to-predict-prostate-cancer-recurrence-after-radical-prostatectomy
#2
Hao G Nguyen, Christopher Welty, Karla Lindquist, Vy Ngo, Elizabeth Gilbert, Henrik Bengtsson, Cristina Magi-Galluzzi, Jerome Jean-Gilles, Jorge Yao, Matthew Cooperberg, Edward Messing, Eric A Klein, Peter R Carroll, Pamela L Paris
PURPOSE: We aim to validate the Genomic Evaluators of Metastatic Cancer of the Prostate (GEMCaP) as a novel copy number signature predictive for prostate cancer recurrence. MATERIALS AND METHODS: We randomly selected patients who had radical prostatectomy at the Cleveland Clinic (CC) or the University of Rochester (UR) from 2000-2005. DNA isolated from the cancer region was extracted and subjected to high resolution array comparative genomic hybridization (aCGH)...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941920/genomic-scores-are-independent-of-disease-volume-in-men-with-favorable-risk-prostate-cancer-implications-for-choosing-men-for-active-surveillance
#3
Yaw A Nyame, Dominic C Grimberg, Daniel J Greene, Karishma Gupta, Ganesh K Kartha, Ryan Berglund, Michael Gong, Andrew J Stephenson, Cristina Magi-Galluzzi, Eric A Klein
OBJECTIVE: To determine if disease volume at prostate biopsy correlates with genomic scores among men with favorable risk prostate cancer. METHODS: All men with NCCN very low (VLR) and low risk (LR) disease and OncotypeDx Prostate testing at our institution from 2013 to 2016 were identified. Volume of disease was characterized as percent of positive cores, number of cores with >50% involvement, largest involvement of any single core, and PSA density. Nonparametric testing was performed to compare the median genomic prostate score (GPS) and likelihood of favorable pathology (LFP) between quartiles of disease volume...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941030/quality-of-life-following-brachytherapy-or-bilateral-nerve-sparing-robotic-prostatectomy-for-prostate-cancer-a-prospective-cohort
#4
Pierre Blanchard, John W Davis, Steven J Frank, Jeri Kim, Curtis A Pettaway, Thomas J Pugh, Louis L Pisters, John F Ward, Seungtaek Choi, Brian F Chapin, Karen Hoffman, Neema Navai, Mary Achim, Sean E McGuire, Surena F Matin, Quynh Nguyen, Usama Mahmood, William J Graber, Hsiang-Chun Chen, Xuemei Wang, Deborah A Kuban
BACKGROUND: Quality of life (QoL) has become an important issue in cancer care. Better data on QoL after prostate cancer treatment could help patients make an informed decision regarding the treatment of their choice. METHODS: Pathologically proven, non-metastatic, T1-T3bN0 prostate cancer patients were included in this prospective non-randomized study if they were to receive curative intent treatment. Sample size was at least 181 patients per cohort/treatment type...
September 20, 2017: BJU International
https://www.readbyqxmd.com/read/28939976/a-novel-biopsy-related-parameter-derived-from-location-and-relationship-of-positive-cores-on-standard-12-core-trans-rectal-ultrasound-guided-prostate-biopsy-a-useful-parameter-for-predicting-tumor-volume-compared-to-number-of-positive-cores
#5
Sangjun Yoo, Hwancheol Son, Sohee Oh, Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong
PURPOSE: To develop a novel biopsy-related parameter, named overlapping line, defined as the line between the adjacent positive cores on 12-core trans-rectal ultrasound-guided prostate biopsy, and evaluated the value of overlapping line for predicting tumor volume in the final pathologic examination. METHODS: Among patients with prostate cancer who underwent radical prostatectomy at Boramae Medical Center, 470 patients who underwent standard 12-core trans-rectal ultrasound-guided prostate biopsy were selected for the analysis...
September 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28939770/myristoylation-of-src-kinase-mediates-src-induced-and-high-fat-diet-accelerated-prostate-tumor-progression-in-mice
#6
Sungjin Kim, Xiangkun Yang, Qianjin Li, Meng Wu, Leah Costyn, Zanna Beharry, Michael G Bartlett, Houjian Cai
Exogenous fatty acids provide substrates for energy production and the biogenesis of the cytoplasmic membrane, but they also enhance cellular signaling during cancer cell proliferation. However, it remains controversial whether dietary fatty acids are correlated with tumor progression. In this study, we demonstrate that increased Src kinase activity is associated with high fat diet accelerated progression of prostate tumors and that Src kinases mediate this pathological process. Moreover, in the in vivo prostate regeneration assay, host SCID mice carrying Src(Y529F) transduced regeneration tissues were fed with a low fat diet or a high fat diet and treated with vehicle or dasatinib...
September 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28939472/patterns-of-care-of-node-positive-prostate-cancer-patients-across-the-united-states-a-national-cancer-data-base-analysis
#7
Dominic H Moon, Ram S Basak, Ronald C Chen
BACKGROUND: Twelve percent of newly diagnosed prostate cancers in the United States are node-positive. In a setting of disparate treatment guideline recommendations for node-positive disease, this study describes the treatment patterns for clinical node-positive (cN(+)) and pathologic node-positive (pN(+)) patients across the United States. MATERIALS AND METHODS: Using the National Cancer Data Base, men diagnosed with cN(+) or pN(+) disease were identified from 2006 to 2011. For each cohort, the proportion of patients who received radiotherapy (RT), androgen deprivation therapy (ADT), and other treatments was analyzed...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28939336/-evaluation-and-results-of-ablative-therapies-in-prostate-cancer
#8
R Renard-Penna, R Sanchez-Salas, E Barret, J M Cosset, S de Vergie, J Sapetti, A Ingels, A Gangi, H Lang, X Cathelineau
OBJECTIVE: To perform a state of the art about methods of evaluation and present results in ablative therapies for localized prostate cancer. METHODS: A review of the scientific literature was performed in Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of keywords. Publications obtained were selected based on methodology, language and relevance. After selection, 102 articles were analysed. RESULTS: Analyse the results of ablative therapies is presently difficult considering the heterogeneity of indications, techniques and follow-up...
September 19, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28939004/the-phase-3-cou-aa-302-study-of-abiraterone-acetate-plus-prednisone-in-men-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer-stratified-analysis-based-on-pain-prostate-specific-antigen-and-gleason-score
#9
Kurt Miller, Joan Carles, Jürgen E Gschwend, Hendrik Van Poppel, Joris Diels, Sabine D Brookman-May
BACKGROUND: In the COU-AA-302 study (NCT00887198), abiraterone acetate plus prednisone (AAP) significantly improved outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC) versus prednisone alone. Baseline clinical parameters predicting that treatment response could help inform clinical decisions were explored. OBJECTIVE: To identify patients who derive the greatest clinical benefit from AAP treatment. DESIGN, SETTING, AND PARTICIPANTS: A total of 1088 mCRPC patients treated with either AAP or prednisone in the first-line setting in COU-AA-302 were included in this post hoc analysis...
September 19, 2017: European Urology
https://www.readbyqxmd.com/read/28938519/gilaburu-viburnum-opulus-l-fruit-extract-alleviates-testis-and-sperm-damages-induced-by-taxane-based-chemotherapeutics
#10
Serpil Sarıözkan, Gaffari Türk, Ayşe Eken, Latife Çakır Bayram, Ayşe Baldemir, Gülden Doğan
In this study, it was aimed to investigate the possible protective effects of gilaburu (Viburnum opulus L., Glb) fruit extract on testis and sperm damages induced by docetaxel (DTX) and paclitaxel (PTX) chemotherapeutics in rats. Sixty adult male Wistar albino rats were divided into 6 equal groups, 10 animals each. The groups were created as control (weekly i.p. saline injection), Glb (weekly i.p. saline injection and daily oral 100mg/kg Glb), DTX (weekly i.p. injection of 5mg/kg DTX), PTX (weekly i.p. injection of 4mg/kg PTX), DTX+Glb (weekly i...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28932949/twenty-first-century-cancer-patterns-in-small-island-nations-grenada-and-the-english-speaking-caribbean
#11
Lindsay M Cattin, Paulo S Pinheiro, Karen E Callahan, Robert Hage
PURPOSE: Grenada is a small island nation of 105,000 in the Caribbean with one single general hospital and pathology laboratory. This study assesses cancer incidence on the island based on existing pathology reports, and compares the cancer mortality burden between Grenada and other Caribbean nations. METHODS: Age-adjusted overall and site-specific cancer "incidence" rates (based on pathology reports) and mortality rates were calculated and compared for 2000-2009...
September 20, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28930171/comprehensive-evaluation-of-tff3-promoter-hypomethylation-and-molecular-biomarker-potential-for-prostate-cancer-diagnosis-and-prognosis
#12
Maibritt Nørgaard, Christa Haldrup, Tine Maj Storebjerg, Else Marie Vestergaard, Peter J Wild, Søren Høyer, Michael Borre, Torben Falck Ørntoft, Karina Dalsgaard Sørensen
Overdiagnosis and overtreatment of clinically insignificant tumors remains a major problem in prostate cancer (PC) due to suboptimal diagnostic and prognostic tools. Thus, novel biomarkers are urgently needed. In this study, we investigated the biomarker potential of Trefoil factor 3 (TFF3) promoter methylation and RNA expression levels for PC. Initially, by quantitative methylation specific PCR (qMSP) analysis of a large radical prostatectomy (RP) cohort (n = 292), we found that the TFF3 promoter was significantly hypomethylated in PC compared to non-malignant (NM) prostate tissue samples (p < 0...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28929838/the-influence-of-nutritional-factors-on-prostate-cancer-incidence-and-aggressiveness
#13
Manrique Pascual-Geler, Noelia Urquiza-Salvat, Jose Manuel Cozar, Inmaculada Robles-Fernandez, Ana Rivas, Luis Javier Martinez-Gonzalez, Francisco Manuel Ocaña-Peinado, Jose Antonio Lorente, Maria Jesus Alvarez-Cubero
There is an increasing evidence for a link between nutrition, lifestyle and prostate cancer (PCa) development and/or progression of disease. The objective of this study was to examine the association between dietary factors and PCa incidence and aggressiveness in a case-control study. After the analysis of the anatomic pathology, subjects were classified in patients with PCa (n = 157) and controls (n = 158). Clinical data including Gleason score, PSA values and biopsy results, were compiled. Frequencies of food consumption and sociodemographic data were also obtained...
September 20, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28929505/high-level-glyoxalase-1-glo1-expression-is-linked-to-poor-prognosis-in-prostate-cancer
#14
Christoph Burdelski, Rami Shihada, Andrea Hinsch, Alexander Angerer, Cosima Göbel, Emily Friedrich, Claudia Hube-Magg, Susanne Burdak-Rothkamm, Martina Kluth, Ronald Simon, Christina Möller-Koop, Guido Sauter, Franzika Büscheck, Corinna Wittmer, Till S Clauditz, Till Krech, Maria C Tsourlakis, Sarah Minner, Markus Graefen, Thorsten Schlomm, Waldemar Wilczak, Frank Jacobsen
BACKGROUND: Glyoxalase 1 (GLO1) is an enzyme involved in removal of toxic byproducts accumulating during glycolysis from the cell. GLO1 is up regulated in many cancer types but its role in prostate cancer is largely unknown. METHODS: Here, we employed GLO1 immunohistochemistry on a tissue microarray including 11 152 tumors and an attached clinical and molecular database. RESULTS: Normal prostate epithelium was negative for GLO1, whereas 2059 (27...
September 19, 2017: Prostate
https://www.readbyqxmd.com/read/28928012/frequency-and-prognostic-significance-of-incidental-prostate-cancer-at-radical-cystectomy-results-from-an-international-retrospective-study
#15
Rieken Malte, Luis A Kluth, Dharam Kaushik, Stephen A Boorjian, Mohammad Abufaraj, Beat Foerster, Michael Rink, Kilian Gust, Florian Roghmann, Joachim Noldus, Dimitri Vordos, Masayuki Hagiwara, Eiji Kikuchi, Masaomi Ikeda, Kazumasa Matsumoto, Pierre I Karakiewicz, Morgan Rouprêt, Alberto Briganti, Douglas S Scherr, Shahrokh F Shariat, Veronika Seebacher
OBJECTIVES: To analyze the frequency of incidental prostate cancer (PC) at radical cystoprostatectomy (RC) for urothelial carcinoma of the bladder (UCB) and its association with survival outcomes in an international cohort. PATIENTS AND METHODS: In this retrospective study, we included 2114 who underwent RC and lymphadenectomy for UCB between 1976 and 2012 male patients from seven institutions. Univariable and multivariable Cox regression models addressed the association of incidental PC with cancer-specific mortality and overall mortality after RC...
September 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28927133/benefit-of-rebiopsy-for-deciding-treatment-strategy-in-rectal-cancer-a-case-report
#16
Kenta Kawasaki, Yasuo Hamamoto, Takeshi Suzuki, Kenro Hirata, Yasutaka Sukawa, Akiyoshi Kasuga, Yuichiro Hayashi, Hiromasa Takaishi, Kaori Kameyama, Takanori Kanai
Rebiopsy is considered an option for specific types of cancer, such as breast, non-small cell lung, and prostate cancer, in clinical trials and in practice. The benefit of rebiopsy comes from the selection of a new treatment strategy based on the genetic profile of the cells, which may reflect the development of drug resistance or hormonal changes. For colorectal cancer, the presence of different genomic mutations between the primary tumor and its metastases is rare, and rebiopsy is therefore not generally performed...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924059/pygopus2-expression-in-prostatic-adenocarcinoma-is-a-potential-risk-stratification-marker-for-psa-progression-following-radical-prostatectomy
#17
Kenneth R Kao, Paul Popadiuk, John Thoms, Satoko Aoki, Shahgul Anwar, Emily Fitzgerald, Phillip Andrews, Kim Voisey, Luis Gai, Satya Challa, Zhijian He, Paola Gonzales-Aguirre, Andrea Simmonds, Catherine Popadiuk
AIMS: Prostate cancer (PrCa) is the most frequently diagnosed non-cutaneous cancer in men. Without clear pathological indicators of disease trajectory at diagnosis, management of PrCa is challenging, given its wide-ranging manifestation from indolent to highly aggressive disease. This study examines the role in PrCa of the Pygopus (PYGO)2 chromatin effector protein as a risk stratification marker in PrCa. METHODS: RNA expression was performed in PrCa cell lines using Northern and RT-PCR analyses...
September 18, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28922958/post-prostatectomy-radiation-therapy-for-locally-recurrent-prostate-cancer
#18
Sudhir Isharwal, Andrew J Stephenson
Approximately 15-30% of men with localized prostate cancer will experience biochemical recurrence (BCR) after radical prostatectomy. Postoperative radiation therapy is used in men with adverse pathological features to reduce the risk of BCR or with curative intent in men with known BCR. In this study, we review the evidence for the adjuvant and salvage radiation therapy after radical prostatectomy. Areas covered: A literature review of the Medline and Embase databases was performed. The search strategy included the following terms: prostate cancer, adjuvant radiotherapy, salvage radiotherapy, radical prostatectomy, biochemical recurrence, and prostate cancer recurrence...
September 18, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28919182/population-based-study-of-the-incidence-and-survival-for-intraductal-carcinoma-of-the-prostate
#19
Brian F Dinerman, Francesca Khani, Ron Golan, Adrien N Bernstein, Michael F Cosiano, Daniel J Margolis, Jim C Hu
PURPOSE: The degree to which intraductal carcinoma of the prostate (IDC-P) affects clinical course remains poorly understood owing to small sample sizes from single-center studies. We sought to determine prognostic factors and outcomes associated with IDC-P in radical prostatectomy (RP) specimens. MATERIALS AND METHODS: This is a retrospective study of RP during 2004 to 2013 using Surveillance, Epidemiology, and End Results to compare IDC-P with non-IDC-P. The effect of IDC-P on overall and disease-specific survival was assessed using Cox regression with a median follow-up of 4...
September 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28919005/ex-vivo-%C3%AE-h2ax-radiation-sensitivity-assay-in-prostate-cancer-inter-patient-and-intra-patient-heterogeneity
#20
Chiara De-Colle, Ala Yaromina, Joerg Hennenlotter, Howard Thames, Arndt-Christian Mueller, Tim Neumann, Arnulf Stenzl, Marcus Scharpf, Falko Fend, Umberto Ricardi, Michael Baumann, Daniel Zips, Apostolos Menegakis
INTRODUCTION: The aim of the study is to assess inter-patient and intra-patient heterogeneity in tumour cell radiosensitivity using the ex vivo γH2AX assay in prostate cancer specimens. METHODS: Excised specimens from untreated prostate cancer patients were cultivated 24h in media, irradiated ex vivo and fixed after 24h. Residual γH2AX foci were counted and the slope of the dose response was calculated. Intra-patient heterogeneity was studied from three to seven different biopsies...
September 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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