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https://www.readbyqxmd.com/read/27880851/diagnostic-utility-of-pleural-fluid-cell-block-versus-pleural-biopsy-collected-by-flex-rigid-pleuroscopy-for-malignant-pleural-disease-a-single-center-retrospective-analysis
#1
Shion Miyoshi, Shinji Sasada, Takehiro Izumo, Yuji Matsumoto, Takaaki Tsuchida
BACKGROUND: Some trials recently demonstrated the benefit of targeted treatment for malignant disease; therefore, adequate tissues are needed to detect the targeted gene. Pleural biopsy using flex-rigid pleuroscopy and pleural effusion cell block analysis are both useful for diagnosis of malignancy and obtaining adequate samples. The purpose of our study was to compare the diagnostic utility between the two methods among patients with malignant pleural disease with effusion. METHODS: Data from patients who underwent flex-rigid pleuroscopy for diagnosis of pleural effusion suspicious for malignancy at the National Cancer Center Hospital, Japan between April 2011 and June 2014 were retrospectively reviewed...
2016: PloS One
https://www.readbyqxmd.com/read/27817167/post-mortem-computed-tomography-coaxial-cutting-needle-biopsy-to-facilitate-the-detection-of-bacterioplankton-using-pcr-probes-as-a-diagnostic-indicator-for-drowning
#2
Guy N Rutty, Christopher Johnson, Jasmin Amoroso, Claire Robinson, Carina J Bradley, Bruno Morgan
We report for the first time the use of coaxial cutting needle biopsy, guided by post-mortem computed tomography (PMCT), to sample internal body tissues for bacterioplankton PCR analysis to investigate drowning. This technical report describes the biopsy technique, the comparison of the needle biopsy and the invasive autopsy sampling results, as well as the PMCT and autopsy findings. By using this new biopsy sampling approach for bacterioplankton PCR, we have developed on previous papers describing the minimally invasive PMCT approach for the diagnosis of drowning...
November 5, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27774746/prevalence-of-human-papillomavirus-epstein-barr-virus-and-cytomegalovirus-in-fine-needle-aspirates-from-lung-carcinoma-a-case-control-study-with-review-of-literature
#3
Parikshaa Gupta, Dipanjan Haldar, Jasmine Naru, Pranab Dey, Ashutosh Nath Aggarwal, Ranjana Walker Minz, Ritu Aggarwal
BACKGROUND: Oncogenic viruses have recently been allied with lung carcinoma, however, the causal association has not been established till date. The study was conducted to determine the prevalence of high-risk Human papillomavirus (HPV; subtypes 16, 18, 31, 33 and 45), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in lung carcinoma using polymerase chain reaction (PCR) on fine needle aspirates. METHODS: Fine needle aspirates of patients with lung carcinoma were included as cases...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27725467/nab-paclitaxel-gemcitabine-therapy-for-adenosquamous-carcinoma-of-the-pancreas-an-autopsy-case
#4
Kunio Kataoka, Hiroshi Matsubara, Fumihiro Urano, Shozo Okamura, Matsuyoshi Maeda
A male patient aged over 60 years presented with abdominal pain. A solid lesion measuring 7cm was detected in the pancreatic body and tail, along with periaortic lymphadenopathy. Endoscopic ultrasound-guided fine-needle aspiration suggested squamous cell carcinoma. Nab-paclitaxel+gemcitabine therapy was effective;however, tumor progression was noted after the completion of the fourth course, and the patient died from the primary cancer 7 months after the initial consultation. Autopsy led to a definitive diagnosis of adenosquamous carcinoma of the pancreas...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27591912/a-fatal-poisoning-case-by-intravenous-injection-of-bath-salts-containing-acetyl-fentanyl-and-4-methoxy-pv8
#5
Kosei Yonemitsu, Ako Sasao, Satoko Mishima, Yuki Ohtsu, Yoko Nishitani
A man in his 30's was found at home, not breathing. He was admitted to an emergency hospital and the doctor confirmed his death. He had a history of methamphetamine abuse spanning several years, and while fresh needle marks were visible on his arm, the only other autopsy findings indicated an acute death. A small plastic bag containing a pale brown white powder, and a small amount of liquid in a syringe were found at the scene. The police forensic laboratory detected acetyl fentanyl and 4-methoxy PV8 (4-methoxy PHPP) in both the powder and the liquid...
October 2016: Forensic Science International
https://www.readbyqxmd.com/read/27322966/use-of-cytology-as-an-auxiliary-diagnostic-tool-in-autopsies
#6
Luana Andrade, Vitória Lana Massarente, Stéphanie Corradini Tormin, Karina Braga Ribeiro, Geanete Pozzan, Mauro Ajaj Saieg
BACKGROUND: The use of minimally invasive procedures in autopsies such as image-guided fine-needle aspiration may facilitate family acceptance and, therefore, increase the number of postmortem examinations. The objective of the current study was to validate the use of cytology in a prospective set of conventional autopsies. METHODS: All lesions and organs sampled for histological examination were concomitantly evaluated by scrape cytology of exactly the same location...
November 2016: Cancer
https://www.readbyqxmd.com/read/27246178/distribution-and-components-of-interstitial-inflammation-and-fibrosis-in-igg4-related-kidney-disease-analysis-of-autopsy-specimens
#7
Satoshi Hara, Mitsuhiro Kawano, Ichiro Mizushima, Kenichi Harada, Takuma Takata, Takako Saeki, Yoshifumi Ubara, Yasuharu Sato, Michio Nagata
IgG4-related kidney disease (IgG4-RKD) occasionally progresses to chronic renal failure and is pathologically characterized by IgG4-positive lymphoplasmacyte-rich tubulointerstitial nephritis with storiform fibrosis (bird's-eye pattern fibrosis). Although radiology reveals a heterogeneous distribution of affected areas in this disease, their true distribution within the whole kidney is still unknown because of difficulty in estimating this from needle biopsy samples. Using 5 autopsy specimens, the present study histologically characterized the distribution and components of interstitial inflammation and fibrosis in IgG4-RKD...
September 2016: Human Pathology
https://www.readbyqxmd.com/read/27048880/spatial-and-temporal-homogeneity-of-driver-mutations-in-diffuse-intrinsic-pontine-glioma
#8
Hamid Nikbakht, Eshini Panditharatna, Leonie G Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L Ligon, Benjamin Ellezam, Wendy J Ingram, Caedyn Stinson, Andrew S Moore, Katherine E Warren, Jason Karamchandani, Roger J Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, here we analyse 134 specimens from various neuroanatomical structures of whole autopsy brains from nine DIPG patients. Evolutionary reconstruction indicates histone 3 (H3) K27M--including H3.2K27M--mutations potentially arise first and are invariably associated with specific, high-fidelity obligate partners throughout the tumour and its spread, from diagnosis to end-stage disease, suggesting mutual need for tumorigenesis...
April 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27039162/assessment-of-%C3%AE-synuclein-in-submandibular-glands-of-patients-with-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-a-case-control-study
#9
Dolores Vilas, Alex Iranzo, Eduardo Tolosa, Iban Aldecoa, Joan Berenguer, Isabel Vilaseca, Carles Martí, Mónica Serradell, Francisco Lomeña, Llucia Alós, Carles Gaig, Joan Santamaria, Ellen Gelpi
BACKGROUND: The histological feature of Parkinson's disease is the presence of intraneuronal aggregates of phosphorylated α-synuclein (αSyn). In patients with Parkinson's disease, deposits of αSyn are found in the autonomic nerve fibres of the submandibular gland. Since patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) can develop Parkinson's disease and other synucleinopathies, we investigated whether αSyn deposits could also be detected in their submandibular gland nerve fibres...
June 2016: Lancet Neurology
https://www.readbyqxmd.com/read/26913882/the-renal-history-of-fabry-disease
#10
Martina Gaggl, Sarah El-Hadi, Christof Aigner, Gere Sunder-Plassmann
In 1898 William Anderson and Johannes Fabry described the red-purple maculopapular skin lesions characteristic for Fabry disease and also mentioned the presence of proteinuria. Four decades later Maximiliaan Ruiter concluded that angiokeratoma corporis diffusum is the cutaneous manifestation of an inherited systemic internal disease. In 1947 autopsy findings of two cases who died from uraemia revealed sclerosis of glomeruli. At this time the presence of a thesaurismosis was also considered. The first renal needle biopsy in 1958 showed vacuolation and distension of the cells of the glomerular tufts and distal tubules suggestive of a storage disorder...
February 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26799362/peripheral-synucleinopathy-in-early-parkinson-s-disease-submandibular-gland-needle-biopsy-findings
#11
Charles H Adler, Brittany N Dugger, Joseph G Hentz, Michael L Hinni, David G Lott, Erika Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G Walker, Thomas G Beach
INTRODUCTION: Finding a peripheral tissue biopsy site to diagnose early PD would be of value for clinical care, biomarker validation, and as research enrollment criteria. Whereas autopsy and advanced PD studies suggest that the submandibular gland is an important biopsy site, there are no studies in early PD. The aim of this study was to determine whether needle biopsy of the submandibular gland reveals Lewy type alpha-synucleinopathy in early PD. METHODS: Twenty-five early PD (duration < 5 years) and 10 controls underwent transcutaneous needle core biopsies of the submandibular gland...
February 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/26766998/timely-diagnosis-of-pulmonary-artery-tumor-embolism-by-ultrasound-guided-transbronchial-needle-aspiration
#12
Seung Jun Lee, Jinwoo Lee, Su Jong Yu, Hyun Ju Lee, Kyung Ju Kim, Kyoung-Bun Lee, Young Sik Park
Pulmonary artery tumor embolism (PATE) is a rare disease without an established diagnostic method. In an autopsy series, however, the incidence of PATE was relatively high, between 3% and 26% in patients with a solid tumor. Here we report a case of a patient with a massive PATE from hepatocellular carcinoma diagnosed safely and promptly by endobronchial ultrasound-guided transbronchial needle aspiration.
March 2014: Thoracic Cancer
https://www.readbyqxmd.com/read/26756744/prevalence-of-submandibular-gland-synucleinopathy-in-parkinson-s-disease-dementia-with-lewy-bodies-and-other-lewy-body-disorders
#13
Thomas G Beach, Charles H Adler, Geidy Serrano, Lucia I Sue, D G Walker, Brittany N Dugger, Holly A Shill, Erika Driver-Dunckley, John N Caviness, Anthony Intorcia, Jessica Filon, Sarah Scott, Angelica Garcia, Brittany Hoffman, Christine M Belden, Kathryn J Davis, Marwan N Sabbagh
BACKGROUND: Clinical misdiagnosis, particularly at early disease stages, is a roadblock to finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide improved diagnostic accuracy. Previously, we reported, from both autopsy and needle biopsy, a high prevalence of submandibular gland synucleinopathy in Parkinson's disease (PD). Here, we report on an extension of these studies to subjects with dementia with Lewy bodies (DLB) and other Lewy body disorders in 228 autopsied subjects from the Arizona Study of Aging and Neurodegenerative Disorders...
2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/26754416/possible-pitfalls-in-the-diagnostic-of-progressive-multifocal-leukoencephalopathy
#14
Milanka Zivanovic, Lina Savšek, Mario Poljak, Mara Popovic
The most accurate diagnosis of clinically suspected progressive multifocal leukoencephalopathy (PML) is made by neuronavigated needle brain biopsy and microscopic examination of the specimen confirming typical morphological features of the disease and, additionally, using immunohistochemistry (IHC) for detection of early viral proteins of the etiologic agent - polyoma virus JC (JCV). Due to the small biopsy volume, this approach can sometimes fail to confirm the clinical diagnosis of PML, as demonstrated by the presented clinical case...
March 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/26677021/development-of-ct-guided-biopsy-sampling-for-time-dependent-postmortem-redistribution-investigations-in-blood-and-alternative-matrices-proof-of-concept-and-application-on-two-cases
#15
Sandra N Staeheli, Dominic Gascho, Juergen Fornaro, Patrick Laberke, Lars C Ebert, Rosa Maria Martinez, Michael J Thali, Thomas Kraemer, Andrea E Steuer
The postmortem redistribution (PMR) phenomenon complicates interpretation in forensic toxicology. Human data on time-dependent PMR are rare and only exist for blood so far. A new method for investigation of time-dependent PMR in blood as well as in alternative body fluids and tissues was developed and evaluated using automated biopsy sampling. At admission of the bodies, introducer needles were placed in liver, lung, kidney, muscle, spleen, adipose tissue, heart, femoral vein, and lumbar spine using a robotic arm guided by a computed tomography scanner (CT)...
February 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26662648/secondary-tumours-revealed-during-fine-needle-aspiration-of-the-thyroid-analysis-of-prevalence-and-characteristics-of-ultrasound-image
#16
Kamila Wysocka, Aneta Małyska, Damian Zadworny, Stanisław Sporny, Mariusz Klencki, Ewa Woźniak-Oseła, Włodzimierz Koptas, Bożena Popowicz, Dorota Słowińska-Klencka
INTRODUCTION: Metastases to the thyroid are revealed at autopsy with a frequency of 2-24%; however, clinically they appear less frequently, at 0.1-3%. The aim of the study was analysis of the frequency of revealing metastases to the thyroid (TM) and to the regional lymph nodes (NM) (neoplasms other than primary thyroid tumours) in preoperative diagnostics of the thyroid in patients with positive (C+) and negative (C-) history of cancer; analysis of ultrasound (US) images of metastases...
2015: Endokrynologia Polska
https://www.readbyqxmd.com/read/26646159/a-case-of-successful-detection-of-disseminated-gastrointestinal-stromal-tumors-by-ascites-smear-cytology-using-cell-block-preparation-with-dog1-immunostaining
#17
Shogo Tajima, Akihiro Kawabe, Kazunori Nagasaka, Katsutoshi Oda, Kei Kawana, Masashi Fukayama
Cytological features of gastrointestinal stromal tumors (GISTs) have been reported, especially regarding fine-needle aspiration cytology, including immunostaining for c-kit and DOG1. Meanwhile, cytological findings of GISTs on ascites cytology have rarely been reported, which may be owing to the rare appearance of GIST tumor cells in ascites. Herein, we present a 66-year-old woman who had disseminated GISTs in the abdomen. The GIST tumor cells appeared sparsely in the ascites smear cytology using ascites obtained at the time of autopsy...
February 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/26643281/a-new-non-craniotomy-model-of-subarachnoid-hemorrhage-in-the-pig-a-pilot-study
#18
Anders Backer-Grøndahl, Sigurd Lindal, Merethe Andberg Lorentzen, Petter Eldevik, Torgrim Vorren, Bente Kristiansen, Torgil Vangberg, Lars Marius Ytrebø
Subarachnoid hemorrhage (SAH) from rupture of an intracranial arterial aneurysm is a devastating disease affecting young people, with serious lifelong disability or death as a frequent outcome. Large animal models that exhibit all the cardinal clinical features of human SAH are highly warranted. In this pilot study we aimed to develop a non-craniotomy model of SAH in pigs suitable for acute intervention studies. Six Norwegian Landrace pigs received advanced invasive hemodynamic and intracranial pressure (ICP) monitoring...
October 2016: Laboratory Animals
https://www.readbyqxmd.com/read/26484322/occult-esophageal-squamous-cell-carcinoma-with-metastases-to-the-spine-and-central-nervous-system
#19
Ana Lídia Viaro, Carla Adriane Roballo, Pompeu Tomé Ribeiro de Campos, Carlos Osvaldo Teixeira, Maria Aparecida Barone Teixeira
Esophageal malignancy encompasses a group of diseases that are mostly represented by the squamous cell carcinoma and the adenocarcinoma. Quite frequently, these neoplasms present aggressive behavior; therefore, the diagnosis is often made when the condition is in advanced stages. Dysphagia is the typical clinical complaint, although it is present only when most of the lumen is obstructed. Therefore, quite often, the metastatic disease is first diagnosed, which contributes to the patient's poor survival expectancy...
January 2015: Autopsy & case reports
https://www.readbyqxmd.com/read/26329821/post-mortem-computed-tomography-and-core-needle-biopsy-in-comparison-to-autopsy-in-eleven-bernese-mountain-dogs-with-histiocytic-sarcoma
#20
Franziska C Hostettler, Dominique J Wiener, Monika M Welle, Horst Posthaus, Urs Geissbühler
BACKGROUND: Bernese mountain dogs are reported to have a shorter life expectancy than other breeds. A major reason for this has been assigned to a high tumour prevalence, especially of histiocytic sarcoma. The efforts made by the breeding clubs to improve the longevity with the help of genetic tests and breeding value estimations are impeded by insufficiently reliable diagnoses regarding the cause of death. The current standard for post mortem examination in animals is performance of an autopsy...
2015: BMC Veterinary Research
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