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needle autopsy

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https://www.readbyqxmd.com/read/28827844/post-mortem-computed-tomography-angiography-using-left-ventricle-cardiac-puncture-a-whole-body-angiographic-approach
#1
Yu Shao, Lei Wan, Jianhua Zhang, Zhengdong Li, Ningguo Liu, Ping Huang, Donghua Zou, Yijiu Chen
Post-mortem computed tomography (PMCT) and PMCT angiography (PMCTA) are rapidly becoming effective and practical methods in forensic medicine. In this article, the authors introduce a whole-body PMCTA approach involving left ventricle cardiac puncture. This procedure was performed in 9 males and 3 females. PMCT was performed first. Then a biopsy core needle was used for a percutaneous puncture into the left ventricle through the intercostal area under CT guidance. 1000 mL of contrast media (diatrizoate meglumine and normal saline [0...
2017: PloS One
https://www.readbyqxmd.com/read/28790241/-amyloidoma-adjacent-to-the-thoracic-vertebral-body-developed-into-systemic-amyloid-light-chain-amyloidosis
#2
Kyoko Tanaka, Hideto Goto, Shuhei Ikeda, Nami Masumoto, Katsuya Watanabe, Motofumi Tsubakihara
Amyloidoma is very rare case of amyloidosis, and seldom develop into systemic disease. We report a case of an 82-year-old man who was referred to our hospital because of an oppressive feeling in the upper chest. Chest computed tomography showed a tumor on thoracic vertebral body. Percutaneous needle biopsy showed pathological findings of AL amyloidosis. No obvious systemic finding was confirmed, and the tumor was diagnosed as amyloidoma. After a 1-year observation, heart amyloidosis was appeared, then 6 months later he died...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28763683/semiquantitative-screening-of-trace-combustion-derived-volatile-substances-in-the-blood-of-fire-victims-using-needlex-%C3%A2-headspace-gas-chromatography-mass-spectrometry
#3
Yasuhito Suzuki, Fujio Ishizawa, Katsuya Honda
BACKGROUND: Various autopsy findings are used for the diagnosis of burning death, including inhalation injury, soot in the respiratory tract, vital reaction, blood carboxyhemoglobin (COHb), and blood cyanide. However, not all findings are necessarily complete, and autopsy diagnosis can be difficult in cases where there are few findings. In this study, we analyzed combustion-derived volatile substances (CVSs) in post-mortem blood in fire-related cases, focusing on those that occur when buildings and furniture thermally decompose during a fire, and evaluated these as potential new autopsy findings...
September 2017: Forensic Science International
https://www.readbyqxmd.com/read/28719334/precisely-tracking-childhood-death
#4
Tamer H Farag, Jeffrey P Koplan, Robert F Breiman, Shabir A Madhi, Penny M Heaton, Trevor Mundel, Jaume Ordi, Quique Bassat, Clara Menendez, Scott F Dowell
Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28502713/an-autopsy-case-of-fatal-acute-peritonitis-complicated-by-illegal-acupuncture-therapy
#5
DongJa Kim, SangHan Lee
Acupuncture is an alternative medical therapy and widely practiced in Northeast Asia. Although it is known as a safe procedure, complications including infection, pneumothorax, hemorrhage, and cardiac tamponade have been reported. The authors present a rare case of fatal acute peritonitis due to penetration of acupuncture needles directly into the abdominal and pelvic cavity. The victim was a 55-year-old woman who had a recent history of chemo-radiotherapy due to breast cancer. She was collapsed three days after receiving acupuncture...
July 2017: Forensic Science International
https://www.readbyqxmd.com/read/28381111/spontaneous-spinal-plexiform-perineurioma-in-a-juvenile-chicken-gallus-domesticus
#6
Lara Cusack, Uriel Blas-Machado, Joerg Mayer
A 2-mo-old pet chicken ( Gallus domesticus) was presented because of lameness and a hind limb mass of 1 mo duration. Radiographs revealed a soft tissue mass extending from the mid-femur into the body wall. Cytology of a sample obtained from a fine-needle aspirate was unremarkable. The bird was prepared for surgical investigation of the mass but died acutely at the time of pre-medication. Autopsy revealed an extradural mesenchymal neoplasm that focally compressed the lumbar spinal cord, extended into and along the adjacent nerve structures, and displaced the kidneys, skeletal muscle, and body wall...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28381106/atypical-cytologic-presentation-of-a-histiocytic-sarcoma-in-a-cavalier-king-charles-spaniel-dog
#7
Lorelei L Clarke, Lisa S Kelly, Bridget Garner, Cathy A Brown
A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Additionally, there was a Chiari-like malformation of the skull with corresponding syringomyelia of the cranial spinal cord. Histologically, the neoplasm was comprised of a pleomorphic population of round cells with a high mitotic rate...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27880851/diagnostic-utility-of-pleural-fluid-cell-block-versus-pleural-biopsy-collected-by-flex-rigid-pleuroscopy-for-malignant-pleural-disease-a-single-center-retrospective-analysis
#8
Shion Miyoshi, Shinji Sasada, Takehiro Izumo, Yuji Matsumoto, Takaaki Tsuchida
BACKGROUND: Some trials recently demonstrated the benefit of targeted treatment for malignant disease; therefore, adequate tissues are needed to detect the targeted gene. Pleural biopsy using flex-rigid pleuroscopy and pleural effusion cell block analysis are both useful for diagnosis of malignancy and obtaining adequate samples. The purpose of our study was to compare the diagnostic utility between the two methods among patients with malignant pleural disease with effusion. METHODS: Data from patients who underwent flex-rigid pleuroscopy for diagnosis of pleural effusion suspicious for malignancy at the National Cancer Center Hospital, Japan between April 2011 and June 2014 were retrospectively reviewed...
2016: PloS One
https://www.readbyqxmd.com/read/27817167/post-mortem-computed-tomography-coaxial-cutting-needle-biopsy-to-facilitate-the-detection-of-bacterioplankton-using-pcr-probes-as-a-diagnostic-indicator-for-drowning
#9
Guy N Rutty, Christopher Johnson, Jasmin Amoroso, Claire Robinson, Carina J Bradley, Bruno Morgan
We report for the first time the use of coaxial cutting needle biopsy, guided by post-mortem computed tomography (PMCT), to sample internal body tissues for bacterioplankton PCR analysis to investigate drowning. This technical report describes the biopsy technique, the comparison of the needle biopsy and the invasive autopsy sampling results, as well as the PMCT and autopsy findings. By using this new biopsy sampling approach for bacterioplankton PCR, we have developed on previous papers describing the minimally invasive PMCT approach for the diagnosis of drowning...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27774746/prevalence-of-human-papillomavirus-epstein-barr-virus-and-cytomegalovirus-in-fine-needle-aspirates-from-lung-carcinoma-a-case-control-study-with-review-of-literature
#10
Parikshaa Gupta, Dipanjan Haldar, Jasmine Naru, Pranab Dey, Ashutosh Nath Aggarwal, Ranjana Walker Minz, Ritu Aggarwal
BACKGROUND: Oncogenic viruses have recently been allied with lung carcinoma, however, the causal association has not been established till date. The study was conducted to determine the prevalence of high-risk Human papillomavirus (HPV; subtypes 16, 18, 31, 33 and 45), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in lung carcinoma using polymerase chain reaction (PCR) on fine needle aspirates. METHODS: Fine needle aspirates of patients with lung carcinoma were included as cases...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27725467/nab-paclitaxel-gemcitabine-therapy-for-adenosquamous-carcinoma-of-the-pancreas-an-autopsy-case
#11
Kunio Kataoka, Hiroshi Matsubara, Fumihiro Urano, Shozo Okamura, Matsuyoshi Maeda
A male patient aged over 60 years presented with abdominal pain. A solid lesion measuring 7cm was detected in the pancreatic body and tail, along with periaortic lymphadenopathy. Endoscopic ultrasound-guided fine-needle aspiration suggested squamous cell carcinoma. Nab-paclitaxel+gemcitabine therapy was effective;however, tumor progression was noted after the completion of the fourth course, and the patient died from the primary cancer 7 months after the initial consultation. Autopsy led to a definitive diagnosis of adenosquamous carcinoma of the pancreas...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27591912/a-fatal-poisoning-case-by-intravenous-injection-of-bath-salts-containing-acetyl-fentanyl-and-4-methoxy-pv8
#12
Kosei Yonemitsu, Ako Sasao, Satoko Mishima, Yuki Ohtsu, Yoko Nishitani
A man in his 30's was found at home, not breathing. He was admitted to an emergency hospital and the doctor confirmed his death. He had a history of methamphetamine abuse spanning several years, and while fresh needle marks were visible on his arm, the only other autopsy findings indicated an acute death. A small plastic bag containing a pale brown white powder, and a small amount of liquid in a syringe were found at the scene. The police forensic laboratory detected acetyl fentanyl and 4-methoxy PV8 (4-methoxy PHPP) in both the powder and the liquid...
October 2016: Forensic Science International
https://www.readbyqxmd.com/read/27322966/use-of-cytology-as-an-auxiliary-diagnostic-tool-in-autopsies
#13
Luana Andrade, Vitória Lana Massarente, Stéphanie Corradini Tormin, Karina Braga Ribeiro, Geanete Pozzan, Mauro Ajaj Saieg
BACKGROUND: The use of minimally invasive procedures in autopsies such as image-guided fine-needle aspiration may facilitate family acceptance and, therefore, increase the number of postmortem examinations. The objective of the current study was to validate the use of cytology in a prospective set of conventional autopsies. METHODS: All lesions and organs sampled for histological examination were concomitantly evaluated by scrape cytology of exactly the same location...
November 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27246178/distribution-and-components-of-interstitial-inflammation-and-fibrosis-in-igg4-related-kidney-disease-analysis-of-autopsy-specimens
#14
COMPARATIVE STUDY
Satoshi Hara, Mitsuhiro Kawano, Ichiro Mizushima, Kenichi Harada, Takuma Takata, Takako Saeki, Yoshifumi Ubara, Yasuharu Sato, Michio Nagata
IgG4-related kidney disease (IgG4-RKD) occasionally progresses to chronic renal failure and is pathologically characterized by IgG4-positive lymphoplasmacyte-rich tubulointerstitial nephritis with storiform fibrosis (bird's-eye pattern fibrosis). Although radiology reveals a heterogeneous distribution of affected areas in this disease, their true distribution within the whole kidney is still unknown because of difficulty in estimating this from needle biopsy samples. Using 5 autopsy specimens, the present study histologically characterized the distribution and components of interstitial inflammation and fibrosis in IgG4-RKD...
September 2016: Human Pathology
https://www.readbyqxmd.com/read/27048880/spatial-and-temporal-homogeneity-of-driver-mutations-in-diffuse-intrinsic-pontine-glioma
#15
Hamid Nikbakht, Eshini Panditharatna, Leonie G Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L Ligon, Benjamin Ellezam, Wendy J Ingram, Caedyn Stinson, Andrew S Moore, Katherine E Warren, Jason Karamchandani, Roger J Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, here we analyse 134 specimens from various neuroanatomical structures of whole autopsy brains from nine DIPG patients. Evolutionary reconstruction indicates histone 3 (H3) K27M--including H3.2K27M--mutations potentially arise first and are invariably associated with specific, high-fidelity obligate partners throughout the tumour and its spread, from diagnosis to end-stage disease, suggesting mutual need for tumorigenesis...
April 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27039162/assessment-of-%C3%AE-synuclein-in-submandibular-glands-of-patients-with-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-a-case-control-study
#16
Dolores Vilas, Alex Iranzo, Eduardo Tolosa, Iban Aldecoa, Joan Berenguer, Isabel Vilaseca, Carles Martí, Mónica Serradell, Francisco Lomeña, Llucia Alós, Carles Gaig, Joan Santamaria, Ellen Gelpi
BACKGROUND: The histological feature of Parkinson's disease is the presence of intraneuronal aggregates of phosphorylated α-synuclein (αSyn). In patients with Parkinson's disease, deposits of αSyn are found in the autonomic nerve fibres of the submandibular gland. Since patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) can develop Parkinson's disease and other synucleinopathies, we investigated whether αSyn deposits could also be detected in their submandibular gland nerve fibres...
June 2016: Lancet Neurology
https://www.readbyqxmd.com/read/26913882/the-renal-history-of-fabry-disease
#17
Martina Gaggl, Sarah El-Hadi, Christof Aigner, Gere Sunder-Plassmann
In 1898 William Anderson and Johannes Fabry described the red-purple maculopapular skin lesions characteristic for Fabry disease and also mentioned the presence of proteinuria. Four decades later Maximiliaan Ruiter concluded that angiokeratoma corporis diffusum is the cutaneous manifestation of an inherited systemic internal disease. In 1947 autopsy findings of two cases who died from uraemia revealed sclerosis of glomeruli. At this time the presence of a thesaurismosis was also considered. The first renal needle biopsy in 1958 showed vacuolation and distension of the cells of the glomerular tufts and distal tubules suggestive of a storage disorder...
February 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26799362/peripheral-synucleinopathy-in-early-parkinson-s-disease-submandibular-gland-needle-biopsy-findings
#18
Charles H Adler, Brittany N Dugger, Joseph G Hentz, Michael L Hinni, David G Lott, Erika Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G Walker, Thomas G Beach
INTRODUCTION: Finding a peripheral tissue biopsy site to diagnose early PD would be of value for clinical care, biomarker validation, and as research enrollment criteria. Whereas autopsy and advanced PD studies suggest that the submandibular gland is an important biopsy site, there are no studies in early PD. The aim of this study was to determine whether needle biopsy of the submandibular gland reveals Lewy type alpha-synucleinopathy in early PD. METHODS: Twenty-five early PD (duration < 5 years) and 10 controls underwent transcutaneous needle core biopsies of the submandibular gland...
February 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/26766998/timely-diagnosis-of-pulmonary-artery-tumor-embolism-by-ultrasound-guided-transbronchial-needle-aspiration
#19
Seung Jun Lee, Jinwoo Lee, Su Jong Yu, Hyun Ju Lee, Kyung Ju Kim, Kyoung-Bun Lee, Young Sik Park
Pulmonary artery tumor embolism (PATE) is a rare disease without an established diagnostic method. In an autopsy series, however, the incidence of PATE was relatively high, between 3% and 26% in patients with a solid tumor. Here we report a case of a patient with a massive PATE from hepatocellular carcinoma diagnosed safely and promptly by endobronchial ultrasound-guided transbronchial needle aspiration.
March 2014: Thoracic Cancer
https://www.readbyqxmd.com/read/26756744/prevalence-of-submandibular-gland-synucleinopathy-in-parkinson-s-disease-dementia-with-lewy-bodies-and-other-lewy-body-disorders
#20
Thomas G Beach, Charles H Adler, Geidy Serrano, Lucia I Sue, D G Walker, Brittany N Dugger, Holly A Shill, Erika Driver-Dunckley, John N Caviness, Anthony Intorcia, Jessica Filon, Sarah Scott, Angelica Garcia, Brittany Hoffman, Christine M Belden, Kathryn J Davis, Marwan N Sabbagh
BACKGROUND: Clinical misdiagnosis, particularly at early disease stages, is a roadblock to finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide improved diagnostic accuracy. Previously, we reported, from both autopsy and needle biopsy, a high prevalence of submandibular gland synucleinopathy in Parkinson's disease (PD). Here, we report on an extension of these studies to subjects with dementia with Lewy bodies (DLB) and other Lewy body disorders in 228 autopsied subjects from the Arizona Study of Aging and Neurodegenerative Disorders...
2016: Journal of Parkinson's Disease
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