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https://www.readbyqxmd.com/read/29036874/development-of-a-device-to-reduce-the-risk-of-injury-in-handling-unstable-loads
#1
Mohamed Zaki Ramadan, Mohammed Alkahtani
BACKGROUND: Manual material handling (MMH) task is the most common cause of work-related musculoskeletal disorders (MSDs). Operators carrying unstable loads were recently shown to be at greater risk of back injury compared to workers carrying stable loads. OBJECTIVE: This study focused on developing a device to minimize trunk muscle activity and cardiovascular demand while handling a 19-liter bottle. METHOD: After evaluating several designs, one was selected to be developed, manufactured and tested through an experimental study...
October 10, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036785/wide-transcriptome-analysis-and-cellularity-of-bone-marrow-cd34-lin-cells-of-patients-with-chronic-phase-chronic-myeloid-leukemia-at-diagnosis-vs-12-months-of-first-line-nilotinib-treatment
#2
Alessandra Trojani, Ester Pungolino, Giuseppe Rossi, Mariella D'Adda, Milena Lodola, Barbara Di Camillo, Alessandra Perego, Mauro Turrini, Ester Orlandi, Lorenza Borin, Alessandra Iurlo, Simona Malato, Francesco Spina, Maria Luisa Latargia, Francesco Lanza, Salvatore Artale, Michela Anghilieri, Maria Cristina Carraro, Gabriella De Canal, Enrica Morra, Roberto Cairoli
BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined. OBJECTIVE: We undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin- cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29032267/long-term-follow-up-of-a-donor-versus-no-donor-comparison-in-multiple-myeloma-patients-at-first-relapse-after-failing-autologous-transplantation
#3
Francesca Patriarca, Benedetto Bruno, Hermann Einsele, Francesco Spina, Luisa Giaccone, Vittorio Montefusco, Miriam Isola, Chiara Nozzoli, Andrea Nozza, Fortunato Morabito, Paolo Corradini, Renato Fanin
We report the long-term clinical outcomes of a retrospective multicentre study that enrolled 169 multiple myeloma (MM) patients at first relapse after failing autologous stem cell transplantation (SCT). After HLA-typing at relapse, 79 patients with a suitable donor, 72 (91%) of whom eventually underwent salvage allogeneic SCT, were compared with 90 patients without a donor who were treated with multiple lines of salvage treatment with bortezomib and/or immune-modulating agents. At a median follow-up of 30 months (range 2-180) for all patients and 110 months (range 38-180) for surviving patients, 7-year progression free survival (PFS) was 18% in the donor group and 0% in the no-donor group (hazard ratio [HR] 2...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29018964/a-method-to-quantify-the-cone-of-economy
#4
Ram Haddas, Isador H Lieberman
STUDY DESIGN: A non-randomized, prospective, concurrent control cohort study. OBJECTIVE: The purpose of this study is to develop and evaluate a method to quantify the dimensions of the cone of economy (COE) and the energy expenditure associated with maintaining a balanced posture within the COE, scoliosis patients and compare them to matched non-scoliotic controls in a group of adult degenerative. Balance is defined as the ability of the human body to maintain its center of mass (COM) within the base of support with minimal postural sway...
October 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28992524/early-reduction-of-serum-tarc-levels-may-predict-for-success-of-abvd-as-frontline-treatment-in-patients-with-hodgkin-lymphoma
#5
A Guidetti, A Mazzocchi, R Miceli, E Paterno', F Taverna, F Spina, F Crippa, L Farina, P Corradini, A M Gianni, S Viviani
BACKGROUND: Many efforts have been made to predict prognosis of newly diagnosed Hodgkin Lymphoma (HL) patients. Objective of this study was to investigate the association between early reduction of Thymus and Activation-Regulated Chemokine after the first ABVD cycle (TARC-1) and prognosis of HL patients. METHODS: Serum samples of 116 HL patients were collected at baseline, after every ABVD cycle and during follow-up. The 99th centile of TARC distribution in a group of 156 independent healthy subjects (800pg/ml) was considered as cut-off for discriminating between abnormal and normal TARC values...
September 25, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28991732/feasibility-of-a-biomechanically-assistive-garment-to-reduce-low-back-loading-during-leaning-and-lifting
#6
Erik P Lamers, Aaron J Yang, Karl E Zelik
GOAL: The purpose of this study was: (i) to design and fabricate a biomechanically-assistive garment which was sufficiently lightweight and low-profile to be worn underneath, or as, clothing, and then (ii) to perform human subject testing to assess the ability of the garment to offload the low back muscles during leaning and lifting. METHODS: We designed a prototype garment which acts in parallel with the low back extensor muscles to reduce forces borne by the lumbar musculature...
October 9, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28991244/early-consolidation-with-high-dose-therapy-and-autologous-stem-cell-transplantation-is-a-feasible-and-effective-treatment-option-in-hiv-associated-non-hodgkin-lymphoma-at-high-risk
#7
A Re, G Gini, M Rupolo, A Levis, A Bandera, A M Liberati, P Tozzi, C Cattaneo, S Casari, C Skert, C Bocci, M Spina, B Allione, L Verga, M Michieli, C Almici, P F Leali, U Tirelli, G Rossi
No abstract text is available yet for this article.
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28988262/playing-the-clarinet-influence-of-body-posture-on-muscle-activity-and-sound-quality
#8
V Ae Baadjou, Mdf van Eijsden-Besseling, Jamcf Verbunt, R A de Bie, Rpj Geers, Rjem Smeets, Ham Seelen
Musculoskeletal complaints are highly prevalent in clarinetists and are related to high arm load while playing. It is hypothesized that postural exercise therapy may be used to adapt muscle activity patterns while playing and thus contribute to better sound quality. The goal of the present study was to investigate the relationship between body posture, muscle activity, and sound quality in clarinetists while playing the instrument in two different postures, their habitual sitting posture (control, CO) vs an experimental sitting posture (EXP) based on Mensendieck postural exercise therapy, method Samama...
September 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28987821/low-dose-lenalidomide-plus-cytarabine-in-very-elderly-unfit-acute-myeloid-leukemia-patients-final-result-of-a-phase-ii-study
#9
Giuseppe Visani, Felicetto Ferrara, Francesco Di Raimondo, Federica Loscocco, Fabio Fuligni, Stefania Paolini, Valentina Zammit, Eleonora Spina, Marco Rocchi, Axel Visani, Pier Paolo Piccaluga, Alessandro Isidori
Outcome for elderly patients with acute myeloid leukemia (AML) is extremely poor. Intensive induction chemotherapy is often unsuitable. Sixty-six newly diagnosed AML patients (median age: 76years), ineligible for standard therapy, were consecutively treated with low-dose lenalidomide (10mg/day orally, days 1-21) plus 10mg/m(2) low-dose cytarabine, subcutaneously, twice a day (days 1-15) every six weeks, up to 6 cycles. Complete remission (CR) rate was 36.3% according to intention-to-treat. Responding patients had a longer median overall survival than non-responders (517 vs...
September 25, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28987381/altered-gene-expression-profiles-in-the-lungs-of-benzo-a-pyrene-exposed-mice-in-the-presence-of-lipopolysaccharide-induced-pulmonary-inflammation
#10
Q Shi, R R Fijten, D Spina, Y Riffo Vasquez, V M Arlt, R W Godschalk, F J Van Schooten
Patients with inflammatory lung diseases are often additionally exposed to polycyclic aromatic hydrocarbons like B[a]P and B[a]P-induced alterations in gene expression in these patients may contribute to the development of lung cancer. Mice were intra-nasally treated with lipopolysaccharide (LPS, 20μg/mouse) to induce pulmonary inflammation and subsequently exposed to B[a]P (0.5mg/mouse) by intratracheal instillation. Gene expression changes were analyzed in mouse lungs by RNA microarrays. Analysis of genes that are known to be involved in the cellular response to B[a]P indicated that LPS significantly inhibited gene expression of various enzymes linked to B[a]P metabolism, which was confirmed by phenotypic analyses of enzyme activity...
October 4, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28980714/-18-f-flortaucipir-tau-pet-distinguishes-established-progressive-supranuclear-palsy-from-controls-and-parkinson-s-disease-a-multicenter-study
#11
Daniel R Schonhaut, Corey T McMillan, Salvatore Spina, Bradford C Dickerson, Andrew Siderowf, Michael D Devous, Richard Tsai, Joseph Winer, David S Russell, Irene Litvan, Erik D Roberson, William W Seeley, Lea T Grinberg, Joel H Kramer, Bruce L Miller, Peter Pressman, Ilya Nasrallah, Suzanne L Baker, Stephen N Gomperts, Keith A Johnson, Murray Grossman, William J Jagust, Adam L Boxer, Gil D Rabinovici
OBJECTIVE: (18) F-flortaucipir (formerly (18) F-AV1451 or (18) F-T807) binds to neurofibrillary tangles in Alzheimer's disease (AD), but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo (18) F-flortaucipir uptake in patients meeting clinical research criteria for PSP (N=33) to normal controls (N=46) and patients meeting criteria for Parkinson's disease (PD, N=26). METHODS: Participants underwent MRI and positron emission tomography for amyloid-β ((11) C-PiB or (18) F-florbetapir) and tau ((18) F-flortaucipir)...
October 5, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28962911/from-the-international-space-station-to-the-clinic-how-prolonged-unloading-may-disrupt-lumbar-spine-stability
#12
Jeannie F Bailey, Stephanie L Miller, Kristine Khieu, Conor W O'Neill, Robert M Healey, Dezba G Coughlin, Jojo V Sayson, Douglas G Chang, Alan R Hargens, Jeffrey C Lotz
Background context Prolonged microgravity exposure is associated with localized low back pain and an elevated risk of post-flight disc herniation. Though the mechanisms by which microgravity impairs the spine are unclear, they should be foundational for developing in-flight countermeasures for maintaining astronaut spine health. Because human spine anatomy has adapted to upright posture on Earth, observations of how spaceflight affects the spine should also provide new and potentially important information on spine biomechanics that benefit the general population...
September 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28961244/high-resolution-profiling-of-linear-b-cell-epitopes-from-mucin-associated-surface-proteins-masps-of-trypanosoma-cruzi-during-human-infections
#13
Ignacio M Durante, Pablo E La Spina, Santiago J Carmona, Fernán Agüero, Carlos A Buscaglia
BACKGROUND: The Trypanosoma cruzi genome bears a huge family of genes and pseudogenes coding for Mucin-Associated Surface Proteins (MASPs). MASP molecules display a 'mosaic' structure, with highly conserved flanking regions and a strikingly variable central and mature domain made up of different combinations of a large repertoire of short sequence motifs. MASP molecules are highly expressed in mammal-dwelling stages of T. cruzi and may be involved in parasite-host interactions and/or in diverting the immune response...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28959956/apoe4-markedly-exacerbates-tau-mediated-neurodegeneration-in-a-mouse-model-of-tauopathy
#14
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley, Oleg Butovsky, Ben A Barres, Steven M Paul, David M Holtzman
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. By generating P301S tau transgenic mice on either a human ApoE knock-in (KI) or ApoE knockout (KO) background, here we show that P301S/E4 mice have significantly higher tau levels in the brain and a greater extent of somatodendritic tau redistribution by three months of age compared with P301S/E2, P301S/E3, and P301S/EKO mice...
September 28, 2017: Nature
https://www.readbyqxmd.com/read/28958525/physico-chemical-properties-and-sensory-profile-of-durum-wheat-dittaino-pdo-protected-designation-of-origin-bread-and-quality-of-re-milled-semolina-used-for-its-production
#15
Virgilio Giannone, Mariagrazia Giarnetti, Alfio Spina, Aldo Todaro, Biagio Pecorino, Carmine Summo, Francesco Caponio, Vito Michele Paradiso, Antonella Pasqualone
To help future quality checks, we characterized the physico-chemical and sensory properties of Dittaino bread, a sourdough-based durum wheat bread recently awarded with Protected Designation of Origin mark, along with the quality features of re-milled semolina used for its production. Semolina was checked for Falling Number (533-644s), protein content (12.0-12.3g/100gd.m.), gluten content (9.7-10.5g/100gd.m.), yellow index (18.0-21.0), water absorption (59.3-62.3g/100g), farinograph dough stability (171-327s), softening index (46-66B...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28951832/advancing-functional-dysconnectivity-and-atrophy-in-progressive-supranuclear-palsy
#16
Jesse A Brown, Alice Y Hua, Andrew Trujllo, Suneth Attygalle, Richard J Binney, Salvatore Spina, Suzee E Lee, Joel H Kramer, Bruce L Miller, Howard J Rosen, Adam L Boxer, William W Seeley
Progressive supranuclear palsy syndrome (PSP-S) results from neurodegeneration within a network of brainstem, subcortical, frontal and parietal cortical brain regions. It is unclear how network dysfunction progresses and relates to longitudinal atrophy and clinical decline. In this study, we evaluated patients with PSP-S (n = 12) and healthy control subjects (n = 20) at baseline and 6 months later. Subjects underwent structural MRI and task-free functional MRI (tf-fMRI) scans and clinical evaluations at both time points...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28946538/effects-of-footrest-heights-on-muscle-fatigue-kinematics-and-kinetics-during-prolonged-standing-work
#17
Jae-Ik Son, Chung-Hwi Yi, Oh-Yun Kwon, Heon-Seock Cynn, One-Bin Lim, Yun-Jeong Baek, Ye-Ji Jung
BACKGROUND: Among the tools for relieving lower back pain, footrests are commonly recommended. Few studies have investigated the effects of footrest and the proper application of footrest height. OBJECTIVE: The purpose of this study was to compare the effects of the normalized footrest height on muscle fatigue, kinematics, kinetics, and pain intensity. METHODS: In total, 13 males who had a history of non-specific lower back pain during prolonged standing were recruited...
September 8, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28943402/effect-of-modified-bridge-exercise-on-trunk-muscle-activity-in-healthy-adults-a-cross-sectional-study
#18
Jeong-Oh Yoon, Min-Hyeok Kang, Jun-Seok Kim, Jae-Seop Oh
DESIGN: This is a cross-sectional study. SETTING: University research laboratory. PARTICIPANTS: Fifteen healthy adults (mean age: 27.47 years) volunteered for this study. INTERVENTION: The individuals performed standard bridge exercise and modified bridge exercises with right leg-lift (single-leg-lift bridge exercise, single-leg-lift bridge exercise on an unstable surface, and single-leg-lift hip abduction bridge exercise)...
September 9, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28940753/prevalence-virulence-factors-and-antifungal-susceptibility-of-candida-spp-isolated-from-bloodstream-infections-in-a-tertiary-care-hospital-in-brazil
#19
Heliara Maria Spina Canela, Bárbara Cardoso, Lucia Helena Vitali, Harnoldo Colares Coelho, Roberto Martinez, Márcia Eliana da Silva Ferreira
Candida spp. are responsible for 80% of all systemic fungal infections and are associated with high mortality rates. This study characterised 79 bloodstream isolates of C. albicans, C. glabrata, C. orthopsilosis, C. parapsilosis and C. tropicalis from patients in a Brazilian hospital. The susceptibility to amphotericin B, caspofungin, fluconazole and voriconazole was determined; virulence factor production was assessed based on haemolysin, phospholipase and proteinase activities, and the patients' clinical characteristics were analysed...
September 22, 2017: Mycoses
https://www.readbyqxmd.com/read/28935878/old-yellow-enzyme-homologues-in-mucor-circinelloides-expression-profile-and-biotransformation
#20
Alice Romagnolo, Federica Spina, Anna Poli, Sara Risso, Bianca Serito, Michele Crotti, Daniela Monti, Elisabetta Brenna, Luisa Lanfranco, Giovanna Cristina Varese
The reduction of C=C double bond, a key reaction in organic synthesis, is mostly achieved by traditional chemical methods. Therefore, the search for enzymes capable of performing this reaction is rapidly increasing. Old Yellow Enzymes (OYEs) are flavin-dependent oxidoreductases, initially isolated from Saccharomyces pastorianus. In this study, the presence and activation of putative OYE enzymes was investigated in the filamentous fungus Mucor circinelloides, which was previously found to mediate C=C reduction...
September 21, 2017: Scientific Reports
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