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https://www.readbyqxmd.com/read/28433778/novel-lipid-mimetic-prodrugs-delivering-active-compounds-to-adipose-tissue
#1
Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
Obesity and associated pathologies are a dramatically growing problem. New therapies to prevent and/or cure them are strongly needed. Adipose tissue is a logical target for pharmacological intervention, since it is now recognized to exert an important endocrine function, secreting a variety of adipokines affecting, for example, adiposity and insulin resistance. This proof of principle work focuses on the development of novel lipid-mimetic prodrugs reaching fat deposits by the same lymphatic absorption route followed by dietary triglycerides...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28432214/a-microrna-mrna-expression-network-during-oral-siphon-regeneration-in-ciona
#2
Elijah J Spina, Elmer Guzman, Hongjun Zhou, Kenneth S Kosik, William C Smith
Here we present a parallel study of mRNA and microRNA expression during oral siphon (OS) regeneration in Ciona robusta, and the derived network of their interactions. In the process of identifying 248 mRNAs and 15 microRNAs as differentially expressed (DE), we also identified 57 novel microRNAs, several of which are among the most highly DE. Analysis of functional categories identified enriched transcripts related to stress responses and apoptosis at the wound healing stage, signaling pathways including Wnt and TGF-β during early regrowth, and negative regulation of extracellular proteases in late stage regeneration...
April 21, 2017: Development
https://www.readbyqxmd.com/read/28420353/the-influence-of-fatigue-and-chronic-low-back-pain-on-muscle-recruitment-patterns-following-an-unexpected-external-perturbation
#3
Júlia Jubany, Lieven Danneels, Rosa Angulo-Barroso
BACKGROUND: Chronic low back pain (CLBP) has been associated with altered trunk muscle responses as well as increased muscle fatigability. CLBP patients and fatigued healthy subjects could experience similar neuromuscular strategies to attempt to protect the spine. The current study examined muscle activation differences between healthy and CLBP subjects following a perturbation. In addition, the possible role of muscle fatigue was evaluated by investigating the healthy control subjects in a non-fatigued and a fatigued condition...
April 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28411737/neck-posture-during-lifting-and-its-effect-on-trunk-muscle-activation-and-lumbar-spine-posture
#4
Thomas M Hlavenka, Vanessa F K Christner, Diane E Gregory
Neck and head posture have been found to have a significant influence on the posture of the lower spine region during lifting and both an extended/upward gaze and a flexed/downward gaze have been hypothesized to lead to increased pain and/or overuse of the neck musculature. As a result, strength training recommendations have turned to the use of a retracted neck posture as being the safer posture to assume during lifting. This study examined trunk and neck muscle activity and lumbar spine posture in seven participants while performing moderate load lifts using a retracted neck posture (chin drawn in posteriorly; recently gaining popularity among coaches, trainers, and physical therapists to reduce neck pain during lifting, and freestyle neck posture (no instructions given)...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28410663/frontotemporal-dementia
#5
REVIEW
Nicholas T Olney, Salvatore Spina, Bruce L Miller
Frontotemporal dementia (FTD) is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic entities. Presently, the term FTD encompasses clinical disorders that include changes in behavior, language, executive control, and often motor symptoms. The core FTD spectrum disorders include behavioral variant FTD, nonfluent/agrammatic variant primary progressive aphasia, and semantic variant PPA. Related FTD disorders include frontotemporal dementia with motor neuron disease, progressive supranuclear palsy syndrome, and corticobasal syndrome...
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28406557/determinants-of-iliac-blade-orientation-in-anthropoid-primates
#6
Emily R Middleton, Zachariah J Winkler, Ashley S Hammond, J Michael Plavcan, Carol V Ward
Orientation of the iliac blades is a key feature that appears to distinguish extant apes from monkeys. Iliac morphology is hypothesized to reflect variation in thoracic shape that, in turn, reflects adaptations for shoulder and forearm function in anthropoids. Iliac orientation is traditionally measured relative to the acetabulum, whereas functional explanations pertain to its orientation relative to the cardinal anatomical planes. We investigated iliac orientation relative to a median plane using digital models of hipbones registered to landmark data from articulated pelves...
May 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28401494/a-comparative-optical-coherence-tomography-study-of-spinocerebellar-ataxia-types-3-and-10
#7
Fernando Spina Tensini, Mario T Sato, Naoye Shiokawa, Tetsuo Ashizawa, Hélio A G Teive
SCA3 presents with a CAG expansion at 14q24.3-q32 while SCA10 shows an ATTCT expansion at 22q13-qter. SCA10 seems to be less aggressive than SCA3. For an in vivo, noninvasive approach of the correlation between central nervous system and clinical evolution, we can use optic coherence tomography (OCT) to measure retinal nerve fiber (RNFL) and ganglion cell layer (GCL) thickness. To describe OCT findings in SCA10, correlate it with expansion size and disease severity and compare with those of SCA3. We analyzed ten individuals with SCA3 and nine with SCA10 recruited from the neurology service of Hospital de Clínicas of Paraná-Brazil...
April 11, 2017: Cerebellum
https://www.readbyqxmd.com/read/28399877/overground-vs-treadmill-based-robotic-gait-training-to-improve-seated-balance-in-people-with-motor-complete-spinal-cord-injury-a-case-report
#8
Amanda E Chisholm, Raed A Alamro, Alison M M Williams, Tania Lam
BACKGROUND: Robotic overground gait training devices, such as the Ekso, require users to actively participate in triggering steps through weight-shifting movements. It remains unknown how much the trunk muscles are activated during these movements, and if it is possible to transfer training effects to seated balance control. This study was conducted to compare the activity of postural control muscles of the trunk during overground (Ekso) vs. treadmill-based (Lokomat) robotic gait training, and evaluate changes in seated balance control in people with high-thoracic motor-complete spinal cord injury (SCI)...
April 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28394829/electromyographical-comparison-of-muscle-activation-patterns-across-three-commonly-performed-kettlebell-exercises
#9
Brian C Lyons, Jerry J Mayo, W Steve Tucker, Ben Wax, Russell C Hendrix
The purpose of this study was to compare the muscle activation patterns of three different kettlebell (KB) exercises using electromyography (EMG). Fourteen resistance-trained subjects completed a one-arm swing (Swing), one-arm swing style snatch (Snatch), and a one-arm clean (Clean) using a self-selected 8-10 RM load for each exercise. Trial sessions consisted of subjects performing 5 repetitions of each kettlebell exercise. Mean EMG was used to assess the muscle activation of the biceps brachii (BB), anterior deltoid (AD), posterior deltoid (PD), erector spinae (ES), vastus lateralis (VL), biceps femoris (BF), contralateral external oblique (EO), and gluteus maximus (GM) during each lift using surface electrodes...
December 20, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28391895/identification-of-a-novel-lmf1-nonsense-mutation-responsible-for-severe-hypertriglyceridemia-by-targeted-next-generation-sequencing
#10
Angelo B Cefalù, Rossella Spina, Davide Noto, Valeria Ingrassia, Vincenza Valenti, Antonina Giammanco, Francesca Fayer, Gabriella Misiano, Gianfranco Cocorullo, Chiara Scrimali, Ornella Palesano, Grazia I Altieri, Antonina Ganci, Carlo M Barbagallo, Maurizio R Averna
BACKGROUND: Severe hypertriglyceridemia (HTG) may result from mutations in genes affecting the intravascular lipolysis of triglyceride (TG)-rich lipoproteins. OBJECTIVE: The aim of this study was to develop a targeted next-generation sequencing panel for the molecular diagnosis of disorders characterized by severe HTG. METHODS: We developed a targeted customized panel for next-generation sequencing Ion Torrent Personal Genome Machine to capture the coding exons and intron/exon boundaries of 18 genes affecting the main pathways of TG synthesis and metabolism...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28385661/intact-cell-maldi-tof-mass-spectrometry-on-single-bovine-oocyte-and-follicular-cells-combined-with-top-down-proteomics-a-novel-approach-to-characterise-markers-of-oocyte-maturation
#11
Valérie Labas, Ana-Paula Teixeira-Gomes, Laura Bouguereau, Audrey Gargaros, Lucie Spina, Aurélie Marestaing, Svetlana Uzbekova
Intact cell MALDI-TOF mass spectrometry (ICM-MS) was adapted to bovine follicular cells from individual ovarian follicles to obtain the protein/peptide signatures (<17kDa) of single oocytes, cumulus cells (CC) and granulosa cells (GC), which shared a total of 439 peaks. By comparing the ICM-MS profiles of single oocytes with CC before and after in vitro maturation (IVM), 71 different peaks were characterised, and their relative abundance was found to vary depending on the stage of oocyte meiotic maturation...
April 3, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28379709/fe-doping-induced-magnetism-in-nano-hydroxyapatites
#12
Vincenzo Iannotti, Alessio Adamiano, Giovanni Ausanio, Luciano Lanotte, Giuliana Aquilanti, John Michael David Coey, Marco Lantieri, Gabriele Spina, Maria Fittipaldi, George Margaris, Kalliopi Trohidou, Simone Sprio, Monica Montesi, Silvia Panseri, Monica Sandri, Michele Iafisco, Anna Tampieri
Doping of biocompatible nanomaterials with magnetic phases is currently one of the most promising strategies for the development of advanced magnetic biomaterials. However, especially in the case of iron-doped magnetic hydroxyapatites, it is not clear if the magnetic features come merely from the magnetic phases/ions used as dopants or from complex mechanisms involving interactions at the nanoscale. Here, we report an extensive chemical-physical and magnetic investigation of three hydroxyapatite nanocrystals doped with different iron species and containing small or no amounts of maghemite as a secondary phase...
April 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28377244/trigeminal-neuralgia-toward-a-multimodal-approach
#13
REVIEW
Alfio Spina, Pietro Mortini, Federica Alemanno, Elise Houdayer, Sandro Iannaccone
OBJECTIVES: Trigeminal neuralgia (TN) is the most common cranial neuralgia in adults, with a slight prevalence in women. Antiepileptic drugs represent the mainstay of the medical treatment, whereas microvascular decompression is the best option in case of neurovascular conflict. Although these treatments showed good rate of efficacy, they can be contraindicated in some patients and more than 50% of patients undergoing these treatments will present recurrence of pain in the following months...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28372312/the-recovery-of-damaged-paraspinal-muscles-by-posterior-surgical-treatment-for-patients-with-lumbar-degenerative-diseases-and-its-clinical-consequence
#14
Jae-Ryong Cha, Yong-Chan Kim, Wan-Keun Yoon, Won-Gyu Lee, Tae-Hwan Kim, Jae-Keun Oh, Seok-Woo Kim, Suk Hoon Ohn, Ji Hao Cui
BACKGROUND: Posterior lumbar surgery can lead to damage on paraspinal muscles. OBJECTIVE: Our study aimed to examine the recovery in the denervated paraspinal muscles by posterior lumbar surgery and to determine that of improvement in the lower back pain (LBP). METHODS: Depending on surgical treatments, the patients were divided into two groups: The group I (interspinous implantation with decompression) and II (posterior lumbar interbody fusion with decompression)...
March 24, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28369283/the-hiv-continuum-of-care-in-european-union-countries-in-2013-data-and-challenges
#15
Annabelle Gourlay, Teymur Noori, Anastasia Pharris, Maria Axelsson, Dominique Costagliola, Susan Cowan, Sara Croxford, Antonella d'Arminio Monforte, Julia Del Amo, Valerie Delpech, Asunción Díaz, Enrico Girardi, Barbara Gunsenheimer-Bartmeyer, Victoria Hernando, Sophie Jose, Gisela Leierer, Georgios Nikolopoulos, Niels Obel, Eline Op de Coul, Dimitra Paraskeva, Peter Reiss, Caroline Sabin, André Sasse, Daniela Schmid, Anders Sonnerborg, Alexander Spina, Barbara Suligoi, Virginie Supervie, Giota Touloumi, Dominique Van Beckhoven, Ard van Sighem, Georgia Vourli, Robert Zangerle, Kholoud Porter
Background: UNAIDS has set a 90-90-90 target to curb the HIV epidemic by 2020, but methods used to assess whether countries have reached this target are not standardised, hindering comparisons. Methods: Through a collaboration formed by the European Centre for Disease Prevention and Control (ECDC) with European HIV cohorts and surveillance agencies, we constructed a standardised, four-stage continuum of HIV care for 11 European Union (EU) countries for 2013. Stages were defined as: 1) number of people living with HIV (PLHIV) in the country by end of 2013; 2) proportion of stage 1 ever diagnosed; 3) proportion of stage 2 ever initiated ART; and 4) proportion of stage 3 who became virally-suppressed (≤200 copies/mL)...
March 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28368509/in-higher-risk-myelodysplastic-syndromes-and-low-blast-count-acute-myeloid-leukemia-results-of-the-bmt-aza-prospective-study
#16
M T Voso, G Leone, A Piciocchi, L Fianchi, S Santarone, A Candoni, M Criscuolo, A Masciulli, E Cerqui, A Molteni, C Finelli, M Parma, A Poloni, A M Carella, F Spina, A Cortelezzi, F Salvi, E P Alessandrino, A Rambaldi, S Sica
Background: Allogeneic stem cell transplantation (HSCT) is the only curative treatment in myelodysplastic syndromes (MDS). Azacitidine (AZA) is increasingly used prior to HSCT, however in Europe it is only approved for patients who are not eligible for HSCT. Patients and Methods: We conducted a phase II multicenter study to prospectively evaluate the feasibility of HSCT after treatment with AZA in 70 patients with a myelodysplastic syndrome (MDS), 19 with acute myeloid leukemia (AML), and 8 with chronic myelomonocytic leukemia (CMML)...
March 29, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28368291/glucose-induced-%C3%AE-cell-production-of-il-1%C3%AE-contributes-to-glucotoxicity-in-human-pancreatic-islets
#17
Kathrin Maedler, Pavel Sergeev, Frédéric Ris, José Oberholzer, Helen I Joller-Jemelka, Giatgen A Spinas, Nurit Kaiser, Philippe A Halban, Marc Y Donath
No abstract text is available yet for this article.
April 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28364860/regulatory-effects-of-estetrol-on-the-endothelial-plasminogen-pathway-and-endothelial-cell-migration
#18
Maria Magdalena Montt-Guevara, Giulia Palla, Stefania Spina, Guja Bernacchi, Elena Cecchi, Adrian Esteban Campelo, Jorge Eduardo Shortrede, Alessio Canu, Tommaso Simoncini
BACKGROUND: Estetrol (E4) is a natural estrogen produced solely during human pregnancy. E4 is suitable for clinical use since it acts as a selective estrogen receptor modulator. In clinical trials E4 has been seen to have little or no effect on coagulation. Hence, it is interesting to investigate whether E4 alters endothelial-dependent fibrinolysis. OBJECTIVES: We studied the effects of E4 on the fibrinolytic system and whether this could influence the ability of endothelial cells to migrate...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28362047/the-vietnamese-pig-as-a-translational-animal-model-to-evaluate-tissue-engineered-heart-valves-promising-early-experience
#19
Michele Gallo, Helen Poser, Tomaso Bottio, Antonella Bonetti, Paolo Franci, Filippo Naso, Edward Buratto, Fabio Zanella, Giovanni Perona, Carlo Dal Lin, Roberto Bianco, Michele Spina, Roberto Busetto, Maurizio Marchini, Fulvia Ortolani, Laura Iop, Gino Gerosa
Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model...
March 27, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28361603/repeatability-of-emg-normalization-of-the-neck-and-shoulder-muscles-in-symptomatic-office-workers
#20
Montakarn Chaikumarn, Nuttika Nakphet, Prawit Janwantanakul
PURPOSE: The purpose of the study was to examine the repeatability of Electromyography (EMG) normalisation in office workers with neck and shoulder symptoms. METHODS: Fifteen female office workers with neck/shoulder symptoms were recruited to participate in two separate days of testing. Maximum voluntary isometric contraction (MVIC) was used for the normalisation of EMG data on the following muscles: cervical erector spinae (CES), upper trapezius (UT), lower trapezius (LT), and anterior deltoid (AD)...
March 31, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
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