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https://www.readbyqxmd.com/read/29454149/study-of-manganese-binding-to-the-ferroxidase-centre-of-human-h-type-ferritin
#1
Matteo Ardini, Barry D Howes, Annarita Fiorillo, Elisabetta Falvo, Silvia Sottini, Donella Rovai, Marco Lantieri, Andrea Ilari, Dante Gatteschi, Gabriele Spina, Emilia Chiancone, Simonetta Stefanini, Maria Fittipaldi
Ferritins are ubiquitous and conserved proteins endowed with enzymatic ferroxidase activity, that oxidize Fe(II) ions at the dimetal ferroxidase centre to form a mineralized Fe(III) oxide core deposited within the apo-protein shell. Herein, the in vitro formation of a heterodimetal cofactor constituted by Fe and Mn ions has been investigated in human H ferritin (hHFt). Namely, Mn and Fe binding at the hHFt ferroxidase centre and its effects on Fe(II) oxidation have been investigated by UV-Vis ferroxidation kinetics, fluorimetric titrations, multifrequency EPR, and preliminary Mössbauer spectroscopy...
February 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29449731/mixed-malignant-mullerian-tumor-with-neuroendocrine-features-in-an-irradiated-uterus-for-cervical-carcinoma-a-unique-association-a-morphological-immunohistochemisty-and-ultrastructural-study
#2
V G Vellone, B Spina, F Grillo, P Calamaro, F Sarocchi, P Sala, S Ferrero, E Fulcheri
Chemo-radiation represents an effective therapy for carcinoma of the uterine cervix. The endometrium may however receive a consistent dose of mutagenic radiations and patients may have an increased risk of secondary malignancies. Endometrial mixed malignant mullerian tumor (MMMT) is a rare, highly aggressive disease, and neuroendocrine features are even rarer. A 68 years old woman underwent radio-chemotherapy for a squamous cell carcinoma of the cervix. Follow up was uneventful until, eight years after radio-chemotherapy, imaging exams detected a diffuse enlargement of the uterine body...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449275/circulating-tumor-dna-reveals-genetics-clonal-evolution-and-residual-disease-in-classical-hodgkin-lymphoma
#3
Valeria Spina, Alessio Bruscaggin, Annarosa Cuccaro, Maurizio Martini, Martina Di Trani, Gabriela Forestieri, Martina Manzoni, Adalgisa Condoluci, Alberto Arribas, Lodovico Terzi-Di-Bergamo, Silvia Laura Locatelli, Elisa Cupelli, Luca Ceriani, Alden A Moccia, Anastasios Stathis, Luca Nassi, Clara Deambrogi, Fary Diop, Francesca Guidetti, Alessandra Cocomazzi, Salvatore Annunziata, Vittoria Rufini, Alessandro Giordano, Antonino Neri, Renzo Boldorini, Bernhard Gerber, Francesco Bertoni, Michele Ghielmini, Georg Stüssi, Armando Santoro, Franco Cavalli, Emanuele Zucca, Luigi Maria Larocca, Gianluca Gaidano, Stefan Hohaus, Carmelo Carlo-Stella, Davide Rossi
The rarity of neoplastic cells in the biopsy imposes major technical hurdles that have so far limited genomic studies in classical Hodgkin lymphoma (cHL). By using a highly sensitive and robust deep-next-generation-sequencing approach for circulating tumor DNA (ctDNA), here we aimed at tracking the genetics of cHL in different clinical phases, and its modifications upon treatment. The analysis was based on specimens collected from 80 newly diagnosed and 32 refractory cHL patients, including longitudinal samples collected under ABVD chemotherapy and longitudinal samples from relapsing patients treated with chemotherapy and immunotherapy...
February 15, 2018: Blood
https://www.readbyqxmd.com/read/29446694/experimental-measurement-of-forces-during-percutaneous-dilatational-tracheostomy
#4
Silvia Pancani, Antonio Virga, Rosario Spina, Adriano Peris, Andrea Corvi
The measurement of mechanical effects associated with the dilatation phase of a percutaneous dilatational tracheostomy is of primary importance to identify the causes of major complications associated with this procedure, such as tracheal cartilage subluxation or fracture and bleeding. Such information can be very useful also for the design of better instruments and procedures. The aim of this study was to present a methodology to evaluate mechanical effects of the dilatation phase of a percutaneous dilatational tracheostomy on the tracheal rings and adjacent anatomical structures...
February 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29446170/magnetic-resonance-elastography-of-the-lumbar-back-muscles-a-preliminary-study
#5
Maud Creze, Soubeyrand Marc, Jin Long Yue, Olivier Gagey, Xavier Maître, Bellin Marie-France
INTRODUCTION: Back pain is associated with increased lumbar paraspinal muscle (LPM) stiffness identified by manual palpation and strain elastography. Recently, magnetic resonance elastography (MRE) has allowed the stiffness of muscle to be characterized noninvasively in vivo, providing quantitative 3D stiffness maps (elastograms). The aim of this study was to characterize the stiffness (shear modulus, SM) of the LPM (multifidus and erector spinae) using MRE. MATERIALS AND METHODS: MRE of the lumbar region was performed on seven adults in supine position...
February 15, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29444776/association-between-spectral-characteristics-of-paraspinal-muscles-and-functional-disability-in-patients-with-low-back-pain-a-cohort-study
#6
Shin-Yi Chiou, Ermis Koutsos, Pantelis Georgiou, Paul H Strutton
OBJECTIVES: Characteristics of muscle activity, represented by surface electromyography (EMG), have revealed differences between patients with low back pain (LBP) and healthy adults; how they relate to functional and clinical parameters remains unclear. The purpose of the current study was to examine the correlation between frequency characteristics of EMG (analysed using continuous wavelet transform (CWT) analysis) and patients' self-rated score of disability. DESIGN AND SETTING: This is a case-control study with 15 patients with mechanical LBP without radicular symptoms...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29444538/-effects-of-judo-specific-resistance-training-on-kinetic-and-electromyographic-parameters-of-pulling-exercises-in-judo-athletes
#7
Norman Helm, Olaf Prieske, Thomas Muehlbauer, Tom Krüger, Urs Granacher
BACKGROUND: In judo, rapid force production during pulling movements is an important component of athletic performance, which is why this capacity needs to be specifically exercised in judo. This study aimed at examining the effects of a judo-specific resistance training program using a judo ergometer system (PTJ) versus a traditional resistance training regime using a partner (PTP) on kinetics and muscle activity of judo-specific pulling exercises. METHOD: Twenty-four male judo athletes (age: 22 ± 4 years, training experience: 15 ± 3 years) were randomly assigned to two groups...
February 14, 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29434457/role-and-significance-of-trunk-and-upper-extremity-muscles-in-walker-assisted-paraplegic-gait-a-case-study
#8
Mina Baniasad, Farzam Farahmand, Mokhtar Arazpour, Hassan Zohoor
Background and Purpose: Understanding the role and significance of trunk and upper extremity muscles in paraplegic gait can help in designing more effective assistive devices for these patients and also provides valuable information for improving muscle strengthening programs. Methods: In a patient with a spinal cord injury (SCI) who could walk independently (rating scale of ambulatory capacity, 9) with the aid of bilateral ankle-foot orthosis and a walker, the kinematics, kinetics and electromyographic (EMG) activities of 16 muscles from the trunk and upper and lower extremities were recorded during gait...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29430263/traumatic-dental-injuries-resulting-from-sports-activities-immediate-treatment-and-five-years-follow-up-an-observational-study
#9
Enrico Spinas, Antonello Mameli, Luca Giannetti
Background: Traumatic dental injuries (TDIs) represent 18-30% of all oral pathologies and a considerable number of these are sports related. It is very important to treat sports-related injuries and prevent complications. However, very few studies investigate the most expedient therapeutic strategies for the treatment of dental trauma correlated to sports. Objective: The aim of this work was to focus on the average recovery time for different lesions, to assess adequate times for each athlete, to identify any association with complications and to investigate whether or not the use of mouth-guards interfered with a full recovery to normal health...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29422869/the-effect-of-bed-rest-and-hypoxic-environment-on-postural-balance-and-trunk-automatic-re-actions-in-young-healthy-males
#10
Nejc Šarabon, Igor B Mekjavić, Ola Eiken, Jan Babič
Prolonged inactivity, such as bed rest induces several detrimental changes within a short timeframe. Impaired postural balance and responses of trunk muscles to (un)expected perturbations were both shown to be impaired after bed rest. Certain populations (e.g., astronauts) are exposed to hypoxic environment in addition to inactivity, similar to bed rest. While the isolated negative effects of hypoxia on postural balance have been observed before, no study to date has examined the combined effects of hypoxia and bed rest on postural balance or trunk muscle responses...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29416155/erector-spinae-plane-block-as-an-alternative-to-epidural-analgesia-for-post-operative-analgesia-following-video-assisted-thoracoscopic-surgery-a-case-study-and-a-literature-review-on-the-spread-of-local-anaesthetic-in-the-erector-spinae-plane
#11
Sanjib Das Adhikary, Ashlee Pruett, Mauricio Forero, Venkatesan Thiruvenkatarajan
Post-operative pain after minimally invasive video-assisted thoracoscopic surgery (VATS) in adults is commonly managed with oral and parenteral opioids and invasive regional techniques such as thoracic epidural blockade. Emerging research has shown that the novel erector spinae plane (ESP) block, can be employed as a simple and safe alternative analgesic technique for acute post-surgical, post-traumatic and chronic neuropathic thoracic pain in adults. We illustrate this by presenting a paediatric case of VATS, in which an ESP block provided better analgesia, due to greater dermatomal coverage, as well as reduced side-effects when compared with a thoracic epidural that had previously been employed on the same patient for a similar procedure on the opposite side...
January 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29413453/reliability-of-ultrasound-shear-wave-elastography-in-assessing-low-back-musculature-elasticity-in-asymptomatic-individuals
#12
Shane Koppenhaver, Joshua Kniss, Daniel Lilley, Michael Oates, Cesar Fernández-de-Las-Peñas, Ruth Maher, Theodore Croy, Minoru Shinohara
Patients with low back pain commonly exhibit impaired morphology and function of spinal musculature that may be quantifiable using shear-wave elastography (SWE). The purpose of this study was to assess the intra-rater and test-retest reliability of SWE elasticity measures of the lumbar erector spinae and multifidus muscles during rest and differing levels of contraction in asymptomatic individuals. This single-group repeated-measures design involved a baseline measurement session and a follow-up session 3 days later...
February 2, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29413451/muscle-activity-and-kinetics-of-lower-limbs-during-walking-in-pronated-feet-individuals-with-and-without-low-back-pain
#13
Nader Farahpour, AmirAli Jafarnezhadgero, Paul Allard, Mahdi Majlesi
The objectives of this study were to investigate whether excessive feet pronation alters the joints' kinematics, kinetics and the activity of involved muscles during gait in low back pain patients. METHODS: The lower limb joints' motion, moment and power, as well as the activity of involved muscles during walking were measured in a control group, and two experimental groups including a group with excessive feet pronation only, and another group of low back pain patients with excessive feet pronation...
January 30, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29413449/trunk-movement-compensations-and-corresponding-core-muscle-demand-during-step-ambulation-in-people-with-unilateral-transtibial-amputation
#14
Brecca M M Gaffney, Cory L Christiansen, Amanda M Murray, Bradley S Davidson
The objective of this investigation was to identify demands from core muscles that corresponded with trunk movement compensations during bilateral step ambulation in people with unilateral transtibial amputation (TTA). Trunk rotational angular momentum (RAM) was measured using motion capture and bilateral surface EMG was measured from four bilateral core muscles during step ascent and descent tasks in people with TTA and healthy controls. During step ascent, the TTA group generated larger mediolateral (P = 0...
January 24, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29409626/assessment-of-an-active-industrial-exoskeleton-to-aid-dynamic-lifting-and-lowering-manual-handling-tasks
#15
Kirsten Huysamen, Michiel de Looze, Tim Bosch, Jesus Ortiz, Stefano Toxiri, Leonard W O'Sullivan
The aim of this study was to evaluate the effect of an industrial exoskeleton on muscle activity, perceived musculoskeletal effort, measured and perceived contact pressure at the trunk, thighs and shoulders, and subjective usability for simple sagittal plane lifting and lowering conditions. Twelve male participants lifted and lowered a box of 7.5 kg and 15 kg, respectively, from mid-shin height to waist height, five times, both with and without the exoskeleton. The device significantly reduced muscle activity of the Erector Spinae (12%-15%) and Biceps Femoris (5%)...
April 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29396458/m%C3%A3-ssbauer-spectroscopy-of-a-monolayer-of-single-molecule-magnets
#16
Alberto Cini, Matteo Mannini, Federico Totti, Maria Fittipaldi, Gabriele Spina, Aleksandr Chumakov, Rudolf Rüffer, Andrea Cornia, Roberta Sessoli
The use of single molecule magnets (SMMs) as cornerstone elements in spintronics and quantum computing applications demands that magnetic bistability is retained when molecules are interfaced with solid conducting surfaces. Here, we employ synchrotron Mössbauer spectroscopy to investigate a monolayer of a tetrairon(III) (Fe4) SMM chemically grafted on a gold substrate. At low temperature and zero magnetic field, we observe the magnetic pattern of the Fe4 molecule, indicating slow spin fluctuations compared to the Mössbauer timescale...
February 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29389761/classifications-in-brief-the-thoracolumbar-injury-classification
#17
Erik Magnusson, Nicholas Spina, Navin D Fernando
No abstract text is available yet for this article.
January 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29388500/a-detailed-description-of-the-short-term-musculoskeletal-and-cognitive-effects-of-prolonged-standing-for-office-computer-work
#18
Richelle Baker, Pieter Coenen, Erin Howie, Jeremy Lee, Ann Williamson, Leon Straker
Due to concerns about excessive sedentary exposure for office workers, alternate work positions such as standing are being trialled. However, prolonged standing may have health and productivity impacts, which this study assessed. Twenty adult participants undertook two hours of laboratory-based standing computer work to investigate changes in discomfort and cognitive function, along with muscle fatigue, movement, lower limb swelling and mental state. Over time, discomfort increased in all body areas (total body IRR[95% confidence interval]: 1...
February 1, 2018: Ergonomics
https://www.readbyqxmd.com/read/29379999/lumbar-paraspinal-muscle-fat-infiltration-is-independently-associated-with-sex-age-and-inter-vertebral-disc-degeneration-in-symptomatic-patients
#19
Julio Urrutia, Pablo Besa, Daniel Lobos, Mauricio Campos, Cristobal Arrieta, Marcelo Andia, Sergio Uribe
PURPOSE: To determine the association of paraspinal muscles and psoas relative cross-sectional area (RCSA) and fat signal fraction (FSF) with sex, age, and intervertebral disc degeneration (IDD) in symptomatic patients. METHODS: We retrospectively evaluated 80 adult patients with spinal symptoms using T2-weighted magnetic resonance images. We determined RCSA and FSF of the paraspinal muscles (erector spinae and multifidus) and psoas from L1-L2 to L5-S1; we determined IDD using the Pfirrmann classification...
January 29, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29370900/continuous-erector-spinae-plane-block-for-analgesia-in-pediatric-thoracic-surgery-a-case-report
#20
C Gaio-Lima, C C Costa, J B Moreira, T S Lemos, H L Trindade
Erector spinae plane block has been recently described and it appears as a very promising regional analgesia technique. We report the first continuous erector spinae plane block performed in a pediatric patient for thoracic surgery. A 15-month-old boy, diagnosed with a paracardiac teratoma was scheduled for a tumor resection with a thoracotomy approach. After general anesthesia induction, a continuous erector spinae plane block at T5 level was performed with ropivacaine 0.2%. After surgery, a continuous thoracic interfascial infusion of ropivacaine 0...
January 19, 2018: Revista Española de Anestesiología y Reanimación
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