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https://www.readbyqxmd.com/read/30013665/microrna-539-inhibits-colorectal-cancer-progression-by-directly-targeting-sox4
#1
Jian Zhao, Jian Xu, Rui Zhang
Colorectal cancer (CRC) is the third most prevalent cancer and the fourth most common cause of cancer-associated mortality in males and females globally. Aberrant expression of microRNA-539 (miR-539) has been reported in multiple types of cancer. However, miR-539 expression, function and underlying mechanisms have not been clearly elucidated in CRC. In the present study, miR-539 expression was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in CRC tissues and cell lines. The effects of miR-539 on CRC cells were further examined in in vitro studies...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013394/prognostic-and-predictive-value-of-the-macroscopic-growth-pattern-in-patients-undergoing-curative-resection-of-colorectal-cancer-a-single-institution-retrospective-cohort-study-of-4-080-chinese-patients
#2
Xiao Li, Qi Zhao, Bang An, Jianni Qi, Wenwen Wang, Di Zhang, Zhen Li, Chengyong Qin
Purpose: The purpose of this study was to determine whether macroscopic growth patterns had an impact on the prognosis of colorectal cancer (CRC) patients with different tumor-node-metastasis (TNM) stages and responses to chemotherapy in stage III patients. Patients and methods: We retrospectively recruited 4,080 stage I-III CRC patients who underwent curative resection at Shandong Provincial Hospital affiliated to Shandong University. All patients were grouped by macroscopic growth patterns (expansive, infiltrative and ulcerative subtypes), and stage III patients were further divided into chemotherapy and nonchemotherapy groups...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30012939/prognostic-impact-of-preoperative-lymphocyte-to-monocyte-ratio-in-patients-with-colorectal-cancer-with-special-reference-to-myeloid-derived-suppressor-cells
#3
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Suguru Hayase, Wataru Sakamoto, Hirokazu Okayama, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono
AIMS: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. PATIENTS AND METHODS: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors...
July 14, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30012100/variables-affecting-penetrance-of-gastric-and-duodenal-phenotype-in-familial-adenomatous-polyposis-patients
#4
Danielle C Sample, N Jewel Samadder, Lisa M Pappas, Kenneth M Boucher, Wade S Samowitz, Therese Berry, Michelle Westover, Deepika Nathan, Priyanka Kanth, Kathryn R Byrne, Randall W Burt, Deborah W Neklason
BACKGROUND: Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the duodenal and gastric polyp phenotype in a cohort of 150 FAP patients undergoing pre-screening for a chemoprevention trial and analyze variables that may affect recommendations for surveillance...
July 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/30008836/value-of-combined-detection-of-serum-carcino-embryonic-antigen-carbohydrate-antigen-19-9-and-cyclooxygenase-2-in-the-diagnosis-of-colorectal-cancer
#5
Weili Yang, Yongsheng Luo, Shuangcheng Hu, Ying Li, Qing Liu
The aim of the present study was to investigate the value of combined detection of serum carcino-embryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and cyclooxygenase-2 (COX-2) in the diagnosis of colorectal cancer. A total of 50 patients with colorectal cancer were selected as Group A and 50 healthy subjects as the control group. A sample of 2 ml fasting venous blood was drawn from patients in each group, and serum CEA, CA19-9 and COX-2 were detected using electrochemiluminescence analyzer and ELISA. Receiver operating characteristic curve analysis was performed on analyze the sensitivity and specificity of diagnostic methods for colorectal cancer patients at different stages...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30008427/long-non-coding-rna-crnde-in-cancer-prognosis-review-and-meta-analysis
#6
REVIEW
Haibiao Xie, Bo Ma, Qunjun Gao, Hengji Zhan, Yuchen Liu, Zhicong Chen, Shaobo Ye, Jianfa Li, Lin Yao, Weiren Huang
BACKGROUND: Colorectal neoplasia differentially expressed (CRNDE), a 1910-nt lncRNA encoded on human chromosome 16, has been found to be involved in various cancers. Nevertheless, the clinical and diagnostic values of CRNDE in tumors still need to be explored. In this review, we aimed to elucidate the clinical role of CRNDE in cancer by searching all correlative literature, and we sequentially explored the association between CRNDE levels and overall survival (OS) or clinicopathological characteristics of cancer...
July 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30005993/minimally-invasive-management-of-the-entire-treatment-sequence-in-patients-with-stage-iv-colorectal-cancer-a-propensity-score-weighting-analysis
#7
Claire Goumard, Y Nancy You, Masayuki Okuno, Onur Kutlu, Hsiang-Chun Chen, Eve Simoneau, Eduardo A Vega, Yun-Shin Chun, C David Tzeng, Cathy Eng, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: In patients with stage IV colorectal cancer (CRC), minimally invasive surgery (MIS) may offer optimal oncologic outcome with low morbidity. However, the relative benefit of MIS compared to open surgery in patients requiring multistage resections has not been evaluated. METHODS: Patients who underwent totally minimally invasive (TMI) or totally open (TO) resections of CRC primary and liver metastases (CLM) in 2009-2016 were analyzed. Inverse probability of weighted adjustment by propensity score was performed before analyzing risk factors for complications and survival...
July 10, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29992570/a-novel-tumor-based-epithelial-to-mesenchymal-transition-score-that-associates-with-prognosis-and-metastasis-in-patients-with-stage-ii-iii-colorectal-cancer
#8
A K Roseweir, C Y Kong, J H Park, Lindsay Bennett, A G M T Powell, J Quinn, H C van Wyk, P G Horgan, D C McMillan, Joanne Edwards, C S Roxburgh
It is increasingly appreciated that host factors within the tumor centre and microenvironment play a key role in dictating colorectal cancer (CRC) outcomes. As a result, the metastatic process has now been defined as a result of epithelial-mesenchymal transition (EMT). Establishment of the role of EMT within the tumor centre and its effect on the tumor microenvironment would be beneficial for prognosis and therapeutic intervention in CRC. The present study assessed five immunohistochemical EMT markers within the tumor centre on a 185 stage II/III CRC patient TMA...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29991500/ror%C3%AE-t-expressing-tregs-drive-the-growth-of-colitis-associated-colorectal-cancer-by-controlling-il6-in-dendritic-cells
#9
Angelamaria Rizzo, Martina Di Giovangiulio, Carmine Stolfi, Eleonora Franzè, Hans-Joerg Fehling, Rita Carsetti, Ezio Giorda, Alfredo Colantoni, Angela Ortenzi, Massimo Rugge, Claudia Mescoli, Giovanni Monteleone, Massimo C Fantini
Chronic inflammation drives colitis-associated colorectal cancer (CAC) in inflammatory bowel disease (IBD). FoxP3+ regulatory T cells (Tregs) co-expressing the Th17-related transcription factor RORγt accumulate in the lamina propria of IBD patients, where they are thought to represent an intermediate stage of development toward a Th17 proinflammatory phenotype. However, the role of these cells in CAC is unknown. RORγt+FoxP3+ cells were investigated in human samples of CAC, and their phenotypic stability and function were investigated in an azoxymethane/dextran sulfate sodium model of CAC using Treg fate mapping reporter and Treg-specific RORγt conditional knockout mice...
July 10, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29989291/acetone-clearance-of-the-mesocolic-and-mesorectal-fat-increases-lymph-node-yield-and-may-improve-detection-of-high-risk-stage-ii-colorectal-cancer
#10
C A W Leung, G Fazzi, J Melenhorst, D Rennspiess, H I Grabsch
AIMS: The lymph node (LN) status is key to determining the need for adjuvant therapy in colorectal cancer and for disease which has progressed to stage II (T3-T4, N0, M0. A LN yield of less than 12 is considered a risk factor similar to high grade histology, vascular, lymphatic and perineural invasion. The object of this retrospective study was to investigate the effect of acetone fat clearance of the mesocolon and mesorectum on LN yield and the identification of high risk stage II CRC patients...
July 10, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29986714/the-tgf%C3%AE-signaling-pathway-and-colorectal-cancer-associations-between-dysregulated-genes-and-mirnas
#11
Andrew J Pellatt, Lila E Mullany, Jennifer S Herrick, Lori C Sakoda, Roger K Wolff, Wade S Samowitz, Martha L Slattery
BACKGROUND: The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been seen as key events in CRC progression. METHODS: In this study we comprehensively evaluate differential gene expression (RNASeq) of 81 genes in the TGFβ-signaling pathway and evaluate how dysregulated genes are associated with miRNA expression (Agilent Human miRNA Microarray V19...
July 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29981320/ergothioneine-ameliorates-oxaliplatin-induced-peripheral-neuropathy-in-rats
#12
Kentaro Nishida, Kazuya Takeuchi, Ayami Hosoda, Shohei Sugano, Eri Morisaki, Akihiro Ohishi, Kazuki Nagasawa
AIMS: Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the transporters responsible for the accumulation in DRG neurons is organic cation transporter novel (OCTN) 1. Here, we examined whether co-administration of ergothioneine, a substrate/inhibitor of OCTN1, with l-OHP could prevent this peripheral neuropathy...
July 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29976257/differences-in-gene-mutations-according-to-gender-among-patients-with-colorectal-cancer
#13
Yi-Jian Tsai, Sheng-Chieh Huang, Hung-Hsin Lin, Chun-Chi Lin, Yuan-Tzu Lan, Huann-Sheng Wang, Shung-Haur Yang, Jeng-Kai Jiang, Wei-Shone Chen, Tzu-Chen Lin, Jen-Kou Lin, Shih-Ching Chang
BACKGROUND: The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. METHODS: A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans' General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI...
July 5, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29968159/circadian-clock-pathway-genes-associated-with-colorectal-cancer-risk-and-prognosis
#14
Dongying Gu, Shuwei Li, Shuai Ben, Mulong Du, Haiyan Chu, Zhengdong Zhang, Meilin Wang, Zuo-Feng Zhang, Jinfei Chen
Circadian clock genes influence biological processes and may be involved in tumorigenesis. We systematically evaluated genetic variants in the circadian clock pathway genes associated with colorectal cancer risk and survival. We evaluated the association of 119 single nucleotide polymorphisms (SNPs) in 27 circadian clock pathway genes with the risk of colorectal cancer in a case-control study (1150 cases and 1342 controls). The false discovery rate (FDR) method was applied to correct for multiple comparisons...
July 2, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29957060/transcriptional-signatures-for-coupled-predictions-of-stage-ii-and-iii-colorectal-cancer-metastasis-and-fluorouracil-based-adjuvant-chemotherapy-benefit
#15
Kai Song, You Guo, Xianlong Wang, Hao Cai, Weicheng Zheng, Na Li, Xuekun Song, Lu Ao, Zheng Guo, Wenyuan Zhao
The current study suggests that the identification of predictive signatures of fluorouracil (5-FU) response for stage II and III colorectal cancer (CRC) could be confounded by chemotherapy-irrelevant low relapse risk. Using the samples of patients with stage II and III CRC who were treated with curative surgery only, we identified a signature with which to predict chemotherapy-irrelevant relapse risk for patients after curative surgery. By applying this signature to the samples of patients with stage II and III CRC who were treated with 5-FU-based adjuvant chemotherapy (ACT) after surgery, we predicted the relapse risk if treated with surgery only...
June 29, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29955607/high-vimentin-expression-predicts-a-poor-prognosis-and-progression-in-colorectal-cancer-a-study-with-meta-analysis-and-tcga-database
#16
REVIEW
Le Du, Jingchuan Li, Lei Lei, Hongjuan He, Erfei Chen, Jing Dong, Jin Yang
The aim of this study was to evaluate the role of vimentin expression in the prognosis and progression of CRC. Meta-analysis was conducted to investigate the correlations between vimentin and prognosis and clinicopathological features in CRC. Literatures were searched by PubMed, Embase, ClinicalKey, CNKI, VIP, and WanFang databases. The Cancer Genome Atlas (TCGA) database was used to assess the association of vimentin expression with survival rate in CRC. Eleven reports with 1969 cases were included in the meta-analysis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29948417/cost-effectiveness-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-management-of-colorectal-peritoneal-carcinomatosis
#17
Z J Lee, S L Chia, G Tan, K C Soo, C C M Teo
BACKGROUND: Peritoneal carcinomatosis from colorectal cancer is a stage 4 disease for which palliative chemotherapy has traditionally been considered the mainstay of treatment. Since the development of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) by Sugarbaker, this combined method treatment has resulted in improved survival outcomes with acceptable morbidity for selected patients with peritoneal carcinomatosis. This study examined the cost effectiveness of CRS and HIPEC compared with palliative chemotherapy for patients with peritoneal carcinomatosis from colorectal cancer within the context of the Singaporean health care system...
June 8, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29948357/phase-ii-study-of-dfp-10917-a-deoxycytidine-analog-given-by-14-day-continuous-intravenous-infusion-for-chemotherapy-refractory-advanced-colorectal-cancer
#18
Amir Mehrvarz Sarshekeh, Henry Q Xiong, Kenzo Iizuka, Howard S Hochster, Scott Kopetz
Background DFP-10917 is a cytotoxic deoxycytidine analogue that causes DNA fragmentation, G2 /M-phase arrest, and apoptosis. This agent has been shown to have antitumor activity against colorectal cancer (CRC) in preclinical studies and to be tolerable in patients. The purpose of our phase II trial was to evaluate the safety, efficacy and pharmacogenomics of DFP-10917 as well as DNA damage studies in patients with advanced CRC refractory to cytotoxic chemotherapy. Methods In this single-arm, Simon two-stage, phase II trial, patients with chemotherapy-refractory advanced CRC received 2...
June 13, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29948240/colorectal-obstruction-is-a-potential-prognostic-factor-for-stage-ii-colorectal-cancer
#19
Yusuke Okuda, Takaya Shimura, Tomonori Yamada, Yoshikazu Hirata, Ryuzo Yamaguchi, Eiji Sakamoto, Hiromi Kataoka
BACKGROUND: Obstructive colorectal cancer (CRC) is an emergency situation with high morbidity and mortality, but long-term outcomes of stage II/III obstructive CRC remain unclear. The aim of this study was to evaluate prognostic factors, including colorectal obstruction. METHODS: Data were retrospectively reviewed from consecutive patients with stage II/III CRC who underwent curative surgery between January 2007 and December 2011 at two Japanese institutions. We analyzed overall survival (OS) and relapse-free survival (RFS), according to various prognostic factors including colorectal obstruction...
June 15, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29947991/primary-tumor-versus-liver-first-approach-for-synchronous-colorectal-liver-metastases-an-association-fran%C3%A3-aise-de-chirurgie-afc-multicenter-based-study-with-propensity-score-analysis
#20
Francesco Esposito, Chetana Lim, Antonio Sa Cunha, Patrick Pessaux, Francis Navarro, Daniel Azoulay
OBJECTIVES: Multicenter studies comparing the reverse strategy (RS) with the classical strategy (CS) for the management of stage IVA liver-only colorectal cancer (CCR) are scarce. The aim of this study was to compare long-term survival and recurrence patterns following use of the CS and RS. METHOD: This retrospective multicenter review collected data from all consecutive patients with stage IVA liver-only CCR who underwent staged resection of CCR and liver metastases (LM) at 24 French hospitals between 2006 and 2013 and were retrospectively analyzed...
June 14, 2018: World Journal of Surgery
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