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Stage 4 colorectal cancer

Abdurakhim Toychiev, Sulayman Abdujapparov, Alim Imamov, Behzod Navruzov, Nikolay Davis, Najiya Badalova, Svetlana Osipova
The purpose of the present study was to determine the prevalence of intestinal helminths and protozoa in colorectal cancer (CRC) patients and to evaluate the possible association between the prevalence and CRC pathogenesis. A total of 200 CRC patients and 200 residents of Tashkent, who had no complaints related to the gastrointestinal tract, were examined by triple coproscopy using a concentration method and estimations of protozoan infection intensity. Of the CRC patients tested, 144 were classified as T1 -4 N0 M0 (without metastases) and 56 were classified as T1-4 N1-2 M0-1 (with metastases)...
September 15, 2018: Parasitology Research
Wagdy M Eldehna, Alessio Nocentini, Sara T Al-Rashood, Ghada S Hassan, Hamad M Alkahtani, Abdulrahman A Almehizia, Ahmed M Reda, Hatem A Abdel-Aziz, Claudiu T Supuran
Three series of indolinone-based sulfonamides (3a-f, 6a-f and 9a-f) were in vitro evaluated as inhibitors of the tumor-associated carbonic anhydrase (CA, EC isoforms hCA IX and XII, using a stopped-flow CO2 hydrase assay. All the investigated sulfonamides displayed single- or double-digit nanomolar inhibitory activities towards both hCA IX (KI s: 6.2-64.8 nM) and XII (KI s: 7.1-55.6 nM) isoforms. All sulfonamides (3a-f, 6a-f and 9a-f) were in vitro examined for their potential anticancer activity against colorectal cancer HCT-116 and breast cancer MCF-7 cell lines...
September 7, 2018: Bioorganic Chemistry
Chuanjia Yang, Weixue Xu, Xiangzhen Meng, Siqi Zhou, Minglu Zhang, Dongxu Cui
SCC-S2 overexpression has been implicated in several human cancers, its correlation with prognosis and the mechanism how it reserved biological roles are still uncertain. The current study demonstrated that, in 142 archived colorectal carcinoma (CRC) tissue samples, SCC-S2 expression was significantly correlated with higher histological grade ( p=0.001), tumor invasion ( p=0.001), advanced Dukes staging ( p=0.002), positive regional lymph node metastasis ( p=0.024), and poor overall survival ( p<0.001). MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and Transwell assays showed that SCC-S2 significantly promoted the proliferation and invasion...
September 14, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
Hiroshi Shiratori, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Kazuhito Sasaki, Manabu Kaneko, Koji Murono, Shigenobu Emoto, Teppei Morikawa, Masashi Fukayama, Hiroaki Nozawa
OBJECTIVE: Factors that predict rectal cancer metastasis to the lungs remain undefined. We investigated whether the lateral pelvic lymph node (LPN) sizes before and after chemoradiotherapy (CRT) correlate with lung metastasis after surgery for lower rectal cancer. METHODS: Two hundred and forty patients with lower rectal cancer who received preoperative CRT and curative surgery between 2003 and 2017 were examined. Computed tomography-measured LPN sizes before and after CRT were retrospectively determined by 1 colorectal surgeon who was blinded to the patients' clinical and pathological outcomes...
September 13, 2018: Oncology
Hsiang-Ling Wu, Ying-Hsuan Tai, Shih-Pin Lin, Min-Ya Chan, Hsiu-Hsi Chen, Kuang-Yi Chang
Whether blood transfusion exacerbates cancer outcomes after surgery in humans remains inconclusive. We utilized a large cohort to investigate the effect of perioperative blood transfusion on cancer prognosis following colorectal cancer (CRC) resection. Patients with stage I through III CRC undergoing tumour resection at a tertiary medical center between 2005 and 2014 were identified and evaluated through August 2016. Propensity score matching was used to cancel out imbalances in patient characteristics. Postoperative disease-free survival (DFS) and overall survival (OS) were analysed using Cox regression model...
September 6, 2018: Scientific Reports
Hasan Jalaeikhoo, Ahmad Khajeh-Mehrizi, Mohammad Zokaasadi, Mohsen Rajaeinejad, Seied Asadollah Mousavi, Mohammad Vaezi, Hosein Kamranzadeh Fumani, Manoutchehr Keyhani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
BACKGROUND Colorectal cancer (CRC) is one of the most common cancers worldwide. Recently treatments of advanced CRC have been immensely improved. In this study we reported the current state of advanced CRC in Iran regarding treatment and outcomes from 2000 to 2016. METHODS 370 subjects with stage III or IV of the disease were included in this study. Pathological subtypes other than adenocarcinoma were excluded. Demographics and other relevant clinical data were collected. RESULTS Mean age at diagnosis was 55...
July 2018: Middle East Journal of Digestive Diseases
Dianne Zakaria
INTRODUCTION: Several sets of multiple primary rules have been used in Canada to determine whether a cancer is new and little is known of the impact on cancer statistics. We examine the effect of rules on the magnitude and trend of age-standardized incidence rates (ASIRs) of cancer in Canada between 1992 and 2012. METHODS: Cancer- and sex-specific ASIRs were estimated using Canadian Cancer Registry (CCR) rules and the more conservative International Agency for Research on Cancer (IARC) rules...
December 0: Journal of Registry Management
Victoria L Champion, Shannon M Christy, William Rakowski, Wambui G Gathirua-Mwangi, Will L Tarver, Lisa Carter-Harris, Andrea A Cohee, Andrew R Marley, Nenette M Jessup, Erika Biederman, Carla D Kettler, Timothy E Stump, Patrick Monahan, David R Lairson, Susan M Rawl
BACKGROUND: Colorectal cancer mortality could be decreased with risk-appropriate cancer screening. We examined the efficacy of three tailored interventions compared to Usual Care for increasing screening adherence. METHODS: Women (n=1196) ages 51 to 74, from primary care networks and non-adherent to colorectal cancer guidelines were randomized to: 1) Usual Care, 2) tailored Web intervention, 3) tailored Phone intervention, or 4) tailored Web + Phone intervention...
September 4, 2018: Cancer Epidemiology, Biomarkers & Prevention
Pēteris Alberts, Andra Tilgase, Agnija Rasa, Katrīna Bandere, Dite Venskus
Oncolytic viruses are a fast-developing cancer treatment field. Numerous viruses have been tested in clinical trials and three are approved. The first, Rigvir, is an immunomodulator with anti-tumour effect for treatment of melanoma, local treatment of skin and subcutaneous metastases of melanoma, for prevention of relapse and metastasis after radical surgery registered in Latvia, Georgia, Armenia and Uzbekistan. The aim of the present review is to summarize the development of Rigvir. Approximately 60 viruses were screened preclinically...
September 1, 2018: European Journal of Pharmacology
Jun Hwa Lee, Seung Eun Yu, Kyung-Hee Kim, Myung Hyun Yu, In-Hye Jeong, Jae Youl Cho, Sang-Jae Park, Woo Jin Lee, Sung-Sik Han, Tae Hyun Kim, Eun Kyung Hong, Sang Myung Woo, Byong Chul Yoo
Background: Pancreatic cancer (PC) and biliary tract cancer (BTC) are highly aggressive cancers, characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. Diagnosis of PC and BTC is complex and is made using a combination of appropriate clinical suspicion, imaging and endoscopic techniques, and cytopathological examination. However, the late-stage detection and poor prognosis of this tumor have led to an urgent need for biomarkers for early and/or predictive diagnosis and improved personalized treatments...
September 2018: EPMA Journal
Diane Willis, Emmanuelle Samalin, Daniel Satgé
People with intellectual disabilities (PWIDs) are now living longer; thus, the incidence of cancer within this population is increasing. Available data indicate an excess of digestive tract cancers in PWIDs, but colorectal cancer has rarely been specifically studied and has not been extensively reviewed. This is despite risk factors such as being overweight, obesity, and lack of exercise being more frequent in PWIDs. In this article, we examine the literature on the frequency, screening, and treatment of colorectal cancer in PWIDs by as sessing 4 databases, Medline, EBSCO-CINHL, ASSIA, and PsychLIT, from 1970 to February 2017...
August 31, 2018: Oncology
Rebeca García Agudo, Sami Aoufi Rabih, Pedro González Carro, Francisco Pérez Roldán, Beatriz Proy Vega, Ángel Arias Arias, Fátima Cazalla Cadenas, José María Tenías Burillo, Ana Fernández Rodríguez
INTRODUCTION: Despite the frequency with which anaemia is present in patients with chronic kidney disease (CKD), its relationship with gastrointestinal lesions has not been studied. METHOD: A cross-sectional, analytical, observational study involving one year of recruitment was carried out to determine the prevalence of endoscopic gastrointestinal lesions and associated risk factors in asymptomatic patients with chronic kidney disease stages 1-5 and anaemia who had a positive qualitative immunochemical faecal occult blood test...
August 25, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Manabu Kaneko, Shigenobu Emoto, Koji Murono
BACKGROUND/AIM: Several risk factors for recurrence have been identified in stage II colorectal cancer. However, in contrast to stage III, the benefits of adjuvant chemotherapy for these patients remain controversial. We hypothesized that the different impacts of chemotherapy may be due to different patterns of recurrence between these stages. The aim of this study was to characterize recurrence in high-risk stage II colorectal cancer (CRC) in comparison with stage III. PATIENTS AND METHODS: A total of 442 patients with curatively resected stage III and high-risk stage II CRCs were evaluated...
September 2018: In Vivo
Ronald C Newland, Charles Chan, Pierre H Chapuis, Anil Keshava, Matthew J F X Rickard, Christopher J Young, Owen F Dent
The pTNM staging system for colorectal cancer (CRC) is not entirely effective in discriminating between potentially curative and non-curative resections because it does not account for local residual tumour in patients with stages I, II or III. This study aimed to evaluate the prognostic importance of histologically verified tumour in any line of resection of the bowel resection specimen (TLR) in relation to pTNM stages and to demonstrate how TLR may be integrated into pTNM staging. Information on patients in the period 1995 to 2010 with complete follow-up to the end of 2015 was extracted from a prospective database of CRC resections...
August 24, 2018: Pathology
Chiara Di Girolamo, Sarah Walters, Carolynn Gildea, Sara Benitez Majano, Bernard Rachet, Melanie Morris
BACKGROUND: Cancer Waiting Time targets have been integrated into successive cancer strategies as indicators of cancer care quality in England. These targets are reported in national statistics for all cancers combined, but there is mixed evidence of their benefits and it is unclear if meeting Cancer Waiting Time targets, as currently defined and published, is associated with improved survival for individual patients, and thus if survival is a good metric for judging the utility of the targets...
2018: PloS One
Gabriel Glockzin, Florian Zeman, Roland S Croner, Alfred Königsrainer, Jörg Pelz, Michael A Ströhlein, Beate Rau, Dirk Arnold, Michael Koller, Hans J Schlitt, Pompiliu Piso
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as parts of an interdisciplinary treatment concept including systemic chemotherapy can improve survival of selected patients with peritoneal metastatic colorectal cancer (pmCRC). Nevertheless, the sequence of the therapeutic options is still a matter of debate. Thus, the COMBATAC (COMBined Anticancer Treatment of Advanced Colorectal cancer) trial was conducted to evaluate a combined treatment regimen consisting of preoperative systemic polychemotherapy + cetuximab followed by CRS + HIPEC and postoperative systemic polychemotherapy + cetuximab...
July 31, 2018: Clinical Colorectal Cancer
Hao Duan, Zhen-Qiang He, Cheng-Cheng Guo, Jue-Hui Li, Jian Wang, Zhe Zhu, Ke Sai, Zhong-Ping Chen, Xiao-Bing Jiang, Yong-Gao Mou
Purpose: The presence of brain metastasis (BM) in patients with colorectal cancer (CRC) is usually associated with terminal-stage illness; however, a subgroup of patients receiving aggressive treatment can have a satisfactory prognosis. This study was designed to investigate the profile of prognostic factors in CRC patients with BM treated aggressively. Patients and methods: CRC patients with BM were retrospectively reviewed. Survival analysis was performed to identify potential prognostic factors in the entire cohort of patients and a subgroup of patients treated aggressively...
2018: Cancer Management and Research
Eugenia N Uche-Anya, Nicole DeCuir, Benjamin Lebwohl
BACKGROUND: Colonoscopy is effective for colorectal cancer (CRC) prevention, yet patients may develop CRC despite adhering to screening/surveillance intervals. There are limited data on predictive factors associated with these postcolonoscopy CRCs (PCCRCs). We aimed to measure PCCRC rates and identify risk factors for PCCRC. METHODS: We performed a case-control study, comparing patients with PCCRCs to spontaneous CRCs diagnosed during a 12.5-year period at an academic medical center...
August 16, 2018: Journal of Clinical Gastroenterology
Xiao Tan, Zhongqiang Zhang, Hongliang Yao, Liangfang Shen
T-cell immunoglobulin domain and mucin domain-4 (Tim-4) is overexpressed in several tumors and is correlated with enhanced tumor development and metastasis. In this study, we investigated the physiological alterations and molecular events related to Tim-4 overexpression in a mouse model of colorectal cancer (CRC). In the current study, we observed that Tim-4 is upregulated in CRC tissues compared with neighboring normal tissues. In addition, statistical analysis revealed that elevated Tim-4 expression was strongly linked to distant metastasis, TNM stage and reduced overall survival duration in CRC patients...
November 1, 2018: Cancer Letters
Iddrisu B Yabasin, Jaceline G P Sanches, Mohammed M Ibrahim, Jin Huidan, Walana Williams, Zhi-Li Lu, Qingping Wen
Colorectal cancer (CRC) is reported to be the third and fourth, most diagnosed and cause of cancer associated deaths respectively. In 2012 for instance, about 1.4 million new cases were reported, and approximately 700,000 deaths recorded. Survival from CRC is dependent on the stage at which it is diagnosed coupled with appropriate surgical and medical intervention. Cisatracurium is widely used for skeletal muscle relaxation during abdominal surgeries, including bowel and colon surgeries. Recent studies reported that cisatracurium inhibits progression of human cancer cells, however, the mechanisms leading to the inhibition are yet to be completely understood...
2018: Frontiers in Physiology
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