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https://www.readbyqxmd.com/read/29146641/menopausal-hormone-therapy-and-colorectal-cancer-a-linkage-between-nationwide-registries-in-norway
#1
Edoardo Botteri, Nathalie C Støer, Solveig Sakshaug, Sidsel Graff-Iversen, Siri Vangen, Solveig Hofvind, Thomas de Lange, Vincenzo Bagnardi, Giske Ursin, Elisabete Weiderpass
OBJECTIVES: With the present study, we aimed to investigate the association between menopausal hormone therapy (HT) and risk of colorectal cancer (CRC). SETTING: Cohort study based on the linkage of Norwegian population-based registries. PARTICIPANTS: We selected 466822 Norwegian women, aged 55-79, alive and residing in Norway as of 1 January 2004, and we followed them from 2004 to 2008. Each woman contributed person-years at risk as non-user, current user and/or past HT user...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146523/factors-that-contribute-to-differences-in-survival-of-black-vs-white-patients-with-colorectal-cancer
#2
Helmneh M Sineshaw, Kimmie Ng, W Dana Flanders, Otis W Brawley, Ahmedin Jemal
BACKGROUND & AIMS: Previous studies reported that black vs white disparities in survival among elderly patients with colorectal cancer (CRC) were due to differences in tumor characteristics (tumor stage, grade, nodal status, and comorbidity) rather than differences in treatment. We sought to determine the sequential contribution of differences in insurance, comorbidity, tumor characteristics, and treatment receipt to the black-white survival disparity among patients with CRC in 18-64 years old...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29142750/evaluation-of-epidermal-growth-factor-receptor-serum-levels-and-their-association-with-clinicopathological-characteristics-in-patients-with-colorectal-cancer
#3
Mehmet Karabulut, Cigdem Usul Afsar, Halil Alıs, Ebru Oran, Senem Karabulut, Cevher Akarsu, Nuri Alper Sahbaz, Alpen Yahya Gümüsoglu, Elif Bilgin, Nuri Faruk Aykan
Colorectal cancer (CRC) is a major public health concern and one of the leading causes of cancer-related mortality worldwide. The aim of the present study was to determine the serum epidermal growth factor receptor (sEGFR) levels in healthy volunteers and patients with CRC, to determine the association between tumor marker levels and clinicopathological findings, and investigate its prognostic value. A total of 140 patients with CRC were enrolled in the present study. Pre-treatment sEGFR levels were determined using ELISA...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29138933/population-based-screening-improves-histopathological-prognostic-factors-in-colorectal-cancer
#4
Mónica Mengual-Ballester, Enrique Pellicer-Franco, Graciela Valero-Navarro, Victoriano Soria-Aledo, José Andrés García-Marín, José Luis Aguayo-Albasini
INTRODUCTION: Diagnosis of colorectal cancer (CRC) based on clinical symptoms is usually established in its advanced stages. One strategy for reducing mortality is the early detection and removal of preneoplastic and initial neoplastic lesions, even before the first symptoms appear, by means of population-based screening campaigns. The aim of the present study is to determine whether CRC diagnosed via a screening campaign has more favourable histopathological prognostic factors than when diagnosed in the symptomatic phase...
November 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29137421/gper-mediates-differential-effects-of-estrogen-on-colon-cancer-cell-proliferation-and-migration-under-normoxic-and-hypoxic-conditions
#5
Viviana Bustos, Áine M Nolan, Anke Nijhuis, Harry Harvey, Alexandra Parker, Richard Poulsom, Jean McBryan, Warren Thomas, Andrew Silver, Brian J Harvey
The estrogen receptor ERβ is the predominant ER subtype expressed in normal well-differentiated colonic epithelium. However, ERβ expression is lost under the hypoxic microenvironment as colorectal cancer (CRC) malignancy progresses. This raises questions about the role of signalling through other estrogen receptors such as ERα or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17β-estradiol (E2) under hypoxic conditions after ERβ is lost in CRC progression. We tested the hypothesis that E2 or hypoxia can act via GPER to contribute to the altered phenotype of CRC cells...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137287/n-myc-downstream-regulated-gene-1-promotes-apoptosis-in-colorectal-cancer-via-up-regulating-death-receptor-4
#6
Xian Zhang, Bo Feng, Fan Zhu, Chaoran Yu, Jiaoyang Lu, Meng Pan, Zirui He, Xiongzhi Wangpu, Jing Sun, Xiao Yang
The aim of this study was to evaluate the clinical significance of N-myc downstream-regulated gene 1 (NDRG1) in colorectal cancer (CRC) patients and to explore the mechanisms governing the role of NDRG1 in apoptosis of CRC cells. In the current study, we found that NDRG1 was a prognostic marker of CRC patients. Moreover, NDRG1 expression negatively correlated to tumor size and clinical TNM stage, suggesting that NDRG1 might act as a tumor suppressor by inhibiting proliferation or inducing apoptosis in CRC. Consistently, substantial apoptosis was observed in vitro and in vivo in the presence of NDRG1...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135092/the-prognostic-role-of-skp2-and-the-tumor-suppressor-protein-p27-in-colorectal-cancer
#7
Ovidiu Vasile Bochis, Patriciu Achimas-Cadariu, Catalin Vlad, Bogdan Fetica, Daniel Corneliu Leucuta, Constantin Ioan Busuioc, Alexandru Irimie
PURPOSE: This study aimed at exploring the role of Skp2, p27 and Cks1 expression as prognostic factors for colorectal cancer (CRC) patients, and to identify a correlation between their expression and the cell proliferation marker Ki67. METHODS: We conducted a retrospective study on 130 patients with CRC treated with surgery and adjuvant treatment at the Oncology Institute Cluj-Napoca between 2006- 2010. The Skp2, p27, Cks1 and Ki67 immunoexpression was grouped from 1 to 4, according to percents of tumor cells with nuclear reactivity...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29131639/proteomic-characterization-of-transcription-and-splicing-factors-associated-with-a-metastatic-phenotype-in-colorectal-cancer
#8
Sofia Torres, Irene Garcia-Palmero, Consolación Marin-Vicente, Ruben A Bartolome, Eva Calviño, María Jesús Fernandez-Aceñero, J Ignacio Casal
We investigated new transcription and splicing factors associated with the metastatic phenotype in colorectal cancer. A concatenated tandem array of consensus transcription factors (TFs)-response elements was used to pull down nuclear extracts in two different pairs of colorectal cancer cells, KM12SM/KM12C and SW620/480, genetically-related but differing in metastatic ability. Proteins were analyzed by label-free LC-MS and quantified with MaxLFQ. We found 240 proteins showing a significant dysregulation in highly-metastatic KM12SM cells relative to non-metastatic KM12C cells and 257 proteins in metastatic SW620 versus SW480...
November 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29131521/high-hsf4-expression-is-an-independent-indicator-of-poor-overall-survival-and-recurrence-free-survival-in-patients-with-primary-colorectal-cancer
#9
Yingchi Yang, Lan Jin, Jinghui Zhang, Jin Wang, Xiaomu Zhao, Guocong Wu, Hongwei Yao, Zhongtao Zhang
Heat shock factor 4 (HSF4) is a member of the HSF family. In this study, by using data from the Cancer Genome Atlas-Colorectal Cancer (TCGA-CRC), we investigated the expression profile and the prognostic value of the HSF4 in terms of overall survival (OS) and recurrence free survival (RFS) in CRC patients. RNA-Seq data showed that HSF4 RNA expression was significantly higher in CRC tissues (N = 380) than in the corresponding normal tissues (N = 51) (mean ± SD: 3.56 ± 1.28 vs. 1.85 ± 0...
November 13, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29115932/prognostic-and-clinicopathological-significance-of-circulating-tumor-cells-detected-by-rt-pcr-in-non-metastatic-colorectal-cancer-a-meta-analysis-and-systematic-review
#10
Chaogang Yang, Kun Zou, Liang Zheng, Bin Xiong
BACKGROUND: Circulating tumor cells (CTCs) have been accepted as a prognostic marker in patients with metastatic colorectal cancer (mCRC, UICC stage IV). However, the prognostic value of CTCs in patients with non-metastatic colorectal cancer (non-mCRC, UICC stage I-III) still remains in dispute. A meta-analysis was performed to investigate the prognostic significance of CTCs detected by the RT-PCR method in patients diagnosed with non-mCRC patients. METHODS: A comprehensive literature search for relevant articles was performed in the EmBase, PubMed, Ovid, Web of Science, Cochrane library and Google Scholar databases...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29112018/tumor-budding-and-pdc-grade-are-stage-independent-predictors-of-clinical-outcome-in-mismatch-repair-deficient-colorectal-cancer
#11
Éanna Ryan, Yi Ling Khaw, Ben Creavin, Robert Geraghty, Elizabeth J Ryan, David Gibbons, Ann Hanly, Sean T Martin, P Ronan O'Connell, Desmond C Winter, Kieran Sheahan
Mismatch repair deficient (dMMR) colorectal cancer (CRC) despite its association with poor histologic grade often has improved prognosis compared with MMR proficient CRC. Tumor budding and poorly differentiated clusters (PDCs) may predict metastatic potential of colorectal adenocarcinoma (CRC). In addition, their assessment may be more reproducible than the evaluation of other histopathologic parameters. Therefore, we wished to determine their potential as prognostic indicators in a cohort of dMMR CRC patients relative to histologic grade...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29101262/genome-wide-dna-methylation-analysis-reveals-a-prognostic-classifier-for-non-metastatic-colorectal-cancer-promcol-classifier
#12
Melanie Gündert, Dominic Edelmann, Axel Benner, Lina Jansen, Min Jia, Viola Walter, Phillip Knebel, Esther Herpel, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Barbara Burwinkel
OBJECTIVE: Pathological staging used for the prediction of patient survival in colorectal cancer (CRC) provides only limited information. DESIGN: Here, a genome-wide study of DNA methylation was conducted for two cohorts of patients with non-metastatic CRC (screening cohort (n=572) and validation cohort (n=274)). A variable screening for prognostic CpG sites was performed in the screening cohort using marginal testing based on a Cox model and subsequent adjustment of the p-values via independent hypothesis weighting using the methylation difference between 34 pairs of tumour and normal mucosa tissue as auxiliary covariate...
November 3, 2017: Gut
https://www.readbyqxmd.com/read/29098294/fiber-intake-and-survival-after-colorectal-cancer-diagnosis
#13
Mingyang Song, Kana Wu, Jeffrey A Meyerhardt, Shuji Ogino, Molin Wang, Charles S Fuchs, Edward L Giovannucci, Andrew T Chan
Importance: Although high dietary fiber intake has been associated with a lower risk of colorectal cancer (CRC), it remains unknown whether fiber benefits CRC survivors. Objective: To assess the association of postdiagnostic fiber intake with mortality. Design, Setting, and Participants: A total of 1575 health care professionals with stage I to III CRC were evaluated in 2 prospective cohorts, Nurses' Health Study and Health Professionals Follow-up Study...
November 2, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29081665/clinical-significance-of-fusobacterium-nucleatum-epithelial-mesenchymal-transition-and-cancer-stem-cell-markers-in-stage-iii-iv-colorectal-cancer-patients
#14
Xuebing Yan, Liguo Liu, Hao Li, Huanlong Qin, Zhenliang Sun
Colorectal cancer (CRC) is a common digestive malignancy and emerging studies have closely linked its initiation and development with gut microbiota changes. Fusobacterium nucleatum (Fn) has been recently identified as a pathogenic bacteria for CRC; however, its prognostic significance for patients is poorly investigated and is less for patients within late stage. Therefore, in this study, we made efforts to analyze its level and prognostic significance in a retrospective cohort of 280 stage III/IV CRC patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29079854/identification-of-mst1-as-a-potential-early-detection-biomarker-for-colorectal-cancer-through-a-proteomic-approach
#15
Jiekai Yu, Xiaohui Zhai, Xiaofen Li, Chenhan Zhong, Cheng Guo, Fuquan Yang, Ying Yuan, Shu Zheng
Colorectal cancer (CRC) is a common malignant neoplasm worldwide. It is important to identify new biomarkers for the early detection of CRC. In this study, magnetic beads and the Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) platform were used to analyse CRC and healthy control (HC) serum samples. The CRC diagnosis pattern was established to have a specificity of 94.7% and sensitivity of 92.3% in a blind test. The candidate biomarker serine/threonine kinase 4 (STK4, also known as MST1) was identified by Tandem mass spectrometry (MS/MS) and verified with western blotting and enzyme-linked immunosorbent assay (ELISA)...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079411/capecitabine-versus-s-1-as-adjuvant-chemotherapy-for-patients-with-stage-iii-colorectal-cancer-jcog0910-an-open-label-non-inferiority-randomised-phase-3-multicentre-trial
#16
Tetsuya Hamaguchi, Yasuhiro Shimada, Junki Mizusawa, Yusuke Kinugasa, Yukihide Kanemitsu, Masayuki Ohue, Shoichi Fujii, Nobuhiro Takiguchi, Toshimasa Yatsuoka, Yasumasa Takii, Hitoshi Ojima, Hiroyuki Masuko, Yoshiro Kubo, Hideyuki Mishima, Takashi Yamaguchi, Hiroyuki Bando, Toshihiko Sato, Takeshi Kato, Kenichi Nakamura, Haruhiko Fukuda, Yoshihiro Moriya
BACKGROUND: Adjuvant chemotherapy with oral fluoropyrimidine alone after D3/D2 lymph node dissection improves disease-free survival and overall survival in patients with stage III colon cancer. Adjuvant S-1 has been shown to be non-inferior to uracil and tegafur plus leucovorin in terms of disease-free survival. This study aims to confirm the non-inferiority of S-1 compared with capecitabine as adjuvant treatment in patients with stage III colorectal cancer. METHODS: This study was an open-label, non-inferiority, randomised, phase 3, multicentre trial done in 56 Japanese centres to assess the non-inferiority of S-1 to capecitabine as adjuvant chemotherapy...
October 24, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29076812/surgical-outcomes-in-patients-with-hepatic-synchronous-and-metachronous-colorectal-metastasis
#17
Maria Laura Cossu, Giorgio Carlo Ginesu, Claudio Francesco Feo, Alessandro Fancellu, Antonio Pinna, Isabel Vargiu, Francesca Addis, Michele Barmina, Giovanni Sotgiu, Alberto Porcu
AIM: To evaluate the impact of several clinical and pathological factors on the outcomes of surgery for hepatic colorectal cancer metastasis. METHODS: Eighty-four liver metastasectomies in 77 consecutive patients with 90 colorectal cancer hepatic metastases were performed in our institution from 2009 to 2014. Surgery was carried out in 75 cases, as two patients were not eligible for surgery. Among them 43 (Group A) were affected by synchronous, and 32 (Group B) by metachronous lesions...
October 25, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29066696/-relationship-between-surgical-site-infection-ssi-incidence-and-prognosis-in-colorectal-cancer-surgery
#18
Masano Sagawa, Hajime Yokomizo, Kazuhiko Yoshimatsu, Yuki Yano, Sachiyo Okayama, Akiko Sakuma, Masaya Satake, Yasufumi Yamada, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
We examined the relationship between risk factors for surgical site infections(SSIs)and prognosis in 440 patients who underwent colon cancer surgery. We evaluated factors related to SSIs(GradeB II)and compared survival rates by stage. SSIs were observed in 36 patients. An increased SSI incidence was associated with pulmonary dysfunction, mGPS=2, CONUT≥2, PNI≤40, NLR>4.3, location(rectum), depth of tumor invasion(Bsubserosa, SS), lymph node metastasis, laparotomy, resection of other organs, colostomy, blood loss(large), and operative time(long)...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29065595/a-benchmark-for-endoluminal-scene-segmentation-of-colonoscopy-images
#19
David Vázquez, Jorge Bernal, F Javier Sánchez, Gloria Fernández-Esparrach, Antonio M López, Adriana Romero, Michal Drozdzal, Aaron Courville
Colorectal cancer (CRC) is the third cause of cancer death worldwide. Currently, the standard approach to reduce CRC-related mortality is to perform regular screening in search for polyps and colonoscopy is the screening tool of choice. The main limitations of this screening procedure are polyp miss rate and the inability to perform visual assessment of polyp malignancy. These drawbacks can be reduced by designing decision support systems (DSS) aiming to help clinicians in the different stages of the procedure by providing endoluminal scene segmentation...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29055146/association-between-natural-killer-cell-activity-and-the-risk-of-colorectal-neoplasia
#20
Yoon Suk Jung, Min-Jung Kwon, Dong Il Park, Chong Il Sohn, Jung Ho Park
BACKGROUND: Low activity of natural killer (NK) cells is known to be associated with higher risk of cancer, especially with poor prognosis and the presence of colorectal cancer (CRC). We investigated whether NK cells activity differs between subjects with and without colorectal neoplasia (CRN). METHODS: A cross-sectional study was performed on 1818 asymptomatic examinees aged ≥30 years who underwent NK cell activity test (which quantitates the amount of interferon-γ secreted into the plasma by NK cells) and a colonoscopy as part of a health check-up...
October 21, 2017: Journal of Gastroenterology and Hepatology
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