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Stage 4 colorectal cancer

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https://www.readbyqxmd.com/read/28088319/ercc1-and-ercc2-as-predictive-biomarkers-to-oxaliplatin-based-chemotherapy-in-colorectal-cancer-patients-from-egypt
#1
Amira B Kassem, Salem EidSalem, Mohamed E Abdelrahim, Amira S A Said, Ahmad Salahuddin, Marwa Mahmoud Hussein, Abeer A Bahnassy
BACKGROUND: The impact of Excision repair cross-complementation group 1 (ERCC1) and group 2 (ERCC2) expression levels on the efficacy of oxaliplatin-based chemotherapy is still controversial. The present study was conducted to determine the predictive value of these molecular biomarkers in stage III and IV colorectal cancer (CRC) patients receiving oxaliplatin (OX) - based chemotherapy as first-line treatment. METHODS: The study included 80 CRC patients who received first line oxaliplatin based chemotherapy The expression levels of ERCC1 and ERCC2-mRNA and proteins were determined in the primary tumors by quantitative real time reverse transcription polymerase chain reaction(RT-qPCR) and immunohistochemistry (IHC); respectively...
January 11, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28081292/the-utility-of-abbreviated-patient-reported-outcomes-for-predicting-survival-in-early-stage-colorectal-cancer
#2
Tina Hsu, Caroline H Speers, Hagen F Kennecke, Winson Y Cheung
BACKGROUND: Patient-reported outcomes (PROs) are increasingly used in clinical settings. Prior research suggests that PROs collected at baseline may be associated with cancer survival, but most of those studies were conducted in patients with breast or lung cancer. The objective of this study was to determine the correlation between prospectively collected PROs and cancer-specific outcomes in patients with early stage colorectal cancer. METHODS: Patients who had newly diagnosed stage II or III colorectal cancer from 2009 to 2010 and had a consultation at the British Columbia Cancer Agency completed the brief Psychosocial Screen for Cancer (PSSCAN) questionnaire, which collects data on patients' perceived social supports, quality of life (QOL), anxiety and depression, and general health...
January 12, 2017: Cancer
https://www.readbyqxmd.com/read/28078433/a-meta-analysis-of-the-clinicopathological-characteristics-and-survival-outcomes-of-inflammatory-bowel-disease-associated-colorectal-cancer
#3
REVIEW
Ian S Reynolds, Aobhlinn O'Toole, Joseph Deasy, Deborah A McNamara, John P Burke
PURPOSE: The current study aims to use meta-analytical techniques to compare the clinicopathological characteristics and survival outcomes of inflammatory bowel disease (IBD) associated and sporadic colorectal carcinoma (CRC). Patients with IBD have an established increased risk of developing CRC. There is no consensus, however, on the clinicopathological characteristics and survival outcomes of IBD associated CRC when compared to sporadic CRC. METHODS: A comprehensive search for published studies comparing IBD associated and sporadic CRC was performed...
January 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28065524/effects-of-age-after-laparoscopic-right-colectomy-for-cancer-are-there-any-specific-outcomes
#4
Christine Denet, David Fuks, Francesca Cocco, Sophie Chopinet, Marcel Abbas, Cyprian Costea, Hugues Levard, Thierry Perniceni, Brice Gayet
BACKGROUND: Laparoscopic approach in colorectal surgery has demonstrated to give advantages in terms of postoperative outcomes, particularly in high-risk patients. The aim was to assess the impact of patients' age on the short-term outcomes after laparoscopic right colectomy for cancer. METHODS: From January 2004 to September 2014, all patients who underwent laparoscopic right colectomy for cancer in a single institution were divided into four groups (A: <64 years; B: 65-74 years; C: 75-84 years; D ≥85 years)...
December 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28052576/pre-operative-oral-nutritional-supplementation-with-dietary-advice-versus-dietary-advice-alone-in-weight-losing-patients-with-colorectal-cancer-single-blind-randomized-controlled-trial
#5
Sorrel T Burden, Debra J Gibson, Simon Lal, James Hill, Mark Pilling, Mattias Soop, Aswatha Ramesh, Chris Todd
BACKGROUND: Pre-operative weight loss has been consistently associated with increased post-operative morbidity. The study aims to determine if pre-operative oral nutritional supplements (ONSs) with dietary advice reduce post-operative complications. METHODS: Single-blinded randomized controlled trial. People with colorectal cancer scheduled for surgery with pre-operative weight loss >1 kg/3-6 months were randomized by using stratified blocks (1:1 ratio) in six hospitals (1 November 2013-28 February 2015)...
January 3, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28052033/glut-1-overexpression-as-an-unfavorable-prognostic-biomarker-in-patients-with-colorectal-cancer
#6
Jing Yang, Jing Wen, Tian Tian, Zhongsheng Lu, Yao Wang, Zikai Wang, Xiangdong Wang, Yunsheng Yang
BACKGROUND: Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis. MATERIALS AND METHODS: Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures. RESULTS: A total of 14 studies with 2,077 patients were included in this meta-analysis...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28050782/colorectal-cancer-in-inflammatory-bowel-diseases-a-population-based-study-in-utah
#7
N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Mary Bronner, Cornelia M Ulrich, Randall W Burt, Karen Curtin, Ken R Smith
BACKGROUND AND AIMS: The molecular, endoscopic, and histological features of IBD-associated CRC differ from sporadic CRC. The objective of this study was to describe the prevalence, clinical features, and prognosis of IBD-associated CRC compared to patients with sporadic CRC in a US statewide population-based cohort. METHODS: All newly diagnosed cases of CRC between 1996 and 2011 were obtained from Utah Cancer Registry. IBD was identified using a previously validated algorithm, from statewide databases of Intermountain Healthcare, University of Utah Health Sciences, and the Utah Population Database...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28044264/clinicopathological-associations-of-k-ras-and-n-ras-mutations-in-indonesian-colorectal-cancer-cohort
#8
Michael Levi, Gintang Prayogi, Farid Sastranagara, Edi Sudianto, Grace Widjajahakim, Winiarti Gani, Albert Mahanadi, Jocelyn Agnes, Bela Haifa Khairunisa, Ahmad R Utomo
BACKGROUND: K-RAS and recently N-RAS gene mutation testing are mandatory requirements prior to anti-epidermal growth factor receptor (EGFR) monoclonal antibody treatment of metastatic CRC. Mutation prevalence and distribution in Indonesian colorectal cancer (CRC) are not known. METHODS: Combined methods of PCR high-resolution melt (HRM), restriction fragment length polymorphism (RFLP), and direct DNA sequencing were used to genotype exons 2, 3, and 4 of both K-RAS and N-RAS genes for routine clinical testing of CRC patients...
January 3, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28040840/black-patients-with-colorectal-cancer-have-more-advanced-cancer-stage-at-time-of-diagnosis-a-community-based-safety-net-hospital-experience
#9
Chuck Chan, Aristeo Lopez, Garland Castaneda, Taft Bhuket, Benny Liu, Stephen Yee, David Irwin, Robert J Wong
Colorectal cancer (CRC) remains a leading cause of morbidity and mortality in the U.S. Disparities in access to care contribute to advanced CRC stage at diagnosis, and these disparities are most pronounced among underserved populations and ethnic minorities. We aim to evaluate race/ethnicity-specific disparities in CRC stage at diagnosis among an ethnically diverse, urban safety-net hospital. We retrospectively evaluated all adult CRC patients diagnosed from January 1, 2009 to October 1, 2015. CRC cases were confirmed by histopathology specimens from biopsies and/or surgical resection...
December 31, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/28035516/circadian-rhythm-of-methylated-septin-9-cell-free-dna-amount-and-tumor-markers-in-colorectal-cancer-patients
#10
Kinga Tóth, Árpád V Patai, Alexandra Kalmár, Barbara Kinga Barták, Zsófia Brigitta Nagy, Orsolya Galamb, Barnabás Wichmann, Zsolt Tulassay, Béla Molnár
To determine the level of cell-free DNA (cfDNA), Septin 9 (SEPT9) and tumor markers (CEA, AFP, CA19-9, TPA, CA72-4). Plasma samples were collected four times a day (06:00, 12:00, 18:00, 24:00) from 9 patients with CRC (5 stage I-II, 4 stage III-IV), from one with colorectal adenoma and from one healthy control. CfDNA was isolated, quantified and bisulfite-converted. CfDNA and methylated SEPT9 were determined by RT-PCR. Plasma levels of conventional tumor markers were also measured. The lowest cfDNA concentrations were observed at 24:00 and 18:00 in stage I-III patients...
December 30, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28030817/cd44v6-overexpression-related-to-metastasis-and-poor-prognosis-of-colorectal-cancer-a-meta-analysis
#11
Ji-Lin Wang, Wen-Yu Su, Yan-Wei Lin, Hua Xiong, Ying-Xuan Chen, Jie Xu, Jing-Yuan Fang
CD44v6 has recently been reported as a biomarker for colorectal cancer. However, the clinical and prognostic significance of CD44v6 in colorectal cancer remains controversial. Therefore, we performed a meta-analysis to clarify this issue. A comprehensive literature search was performed using Medline, Embase and Web of Science, and the statistical analysis was conducted using Stata software. A total of twenty-one studies including 3918 colorectal cancer cases were included. The pooled analysis showed that CD44v6 overexpression in colorectal cancer was an independent prognostic marker correlating with lower 5-year overall survival rate (OR=0...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029327/tumor-deposits-in-colorectal-cancer-improving-the-value-of-modern-staging-a-systematic-review-and-meta-analysis
#12
Iris D Nagtegaal, Nikki Knijn, Niek Hugen, Helen C Marshall, Kenichi Sugihara, Tibor Tot, Hideki Ueno, Philip Quirke
Purpose Colorectal cancer (CRC) treatment is largely determined by tumor stage. Despite improvements made in the treatment of various types of metastatic disease, staging has not been refined. The role of tumor deposits (TDs) in staging remains debated. We have assessed the relation of TDs with metastatic pattern to evaluate whether TDs might add significant new information to staging. Methods We performed a systematic literature search that was focused on the role of TDs in CRC. Studies with neoadjuvant-treated patients were excluded...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28018106/elevated-fibrinogen-plasma-level-is-not-an-independent-predictor-of-poor-prognosis-in-a-large-cohort-of-western-patients-undergoing-surgery-for-colorectal-cancer
#13
Corrado Pedrazzani, Guido Mantovani, Gian Luca Salvagno, Elisabeth Baldiotti, Andrea Ruzzenente, Calogero Iacono, Giuseppe Lippi, Alfredo Guglielmi
AIM: To evaluate the clinical significance of the preoperative fibrinogen plasma level as a prognostic marker after surgery for colorectal cancer. METHODS: This retrospective study analysed 652 patients undergoing surgery for stage I-IV colorectal cancer between January 2005 and December 2012, at the Division of General Surgery A, University of Verona Hospital Trust, in whom preoperative fibrinogen plasma values were assessed at baseline. Fibrinogen is involved in tumourigenesis as well as tumour progression in several malignancies...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28010732/the-effect-of-a-germline-mutation-in-the-apc-gene-on-%C3%AE-catenin-in-human-embryonic-stem-cells
#14
Nofar Yedid, Yael Kalma, Mira Malcov, Ami Amit, Revital Kariv, Michal Caspi, Rina Rosin-Arbesfeld, Dalit Ben-Yosef
BACKGROUND: Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads to the development of polyps that will turn malignant if not removed. It is not fully understood which molecular mechanisms are activated by APC loss and when the loss of the second APC allele occurs...
December 23, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27998467/-expression-and-significance-of-serum-microrna-135a-5p-level-in-colorectal-cancer
#15
Q J Wang, H C Zhang, X J Shen, S Q Ju
Objective: To explore the expression level of serum miR135a-5p and its diagnostic value in colorectal cancer (CRC). Methods: Serum samples were randomly collected from 60 primary CRC patients, 40 patients with intestinal polyps and 50 healthy controls, and the serum concentrations of miR135a-5p, CEA and CA199 were detected. The relationships between serum miR135a-5p level and clinicopathological parameters were analyzed by Mann-Whitney U test. The correlation of serum miR135a-5p level and serum concentrations of CEA or CA199 was analyzed by Pearson's correlation test...
December 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27997895/lower-expression-of-spry4-predicts-a-poor-prognosis-and-regulates-cell-proliferation-in-colorectal-cancer
#16
Xiaoling Zhou, Sheng Xie, Chunluan Yuan, Li Jiang, Xiaoyan Huang, Liumei Li, Yan Chen, Lichuan Luo, Jianxuan Zhang, Daogang Wang, Lijian Liu, Wei Shi, Liang Han, Nong Tang, Yunxi Ji
BACKGROUND/AIMS: Colorectal cancer (CRC) is the third most common type of cancer worldwide. Sprouty proteins are modulators of mitogeninduced signal transduction processes and therefore can influence the process of cancerogenesis. The encoded protein of Sprouty homolog 4 (SPRY4) is associated with various human cancers. However, its biological role and clinical significance in CRC development and progression are unknown. METHODS: The aim of this study was to evaluate the expression and biological role of SPRY4 in colorectal cancer...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27995451/survival-and-prognostic-factors-for-metachronous-peritoneal-metastasis-in-patients-with-colon-cancer
#17
Hiroshi Nagata, Soichiro Ishihara, Keisuke Hata, Koji Murono, Manabu Kaneko, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Toshiaki Watanabe
BACKGROUND: The clinical course of metachronous peritoneal metastasis of colorectal origin is poorly understood. In this retrospective study, we aimed to elucidate survival and prognostic factors for metachronous peritoneal metastasis. METHODS: Patients with metachronous peritoneal metastasis after curative resection for stage I-III colon cancer were retrospectively reviewed, and the incidence and prognosis of metachronous peritoneal metastasis were investigated...
December 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27995001/evaluation-of-the-patients-with-colorectal-cancer-undergoing-emergent-curative-surgery
#18
Fikri Kundes, Metin Kement, Kenan Cetin, Levent Kaptanoglu, Aytaç Kocaoglu, Mehmet Karahan, Serkan Fatih Yegen, Ali Emre Atici, Osman Civil, Mehmet Eser, Tebessum Cakir, Nejdet Bildik
BACKGROUND: The aim of our study is to evaluate perioperative and mid-term oncologic outcomes of the patients with colorectal cancer, who underwent emergent curative surgery. METHODS: The study included all patients with colorectal cancer, who underwent surgery for curative intent between 1 January 2012 and 31 December 2014 in General Surgery Department of Kartal Training and Research Hospital. The patients were divided into two groups according to the type of admission (emergent or elective)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27993206/local-and-systemic-th17-immune-response-associated-with-advanced-stage-colon-cancer
#19
Stephen P Sharp, Dorina Avram, Steven C Stain, Edward C Lee
BACKGROUND: Little is known about how the immunologic microenvironment changes during tumor progression and metastatic spread. Recently, murine models have shown the T-helper 17 (Th17) pathway to play an important role in promoting colorectal cancer (CRC). The purpose of this study was to compare cytokine profiles in the tumor microenvironment of CRC between local disease (stages I/II) and advanced disease (stages III/IV), and to determine whether these changes were manifest in the systemic circulation of patients with advanced disease...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993203/prognostic-significance-of-systemic-inflammatory-response-in-stage-ii-colorectal-cancer
#20
Seung Yeop Oh, Young Bae Kim, Kwang Wook Suh
BACKGROUND: It is considered that stage II colorectal cancers have heterogeneous oncological outcomes. It remains to be determined whether inflammatory markers can predict survival after curative surgery in these patients. The aim of this study was to investigate the prognostic impact of preoperative inflammatory markers after curative surgery in stage II colorectal cancers. METHODS: Two hundred sixty-one patients with stage II colorectal cancers who underwent curative surgery between January 2006 and December 2011 were reviewed...
February 2017: Journal of Surgical Research
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