Veronica Marcoux, Stacey D Lok, Prosanta Mondal, Deborah Assayag, Jolene H Fisher, Shane Shapera, Julie Morisset, Hélène Manganas, Charlene D Fell, Nathan Hambly, P Gerard Cox, Martin Kolb, Andrea S Gershon, Teresa To, Mohsen Sadatsafavi, Nasreen Khalil, Alyson W Wong, Pearce G Wilcox, Christopher J Ryerson, Thao Vu, Kerri A Johannson
BACKGROUND AND OBJECTIVE: Establishing an accurate and timely diagnosis of idiopathic pulmonary fibrosis (IPF) is essential for appropriate management and prognostication. In some cases, surgical lung biopsy (SLB) is performed but carries non-negligible risk. The objective of this retrospective study was to determine if SLB is associated with accelerated lung function decline in patients with IPF using the Canadian Registry for Pulmonary Fibrosis. METHODS: Linear mixed models and Cox proportional hazards regression models were used to compare decline in forced vital capacity (FVC)%, diffusion capacity of the lung (DLCO%) and risk of death or lung transplantation between SLB and non-SLB patients...
March 4, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology