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Adélaïde Compaoré, Susan Dierickx, Fatou Jaiteh, Alain Nahum, Towanou Francis Emmanuel Bohissou, Halidou Tinto, Susana Scott, Umberto D'Alessandro, Henk Schallig, Koen Peeters Grietens
BACKGROUND: A multi-country, community-based trial on scheduled screening and treatment for malaria in pregnancy was conducted in Benin, The Gambia and Burkina Faso. Despite standardized procedures and outcomes, the study became subject to rumours and accusations of placenta being sold for mystical and financial gain by trial staff, leading to drop-out rates of 30% and the consequent halting of placental biopsy sampling in Benin. This paper explores the role of socio-cultural beliefs related to placenta and identified additional factors contributing these rumours...
November 15, 2018: Malaria Journal
Lowry A Kirkby, Francisco J Luongo, Morgan B Lee, Mor Nahum, Thomas M Van Vleet, Vikram R Rao, Heather E Dawes, Edward F Chang, Vikaas S Sohal
Human brain networks that encode variation in mood on naturalistic timescales remain largely unexplored. Here we combine multi-site, semi-chronic, intracranial electroencephalography recordings from the human limbic system with machine learning methods to discover a brain subnetwork that correlates with variation in individual subjects' self-reported mood over days. First we defined the subnetworks that influence intrinsic brain dynamics by identifying regions that showed coordinated changes in spectral coherence...
October 29, 2018: Cell
Einat Levy-Gigi, Shilat Haim-Nahum, Julie M Hall, Jacob Crouse, Robyn Winwood-Smith, Simon J G Lewis, Ahmed A Moustafa
Cognitive deficits in Parkinson's disease (PD) have increasingly been recognized over the last decade and reversal learning in particular has received a great deal of attention. In a classical reversal-learning paradigm, participants learn to associate various stimuli with specific responses (i.e. A →Positive; B→ Negative), and subsequently learn to associate the same stimuli with opposite outcomes (i.e., A→Negative; B→ Positive). Prior studies have revealed that medicated PD patients have a selective impairment with learning from negative, but not positive, outcomes, even when both reward- and punishment-related stimuli were equally relevant...
November 6, 2018: Neuroscience Letters
Nadav Teich, Dmitry Pevni, Rephael Mohr, Nahum Nesher, Amir Kramer, Yosef Paz, Yanai Ben-Gal
BACKGROUND: The use of two bilateral internal thoracic artery grafting (BITA) was shown to lead to survival benefit. However, operators are reluctant to use BITA with peripheral vascular disease (PVD) because of concerns of increased rates of sternal wound infection and lack of studies supporting survival benefit compared with single internal thoracic artery (SITA) grafting. The aim of this study is to compare outcome BITA grafting versus of SITA and vein grafts in PVD patients. PATIENTS AND METHODS: Six hundred and twenty-one PVD patients who underwent BITA between 1996 and 2011 were compared with 372 patients who underwent SITA...
November 6, 2018: Coronary Artery Disease
Colin D H Ratcliffe, Nadeem Siddiqui, Paula P Coelho, Nancy Laterreur, Tumini N Cookey, Nahum Sonenberg, Morag Park
Differential inclusion or skipping of microexons is an increasingly recognized class of alternative splicing events. However, the functional significance of microexons and their contribution to signaling diversity is poorly understood. The Met receptor tyrosine kinase (RTK) modulates invasive growth and migration in development and cancer. Here, we show that microexon switching in the Arf6 guanine nucleotide exchange factor cytohesin-1 controls Met-dependent cell migration. Cytohesin-1 isoforms, differing by the inclusion of an evolutionarily conserved three-nucleotide microexon in the pleckstrin homology domain, display differential affinity for PI(4,5)P2 (triglycine) and PI(3,4,5)P3 (diglycine)...
November 7, 2018: Journal of Cell Biology
Michaël Cerezo, Ramdane Guemiri, Sabine Druillennec, Isabelle Girault, Hélène Malka-Mahieu, Shensi Shen, Delphine Allard, Sylvain Martineau, Caroline Welsch, Sandrine Agoussi, Charlène Estrada, Julien Adam, Cristina Libenciuc, Emilie Routier, Séverine Roy, Laurent Désaubry, Alexander M Eggermont, Nahum Sonenberg, Jean Yves Scoazec, Alain Eychène, Stéphan Vagner, Caroline Robert
Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potential efficacy biomarker, but the complex mechanisms underlying its regulation are not completely understood. Here, we show that the eukaryotic translation initiation complex, eIF4F, which binds the 5' cap of mRNAs, regulates the surface expression of interferon-γ-induced PD-L1 on cancer cells by regulating translation of the mRNA encoding the signal transducer and activator of transcription 1 (STAT1) transcription factor...
October 29, 2018: Nature Medicine
Shaked Perek, Nahum Kiryati, Gali Zimmerman-Moreno, Miri Sklair-Levy, Eli Konen, Arnaldo Mayer
PURPOSE: Contrast-enhanced spectral mammography (CESM) is a recently developed breast imaging technique. CESM relies on dual-energy acquisition following contrast agent injection to improve mammography sensitivity. CESM is comparable to contrast-enhanced MRI in terms of sensitivity, at a fraction of the cost. However, since lesion variability is large, even with the improved visibility provided by CESM, differentiation between benign and malignant enhancement is not accurate and a biopsy is usually performed for final assessment...
October 26, 2018: International Journal of Computer Assisted Radiology and Surgery
Yoav Nahum, Reut Israeli, Gabriel Mircus, Ilana Perelshtein, Miriam Ehrenberg, Shay Gutfreund, Aharon Gedanken, Irit Bahar
PURPOSE: This work examined the antibacterial and physical effects of a novel Zn-CuO nanocoating applied on a silicone hydrogel contact lens. METHODS: Zn-CuO coating of PureVision balafilcon-A soft contact lenses (Bausch&Lomb, Rochester, NY) was performed by sonochemical deposition using a high-intensity ultrasonic horn. Non-coated PureVision lenses served as a control in all experiments. Adhesion assays for P. aerueginosa and S. epidermidis to the coated lenses were performed to identify the minimal coating concentration which still possessed antibacterial activity...
October 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Ilse Gantois, Jelena Popic, Arkady Khoutorsky, Nahum Sonenberg
Fragile X syndrome (FXS) is the most frequent inherited form of intellectual disability and autism spectrum disorder. Loss of the fragile X mental retardation protein, FMRP, engenders molecular, behavioral, and cognitive deficits in FXS patients. Experiments using different animal models advanced our knowledge of the pathophysiology of FXS and led to the discovery of many targets for drug treatments. In this review, we discuss the potential of metformin, an antidiabetic drug approved by the US Food and Drug Administration, to correct core symptoms of FXS and other neurological disorders in humans...
October 26, 2018: Annual Review of Medicine
Fan Gao, Nahum Méndez-Sánchez, Xingshun Qi
No abstract text is available yet for this article.
August 2018: Annals of Translational Medicine
Avichai Weissbach, Noy Zur, Eytan Kaplan, Gili Kadmon, Yulia Gendler, Elhanan Nahum
OBJECTIVES: Acute kidney injury in the critically ill pediatric population is associated with worse outcome. The aim of this study was to assess the prevalence, associated clinical variables, and outcomes of acute kidney injury in children admitted to the PICU with diabetic ketoacidosis. DESIGN: Retrospective cohort. SETTING: PICU of a tertiary, university affiliated, pediatric medical center. PATIENTS: All children less than age 18 years with a primary diagnosis of diabetic ketoacidosis admitted to the PICU between November 2004 and October 2017...
October 24, 2018: Pediatric Critical Care Medicine
Nahum Méndez-Sánchez
No abstract text is available yet for this article.
October 1, 2018: Minerva Medica
Giovanni Mauri, Nicolò Gennaro, Stefano De Beni, Tiziana Ierace, S Nahum Goldberg, Marcello Rodari, Luigi Alessandro Solbiati
PURPOSE: To assess the feasibility of US-18 FDG-PET/CT fusion-guided microwave ablation of liver metastases either poorly visible or totally undetectable with US, CEUS and CT, but visualized by PET imaging. MATERIALS AND METHODS: Twenty-three patients with 58 liver metastases underwent microwave ablation guided by image fusion system that combines US with 18 FDG-PET/CT images. In 28/58 tumors, 18 FDG-PET/CT with contrast medium (PET/CECT) was used. The registration technical feasibility, registration time, rates of correct targeting, technical success at 24 h, final result at 1 year and complications were analyzed and compared between the PET/CT and PET/CECT groups...
October 4, 2018: Cardiovascular and Interventional Radiology
Jia Zhu, Xingshun Qi, Haonan Yu, Eric M Yoshida, Nahum Mendez-Sanchez, Xintong Zhang, Ran Wang, Han Deng, Jing Li, Dan Han, Xiaozhong Guo
Background: Hepatic encephalopathy is associated with altered gut microbiota. Proton pump inhibitors increase the risk of small bowel bacterial overgrowth. Objectives: This was a case-control study aimed at exploring the relationship of proton pump inhibitor use with the risk of hepatic encephalopathy during hospitalization in liver cirrhosis. Methods: Case and control groups were defined as cirrhotic patients who developed hepatic encephalopathy during hospitalization and those without hepatic encephalopathy at admission or during hospitalization, respectively...
October 2018: United European Gastroenterology Journal
Alon Zahavi, Ronit Friling, Yonina Ron, Miriam Ehrenberg, Yoav Nahum, Moshe Snir
PURPOSE: To evaluate changes in ocular motility deviation with cycloplegic eye drop examination compared to the prism adaptation test in patients with strabismus. METHODS: The medical charts were reviewed of all patients who underwent primary strabismus surgery in our center from December 2013 to July 2015. Data collected included demographics, medical history, and findings on pre-operative ophthalmic/orthoptic examination. Ocular motility deviation was measured before instillation of cycloplegic eye drops, immediately after maximal dilation (end point), and 10 and 20 min later...
October 4, 2018: European Journal of Ophthalmology
Timna Naftali, Adi Eindor-Abarbanel, Nahum Ruhimovich, Ariella Bar-Gil Shitrit, Fabiana Sklerovsky-Benjaminov, Fred Konikoff, Shay Matalon, Haim Shirin, Yael Milgrom, Tomer Ziv-Baran, Efrat Broide
Introduction: Since individuals with IBD typically experience symptoms during their prime years of employment, it raises the question about IBD impact on employment status. Most studies concentrated on absenteeism from work with varying results in different populations. However, absenteeism reflects only one dimension of the ability to work and does not expose the problem of inability to hold a full-time job. Aims: To evaluate the influence of IBD on unemployment and working hours in Israel...
2018: Canadian Journal of Gastroenterology & Hepatology
Shinban Liu, Kelly Nahum, George Ferzli
No abstract text is available yet for this article.
September 27, 2018: BMJ Case Reports
Lung-Yi Mak, Vania Cruz-Ramón, Paulina Chinchilla-López, Harrys A Torres, Noelle K LoConte, John P Rice, Lewis E Foxhall, Erich M Sturgis, Janette K Merrill, Howard H Bailey, Nahum Méndez-Sánchez, Man-Fung Yuen, Jessica P Hwang
The incidence rate of hepatocellular carcinoma (HCC) is rising. It is one of the most common cancers worldwide and accounts for substantial morbidity and mortality. Chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, and nonalcoholic fatty liver disease (NAFLD) are the most important etiologies of HCC, and effective screening and management strategies are crucial to reduce the HCC risk. For HBV, which accounts for the majority of HCC cases, most infections were acquired via perinatal and early horizontal transmission...
May 23, 2018: American Society of Clinical Oncology Educational Book
Ofer N Gofrit, Igal Rabinovich, Vladimir Yutkin, Dov Pode, Mordechai Duvdevani, Ezekiel H Landau, Guy Hidas, S Nahum Goldberg
INTRODUCTION: Postoperative surveillance protocols after nephrectomy for kidney cancer include periodic computed tomography (CT) scans of the chest and abdomen. A single study exposes the patient to 21 mSv (equivalent to 7-year exposure to natural background radiation). The objective of this study was to evaluate the hypothesis that an abbreviated CT protocol restricted to the chest and upper abdomen (i.e., to the level of the intervertebral disk L3-L4) is sufficient for routine postnephrectomy follow-up as it detects most tumor recurrence with lower radiation exposure...
November 2018: Urologic Oncology
Nahum Méndez-Sánchez, Xingshun Qi
No abstract text is available yet for this article.
August 2018: Annals of Translational Medicine
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