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https://www.readbyqxmd.com/read/27852471/what-does-extinction-have-to-do-with-confabulation
#1
REVIEW
Armin Schnider, Louis Nahum, Radek Ptak
Behaviourally spontaneous confabulation denotes a distinct syndrome consisting of confabulations that patients act upon, disorientation, and amnesia. It corresponds to the stable form of the original Korsakoff syndrome. While the syndrome may also occur in confusional states and degenerative dementia, this article is about the syndrome as it occurs after acute and focal brain damage. The patients act according to ideas and obligations that can mostly be traced back to real experiences in their past, but which are not currently valid guides of thinking and behaviour...
November 1, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27821895/health-care-utilization-of-mexican-patients-with-medically-unexplained-physical-symptoms
#2
Azucena Maribel Rodriguez González, José Manuel Ramírez Aranda, Homero de Los Santos Reséndiz, María Yolanda Lara Duarte, Santiago Oscar Pazaran Zanella, Jafet Felipe Méndez López, Issa Gil Alfaro, Félix Gilberto Islas Ruz, Gloria Navarrete Floriano, Edith Guillen Salomón, Obdulia Texon Fernández, Silvia Cruz Duarte, Juan Carlos Romo Salazar, Claudia Elsa Pérez Ruiz, Sara de Jesús López Salas, Lizbeth Benítez Amaya, Javier Nahum Zapata Gallardo
OBJECTIVE: To determine the prevalence of medically unexplained physical symptoms and the characteristics and use of health services in a group of patients with medically unexplained physical symptoms and a group of patients with other illnesses. METHODS: This was a cross-sectional, retrospective and multicenter study. We included 1,043 patients over 18 years of age from 30 primary care units of a government health institution, in 11 states of Mexico, attended by 39 family physicians...
September 30, 2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27805027/tooth-demineralization-and-associated-factors-in-patients-on-fixed-orthodontic-treatment
#3
Elías Nahúm Salmerón-Valdés, Edith Lara-Carrillo, Carlo Eduardo Medina-Solís, Norma Leticia Robles-Bermeo, Rogelio José Scougall-Vilchis, Juan Fernando Casanova-Rosado, América Patricia Pontigo-Loyola, Miguel Ángel Fernández Barrera
Dental demineralization was determined in patients at three time points during fixed orthodontic treatment. A multiple cross-sectional study included 108 patients divided into three different groups: (1) beginning of orthodontic treatment; (2) one year into treatment; and (3) two years into treatment. Demineralization was estimated using a DIAGNOdent pen. We obtained data from multiple tooth-by-tooth demineralization readings combined with salivary pH and patients' oral hygienic and dietary behaviors. A t-test for independent samples and Spearman´s correlation were performed...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27796596/computerized-assessment-of-body-image-in-anorexia-nervosa-and-bulimia-nervosa-comparison-with-standardized-body-image-assessment-tool
#4
Asaf Caspi, Revital Amiaz, Noa Davidson, Efrat Czerniak, Eitan Gur, Nahum Kiryati, Daniel Harari, Miriam Furst, Daniel Stein
: Body image disturbances are a prominent feature of eating disorders (EDs). Our aim was to test and evaluate a computerized assessment of body image (CABI), to compare the body image disturbances in different ED types, and to assess the factors affecting body image. The body image of 22 individuals undergoing inpatient treatment with restricting anorexia nervosa (AN-R), 22 with binge/purge AN (AN-B/P), 20 with bulimia nervosa (BN), and 41 healthy controls was assessed using the Contour Drawing Rating Scale (CDRS), the CABI, which simulated the participants' self-image in different levels of weight changes, and the Eating Disorder Inventory-2-Body Dissatisfaction (EDI-2-BD) scale...
October 29, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27791186/proposing-a-mechanism-of-action-for-ataluren
#5
Nadeem Siddiqui, Nahum Sonenberg
No abstract text is available yet for this article.
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27791185/control-of-embryonic-stem-cell-self-renewal-and-differentiation-via-coordinated-alternative-splicing-and-translation-of-yy2
#6
Soroush Tahmasebi, Seyed Mehdi Jafarnejad, Ingrid S Tam, Thomas Gonatopoulos-Pournatzis, Edna Matta-Camacho, Yoshinori Tsukumo, Akiko Yanagiya, Wencheng Li, Yaser Atlasi, Maxime Caron, Ulrich Braunschweig, Dana Pearl, Arkady Khoutorsky, Christos G Gkogkas, Robert Nadon, Guillaume Bourque, Xiang-Jiao Yang, Bin Tian, Hendrik G Stunnenberg, Yojiro Yamanaka, Benjamin J Blencowe, Vincent Giguère, Nahum Sonenberg
Translational control of gene expression plays a key role during the early phases of embryonic development. Here we describe a transcriptional regulator of mouse embryonic stem cells (mESCs), Yin-yang 2 (YY2), that is controlled by the translation inhibitors, Eukaryotic initiation factor 4E-binding proteins (4E-BPs). YY2 plays a critical role in regulating mESC functions through control of key pluripotency factors, including Octamer-binding protein 4 (Oct4) and Estrogen-related receptor-β (Esrrb). Importantly, overexpression of YY2 directs the differentiation of mESCs into cardiovascular lineages...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27789387/evaluation-of-the-american-college-of-surgeons-national-surgical-quality-improvement-program-acs-nsqip-surgical-risk-calculator-in-gynecologic-oncology-patients-undergoing-minimally-invasive-surgery
#7
Deanna Teoh, Rebi Nahum Halloway, Jennifer Heim, Rachel Isaksson Vogel, Colleen Rivard
STUDY OBJECTIVE: To evaluate the ability of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) surgical risk calculator to predict discharge to post-acute care and perioperative complications in gynecologic oncology patients undergoing minimally invasive surgery (MIS). DESIGN: Retrospective chart review. DESIGN: Classification: II-1 SETTING: University hospital. PATIENTS: All patients undergoing MIS on the gynecologic oncology service from January 1, 2009 to December 30, 2013...
October 24, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27749446/tectonic-descemet-stripping-automated-endothelial-keratoplasty-for-the-management-of-sterile-corneal-perforations-in-decompensated-corneas
#8
Yoav Nahum, Irit Bahar, Massimo Busin
PURPOSE: To report the use of Descemet stripping automated endothelial keratoplasty (DSAEK) for treatment of sterile corneal perforations accompanying endothelial decompensation. METHODS: In this multicenter interventional case series, we reviewed the medical records of all tectonic DSAEK surgeries performed at Villa Serena-Villa Igea private Hospitals (Forlì, Italy) and Rabin Medical Center (Petach Tikva, Israel) between January 2014 and March 2016. RESULTS: Three patients with endothelial decompensation and sterile corneal perforation (n = 2) or impending corneal perforation (n = 1) underwent DSAEK between 2014 and 2015 at Villa Igea Hospital, Forlì, Italy, and Rabin Medical Center, Petach Tikva, Israel...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27740535/an-acknowledgement
#9
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27740534/%C3%A2-the-effect-of-ursodeoxycholic-acid-in-cystic-cholangiopathies
#10
Frank Lammert, Nahum Méndez-Sánchez
No abstract text is available yet for this article.
November 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27740517/%C3%A2-frequency-of-hepatitis-c-virus-infection-in-a-single-institution-in-mexico-with-a-focus-on-birth-cohort-population
#11
Héctor Baptista-González, Victor M Noffal-Nuño, Nahum Méndez-Sánchez
:  Background and rationale for the study. The generation of people born before 1965 is a high-risk group for developing chronic hepatitis C virus (HCV) infection. AIM: To report the experience on single institution of HCV infection under birth-cohort or baby boomers effect. MATERIAL AND METHODS: We used a cross-sectional design of consecutive subjects older than 18 years referred for serological evaluation for anti-HCV and detection of HCV RNA...
November 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27740513/%C3%A2-editorial
#12
Nahum Méndez-Sánchez
No abstract text is available yet for this article.
November 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27736019/computed-insight-into-a-peptide-inhibitor-preventing-the-induced-fit-mechanism-of-mura-enzyme-from-pseudomonas-aeruginosa
#13
Anderson H Lima, Alberto M Dos Santos, Cláudio Nahum Alves, Jerônimo Lameira
UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is one of the key enzymes involved in peptidoglycan biosynthesis. The peptide HESFWYLPHQSY (called PEP 1354) is an inhibitor of MurA with an IC50 value of 200 μm. In this article, we have used the FlexPepDock ab-initio protocol from the Rosetta program homology modeling and molecular dynamics simulations to analyze, for the first time, the interaction of the PEP 1354 peptide with MurA enzyme from Pseudomonas aeruginosa (MurA-PA). Our modeling results suggest that the peptide binds to the same active site as the natural substrate UDP-N-acetylglucosamine (UNAG)...
October 13, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27701073/a-continuum-of-mrnp-complexes-in-embryonic-microrna-mediated-silencing
#14
Edlyn Wu, Ajay A Vashisht, Clément Chapat, Mathieu N Flamand, Emiliano Cohen, Mihail Sarov, Yuval Tabach, Nahum Sonenberg, James Wohlschlegel, Thomas F Duchaine
MicroRNAs (miRNAs) impinge on the translation and stability of their target mRNAs, and play key roles in development, homeostasis and disease. The gene regulation mechanisms they instigate are largely mediated through the CCR4-NOT deadenylase complex, but the molecular events that occur on target mRNAs are poorly resolved. We observed a broad convergence of interactions of germ granule and P body mRNP components on AIN-1/GW182 and NTL-1/CNOT1 in Caenorhabditis elegans embryos. We show that the miRISC progressively matures on the target mRNA from a scanning form into an effector mRNP particle by sequentially recruiting the CCR4-NOT complex, decapping and decay, or germ granule proteins...
October 3, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27698114/eif2%C3%AE-phosphorylation-controls-thermal-nociception
#15
Arkady Khoutorsky, Robert E Sorge, Masha Prager-Khoutorsky, Sophie Anne Pawlowski, Geraldine Longo, Seyed Mehdi Jafarnejad, Soroush Tahmasebi, Loren J Martin, Mark H Pitcher, Christos G Gkogkas, Reza Sharif-Naeini, Alfredo Ribeiro-da-Silva, Charles W Bourque, Fernando Cervero, Jeffrey S Mogil, Nahum Sonenberg
A response to environmental stress is critical to alleviate cellular injury and maintain cellular homeostasis. Eukaryotic initiation factor 2 (eIF2) is a key integrator of cellular stress responses and an important regulator of mRNA translation. Diverse stress signals lead to the phosphorylation of the α subunit of eIF2 (Ser51), resulting in inhibition of global protein synthesis while promoting expression of proteins that mediate cell adaptation to stress. Here we report that eIF2α is instrumental in the control of noxious heat sensation...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27692920/twenty-fraction-prostate-radiotherapy-with-intra-prostatic-boost-results-of-a-pilot-study
#16
E Onjukka, J Uzan, C Baker, L Howard, A Nahum, I Syndikus
AIMS: For patients with high-risk, locally bulky prostate cancer, an intra-prostatic boost to tumour volumes (dose-painting) offers a risk-adapted dose escalation. We evaluated the feasibility of hypofractionated dose-painting radiotherapy and the associated toxicity. The possibility to streamline a radiobiologically optimised planning protocol was also investigated. MATERIALS AND METHODS: Twenty-eight patients were treated using a dose-painting approach; boost volumes were identified with functional magnetic resonance imaging scans...
September 29, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27663578/just-in-time-adaptive-interventions-jitais-in-mobile-health-key-components-and-design-principles-for-ongoing-health-behavior-support
#17
Inbal Nahum-Shani, Shawna N Smith, Bonnie J Spring, Linda M Collins, Katie Witkiewitz, Ambuj Tewari, Susan A Murphy
BACKGROUND: The just-in-time adaptive intervention (JITAI) is an intervention design aiming to provide the right type/amount of support, at the right time, by adapting to an individual's changing internal and contextual state. The availability of increasingly powerful mobile and sensing technologies underpins the use of JITAIs to support health behavior, as in such a setting an individual's state can change rapidly, unexpectedly, and in his/her natural environment. PURPOSE: Despite the increasing use and appeal of JITAIs, a major gap exists between the growing technological capabilities for delivering JITAIs and research on the development and evaluation of these interventions...
September 23, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27663353/characterization-of-irreversible-electroporation-ablation-with-a-validated-perfused-organ-model
#18
Suyashree Bhonsle, Mohammad Bonakdar, Robert E Neal, Charles Aardema, John L Robertson, Jonathon Howarth, Helen Kavnoudias, Kenneth R Thomson, S Nahum Goldberg, Rafael V Davalos
PURPOSE: To develop and validate a perfused organ model for characterizing ablations for irreversible electroporation (IRE)-based therapies. MATERIALS AND METHODS: Eight excised porcine livers were mechanically perfused with a modified phosphate-buffered saline solution to maintain viability during IRE ablation. IRE pulses were delivered using 2 monopolar electrodes over a range of parameters, including voltage (1,875-3,000 V), pulse length (70-100 µsec), number of pulses (50-600), electrode exposure (1...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27610009/mitochondrial-dna-from-hepatocytes-as-a-ligand-for-tlr9-drivers-of-nonalcoholic-steatohepatitis
#19
EDITORIAL
Priya Handa, Akhila Vemulakonda, Kris V Kowdley, Misael Uribe, Nahum Méndez-Sánchez
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis (NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH...
August 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27600101/effect-of-thermal-dose-on-heat-shock-protein-expression-after-radio-frequency-ablation-with-and-without-adjuvant-nanoparticle-chemotherapies
#20
Marwan Moussa, S Nahum Goldberg, Gaurav Kumar, Tatyana Levchenko, Vladimir Torchilin, Muneeb Ahmed
PURPOSE: The aim of this study was to evaluate the effect of different radio-frequency ablation (RFA) thermal doses on coagulation and heat shock protein (HSP) response with and without adjuvant nanotherapies. MATERIALS AND METHODS: First, Fischer rats were assigned to nine different thermal doses of hepatic RFA (50-90 °C, 2-20 min, three per group) or no treatment (n = 3). Next, five of these RF thermal doses were combined with liposomal-doxorubicin (Lipo-Dox, 1 mg intravenously) in R3230 breast tumours, or no tumour treatment (five per group)...
December 2016: International Journal of Hyperthermia
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