keyword
MENU ▼
Read by QxMD icon Read
search

Nahum

keyword
https://www.readbyqxmd.com/read/29782657/phantom-clinical-and-texture-indices-evaluation-and-optimization-of-a-penalized-likelihood-image-reconstruction-method-q-clear-on-a-bgo-pet-ct-scanner
#1
Gabriel Reynés-Llompart, Cristina Gámez-Cenzano, José Luís Vercher-Conejero, Aida Sabaté-Llobera, Nahúm Calvo-Malvar, Josep M Martí-Climent
INTRODUCTION: The aim of this study was to evaluate the behavior of a penalized-likelihood image reconstruction method (Q.Clear) under different count statistics and lesion-to-background ratios (LBR) on a BGO scanner, in order to obtain an optimum penalization factor (β value) to study and optimize for different acquisition protocols and clinical goals. METHODS: Both phantom and patient images were evaluated. Data from an image quality phantom were acquired using different Lesion-to-Background ratios and acquisition times...
May 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29757158/origins-of-the-changing-detector-response-in-small-megavoltage-photon-radiation-fields
#2
John D Fenwick, Georgios Georgiou, Carl Graham Rowbottom, Tracy S A Underwood, Sudhir Kumar, Alan E Nahum
Differences in detector response between measured small fields, fclin, and wider reference fields, fmsr, can be overcome by using correction factors or by designing detectors with field-size invariant responses. The changing response in small fields is caused by perturbations of the electron fluence within the detector sensitive volume. For solid-state detectors, it has recently been suggested that these perturbations might be caused by the non-water-equivalent effective atomic numbers Z of detector materials, rather than by their non-water-like densities...
May 14, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29754027/urinary-concentrations-of-phthalate-metabolites-bisphenols-and-personal-care-product-chemical-biomarkers-in-pregnant-women-in-israel
#3
Ronit Machtinger, Tamar Berman, Michal Adir, Abdallah Mansur, Andrea A Baccarelli, Catherine Racowsky, Antonia M Calafat, Russ Hauser, Ravit Nahum
Mounting evidence suggests possible adverse effects of intrauterine exposure to certain phenols and phthalates, two classes of endocrine disruptor chemicals, on the developing fetus, with consequences into later life. These findings have contributed to the replacement of some chemicals, such as di‑2‑ethylhexyl phthalate (DEHP) and bisphenol A (BPA), in consumer products. For the current study we quantified urinary concentrations of biomarkers of exposure among 50 pregnant women in Israel to several phthalates, bisphenols and personal care product chemicals, as well as DEHP and BPA alternatives...
May 10, 2018: Environment International
https://www.readbyqxmd.com/read/29735798/thrombosis-of-the-portal-venous-system-in-cirrhotic-vs-non-cirrhotic-patients
#4
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nancy E Aguilar-Olivos, Luis F Alva-López, Ericka Fajardo-Ordoñez, Ileana Acevedo-Silva, Patrick G Northup, Nicolas Intagliata, Stephen H Caldwell, Guadalupe Ponciano-Rodríguez, Xingshun Qi, Nahum Méndez-Sánchez
INTRODUCTION AND AIM: Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a predisposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that develop thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis. MATERIAL AND METHODS: We studied patients diagnosed with portal venous system thrombosis using contrast-enhanced computed tomography scan and doppler ultrasound at Medica Sur Hospital from 2012 to 2017...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29718228/revealing-the-puzzle-of-nonadherence-in-ibd-assembling-the-pieces
#5
Adi Eindor-Abarbanel, Timna Naftali, Nahum Ruhimovich, Ariella Bar-Gil Shitrit, Fabiana Sklerovsky-Benjaminov, Fred Konikoff, Shai Matalon, Haim Shirin, Yael Milgrom, Efrat Broide
Background: Adherence is generally associated with improved treatment outcomes in inflammatory bowel disease (IBD) patients. Different components of the patient profile have an impact on patient adherence. Capturing nonadherent patients by identifying modifiable risk factors in daily practice still remains a challenge. The objective of this study was to identify modifiable and nonmodifiable risk factors for nonadherence in IBD patients. Methods: Patients filled out questionnaires including demographic, clinical, and socioeconomic information and accessibility to gastrointestinal services...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718196/role-of-protein-phosphomannosylation-in-the-candida-tropicalis-macrophage-interaction
#6
Marco J Hernández-Chávez, Bernardo Franco, Diana M Clavijo-Giraldo, Nahúm V Hernández, Eine Estrada-Mata, Héctor Manuel Mora-Montes
Candida tropicalis is an opportunistic fungal pathogen responsible for mucosal and systemic infections. The cell wall is the initial contact point between a fungal cell and the host immune system, and mannoproteins are important components that play key roles when interacting with host cells. In C. albicans, mannans are modified by mannosyl-phosphate moieties, named phosphomannans, which can work as molecular scaffolds to synthesize β1,2-mannooligosaccharides, and MNN4 is a positive regulator of the phosphomannosylation pathway...
April 27, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29716790/neuronal-regulation-of-eif2%C3%AE-function-in-health-and-neurological-disorders
#7
REVIEW
Stephanie L Moon, Nahum Sonenberg, Roy Parker
A key site of translation control is the phosphorylation of the eukaryotic translation initiation factor 2α (eIF2α), which reduces the rate of GDP to GTP exchange by eIF2B, leading to altered translation. The extent of eIF2α phosphorylation within neurons can alter synaptic plasticity. Phosphorylation of eIF2α is triggered by four stress-responsive kinases, and as such eIF2α is often phosphorylated during neurological perturbations or disease. Moreover, in some cases decreasing eIF2α phosphorylation mitigates neurodegeneration, suggesting that this could be a therapeutic target...
April 28, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29713629/helminths-and-cancers-from-the-evolutionary-perspective
#8
REVIEW
Larissa L S Scholte, Marcelo A Pascoal-Xavier, Laila A Nahum
Helminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes ( Schistosoma haematobium, Schistosoma japonicum , and Schistosoma mansoni ) and liver flukes ( Clonorchis sinensis and Opisthorchis viverrini ) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29709618/an-action-video-game-for-the-treatment-of-amblyopia-in-children-a-feasibility-study
#9
Christina Gambacorta, Mor Nahum, Indu Vedamurthy, Jessica Bayliss, Josh Jordan, Daphne Bavelier, Dennis M Levi
The gold-standard treatment for childhood amblyopia remains patching or penalizing the fellow eye, resulting in an average of about a one line (0.1 logMAR) improvement in visual acuity following ≈ 120 hours of patching (Stewart, Moseley, Stephens, & Fielder, 2004; Stewart, Stephens, Fielder, Moseley, & Cooperative, 2007) in children 3 to 8 years old. However, compliance with patching and other treatment options is often poor. In contrast, fast-paced action video games can be highly engaging, and have been shown to yield broad-based improvements in vision and attention in adult amblyopia...
April 27, 2018: Vision Research
https://www.readbyqxmd.com/read/29690855/maternal-phthalate-and-personal-care-products-exposure-alters-extracellular-placental-mirna-profile-in-twin-pregnancies
#10
Jia Zhong, Andrea A Baccarelli, Abdallah Mansur, Michal Adir, Ravit Nahum, Russ Hauser, Valentina Bollati, Catherine Racowsky, Ronit Machtinger
Prenatal exposure to endocrine-disrupting chemicals (EDCs) exerts both short- and long-term adverse effects on the developing fetus. However, the mechanisms underlying these effects have yet to be uncovered. Maternal-fetal signaling is mediated in part by signaling molecules (eg, microRNAs [miRNAs]) contained in extracellular vesicles (EVs) that are released by the placenta into the maternal circulation. We investigated whether maternal exposure to the EDCs phthalates and personal care products alters the miRNA profile of placental-derived EVs circulating in maternal blood...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29682904/molecular-description-of-%C3%AE-keto-based-inhibitors-of-cruzain-with-activity-against-chagas-disease-combining-3d-qsar-studies-and-molecular-dynamics
#11
Ádria P B Saraiva, Ricardo M Miranda, Renan P P Valente, Jéssica O Araújo, Rutelene N B Souza, Clauber H S Costa, Amanda R S Oliveira, Michell O Almeida, Antonio F Figueiredo, João E V Ferreira, Cláudio Nahum Alves, Kathia M Honorio
In this work a group of α-keto-based inhibitors of the cruzain enzyme with anti-chagas activity was selected for a three-dimensional quantitative structure-activity relationship study (3D-QSAR) combined with molecular dynamics (MD). Firstly, statistical models based on Partial Least Square (PLS) regression were developed employing comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) descriptors. Validation parameters (q2 and r2 ) for the models were, respectively, 0...
April 22, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29679390/clinically-applicable-irreversible-electroporation-for-eradication-of-microorganisms
#12
Maya Korem, Nahum S Goldberg, Amos Cahan, Matan J Cohen, Isaac Nissenbaum, Allon E Moses
Irreversible electroporation (IRE) damages cell membranes and is used in medicine for non-thermal ablation of malignant tumors. Our aim was to evaluate the antimicrobial effect of IRE. The pathogenic microorganisms, S. aureus, S. pyogenes, E. coli, P. aeruginosa and C. albicans were subjected to IRE. Survival was measured as a function of voltage and the number of pulses applied. Combined use of IRE and oxacillin for eradication of S. aureus was also tested. Log10 reduction of microorganisms positively correlated with the number of applied pulses...
April 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29663565/risk-factors-for-early-invasive-fungal-infections-in-pediatric-liver-transplant-recipients
#13
Yehonatan Pasternak, Shiri Rubin, Efraim Bilavsky, Yael Mozer-Glassberg, Itzhak Levy, Elhanan Nahum, Eran Rom, Michael Gurevich, Haim Ben-Zvi, Liat Ashkenazi-Hoffnung
BACKGROUND: Invasive fungal infections (IFIs) post-liver transplantation are a frequent cause of morbidity and mortality;however, studies reporting on these infections in the pediatric population are scarce. OBJECTIVE: To investigate the incidence and risk factors of IFIs in pediatric liver transplant recipients during the early post-transplantation period (≤3 months). MATERIALS AND METHODS: Data were collected for all pediatric liver transplant recipients registered in a national transplantation center from 2004-2014...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29628297/evaluation-of-a-ct-guided-robotic-system-for-precise-percutaneous-needle-insertion
#14
Eliel Ben-David, Moran Shochat, Ido Roth, Isaac Nissenbaum, Jacob Sosna, S Nahum Goldberg
PURPOSE: To assess overall targeting accuracy for CT-guided needle insertion using prototype robotic system for common target sites. MATERIALS AND METHODS: Using CT guidance, metallic (2 × 1 mm) targets were embedded in retroperitoneum (n = 8), kidneys (n = 8), and liver (n = 14) of 8 Yorkshire pigs (55-65 kg). Bronchial bifurcations were targeted in the lung (n = 13). CT datasets were obtained for planning and controlled needle placement of commercially available 17- to 19-gauge needles (length 15-20 cm) using a small, patient-mounted, CT-guided robotic system with 5° of motion...
April 6, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29617653/removing-4e-bp-enables-synapses-to-refine-without-postsynaptic-activity
#15
Yumaine Chong, Natasha Saviuk, Brigitte Pie, Nathan Basisty, Ryan K Quinn, Birgit Schilling, Nahum Sonenberg, Ellis Cooper, A Pejmun Haghighi
Throughout the developing nervous system, considerable synaptic re-organization takes place as postsynaptic neurons extend dendrites and incoming axons refine their synapses, strengthening some and eliminating others. It is well accepted that these processes rely on synaptic activity; however, the mechanisms that lead to this developmental reorganization are not fully understood. Here, we explore the regulation of cap-dependent translation, a mechanism known to play a role in synaptic growth and plasticity...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29605040/outcomes-of-interval-appendectomy-in-comparison-with-appendectomy-for-acute-appendicitis
#16
Abbas Al-Kurd, Ido Mizrahi, Baha Siam, Amram Kupietzky, Nurith Hiller, Nahum Beglaibter, Ahmed Eid, Haggi Mazeh
BACKGROUND: Traditionally, patients treated conservatively for periappendiceal abscess or phlegmon would subsequently undergo interval appendectomy (IA); however, recent evidence has shed doubt on the necessity of this procedure. This study aimed to assess the outcomes of patients who underwent IA, in comparison with those operated acutely for appendicitis. MATERIALS AND METHODS: A retrospective analysis identified patients who underwent IA between 2000 and 2016...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29604043/optimizing-digital-integrated-care-via-micro-randomized-trials
#17
Ashley Walton, Billie Nahum-Shani, Lori Crosby, Predrag Klasnja, Susan Murphy
Mobile Health (mHealth) interventions are a promising tool in providing digitally mediated integrative care. They can extend care outside of the clinic by providing reminders to take medications, assisting in managing symptoms, and supporting healthy behaviors including physical activity, healthy eating and stress management. mHealth interventions can adapt the delivery of care across time in order to optimize treatment effectiveness. Yet there exists limited empirical evidence useful to the development of adaptive mHealth interventions...
March 31, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29582944/-percutaneous-treatment-of-small-renal-tumors-by-thermal-ablation
#18
Amitay Lorber, Nahum S Goldberg, Ofer N Gofrit, Dov Pode, Vladimir Yutkin, Ilan Gielchinsky, Mordechai Duvdevani, Ezekiel H Landau, Guy Hidas, Liat Apelbaum
INTRODUCTION: Kidney cancer accounts for approximately 2-3 % of all types of cancers. Renal tumors prevalence and especially the prevalence of small renal tumors, is on the rise. About half of the tumors currently diagnosed are smaller than 4 cm. Minimally invasive methods of radiofrequency ablation technology were recently developed for the treatment of small renal tumors and are characterized by reducing the surgical and anesthetic risk. The ablation is performed with a percutaneous approach guided by ultrasound, CT or MRI...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29555746/mtor-signaling-in-vip-neurons-regulates-circadian-clock-synchrony-and-olfaction
#19
Dong Liu, Adam Stowie, Nuria de Zavalia, Tanya Leise, Salil Saurav Pathak, Lester R Drewes, Alec J Davidson, Shimon Amir, Nahum Sonenberg, Ruifeng Cao
Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using the Cre-LoxP system, the mTOR gene was specifically knocked out in cells expressing Vip (vasoactive intestinal peptide), which represent a major population of interneurons widely distributed in the neocortex, suprachiasmatic nucleus (SCN), olfactory bulb (OB), and other brain regions...
April 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29552270/developing-optimized-adaptive-interventions-in-education
#20
Daniel Almirall, Connie Kasari, Daniel F McCaffrey, Inbal Nahum-Shani
Hedges (2018) encourages us to consider asking new scientific questions concerning the optimization of adaptive interventions in education. In this commentary, we have expanded on this (albeit briefly) by providing concrete examples of scientific questions and associated experimental designs to optimize adaptive interventions, and commenting on some of the ways such designs might challenge us to think differently. A great deal of methodological work remains to be done. For example, we have only begun to consider experimental design and analysis methods for developing "cluster-level adaptive interventions" (NeCamp, Kilbourne, & Almirall, 2017), or to extend methods for comparing the marginal mean trajectories between the adaptive interventions embedded in a SMART (Lu et al...
2018: Journal of Research on Educational Effectiveness
keyword
keyword
110214
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"