keyword
MENU ▼
Read by QxMD icon Read
search

Nahum

keyword
https://www.readbyqxmd.com/read/29144250/case-not-closed-prescription-errors-12-years-after-computerized-physician-order-entry-implementation
#1
Gili Kadmon, Michal Pinchover, Avichai Weissbach, Shirley Kogan Hazan, Elhanan Nahum
OBJECTIVE: To assess the prolonged impact of computerized physician order entry (CPOE) on medication prescription errors in pediatric intensive care patients. STUDY DESIGN: This observational study was conducted at a pediatric intensive care unit in which a CPOE (Metavision, iMDsoft, Israel) with a limited clinical decision support system was implemented between 2004 and 2007. Since then, no changes were made to the systems. We analyzed 2500 electronic prescriptions (1250 prescriptions from 2015 and 1250 prescriptions from 2016)...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29120329/in-memoriam-thomas-starzl-m-d-ph-d
#2
Burcin Taner, Nahum Méndez-Sánchez
No abstract text is available yet for this article.
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080343/bile-acids-in-nonalcoholic-fatty-liver-disease-new-concepts-and-therapeutic-advances
#3
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nahum Méndez-Sánchez
Nonalcoholic liver disease (NAFLD) is a major emerging health burden that is a common cause of illness and death worldwide. NAFLD can progress into nonalcoholic steatohepatitis (NASH) which is a severe form of liver disease characterized by inflammation and fibrosis. Further progression leads to cirrhosis, which predisposes patients to hepatocellular carcinoma or liver failure. The mechanism of the progression from simple steatosis to NASH is unclear. However, there are theories and hypothesis which support the link between disruption of the bile acids homeostasis and the progression of this disorder...
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080339/the-role-of-the-gut-microbiota-in-bile-acid-metabolism
#4
Oscar Ramírez-Pérez, Vania Cruz-Ramón, Paulina Chinchilla-López, Nahum Méndez-Sánchez
The gut microbiota has been considered a cornerstone of maintaining the health status of its human host because it not only facilitates harvesting of nutrients and energy from ingested food, but also produces numerous metabolites that can regulate host metabolism. One such class of metabolites, the bile acids, are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. These bioconversions modulate the signaling properties of bile acids through the nuclear farnesoid X receptor and the G protein-coupled membrane receptor 5, which regulate diverse metabolic pathways in the host...
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080337/bile-acids-in-health-and-disease-foreword
#5
Nahum Méndez-Sánchez
No abstract text is available yet for this article.
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080206/structural-dynamics-of-the-gw182-silencing-domain-including-its-rna-recognition-motif-rrm-revealed-by-hydrogen-deuterium-exchange-mass-spectrometry
#6
Maja K Cieplak-Rotowska, Krzysztof Tarnowski, Marcin Rubin, Marc R Fabian, Nahum Sonenberg, Michal Dadlez, Anna Niedzwiecka
The human GW182 protein plays an essential role in micro(mi)RNA-dependent gene silencing. miRNA silencing is mediated, in part, by a GW182 C-terminal region called the silencing domain, which interacts with the poly(A) binding protein and the CCR4-NOT deadenylase complex to repress protein synthesis. Structural studies of this GW182 fragment are challenging due to its predicted intrinsically disordered character, except for its RRM domain. However, detailed insights into the properties of proteins containing disordered regions can be provided by hydrogen-deuterium exchange mass spectrometry (HDX/MS)...
October 27, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29078415/profile-of-michael-n-hall-2017-albert-lasker-basic-medical-research-awardee-target-of-rapamycin-cell-growth-and-translational-control
#7
Nahum Sonenberg
No abstract text is available yet for this article.
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28992576/when-the-party-continues-impulsivity-and-the-effect-of-employment-on-young-adults-post-college-alcohol-use
#8
I M Geisner, J Koopmann, P Bamberger, M Wang, M E Larimer, I Nahum-Shani, S Bacharach
BACKGROUND: The transition from college to work is both an exciting and potentially high risk time for young adults. As students transition from academic settings to full-time employment, they must navigate new social demands, work demands, and adjust their drinking behaviors accordingly. Research has shown that there are both protective factors and risk factors associated with starting a new job when it comes to alcohol use, and individual differences can moderate these factors. METHOD: 1361 students were recruited from 4 geographically diverse universities and followed 1month pre- and 1month post-graduation...
September 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28981300/correction-to-bamberger-et-al-2017
#9
(no author information available yet)
Reports an error in "Does College Alcohol Consumption Impact Employment Upon Graduation? Findings From a Prospective Study" by Peter A. Bamberger, Jaclyn Koopmann, Mo Wang, Mary Larimer, Inbal Nahum-Shani, Irene Geisner and Samuel B. Bacharach (Journal of Applied Psychology, Advanced Online Publication, Aug 24, 2017, np). In the original article, the authors incorrectly used the term "probability" instead of the term "odds" when relating to the impact of drinking in college on post-graduation employment. The abstract should note "a roughly 10% reduction in the odds ...
October 5, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28960184/fragile-x-syndrome
#10
REVIEW
Randi J Hagerman, Elizabeth Berry-Kravis, Heather Cody Hazlett, Donald B Bailey, Herve Moine, R Frank Kooy, Flora Tassone, Ilse Gantois, Nahum Sonenberg, Jean Louis Mandel, Paul J Hagerman
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism spectrum disorder, and patients can present with severe behavioural alterations, including hyperactivity, impulsivity and anxiety, in addition to poor language development and seizures. FXS is a trinucleotide repeat disorder, in which >200 repeats of the CGG motif in FMR1 leads to silencing of the gene and the consequent loss of its product, fragile X mental retardation 1 protein (FMRP). FMRP has a central role in gene expression and regulates the translation of potentially hundreds of mRNAs, many of which are involved in the development and maintenance of neuronal synaptic connections...
September 29, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28954307/in-vitro-effects-of-the-specific-mitochondrial-tspo-ligand-ro5-4864-in-cultured-human-osteoblasts
#11
Rosenberg Nahum, Rosenberg Orit, Weizman Abraham, Veenman Leo, Gavish Moshe
The 18 kDa mitochondrial translocator protein (TSPO) ligands (10 µM), e. g., protoporphyrin IX, PK 11195 and FGIN-1-27, have different effects on metabolism and protein expression in human osteoblasts. In this study, we investigated the archetypical TSPO specific ligand Ro5-4864 (10 µM) effect in primary osteoblasts in culture aiming to further understand the TSPO role in these mature metabolically active cells.We found that following exposure to Ro5-4864, cellular [(18)F]-FDG incorporation and ATP content were reduced by 48% (p<0...
September 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28940109/effect-of-extracellular-tyrosinase-on-the-expression-level-of-p450-fpr-and-fdx-and-ortho-hydroxylation-of-daidzein-in-streptomyces-avermitilis
#12
Bishnu Prasad Pandey, Nahum Lee, Byung-Gee Kim
We have reported that the expression of CYP105D7 in Streptomyces avermitilis produces 112.5 mg L(-1) of 7,3',4'-trihydroxyisoflavone (3'ODI) in 15 h of the reaction time, when 7,4'-dihydroxyisoflavone (daidzein) is used as a substrate. Although production is significant, rapid degradation of 3'ODI after 15 h was observed in a whole-cell biotransformation system, suggesting the further modification of 3'ODI by endogenous enzymes. In this present study, the effect of deletion of extracellular tyrosinase (melC2) in S...
September 22, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28919888/the-sporothrix-schenckii-gene-encoding-for-the-ribosomal-protein-l6-has-constitutive-and-stable-expression-and-works-as-an-endogenous-control-in-gene-expression-analysis
#13
Elías Trujillo-Esquivel, José A Martínez-Álvarez, Diana M Clavijo-Giraldo, Nahúm V Hernández, Alberto Flores-Martínez, Patricia Ponce-Noyola, Héctor M Mora-Montes
Sporothrix schenckii is one of the causative agents of sporotrichosis, a worldwide-distributed mycosis that affects humans and other mammals. The interest in basic and clinical features of this organism has significantly increased in the last years, yet little progress in molecular aspects has been reported. Gene expression analysis is a set of powerful tools that helps to assess the cell response to changes in the extracellular environment, the genetic networks controlling metabolic pathways, and the adaptation to different growth conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28918902/mtor-controls-mitochondrial-dynamics-and-cell-survival-via-mtfp1
#14
Masahiro Morita, Julien Prudent, Kaustuv Basu, Vanessa Goyon, Sakie Katsumura, Laura Hulea, Dana Pearl, Nadeem Siddiqui, Stefan Strack, Shawn McGuirk, Julie St-Pierre, Ola Larsson, Ivan Topisirovic, Hojatollah Vali, Heidi M McBride, John J Bergeron, Nahum Sonenberg
The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well understood. Here, we demonstrate that the nutrient-sensing mechanistic/mammalian target of rapamycin complex 1 (mTORC1) stimulates translation of mitochondrial fission process 1 (MTFP1) to control mitochondrial fission and apoptosis. Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1)...
September 21, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28881582/metformin-requires-4e-bps-to-induce-apoptosis-and-repress-translation-of-mcl-1-in-hepatocellular-carcinoma-cells
#15
Mamatha Bhat, Akiko Yanagiya, Tyson Graber, Nataliya Razumilava, Steve Bronk, Domenick Zammit, Yunhao Zhao, Chadi Zakaria, Peter Metrakos, Michael Pollak, Nahum Sonenberg, Gregory Gores, Maritza Jaramillo, Masahiro Morita, Tommy Alain
Metformin inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which is frequently upregulated in hepatocellular carcinoma (HCC). Metformin has also been shown to induce apoptosis in this cancer. Here, we investigate whether metformin-induced apoptosis in HCC is mediated by the downstream mTORC1 effectors eukaryotic initiation factor 4E and (eIF4E)-binding proteins (4E-BPs). Further, we ask whether changes in 4E-BPs activity during metformin treatment negatively regulate translation of the anti-apoptotic myeloid cell leukemia 1 (Mcl-1) mRNA...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880787/targeting-stat3-to-suppress-systemic-pro-oncogenic-effects-from-hepatic-radiofrequency-ablation
#16
Gaurav Kumar, S Nahum Goldberg, Svetlana Gourevitch, Tatyana Levchenko, Vladimir Torchilin, Eithan Galun, Muneeb Ahmed
Purpose To (a) identify key expressed genes in the periablational rim after radiofrequency ablation (RFA) and their role in driving the stimulation of distant tumor growth and (b) use adjuvant drug therapies to block key identified mediator(s) to suppress off-target tumorigenic effects of hepatic RFA. Materials and Methods This institutional animal care and use committee-approved study was performed in C57BL6 mice (n = 20) and F344 rats (n = 124). First, gene expression analysis was performed in mice after hepatic RFA or sham procedure; mice were sacrificed 24 hours to 7 days after treatment...
September 6, 2017: Radiology
https://www.readbyqxmd.com/read/28866952/optical-flow-and-image-segmentation-analysis-for-noninvasive-precise-mapping-of-microwave-thermal-ablation-in-x-ray-ct-scans-ex-vivo-study
#17
Omri Ziv, S Nahum Goldberg, Yitzhak Nissenbaum, Jacob Sosna, Noam Weiss, Haim Azhari
PURPOSE: To develop image processing algorithms for noninvasive mapping of microwave thermal ablation using X-ray CT. METHODS: Ten specimens of bovine liver were subjected to microwave ablation (20-80W, 8 minutes) while scanned by X-ray CT at 5 seconds intervals. Specimens were cut and manually traced by two observers. Two algorithms were developed and implemented to map the ablation zone. The first algorithm utilizes images segmentation of Hounsfield units changes (ISHU)...
September 3, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28836800/does-college-alcohol-consumption-impact-employment-upon-graduation-findings-from-a-prospective-study
#18
Peter A Bamberger, Jaclyn Koopmann, Mo Wang, Mary Larimer, Inbal Nahum-Shani, Irene Geisner, Samuel B Bacharach
Although scholars have extensively studied the impact of academic and vocational factors on college students' employment upon graduation, we still know little as to how students' health-related behaviors influence such outcomes. Focusing on student alcohol use as a widely prevalent, health-related behavior, in the current study, we examined the employment implications of student drinking behavior. Drawing from literature examining the productivity effects of drinking and research on job search, we posited that modal quantity and frequency of alcohol consumption, as well as the frequency of heavy episodic drinking (HED) adversely impact the probability of employment upon graduation...
August 24, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28836204/detection-of-infiltrating-mast-cells-using-a-modified-toluidine-blue-staining
#19
Nahum Puebla-Osorio, Seri N E Sarchio, Stephen E Ullrich, Scott N Byrne
Mast cells are part of the immune system and characteristically contain histamine- and heparin-rich basophilic granules. While these cells are usually associated with allergy and anaphylaxis, they also promote wound healing and angiogenesis and confer protection against pathogens. The presence of these cells is sometimes indicative of a poor prognosis, especially in skin cancer, pancreatic cancer, and lymphoma. Toluidine blue staining of acid-fast granules is an established method for the identification and quantification of mast cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28829128/unraveling-the-addition-elimination-mechanism-of-epsp-synthase-through-computer-modeling
#20
Alberto M Dos Santos, Anderson H Lima, Cláudio Nahum Alves, Jerônimo Lameira
Enolpyruvyl transfer from phosphoenolpyruvate (PEP) to the hydroxyl group of shikimate-5-OH-3-phosphate (S3P) is catalyzed by 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase in a reaction that involves breaking the C-O bond of PEP. Catalysis involves an addition-elimination mechanism with the formation of a tetrahedral intermediate (THI). Experiments have elucidated the mechanism of THI formation and breakdown. However, the catalytic action of EPSP synthase and the individual roles of catalytic residues Asp313 and Glu341 remains unclear...
September 8, 2017: Journal of Physical Chemistry. B
keyword
keyword
110214
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"