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https://www.readbyqxmd.com/read/29323538/clinical-characteristics-and-outcomes-of-traditional-chinese-medicine-induced-liver-injury-a-systematic-review
#1
Ran Wang, Xingshun Qi, Eric Yoshida, Nahum Mendez-Sanchez, Rolf Teschke, Mingyu Sun, Xu Liu, Chunping Su, Jiao Deng, Han Deng, Feifei Hou, Xiaozhong Guo
BACKGROUNDS: Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated. AIMS: This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI). METHODS: China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched...
January 11, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29320701/aminoacylation-of-proteins-new-targets-for-the-old-arsenal
#2
Seyed Mehdi Jafarnejad, Sung-Hoon Kim, Nahum Sonenberg
Besides charging tRNAs with their cognate amino acids, aminoacyl-tRNA synthetases (ARSs) are involved in a plethora of non-canonical functions, including development, immune response, and angiogenesis. In this issue of Cell Metabolism, He et al. (2018) report a novel biochemical function of ARSs: posttranslational addition of amino acids to lysine residues in proteins.
January 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29311406/the-changing-face-of-the-diagnosis-of-chronic-and-malignant-liver-diseases-potential-new-biomarkers
#3
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Xingshun Qi, Nahum Méndez-Sánchez
The early diagnosis of primary sclerosing cholangitis, hepatocellular carcinoma, and cholangiocarcinoma is often challenging. In a recent study in 134 patients (Arbelaiz, Hepatology 2017; 66:1125-1143), it was reported that specific proteins found in serum extracellular vesicles of patients with primary sclerosing cholangitis, hepatocellular carcinoma,orcholangiocarcinomamay be useful as noninvasive diagnostic and prognostic tools. This current article critically appraises this study.
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29306610/hypoglycemia-during-oral-glucose-tolerance-test-among-post-bariatric-surgery-pregnant-patients-incidence-and-perinatal-significance
#4
Amihai Rottenstreich, Ram Elazary, Yossef Ezra, Geffen Kleinstern, Nahum Beglaibter, Uriel Elchalal
BACKGROUND: While hypoglycemia during an oral glucose tolerance test (OGTT) has been shown to occur in a considerable portion of nonpregnant post-bariatric surgery (BS) patients, its incidence among pregnant post-BS patients evaluated for gestational diabetes has only been sparsely studied. OBJECTIVES: We investigated OGTT results and pregnancy outcomes in pregnant women who underwent 3 types of bariatric procedures before pregnancy. SETTING: A university hospital...
December 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29302809/preeclampsia-acts-differently-in-in-vitro-fertilization-versus-spontaneous-twins
#5
Rania Okby, Avi Harlev, Kira Nahum Sacks, Ruslan Sergienko, Eyal Sheiner
OBJECTIVE: To investigate risk factors and pregnancy outcome of spontaneous vs in-vitro fertilization (IVF) twins complicated with preeclampsia. STUDY DESIGN: A retrospective population-based cohort study comparing maternal and neonatal outcome in IVF vs spontaneously conceived twins was conducted. Deliveries occurred in a tertiary medical center between the years 1988 and 2010. Women who conceived after ovulation induction and those with chronic hypertension were excluded from the study...
January 4, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29276451/center-of-excellence-for-mobile-sensor-data-to-knowledge-md2k
#6
Santosh Kumar, Gregory Abowd, William T Abraham, Mustafa al'Absi, Duen Horng Polo Chau, Emre Ertin, Deborah Estrin, Deepak Ganesan, Timothy Hnat, Syed Monowar Hossain, Zachary Ives, Jacqueline Kerr, Benjamin M Marlin, Susan Murphy, James M Rehg, Inbal Nahum-Shani, Vivek Shetty, Ida Sim, Bonnie Spring, Mani Srivastava, Dave Wetter
No abstract text is available yet for this article.
April 2017: IEEE Pervasive Computing
https://www.readbyqxmd.com/read/29258955/evaluation-of-toxicological-endpoints-in-female-zebrafish-after-bisphenol-a-exposure
#7
Ana M Molina, Nieves Abril, Noelia Morales-Prieto, José G Monterde, Antonio J Lora, Nahúm Ayala, Rosario Moyano
Given the importance of bisphenol A (BPA) as a xenoestrogen and its potential effects on human and animal health, we evaluated BPA exposure's short-term effects on follicular development, yolk protein vitellogenin (VTG) production and aromatase expression in female zebrafish. Histological modifications were observed along with increased presence of atretic follicles. Whole-body VTG concentration increased with the dose of BPA exposure. In contrast, expression of Cyp19a mRNA in the ovaries of BPA-exposed fish exhibited an apparent non-monotonic response curve, marked by downregulation at 1 μg/L BPA, upregulation at 10 μg/L BPA, and a return to downregulation at 100 μg/L BPA and higher doses...
December 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29240416/electrical-properties-and-oxygen-stoichiometry-of-ba1-xsrxtio3-%C3%AE-ceramics
#8
Mei Guo, Nahum Masó, Yang Liu, Anthony R West
Ba1-xSrxTiO3 solid solutions prepared by a solid-state reaction in air at 1200-1400 °C, followed by slow cooling to room temperature at the end of the reaction, were essentially oxygen-stoichiometric and p-type. Their conductivity increased reversibly when either p(O2) in the surrounding atmosphere was increased or a dc bias as small as 1 V was applied across the samples. The enhanced p-type conductivity is attributed to the creation of mobile holes on underbonded oxide ions. The same samples quenched from >∼1400 °C were increasingly oxygen deficient and n-type...
December 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29235737/long-term-survival-of-discharged-patients-admitted-to-intensive-coronary-care-unit-after-out-of-hospital-cardiac-arrest
#9
Dante Antonelli, Ofir Koren, Menachem Nahir, Ehud Rozner, Nahum A Freedberg, Yoav Turgeman
BACKGROUND: Survival of patients who were discharged from the hospital following out-of-hospital cardiac arrest (OHCA) has not been well defined. OBJECTIVES: To verify predictor variables for prognosis of patients following OHCA who survived hospitalization. METHODS: We retrospectively reviewed clinical, demographic, and outcome data of consecutive patients who were hospitalized from January 1, 2009, through December 31, 2014, into the intensive coronary care unit (ICCU) after aborted OHCA and discharged alive...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29204778/conversion-of-laparoscopic-adjustable-gastric-banding-to-gastric-bypass-a-comparison-to-primary-gastric-bypass
#10
Abbas Al-Kurd, Ronit Grinbaum, Ala'a Abubeih, Baha Siam, Muhammad Ghanem, Haggi Mazeh, Ido Mizrahi, Nahum Beglaibter
INTRODUCTION: Laparoscopic adjustable gastric banding (LAGB) has a considerable failure rate. Laparoscopic Roux-en-Y gastric bypass (LRYGB) is one of the rescue options. This study aims to compare the complication rates and outcomes between LAGB converted to LRYGB and primary LRYGB. MATERIALS AND METHODS: A retrospective analysis was performed in all patients converted from LAGB to LRYGB between January 2007 and March 2017. This group was compared to a matched cohort of primary LRYGB patients operated during the same period...
December 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29189394/ischemic-stroke-in-liver-cirrhosis-epidemiology-risk-factors-and-in-hospital-outcomes
#11
Xintong Zhang, Xingshun Qi, Eric M Yoshida, Nahum Méndez-Sánchez, Feifei Hou, Han Deng, Xiaoxi Wang, Jing Qiu, Chao He, Shuang Wang, Xiaozhong Guo
BACKGROUND AND AIMS: Patients with cirrhosis are reportedly more prone to develop hemorrhagic stroke, thereby increasing the risk of death. However, the effect of ischemic stroke on liver diseases remains unclear. In addition, few studies have explored the risk factors for ischemic stroke in patients with liver cirrhosis. Our study aimed to explore the epidemiology, risk factors, and in-hospital outcomes of ischemic stroke in a large cohort of hospitalized patients with cirrhosis. PATIENTS AND METHODS: In this single-center observational study, we retrospectively reviewed the medical records of patients with liver cirrhosis admitted to our hospital from January 2011 to June 2014...
February 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29169064/eukaryotic-initiation-factor-4f-sidestepping-resistance-mechanisms-arising-from-expression-heterogeneity
#12
REVIEW
Jennifer Chu, Santiago Ramon Y Cajal, Nahum Sonenberg, Jerry Pelletier
There is enormous diversity in the genetic makeup and gene expression profiles between and within tumors. This heterogeneity leads to phenotypic variation and is a major mechanism of resistance to molecular targeted therapies. Here we describe a conceptual framework for targeting eukaryotic initiation factor (eIF) 4F in cancer-an essential complex that drives and promotes multiple Cancer Hallmarks. The unique nature of eIF4F and its druggability bypasses several of the heterogeneity issues that plague molecular targeted drugs developed for cancer therapy...
November 20, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29167666/first-year-of-israeli-newborn-screening-for-severe-combined-immunodeficiency-clinical-achievements-and-insights
#13
Erez Rechavi, Atar Lev, Amos J Simon, Tali Stauber, Suha Daas, Talia Saraf-Levy, Arnon Broides, Amit Nahum, Nufar Marcus, Suhair Hanna, Polina Stepensky, Ori Toker, Ilan Dalal, Amos Etzioni, Shlomo Almashanu, Raz Somech
Severe combined immunodeficiency (SCID), the most severe form of T cell immunodeficiency, is detectable through quantification of T cell receptor excision circles (TRECs) in dried blood spots obtained at birth. Herein, we describe the results of the first year of the Israeli SCID newborn screening (NBS) program. This important, life-saving screening test is available at no cost for every newborn in Israel. Eight SCID patients were diagnosed through the NBS program in its first year, revealing an incidence of 1:22,500 births in the Israeli population...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163088/simultaneous-reality-filtering-and-encoding-of-thoughts-the-substrate-for-distinguishing-between-memories-of-real-events-and-imaginations
#14
Raphaël Thézé, Aurélie L Manuel, Louis Nahum, Adrian G Guggisberg, Armin Schnider
Any thought, whether it refers to the present moment or reflects an imagination, is again encoded as a new memory trace. Orbitofrontal reality filtering (ORFi) denotes an on-line mechanism which verifies whether upcoming thoughts relate to ongoing reality or not. Its failure induces reality confusion with confabulations and disorientation. If the result of this process were simultaneously encoded, it would easily explain later distinction between memories relating to a past reality and memories relating to imagination, a faculty called reality monitoring...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29145979/current-ultrasound-application-in-the-foot-and-ankle
#15
REVIEW
Nahum Michael Beard, Robert Patrick Gousse
This article is a comprehensive review of the current utilizations of ultrasound in the treatment of orthopedic conditions of the foot and ankle. It reviews the diagnostic and interventional applications to commonly encountered lower-extremity ailments, including plantar fasciosis, tendinosis, and peripheral nerve disorders. It also outlines minimally invasive ultrasound-guided procedures and emerging therapies as alternatives to current treatments. These emerging therapies can be used to assist surgeons and provide options for patients needing intervention...
January 2018: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/29144250/case-not-closed-prescription-errors-12-years-after-computerized-physician-order-entry-implementation
#16
Gili Kadmon, Michal Pinchover, Avichai Weissbach, Shirley Kogan Hazan, Elhanan Nahum
OBJECTIVE: To assess the prolonged impact of computerized physician order entry (CPOE) on medication prescription errors in pediatric intensive care patients. STUDY DESIGN: This observational study was conducted at a pediatric intensive care unit in which a CPOE (Metavision, iMDsoft, Israel) with a limited clinical decision support system was implemented between 2004 and 2007. Since then, no changes were made to the systems. We analyzed 2500 electronic prescriptions (1250 prescriptions from 2015 and 1250 prescriptions from 2016)...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29120329/in-memoriam-thomas-starzl-m-d-ph-d
#17
Burcin Taner, Nahum Méndez-Sánchez
No abstract text is available yet for this article.
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080343/bile-acids-in-nonalcoholic-fatty-liver-disease-new-concepts-and-therapeutic-advances
#18
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nahum Méndez-Sánchez
Nonalcoholic liver disease (NAFLD) is a major emerging health burden that is a common cause of illness and death worldwide. NAFLD can progress into nonalcoholic steatohepatitis (NASH) which is a severe form of liver disease characterized by inflammation and fibrosis. Further progression leads to cirrhosis, which predisposes patients to hepatocellular carcinoma or liver failure. The mechanism of the progression from simple steatosis to NASH is unclear. However, there are theories and hypothesis which support the link between disruption of the bile acids homeostasis and the progression of this disorder...
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080339/the-role-of-the-gut-microbiota-in-bile-acid-metabolism
#19
Oscar Ramírez-Pérez, Vania Cruz-Ramón, Paulina Chinchilla-López, Nahum Méndez-Sánchez
The gut microbiota has been considered a cornerstone of maintaining the health status of its human host because it not only facilitates harvesting of nutrients and energy from ingested food, but also produces numerous metabolites that can regulate host metabolism. One such class of metabolites, the bile acids, are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. These bioconversions modulate the signaling properties of bile acids through the nuclear farnesoid X receptor and the G protein-coupled membrane receptor 5, which regulate diverse metabolic pathways in the host...
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29080337/bile-acids-in-health-and-disease-foreword
#20
Nahum Méndez-Sánchez
No abstract text is available yet for this article.
October 28, 2017: Annals of Hepatology
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