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Nahum Méndez-Sánchez, Xingshun Qi
No abstract text is available yet for this article.
August 2018: Annals of Translational Medicine
Kira Nahum Sacks, Michael Friger, Ilana Shoham-Vardi, Efrat Spiegel, Ruslan Sergienko, Daniella Landau, Eyal Sheiner
INTRODUCTION: Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Regarding the offspring, little is known about the long-term complications. The objective of the current study is to assess whether in utero exposure to preeclampsia increases the risk of long-term cardiovascular morbidity in the offspring. MATERIALS AND METHODS: A population-based cohort study compared the incidence of cardiovascular disease between singletons exposed and unexposed to preeclampsia...
July 2018: Pregnancy Hypertension
Roman Nevzorov, Ilan Goldenberg, Yuval Konstantino, Gregory Golovchiner, Boris Strasberg, Mahmoud Souleiman, Vladimir Khalameizer, Shlomit Ben-Zvi, Ron Sela, Shimon Rosenheck, Nahum A Freedberg, Michael Geist, Michal Einhorn Cohen, Tal Cohen, Nir Shlomo Msc, Natalie Gabrielov, Diklah Geva, Michael Glikson, Moti Haim
Life expectancy of >1 year is usually a contraindication for ICD implantation.The aim was to identify patients at risk of death during the first year after implantation METHODS AND RESULTS: Data derived from a prospective Israeli ICD Registry. Two groups of patients were compared: those who died and those who were alive 1-year after ICD implantation. Factors associated with 1-year mortality were identified on a derivation cohort. A risk score was established and validated. A total of 2617 patients have completed 1 year of follow up after ICD or CRTD implantation...
August 31, 2018: Journal of Cardiovascular Electrophysiology
Marco Solbiati, Katia M Passera, Alessandro Rotilio, Francesco Oliva, Ilaria Marre, S Nahum Goldberg, Tiziana Ierace, Luigi Solbiati
Background: To assess the feasibility of a novel system that uses augmented reality to guide interventional oncology procedures. Methods: This study was conducted in accordance to the guidelines of the local institutional review boards. Evaluation of an augmented reality system based upon a tablet, a needle handle and a set of markers was performed in three experimental models. Initially, a male anthropomorphic trunk phantom equipped with five polyvinyl chloride bars (two of 16 cm in length and 3 cm in diameter and four of 45, 30 or 20 cm in length and 2 cm in diameter) was used to study the accuracy of the system without respiratory motion or tissue compression...
December 2018: European radiology experimental
Chadi Zakaria, Polen Sean, Huy-Dung Hoang, Louis-Phillipe Leroux, Margaret Watson, Samuel Tekeste Workenhe, Jaclyn Hearnden, Dana Pearl, Vinh Tai Truong, Nathaniel Robichaud, Akiko Yanagiya, Soroush Tahmasebi, Seyed Mehdi Jafarnejad, Jian-Jun Jia, Adrian Pelin, Jean-Simon Diallo, Fabrice Le Boeuf, John Cameron Bell, Karen Louise Mossman, Tyson Ernst Graber, Maritza Jaramillo, Nahum Sonenberg, Tommy Alain
Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within tumours is limiting. Rapamycin can stimulate HSV1 replication in cancer cells, but active-site dual mTORC1 and mTORC2 (mammalian target of rapamycin complex 1 and 2) inhibitors (asTORi) were shown to suppress the virus in normal cells. Surprisingly, using the infected cell protein 0 (ICP0)-deleted HSV1 (HSV1-dICP0), we found that asTORi markedly augment infection in cancer cells and a mouse mammary cancer xenograft...
August 2018: PLoS Pathogens
Ari Nahum
No abstract text is available yet for this article.
August 2018: Journal of Palliative Medicine
Jonathan Kass, Amir Sherkat, Elmer Nahum, Matthew Hartman
The following case report demonstrates an unusual case of a patient with multiple intravascular iatrogenic foreign bodies. An inferior vena cava filter was identified in the abdominal aorta, and multiple hydrophilic wire fragments were found in the pulmonary circulation. After describing the management of this patient, we discuss how radiologists can best distinguish between various intravascular iatrogenic foreign bodies. Determining the type of catheter or wire within the patient can not only establish the chronicity of the finding, but can determine whether or not endovascular retrieval is recommended, and by what method...
July 21, 2018: Current Problems in Diagnostic Radiology
Itay E Gabbay, Yoav Nahum, Yiftach Yassur, Inbal Avisar
OBJECTIVE: To assess the use of lacrimal stenting for chronic papillary conjunctivitis associated with epiphora in young adults with little or no atopic background. METHODS: A retrospective interventional case series of 21 consecutive patients (36 eyes) treated for epiphora and chronic papillary conjunctivitis at a tertiary university-affiliated medical center between January 2014 and August 2015 by the same oculoplastic surgeon (I.A). Data were collected by retrospective file review...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Rodrigo Correa, Jesús Arenas, Gonzalo Montoya, Lía Hoz, Sonia López, Fabiola Salgado, Rita Arroyo, Nahúm Salmeron, Enrique Romo, Margarita Zeichner-David, Higinio Arzate
The use of recombinant proteins has revolutionized the development of biologic pharmaceuticals; however, they are not free of complications. Some have very high molecular weight, some demonstrate in vivo instability, and the high cost of producing them remains a major problem. On the other hand, it has been shown that peptides derived from active domains keep their biologic activity and can trigger events, such as osteogenesis and bone regeneration. Small peptides are advantageous because of their ease of synthesis and handling and their low immunogenic activity...
August 16, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Pevni Dmitry, Aizer Zahi, Mohr Rephael, Nesher Nahum, Kremer Amir, Paz Yosef, Taih Nadav, Ben-Gal Yanai
OBJECTIVES: Bilateral internal thoracic artery (ITA) grafting is associated with improved survival. However, potential survival benefit of using two ITA`s in patients with chronic lung disease (CLD) is questionable due to their increased risk of sternal wound infection (SWI) compared to operations incorporating single ITA (SITA). The purpose of this study is to compare early and long-term outcome of bilateral internal thoracic artery (BITA) grafting to that of grafting with single internal thoracic grafts and vein grafts or radial artery (SITA) in CLD patients with multi-vessels coronary disease...
2018: PloS One
Michael Green, Edith M Marom, Eli Konen, Nahum Kiryati, Arnaldo Mayer
CCTA has become an important tool for coronary arteries assessment in low and medium risk patients. However, it exposes the patient to significant radiation doses, resulting from high image quality requirements and acquisitions at multiple cardiac phases. For widespread use of CCTA for coronary assessment, significant reduction of radiation exposure with minimal image quality loss is still needed. A neural denoising scheme, relying on a fully convolutional neural network (FCNN) architecture, is developed and applied to noisy CCTA...
July 29, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
David Lichtstein, Asher Ilani, Haim Rosen, Noa Horesh, Shiv Vardan Singh, Nahum Buzaglo, Anastasia Hodes
Bipolar disorder (BD) is a severe and common chronic mental illness characterized by recurrent mood swings between depression and mania. The biological basis of the disease is poorly understood and its treatment is unsatisfactory. Although in past decades the "monoamine hypothesis" has dominated our understanding of both the pathophysiology of depressive disorders and the action of pharmacological treatments, recent studies focus on the involvement of additional neurotransmitters/neuromodulators systems and cellular processes in BD...
August 7, 2018: International Journal of Molecular Sciences
Soroush Tahmasebi, Nahum Sonenberg, John W B Hershey, Michael B Mathews
Protein synthesis and its regulation are central to all known forms of life and impinge on biological arenas as varied as agriculture, biotechnology, and medicine. Otherwise known as translation and translational control, these processes have been investigated with increasing intensity since the middle of the 20th century, and in increasing depth with advances in molecular and cell biology. We review the origins of the field, focusing on the underlying concepts and early studies of the cellular machinery and mechanisms involved...
August 6, 2018: Cold Spring Harbor Perspectives in Biology
Raphaël Thézé, Aurélie L Manuel, Elena Pedrazzini, Fabrice Chantraine, Maria Cristina Patru, Louis Nahum, Adrian G Guggisberg, Armin Schnider
BACKGROUND: A false sense of reality is a characteristic of schizophrenia spectrum disorders (SSD). Reality confusion may also emanate from posterior orbitofrontal cortex (OFC) lesions, as evident in confabulations that patients act upon and disorientation. This confusion can be measured by repeated runs of a continuous recognition task (CRT): patients increase their false positive rate from the second run on, failing to realize that an item is not a repetition within the current run...
July 26, 2018: Schizophrenia Research
Sean C Murphy, Andrew S Ishizuka, Zachary P Billman, Tayla M Olsen, Annette M Seilie, Ming Chang, Nahum Smith, Vorada Chuenchob, Sumana Chakravarty, B Kim Lee Sim, Stefan H I Kappe, Stephen L Hoffman, Robert A Seder
BACKGROUND: Plasmodium 18S rRNA is a biomarker used to monitor blood-stage infections in malaria clinical trials. Plasmodium sporozoites also express this biomarker, and there is conflicting evidence about how long sporozoite-derived 18S rRNA persists in peripheral blood. If present in blood for an extended timeframe, sporozoite-derived 18S rRNA could complicate use as a blood-stage biomarker. METHODS: Blood samples from Plasmodium yoelii infected mice were tested for Plasmodium 18S rRNA and their coding genes (rDNA) using sensitive quantitative reverse transcription PCR and quantitative PCR assays, respectively...
July 27, 2018: Malaria Journal
Soroush Tahmasebi, Arkady Khoutorsky, Michael B Mathews, Nahum Sonenberg
Advances in sequencing and high-throughput techniques have provided an unprecedented opportunity to interrogate human diseases on a genome-wide scale. The list of disease-causing mutations is expanding rapidly, and mutations affecting mRNA translation are no exception. Translation (protein synthesis) is one of the most complex processes in the cell. The orchestrated action of ribosomes, tRNAs and numerous translation factors decodes the information contained in mRNA into a polypeptide chain. The intricate nature of this process renders it susceptible to deregulation at multiple levels...
July 23, 2018: Nature Reviews. Molecular Cell Biology
Nahum Buzaglo, Mordechai Golomb, Haim Rosen, Ronen Beeri, Hagit Cohen-Ben Ami, Fattal Langane, Sandrine Pierre, David Lichtstein
Cardiac steroids (CSs), such as ouabain and digoxin, increase the force of contraction of heart muscle and are used for the treatment of congestive heart failure (CHF). However, their small therapeutic window limits their use. It is well established that Na+ , K+ -ATPase inhibition mediates CS-induced increase in heart contractility. Recently, the involvement of intracellular signal transduction was implicated in this effect. The aim of the present study was to test the hypothesis that combined treatment with ouabain and Akt inhibitor (MK-2206) augments ouabain-induced inotropy in mammalian models...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
Abbas Al-Kurd, Ronit Grinbaum, Tzlil Mordechay-Heyn, Salih Asli, Ala'a Abubeih, Ido Mizrahi, Haggi Mazeh, Nahum Beglaibter
BACKGROUND: Few previous studies have assessed the safety of bariatric surgery in septuagenarians. METHODS: A retrospective analysis of all patients 70 years or older who underwent laparoscopic sleeve gastrectomy at our institution between 2012 and 2017 was performed. This group was compared to a matched cohort of younger LSG patients (18-50 years) who were operated during the same time period. RESULTS: Thirty septuagenarian LSG patients were compared to 60 younger patients...
July 21, 2018: Obesity Surgery
E K Czyz, C A King, I Nahum-Shani
Despite its potential to yield information about the dynamic course of suicidal ideation/behavior in individuals' natural environment, Ecological Momentary Assessment (EMA) has been strikingly underutilized among suicidal teens. This study reports on feasibility and acceptability of ecological assessment of daily suicide risk-related outcomes ("daily diaries," a special case of EMA) among adolescent inpatients in the critical post-discharge period. Thirty-four adolescents (76% female; ages 13-17) responded to daily electronic surveys for four weeks after discharge...
September 2018: Psychiatry Research
Abbas Al-Kurd, Ronit Grinbaum, Ala'a Abubeih, Ariel Verbner, Amram Kupietzky, Ido Mizrahi, Haggi Mazeh, Nahum Beglaibter
INTRODUCTION: It is commonly stated in bariatric surgical forums that leaks following laparoscopic sleeve gastrectomy (LSG) are more difficult to manage than those following laparoscopic roux-en-Y gastric bypass (LRYGB). However, no previous study has provided a thorough comparison of leak management following these two operations. METHODS: Our database was retrospectively reviewed to identify patients with leak following LSG and LRYGB performed between January 2007 and December 2017...
July 19, 2018: Obesity Surgery
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