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Yoav Nahum, Irit Bahar, Massimo Busin
PURPOSE: To report the use of Descemet stripping automated endothelial keratoplasty (DSAEK) for treatment of sterile corneal perforations accompanying endothelial decompensation. METHODS: In this multicenter interventional case series, we reviewed the medical records of all tectonic DSAEK surgeries performed at Villa Serena-Villa Igea private Hospitals (Forlì, Italy) and Rabin Medical Center (Petach Tikva, Israel) between January 2014 and March 2016. RESULTS: Three patients with endothelial decompensation and sterile corneal perforation (n = 2) or impending corneal perforation (n = 1) underwent DSAEK between 2014 and 2015 at Villa Igea Hospital, Forlì, Italy, and Rabin Medical Center, Petach Tikva, Israel...
October 5, 2016: Cornea
Nahum Méndez-Sánchez
No abstract text is available yet for this article.
November 2016: Annals of Hepatology
Frank Lammert, Nahum Méndez-Sánchez
No abstract text is available yet for this article.
November 2016: Annals of Hepatology
Héctor Baptista-González, Victor M Noffal-Nuño, Nahum Méndez-Sánchez
:  Background and rationale for the study. The generation of people born before 1965 is a high-risk group for developing chronic hepatitis C virus (HCV) infection. AIM: To report the experience on single institution of HCV infection under birth-cohort or baby boomers effect. MATERIAL AND METHODS: We used a cross-sectional design of consecutive subjects older than 18 years referred for serological evaluation for anti-HCV and detection of HCV RNA...
November 2016: Annals of Hepatology
Nahum Méndez-Sánchez
No abstract text is available yet for this article.
November 2016: Annals of Hepatology
Anderson H Lima, Alberto M Dos Santos, Cláudio Nahum Alves, Jerônimo Lameira
UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is one of the key enzymes involved in peptidoglycan biosynthesis. The peptide HESFWYLPHQSY (called PEP 1354) is an inhibitor of MurA with an IC50 value of 200 μM. In this paper, we have used the FlexPepDock ab-initio protocol from the Rosetta program Homology Modeling and Molecular dynamics simulations to analyze, for the first time, the interaction of the PEP 1354 peptide with MurA enzyme from Pseudomonas aeruginosa (MurA-PA). Our modeling results suggest that the peptide binds to the same active site as the natural substrate UDP-N-acetylglucosamine (UNAG)...
October 13, 2016: Chemical Biology & Drug Design
Edlyn Wu, Ajay A Vashisht, Clément Chapat, Mathieu N Flamand, Emiliano Cohen, Mihail Sarov, Yuval Tabach, Nahum Sonenberg, James Wohlschlegel, Thomas F Duchaine
MicroRNAs (miRNAs) impinge on the translation and stability of their target mRNAs, and play key roles in development, homeostasis and disease. The gene regulation mechanisms they instigate are largely mediated through the CCR4-NOT deadenylase complex, but the molecular events that occur on target mRNAs are poorly resolved. We observed a broad convergence of interactions of germ granule and P body mRNP components on AIN-1/GW182 and NTL-1/CNOT1 in Caenorhabditis elegans embryos. We show that the miRISC progressively matures on the target mRNA from a scanning form into an effector mRNP particle by sequentially recruiting the CCR4-NOT complex, decapping and decay, or germ granule proteins...
October 3, 2016: Nucleic Acids Research
Arkady Khoutorsky, Robert E Sorge, Masha Prager-Khoutorsky, Sophie Anne Pawlowski, Geraldine Longo, Seyed Mehdi Jafarnejad, Soroush Tahmasebi, Loren J Martin, Mark H Pitcher, Christos G Gkogkas, Reza Sharif-Naeini, Alfredo Ribeiro-da-Silva, Charles W Bourque, Fernando Cervero, Jeffrey S Mogil, Nahum Sonenberg
A response to environmental stress is critical to alleviate cellular injury and maintain cellular homeostasis. Eukaryotic initiation factor 2 (eIF2) is a key integrator of cellular stress responses and an important regulator of mRNA translation. Diverse stress signals lead to the phosphorylation of the α subunit of eIF2 (Ser51), resulting in inhibition of global protein synthesis while promoting expression of proteins that mediate cell adaptation to stress. Here we report that eIF2α is instrumental in the control of noxious heat sensation...
October 3, 2016: Proceedings of the National Academy of Sciences of the United States of America
E Onjukka, J Uzan, C Baker, L Howard, A Nahum, I Syndikus
AIMS: For patients with high-risk, locally bulky prostate cancer, an intra-prostatic boost to tumour volumes (dose-painting) offers a risk-adapted dose escalation. We evaluated the feasibility of hypofractionated dose-painting radiotherapy and the associated toxicity. The possibility to streamline a radiobiologically optimised planning protocol was also investigated. MATERIALS AND METHODS: Twenty-eight patients were treated using a dose-painting approach; boost volumes were identified with functional magnetic resonance imaging scans...
September 29, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Inbal Nahum-Shani, Shawna N Smith, Bonnie J Spring, Linda M Collins, Katie Witkiewitz, Ambuj Tewari, Susan A Murphy
BACKGROUND: The just-in-time adaptive intervention (JITAI) is an intervention design aiming to provide the right type/amount of support, at the right time, by adapting to an individual's changing internal and contextual state. The availability of increasingly powerful mobile and sensing technologies underpins the use of JITAIs to support health behavior, as in such a setting an individual's state can change rapidly, unexpectedly, and in his/her natural environment. PURPOSE: Despite the increasing use and appeal of JITAIs, a major gap exists between the growing technological capabilities for delivering JITAIs and research on the development and evaluation of these interventions...
September 23, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Suyashree Bhonsle, Mohammad Bonakdar, Robert E Neal, Charles Aardema, John L Robertson, Jonathon Howarth, Helen Kavnoudias, Kenneth R Thomson, S Nahum Goldberg, Rafael V Davalos
PURPOSE: To develop and validate a perfused organ model for characterizing ablations for irreversible electroporation (IRE)-based therapies. MATERIALS AND METHODS: Eight excised porcine livers were mechanically perfused with a modified phosphate-buffered saline solution to maintain viability during IRE ablation. IRE pulses were delivered using 2 monopolar electrodes over a range of parameters, including voltage (1,875-3,000 V), pulse length (70-100 µsec), number of pulses (50-600), electrode exposure (1...
September 20, 2016: Journal of Vascular and Interventional Radiology: JVIR
Priya Handa, Akhila Vemulakonda, Kris V Kowdley, Misael Uribe, Nahum Méndez-Sánchez
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis (NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH...
August 21, 2016: World Journal of Gastroenterology: WJG
Marwan Moussa, S Nahum Goldberg, Gaurav Kumar, Tatyana Levchenko, Vladimir Torchilin, Muneeb Ahmed
PURPOSE: The aim of this study was to evaluate the effect of different radio-frequency ablation (RFA) thermal doses on coagulation and heat shock protein (HSP) response with and without adjuvant nanotherapies. MATERIALS AND METHODS: First, Fischer rats were assigned to nine different thermal doses of hepatic RFA (50-90 °C, 2-20 min, three per group) or no treatment (n = 3). Next, five of these RF thermal doses were combined with liposomal-doxorubicin (Lipo-Dox, 1 mg intravenously) in R3230 breast tumours, or no tumour treatment (five per group)...
December 2016: International Journal of Hyperthermia
Paloma Almeda-Valdes, Carlos A Aguilar-Salinas, Misael Uribe, Samuel Canizales-Quinteros, Nahum Méndez-Sánchez
BACKGROUND: The prevalence of obesity has increased worldwide in parallel with associated metabolic disturbances such as diabetes and non-alcoholic fatty liver disease. OBJECTIVE: The objective of this article is to underscore discrepancies in the standard anthropometric cut-off values and the presence of metabolic disturbances including diabetes and non-alcoholic fatty liver disease caused by biological and ethnic variations. MATERIALS AND METHODS: We performed a literature review regarding the diagnosis and prevalence of obesity, diabetes, metabolic syndrome and non-alcoholic fatty liver disease and about the different available indicators to define obesity...
September 7, 2016: European Journal of Clinical Investigation
Nahum Elhai, Sara Carmel, Norm O'Rourke, Yaacov G Bachner
INTRODUCTION: The SHALOM questionnaire is based on a multidimensional perception of spirituality. This study examines the psychometric properties and factorial structure of the Hebrew version of Fisher's SHALOM questionnaire. METHODS: The study included 341 participants. Tools included the SHALOM questionnaire and measures for evaluation of well-being. The factorial structure of the SHALOM was evaluated using exploratory factor analysis (EFA). Concurrent validity was also tested...
September 5, 2016: Aging & Mental Health
Kun Yan, Wei Yang, Min-Hua Chen, Zhong-Yi Zhang, Jung-Chieh Lee, Hai-Xing Liao, Wei Wu, S Nahum Goldberg
PURPOSE: To determine the efficacy and safety of percutaneous hepatic wedge ablation in treating hepatic malignancies of the inferior margin. MATERIALS AND METHODS: 77 patients with hepatic malignancies at the inferior margin underwent percutaneous radiofrequency ablation (RFA). 32 patients underwent hepatic wedge ablation and 45 patients underwent conventional tumor ablation. Comparative analysis of the two groups was performed including gender, age, tumor size, number of ablation cycles, ablation duration, and injected hydrodissection volume...
September 2, 2016: International Journal of Hyperthermia
Giovanni Borasi, Alan Nahum
PURPOSE: In recent years, the reaction-diffusion (Fisher-Kolmogorov) equation has received much attention from the oncology research community due to its ability to describe the infiltrating nature of glioblastoma multiforme and its extraordinary resistance to any type of therapy. However, in a number of previous papers in the literature on applications of this equation, the term (R) expressing the 'External Radiotherapy effect' was incorrectly derived. In this note we derive an analytical expression for this term in the correct form to be included in the reaction-diffusion equation...
September 2016: Physica Medica: PM
Adi Tsalach, Eliahu Ratner, Stas Lokshin, Zmira Silman, Ilan Breskin, Nahum Budin, Moshe Kamar
Cerebral autoregulation is a mechanism which maintains constant cerebral blood flow (CBF) despite changes in mean arterial pressure (MAP). Assessing whether this mechanism is intact or impaired and determining its boundaries is important in many clinical settings, where primary or secondary injuries to the brain may occur. Herein we describe the development of a new ultrasound tagged near infra red light monitor which tracks CBF trends, in parallel, it continuously measures blood pressure and correlates them to produce a real time autoregulation index...
2016: PloS One
Yoshinori Tsukumo, Nahum Sonenberg, Tommy Alain
No abstract text is available yet for this article.
August 26, 2016: Cell Cycle
Josep M Alegret, Neus Martinez-Micaelo, Andre La Gerche, Luis Franco-Bonafonte, Francisco Rubio-Pérez, Nahum Calvo, Manuel Montero
OBJECTIVE: In patients with aortic regurgitation (AR), the effect of static exercise (SE) on global ventricular function and AR severity has not been previously studied. METHODS: Resting and SE cardiovascular magnetic resonance (CMR) were prospectively performed in 23 asymptomatic patients with AR. RESULTS: During SE, we observed a decrease in regurgitant volume in both end-diastolic (EDV) and end-systolic (ESV) volume in both ventricles, as well as a slight decrease in LV ejection fraction (EF)...
August 23, 2016: European Radiology
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