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Nocturnal polyuria

Ana L Lopes Mendes, Veerle Decalf, Marie A Denys, Andrea Tubaro, Karel Everaert
BACKGROUND: Bladder dysfunctions often express the presence of lower urinary tract symptoms (LUTS) and are common in older people. Aim of this study is to analyse the Micturition, Incontinence and Residual in older people, evaluating the role of Nocturnal Polyuria. METHODS: 86 patients with at least 65 years old and invalidating LUTS were hospitalized for 24 hours. The Maximum Bladder Capacity, mean Micturition Volume, Post Voiding Residual and Incontinence Volume were recorded and analysed day-time and night-time...
October 5, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Amit Batla, Natalie Tayim, Mahreen Pakzad, Jalesh N Panicker
Urogenital dysfunction is commonly reported in Parkinson's disease (PD), and history taking and a bladder diary form the cornerstone of evaluation. The assessment of lower urinary tract (LUT) symptoms include urinalysis, ultrasonography, and urodynamic studies and help to evaluate concomitant urological pathologies such as benign prostate enlargement. Antimuscarinic medications are the first line treatment for overactive bladder (OAB) symptoms and solifenacin has been specifically studied in PD. Antimuscarininc drugs may exacerbate PD-related constipation and xerostomia, and caution is advised when using these medications in individuals where cognitive impairment is suspected...
October 2016: Current Treatment Options in Neurology
Shachi Tyagi, Subashan Perera, Becky D Clarkson, Stasa D Tadic, Neil M Resnick
PURPOSE: Nocturia is common and bothersome in older adults especially those who are also incontinent. Since nocturnal polyuria (NP) is a major contributor, we examined factors associated with NP in this population to identify those possibly amenable to intervention. METHOD: We analyzed baseline data from two previously-completed studies of urge urinary incontinence (UUI). The studies involved 284 women (mean 72.9 ±7.9 years) who also completed 3-day voiding diaries...
September 24, 2016: Journal of Urology
Masaki Yamamoto, Takahiro Shimizu, Shogo Shimizu, Youichirou Higashi, Kumiko Nakamura, Mikiya Fujieda, Motoaki Saito
Naftopidil, an α1-adrenoceptor antagonist, has been shown to inhibit nocturnal polyuria in patients with lower urinary tract symptom. However, it remains unclear how naftopidil decreases nocturnal urine production. Here, we investigated the effects of naftopidil on arginine-vasopressin (AVP) plasma level and urine production and osmolality in rats centrally administered with noradrenaline (NA). NA (3 or 30 μg/kg) was administered into the left ventricle (i.c.v.) of male Wistar rats 3 h after naftopidil pretreatment (10 or 30 mg/kg, i...
September 2016: Journal of Pharmacological Sciences
Joon Chul Kim, Kang Jun Cho, Jeong Gu Lee, Ju Tae Seo, Duk Yoon Kim, Seung-June Oh, Kyu-Sung Lee, Myung-Soo Choo, Jeong Zoo Lee
PURPOSE: We investigated the efficacy and safety of desmopressin add-on therapy in men with persistent nocturia on alpha-blocker for lower urinary tract symptoms (LUTS) with placebo-controlled study. MATERIALS AND METHODS: The study included men aged 40-65 years with LUTS and persistent nocturia despite alpha-blocker for at least 8 weeks. The patients were randomized to once-daily placebo or desmopressin 0.2 mg for 8 weeks. The primary end point was to assess changes in the mean number of nocturia episodes from the baseline to the final assessment...
September 10, 2016: Journal of Urology
Ádám Miklós Fehér, Zoltán Bajory
Nocturia is a significantly underestimated disorder, resulting in general worsening of patients' quality of life, while morbidity and mortality are increasing. Several urologic and other pathologic causes can be described in the background including relatively severe conditions. Therefore, accurate evaluation and adequate treatment is recommended. In this review the authors summarize the international literature regarding nocturia. PubMed and ScienceDirect databases were accurately reviewed for the relevant information...
September 2016: Orvosi Hetilap
Osamu Yokoyama, Osamu Nishizawa, Yukio Homma, Masayuki Takeda, Momokazu Gotoh, Hidehiro Kakizaki, Hironobu Akino, Koichi Hayashi, Koji Yonemoto
PURPOSE: The objective of this multicenter, cross-sectional study was to investigate the relationship of nocturnal polyuria in patients with common lifestyle-related diseases and overactive bladder (OAB), with special attention to hypertension. MATERIALS AND METHODS: After baseline assessment, patients recorded their 24-hour urinary frequency/volume, blood pressure, and heart rate for 3 days, and were stratified into 4 groups based on mean blood pressure (no hypertension, controllable, untreated, and uncontrolled hypertension)...
August 23, 2016: Journal of Urology
M A Denys, A Viaene, A S Goessaert, F Vanhaverbeke, P Hoebeke, A Raes, K Everaert
PURPOSE: To evaluate nocturnal urine production and circadian rhythms of renal functions (glomerular filtration, water and solute diuresis) in adults with a spinal cord injury compared to controls. MATERIALS AND METHODS: This prospective observational study was conducted in Ghent University Hospital, Belgium. Participants were asked to perform a 24h urine collection and a blood sample was taken to calculate diuresis rate and renal clearance of creatinine, free water, solutes, sodium and urea...
August 6, 2016: Journal of Urology
Rajiv Sinha, Sumantra Raut
Nocturnal enuresis often causes considerable distress or functional impairment to patient and their parents necessitating a multidisciplinary approach from paediatrician, paediatric nephrologist, urologists and psychiatrist. Mechanisms of monosymptomatic nocturnal enuresis are mainly nocturnal polyuria, bladder overactivity and failure to awaken from sleep in response to bladder sensations. Goal oriented and etiology wise treatment includes simple behavioral intervention, conditioning alarm regimen and pharmacotherapy with desmopressin, imipramine and anticholinergic drugs...
July 6, 2016: World Journal of Nephrology
Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Satoru Kira, Tatsuya Miyamoto, Hiroshi Nakagomi, Norifumi Sawada, Yuri Hirayama, Keisuke Shibata, Eiji Shigetomi, Yoichi Shinozaki, Mitsuharu Yoshiyama, Karl-Erik Andersson, Atsuhito Nakao, Masayuki Takeda, Schuichi Koizumi
AIMS: The pathophysiologies of nocturia (NOC) and nocturnal polyuria (NP) are multifactorial and their etiologies remain unclear in a large number of patients. Clock genes exist in most cells and organs, and the products of Clock regulate circadian rhythms as representative clock genes. Clock genes regulate lower urinary tract function, and a newly suggested concept is that abnormalities in clock genes cause lower urinary tract symptoms. In the present study, we investigated the voiding behavior of Clock mutant (Clock(Δ19/Δ19) ) mice in order to determine the effects of clock genes on NOC/NP...
June 27, 2016: Neurourology and Urodynamics
Keisuke Kiba, Akihide Hirayama, Motokiyo Yoshikawa, Yutaka Yamamoto, Kazumasa Torimoto, Kiyohide Fujimoto, Hirotsugu Uemura
A total of 29 men 60 years and older (mean age 74 years) who complained at least once about nocturnal voiding and were diagnosed with nocturnal polyuria in the frequency volume chart (FVC) were enrolled in this study. Body water was measured by bioelectric impedance analysis just after lying down at 4 pm and after raising legs 30 minutes later. Nocturnal urine production was measured by FVC, and urine production per unit of time at first nocturnal voiding (urine volume at first nocturnal voiding/hours of undisturbed sleep (HUS) : UFN/HUS), urine production per unit of time during sleep (total nocturnal urine volume/hours of sleep : TNV/HS), etc was evaluated...
May 2016: Hinyokika Kiyo. Acta Urologica Japonica
Alan J Wein
No abstract text is available yet for this article.
April 2016: Journal of Urology
M A Denys, E Bruneel, S Van Laecke, J P Nørgaard, K Everaert
OBJECTIVES: Describe current shortcomings in clinical research on the treatment of nocturia in adults, and suggest new directions for future studies in this field. METHODS: A literature search was conducted using the keywords 'nocturia,' 'nocturnal polyuria,' 'sleep,' and 'hypertension.' RESULTS: Nocturia, or waking up at night to void, is a highly prevalent and bothersome lower urinary tract symptom (LUTS) affecting up to 40% of adults. Since the majority of patients are diagnosed with nocturnal polyuria (NP) as one of the underlying causes, it is not surprising that the effect of treatments for overactive bladder (OAB) and bladder outlet obstruction (BOO) are disappointing with regard to nocturia...
May 10, 2016: Acta Clinica Belgica
L Dossche, J Vande Walle, C Van Herzeele
UNLABELLED: Nocturnal polyuria in monosymptomatic nocturnal enuresis (MNE) has so far mainly been attributed to a disturbed circadian rhythm of renal water handling. Low vasopressin levels overnight correlate with absent maximal concentrating activity, resulting in an increased nocturnal diuresis with low urinary osmolality. Therefore, treatment with desmopressin is a rational choice. Unfortunately, 20 to 60 % of children with monosymptomatic enuresis are desmopressin-resistant. There is increasing evidence that other disturbed circadian rhythms might play a role in nocturnal polyuria...
June 2016: European Journal of Pediatrics
Aya Niimi, Motofumi Suzuki, Yasuhiro Yamaguchi, Masaki Ishii, Tetsuya Fujimura, Tohru Nakagawa, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Masahiro Akishita, Yukio Homma
PURPOSE: We investigated the relationships among nocturnal polyuria, sleep apnea and body fluid volume to elucidate the pathophysiology of nocturia in sleep apnea syndrome. MATERIALS AND METHODS: We enrolled 104 consecutive patients who underwent polysomnography for suspected sleep apnea syndrome. Self-assessed symptom questionnaires were administered to evaluate sleep disorder and lower urinary tract symptoms, including nocturia. Voiding frequency and voided volume were recorded using a 24-hour frequency-volume chart...
October 2016: Journal of Urology
Konstantinos Kamperis, Charlotte Van Herzeele, Soren Rittig, Johan Vande Walle
Most patients with monosymptomatic nocturnal enuresis can be effectively treated with an enuresis alarm or antidiuretic therapy (desmopressin), depending on the pathophysiology of the condition in the individual patient. Desmopressin is first-line therapy for enuresis caused by nocturnal polyuria, an excessive urine output during the night. However, in a recent study, around one-third of patients thought to be resistant to desmopressin were subsequently treated effectively with desmopressin monotherapy in a specialist centre...
April 12, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Charlotte Van Herzeele, Karlien Dhondt, Sanne P Roels, Ann Raes, Piet Hoebeke, Luitzen-Albert Groen, Johan Vande Walle
BACKGROUND: There is a high comorbidity between nocturnal enuresis, sleep disorders and psychological problems. The aim of this study was to investigate whether a decrease in nocturnal diuresis volume not only improves enuresis but also ameliorates disrupted sleep and (neuro)psychological dysfunction, the major comorbidities of this disorder. METHODS: In this open-label, prospective phase IV study, 30 children with monosymptomatic nocturnal enuresis (MNE) underwent standardized video-polysomnographic testing and multi-informant (neuro)psychological testing at baseline and 6 months after the start of desmopressin treatment in the University Hospital Ghent, Belgium...
September 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Wendy F Bower, D Michael Whishaw, Fary Khan
AIMS: Nocturia is a common symptom of many conditions and is encountered in patients presenting to services across different medical specialities and health disciplines. The causal pathway of nocturia is multi-factorial and differs between patients. There is currently no symptom-specific clinical algorithm for all-cause diagnosis of nocturia. The aim of this study was to investigate the interrelationships between causes of nocturia in order to inform the development of a comprehensive multidisciplinary assessment metric...
April 6, 2016: Neurourology and Urodynamics
S-L Chen, Y-H Huang, T-W Hung, Y-C Ou
OBJECTIVES: To evaluate the safety and efficacy of low-dose desmopressin in elderly men with and without nocturnal polyuria (NP) in real-life practice. METHODS: Patients with lower urinary tract symptoms (LUTS)/ benign prostate hyperplasia (BPH) who were≧ 65 years old with refractory nocturia were enrolled in this study. We retrospectively analysed elderly men treated with adding desmopressin to current medications for nocturia according to category of the baseline nocturnal urine volume...
May 2016: International Journal of Clinical Practice
Byung Hoon Kim, Ki Ho Kim, Young Hwii Ko, Phil Hyun Song, Tae-Hwan Kim, Bum Soo Kim
BACKGROUND: We evaluated ultrasonography variables associated with the improvement of nocturia after administration of alpha adrenoceptor antagonist (alpha blocker) monotherapy. METHODS: From February to October 2014, 679 men with lower urinary tract symptoms (LUTS) underwent ultrasonography including prostate volume, transitional zone volume, prostatic urethral length, the ratio between prostatic urethral length and prostate volume (RPUL), intravesical prostatic protrusion (IPP), and prostatic urethral angle (PUA)...
March 2016: Prostate International
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