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https://www.readbyqxmd.com/read/28932951/structure-elucidation-and-in-silico-docking-studies-of-a-novel-furopyrimidine-antibiotics-synthesized-by-endolithic-bacterium-actinomadura-sp-al2
#1
Kaushik Bhattacharjee, Shakti Kumar, Narasinga Rao Palepu, Pradeep Kumar Patra, Kollipara Mohan Rao, Santa Ram Joshi
On screening of endolithic actinobacteria from a granite rock sample of Meghalaya for antibacterial compound, a novel antibacterial compound CCp1 was isolated from the fermentation broth of Actinomadura sp. AL2. On purification of the compound based on chromatographic techniques followed by characterization with FT-IR, UV-visible, (1)H NMR, (13)C NMR and mass spectrometry, the molecular formula of the compound was generated as C20H17N3O2, a furopyrimidine derivative. In vitro antibacterial activity of the compound was evaluated against both Gram positive and negative bacteria by agar well diffusion assay...
September 20, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28929959/-in-vitro-effect-of-vancomycin-and-daptomycin-on-biofilm-formation-of-coagulase-negative-staphylococci-strains
#2
Duygu Nilüfer Öcal, İştar Dolapçı, Zeynep Gençtürk, Alper Tekeli
Coagulase-negative staphylococci (CNS) are one of the primer agents of blood stream infections (BSI) and catheter-related bloodstream infections (CR-BSI) which are associated mostly with the usage of central venous catheters and, important causes of morbidity and mortality despite the usage of antibacterial and supportive treatment. It is important to determine the properties of these causative microorganisms in order to make appropriate treatment of such infections. The aims of our study were to evaluate the biofilm formation of coagulase negative staphylococci (CNS) which were causative agents of bloodstream (BSI) and catheter related bloodstream infections (CR-BSI), to determine the minimum inhibitory concentration (MIC) of planktonic forms and minimal biofilm eradication concentration (MBEC) of sessile forms for vancomycin and daptomycin and to evaluate the efficacy of these antibiotics in infections with biofilm-forming isolates in vitro...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929050/synergistic-effect-of-carum-copticum-and-mentha-piperita-essential-oils-with-ciprofloxacin-vancomycin-and-gentamicin-on-gram-negative-and-gram-positive-bacteria
#3
Gholam-Reza Talei, Mohsen Mohammadi, Mahmoud Bahmani, Mahmoud Rafieian Kopaei
BACKGROUND: Infectious diseases have always been an important health issue in human communities. In the recent years, much research has been conducted on antimicrobial effects of nature-based compounds because of increased prevalence of antibiotic resistance. The present study was conducted to investigate synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram-negative and Gram-positive bacteria. MATERIALS AND METHODS: In this experimental study, the synergistic effects of C...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28927452/vancomycin-heteroresistance-in-coagulase-negative-staphylococcus-blood-stream-infections-from-patients-of-intensive-care-units-in-mansoura-university-hospitals-egypt
#4
Ghada El-Saeed Mashaly, Rasha Hassan El-Mahdy
BACKGROUND: Vancomycin heteroresistance in coagulase negative Staphylococci (CoNS) is a recent health concern especially in serious infections like bloodstream infections as it may lead to failure of therapy. Little information is available about the prevalence vancomycin heteroresistance in CoNS causing bloodstream infections in intensive care units (ICUs) patients of Mansoura University Hospitals (MUHs). METHODS: This prospective study enrolled 743 blood samples collected from ICUs patients presented with clinical manifestations of bloodstream infections over the period extending from January 2014 to March 2016...
September 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28926883/-etiological-analysis-and-in-vitro-drug-sensitivity-of-bacterial-keratitis-in-northern-china-in-the-period-of-2006-2015
#5
Y Zhang, Z Q Wang, X G Sun
Objective: To analyze the etiology and drug sensitivity of bacterial keratitis and their changes, and to provide evidence for treatment and drug selection of bacterial keratitis. Methods: Retrospective case series study. From January 2006 to December 2015, corneal specimens suspected of bacterial infection were collected and cultured in Beijing Tongren Eye Center. General information of patients, etiological results and drug sensitivity test results were summarized and analyzed. The Chi-square test and Spearman correlation analysis were performed using SPSS 20...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28925304/antibacterial-antioxidant-and-cytotoxic-activities-of-triterpenes-and-flavonoids-from-the-aerial-parts-of-salvia-barrelieri-etl
#6
Meryem Lehbili, Abdulmagid Alabdul Magid, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Amin Abedini, Hamid Morjani, Sophie C Gangloff, Zahia Kabouche
From the aerial parts of Salvia barrelieri Etl. (Lamiaceae), 12 compounds including a new triterpene, 3β-acetoxy-olean-18-ene-2α-ol, were isolated. Their structures were established by the combination analyses of spectroscopy including 1D-, 2D-NMR and HRESIMS and in comparison with the reported data in the literature. The antibacterial activity of these compounds was evaluated by bioautography on Staphylococcus aureus followed by the determination of MIC values by serial dilution technique against five bacteria...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28922631/surface-modification-of-platelet-concentrate-bags-to-reduce-biofilm-formation-and-transfusion-sepsis
#7
Joels S T Wilson-Nieuwenhuis, Nina Dempsey-Hibbert, Christopher M Liauw, Kathryn A Whitehead
Bacterial contamination of blood products poses a major risk in transfusion medicine, including transfusions involving platelet products. Although testing systems are in place for routine screening of platelet units, the formation of bacterial biofilms in such units may decrease the likelihood that bacteria will be detected. This work determined the surface properties of p-PVC platelet concentrate bags and investigated how these characteristics influenced biofilm formation. Serratia marcescens and Staphylococcus epidermidis, two species commonly implicated in platelet contamination, were used to study biofilm growth...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28922060/risk-factors-for-nasal-colonization-by-methicillin-resistant-staphylococci-in-healthy-humans-in-professional-daily-contact-with-companion-animals-in-portugal
#8
Ana Catarina Rodrigues, Adriana Belas, Cátia Marques, Luís Cruz, Luís T Gama, Constança Pomba
Methicillin-resistant staphylococci (MRS), namely Staphylococcus aureus (MRSA) and Staphylococcus pseudintermedius (MRSP), are opportunistic agents of great importance in human and veterinary medicine. The aims of this study were to investigate the frequency, persistence, and risk factors associated with nasal colonization by MRS in people in daily contact with animals in Portugal. Seventy-nine out of 129 (61.2%) participants were found to be colonized by, at least, one methicillin-resistant (MR) staphylococci species (MR Staphylococcus epidermidis [n = 68], MRSA [n = 19], MR Staphylococcus haemolyticus [n = 7], MRSP [n = 2], and other coagulase-negative staphylococci [n = 4])...
September 18, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28919860/a-multidirectional-perspective-for-novel-functional-products-in-vitro-pharmacological-activities-and-in-silico-studies-on-ononis-natrix-subsp-hispanica
#9
Serife Yerlikaya, Gokhan Zengin, Adriano Mollica, Mehmet C Baloglu, Yasemin Celik Altunoglu, Abdurrahman Aktumsek
The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28919748/antibacterial-properties-of-pekk-for-orthopedic-applications
#10
Mian Wang, Garima Bhardwaj, Thomas J Webster
Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919615/microbiology-of-chronic-suppurative-otitis-media-in-a-tertiary-care-hospital-in-bangladesh
#11
N Akhtar, P G Datta, M Yasmin, A Naha, A M Jewel, F Hossen, S Ahmed, U K Datta
This cross sectional prospective study was carried out in the Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Department of Microbiology, University of Dhaka from July 2012 to June 2013. The objectives of this study were to identify the common microorganisms involved and the antibiograms of chronic suppurative otitis media (CSOM) patients in this tertiary care hospital in Bangladesh. A total of 117 patients clinically diagnosed of CSOM were enrolled in the study...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28916044/antibiotic-affinity-strategy-for-bioluminescent-detection-of-viable-gram-positive-bacteria-using-daptomycin-as-recognition-agent
#12
Mengyao Wang, Yue Wu, Yong He, Xiaoxiao Su, Hui Ouyang, Zhifeng Fu
A bioluminescent method was proposed for rapid detection of viable Gram-positive bacteria based on a novel antibiotic-affinity strategy on a magnetic beads (MBs) platform. Daptomycin, a highly efficient lipopeptide antibiotic for Gram-positive bacteria, was used as a recognition agent to functionalize MBs. The daptomycin-functionalized MBs showed high capture and concentration efficiency for Gram-positive bacteria due to the strong binding between daptomycin and bacterial cell membrane in the presence of Ca(2+) ion...
September 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28911620/composition-of-asarum-heterotropoides-var-mandshuricum-radix-oil-from-different-extraction-methods-and-activities-against-human-body-odor-producing-bacteria
#13
A S M Tanbirul Haque, Jin Nam Moon, P S Saravana, Adane Tilahun, Byung-Soo Chun
In this study, oils from Asarum heterotropoides were extracted by traditional solvent extraction and supercritical CO2 (SC-CO2) extraction methods and their antioxidant activities along with antimicrobial and inhibitory activities against five human body odor-producing bacteria (Staphylococcus epidermidis, Propionibacterium freudenreichii, Micrococcus luteus, Corynebacterium jeikeium, and Corynebacterium xerosis) were evaluated. The oil was found to contain 15 components, among which the most abundant component was methyl eugenol (37...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911609/antibacterial-and-laxative-activities-of-strictinin-isolated-from-pu-er-tea-camellia-sinensis
#14
Sheng-Kuo Hsieh, Jun-Rui Xu, Nan-Hei Lin, Yue-Chiun Li, Guan-Heng Chen, Ping-Chung Kuo, Wen-Ying Chen, Jason T C Tzen
Strictinin, the major phenolic compound in Pu'er teas produced from young leaves and buds of wild trees, was isolated to evaluate its antibacterial and laxative activities. The minimum inhibitory concentrations of strictinin against Propionibacterium acnes and Staphylococcus epidermidis were determined as 250 μM and 2000 μM, respectively, apparently higher than those of several antibiotics commonly used for bacterial infections. The additive and synergistic effects on the inhibitory activities of strictinin combined with other commercial antibiotics were observed in two bacteria tested in this study via the analysis of fractional inhibitory concentrations...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906479/characterization-of-vb_saum-frusau02-a-twort-like-bacteriophage-isolated-from-a-therapeutic-phage-cocktail
#15
Katarzyna Leskinen, Henni Tuomala, Anu Wicklund, Jenni Horsma-Heikkinen, Pentti Kuusela, Mikael Skurnik, Saija Kiljunen
Staphylococcus aureus is a commensal and pathogenic bacterium that causes infections in humans and animals. It is a major cause of nosocomial infections worldwide. Due to increasing prevalence of multidrug resistance, alternative methods to eradicate the pathogen are necessary. In this respect, polyvalent staphylococcal myoviruses have been demonstrated to be excellent candidates for phage therapy. Here we present the characterization of the bacteriophage vB_SauM-fRuSau02 (fRuSau02) that was isolated from a commercial Staphylococcus bacteriophage cocktail produced by Microgen (Moscow, Russia)...
September 14, 2017: Viruses
https://www.readbyqxmd.com/read/28905380/enhancing-blood-donor-skin-disinfection-using-natural-oils
#16
Meshari Alabdullatif, Imen Boujezza, Mohamed Mekni, Mariam Taha, Dilini Kumaran, Qi-Long Yi, Ahmed Landoulsi, Sandra Ramirez-Arcos
BACKGROUND: Effective donor skin disinfection is essential in preventing bacterial contamination of blood components with skin flora bacteria like Staphylococcus epidermidis. Cell aggregates of S. epidermidis (biofilms) are found on the skin and are resistant to the commonly used donor skin disinfectants chlorhexidine-gluconate and isopropyl alcohol. It has been demonstrated that essential oils synergistically enhance the antibacterial activity of chlorhexidine-gluconate. The objective of this study was to test plant-extracted essential oils in combination with chlorhexidine-gluconate or chlorhexidine-gluconate plus isopropyl alcohol for their ability to eliminate S...
September 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28893370/inhibitory-efficacy-of-geraniol-on-biofilm-formation-and-development-of-adaptive-resistance-in-staphylococcus-epidermidis-rp62a
#17
Arunachalam Kannappan, Murugesan Sivaranjani, Ramanathan Srinivasan, Janarthanam Rathna, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
PURPOSE: The current study has been designed to delineate the efficacy of geraniol (GE) on biofilm formation in Staphylococcus epidermidis as well as the effect of subinhibitory concentrations of GE on the development of adaptive resistance. METHODOLOGY: Biofilm biomass quantification assay was performed to evaluate the antibiofilm activity of GE against S. epidermidis. Microscopic observation of biofilms and extracellular polymeric substance (EPS), slime and cell surface hydrophobicity (CSH) production were also studied to support the antibiofilm potential of GE...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28892893/distribution-of-sccmec-elements-and-presence-of-panton-valentine-leukocidin-in-methicillin-resistant-staphylococcusepidermidis-isolated-from-clinical-samples-in-a-university-hospital-of-isfahan-city-iran
#18
Mehrdad Halaji, Ashkan Karimi, Parisa Shoaei, Mohammadreza Nahaei, Farzin Khorvash, Behrooz Ataei, Majid Yaran, Seyed Asghar Havaei
INTRODUCTION: Coagulase Negative Staphylococcus (CoNS) is considered as a major pathogen of nosocomial infections among immunosuppressed patients. AIM: The aim of this study was to identify the types of Staphylococcal Cassette Chromosome mec (SCCmec) and Panton-Valentine Leukocidin (PVL) gene among clinical Methicillin-Resistant S. epidermidis (MRSE) isolates collected from Isfahan. MATERIALS AND METHODS: This cross-sectional study was performed from March 2014 to January 2015 at a tertiary care hospital of Isfahan, Iran...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890180/effectiveness-of-meibomian-gland-massage-combined-with-topical-levofloxacin-against-ocular-surface-flora-in-patients-before-penetrating-ocular-surgery
#19
Shao Dan Zhang, Jing Na He, Tong Tong Niu, Shan Shan Liu, Chiu Yeung Chan, Chun Yang Ren, Chi Liu, Chi Pui Pang, Yang Qu, Ruo Xi Li, Hai Lin Wang
OBJECTIVE: To investigate the bacterial profile in the conjunctiva and meibomian glands in patients before penetrating ocular surgeries, and to compare the anti-bacterial efficacy of 0.5% levofloxacin and its combination with meibomian gland massage. DESIGN: Hospital-based, case-control study. PARTICIPANTS: Two hundred and twenty-six eyes from 226 patients with non-infective ocular diseases and scheduled for penetrating ocular surgeries. METHODS: Tested eyes were administered with topical 0...
September 7, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28887459/the-unexpected-role-of-bioaerosols-in-the-oxidative-potential-of-pm
#20
A Samake, G Uzu, J M F Martins, A Calas, E Vince, S Parat, J L Jaffrezo
Bioaerosols represent up to 15-25% of PM by mass, but there is currently no assessment of their impact on Oxidative Potential (OP), or capacity of particulate matter (PM) to produce damaging oxidative reactions in the human lungs. Here, the OP of selected bioaerosols (bacteria cells vs fungal spores) was assessed through the cell-free DTT assay. Results show that bioaerosols induce Reactive Oxygen Species (ROS) production, varying along the microorganism type, species, and concentration. Fungal spores show up to 10 times more ROS generation than bacterial cells...
September 8, 2017: Scientific Reports
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