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https://www.readbyqxmd.com/read/27930849/searching-for-a-potential-antibacterial-lead-structure-against-bacterial-biofilms-among-new-naphthoquinone-compounds
#1
Caroline S Moreira, Ana Carolina J A Silva, Juliana S Novais, Agnes Marie Sá Figueiredo, Vítor F Ferreira, David R da Rocha, Helena C Castro
AIMS: The aims of this study were design, synthesis and the evaluation of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against gram-negative and Gram-positive strains, including MRSA and its biofilm, to probe for potential lead structures METHODS AND RESULTS: Thus, 36 new analogs were prepared with good yields using a simple, fast, operational three-procedure reaction and a thiol addition to an ο-quinone methide using microwave irradiation. All compounds were tested against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis ATCC 15290, Serratia marcescens ATCC 14756, Klebsiella pneumoniae ATCC 4352, Enterobacter cloacae ATCC 23355, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, S...
December 8, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27930835/effect-of-antibiotics-on-biofilm-inhibition-and-induction-measured-by-real-time-cell-analysis
#2
Maria D Ferrer, Juan C Rodriguez, Ledicia Álvarez, Alejandro Artacho, Gloria Royo, Alex Mira
AIMS: The purpose of the current work was to study the pattern and dynamics of biofilm formation in clinical isolates of Staphylococcus aureus and S. epidermidis in the presence of 10 antibiotics with different action mechanisms. METHODS AND RESULTS: By using impedance measurements in microtiter plates with gold electrodes we have assessed the antibiotic effect on bacterial biofilm growth in real time. The impedance measurements appear to combine both cellular growth and matrix production, representing a measurement of total biofilm mass...
December 8, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27930711/licheniocin-50-2-and-bacteriocins-from-lactococcus-lactis-subsp-lactis-biovar-diacetylactis-bgbu1-4-inhibit-biofilms-of-coagulase-negative-staphylococci-and-listeria-monocytogenes-clinical-isolates
#3
Ivana Cirkovic, Dragana D Bozic, Veselin Draganic, Jelena Lozo, Tanja Beric, Milan Kojic, Biljana Arsic, Eliana Garalejic, Slobodanka Djukic, Slavisa Stankovic
BACKGROUND: Coagulase negative staphylococci (CoNS) and Listeria monocytogenes have important roles in pathogenesis of various genital tract infections and fatal foetomaternal infections, respectively. The aim of our study was to investigate the inhibitory effects of two novel bacteriocins on biofilms of CoNS and L. monocytogenes genital isolates. METHODS: The effects of licheniocin 50.2 from Bacillus licheniformis VPS50.2 and crude extract of bacteriocins produced by Lactococcus lactis subsp...
2016: PloS One
https://www.readbyqxmd.com/read/27925693/identification-of-n-arylated-nh125-analogues-as-rapid-eradicating-agents-against-mrsa-persister-cells-and-potent-biofilm-killers-of-gram-positive-pathogens
#4
Yasmeen Abouelhassan, Akash Basak, Hussain Yousaf, Robert William Huigens Iii
Bacterial biofilms housing dormant persister cells are innately tolerant to antibiotics and disinfectants, yet several membrane-active agents are known to eradicate tolerant bacterial cells. NH125, a membrane-active persister-killer and starting point for development, led to the identification of N-arylated analogues 1 and 2 and displayed improved biofilm-killing potencies and rapid persister-killing activities in stationary cultures of methicillin-resistant Staphylococcus aureus (MRSA). We found 1 and 2 to be superior to other membrane-active agents in biofilm eradication assays with 1 demonstrating minimum biofilm eradication concentrations (MBEC) of 23...
December 7, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27924594/adhesion-of-yeast-and-bacteria-to-oral-surfaces
#5
Richard D Cannon, Karl M Lyons, Kenneth Chong, Kathryn Newsham-West, Kyoko Niimi, Ann R Holmes
Colonization of surfaces in the human body by microorganisms is an early, essential, step in the initiation of infectious disease. We have developed in vitro assays to investigate interactions between yeast or bacterial cells and human tissues, fluids, or prostheses. Such assays can be used to identify the adhesins, ligands, and receptors involved in these interactions, for example, by determining which components of the microbe or human tissue/fluid interfere with adherence in the assay. The assays can also be applied to finding ways of preventing adhesion, and subsequent disease, by investigating the effects of different conditions and added compounds on adherence in the in vitro assays...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27919672/a-study-of-pre-operative-presence-of-micro-organisms-in-affected-knee-joints-of-rheumatoid-arthritis-patients-who-need-total-knee-arthroplasty
#6
Jiang-Ming Luo, Lin Guo, Hao Chen, Peng-Fei Yang, Ran Xiong, Yang Peng, Liu Yang
BACKGROUND: To evaluate, by way of intraoperative tissue culture and pathological study, the pre-operative presence of micro-organisms in knee joints of patients with rheumatoid arthritis (RA) who need total knee arthroplasty (TKA). METHODS: From November 2012 to January 2014, 47 patients with RA (53 knees) who needed TKA were included in this study. Patients received routine pre-operative examination and joint fluid routine and culture. Each RA patient was match-paired with one osteoarthritis (OA) patient...
December 2, 2016: Knee
https://www.readbyqxmd.com/read/27912796/staphylococcal-species-heterogeneity-in-the-nasal-microbiome-following-antibiotic-prophylaxis-revealed-by-tuf-gene-deep-sequencing
#7
Claire L McMurray, Katherine J Hardy, Szymon T Calus, Nicholas J Loman, Peter M Hawkey
BACKGROUND: Staphylococci are a major constituent of the nasal microbiome and a frequent cause of hospital-acquired infection. Antibiotic surgical prophylaxis is administered prior to surgery to reduce a patient's risk of postoperative infection. The impact of surgical prophylaxis on the nasal staphylococcal microbiome is largely unknown. Here, we report the species present in the nasal staphylococcal microbiome and the impact of surgical prophylaxis revealed by a novel culture independent technique...
December 2, 2016: Microbiome
https://www.readbyqxmd.com/read/27896598/bacterial-and-fungal-biofilm-formation-on-anodized-titanium-alloys-with-fluorine
#8
Concepcion Perez-Jorge, Maria-Angeles Arenas, Ana Conde, Juan-Manuel Hernández-Lopez, Juan-Jose de Damborenea, Steve Fisher, Alessandra M Agostinho Hunt, Jaime Esteban, Garth James
Orthopaedic device-related infections are closely linked to biofilm formation on the surfaces of these devices. Several modified titanium (Ti-6Al-4V) surfaces doped with fluorine were studied in order to evaluate the influence of these modifications on biofilm formation by Gram-positive and Gram-negative bacteria as well as a yeast. The biofilm studies were performed according to the standard test method approved by ASTM (Designation: E2196-12) using the Rotating Disk Reactor. Four types of Ti-6Al-4V samples were tested; chemically polished (CP), two types of nanostructures containing fluorine, nanoporous (NP) and nanotubular (NT), and non-nanostructured fluorine containing samples (fluoride barrier layers, FBL)...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27896496/dalbavancin-reduces-biofilms-of-methicillin-resistant-staphylococcus-aureus-mrsa-and-methicillin-resistant-staphylococcus-epidermidis-mrse
#9
D Knafl, S Tobudic, S C Cheng, D R Bellamy, F Thalhammer
Activity of dalbavancin against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) in biofilm was investigated and the microbicidal biofilm concentrations (MBC) were determined. Biofilms obtained from ten MRSA and ten MRSE bloodstream isolates, collected from patients in the General Hospital of Vienna between 2012 and 2015, were incubated with dalbavancin in trypticase soy broth (TSB) in serial dilution from 0.0625 mg/l to 256 mg/l using a microtiter plate biofilm model...
November 28, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27894388/-analysis-of-distribution-and-drug-resistance-of-pathogens-isolated-from-541-hospitalized-children-with-burn-infection
#10
J X Dai, L Li, L Xu, Z H Chen, X Y Li, M Liu, Y Q Wen, X D Chen
Objective: To investigate the distribution and drug resistance of pathogens isolated from hospitalized children with burn infection. Methods: Totally 541 patients were hospitalized in Fujian Medical University Union Hospital, the 180th Hospital of Chinese People's Liberation Army(PLA), the 92th Hospital of PLA, and Longyan First Hospital from January 2013 to December 2015. Totally 848 clinical specimens (blood, catheter tip attachments, wound exudate, etc.) were collected for pathogen detection. After being identified by an automatic microbiological identification system, drug resistance of pathogens to 41 commonly-used antibiotics in clinic including gentamicin, aztreonam, erythromycin, clindamycin, etc...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27890783/the-proline-glycine-rich-region-of-the-biofilm-adhesion-protein-aap-forms-an-extended-stalk-that-resists-compaction
#11
Alexander E Yarawsky, Lance R English, Steven T Whitten, Andrew B Herr
Staphylococcus epidermidis is one of the primary bacterial species responsible for healthcare-associated infections. The most significant virulence factor for S. epidermidis is its ability to form a biofilm, which renders the bacteria highly resistant to host immune responses and antibiotic action. Intercellular adhesion within the biofilm is mediated by the accumulation-associated protein (Aap), a cell wall-anchored protein that self-assembles in a zinc-dependent manner. The C-terminal portion of Aap contains a proline/glycine-rich, 135 amino acid-long region that has not yet been characterized...
November 24, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27890233/establishing-tolerance-to-commensal-skin-bacteria-timing-is-everything
#12
REVIEW
Tiffany C Scharschmidt
Commensal bacteria live intimately and in constant dialogue with skin immune cells. Regulating our immune response to these bacteria is critical for skin homeostasis. Using a new murine model to track Staphylococcus epidermidis-specific T cells, we found that colonization during neonatal but not adult life led to S.epidermidis-specific immune tolerance. This tolerance protected against skin inflammation and was mediated by a wave of regulatory T cells entering neonatal skin. These findings provide new insight into how we establish a healthy symbiosis with commensal microbes and highlight avenues for future research to identify novel therapies for inflammatory skin disease...
January 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/27887598/comparison-of-the-most-common-isolates-of-postoperative-endophthalmitis-in-south-korea-enterococcus-species-vs-coagulase-negative-staphylococci
#13
Ki Yup Nam, Hyun Wong Kim, Woo Jin Jeung, Jung Min Park, Jong Moon Park, In Young Chung, Yong Seop Han, Bu Sup Oum, Ji Eun Lee, Ik Soo Byon, Il Han Yun, Joo Eun Lee, Hee Sung Yoon, Dong Park, Byeng Chul Yu, Sang Joon Lee
BACKGROUND: To compare the related factors or manifestations of the two most common isolates of post-operative endophthalmitis, which were Enterococcus spp. and coagulase-negative staphylococci (CNS) in South Korea. METHODS: Medical records were reviewed for cases of post-operative endophthalmitis caused by Enterococcus spp. and CNS at eight institutions between January 2004 and July 2010. Various factors including age, sex, residence, systemic diseases, smoking and drinking history, and best corrected visual acuity, and length of time between causative intraocular surgery and symptom development were compared between the two groups...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27886094/damxungmacin-a-and-b-two-new-amicoumacins-with-rare-heterocyclic-cores-isolated-from-bacillus-subtilis-xz-7
#14
Hui-Ling Tang, Cheng-Hang Sun, Xin-Xin Hu, Xue-Fu You, Min Wang, Shao-Wei Liu
Two new amicoumacins, named Damxungmacin A (1) and B (2), were isolated from the culture broth of a soil-derived bacterium Bacillus subtilis XZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound 1 possessed a 1,4-diazabicyclo[2.2.1]heptane-2-one ring system in its structure, which was reported for the first time, while 2 had a 1-acetylmorpholine-3-one moiety, which was naturally rare. Compound 1 exhibited moderate to weak cytotoxic activities against three human tumor cell lines (A549, HCT116 and HepG2) with IC50 values of 13...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27885394/sports-specific-differences-in-postsurgical-infections-after-arthroscopically-assisted-anterior-cruciate-ligament-reconstruction
#15
Werner Krutsch, Johannes Zellner, Florian Zeman, Michael Nerlich, Matthias Koch, Christian Pfeifer, Peter Angele
PURPOSE: Post-operative infection after arthroscopically assisted anterior cruciate ligament (ACL) reconstruction is a rare but severe complication, particularly for young and active patients. It is unclear whether the prevalence of knee infection is correlated with the type of sports or the level of performance. METHODS: From 2008 to 2012, the internal single-centre ACL registry of the FIFA Medical Centre of Excellence Regensburg was retrospectively screened for sex, age, time between isolated primary ACL rupture and surgery, surgical technique, rate of infection after ACL reconstruction and the type of sports practised...
November 24, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27884340/use-of-an-experimental-model-to-evaluate-infection-resistance-of-meshes-in-abdominal-wall-surgery
#16
Ramón Pérez-Tanoira, C Lévano-Linares, Á Celdrán-Uriarte, M C Isea-Peña, M Sánchez De Molina, C García-Vasquez, J Esteban-Moreno
BACKGROUND: Staphylococcal species are the most common organisms causing prosthetic mesh infections, however, infections due to rapidly growing mycobacteria are increasing. This study evaluates the resistance of biomaterial for abdominal wall prostheses against the development of postoperative infection in a rat model. MATERIAL AND METHODS: In 75 rats, we intramuscularly implanted three different types of prostheses: (1) low-density polypropylene monofilament mesh (PMM), (2) high-density PMM, and (3) a composite prosthesis composed of low-density PMM and a nonporous hydrophilic film...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27877157/cross-talk-between-staphylococcus-aureus-and-other-staphylococcal-species-via-the-agr-quorum-sensing-system
#17
Jaime Canovas, Mara Baldry, Martin S Bojer, Paal S Andersen, Piotr K Grzeskowiak, Marc Stegger, Peter Damborg, Christian A Olsen, Hanne Ingmer
Staphylococci are associated with both humans and animals. While most are non-pathogenic colonizers, Staphylococcus aureus is an opportunistic pathogen capable of causing severe infections. S. aureus virulence is controlled by the agr quorum sensing system responding to secreted auto-inducing peptides (AIPs) sensed by AgrC, a two component histidine kinase. agr loci are found also in other staphylococcal species and for Staphylococcus epidermidis, the encoded AIP represses expression of agr regulated virulence genes in S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27876296/pathogenic-features-of-clinically-significant-coagulase-negative-staphylococci-in-hospital-and-community-infections-in-benin
#18
Chimène Nanoukon, Xavier Argemi, Frédéric Sogbo, Jeanne Orekan, Daniel Keller, Dissou Affolabi, Frédéric Schramm, Philippe Riegel, Lamine Baba-Moussa, Gilles Prévost
In West Africa, very little consideration has been given to coagulase negative Staphylococci (CNS). Herein, we describe the features contributing to the pathogenicity of 99 clinically-significant independent CNS isolates associated with infections encountered at the National Teaching Hospital Center of Cotonou (Benin). The pathogenic potentials of nosocomial strains were compared with community strains. S. haemolyticus (44%), S. epidermidis (22%) and S. hominis (7%) were the most frequently isolated while bacteremia (66...
November 10, 2016: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/27873736/amber-necklaces-reasons-for-use-and-awareness-of-risk-associated-with-bacterial-colonisation
#19
Pauline Machet, Philippe Lanotte, Bruno Giraudeau, Marie Leperlier, Elsa Tavernier, Annabel Maruani
BACKGROUND: Parents are increasingly placing amber necklaces on their infants or toddlers to prevent teething pain. The use of the necklaces can pose a risk of death by strangulation, however, there are no data on the potential infectious risk linked to bacterial colonisation associated with the necklaces. OBJECTIVES: We aimed to analyse bacterial colonisation of amber necklaces worn by children during hospital consultations. MATERIAL & METHODS: This prospective observational study included all children wearing a teething necklace at consultation in the Paediatric Dermatology and the Paediatric Emergency Department of our hospital from April to December 2014...
November 21, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27872722/production-of-monoclonal-antibody-against-recombinant-ns3-protein-of-bovine-viral-diarrhea-virus-nadl-strain
#20
Masood Reza Seyfi Abad Shapouri, Maryam Ekhtelat, Masood Ghorbanpoor Najaf Abadi, Mohsen Lotfi, Mohamad Rashno
This study was conducted to investigate the prevalence of subclinical mastitis caused by Staphylococcus spp. in ewes in West-Azerbaijan province of Iran. Molecular characterization of isolated Staphylococcus spp. from diseased ewes were performed using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) and DNA sequencing of glyceraldehyde-3-phosphate dehydrogenase (gap) gene. Also, antibiotic resistance of staphylococcal isolates against different antibiotics was investigated...
2016: Veterinary Research Forum
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