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https://www.readbyqxmd.com/read/28805046/electroenhanced-antimicrobial-coating-based-on-conjugated-polymers-with-covalently-coupled-silver-nanoparticles-prevents-staphylococcus-aureus-biofilm-formation
#1
Salvador Gomez-Carretero, Rolf Nybom, Agneta Richter-Dahlfors
The incidence of hospital-acquired infections is to a large extent due to device-associated infections. Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP-based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT-MeOH:PSS) and (3-aminopropyl)triethoxysilane is designed...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28803570/decontamination-of-an-extracorporeal-membrane-oxygenator-contaminated-with-mycobacterium-chimaera
#2
Mark I Garvey, Natalie Phillips, Craig W Bradley, Elisabeth Holden
Water samples taken from extracorporeal membrane oxygenator (ECMO) devices used at University Hospitals Birmingham yielded high total viable counts (TVCs) containing a variety of microorganisms, including M. chimaera. Disinfection resulted in the reduction of TVCs and eradication of Mycobacterium chimaera. Weekly disinfection and water sampling are required to manage the water quality in these devices. Infect Control Hosp Epidemiol 2017;1-3.
August 14, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28803214/self-defensive-antibiotic-loaded-layer-by-layer-coatings-imaging-of-localized-bacterial-acidification-and-ph-triggering-of-antibiotic-release
#3
Victoria Albright, Iryna Zhuk, Yuhao Wang, Victor Selin, Betsy van de Belt-Gritter, Henk J Busscher, Henny C van der Mei, Svetlana Sukhishvili
Self-defensive antibiotic-loaded coatings have shown promise in inhibiting growth of pathogenic bacteria adhering to biomaterial implants and devices, but direct proof that their antibacterial release is triggered by bacterially-induced acidification of the immediate environment under buffered conditions remained elusive. Here, we demonstrate that Staphylococcus aureus and Escherichia coli adhering to such coatings generate highly localized acidification, even in buffered conditions, to activate pH-triggered, self-defensive antibiotic release...
August 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28801691/a-new-data-processing-routine-facilitating-the-identification-of-surface-adhered-proteins-from-bacterial-conditioning-films-via-qcm-d-maldi-tof-ms
#4
Siegfried Hohmann, Anke Neidig, Boris Kühl, Frank Kirschhöfer, Jörg Overhage, Gerald Brenner-Weiß
Conditioning films are an important factor in the initiation and development of microbial biofilms, which are the leading cause of chronic infections associated with medical devices. Here, we analyzed the protein content of conditioning films formed after exposure to supernatants of cultures of the human pathogen Pseudomonas aeruginosa PAO1. Adhesion of substances from the supernatant was monitored using quartz crystal microbalance with dissipation monitoring (QCM-D) sensor chips modified with the commonly used implant material titanium dioxide (TiO2)...
August 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28800517/efficient-inactivation-of-ms-2-virus-in-water-by-hydrodynamic-cavitation
#5
Janez Kosel, Ion Gutiérrez-Aguirre, Nejc Rački, Tanja Dreo, Maja Ravnikar, Matevž Dular
The aim of this study was to accurately quantify the impact of hydrodynamic cavitation on the infectivity of bacteriophage MS2, a norovirus surrogate, and to develop a small scale reactor for testing the effect of hydrodynamic cavitation on human enteric viruses, which cannot be easily prepared in large quantities. For this purpose, 3 mL scale and 1 L scale reactors were constructed and tested. Both devices were efficient in generating hydrodynamic cavitation and in reducing the infectivity of MS2 virus. Furthermore, they reached more than 4 logs reductions of viral infectivity, thus confirming the scalability of hydrodynamic cavitation for this particular application...
July 31, 2017: Water Research
https://www.readbyqxmd.com/read/28798366/elevated-serum-antibody-against-schistosoma-japonicum-hsp60-as-a-promising-biomarker-for-liver-pathology-in-schistosomiasis
#6
Xiaojun Chen, Wei Li, Yalin Li, Lei Xu, Sha Zhou, Jifeng Zhu, Zhipeng Xu, Feng Liu, Dandan Lin, Fei Hu, Yuemin Liu, Wen Jiang, Liwang Cui, Chuan Su
The pathology associated with Schistosoma japonicum (S. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. Currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used on a large scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is lacking. The levels of serum S. japonicum heat shock protein 60 (SjHSP60)-specific IgG and its subtype antibodies in animals (mice and rabbits) or patients with schistosomiasis were measured by ELISA...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794175/a-comparative-genomics-study-of-staphylococcus-epidermidis-from-orthopedic-device-related-infections-correlated-with-patient-outcome
#7
Virginia Post, Llinos G Harris, Mario Morgenstern, Leonardos Mageiros, Matthew D Hitchings, Guillaume Méric, Ben Pascoe, Samuel K Sheppard, R Geoff Richards, T Fintan Moriarty
Staphylococcus epidermidis has emerged as an important opportunistic pathogen causing orthopedic device-related infections (ODRIs). This study investigated the association of genome variation and phenotypic features of the infecting S. epidermidis isolate with the clinical outcome of the infected patient. S. epidermidis isolates were collected from 104 patients with ODRI. Their clinical outcome was evaluated, after an average of 26 months, as either "cured" or "not cured". The isolates were tested for antibiotic susceptibility and biofilm formation...
August 9, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28792118/rna-mediated-signal-perception-in-pathogenic-bacteria
#8
REVIEW
Dmitriy Ignatov, Jörgen Johansson
Bacterial pathogens encounter several different environments during an infection, many of them possibly being detrimental. In order to sense its surroundings and adjust the gene expression accordingly, different regulatory schemes are undertaken. With these, the bacterium appropriately can differentiate between various environmental cues to express the correct virulence factor at the appropriate time and place. An attractive regulator device is RNA, which has an outstanding ability to alter its structure in response to external stimuli, such as metabolite concentration or alterations in temperature, to control its downstream gene expression...
August 9, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28791329/clinical-impact-of-eus-treatment-of-walled-off-pancreatic-necrosis-with-dedicated-devices
#9
Ilaria Tarantino, Dario Ligresti, Fabio Tuzzolino, Luca Barresi, Gabriele Curcio, Antonino Granata, Mario Traina
BACKGROUND AND STUDY AIMS:  Walled-off pancreatic necrosis (WOPN) represents the major risk factor for sepsis-related multiple organ failure. Surgical debridement is an invasive approach associated with high rates of adverse events (AEs) and death. As an alternative, endoscopic ultrasound-guided cysto-gastro-anastomosis has emerged as an effective treatment for WOPNs. Recently a new dedicated-lumen apposing metal stent (LAMS) has been used with satisfactory results in treating peri-pancreatic fluid collections, including WOPNs...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28790779/device-associated-healthcare-associated-infections-da-hai-and-the-caveat-of-multiresistance-in-a-multidisciplinary-intensive-care-unit
#10
Inam Danish Khan, Atoshi Basu, Sheshadri Kiran, Shaleen Trivedi, Priyanka Pandit, Anupam Chattoraj
BACKGROUND: Device-Associated Healthcare-Associated Infections (DA-HAI), including Ventilator-Associated Pneumonia (VAP), Central-Line-Associated Blood Stream Infection (CLABSI), and Catheter-Related Urinary Tract Infection (CAUTI), are considered as principal contributors to healthcare hazard and threat to patient safety as they can cause prolonged hospital stay, sepsis, and mortality in the ICU. The study intends to characterize DA-HAI in a tertiary care multidisciplinary ICU of a teaching hospital in eastern India...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28790042/multicentre-randomised-controlled-trial-to-investigate-the-usefulness-of-continuous-pneumatic-regulation-of-tracheal-cuff-pressure-for-reducing-ventilator-associated-pneumonia-in-mechanically-ventilated-severe-trauma-patients-the-agate-study-protocol
#11
Nicolas Marjanovic, Denis Frasca, Karim Asehnoune, Catherine Paugam, Sigismond Lasocki, Carole Ichai, Jean-Yves Lefrant, Marc Leone, Claire Dahyot-Fizelier, Julien Pottecher, Dominique Falcon, Benoit Veber, Jean-Michel Constantin, Sabrina Seguin, Jérémy Guénézan, Olivier Mimoz
INTRODUCTION: Severe trauma represents the leading cause of mortality worldwide. While 80% of deaths occur within the first 24 hours after trauma, 20% occur later and are mainly due to healthcare-associated infections, including ventilator-associated pneumonia (VAP). Preventing underinflation of the tracheal cuff is recommended to reduce microaspiration, which plays a major role in the pathogenesis of VAP. Automatic devices facilitate the regulation of tracheal cuff pressure, and their implementation has the potential to reduce VAP...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28782933/new-insights-into-antibiofilm-effect-of-a-nano-sized-zno-coating-against-the-pathogenic-methicillin-resistant-staphylococcus-aureus
#12
Marta M Alves, Ons Bouchami, Ana Tavares, Laura Córdoba, Catarina Ferreira Santos, Maria Miragaia, Maria de Fatima Montemor
ZnO nanoparticles (NPs) are arising as promising novel antibiotics towards device-related infections. The surface functionalization of Zn, a novel resorbable biomaterial, with ZnO NPs could present an effective solution to overcome such threat. In this sense, the antibacterial and antibiofilm activity of nano and micro-sized ZnO coatings was studied against clinically relevant bacteria - methicillin resistant Staphylococcus aureus (MRSA). The bacterial viability of planktonic and biofilm cells together with the corresponding biofilms structures revealed that only the nano-sized ZnO coating had an antibiofilm effect...
August 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28782724/zwitterionic-sulfobetaine-polymer-immobilized-surface-by-simple-tyrosinase-mediated-grafting-for-enhanced-antifouling-property
#13
Ho Joon Kwon, Yunki Lee, Le Thi Phuong, Gyeung Mi Seon, Eunsuk Kim, Jong Chul Park, Hyunjin Yoon, Ki Dong Park
Introducing antifouling property to biomaterial surfaces has been considered an effective method for preventing the failure of implanted devices. In order to achieve this, the immobilization of zwitterions on biomaterial surfaces has been proven to be an excellent way of improving anti-adhesive potency. In this study, poly(sulfobetaine-co-tyramine), a tyramine-conjugated sulfobetaine polymer, was synthesized and simply grafted onto the surface of polyurethane via a tyrosinase-mediated reaction. Surface characterization by water contact angle measurements, X-ray photoelectron spectroscopy and atomic force microscopy demonstrated that the zwitterionic polymer was successfully introduced onto the surface of polyurethane and remained stable for 7days...
August 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28782183/pectin-nanocoating-reduces-proinflammatory-fibroblast-response-to-bacteria
#14
A Mieszkowska, J Folkert, T Gaber, K Miksch, K Gurzawska
Implant failures are primarily related to bacterial infections and inflammation. Nanocoating of implant devices with organic molecules is a method used for improving their integration into host tissues and limiting inflammation. Bioengineered plant-derived rhamnogalacturonan-Is (RG-Is) from pectins improve tissue regeneration and exhibit anti-inflammatory properties. Therefore, the aim of this study is to evaluate the in vitro effect of RG-I nanocoating on human gingival primary fibroblast (HGF) activity and proinflammatory response following Porphyromonas gingivalis (P...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28781994/rapid-antibiotic-sensitivity-testing-in-microwell-arrays
#15
Fatemeh Jalali, Felix Ellett, Daniel Irimia
The widespread bacterial resistance to a broad range of antibiotics necessitates rapid antibiotic susceptibility testing before effective treatment could start in the clinic. Among resistant bacteria, Staphylococcus aureus is one of the most important, and Methicillin-resistant (MRSA) strains are a common cause of life threatening infections. However, standard susceptibility testing for S. aureus is time consuming and thus the start of effective antibiotic treatment is often delayed. To circumvent the limitations of current susceptibility testing systems, we designed an assay that enables measurements of bacterial growth with higher spatial and temporal resolution than standard techniques...
June 2017: Technology
https://www.readbyqxmd.com/read/28780309/clinical-and-microbiological-characteristics-of-pantoea-agglomerans-infection-in-children
#16
Ayşe Büyükcam, Özlem Tuncer, Deniz Gür, Banu Sancak, Mehmet Ceyhan, Ali Bülent Cengiz, Ateş Kara
Pantoea agglomerans is an environmental Gram-negative bacterium that rarely is responsible for the infections in humans but it is often a causative factor of a number of occupational diseases. This study evaluated the clinical and microbiological characteristics and pathogenicity of P. agglomerans in children. We retrospectively reviewed microbiological test results for all children (1 month old to 18 years old) who were admitted to our pediatric hospital between January 2000 to June 2015 and had positive clinical specimen cultures for P...
August 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28780036/transcatheter-tricuspid-valve-repair-with%C3%A2-a-new-transcatheter-coaptation-system-for-the-treatment-of-severe-tricuspid-regurgitation-1-year-clinical-and-echocardiographic-results
#17
Gidon Perlman, Fabien Praz, Rishi Puri, Hadass Ofek, Jian Ye, Francois Philippon, Thierry Carrel, Philippe Pibarot, Adrian Attinger, Nay Min Htun, Danny Dvir, Robert Moss, Francisco Campelo-Parada, Elisabeth Bédard, David Reineke, Aris Moschovitis, Sandra Lauck, Philipp Blanke, Jonathon Leipsic, Stephan Windecker, Josep Rodés-Cabau, John Webb
OBJECTIVES: This study sought to describe the 1-year experience with the transcatheter FORMA system for severe tricuspid regurgitation (TR). BACKGROUND: Severe TR is associated with significant morbidity and mortality. Novel transcatheter therapies have been recently developed. METHODS: Eighteen patients underwent device implantation at 3 centers in Canada and Switzerland. Baseline characteristics, procedural, 30-day, and 1-year outcomes were prospectively evaluated using multimodality imaging and hemodynamic and clinical assessments...
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28777541/uv-curable-contact-active-benzophenone-terminated-quaternary-ammonium-antimicrobials-for-applications-in-polymer-plastics-and-related-devices
#18
Lukas Porosa, Alexander Caschera, Amanda Mocella, Joseph Bedard, Evan Ronan, Alan J Lough, Gideon Wolfaardt, Daniel Foucher
A series of UV active benzophenone ([C6H5COC6H4-O-(CH2)n-N+Me2R][X-], 4: R = C12H25, n = 3, X- = Br- , 5a-c: R = C18H37, n = 3, X- = Cl-, Br-, I-; 6a-c: R = C18H37, n = 4, X- = Cl-, Br-, I- ; 7a-c: R = C18H37, n = 6, X- = Cl-, Br-, I-) terminated C12 and C18 quaternary ammonium salts (QACs) were prepared by thermal or microwave driven Menshutkin protocols of the appropriate benzophenone alkyl halide (1a-c, 2a-c, 3a-c) with the corresponding dodecyl- or octadecyl N,N-dimethylamine. All new compounds were characterized by NMR spectroscopy, HRMS spectrometry and in one instance (4) by single crystal X-ray crystallography...
August 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28777409/potential-role-of-a-subcutaneously-anchored-securement-device-in-preventing-dislodgment-of-tunneled-cuffed-central-venous-devices-in-pediatric-patients
#19
Andrea Dolcino, Antonio Salsano, Andrea Dato, Nicola Disma, Alessio Pini Prato, Filippo Bernasconi, Luigi Montagnini, Stefano Avanzini, Michela Bevilacqua, Giovanni Montobbio, Girolamo Mattioli, Clelia Zanaboni
INTRODUCTION: The potential drawbacks of tunneled-cuffed catheters are complications such as local or systemic infection, dislodgment, rupture, malfunction, and deep venous thrombosis. Aim of this study is to describe the incidence of complications, focusing on dislodgment and on the role of new securement devices in reducing this annoying issue. METHODS: We enrolled all pediatric patients with tunneled-cuffed central venous catheters (CVCs) inserted at the Giannina Gaslini Institute during a 16-month period...
August 27, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28777392/long-term-follow-up-of-continuous-flow-left-ventricular-assist-devices-complications-and-predisposing-risk-factors
#20
Tolulope A Adesiyun, Rhondalyn C McLean, Ryan J Tedford, Glenn J R Whitman, Chris M Sciortino, John V Conte, Ashish S Shah, Stuart D Russell
PURPOSE: To assess LVAD complications and their overall effect on mortality and determine factors associated with development of early and long-term complications. METHODS: A retrospective cohort study of patients who underwent continuous flow LVAD placement between January 1, 2000 and November 30, 2013 was performed. The incidence of complications (sepsis or bacteremia, driveline infections, gastrointestinal bleeding, pump thrombosis, cerebrovascular accidents and anemia requiring transfusion) was collected and logistic regression and Cox proportional hazards analyses were performed...
August 2, 2017: International Journal of Artificial Organs
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