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https://www.readbyqxmd.com/read/28646435/eco-friendly-synthesis-of-silver-nanoparticles-using-green-algae-caulerpa-serrulata-reaction-optimization-catalytic-and-antibacterial-activities
#1
Eman F Aboelfetoh, Rania A El-Shenody, Mohamed M Ghobara
Stable colloidal silver nanoparticles (AgNPs) were synthesized using Caulerpa serrulata (green marine algae) aqueous extract as an efficient reducing and stabilizing agent. This method is considered to be a sustainable alternate to the more complicated chemical procedures. To achieve the optimization synthesis of AgNPs, several effects such as extract concentration, contact time, pH values, and temperature were examined. The synthesized AgNPs were characterized by UV-Vis spectroscopy, FT-IR, XRD, and HR-TEM...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28646389/photodynamic-therapy-controls-of-staphylococcus-aureus-intradermal-infection-in-mice
#2
Palloma Porto Almeida, Ítalo Sousa Pereira, Karine Bitencourt Rodrigues, Lorena Santos Leal, Andressa Souza Marques, Luciano Pereira Rosa, Francine Cristina da Silva, Robson Amaro Augusto da Silva
Infections caused by Staphylococcus aureus lead to skin infections, as well as soft tissues and bone infections. Given the communal resistance to antibiotics developed by strains of this bacterium, photodynamic therapy emerges as a promising alternative treatment to control and cure infections. Females of the Balb/C mice were infected with 10(8) CFU of methicillin-resistant S. aureus (MRSA) and divided into four distinct groups: P-L- (negative control group), P+L- (group exposed only to curcumin), P-L+ (group exposed only to LED incidence of 450 nm, 75 mW/cm(2), and 54 J/cm(2) for 10 min), and P+L+ (group exposed to curcumin followed by 10 min of LED irradiation) (n = 24)...
June 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28646206/crispr-cas9-mediated-genome-editing-via-postnatal-administration-of-aav-vector-cures-haemophilia-b-mice
#3
Tsukasa Ohmori, Yasumitsu Nagao, Hiroaki Mizukami, Asuka Sakata, Shin-Ichi Muramatsu, Keiya Ozawa, Shin-Ichi Tominaga, Yutaka Hanazono, Satoshi Nishimura, Osamu Nureki, Yoichi Sakata
Haemophilia B, a congenital haemorrhagic disease caused by mutations in coagulation factor IX gene (F9), is considered an appropriate target for genome editing technology. Here, we describe treatment strategies for haemophilia B mice using the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system. Administration of adeno-associated virus (AAV) 8 vector harbouring Staphylococcus aureus Cas9 (SaCas9) and single guide RNA (sgRNA) to wild-type adult mice induced a double-strand break (DSB) at the target site of F9 in hepatocytes, sufficiently developing haemophilia B...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646114/staphylococcus-aureus-strain-newman-photoinactivation-and-cellular-response-to-sunlight-exposure
#4
Jill S McClary, Lauren M Sassoubre, Alexandria B Boehm
Sunlight influences microbial water quality of surface waters. Previous studies have investigated photoinactivation mechanisms and cellular photostress responses of fecal indicator bacteria (FIB), including Escherichia coli and enterococci, but further work is needed to characterize photostress responses of bacterial pathogens. Here we investigate the photoinactivation of Staphylococcus aureus (strain Newman), a pigmented, waterborne pathogen of emerging concern. We measured photodecay using standard culture-based assays and cellular membrane integrity; and investigated photostress response by measuring the relative number of mRNA transcripts of select oxidative stress, DNA repair, and metabolism genes...
June 23, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28645916/structures-and-dynamics-of-hibernating-ribosomes-from-staphylococcus-aureus-mediated-by-intermolecular-interactions-of-hpf
#5
Iskander Khusainov, Quentin Vicens, Rustam Ayupov, Konstantin Usachev, Alexander Myasnikov, Angelita Simonetti, Shamil Validov, Bruno Kieffer, Gulnara Yusupova, Marat Yusupov, Yaser Hashem
In bacteria, ribosomal hibernation shuts down translation as a response to stress, through reversible binding of stress-induced proteins to ribosomes. This process typically involves the formation of 100S ribosome dimers. Here, we present the structures of hibernating ribosomes from human pathogen Staphylococcus aureus containing a long variant of the hibernation-promoting factor (SaHPF) that we solved using cryo-electron microscopy. Our reconstructions reveal that the N-terminal domain (NTD) of SaHPF binds to the 30S subunit as observed for shorter variants of HPF in other species...
June 23, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28645883/the-first-nationwide-surveillance-of-antibacterial-susceptibility-patterns-of-pathogens-isolated-from-skin-and-soft-tissue-infections-in-dermatology-departments-in-japan
#6
Shinichi Watanabe, Takamitsu Ohnishi, Akira Yuasa, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Akira Watanabe, Junko Sato, Hideaki Hanaki, Motomu Manabe, Tamio Suzuki, Fujio Otsuka, Michiko Aihara, Ken Iozumi, Takeshi Tamaki, Yuichi Funada, Mikio Shinozaki, Motoko Kobayashi, Masaru Okuda, Go Kikyo, Kumi Kikuchi, Yoshitane Okada, Masanori Takeshima, Osamu Kaneko, Natsuki Ogawa, Rie Ito, Ryuhei Okuyama, Shinji Shimada, Tadamichi Shimizu, Naohito Hatta, Maeda Manabu, Kiyohiro Tsutsui, Toshihiro Tanaka, Yoshiki Miyachi, Hideo Asada, Fukumi Furukawa, Ichiro Kurokawa, Keiji Iwatsuki, Michihiro Hide, Masahiko Muto, Osamu Yamamoto, Hiroyuki Niihara, Kenji Takagaki, Yasuo Kubota, Koji Sayama, Shigetoshi Sano, Masutaka Furue, Takuro Kanekura
To investigate the trends of antimicrobial resistance in pathogens isolated from skin and soft-tissue infections (SSTI) at dermatology departments in Japan, a Japanese surveillance committee conducted the first nationwide survey in 2013. Three main organisms were collected from SSTI at 30 dermatology departments in medical centers and 10 dermatology clinics. A total of 860 strains - 579 of Staphylococcus aureus, 240 of coagulase-negative Staphylococci, and 41 of Streptococcus pyogenes - were collected and shipped to a central laboratory for antimicrobial susceptibility testing...
June 20, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28645784/the-effect-of-antimicrobial-photodynamic-therapy-on-the-expression-of-novel-methicillin-resistance-markers-determined-using-cdna-aflp-approach-in-staphylococcus-aureus
#7
Mohammad Neshvan Hoorijani, Hosein Rostami, Maryam Pourhajibagher, Nasim Chiniforush, Mansour Heidari, Babak Pourakbari, Hossein Kazemian, Kambiz Davari, Vahid Amini, Reza Raoofian, Abbas Bahador
BACKGROUND: Widespread methicillin resistant Staphylococcus aureus (MRSA) and absence of effective antimicrobial agents has led to limited therapeutic options for treating MRSA infection. We aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) on the expression of novel identified methicillin resistance markers (NIMRMs) in S. aureus using complementary DNA-Amplified Fragment Length Polymorphism (cDNA-AFLP) approaches to address the therapeutic alternatives for MRSA infections...
June 20, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28645466/the-scottish-enhanced-staphylococcus-aureus-bacteraemia-surveillance-program-the-first-18-months-data-in-children
#8
F Murdoch, J Danial, A K Morris, E Czarniak, J L Bishop, E Glass, L J Imrie
BACKGROUND: National enhanced surveillance of Staphylococcus aureus Bacteraemia (SAB) commenced on the 1(st) of October 2014 to gain a more in-depth understanding of the epidemiology of SAB within Scotland. Children under 16 were analysed separately from adults because previous studies had demonstrated differences in the epidemiology. AIM: The aim was to identify risk factors and patient populations most at risk to allow focused improvement plans to be developed...
June 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28644681/treatment-results-of-corneal-collagen-cross-linking-combined-with-riboflavin-and-440-nm-blue-light-for-bacterial-corneal-ulcer-in-rabbits
#9
Shufang Wei, Cuiying Zhang, Shaoru Zhang, Yanyun Xu, Guoying Mu
PURPOSE: To study the treatment effect of corneal collagen cross-linking (CXL) combined with 440 nm blue light and riboflavin on bacterial corneal ulcer using animal experiments. METHODS: A total of 21 New Zealand white rabbits that developed Staphylococcus aureus corneal ulcer were randomly divided into three groups. Seven rabbits were used as blank control groups; seven rabbits were treated with CXL combined with riboflavin and 440 nm blue light; and seven rabbits were treated with CXL combined with riboflavin and 370 nm ultraviolet A light...
June 23, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28644421/antibacterial-effect-of-a-4x-cu-tio%C3%A2-coating-simulating-acute-periprosthetic-infection-an-animal-model
#10
Andreas Mauerer, Stefanie Stenglein, Stefan Schulz-Drost, Christoph Schörner, Dominic Taylor, Sebastian Krinner, Frank Heidenau, Werner Adler, Raimund Forst
The purpose of our study was to investigate the antibacterial effect of a spacer (Ti6Al4V) coated with 4x Cu-TiO₂ in an animal model simulating an acute periprosthetic infection by Staphylococcus aureus. Ti6Al4 bolts contaminated with Staphylococcus aureus were implanted into the femoral condyle of rabbits (n = 36) divided into 3 groups. After one week in group 1 (control) the bolts were removed without any replacement. In group2 Ti6Al4V bolts with a 4x Cu-TiO₂ coating and in group 3 beads of a gentamicin-PMMA chain were imbedded into the borehole...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28644410/enhanced-antibacterial-activity-of-ent-labdane-derivatives-of-salvic-acid-7%C3%AE-hydroxy-8-17-ent-labden-15-oic-acid-effect-of-lipophilicity-and-the-hydrogen-bonding-role-in-bacterial-membrane-interaction
#11
Javier Echeverría, Alejandro Urzúa, Loreto Sanhueza, Marcela Wilkens
In the present study, the antibacterial activity of several ent-labdane derivatives of salvic acid (7α-hydroxy-8(17)-ent-labden-15-oic acid) was evaluated in vitro against the Gram-negative bacterium Escherichia coli and the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus. For all of the compounds, the antibacterial activity was expressed as the minimum inhibitory concentration (MIC) in liquid media and minimum inhibitory amount (MIA) in solid media. Structure activity relationships (SAR) were employed to correlate the effect of the calculated lipophilicity parameters (logPow) on the inhibitory activity...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28644011/development-of-silver-nanoparticles-decorated-emulsion-templated-hierarchically-porous-poly-1-vinylimidazole-beads-for-water-treatment
#12
Muhammad Ahmad Mudassir, Syed Zajif Hussain, Asma Rehman, Wasif Zaheer, Syeda Tasmia Asma, Asim Jilani, Mohammad Aslam, Haifei Zhang, Tariq Mahmood Ansari, Irshad Hussain
Water, the driver of nature, has always been polluted by the blind hurling of highly toxic contaminants, but human-friendly science continuously been presenting better avenues to help solve these challenging issues. In this connection, the present study introduces novel nanocomposites comprised of emulsion-templated hierarchically porous poly(1-vinylimidazole) beads loaded with the silver nanoparticles generated via an in-situ approach. These nanocomposites have been thoroughly characterized by FTIR, TGA, BET and FESEM...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28642945/nonribosomal-peptide-synthetase-biosynthetic-clusters-of-eskape-pathogens
#13
REVIEW
Andrew M Gulick
Covering: up to 2017.Natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. A subset of natural products is produced by nonribosomal peptide synthetases (NRPSs), a family of large, modular enzymes that function in an assembly line fashion. Because of the pharmaceutical activity of many NRPS products, much effort has gone into the exploration of their biosynthetic pathways and the diverse products they make...
June 23, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28642157/genome-comparisons-of-two-taiwanese-community-associated-methicillin-resistant-staphylococcus-aureus-st59-clones-support-the-multi-origin-theory-of-ca-mrsa
#14
Ye Feng, Hsiu-Ling Chen, Chih-Jung Chen, Chyi-Liang Chen, Cheng-Hsun Chiu
Sequence type (ST) 59 is an epidemic lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Asia. Two ST59 clones are prevalent in Taiwan: the Taiwan clone (TW) causes severe infections, whereas the Asian-Pacific clone (AP) is usually commensal. In this study, we sequenced the genome and transcriptome of the representative strains of these two clones and found their differences to focus on three mobile genetic elements: TW carries SCCmec Type VT, Panton-Valentine leucocidin (PVL)-encoding prophage ΦSa2, whereas AP carries SCCmec Type IV and staphylokinase (SAK)-encoding prophage ΦSa3...
June 19, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28642103/chimeric-analogs-of-human-%C3%AE-defensin-1-and-%C3%AE-defensin-disrupt-pre-established-bacterial-biofilms
#15
Basil Mathew, Sudar Olli, Ankeeta Guru, Ramakrishanan Nagaraj
Antibiofilm activity of several human defensin analogs that have the ability to kill planktonic bacteria, against pre-established biofilms of Escherichia coli MG1655 and Staphylococcus aureus NCTC 8530 were examined. Linear and linear fatty acylated analogs did not show any activity while disulfide constrained analogs disrupted pre-established S. aureus biofilms. Chimeric analogs of human β-defensin 1 and θ-defensin, hBTD-1 and [d]hBTD-1 were highly active against S. aureus biofilms. Among the analogs tested, only the d-enantiomer [d]hBTD-1 showed activity against E...
June 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28642073/synthesis-of-biogenic-ag-pd-core-shell-nanoparticles-having-anti-cancer-anti-microbial-functions
#16
Wafa I Abdel-Fattah, M M Eid, Sh I Abd El-Moez, E Mohamed, Ghareib W Ali
Biogenic Ag@Pd core-shell nanoparticles were greenly synthesized within two plant extracts aiming at enhanced anticancer/bactericidal functions. These functions were verified for the two Pd@Ag biogenic core-shell nanoparticles (BCSnp) with constant Pd to several Ag contents. BCSnp were synthesized within two extracts of Almond nuts and Black Berry fruits, four samples each, through simple, low cost and echo friendly microwave route. The BCSnp Surface Plasmon Resonance (SPR) was detected via UV/visible spectrophotometer...
June 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/28641931/transfer-of-antibiotic-resistance-in-staphylococcus-aureus
#17
REVIEW
Jakob Haaber, José R Penadés, Hanne Ingmer
Staphylococcus aureus is a serious human pathogen with remarkable adaptive powers. Antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance genes from other S. aureus strains or even from other genera. Transfer is mediated by a diverse complement of mobile genetic elements and occurs primarily by conjugation or bacteriophage transduction, with the latter traditionally being perceived as the primary route. Recent work on conjugation and transduction suggests that transfer by these mechanisms may be more extensive than previously thought, in terms of the range of plasmids that can be transferred by conjugation and the efficiency with which transduction occurs...
June 19, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28641915/the-antimicrobial-spectrum-of-xeroform-%C3%A2
#18
David J Barillo, Anthony R Barillo, Sarah Korn, Kan Lam, Paul S Attar
INTRODUCTION/BACKGROUND: Xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. Bismuth, similar to other metals, has antimicrobial properties. Xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. Despite this, the antimicrobial spectrum of Xeroform(®) remains largely unknown. We examined the in-vitro efficacy of Xeroform(®) against common burn pathogens using zone-of-inhibition methodology in a commercial research facility...
June 19, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28641565/d-amino-acid-analogues-of-the-antimicrobial-peptide-cdt-exhibit-anti-cancer-properties-in-a549-a-human-lung-adenocarcinoma-cell-line
#19
Deborah L Heyl, Hedeel Guy Evans, Jeff Guthrie, Murali Jujjavarapu, Nathan Hendrickson, Anna Eitel, Yeji Park, Jennifer Garvey, Rebecca Newman, Daniel Esckilsen
The importance of the antitumor activity of some antimicrobial peptides is being increasingly recognized. The antimicrobial peptide, tachyplesin, has been shown to exhibit anticancer properties and a linear, cysteine deleted analogue (CDT), was found to retain its antibacterial function. We used sequence reversal and D-amino acids to synthesize four CDT analogues. We found that D-CDT exhibited the best bactericidal properties with the highest selectivity index. While the MIC was found to improve only modestly against S...
June 20, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28641525/1-1%C3%AA-carbonyldiimidazole-cdi-mediated-facile-synthesis-structural-characterization-antimicrobial-activity-and-in-silico-studies-of-coumarin-3-carboxamide-derivatives
#20
Uzma Salar, Khalid Mohammed Khan, Muhammad Imran Fakhri, Shafqat Hussain, Saima Tauseef, Shagufta Ameer, Abdul Wadood, Huma Khan, Shahnaz Perveen
BACKGROUND: Despite of the availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. So, identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. METHOD: To explore the antimicrobial activity of coumarin-3-carboxamides for a range of bacterial and fungal strains, twenty eight derivatives were synthesized by the reaction of coumarin-3-carboxylic acid with a variety of aniline derivatives in the presence of 1,1ꞌ-carbonyldiimidazole (CDI)...
June 22, 2017: Medicinal Chemistry
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