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Gastroesophagic junction cancer

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https://www.readbyqxmd.com/read/28209106/gastroesophageal-junction-and-gastroesophageal-junction-carcinoma%C3%A2-a-short-update
#1
REVIEW
K A Ekmektzoglou, P Apostolopoulos, G Samelis, G Alexandrakis
Cancer of the gastroesophageal junction (GEJ), although rare, is now considered a separate entity with a distinct pathophysiological and molecular profile. Although much progress has been made over the past decades in delineating the multiple environmental and genetic pathways involved GEJ carcinoma, the exact molecular mechanisms underlying disease initiation and progression are still poorly understood. This is of paramount importance for the treating physician as the disease bears a poor therapeutic response...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28187044/minimally-invasive-versus-open-esophageal-resection-three-year-follow-up-of-the-previously-reported-randomized-controlled-trial-the-time-trial
#2
Jennifer Straatman, Nicole van der Wielen, Miguel A Cuesta, Freek Daams, Josep Roig Garcia, Luigi Bonavina, Camiel Rosman, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Donald L van der Peet
OBJECTIVE: The aim of this study was to investigate 3-year survival following a randomized controlled trial comparing minimally invasive with open esophagectomy in patients with esophageal cancer. BACKGROUND: Research on minimally invasive esophagectomy (MIE) has shown faster postoperative recovery and a marked decrease in pulmonary complications. Debate is ongoing as to whether the procedure is equivalent to open resection regarding oncologic outcomes. The study is a follow-up study of the TIME-trial (traditional invasive vs minimally invasive esophagectomy, a multicenter, randomized trial)...
February 9, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28165839/targeting-vegfr-2-in-metastatic-gastric-cancer-results-from-a-literature-based-meta-analysis
#3
Giandomenico Roviello, Karol Polom, Franco Roviello, Daniele Marrelli, Andrea Giovanni Multari, Giovanni Paganini, Chiara Pacifico, Daniele Generali
Angiogenesis is a key process in cancer development. We performed a meta-analysis to assess the efficacy and safety of the novel VEGFR-2 inhibitors in patients with metastatic gastric and gastroesophageal junction cancer. A literature-based meta-analysis of randomized controlled trials (RCTs) was undertaken. The primary outcome was the overall survival. The pooled analysis from RCTs on anti-VEGFR-2 inhibitors revealed a significant increase in overall survival (hazard ratio for death: 0.69, 95% confidence interval: 0...
February 6, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28124769/prevalence-of-her2-positivity-and-its-clinicopathological-correlation-in-locally-advanced-metastatic-gastric-cancer-patients-in-malaysia
#4
Pathmanathan Rajadurai, Ho Kean Fatt, Foo Yoke Ching
PURPOSE: Human epidermal growth factor receptor 2 (Erbb2/HER2) overexpression, which was previously detected in invasive breast cancer, has now been implicated in advanced gastric cancer (GC) and gastroesophageal junction cancer (GEC). A study was conducted to determine the rate of HER2 positivity in patients with locally advanced or metastatic GC and GEC in Malaysia and to assess the impact of various demographic and clinical parameters on HER2 positivity. METHODS: A total of 228 adult patients with GC or GEC were enrolled from Subang Jaya Medical Centre, Malaysia, for retrospective (210) and prospective study...
January 26, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28061474/tomotherapy-as-an-adjuvant-treatment-for-gastroesophageal-junction-and-stomach-cancer-may-reduce-bowel-and-bone-marrow-toxicity-compared-to-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#5
Xin Wang, Yuan Tian, Yuan Tang, Zhi-Hui Hu, Jia-Jia Zhang, Gui-Shan Fu, Pan Ma, Hua Ren, Tao Zhang, Ning Li, Wen-Yang Liu, Hui Fang, Ye-Xiong Li, Jing Jin
PURPOSE: To compare dosimetric parameters of intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and tomotherapy (TOMO) in the adjuvant treatment of gastroesophageal junction (GEJ)/stomach cancer. The planning goal was to maintain high target coverage while keeping the dose to the bowel and bone marrow (BM) as low as possible. MATERIALS AND METHODS: After curative surgery, 16 patients with GEJ/stomach cancer were re-planned by coplanar IMRT (five fixed beam), VMAT (double-arc), and TOMO...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28052652/anti-angiogenic-therapy-in-patients-with-advanced-gastric-and-gastroesophageal-junction-cancer-a-systematic-review
#6
Li-Tzong Chen, Do-Youn Oh, Min-Hee Ryu, Kun-Huei Yeh, Winnie Yeo, Roberto Carlesi, Rebecca Cheng, Jongseok Kim, Mauro Orlando, Yoon-Koo Kang
Despite advancements in therapy for advanced gastric and gastroesophageal junction cancers, their prognosis remains dismal. Tumor angiogenesis plays a key role in cancer growth and metastasis, and recent studies indicate that pharmacologic blockade of angiogenesis is a promising approach to therapy. In this systematic review, we summarize current literature on the clinical benefit of anti-angiogenic agents in advanced gastric cancer. We conducted a systematic search of PubMed and conference proceedings including the American Society of Clinical Oncology, the European Society for Medical Oncology, and the European Cancer Congress...
January 3, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28047261/su-f-t-254-dose-volume-histogram-dvh-analysis-of-breath-hold-vs-free-breathing-techniques-for-esophageal-tumors
#7
R Badkul, K Doke, D Pokhrel, N Aguilera, C Lominska
PURPOSE: Lung and heart doses and associated toxicity are of concern in radiotherapy for esophageal cancer. This study evaluates the dosimetry of deep-inspiration-breath-hold (DIBH) technique as compared to freebreathing(FB) using 3D-conformal treatment(3D-CRT) of esophageal cancer. METHODS: Eight patients were planned with FB and DIBH CT scans. DIBH scans were acquired using Varian RPM system. FB and DIBH CTs were contoured per RTOG-1010 to create the planning target volume(PTV) as well as organs at risk volumes(OAR)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047134/th-cd-202-11-implications-for-online-adaptive-and-non-adaptive-radiotherapy-of-gastic-and-gastroesophageal-junction-cancers-using-mri-guided-radiotherapy
#8
K Mittauer, M Geurts, R Toya, M Bassetti, P Harari, B Paliwal, J Bayouth
PURPOSE: Radiotherapy for gastric and gastroesophageal junction (GEJ) tumors commonly requires large margins due to deformation, motion and variable changes of the stomach anatomy, at the risk of increased normal tissue toxicities. This work quantifies the interfraction variation of stomach deformation from daily MRI-guided radiotherapy to allow for a more targeted determination of margin expansion in the treatment of gastric and GEJ tumors. METHODS: Five patients treated for gastric (n=3) and gastroesophageal junction (n=2) cancers with conventionally fractionated radiotherapy underwent daily MR imaging on a clinical MR-IGRT system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27993812/different-efficacy-of-ramucirumab-in-patients-with-metastatic-gastric-and-gastroesophageal-junction-cancer-according-to-ecog-performance-status
#9
G Roviello, C Pacifico, K Polom, F Roviello, D Generali
No abstract text is available yet for this article.
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27951622/analysis-of-computed-tomographic-findings-according-to-gastroesophageal-flap-valve-grade
#10
Hye Kyung Jeon, Gwang Ha Kim, Nam Kyung Lee, Suk Kim, Bong Eun Lee, Geun Am Song
Background/Aims: The gastroesophageal junction is an important barrier against gastroesophageal ref lux. Endoscopic grading of gastroesophageal f lap valve is simple, reproducible, and may predict reflux activity. We investigated the correlation between gastroesophageal flap valve grade and the gastroesophageal junction's structural properties using abdominal computed tomography. Methods: A total of 138 patients with early gastric cancer who underwent both pre-treatment esophagogastroduodenoscopy and water-distended stomach two-phase computed tomography were enrolled...
December 12, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27932891/trastuzumab-in-the-management-of-gastroesophageal-cancer-patient-selection-and-perspectives
#11
REVIEW
Michael Davidson, Naureen Starling
The addition of trastuzumab to the treatment of a subset of patients with advanced gastric and gastroesophageal junction cancers showing HER2 positivity has been shown to confer clinical benefit; however, questions remain over the optimal methods for defining and selecting such patients. This review provides an overview of current standards for assessing HER2 positivity, the evolving treatment landscape for HER2-positive gastric and esophageal cancers and the challenges and potential future directions in optimal patient selection for HER2-targeted therapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27928799/-impact-of-laparoscopic-surgery-on-efficacy-in-the-treatment-of-gastrointestinal-stromal-tumors-in-different-anatomical-locations
#12
Qingfeng Chen, Jianxian Lin, Chaohui Zheng, Ping Li, Jianwei Xie, Jiabin Wang, Jun Lu, Qiyue Chen, Mi Lin, Longlong Cao, Changming Huang
OBJECTIVE: To investigate the efficacy of laparoscopic surgery in the treatment of gastrointestinal stromal tumors (GIST) in different anatomical locations. METHODS: Clinical data of 133 patients with primary gastric GIST undergoing laparoscopic resection at our department from January 2006 to December 2014 were retrospectively analyzed. These patients were divided into favorable site group (F group, 90 cases), including gastric fundus, anterior wall and greater curvature of gastric body, and unfavorable site group (UF group, 43 cases),including gastroesophageal junction, posterior wall and lesser curvature of gastric body,antrum and pylorus, according to the 2014 version National Comprehensive Cancer Network Clinical Guidelines...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27923357/patient-preferences-for-palliative-treatment-of-locally-advanced-or-metastatic-gastric-cancer-and-adenocarcinoma-of-the-gastroesophageal-junction-a-choice-based-conjoint-analysis-study-from-germany
#13
R Hofheinz, J Clouth, J Borchardt-Wagner, U Wagner, E Weidling, M H Jen, P Brück
BACKGROUND: Decisions on palliative chemotherapy (CT) for locally advanced or metastatic gastric cancer (mGC) require trade-offs between potential benefits and risks for patients. Healthcare providers and payers agree that patient-preferences should be considered. We conducted a choice-based conjoint (CBC) analysis study in pre-treated patients from Germany with mGC or locally advanced or metastatic adenocarcinoma of the gastroesophageal junction (mGEJ-Ca), to evaluate their preferences when hypothetically selecting a CT regimen...
December 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27811508/hospital-of-diagnosis-influences-the-probability-of-receiving-curative-treatment-for-esophageal-cancer
#14
Margreet van Putten, Marijn Koëter, Hanneke W M van Laarhoven, Valery E P P Lemmens, Peter D Siersema, Maarten C C M Hulshof, Rob H A Verhoeven, Grard A P Nieuwenhuijzen
OBJECTIVE: The aim of this article was to study the influence of hospital of diagnosis on the probability of receiving curative treatment and its impact on survival among patients with esophageal cancer (EC). BACKGROUND: Although EC surgery is centralized in the Netherlands, the disease is often diagnosed in hospitals that do not perform this procedure. METHODS: Patients with potentially curable esophageal or gastroesophageal junction tumors diagnosed between 2005 and 2013 who were potentially curable (cT1-3,X, any N, M0,X) were selected from the Netherlands Cancer Registry...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27784452/-second-line-treatment-for-metastatic-or-locally-advanced-gastric-cancer
#15
K C Li, S Y Cheng, J Du, J Li
Gastric cancer is one of the major causes of cancer-related deaths. Many patients with metastatic gastric cancer after first-line chemotherapy received salvage chemotherapy in routine clinical practice. Recent phase Ⅲ trials demonstrated substantial prolongation of overall survival to support this chemotherapy or targeted therapy as a second-line treatment. Both ramucirumab monotherapy and ramucirumab plus paclitaxel were approved by FDA in patients with previously treated advanced gastric or gastroesophageal junction adenocarcinoma...
October 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27778127/race-is-a-risk-for-lymph-node-metastasis-in-patients-with-gastric-cancer
#16
Naruhiko Ikoma, Mariela Blum, Yi-Ju Chiang, Jeannelyn S Estrella, Sinchita Roy-Chowdhuri, Keith Fournier, Paul Mansfield, Jaffer Ajani, Brian D Badgwell
BACKGROUND: The frequency of lymph node metastasis in each T stage of gastric cancer has not been as well described for Western populations as it has for Asian populations. This study aimed to determine these frequencies and to investigate risk factors associated with lymph node metastases in a racially diverse U.S. POPULATION: HASH(0x3dc9bc8) METHODS: A prospectively maintained database of 8260 patients with gastric or gastroesophageal junction adenocarcinoma treated at our institution from 1995 to 2013 was reviewed to identify those who underwent surgical resection without preoperative therapy...
October 24, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27774774/positioning-of-second-line-treatment-for-advanced-gastric-and-gastroesophageal-junction-adenocarcinoma
#17
REVIEW
Carles Pericay, Fernando Rivera, Carlos Gomez-Martin, Inmaculada Nuñez, Alejo Cassinello, Esteban Rodrigo Imedio
Tumors of the upper gastrointestinal tract are increasing in incidence; yet, approaches to the treatment of advanced gastric and/or gastroesophageal junction cancer vary widely, with no internationally agreed first-line regimens. Recent clinical trials have shown that second-line treatment is now possible for selected patients with advanced disease, and current data suggest that the combination of ramucirumab plus paclitaxel may become a standard of care in the second-line setting for metastatic gastric cancer...
December 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27765757/ramucirumab-combined-with-folfox-as-front-line-therapy-for-advanced-esophageal-gastroesophageal-junction-or-gastric-adenocarcinoma-a-randomized-double-blind-multicenter-phase-ii-trial
#18
H H Yoon, J C Bendell, F S Braiteh, I Firdaus, P A Philip, A L Cohn, N Lewis, D M Anderson, E Arrowsmith, J D Schwartz, L Gao, Y Hsu, Y Xu, D Ferry, S R Alberts, Z A Wainberg
BACKGROUND: We report the first randomized, Phase II trial of ramucirumab, an anti-vascular endothelial growth factor receptor-2 monoclonal antibody, as front-line therapy in patients with advanced adenocarcinoma of the esophagus or gastric/gastroesophageal junction (GEJ). PATIENTS AND METHODS: Patients from the USA with advanced esophageal, gastric, or GEJ adenocarcinoma randomly received (1:1) mFOLFOX6 plus ramucirumab (8 mg/kg) or mFOLFOX6 plus placebo every 2 weeks...
December 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27759620/trainee-involvement-in-ivor-lewis-esophagectomy-does-not-negatively-impact-outcomes
#19
Alexander W Phillips, Barry Dent, Maziar Navidi, Arul Immanuel, S Michael Griffin
OBJECTIVE: The aim of the present study was to determine whether trainee involvement in esophageal cancer resection is associated with adverse patient outcomes. BACKGROUND: Operative experience for surgical trainees is under threat. A number of factors have been implicated in this leading to fewer hours for training. Esophagogastric cancer training is particularly vulnerable due to the publication of individual surgeon results and a perception that dual consultant operating improves patient outcomes...
October 17, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27753660/assessment-of-egfr-and-erbb2-her2-in-gastric-and-gastroesophageal-carcinomas-egfr-amplification-is-associated-with-a-worse-prognosis-in-early-stage-and-well-to-moderately-differentiated-carcinoma
#20
Jia-Bin Liao, Huai-Pao Lee, Hsiao-Ting Fu, Herng-Sheng Lee
Epidermal growth factor receptor 1 (EGFR) and erb-b2 receptor tyrosine kinase 2 (ERBB2/HER2) are frequently dysregulated in human cancers. We analyzed EGFR and ERBB2 status in 105 gastric and gastroesophageal junction carcinoma and their clinicopathologic features. For EGFR, 92 (88%) tumors were scored as 0, 2 (2%) as 1+, 7 (7%) as 2+, and 4 (3%) as 3+ by immunohistochemistry (IHC) and 4 (4%) tumors showed EGFR amplification by fluorescence in situ hybridization (FISH). For ERBB2, 90 (86%) tumors were scored as 0, 4 (4%) as 1+, 6 (6%) as 2+, and 5 (5%) as 3+ by IHC and 12 (12%) showed ERBB2 amplification by FISH...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
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