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https://www.readbyqxmd.com/read/29241219/yap-inhibits-the-apoptosis-and-migration-of-human-rectal-cancer-cells-via-suppression-of-jnk-drp1-mitochondrial-fission-htra2-omi-pathways
#1
Haijun Li, Fucheng He, Xin Zhao, Yuan Zhang, Xi Chu, Chunlan Hua, Yunhui Qu, Yu Duan, Liang Ming
BACKGROUND/AIMS: The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence is available concerning its role in cancer cell apoptosis and migration via mitochondrial homeostasis. Here, we identify mitochondrial fission as a regulator of the Hippo-Yap pathway in human rectal cancer tumorigenesis and metastasis. METHODS: In this study, we performed loss-of function assays concerning Yap in RCC via shRNA. Cellular viability and apoptosis were measured via MTT, the TUNEL assay and trypan blue staining...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241196/calycosin-inhibits-the-migration-and-invasion-of-human-breast-cancer-cells-by-down-regulation-of-foxp3-expression
#2
Shuangxi Li, Yafei Wang, Chan Feng, Guoli Wu, Yu Ye, Jing Tian
BACKGROUND/AIMS: Calycosin, a phytoestrogenic compound, has recently emerged as a promising antitumor drug. It has been shown that calycosin suppresses growth and induces apoptosis of breast cancer cells. However, the effect of calycosin on migration and invasion of breast cancer cells and the underlying molecular mechanisms have not been elucidated. METHODS: Human breast cancer cells MCF-7 and T47D were treated with, or without, different doses (0, 6.25, 12.5, 25, 50, 100 or 150 μM) of calycosin, and the viability of different groups was determined by MTT assay...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241073/resveratrol-inhibits-proliferation-migration-and-invasion-via-akt-and-erk1-2-signaling-pathways-in-renal-cell-carcinoma-cells
#3
Yuwan Zhao, Huancheng Tang, Xin Zeng, Dongcai Ye, Jianjun Liu
Recent studies have shown that resveratrol (RES) inhibits cancer cell growth, migration and invasion. Here, we evaluated RES in two human renal cell carcinoma (RCC) cell lines, ACHN and A498. We investigated the effects of RES on proliferation, cell morphology, colony formation, migration, and invasion. We used a proliferation assay to demonstrate that RES inhibited cell growth with IC50 values 132.9±1.064μM in ACHN, and 112.8±1.191μM in A498, respectively. Using inverted contrast microscopy, we showed that RES reduced cell-to-cell contact and inhibited formation of filopodia...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29240449/mir-19-5p-enhances-tumorigenesis-in-human-colorectal-cancer-cells-by-targeting-tspyl5
#4
Chao Huang, Hesheng Luo
The cancer suppressor gene, testis-specific protein Y-encoded-like 5 (TSPYL5), has been implicated in various cancers, including colorectal cancer (CRC). In this study, we investigated the role of TSPYL5 in the development of CRC in vitro. First, we used bioinformatics to predict the binding target of TSPYL5, and found that the microRNA, miR-19-5p, bound to the 3' untranslated region (UTR) of TSPYL5. This interaction was further validated by the dual-luciferase assay. Second, we found that overexpressed TSPYL5 enhanced apoptosis in HT29 cells and reduced cell proliferation, reduced cell migration/invasion, and most of the cells accumulated in the G0/G1 phase of the cell cycle...
December 14, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29239917/natural-compounds-as-epigenetic-regulators-of-human-dendritic-cell-mediated-immune-function
#5
Sheefa Mirza, Kanisha Shah, Shanaya Patel, Nayan Jain, Rakesh Rawal
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and are poised to capture antigen, migrate to draining lymphoid organs, and postmaturation process. Recent evidences have suggested that tumor microenvironment has an effect on DCs by inactivating various components of the immune system responsible for tumor clearance, eventually leading to tumorigenesis. This inactivation is owed to the epigenetic modifications [ie, microRNA (miRNA)] at the posttranscriptional level, thus regulating the differentiation patterns and functional behavior of DCs...
December 12, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29238763/modalities-to-enumerate-circulating-tumor-cells-in-the-bloodstream-for-cancer-prognosis-and-to-monitor-the-response-to-the-therapy
#6
G Romano
Certain malignant cells may detach from the primary tumor and enter the vascular system, forming so-called circulating tumor cells (CTCs). Clusters of malignant cells associated with other cell types can also be observed in the peripheral blood of oncological patients. Such cell clusters are termed circulating tumor microemboli (CTM). The isolation and quantification of CTCs and/or CTM from blood samples allow for an accurate prognosis of the clinical course of the disease and to monitor the response to therapy...
September 2017: Drugs of Today
https://www.readbyqxmd.com/read/29238192/transcriptome-wide-elucidation-of-liposomal-formulations-for-anticancer-drug-delivery
#7
Ying Li, Meng Wang, Bu-Wei Huang, Yuan Ping, Jian You, Jian-Qing Gao
Although widely used in chemotherapy, free doxorubicin (Dox) might enhance cell malignancy undesirably. Liposomal Dox (Doxlipo) has been clinically approved for the treatment of breast cancer due to reduced systematical toxicity and increased tumor targeting, yet the transcriptome-wide elucidation of the Doxlipo formulations remains elusive. To this end, we explored the impact of two Dox liposomal formulations, Doxlipo mainly containing hydrogenated soy phosphatidylcholine or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, on the transcriptional pattern of MCF-7 cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29238081/pyridoxine-5-phosphate-oxidase-is-a-novel-therapeutic-target-and-regulated-by-the-tgf-%C3%AE-signalling-pathway-in-epithelial-ovarian-cancer
#8
Lingyun Zhang, Daibing Zhou, Wencai Guan, Weimin Ren, Wenwen Sun, Jimin Shi, Qunbo Lin, Jinguo Zhang, Tiankui Qiao, Yulong Ye, Yun Wu, Yaning Zhang, Xulei Zuo, Kristin L Connor, Guoxiong Xu
Pyridoxine 5'-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5'-phosphate into pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer. However, the role of PNPO and its regulatory mechanism in epithelial ovarian cancer (EOC) are unknown. In the present study, PNPO expression in human ovarian tumour tissue and its association with the clinicopathological features of patients with EOC were examined. Further, the biological function of PNPO in EOC cells and in xenograft was evaluated...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29238067/alternative-nhej-pathway-proteins-as-components-of-mycn-oncogenic-activity-in-human-neural-crest-stem-cell-differentiation-implications-for-neuroblastoma-initiation
#9
Erika A Newman, Sahiti Chukkapalli, Daniela Bashllari, Tina T Thomas, Raelene A Van Noord, Elizabeth R Lawlor, Mark J Hoenerhoff, Anthony W Opipari, Valerie P Opipari
Neuroblastoma is a cancer of neural crest stem cell (NCSC) lineage. Signaling pathways that regulate NCSC differentiation have been implicated in neuroblastoma tumorigenesis. This is exemplified by MYCN oncogene targets that balance proliferation, differentiation, and cell death similarly in normal NCSC and in high-risk neuroblastoma. Our previous work discovered a survival mechanism by which MYCN-amplified neuroblastoma circumvents cell death by upregulating components of the error-prone non-canonical alternative nonhomologous end-joining (alt-NHEJ) DNA repair pathway...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29238043/bcl-xl-overexpression-promotes-tumor-progression-associated-properties
#10
Daniela Trisciuoglio, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Chiara Gabellini, Simonetta Buglioni, Matteo Pallocca, Gabriele Alessandrini, Simona D'Aguanno, Donatella Del Bufalo
By using human melanoma and glioblastoma cell lines and their derivative BCL-XL overexpressing clones, we investigated the role of BCL-XL in aggressive features of these two tumor histotypes. We found that in both models, BCL-XL overexpression increased in vitro cell migration and invasion and facilitated tumor cells to form de novo vasculogenic structures. Furthermore, BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29237383/the-effect-of-flubendazole-on-adhesion-and-migration-in-sw480-and-sw620-colon-cancer-cells
#11
Veronika Hanusova, Lenka Skalova, Vera Kralova, Petra Matouskovs
Colon cancer is the most common type of gastrointestinal cancer. Despite advances during the last two decades, the efficacy of colorectal cancer treatment is still insufficient and new anticancer agents are necessary. In our study, colon cancer cells derived from a primary tumor (SW480) and lymph node metastasis (SW620) from the same patient were used and compared. The effect of FLU on cell adhesion and migration was monitored using the x-CELLigence Real-Time Cell Analysis system. Expressions of molecules involved in adhesion and migration were analyzed using RT-PCR and western blot...
December 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29237157/hypoxia-accelerates-aggressiveness-of-hepatocellular-carcinoma-cells-involving-oxidative-stress-epithelial-mesenchymal-transition-and-non-canonical-hedgehog-signaling
#12
Zhikui Liu, Kangsheng Tu, Yufeng Wang, Bowen Yao, Qing Li, Liang Wang, Changwei Dou, Qingguang Liu, Xin Zheng
BACKGROUND/AIMS: Hypoxic microenvironment, a common feature of hepatocellular carcinoma (HCC), can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) and invasion of cancer cells. However, the underlying molecular mechanisms have not fully elucidated. METHODS: HCC cells were cultured under controlled hypoxia conditions or normoxic conditions. Transwell assays were used to examine the migration and invasion capacity. HIF-1α siRNA, cyclopamine (a SMO antagonist) and GLI1 siRNA were used to inhibit HIF-1α transcription or Hh signaling activation...
December 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29236960/microrna-128-3p-mediated-depletion-of-drosha-promotes-lung-cancer-cell-migration
#13
Tania Frixa, Andrea Sacconi, Mario Cioce, Giuseppe Roscilli, Fabiana Fosca Ferrara, Luigi Aurisicchio, Claudio Pulito, Stefano Telera, Maria Antonia Carosi, Paola Muti, Sabrina Strano, Sara Donzelli, Giovanni Blandino
Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells...
December 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29236328/mirnalet-7a-mediates-prostate-cancer-pc-3-cell-invasion-migration-by-inducing-epithelial-mesenchymal-transition-through-ccr7-mapk-pathway
#14
Tang Guanlin, Du Ruoyang, Tang Zhaobing, Kuang Youlin
Prostate cancer is one of the most common malignancies in older men. Recent evidence has demonstrated microRNA (miRNA) Let-7a expression decreased in prostate cancer, while the expression of C-C chemokine receptor type 7 (CCR7) increased. In this study, we investigated whether CCR7 overexpression was associated with a decrease in the expression of miRNA let-7a in invasion and metastasis of prostate cancer cell. Methods Synthetic let-7a mimics and let-7a inhibitors were transfected into prostate cancer PC-3 cells repectively...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236327/pi3k-inhibitors-ic87114-inhibits-the-migration-and-invasion-of-thyroid-cancer-cell-in-vitro-and-in-vivo
#15
Yan Jiang, Shuai Hao, Wuguo Tian, Bo Gao, Xiaohua Zhang, Shu Zhang, Lingji Guo, Jie Yan, Donglin Luo
Thyroid cancer is currently the most common endocrine malignancies, and PI3K/Akt pathway play an important role during its initiation and development. IC87114 is an inhibitor of PI3K/Akt pathway. Little is known about the role of IC87114 in the initiation and progression of thyroid cancer. Here, we demonstrated that IC87114 significantly inhibited both the migration and invasion of thyroid cancer cells, which can be mediateded by inhibition of PI3K/Akt pathway.These results suggest that application of IC87114 may prove to be a particularly effective treatment for thyroid cancer...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236322/microrna-383-suppresses-the-pi3k-akt-mtor-signaling-pathway-to-inhibit-development-of-cervical-cancer-via-down-regulating-parp2
#16
Peng Teng, Yan Jiao, Min Hao, Xin Tang
This study aims to evaluate the effect of the regulatory relationship between microRNA-383 (miR-383) and PARP2 in the cell migration and invasion in human with cervical cancer (CC) via the PI3K-AKT-MTOR signaling pathway. Cancerous tissues and corresponding paracancerous tissues were collected from 115 patients with CC. The positive expression rate of PARP2 was detected by immunohistochemistry. Hela cells with highest miR-383 expression were selected and assigned into the blank, negative control (NC), miR-383 mimic, miR-383 inhibitor, si-PARP2 and miR-383 inhibitor + si-PARP2 groups...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236319/effects-of-long-non-coding-rna-host2-on-cell-migration-and-invasion-by-regulating-microrna-let-7b-in-breast-cancer
#17
Peng-Wei Lu, Lin Li, Fang Wang, Yuan-Ting Gu
The study intends to investigate the effects of long non-coding RNA HOST2 (lncRNA HOST2) on cell migration and invasion by regulating microRNA let-7b (let-7b) in breast cancer. Breast cancer and adjacent normal tissues were collected from 98 patients with breast cancer. Breast cancer MCF-7 cells were divided into the blank, negative control (NC), pcDNA3-Mock, siHOST2, let-7b inhibitor, pcDNA3-HOST2, let-7b mimic, pcDNA3-HOST2 + let-7b mimic and siHOST2 + let-7b inhibitor groups. RT-qPCR was used to detect the mRNA expressions of HOST2, let-7b and c-Myc...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236315/lnc-rna-snhg20-participated-in-proliferation-invasion-and-migration-of-breast-cancer-cells-via-mir-495
#18
Yan-Xing Guan, Zhan-Min Zhang, Xue-Zhong Chen, Qing Zhang, Shao-Zheng Liu, Yong-Lu Zhang
OBJECTIVE: To explore the mechanism of lnc SNHG20 in the regulation of proliferation, invasion and migration of breast cancer cells. MATERIALS AND METHODS: mRNA levels of SNHG20, miR-495 and HER2 were detected by qRT-PCR. Protein level of HER2 was measured by Western blot. Cell proliferation, invasion and migration were detected by CCK-8 assay, Boyden chamber assay and Transwell assay. The combination between SNHG20 and miR-495 was confirmed by RNA pull down assay...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236310/insulin-induces-an-emt-like-process-in-mammary-epithelial-cells-mcf10a
#19
Cecilia Rodriguez-Monterrosas, Ricardo Díaz-Aragon, Elizabeth Leal-Orta, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Diabetes mellitus has been related with an increased risk of breast cancer, whereas it has been suggested that links between diabetes mellitus and cancer are hyperinsulinemia, insulin resistance, hyperglycemia and chronic inflammation induced by adipose tissue. Contribution of hyperinsulinemia to carcinogenesis is mediated through resistance to endogenous insulin and by exogenous insulin used in treatment. Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells are transdifferentiated to a mesenchymal state that has been implicated in cancer progression...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236308/database-of-transcription-factors-in-lung-cancer-dbtflc-a-novel-resource-for-exploring-transcription-factors-associated-with-lung-cancer
#20
A Thabitha, Ameya Athul Dravid, Riya Tripathi, S Sajitha Lulu
Lung cancer is considered as the most prevalent form of cancer and it is found to be frequent cause of cancer related death. Even though, approved molecular targeted therapies other than chemotherapy are currently unavailable, the mechanism of pathogenesis in lung cancer remains still unclear. Transcription factors (TFs) play a critical role in cancer cell processes, such as cell proliferation, apoptosis, migration, and regulate gene expression. Thus, the identification and characterization of transcription factors involved in lung cancer would provide valuable information for further elucidation of the mechanism(s) underlying pathogenesis and the identification of potential therapeutic target types, which are critical for the development of therapeutic strategies...
December 13, 2017: Journal of Cellular Biochemistry
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