Lydia Rebehn, Samira Khalaji, Fenneke KleinJan, Anja Kleemann, Fabian Port, Patrick Paul, Constantin Huster, Ulla Nolte, Karmveer Singh, Lisa Kwapich, Jonas Pfeil, Taner Pula, Pamela Fischer-Posovszky, Karin Scharffetter-Kochanek, Kay-E Gottschalk
Skin is the largest human organ with easily noticeable biophysical manifestations of aging. As human tissues age, there is chronological accumulation of biophysical changes due to internal and environmental factors. Skin aging leads to decreased elasticity and the loss of dermal matrix integrity via degradation. The mechanical properties of the dermal matrix are maintained by fibroblasts, which undergo replicative aging and may reach senescence. While the secretory phenotype of senescent fibroblasts is well studied, little is known about changes in the fibroblasts biophysical phenotype...
August 22, 2023: Proceedings of the National Academy of Sciences of the United States of America