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https://www.readbyqxmd.com/read/29776156/realizations-of-highly-heterogeneous-collagen-networks-via-stochastic-reconstruction-for-micromechanical-analysis-of-tumor-cell-invasion
#1
Hanqing Nan, Long Liang, Guo Chen, Liyu Liu, Ruchuan Liu, Yang Jiao
Three-dimensional (3D) collective cell migration in a collagen-based extracellular matrix (ECM) is among one of the most significant topics in developmental biology, cancer progression, tissue regeneration, and immune response. Recent studies have suggested that collagen-fiber mediated force transmission in cellularized ECM plays an important role in stress homeostasis and regulation of collective cellular behaviors. Motivated by the recent in vitro observation that oriented collagen can significantly enhance the penetration of migrating breast cancer cells into dense Matrigel which mimics the intravasation process in vivo [Han et al...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29774668/varicocele-and-testicular-pain-a-review
#2
REVIEW
Sunghyun Paick, Woo Suk Choi
Varicocele is the dilatation of the scrotal portion of pampiniform plexus and the internal spermatic venous system. About 15% of men suffer from scrotal varicocele and 2% to 10% of them complain of pain. The probable mechanisms for pain include compression of the surrounding neural fibers by the dilated venous complex, elevated testicular temperature, increased venous pressure, hypoxia, oxidative stress, hormonal imbalances, and the reflux of toxic metabolites of adrenal or renal origin. Testicular pain associated with varicoceles is typically described as a dull, aching, or throbbing pain in the testicle, scrotum, or groin; rarely, it can be acute, sharp, or stabbing...
May 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29774637/potassium-octatitanate-fibers-induce-persistent-lung-and-pleural-injury-and-are-possibly-carcinogenic-in-male-fischer-344-rats
#3
Mohamed Abdelgied, Ahmed M El-Gazzar, David B Alexander, William T Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hirotsugu Takase, Khaled Abbas Abdou, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Hiroyuki Tsuda, Satoru Takahashi
Potassium octatitanate fibers (K2 O•8TiO2 , POT fibers) are widely used as an alternative to asbestos. We investigated the pulmonary and pleural toxicity of POT fibers with reference to 2 non-fibrous titanium dioxide nanoparticles (nTiO2 ), photo-reactive anatase (a-nTiO2 ) and inert rutile (r-nTiO2 ). Ten-week old male F344 rats were administered 0.5 ml of 250-μg/ml suspensions of POT fibers, a-nTiO2 , or r-nTiO2 , eight times (1 mg/rat) over a 15 day period by trans-tracheal intrapulmonary spraying (TIPS)...
May 17, 2018: Cancer Science
https://www.readbyqxmd.com/read/29772384/facile-preparation-of-biocompatible-poly-lactic-acid-reinforced-poly-%C3%AE%C2%B5-caprolactone-fibers-via-graphite-nanoplatelets-aided-melt-spinning
#4
Ivan Kelnar, Alexander Zhigunov, Ludmila Kaprálková, Ivan Fortelný, Jiří Dybal, Jaroslav Kratochvíl, Martina Nevoralová, Marcela Hricová, Viera Khunová
Addition of high-aspect-ratio (AR) nanofillers can markedly influence flow behavior of polymer systems. As a result, application of graphite nanoplatelets (GNP) allows preparation of microfibrillar composites (MFC) based on PCL matrix reinforced with in-situ generated PLA fibrils. This work deals, for the first time, with preparation of analogous melt-drawn fibers. Unlike other blend-based fibers, the spinning and melt drawing leads to structure of deformed inclusions due to unfavorable ratio of rheological parameters of components...
May 9, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29768506/genome-wide-classification-evolutionary-analysis-and-gene-expression-patterns-of-the-kinome-in-gossypium
#5
Jun Yan, Guilin Li, Xingqi Guo, Yang Li, Xuecheng Cao
The protein kinase (PK, kinome) family is one of the largest families in plants and regulates almost all aspects of plant processes, including plant development and stress responses. Despite their important functions, comprehensive functional classification, evolutionary analysis and expression patterns of the cotton PK gene family has yet to be performed on PK genes. In this study, we identified the cotton kinomes in the Gossypium raimondii, Gossypium arboretum, Gossypium hirsutum and Gossypium barbadense genomes and classified them into 7 groups and 122-24 subfamilies using software HMMER v3...
2018: PloS One
https://www.readbyqxmd.com/read/29768017/the-signaling-network-resulting-in-ventilator-induced-diaphragm-dysfunction
#6
Huibin Tang, Joseph B Shrager
Mechanical ventilation (MV) is a life-saving measure for those incapable of adequately ventilating or oxygenating without assistance. Unfortunately, even brief periods of MV result in diaphragm weakness (i.e., "ventilator-induced diaphragm dysfunction" - VIDD) that may render it difficult to wean the ventilator. Prolonged MV is associated with cascading complications and is a strong risk factor for death. Thus, prevention of VIDD may have a dramatic impact on mortality rates. Here, we summarized the current understanding of the pathogenic events underlying VIDD...
May 16, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29764991/a-dgk%C3%AE-foxo-ubiquitin-proteolytic-axis-controls-fiber-size-during-skeletal-muscle-remodeling
#7
Jae-Sung You, Matthew S Dooley, Chan-Ran Kim, Eui-Jun Kim, Wei Xu, Craig A Goodman, Troy A Hornberger
Skeletal muscle rapidly remodels in response to various stresses, and the resulting changes in muscle mass profoundly influence our health and quality of life. We identified a diacylglycerol kinase ζ (DGKζ)-mediated pathway that regulated muscle mass during remodeling. During mechanical overload, DGKζ abundance was increased and required for effective hypertrophy. DGKζ not only augmented anabolic responses but also suppressed ubiquitin-proteasome system (UPS)-dependent proteolysis. We found that DGKζ inhibited the transcription factor FoxO that promotes the induction of the UPS...
May 15, 2018: Science Signaling
https://www.readbyqxmd.com/read/29763575/social-isolation-reduces-serotonergic-fiber-density-in-the-inferior-colliculus-of-female-but-not-male-mice
#8
Sarah M Keesom, Mitchell D Morningstar, Rebecca Sandlain, Bradley M Wise, Laura M Hurley
Early-life experiences, including maternal deprivation and social isolation during adolescence, have a profound influence on a range of adult social behaviors. Post-weaning social isolation in rodents influences behavior in part through the alteration of neuromodulatory systems, including the serotonergic system. Of significance to social behavior, the serotonergic system richly innervates brain areas involved in vocal communication, including the auditory system. However, the influence of isolation on serotonergic input to the auditory system remains underexplored...
May 12, 2018: Brain Research
https://www.readbyqxmd.com/read/29763548/zein-increases-the-cytoaffinity-and-biodegradability-of-scaffolds-3d-printed-with-zein-and-poly-%C3%AE%C2%B5-caprolactone-composite-ink
#9
Linzhi Jing, Xiang Wang, Hang Liu, Yuyun Lu, Jinsong Bian, Jie Sun, Dejian Huang
Electrohydrodynamic printing (EHDP) has attracted extensive interests as a powerful technology to fabricate micro to nanoscale fibrous scaffolds in a custom-tailored manner for biomedical applications. A few synthetic biopolymer inks are applicable to this EHDP technology, but the fabricated scaffolds suffered from low mechanical strength, biocompatibility and biodegradability. In this study, a series of poly(ε-caprolactone)(PCL)/zein composite inks were developed and their printability was examined on a solution-based EHDP system for scaffold fabrication...
May 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29760296/hydroxytyrosol-and-olive-leaf-extract-exert-cardioprotective-effects-by-inhibiting-grp78-and-chop-expression
#10
Lixing Wu, Yuyu Xu, Zhijian Yang, Qing Feng
Myocardial infarction triggers massive biochemical changes, even cardiac cell death. Endoplasmic reticulum stress is involved in the pathology of myocardial infarction-mediated apoptosis. In the present study, myocardial cell line H9c2 cells were treated with cobalt chloride (CoCl2 ) to induce hypoxia. Isoproterenol was used for two successive days to induce myocardial infarction in SD rats. The cardioprotective effect of olive leaf extract (OLE) and its main constituent hydroxytyrosol and the underlying mechanisms were evaluated...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29760064/helical-rotation-of-the-diaphanous-related-formin-mdia1-generates-actin-filaments-resistant-to-cofilin
#11
Hiroaki Mizuno, Kotaro Tanaka, Sawako Yamashiro, Akihiro Narita, Naoki Watanabe
The complex interplay between actin regulatory proteins facilitates the formation of diverse cellular actin structures. Formin homology proteins (formins) play an essential role in the formation of actin stress fibers and yeast actin cables, to which the major actin depolymerizing factor cofilin barely associates. In vitro, F-actin decorated with cofilin exhibits a marked increase in the filament twist. On the other hand, a mammalian formin mDia1 rotates along the long-pitch actin helix during processive actin elongation (helical rotation)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29758001/an-antimicrobial-peptide-loaded-gelatin-chitosan-nanofibrous-membrane-fabricated-by-sequential-layer-by-layer-electrospinning-and-electrospraying-techniques
#12
Yuzhu He, Yahui Jin, Xiumei Wang, Shenglian Yao, Yuanyuan Li, Qiong Wu, Guowu Ma, Fuzhai Cui, Huiying Liu
Guided bone regeneration (GBR) technique is widely used in the treatment of bone defects caused by peri-implantitis, periodontal disease, etc. However, the GBR membranes commonly used in clinical treatments currently have no antibacterial activity. Therefore, in this study, sequential layer-by-layer electrospinning and electrospraying techniques were utilized to prepare a gelatin (Gln) and chitosan (CS) composite GBR membrane containing hydroxyapatite nanoparticles (nHAp) and antimicrobial peptide (Pac-525)-loaded PLGA microspheres (AMP@PLGA-MS), which was supposed to have osteogenic and antibacterial activities...
May 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29756670/the-influence-of-post-system-design-and-material-on-the-biomechanical-behavior-of-teeth-with-little-remaining-coronal-structure
#13
Cristiano Lazzari Pinto, Claudia Lopes Brilhante Bhering, Gabriel Rodrigues de Oliveira, Angélica Maroli, Vagner Flávio Reginato, Ricardo Armini Caldas, Atais Bacchi
PURPOSE: To evaluate the influence of different post systems on the biomechanical behavior of teeth with a severe loss of remaining coronal structure. MATERIALS AND METHODS: Fifty standardized bovine teeth (n = 10 per group) were restored with: cast post-and-core (CPC), prefabricated metallic post (PFM), parallel glass-fiber post (P-FP), conical glass-fiber post (C-FP), or composite core (no post, CC). The survival rate during thermomechanical challenging (TC), the fracture strength (FS), and failure patterns (FP) were evaluated...
May 14, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29752407/integrin-%C3%AE-v%C3%AE-3-associated-daam1-is-essential-for-collagen-induced-invadopodia-extension-and-cell-haptotaxis-in-breast-cancer-cells
#14
Ting Yan, Ailiang Zhang, Fangfang Shi, Fei Chang, Jie Mei, Yongjian Liu, Yichao Zhu
The formin protein dishevelled-associated activator of morphogenesis 1 (DAAM1) polymerizes straight actin filaments and mediates migration of cancer cells. However, how DAAM1 governs cell haptotaxis in response to collagen remains unexplored in breast cancer cells. We hypothesized that DAAM1 mediates invadopodia extension and cell haptotaxis in response to type IV collagen in association with integrin receptors. Using Boyden chamber membranes coated with type IV collagen, we show here that type IV collagen activates both DAAM1 and  Ras homolog family member A (RHOA)  and promotes haptotaxis of MDA-MB-231 and MDA-MB-453 breast cancer cells, a process abolished by treatment with the integrin αvβ3 inhibitor cyclo(-RGDfK)...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29751634/rho-a-regulates-epidermal-growth-factor-induced-human-osteosarcoma-mg63-cell-migration
#15
Jinyang Wang, Lei Zhang, Rongmei Qu, Lin Zhang, Wenhua Huang
Osteosarcoma, the most common primary bone tumor, occurs most frequently in children and adolescents and has a 5-year survival rate, which is unsatisfactory. As epidermal growth factor receptor (EGFR) positively correlates with TNM (tumor-node-metastasis) stage in osteosarcoma, EGFR may play an important role in its progression. The purpose of this study was to explore potential mechanisms underlying this correlation. We found that EGF promotes MG63 cell migration and invasion as well as stress fiber formation via Rho A activation and that these effects can be reversed by inhibiting Rho A expression...
May 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750899/bmp-2-enhances-the-migration-and-proliferation-of-hypoxia-induced-vsmcs-via-actin-cytoskeleton-cd44-and-matrix-metalloproteinase-linkage
#16
Min Yang, Zhiqin Fan, Fei Wang, Zhi-Hua Tian, Bo Ma, Bing Dong, Zhongwu Li, Ming Zhang, Wei Zhao
The persistent proliferation of hypoxia-induced vascular smooth muscle cells (VSMCs) in the arterial wall underlie the development of atherosclerosis. However, the mechanism that regulates the behavior of VSMCs, which involve in actin aggregation, and impedes their migration is still elusive. Here, we report that bone morphogenetic protein 2 (BMP-2) leads to enrichment of CD44 and F-actin stress fiber and secretion of matrix metalloproteinases-2 (MMP-2) during hypoxia in vitro and following artificial hypoxia-induced atherosclerosis exacerbation in vivo...
May 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29748722/polymorphic-transformation-of-indomethacin-during-hot-melt-extrusion-granulation-process-and-dissolution-control
#17
Ting Xu, Kajalajit Nahar, Rutesh Dave, Simon Bates, Kenneth Morris
PURPOSE: To study and elucidate the effect of the intensity and duration of processing stresses on the possible solid-state changes during a hot melt extrusion granulation process. METHODS: Blends of α-indomethacin and PEG 3350 (w/w 4:1) were granulated using various screw sizes/designs on the melt extruder under different temperature regimes. Differential Scanning Calorimetry and X-ray Powder Diffraction were employed for characterization. The dissolution behavior of the pure polymorphs and the resulting granules was determined using in-situ fiber optic UV testing system...
May 10, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29747911/evaluation-of-early-resin-luting-cement-damage-induced-by-voids-around-a-circular-fiber-post-in-a-root-canal-treated-premolar-by-integrating-micro-ct-finite-element-analysis-and-fatigue-testing
#18
Yen-Hsiang Chang, Hsuan-Wen Wang, Pei-Hsun Lin, Chun-Li Lin
OBJECTIVE: This study utilizes micro-CT image combined with finite element (FE) analysis and in vitro fatigue testing to investigate the mechanical behavior associating with early resin luting cement damage induced by voids around a circular fiber post in a root canal treated premolar. METHODS: Six similar mandibular first premolars with root canal treatment were scanned with high resolution micro-CT before and after fatigue testing. Micro-CT images of all teeth were processed to identify various materials (dentin, luting cement and void) to evaluate the volume/position of the void in each reconstructed tooth root canal model...
May 7, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29746415/histology-of-geographic-atrophy-secondary-to-age-related-macular-degeneration-a-multilayer-approach
#19
Miaoling Li, Carrie Huisingh, Jeffrey Messinger, Rosa Dolz-Marco, Daniela Ferrara, K Bailey Freund, Christine A Curcio
PURPOSE: To systematically characterize histologic features of multiple chorioretinal layers in eyes with geographic atrophy, or complete retinal pigment epithelium (RPE) and outer retinal atrophy, secondary to age-related macular degeneration, including Henle fiber layer and outer nuclear layer; and to compare these changes to those in the underlying RPE-Bruch membrane-choriocapillaris complex and associated extracellular deposits. METHODS: Geographic atrophy was delimited by the external limiting membrane (ELM) descent towards Bruch membrane...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29745937/tgf-%C3%AE-induces-changes-in-breast-cancer-cell-deformability
#20
Ankur Kulkarni, Aritra Chatterjee, Paturu Kondaiah, Namrata Gundiah
Mechanical properties of cells regulate cell behaviors which lead to phenotypic changes that may aid in the development and progression of disease. In this study, we used atomic force microscopy (AFM) indentation with a spherical probe to characterize the elastic and viscoelastic properties of invasive (MDA-MB-231) and noninvasive (MCF-7) breast cancer cells treated with transforming growth factor-β (TGF-β). We also used confocal fluorescence imaging to investigate the sub-membrane cytoskeletal structure of the cells...
May 10, 2018: Physical Biology
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