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Cervical cancer prevention

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https://www.readbyqxmd.com/read/29442477/role-of-thyroid-ultrasound-combined-with-thyroglobulin-in-the-diagnosis-of-postoperative-recurrence-of-thyroid-cancer
#1
Li Zhang, Guilan Zou
BACKGROUND: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice. METHODS: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29442400/what-information-can-change-the-attitude-of-teachers-toward-the-human-papillomavirus-vaccine
#2
Masaharu Kamada, Hiroaki Inui, Tomohiro Kagawa, Ayuka Mineda, Takao Tamura, Tomohito Fujioka, Takahiro Motoki, Hiroki Hirai, Eiichi Ishii, Minoru Irahara
AIM: We conducted a self-administered survey on the perception of teachers toward human papillomavirus (HPV) vaccine to determine the ways to increase their willingness to encourage its use. METHODS: Answers were obtained both prior to and after having the teachers read five brief information articles: (i) cervical cancer knowledge, (ii) vaccine knowledge, (iii) result of a survey in Nagoya, (iv) news report of the World Health Organization statement and (v) articles written by Dr Muranaka, a journalist...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29441934/implants-composed-of-digoxin-and-poly-%C3%AE%C2%B5-caprolactone-development-characterization-anti-proliferative-and-anti-angiogenic-activities
#3
F F Rodrigues, W R Braz, F B Perasoli, L G R Ferreira, L A de O Barbosa, G R Da Silva
Drug delivery systems could be applied to locally treat cervical cancer, thus preventing the drawbacks of conventional therapy. In this study, anti-proliferative and anti-angiogenic effects of digoxin incorporated into poly(ε-caprolactone) implants were evaluated, aiming at the local treatment of cervical cancer. Implants were characterized, and the in vitro release profile of digoxin was demonstrated. Anti-proliferative and anti-angiogenic activities of digoxin were investigated by using chorioallantoic membrane and human cervix carcinoma (HeLa) cells, respectively...
July 3, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441700/knowledge-about-cervical-cancer-and-barriers-toward-cervical-cancer-screening-among-hiv-positive-women-attending-public-health-centers-in-addis-ababa-city-ethiopia
#4
Saba Shiferaw, Adamu Addissie, Muluken Gizaw, Selamawit Hirpa, Wondimu Ayele, Sefonias Getachewe, Eva J Kantelhardt, Mathewos Assefa, Ahmedin Jemal
Screening rate for cervical cancer among HIV-infected women and among women overall is low in Ethiopia despite the high burden of the disease and HIV infection, which increases cervical cancer risk. In this paper, we assessed knowledge about cervical cancer symptoms, prevention, early detection, and treatment and barriers to screening among HIV-positive women attending community health centers for HIV-infection management in Addis Ababa. A cross-sectional survey of 581 HIV-positive women aged 21-64 years old attending 14 randomly selected community health centers without cervical cancer screening service in Addis Ababa...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29435291/efficacy-and-safety-of-doceaqualip-in-a-patient-with-locally-advanced-cervical-cancer-a-case-report
#5
Rammohan Prasanna, Deepak Bunger, Mujtaba A Khan
The standard of care for locally advanced cervical cancer has been the combination of a taxane with platinum based therapy. Conventional docetaxel is known to cause hypersensitivity reactions, fluid retention and other toxicities due to polysorbate-80 and ethanol. Corticosteroid premedication prior to docetaxel administration is required to prevent these toxicities, however, toxicities are still observed, sometimes fatal, despite premedication. DoceAqualip, a nanosomal docetaxel lipid suspension, developed with lipids generally regarded as safe (GRAS) by the US Food and Drug Administration, is devoid of polysorbate-80 and ethanol...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29434897/folate-deficiency-and-aberrant-dna-methylation-and-expression-of-fhit-gene-were-associated-with-cervical-pathogenesis
#6
Qiaoling Li, Ling Ding, Nan Jing, Chunliang Liu, Zuokai Yang, Fang Chen, Lifang Hou, Jintao Wang
Aberrant DNA methylation is a recognized feature in various types of human cancer, and folate has a vital role in the epigenetics of mammalian cells by supplying methyl groups for DNA methylation reactions. Fragile histidine triad (FHIT) is a tumor suppressor gene that is frequently silenced in cervical cancer (CC) and preneoplastic lesions. Promoter hypermethylation was previously observed in CC, and its epigenetic silencing has been observed at mRNA or protein levels. Changes in folate intake to modulate DNA methylation may be a mechanistic link to cancer, but this remains to be elucidated...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434755/anti-tumour-effects-of-polysaccharide-extracted-from-acanthopanax-senticosus-and-cell-mediated-immunity
#7
Qinglong Meng, Jingzhi Pan, Yajing Liu, Li Chen, Yueying Ren
Acanthopanax senticosus, also known as Siberian ginseng, is widely distributed throughout northern Asia and used in traditional Chinese medicine; it has been reported to prevent a number of diseases. However, the association between the antitumour and immunostimulatory activities of polysaccharide extracted from A. senticosus (ASPS) remains to be elucidated. The aim of the present study was to investigate the anti-tumour and immunomodulatory effects of polysaccharide extracted from ASPS on Crocker sarcoma S180, hepatic carcinoma H22 and uterine cervical carcinoma U14 tumour cell lines implanted in mice...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432665/ptld-prevention-new-light-on-the-horizon
#8
Thomas Fehr
Solid organ transplantation represents the ultimate therapeutic option for terminal organ failure and has experienced a tremendous success in the last decades. However, major problems, such as the risks associated with life-long immunosuppression, have not been resolved so far. These risks are mainly three-fold: (i) infections (usual and opportunistic ones), (ii) increased cancer incidence, and (iii) cardiovascular complications (newly induced or aggravated by chronic immunosuppression) (1). There is also a close relation between infection and cancer, since certain viruses directly cause cancers such as post-transplant lymphoproliferative disorder (PTLD; mainly caused by Epstein-Barr virus, EBV), cervical cancer (papillomavirus) or Kaposi sarcoma (human herpesvirus 8) (2)...
February 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29431861/non-steroidal-anti-inflammatory-agents-to-induce-regression-and-prevent-the-progression-of-cervical-intraepithelial-neoplasia
#9
REVIEW
Shannon M Grabosch, Osman M Shariff, C William Helm
BACKGROUND: This is an updated version of the original Cochrane review published in 2014, Issue 4. Cervical intraepithelial neoplasia (CIN) precedes the development of invasive carcinoma of the cervix. Current treatment of CIN is quite effective, but there is morbidity for the patient related to pain, bleeding, infection, cervical stenosis and premature birth in a subsequent pregnancy. Effective treatment with medications, rather than surgery, would be beneficial. OBJECTIVES: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of CIN...
February 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29428270/-ten-years-of-human-papilloma-virus-vaccination-from-dermatology-to-oncology-via-the-infectious-diseases-department
#10
Fernando A Moraga-Llop
Human papilloma virus (HPV) was first identified in dermatology, and it was subsequently demonstrated that is was required for the development of uterine cervical cancer and other tumours, after a persistent infection by any of its oncogenic genotypes. Ten years ago, the most common infections and cancers associated with HPV could be prevented by immunisation with 2vaccines, one bivalent, and another tetravalent, and having just marketed a nonavalent one. During the period 2007-2008, the HPV vaccine was included in the Autonomous Communities vaccination calendar, and it is the second vaccine, after that of Hepatitis B, that prevents cancer...
February 7, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29426344/implementation-strategies-to-improve-cervical-cancer-prevention-in-sub-saharan-africa-a-systematic-review
#11
REVIEW
Lauren G Johnson, Allison Armstrong, Caroline M Joyce, Anne M Teitelman, Alison M Buttenheim
BACKGROUND: Developed countries, such as the USA, have achieved significant decreases in cervical cancer burden since the introduction of Pap smear-based programs in the 1960s. Due to implementation barriers and limited resources, many countries in sub-Saharan Africa (SSA) have been unable to attain such reductions. The purpose of this review is to evaluate implementation strategies used to improve the uptake and sustainability of cervical cancer prevention programs in SSA. METHODS: A reviewer (LJ) independently searched PubMed, Ovid/MEDLINE, Scopus, and Web of Science databases for relevant articles with the following search limits: English language, peer reviewed, and published between 1996 and 2017...
February 9, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29425225/an-integrated-strategy-for-improving-contrast-durability-and-portability-of-a-pocket-colposcope-for-cervical-cancer-screening-and-diagnosis
#12
Christopher T Lam, Jenna Mueller, Betsy Asma, Mercy Asiedu, Marlee S Krieger, Rhea Chitalia, Denali Dahl, Peyton Taylor, John W Schmitt, Nimmi Ramanujam
INTRODUCTION: We have previously developed a portable Pocket Colposcope for cervical cancer screening in resource-limited settings. In this manuscript we report two different strategies (cross-polarization and an integrated reflector) to improve image contrast levels achieved with the Pocket Colposcope and evaluate the merits of each strategy compared to a standard-of-care digital colposcope. The desired outcomes included reduced specular reflection (glare), increased illumination beam pattern uniformity, and reduced electrical power budget...
2018: PloS One
https://www.readbyqxmd.com/read/29424661/preventive-care-among-primary-care-patients-living-with-spinal-cord-injury
#13
Aisha Lofters, Maha Chaudhry, Morgan Slater, Andree Schuler, James Milligan, Joseph Lee, Sara J T Guilcher
OBJECTIVE: Context/Objective: Family physicians may lack the knowledge or resources to adequately support patients with spinal cord injury (SCI). Our objectives were to determine patterns of preventive care for patients with SCI in a primary care setting (i.e. cancer screening, influenza vaccinations, general physicals, bone mineral density tests), and determine physicians' level of comfort with providing primary care to patients with SCI. DESIGN: i) Retrospective chart review, ii) Survey of physicians in the family practice...
February 9, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29416557/prevalence-of-human-papillomavirus-infection-among-iranian-women-using-cobas-hpv-dna-testing
#14
Farzane Jamdar, Farah Farzaneh, Fariba Navidpour, Sarang Younesi, Payam Balvayeh, Maryamsadat Hosseini, Robabeh Ghodssi-Ghasemabadi
Background: Persistent infection with High Risk Human Papillomavirus (HR HPV) typesplaysamajor role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cancer screening. The aim of this study was to estimate the prevalence of HR HPV infection among healthy women undergoing routine cervical cancer screening in Iran. Methods: In this cross-sectional study,the results of HPV DNA typing in 2453 normal Iranian womenwhowere referred for routine cervical cancer screening from September 2015 to March 2017 were analyzed...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29413464/harnessing-genomics-to-improve-outcomes-for-women-with-cancer-in-india-key-priorities-for-research
#15
REVIEW
Sudha Sundar, Poonam Khetrapal-Singh, Jon Frampton, Edward Trimble, Preetha Rajaraman, Ravi Mehrotra, Roopa Hariprasad, Arindam Maitra, Paramjit Gill, Vanita Suri, Radhika Srinivasan, Gurpreet Singh, J S Thakur, Preet Dhillon, Jean-Baptiste Cazier
Cumulatively, breast, cervical, ovarian, and uterine cancer account for more than 70% of cancers in women in India. Distinct differences in the clinical presentation of women with cancer suggest underlying differences in cancer biology and genetics. The peak age of onset of breast and ovarian cancer appears to be a decade earlier in India (age 45-50 years) than in high-income countries (age >60 years). Understanding these differences through research to develop diagnosis, screening, prevention, and treatment frameworks that ar e specific to the Indian population are critical and essential to improving women's health in India...
February 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29412063/a-mixed-methods-review-of-education-and-patient-navigation-interventions-to-increase-breast-and-cervical-cancer-screening-for-rural-women
#16
Derek Falk
Reviews have assessed studies of breast and cervical cancer screening access and utilization for rural women, but none analyze interventions to increase screening rates. A mixed methods literature search identified studies of breast and/or cervical cancer prevention education and patient navigation interventions for rural women. Rural areas need greater implementation and evaluation of screening interventions as these services address the challenges of delivering patient-centered cancer care to un-/underserved communities...
February 7, 2018: Social Work in Public Health
https://www.readbyqxmd.com/read/29408192/sociodemographic-and-lifestyle-determinants-of-non-attendance-for-cervical-cancer-screening-in-lithuania-2006-2014
#17
J Petkeviciene, R Ivanauskiene, J Klumbiene
OBJECTIVES: In 2004, Lithuania started the Nationwide Cervical Cancer Screening Programme. The aim of the study was to estimate the trend in the uptake of cervical cancer (CC) screening in Lithuania during 2006-2014 and to identify sociodemographic and lifestyle factors associated with non-attendance for screening. STUDY DESIGN: Cross-sectional studies. METHODS: The data of 4248 women aged 25-60 years who participated in population-based cross-sectional surveys of Lithuanian Health Behaviour Monitoring were analysed...
January 29, 2018: Public Health
https://www.readbyqxmd.com/read/29395515/barriers-to-immunization-among-newcomers-a-systematic-review
#18
Lindsay Wilson, Taylor Rubens-Augustson, Malia Murphy, Cindy Jardine, Natasha Crowcroft, Charles Hui, Kumanan Wilson
INTRODUCTION: Currently, there is a lack of comprehensive evidence exploring vaccine decision-making among newcomers. We conducted a systematic review of qualitative studies aimed at identifying factors that influence newcomers' decision-making with regards to vaccination. METHODS: We conducted a search of MEDLINE, EMBASE, CINAHL and Cochrane Central. To be included, studies needed to employ a qualitative methodology and address newcomer attitudes, beliefs, and/or perceptions regarding vaccination...
January 21, 2018: Vaccine
https://www.readbyqxmd.com/read/29395307/tumor-associated-macrophages-in-gynecologic-cancers
#19
REVIEW
Venkatesh Krishnan, Bruce Schaar, Supreeti Tallapragada, Oliver Dorigo
The complex tumor microenvironment in gynecologic cancers plays a major role in modulating anti-tumor immune responses. The interaction of cancer cells with the diverse spectrum of immune effector cells has an important impact on the efficacy of standard chemotherapy and novel immunotherapy approaches. In this review, we specifically focus on the role of macrophages in ovarian, endometrial and cervical cancers. We discuss the origins of macrophages and their polarization state dictated by the microenvironment's cues...
January 22, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29394795/-a-case-report-on-successful-larynx-preserving-surgery-for-a-cervical-esophageal-cancer-that-invaded-the-hypopharynx
#20
Osamu Shiraishi, Hiroaki Kato, Mitsuru Iwama, Yoko Hiraki, Atsushi Yasuda, Masayuki Shinkai, Motohiro Imano, Yutaka Kimura, Haruhiko Imamoto, Takushi Yasuda
The patient was a 58-year-old man suffering from dysphagia. He was diagnosed with T3 cervicalesophagealcancer that invaded the posterior hypopharyngealwal lwith lymph node metastasis. The patient received neoadjuvant chemoradiotherapy (30 Gy with CDDP/5-FU), followed by larynx-preserving surgery(LPS)for cervicalesophagealcancer. Two techniques for successfulLPS consist of the dissections of cricopharyngealmuscl e and the inferior pharyngealsphincter, and the complete division of the bilateral infrahyoid muscles attached to the sternum(CDBIMS)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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