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https://www.readbyqxmd.com/read/29224043/identification-of-human-papillomavirus-hpv-subtype-in-oral-cancer-patients-through-microarray-technology
#1
Soung Min Kim, Ik Jae Kwon, Hoon Myoung, Jong Ho Lee, Suk Keun Lee
PURPOSE: Human papilloma virus (HPV) is the main source of cervical cancer. Many recent studies have revealed the prevalence and prognosis of HPV associated with oropharyngeal squamous cell carcinoma, but fewer reports have evaluated HPV in oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the prevalence and prognosis of HPV associated with OSCC according to HPV and tumor types. MATERIALS AND METHODS: We used a DNA chip kit (MY-HPV chip kit ®, Mygene Co...
December 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29223946/-quality-of-the-exo-endocervical-sampling-in-the-prevention-of-uterine-cervix-cancer
#2
Anabela A Angeleri, Lili B Díaz, Gisela Coliva, Fernando Guerra, Luis A Palaoro, Adriana E Rocher
Cervical and vaginal cytology, Papanicolaou test (PAP), is the most effective test for screening of preneoplastic lesions, and cervical cancer prevention. Its sensitivity goes from 50 to 98%, according to different statistics, and this variation is related to the sampling procedure. A satisfactory smear should be taken from the transformation zone, the junction between endocervix and exocervix. According to Bethesda, metaplastic and/or endocervical cells should be observed under the microscope. The traditional PAP smear includes an exo-endocervical sampling using the Ayre spatula; however, only near 50% of the smears are representative of the transformation zone...
2017: Medicina
https://www.readbyqxmd.com/read/29222509/impact-of-model-calibration-on-cost-effectiveness-analysis-of-cervical-cancer-prevention
#3
David Moriña, Silvia de Sanjosé, Mireia Diaz
Markov chain models are commonly used to simulate the natural history of human papillomavirus infection and subsequent cervical lesions with the aim of predicting future benefits of health interventions. Developing and calibrating these models entails making a number of critical decisions that will influence the ability of the model to reflect real conditions and predict future situations. Accuracy of selected inputs and calibration procedures are two of the crucial aspects for model performance and understanding their influence is essential, especially when involves policy decisions...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29210616/mothers-willingness-to-pay-for-daughters-hpv-vaccine-in-northern-vietnam
#4
Ha Dinh Thu, Huong Nguyen Thanh, Thuy Hua Thanh, Le Nguyen Hai, Van Tran Thi, Nguyen Manh Tri, Anne Buvé
HPV vaccine is effective in preventing Human papillomavirus, the main cause of cervical cancer. In Vietnam, at first, it was subsidized at $5░a dose and reached the coverage of 96% in 2 pilot provinces, indicating potentially high acceptance. Currently, it is provided at $120-195 for three doses. This is a cross-sectional study, conducted in two northern rural districts of Vietnam. Researchers present findings to show 53.1% of mothers stated their willingness to pay (WTP) for HPV vaccine for their daughters...
December 6, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/29207966/study-protocol-for-a-cluster-randomized-trial-to-compare-human-papillomavirus-based-cervical-cancer-screening-in-community-health-campaigns-versus-health-facilities-in-western-kenya
#5
Megan J Huchko, James G Kahn, Jennifer S Smith, Robert A Hiatt, Craig R Cohen, Elizabeth Bukusi
BACKGROUND: Despite guidelines for cervical cancer prevention in low-resource countries, a very small proportion of women in these settings undergo screening, and even fewer women are successfully treated. Using pilot data from western Kenya and World Health Organization recommendations, we developed a protocol to implement evidence-based cervical cancer screening and linkage to treatment strategies to the rural communities. We describe the protocol for a cluster-randomized trial to compare two implementation strategies for human-papillomavirus (HPV)-based cervical cancer screening program using metrics described in the RE-AIM (reach, efficacy, adaption, implementation and maintenance) framework...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207620/txndc5-is-a-cervical-tumor-susceptibility-gene-that-stimulates-cell-migration-vasculogenic-mimicry-and-angiogenesis-by-down-regulating-serpinf1-and-traf1-expression
#6
Bing Xu, Jian Li, Xiaoxin Liu, Chang Li, Xiaotian Chang
TXNDC5 (thioredoxin domain-containing protein 5) catalyzes disulfide bond formation, isomerization and reduction. Studies have reported that TXNDC5 expression is increased in some tumor tissues and that its increased expression can predict a poor prognosis. However, the tumorigenic mechanism has not been well characterized. In this study, we detected a significant association between the rs408014 and rs7771314 SNPs at the TXNDC5 locus and cervical carcinoma using the Taqman genotyping method. We also detected a significantly increased expression of TXNDC5 in cervical tumor tissues using immunohistochemistry and Western blot analysis...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207048/tlr4-promotes-the-expression-of-hif-1%C3%AE-by-triggering-reactive-oxygen-species-in-cervical-cancer-cells-in%C3%A2-vitro-implications-for-therapeutic-intervention
#7
Xiao Yang, Gan Tao Chen, Yan Qing Wang, Shu Xian, Li Zhang, Shao Ming Zhu, Feng Pan, Yan Xiang Cheng
The present study investigated the mechanism underlying Toll-like receptor 4 (TLR4)-mediated stimulation of hypoxia-inducible factor-1α (HIF-1α) activity and its association with reactive oxygen species (ROS) in cervical cancer cells. SiHa cells were cultured and randomized to control, lipopolysaccharide (LPS), methyl-β-cyclodextrin (MβCD)+LPS, ammonium pyrrolidinedithiocarbamate (PDTC)+LPS, ST2825+LPS and small interfering (si) RNA TLR4+LPS treatment groups. Cell proliferation was quantified using an MTT assay, cell cloning was performed using soft agar colony formation and HIF-1α expression was detected by immunocytochemical staining and western blot analyses...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29206085/reduction-in-the-burden-of-hospital-admissions-due-to-cervical-disease-from-2003-2014-in-spain
#8
Noelia López, Ángel Gil-de-Miguel, Raquel Pascual-García, Ruth Gil-Prieto
BACKGROUND: Cervix uteri cancer is the 4th most common cancer among women worldwide and the second most frequent cancer in women under 45 years old in Spain. We aimed to describe the burden of hospital admissions by malignant neoplasia (MN) and in situ carcinoma (ISC) of the cervix in Spain from 2003 to 2014, a 12-year period that included the first years after introduction of an HPV vaccination program. METHODS: This epidemiological study reviewed data from the Ministry of Health National Surveillance System, which includes more than 98% of Spanish hospitals...
December 5, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29205307/the-history-and-use-of-cancer-registry-data-by-public-health-cancer-control-programs-in-the-united-states
#9
Mary C White, Frances Babcock, Nikki S Hayes, Angela B Mariotto, Faye L Wong, Betsy A Kohler, Hannah K Weir
Because cancer registry data provide a census of cancer cases, registry data can be used to: 1) define and monitor cancer incidence at the local, state, and national levels; 2) investigate patterns of cancer treatment; and 3) evaluate the effectiveness of public health efforts to prevent cancer cases and improve cancer survival. The purpose of this article is to provide a broad overview of the history of cancer surveillance programs in the United States, and illustrate the expanding ways in which cancer surveillance data are being made available and contributing to cancer control programs...
December 15, 2017: Cancer
https://www.readbyqxmd.com/read/29203054/on-the-search-to-elucidate-the-role-of-the-microbiota-in-the-genesis-of-cancer-the-cases-of-gastrointestinal-and-cervical-cancer
#10
REVIEW
Francisco Avilés-Jiménez, Yu Guogin, Kirvis Torres-Poveda, Vicente Madrid-Marina, Javier Torres
The microbiota that inhabits the human body plays an important role in health and disease, by their fundamental role in food digestion, training of the immune system or protection against pathogen colonization. However, when the equilibrium with its host is altered, some diseases like cancer might be promoted. In this review we describe the information collected in recent studies between the microbiota and its association with cancer. We conducted the review of the relation of microbiome and cancer etiology focusing on the gastrointestinal and cervical cancer...
December 1, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29197067/cervical-cancer-screening-through-human-papillomavirus-testing-in-community-health-campaigns-versus-health-facilities-in-rural-western-kenya
#11
Megan J Huchko, Saduma Ibrahim, Cinthia Blat, Craig R Cohen, Jennifer S Smith, Robert A Hiatt, Elizabeth Bukusi
OBJECTIVE: To determine the effectiveness of community health campaigns (CHCs) as a strategy for human papillomavirus (HPV)-based cervical cancer screening in rural western Kenya. METHODS: Between January and November 2016, a cluster-randomized trial was carried out in 12 communities in western Kenya to investigate high-risk HPV testing offered via self-collection to women aged 25-65 years in CHCs versus government health facilities. Outcome measures were the total number of women accessing cervical cancer screening and the proportion of HPV-positive women accessing treatment...
December 2, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29191437/urinary-diversion-in-the-genitourinary-cancer-survivor
#12
REVIEW
Omari K Johnson, Andrew Berchuck, Angeles A Secord, Andrew C Peterson
Urinary diversion has been in the scope of practice of Gynecologic Oncologists since the inception of the sub-specialty. However, many fewer urinary diversions are performed currently than in the past due to improved prevention of cervical cancer. The intent of this article is to provide a state of the art review for Gynecologic Oncologists. Surgeons performing these complex procedures must be knowledgeable about the differences between various types of continent and non-continent urinary diversions, and the principles of pre and post-operative care...
November 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29185265/epidemiology-of-gynecologic-cancers-in-china
#13
REVIEW
Xiyi Jiang, Huijuan Tang, Tianhui Chen
Cancer has become a major disease burden across the globe. It was estimated that 4.29 million new incident cases and 2.81 million death cases of cancer would occur in 2015 in China, with the age-standardized incidence rate (ASIR) of 201.1 per 100,000 and age-standardized mortality rate (ASMR) of 126.9 per 100,000, respectively. For females, 2 of the top 10 most common types of cancer would be gynecologic cancers, with breast cancer being the most prevalent (268.6 thousand new incident cases) and cervical cancer being the 7th most common cancer (98...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29180927/comparative-efficacy-of-epigallocatechin-3-gallate-against-h2o2-induced-ros-in-cervical-cancer-biopsies-and-hela-cell-lines
#14
Sohail Hussain
Aim of the study: Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells. Material and methods: The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180538/prevalence-and-sociodemographic-correlates-of-cervicovaginal-human-papillomavirus-hpv-carriage-in-a-cross-sectional-multiethnic-community-based-female-asian-population
#15
Su Pei Khoo, Nirmala Bhoo-Pathy, Siew Hwei Yap, Mohd Khairul Anwar Shafii, Nazrilla Hairizan Nasir, Jerome Belinson, ShriDevi Subramaniam, Pik Pin Goh, Ming Zeng, Hong Dong Tan, Patti Gravitt, Yin Ling Woo
OBJECTIVES: Cervical cancer is a largely preventable disease, and the strategic implementation of a cervical cancer prevention programme is partly dependent on the impact of human papillomavirus (HPV) infection interpreted within the context of the country's sociodemographic attributes. The objective of this study is to determine the prevalence of cervicovaginal HPV infection among a healthy, community-based, multiethnic Malaysian population. The HPV prevalence was subsequently correlated to the individual's sociodemographics and sexual/reproductive history...
November 27, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29179869/overcoming-barriers-in-hpv-vaccination-and-screening-programs
#16
Alex Vorsters, Marc Arbyn, Marc Baay, Xavier Bosch, Silvia de Sanjosé, Sharon Hanley, Emilie Karafillakis, Pier Luigi Lopalco, Kevin G Pollock, Joanne Yarwood, Pierre Van Damme
The Human Papillomavirus Prevention and Control Board brought together experts to discuss optimizing HPV vaccination and screening programs. Board members reviewed the safety profile of licensed HPV vaccines based on clinical and post-marketing data, reaching a consensus that current safety data is reassuring. Successful vaccination programs used well-coordinated communication campaigns, integrating (social) media to spread awareness. Communication of evidence supporting vaccine effectiveness had beneficial effects on the perception of the vaccine...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29168085/prevalence-of-human-papillomavirus-genotypes-and-abnormal-pap-smears-among-women-in-the-military-health-system
#17
Christopher M Daly, Shana L Hansen, Paul O Kwon, Timothy A Roberts
Human papillomavirus infection (HPV) is the most common sexually transmitted infection among United States Military Servicemembers, and present in the majority of cervical cancers. Many of these infections are preventable, but HPV immunization is not mandatory during military service. The objective of this study was to examine the prevalence of vaccine-preventable cervical disease among women enrolled in the San Antonio Military Health System. This is a retrospective cross-sectional study of Pap smear results and HPV genotyping data among Military Servicewomen and beneficiaries...
November 22, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/29161240/rapid-nodal-staging-of-head-and-neck-cancer-surgical-specimens-with-flow-cytometric-analysis
#18
Valtteri Häyry, Åsa Kågedal, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Eva Munck-Wikland, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Each lymph node was divided in two, one half processed for histopathology and the other half dissociated into single-cell suspension, stained for the carcinoma cell markers cytokeratin 5/8 (CK5/8), epithelial cell adhesion molecule (EpCAM) and epithelial mucin (MUC-1), and analysed with flow cytometry...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#19
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29158964/ginsenoside-rk1-bioactivity-a-systematic-review
#20
Abdelrahman Elshafay, Ngo Xuan Tinh, Samar Salman, Yara Saber Shaheen, Eman Bashir Othman, Mohamed Tamer Elhady, Aswin Ratna Kansakar, Linh Tran, Le Van, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 and were published up to July 2017 with no restriction on language or study design. Out of the 156 papers identified, we retrieved 28 eligible papers in the first skimming phase of research...
2017: PeerJ
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