Lydia Giannitrapani, Francesca Di Gaudio, Melchiorre Cervello, Francesca Scionti, Domenico Ciliberto, Nicoletta Staropoli, Giuseppe Agapito, Mario Cannataro, Pierfrancesco Tassone, Pierosandro Tagliaferri, Aurelio Seidita, Maurizio Soresi, Marco Affronti, Gaetano Bertino, Maurizio Russello, Rosaria Ciriminna, Claudia Lino, Francesca Spinnato, Francesco Verderame, Giuseppa Augello, Mariamena Arbitrio
The identification of biomarkers for predicting inter-individual sorafenib response variability could allow hepatocellular carcinoma (HCC) patient stratification. SNPs in angiogenesis- and drug absorption, distribution, metabolism, and excretion (ADME)-related genes were evaluated to identify new potential predictive biomarkers of sorafenib response in HCC patients. Five known SNPs in angiogenesis-related genes, including VEGF-A , VEGF-C , HIF-1a , ANGPT2 , and NOS3 , were investigated in 34 HCC patients (9 sorafenib responders and 25 non-responders)...
February 12, 2024: International Journal of Molecular Sciences