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Dermatology and stem cells

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https://www.readbyqxmd.com/read/29623021/biochemical-aspects-of-mammalian-melanocytes-and-the-emerging-role-of-melanocyte-stem-cells-in-dermatological-therapies
#1
REVIEW
Sharique A Ali, Ishrat Naaz
Skin color in animals is richer than human beings and is determined by different types of pigments. Melanin is the key pigment responsible for the diverse pigmentation found in animal and human skin, hair, and eyes. Melanin pigment is synthesized by melanocytes and is consecutively transferred to adjacent keratinocytes; here, it acts as an internal sunscreen to defend from ultraviolet (UV) damage. Any defect in the process of melanocytes development and/or melanin synthesis results in esthetic problem of abnormal pigmentation...
January 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29536565/chronic-cutaneous-graft-versus-host-disease-in-children-a-report-of-14-patients-from-a-tertiary-care-pediatric-dermatology-clinic
#2
Arti Nanda, Maitham A A Husain, Waleed Al-Herz, Adla Almekaimi, Humoud Al-Sabah, Mohammad Al-Otaibi
BACKGROUND/OBJECTIVES: Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment option for many life-threatening disorders in children. Chronic graft-versus-host disease (cGVHD) is a significant complication of HSCT, and its treatment is challenging. Skin is the most common organ affected in cGVHD, with protean manifestations posing a challenge in diagnosis and management. The objective was to have a better understanding of the spectrum of chronic cutaneous GVHD (cc-GVHD) in children...
March 14, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29529112/regenerative-medicine-in-cosmetic-dermatology
#3
Sucharita Boddu, Peter W Hashim, John K Nia, Rebecca Horowitz, Aaron Farberg, Gary Goldenberg
Stem cell therapies are at the forefront of regenerative aesthetic medicine. Multipotent stem cells and induced pluripotent stem cells (iPSCs), progenitor cells that result from the dedifferentiation of specialized adult cells, have demonstrated promise in tissue regeneration for a wide range of dermatologic conditions and aesthetic applications. Herein, we review the potential of stem cells as a new frontier in aesthetic dermatology.
January 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29503540/-origanum-vulgare-mediated-green-synthesis-of-biocompatible-gold-nanoparticles-simultaneously-possessing-plasmonic-antioxidant-and-antimicrobial-properties
#4
Daniela Benedec, Ilioara Oniga, Flavia Cuibus, Bogdan Sevastre, Gabriela Stiufiuc, Mihaela Duma, Daniela Hanganu, Cristian Iacovita, Rares Stiufiuc, Constantin Mihai Lucaciu
Purpose: The leaves and flowering stem of Origanum vulgare contain essential oils, flavonoids, phenolic acids and anthocyanins. We propose a new, simple, one-pot, O. vulgare extract (OVE) mediated green synthesis method of biocompatible gold nanoparticles (AuNPs) possessing improved antioxidant, antimicrobial and plasmonic properties. Materials and methods: Different concentrations of OVEs were used to reduce gold ions and to synthetize biocompatible spherical AuNPs...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29478615/neurofibromatosis-type-1
#5
Patrick J Cimino, David H Gutmann
The neurofibromatoses are a group of three heterogeneous disorders that include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis. NF1 is the most common of these three conditions, and represents one of the most frequently diagnosed cancer predisposition disorders involving the nervous system. While NF1 primarily affects the central and peripheral nervous system, multisystem involvement is the rule, with dermatologic, cardiovascular, gastrointestinal, and orthopedic affectation often reported...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29422816/the-use-of-stem-cells-in-aesthetic-dermatology-and-plastic-surgery-procedures-a-compact-review-of-experimental-and-clinical-applications
#6
Maciej Nowacki, Tomasz Kloskowski, Katarzyna Pietkun, Maciej Zegarski, Marta Pokrywczyńska, Samy L Habib, Tomasz Drewa, Barbara Zegarska
The aim of this paper was to collect currently available data related to the use of stem cells in aesthetic dermatology and plastic surgery based on a systemic review of experimental and clinical applications. We found that the use of stem cells is very promising but the current state of art is still not effective. This situation is connected with not fully known mechanisms of cell interactions, possible risks and side effects. We think that there is a big need to create and conduct different studies which could resolve problems of stem cells use for implementation into aesthetic dermatology and plastic surgery...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29389549/stem-cell-therapy-on-skin-mechanisms-recent-advances-and-drug-reviewing-issues
#7
REVIEW
Gong-Yau Chu, Yu-Fu Chen, Hsiao-Yun Chen, Ming-Hsiao Chan, Churn-Shiouh Gau, Shih-Ming Weng
Stem cell products and its clinical applications have been widely discussed in recent years, particularly when the Japanese "induced pluripotent stem cells" founder Dr. Yamanaka was awarded as Nobel Prize laureate in 2013. For decades, major progresses have been achieved in the stem cell biology field, and more and more evidence showed that skin stem cells are involved in the process of skin repair. Stem/progenitor cells of the epidermis are recognized to play the most essential role in the tissue regeneration of skin...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29200755/current-and-future-perspectives-of-stem-cell-therapy-in-dermatology
#8
REVIEW
Christine M Prodinger, Julia Reichelt, Johann W Bauer, Martin Laimer
Stem cells are undifferentiated cells capable of generating, sustaining, and replacing terminally differentiated cells and tissues. They can be isolated from embryonic as well as almost all adult tissues including skin, but are also generated through genetic reprogramming of differentiated cells. Preclinical and clinical research has recently tremendously improved stem cell therapy, being a promising treatment option for various diseases in which current medical therapies fail to cure, prevent progression or relieve symptoms...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28962889/a-new-clerodane-furano-diterpene-glycoside-from-tinospora-cordifolia-triggers-autophagy-and-apoptosis-in-hct-116-colon-cancer-cells
#9
Neha Sharma, Ashok Kumar, P R Sharma, Arem Qayum, Shashank K Singh, Prabhu Dutt, Satya Paul, Vivek Gupta, M K Verma, N K Satti, R Vishwakarma
ETHNOPHARMACOLOGICAL RELEVANCE: Tinospora cordifolia is a miraculous ayurvedic herb used in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis, anaemia, rheumatoid arthritis, dermatological diseases, cancer, gout, jaundice, asthma, leprosy, in the treatment of bone fractures, liver & intestinal disorders, purifies the blood, gives new life to the whole body; (rejuvenating herb) and many more. Recent studies have revealed the anticancer potential of this plant but not much work has been done on the anticancer chemical constituents actually responsible for its amazing anticancer effects...
September 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28815175/platelet-rich-plasma-an-elixir-for-treatment-of-alopecia-personal-experience-on-117-patients-with-review-of-literature
#10
REVIEW
Suruchi Garg, Shweta Manchanda
Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28810997/cutaneous-leishmaniasis-in-a-saudi-arabian-soldier-stationed-in-the-united-states
#11
Kelly Laurent, Jason Susong, Eric Fillman, Simon Ritchie
BACKGROUND: Leishmaniasis is a common parasitic disease seen in many parts of the world, especially in areas where current U.S. and international forces are deployed. Approximately 350 million people are thought to be at risk of cutaneous leishmaniasis (CL) with an annual incidence of 1.5 million cases. Over 90% of cutaneous infections with Leishmania occur in the Middle East, Brazil, and Peru. Outbreaks of CL may occur in military personnel deployed to endemic areas. Since the incubation period for symptomatic CL ranges from weeks to months, symptoms may not appear until well after returning to the United States...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28746927/autologous-adipose-tissue-graft-to-treat-hypertensive-leg-ulcer-a-pilot-study
#12
M Chopinaud, D Labbé, C Creveuil, M Marc, H Bénateau, B Mourgeon, E Chopinaud, A Veyssière, A Dompmartin
BACKGROUND: Adipose tissue is an abundant source of mesenchymal stem cells, called adipose-derived stem cells, which have anti-inflammatory and trophic effects to enhance overall tissue repair. OBJECTIVE: To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers. METHODS: Prospective pilot study in 1 French dermatology department. Ten patients with a hypertensive leg ulcer were enrolled from April 2013 to June 2015...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28670356/a-prospective-randomized-double-blind-split-face-clinical-trial-comparing-the-efficacy-of-two-topical-human-growth-factors-for-the-rejuvenation-of-the-aging-face
#13
Douglas C Wu, Mitchel P Goldman
Background: Cosmeceutical products represent an increasingly important therapeutic option for anti-aging and rejuvenation, either used alone or in combination with dermatologic surgical procedures. Among this group of products, topical growth factors have demonstrated efficacy in randomized, controlled clinical trials. However, comparisons between different products remain uncommon. Objective: The objective of this randomized, double-blind, split-face clinical trial was to compare two different topical growth factor formulations derived from either human fibroblasts or human adipose tissue derived mesenchymal stem cells...
May 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28463600/imaging-of-abdominal-and-pelvic-manifestations-of-graft-versus-host-disease-after-hematopoietic-stem-cell-transplant
#14
REVIEW
Meghan G Lubner, Christine O Menias, Michelle Agrons, Kinan Alhalabi, Venkata S Katabathina, Khaled M Elsayes, Perry J Pickhardt
OBJECTIVE: Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant (HSCT). GVHD predominantly affects the skin, gastrointestinal system and hepatobiliary systems. Imaging findings in the gastrointestinal tract include bowel wall thickening with mucosal enhancement, mesenteric edema, and vascular engorgement. In the hepatobiliary system, hepatosplenomegaly, periportal edema, bile duct dilatation, and gallbladder and biliary wall thickening are seen...
July 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28448316/regenerative-medicine-and-stem-cells-in-dermatology
#15
Eduardo K Moioli, Diana Bolotin, Murad Alam
BACKGROUND: Clinically relevant regenerative medicine is still in its early stages of development. Difficulties in regenerating large-scale and complex structures, the lack of safety data, and the paucity of clinical trials have slowed the process of technological advance. OBJECTIVE: To familiarize the clinician with techniques available in the laboratory and experimental approaches being tested clinically. In addition, a layout is discussed for how dermatologists can lead the way in bringing regenerative medicine to clinical reality...
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28441301/regenerative-medicine-and-stem-cells-in-dermatology
#16
REVIEW
Eduardo K Moioli, Diana Bolotin, Murad Alam
BACKGROUND: Clinically relevant regenerative medicine is still in its early stages of development. Difficulties in regenerating large-scale and complex structures, the lack of safety data, and the paucity of clinical trials have slowed the process of technological advance. OBJECTIVE: To familiarize the clinician with techniques available in the laboratory and experimental approaches being tested clinically. In addition, a layout is discussed for how dermatologists can lead the way in bringing regenerative medicine to clinical reality...
May 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28421727/the-epidemic-spreading-of-basal-cell-carcinoma-incidence-trend-demographic-features-characteristics-and-risk-factors-in-a-retrospective-study-of-8557-lesions-in-bologna
#17
Valeria Gaspari, Annalisa Patrizi, Michela Venturi, Cosimo Misciali, Pier A Fanti
BACKGROUND: Basal cell carcinoma (BCC) has a rising incidence worldwide. The aim was to evaluate incidence trend, demographic features and risk factors for BCC in the area of Bologna in northern-central Italy. METHODS: All the consecutive histopathologically diagnosed BCCs at the Dermatology of the Bologna University from 1990 to 2014 were retrospectively reviewed. We evaluated the absolute number of BCCs, the demographic features of patients and the characteristics of BCCs with statistically significant correlations...
April 19, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28416991/can-denosumab-be-a-substitute-competitor-or-complement-to-bisphosphonates
#18
REVIEW
Su Young Kim, Hwoe Gyeong Ok, Christof Birkenmaier, Kyung Hoon Kim
Osteoblasts, originating from mesenchymal cells, make the receptor activator of the nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in order to control differentiation of activated osteoclasts, originating from hematopoietic stem cells. When the RANKL binds to the RANK of the pre-osteoclasts or mature osteoclasts, bone resorption increases. On the contrary, when OPG binds to the RANK, bone resorption decreases. Denosumab (AMG 162), like OPG (a decoy receptor), binds to the RANKL, and reduces binding between the RANK and the RANKL resulting in inhibition of osteoclastogenesis and reduction of bone resorption...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28368380/risk-of-melanocytic-nevi-and-nonmelanoma-skin-cancer-in-children-after-allogeneic-hematopoietic-stem-cell-transplantation
#19
J S Song, W B London, E B Hawryluk, D Guo, M Sridharan, D E Fisher, L E Lehmann, C N Duncan, J T Huang
There is a known increased risk of skin cancer in the adult population after hematopoietic stem cell transplantation (HSCT). However, late dermatologic effects that children may experience after HSCT have not been well described. The primary objective of this study was to characterize nevi and skin cancers affecting children after allogeneic HSCT. A cross-sectional cohort study of 85 pediatric HSCT recipients and 85 controls matched for age, sex and skin phototype was performed at a single institution. All participants underwent a full skin examination...
July 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28262626/properties-of-skin-stem-cells-and-their-potential-clinical-applications-in-modern-dermatology
#20
Anna Niezgoda, Piotr Niezgoda, Laura Nowowiejska, Agnieszka Białecka, Kaja Męcińska-Jundziłł, Urszula Adamska, Rafał Czajkowski
Stem cells play an important role in medical science, and scientists are investing large sums in order to perform sophisticated studies designed to establish potential clinical applications of stem cells. Growing experience has enabled researchers to determine the precise nature of stem cell division. Although the properties of this particular population of cells have been known and used for some time, mainly with regards to bone marrow-derived mesenchymal stem cell transplantation, we now face a significant challenge in implementing the practical use of skin-derived precursors, making it possible to avoid the necessity for patients to undergo invasive procedures in order to obtain stem cells from bone marrow...
March 11, 2017: European Journal of Dermatology: EJD
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