keyword
https://read.qxmd.com/read/38524394/autologous-nanofat-injection-combined-with-fractional-co2-laser-in-the-treatment-of-atrophic-acne-scars
#1
JOURNAL ARTICLE
Mahmoud A Rageh, Shady Mahmoud Attia Ibrahim, Noha Abdallah, Abeer Attia Tawfik
BACKGROUND: Atrophic acne scarring is a widely prevalent condition and one of the most distressing complications of acne vulgaris. Numerous options with variable outcomes are available for the treatment of acne scarring. Laser is considered a first-line therapy for acne scars, and recently there has been a growing interest in using stem cells and their derivatives for treating acne scars. In addition, combined therapeutic modalities often achieve more satisfactory results than a single treatment...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38524392/human-mesenchymal-stem-cell-derived-exosomes-promote-the-proliferation-and-melanogenesis-of-primary-melanocytes-by-attenuating-the-h-2-o-2-related-cytotoxicity-in-vitro
#2
JOURNAL ARTICLE
Yexiao Wang, Zibin He, Bingqin Luo, Hioteng Wong, Liangcai Wu, Hui Zhou
BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-Exo) have therapeutic potential. However, the impact of MSC-Exo on the survival and melanogenesis of human primary melanocytes following H2 O2 -induced damage has not been clarified. We therefore investigated the effects of MSC-Exo on the H2 O2 -affected survival of human primary melanocytes and their proliferation, apoptosis, senescence, and melanogenesis in vitro. METHODS: MSC-Exo were prepared from human MSCs by sequential centrifugations and characterized by Transmission Electron Microscopy, Western blot and Nanoparticle Tracking Analysis...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38521704/follicular-unit-grafting-in-chronic-ulcers-a-valuable-technique-for-integrated-management
#3
JOURNAL ARTICLE
Anahi Belatti, Florencia Bertarini, Virginia Pombo, Luis Mazzuoccolo, Damian Ferrario
Chronic ulcers significantly affect the quality of life of patients and impose a high cost on the healthcare system. The therapeutic management should be comprehensive, taking into consideration the etiological diagnosis of the wound and the characteristics of the wound bed when deciding on a therapeutic proposal appropriate to the healing phase, correcting factors that delay healing. During the epithelialization phase, repair techniques with grafts are recommended to shorten re-epithelialization time, improve the quality of scar tissue, and achieve adequate pain management...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38494614/an-atlas-of-the-human-nail
#4
JOURNAL ARTICLE
Nardo Zaias
Dermatologic literature describes nail abnormalities involving nail bed as linear erythronychia or onychomatricoma. The abnormality reflects cognitive content of the nail bed. A resourceful epidermis capable of manifesting in a variety of clinical appearances depends on initiating stimulus affecting remarkably its nail bed matrix cells. These cells are stem cells (NBMSC) migrating distally to cover remarkably the underlying nail bed dermal ridges that are homologous to finger print dermal ridges. Normally, adult nail bed epidermal cells are uniform and keratinize with the stratum corneum without a granular layer...
2024: Skinmed
https://read.qxmd.com/read/38487264/translational-frontiers-insight-from-lymphatics-in-skin-regeneration
#5
REVIEW
Yujia Jiang, Mirna Perez-Moreno
The remarkable regenerative ability of the skin, governed by complex molecular mechanisms, offers profound insights into the skin repair processes and the pathogenesis of various dermatological conditions. This understanding, derived from studies in human skin and various model systems, has not only deepened our knowledge of skin regeneration but also facilitated the development of skin substitutes in clinical practice. Recent research highlights the crucial role of lymphatic vessels in skin regeneration. Traditionally associated with fluid dynamics and immune modulation, these vessels are now recognized for interacting with skin stem cells and coordinating regeneration...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38481799/exosomes-the-emerging-mechanisms-and-potential-clinical-applications-in-dermatology
#6
REVIEW
Honghao Yu, Heting Feng, Hong Zeng, Yiping Wu, Qi Zhang, Jing Yu, Kai Hou, Min Wu
Skin tissue, composed of epidermis, dermis, and subcutaneous tissue, is the largest organ of the human body. It serves as a protective barrier against pathogens and physical trauma and plays a crucial role in maintaining homeostasis. Skin diseases, such as psoriasis, dermatitis, and vitiligo, are prevalent and can seriously impact the quality of patient life. Exosomes are lipid bilayer vesicles derived from multiple cells with conserved biomarkers and are important mediators of intercellular communication. Exosomes from skin cells, blood, and stem cells, are the main types of exosomes that are involved in modulating the skin microenvironment...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38478637/anti-laminin-332-antibodies-in-graft-versus-host-disease-associated-bullous-pemphigoid-after-allogeneic-peripheral-blood-stem-cell-transplantation
#7
JOURNAL ARTICLE
Yasutoshi Hida, Riho Kageji, Hirofumi Bekku, Norito Ishii
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses...
October 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38474251/the-efficacy-of-stem-cells-in-wound-healing-a-systematic-review
#8
REVIEW
Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai
Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465565/%C3%AE-catenin-activation-in-gli-1-stem-cells-leads-to-reprograming-of-the-hair-follicle
#9
JOURNAL ARTICLE
Jimin Han, Weiwei Chu, Kaijun Lin, Xusheng Wang, Ying Gao
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38463491/therapeutic-potential-of-adipose-derived-stromal-cells-for-major-skin-inflammatory-diseases
#10
REVIEW
Marina Ramírez Galera, Jesper Svalgaard, Anders Woetmann
Inflammatory skin diseases like psoriasis and atopic dermatitis are chronic inflammatory skin conditions continuously under investigation due to increased prevalence and lack of cure. Moreover, long-term treatments available are often associated with adverse effects and drug resistance. Consequently, there is a clear unmet need for new therapeutic approaches. One promising and cutting-edge treatment option is the use of adipose-derived mesenchymal stromal cells (AD-MSCs) due to its immunomodulatory and anti-inflammatory properties...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38462125/spry1-deficiency-in-keratinocytes-induces-follicular-melanocyte-stem-cells-migration-to-epidermis-through-p53-scf-c-kit-signaling
#11
JOURNAL ARTICLE
Ying-Zhe Cui, Fan Xu, Yuan Zhou, Zhao-Yuan Wang, Xing-Yu Yang, Ni-Chang Fu, Xi-Bei Chen, Yu-Xin Zheng, Xue-Yan Chen, Li-Ran Ye, Ying-Ying Li, Xiao-Yong Man
The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes. Keratinocytes and melanocytes respond to UV exposure by eliciting a tanning response. However, how keratinocytes and melanocytes interact in the absence of UV exposure is unknown. Here, we demonstrate that after SPRY1 knockout in epidermal keratinocytes, melanocyte stem cells (McSCs) in the hair follicle exit the niche without depleting the pool of these cells. We also found that McSCs migrate to the epidermis in a p53/SCF/C-KIT-dependent manner induced by a tanning-like response resulting from SPRY1 loss in epidermal keratinocytes...
March 8, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38431220/embryonic-nipp1-depletion-in-keratinocytes-triggers-a-cell-cycle-arrest-and-premature-senescence-in-adult-mice
#12
JOURNAL ARTICLE
Marloes C M Jonkhout, Tijs Vanhessche, Mónica Ferreira, Iris Verbinnen, Fabienne Withof, Gerd Van der Hoeven, Kathelijne Szekér, Zahra Azhir, Wen-Hui Lien, Aleyde Van Eynde, Mathieu Bollen
NIPP1 is a ubiquitously expressed regulatory subunit of protein phosphatase-1. Its embryonic deletion in keratinocytes causes chronic sterile skin inflammation, epidermal hyperproliferation and resistance to mutagens in adult mice. To explore the primary effects of NIPP1 deletion, we first examined hair-cycle progression of NIPP1 skin knockouts (SKOs). The entry of the 1st hair cycle in the SKOs was delayed due to prolonged quiescence of hair-follicle stem cells (HFSCs). In contrast, the entry of the 2nd hair cycle in the SKOs was advanced as a result of precocious activation of HFSCs...
February 29, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38429917/higher-percentage-of-cd34-stem-cells-and-elevated-efficacy-in-androgenetic-alopecia-treatment-observed-in-cgf-prepared-from-640%C3%A2-nm-laser-pretreated-blood-a-preliminary-study
#13
JOURNAL ARTICLE
Jin Gao, Qin Xiao, Yongzhou Lu, Jing Guo, Dongdong Luan, Chuanlong Jia, Qiannan Xu, Nan Xu
BACKGROUND: Concentrated growth factor (CGF) injection has proven effective in treating androgenetic alopecia (AGA). The primary mechanism of CGF in treating AGA is thought to be the CD34+ stem cells and platelets-associated growth factors being injected into the scalp. CGF efficacy in treating AGA may rely on the activation level of these stem cells and platelets. The 640 nm laser is a United States Food and Drug Administration approved AGA treatment that activates follicle stem cells...
March 1, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38429909/adipose-stem-cell-derived-exosomes-promote-wound-healing-by-regulating-the-let-7i-5p-gas7-axis
#14
JOURNAL ARTICLE
Xiaosong Liu, Biao Wang
BACKGROUND: Injury to skin tissue is devastating for human health, making it imperative to devise strategies for hastening wound healing. Normal wound healing is a complex process comprising overlapping steps, including hemostasis, inflammatory response, proliferation, and matrix remodeling. This study investigated the effects of adipose stem cell-derived exosomes (ADSC-exos) on wound healing and the underlying mechanisms. METHODS: In vitro hydrogen peroxide (H2 O2 )-treated human keratinocyte (HaCaT) cell lines and in vivo animal wound models were established for this purpose...
March 1, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38419202/alterations-in-epidermal-stem-cells-within-the-pilosebaceous-unit-in-atrophic-acne-scars
#15
JOURNAL ARTICLE
Dong Hyo Kim, Ji Young Yoon, Jun Hyo Lee, Dae Hun Suh
BACKGROUND: Atrophic acne scarring is a common sequela of inflammatory acne, causing significant problems for affected patients. Although prolonged inflammation and subsequent aberrant tissue regeneration are considered the underlying pathogenesis, the role of epidermal stem cells, which are crucial to the regeneration of pilosebaceous units, remains unknown. OBJECTIVES: To examine the changes occurring in epidermal stem cells in atrophic acne scars. METHODS: Changes in collagen, elastic fibre and human leukocyte antigen (HLA)-DR expression were analysed in normal skin and inflammatory acne lesions at days 1, 3 and 7 after development...
February 28, 2024: Australasian Journal of Dermatology
https://read.qxmd.com/read/38382868/klf2-orchestrates-pathological-progression-of-infantile-hemangioma-through-hemangioma-stem-cell-fate-decisions
#16
JOURNAL ARTICLE
Qiming Chen, Hao Rong, Ling Zhang, Yanan Wang, Qian Bian, Jiawei Zheng
Infantile hemangioma (IH) is the most prevalent vascular tumor during infancy, characterized by a rapid proliferation phase of disorganized blood vessels and spontaneous involution. IH possibily arises from a special type of multipotent stem cells called hemangioma stem cells (HemSCs), which could differentiate into endothelial cells, pericytes, and adipocytes. However, the underlying mechanisms that regulate the cell fate determination of HemSCs remain elusive. Here, we unveil KLF2 as a candidate transcription factor involved in the control of HemSCs differentiation...
February 19, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38381230/the-role-of-laser-and-energy-assisted-drug-delivery-in-the-treatment-of-alopecia
#17
REVIEW
Eliza Balazic, Ahava Muskat, Yana Kost, Joel L Cohen, Kseniya Kobets
It has been recently established that laser treatment can be combined with topical or intralesional medications to enhance the delivery of drugs and improve overall results in a variety of different dermatological disorders. The aim of this review is to evaluate the use of laser and energy-assisted drug delivery (LEADD) for the treatment of alopecia with a specific focus on ablative fractional lasers (AFL), non-ablative fractional lasers (NAFL), and radiofrequency microneedling (RFMN). A comprehensive PubMed search was performed in December 2022 for "laser-assisted drug delivery" as well as "laser" and "alopecia...
February 21, 2024: Lasers in Medical Science
https://read.qxmd.com/read/38366835/macrophages-dampen-skin-inflammation-after-stem-cell-transplantation
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 16, 2024: British Journal of Dermatology
https://read.qxmd.com/read/38353352/characteristics-of-dermal-vascularity-in-melasma-and-solar-lentigo
#19
REVIEW
Yusuke Hara, Takako Shibata
BACKGROUND /PURPOSE: Melasma and solar lentigo (SL) are major benign hyperpigmented lesions, and both have been shown to involve the dermal vasculature. This review discusses current knowledge regarding the clinical characteristics of dermal vascularity in melasma and SL, as well as the results of relevant molecular biological investigations. METHODS: PubMed and Google Scholar were searched in December 2023 to identify articles related to melasma, SL, and the dermal vasculature in these lesions...
March 2024: Photodermatology, Photoimmunology & Photomedicine
https://read.qxmd.com/read/38299936/mesenchymal-stem-cell-extracellular-vesicles-as-a-new-treatment-paradigm-in-solid-abdominal-organ-transplantation-a-case-series
#20
JOURNAL ARTICLE
Amy L Lightner, Masato Fujiki, Mohamed Elshawy, Neda Dadgar, Anita Barnoski, Mohammed Osman, Clifton Fulmer, Anil Vaidya
Solid abdominal organ transplantation is fraught with variable rates of rejection and graft versus host disease. We sought to determine the safety and efficacy of an advanced extracellular vesicle (EV) investigational product (IP) derived from mesenchymal stem cells (MSC) in the transplant patient population. Seven separate eINDs were filed with the FDA for the emergency treatment of rejection of an isolated intestinal graft (n=2), liver allograft graft (n=2), modified multivisceral graft (n=3), and GVHD in isolated intestinal transplant patients (n=2)...
February 1, 2024: Stem Cells and Development
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