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Dermatology and stem cells

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https://www.readbyqxmd.com/read/28262626/properties-of-skin-stem-cells-and-their-potential-clinical-applications-in-modern-dermatology
#1
Anna Niezgoda, Piotr Niezgoda, Laura Nowowiejska, Agnieszka Białecka, Kaja Męcińska-Jundziłł, Urszula Adamska, Rafał Czajkowski
Stem cells play an important role in medical science, and scientists are investing large sums in order to perform sophisticated studies designed to establish potential clinical applications of stem cells. Growing experience has enabled researchers to determine the precise nature of stem cell division. Although the properties of this particular population of cells have been known and used for some time, mainly with regards to bone marrow-derived mesenchymal stem cell transplantation, we now face a significant challenge in implementing the practical use of skin-derived precursors, making it possible to avoid the necessity for patients to undergo invasive procedures in order to obtain stem cells from bone marrow...
March 11, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28255771/amniotic-membrane-in-ophthalmology-properties-preparation-storage-and-indications-for-grafting-a-review
#2
REVIEW
Katerina Jirsova, Gary L A Jones
The use of amniotic membrane in ophthalmic surgery and other surgical procedures in the fields of dermatology, plastic surgery, genitourinary medicine and otolaryngology is on the increase. Furthermore, amniotic membrane and its epithelial and mesenchymal cells have broad use in regenerative medicine and hold great promise in anticancer treatment. Amniotic membrane is a rich source of biologically active factors and as such, promotes healing and acts as an effective material for wound dressing. Amniotic membrane supports epithelialization and exhibits anti-fibrotic, anti-inflammatory, anti-angiogenic and anti-microbial features...
March 2, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28247033/influence-of-cyp2c19-2-17-genotype-on-adverse-drug-reactions-of-voriconazole-in-patients-after-allo-hsct-a-four-case-report
#3
Sienkiewicz Beata, Urbaniak-Kujda Donata, Dybko Jarosław, Wróbel Tomasz, Wiela-Hojeńska Anna
PURPOSE: Voriconazole (VCZ) is a new-generation triazol antifungal agent. CYP2C19 mutations have been reported to cause variability in VCZ pharmacokinetics, and thus lead to undesirable effects of pharmacotherapy. We observed four Caucasian patients who underwent allogenic hematopoietic stem cell transplantation, treated with voriconazole for prevention of fungal infections, to establish the impact of CYP2C19*2/*17 genotype on side effect occurrence. METHODS: Genetic testing for CYP2C19 allele*2 and*17 was performed using two PCR-RFLP methods established by Goldstein and Blaisdell, and Sim et al...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28120532/extracellular-nucleotide-hydrolysis-in-dermal-and-limbal-mesenchymal-stem-cells-a-source-of-adenosine-production
#4
Liliana I Sous Naasani, Cristiano Rodrigues, Rafael Paschoal de Campos, Liziane Raquel Beckenkamp, Isabele C Iser, Ana Paula Santin Bertoni, Márcia R Wink
Human Limbal (L-MSCs) and Dermal Mesenchymal Stem Cell (D-MSCs) possess many properties that increase their therapeutic potential in ophthalmology and dermatology. It is known that purinergic signaling plays a role in many aspects of mesenchymal stem cells physiology. They release and respond to purinergic ligands, altering proliferation, migration, differentiation and apoptosis. Therefore, more information on these processes would be crucial for establishing future clinical applications using their differentiation potential, but without undesirable side effects...
January 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28117680/mesenchymal-stem-cells-from-adipose-tissue-in-clinical-applications-for-dermatological-indications-and-skin-aging
#5
REVIEW
Meenakshi Gaur, Marek Dobke, Victoria V Lunyak
Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs) communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging...
January 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28061966/new-treatments-for-hair-loss
#6
S Vañó-Galván, F Camacho
The treatment of hair loss is an important part of clinical dermatology given the prevalence of the problem and great impact on patients' quality of life. Many new treatments have been introduced in recent years. This review summarizes the main ones in 4 groups: a) For androgenetic alopecia, we discuss new excipients for oral minoxidil, dutasteride, and finasteride as well as new forms of topical application; prostaglandin agonists and antagonists; low-level laser therapy; and regenerative medicine with Wnt signaling activators and stem cell therapy...
January 3, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28028989/thymosin-%C3%AE-as-an-actin-binding-protein-with-a-variety-of-functions
#7
REVIEW
Aleksandra Kuzan
According to current data, the thymosin β family is composed of 20 short (40-44 amino acid) peptides, but in a healthy human body only 2 are expressed - thymosin β4 and β10. Their most characteristic feature is the ability to form a complex with monomeric actin, thereby preventing polymerization into a filamentous form, hence the name Actin-Binding Protein (ABP). These peptides play numerous different functions. Among others, they affect the processes of carcinogenesis, differentiation and angiogenesis, influence metalloproteinase activity and accelerate wound healing...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#8
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27851860/dermatopulmonary-syndrome-associated-with-anti-mda5-antibodies-after-allogeneic-hematopoietic-stem-cell-transplantation
#9
Clémence Lepelletier, Djaouida Bengoufa, Zeltni Lyes, Adèle de Masson, François Chasset, Marie Jachiet, David Michonneau, Marie Robin, Régis Peffault de Latour, Flore Sicre de Fontbrune, Yacine Tandjaoui-Lambiotte, Armand Bensussan, Michel Rybojad, Abdellatif Tazi, Martine Bagot, Gérard Socié, Anne Bergeron, Jean-David Bouaziz
Importance: Chronic graft-vs-host-disease (cGVHD) after allogeneic stem cell transplantation (AHSCT) may resemble autoimmune diseases. Anti-MDA5 (melanoma differentiation-associated gene 5) dermatopulmonary syndrome is a subset of dermatomyositis defined by specific clinical features and detection of anti-MDA5-antibodies in the serum. Objective: To characterize the clinical features of patients who underwent AHSCT and screened positively for anti-MDA5 antibodies...
November 16, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27816394/epidermal-yap2-5sa-%C3%AE-c-drives-%C3%AE-catenin-activation-to-promote-keratinocyte-proliferation-in-mouse-skin-in%C3%A2-vivo
#10
Bassem Akladios, Veronica Mendoza-Reinoso, Michael S Samuel, Edna C Hardeman, Kiarash Khosrotehrani, Brian Key, Annemiek Beverdam
The epidermis is a highly regenerative tissue. YAP is a pivotal regulator of stem/progenitor cells in tissue regeneration, including in the epidermis. The molecular mechanisms downstream of YAP that activate epidermal cell proliferation remain largely unknown. We found that YAP and β-catenin co-localize in the nuclei of keratinocytes in the regenerating epidermis in vivo and in proliferating HaCaT keratinocytes in vitro. Inactivation of YAP in HaCaT keratinocytes resulted in reduced activated β-catenin and reduced keratinocyte numbers in vitro...
March 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27803921/use-of-adipose-derived-stem-cells-to-support-topical-skin-adhesive-for-wound-closure-a-preliminary-report-from-animal-in-vivo-study
#11
Maciej Nowacki, Katarzyna Pietkun, Arkadiusz Jundziłł, Tomasz Kloskowski, Dariusz Grzanka, Joanna Skopinska-Wisniewska, Kinga Scibior, Maciej Gagat, Marta Pokrywczyńska, Alina Grzanka, Wojciech Zegarski, Rafał Czajkowski, Tomasz Drewa, Barbara Zegarska
The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27796896/the-cutaneous-telocytes
#12
Catalin G Manole, Olga Simionescu
Telocytes (TCs) are interstitial cells found in stroma of many organs, including the skin dermis. Ultrastructurally, normal skin TCs recapitulates all the previously documented features in interstitum of other organs. Their (ultra)structural hallmark is the presence of particular shaped cellular prolongations (termed telopodes), along other features as cellular organelles representation and their distribution within cell body and its prolongations. Transmission electron microscopy (TEM) or high magnification light microscopy indicated that the particular shape of telopodes alternate characteristically thin segments (termed podomeres) and dilated segments (called podoms)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27762455/systemic-mastocytosis-in-adults-2017-update-on-diagnosis-risk-stratification-and-management
#13
Animesh Pardanani
Disease overview:Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extra-cutaneous organs. DIAGNOSIS: The major criterion is presence of multifocal clusters of morphologically abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC expression of CD25 and/or CD2, and presence of KITD816V. Risk stratification: The 2008 World Health Organization (WHO) classification of SM has been shown to be prognostically relevant...
November 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27613389/genetics-of-syndromic-and-non-syndromic-hereditary-nail-disorders
#14
Christina Bergqvist, Paul Ramia, Ossama Abbas, Mazen Kurban
The nail is a unique epithelial skin appendage made up of a fully keratinized nail plate. The nail can be affected in several systemic illnesses, dermatological diseases, and inherited nail disorders. Nail dystrophies can present as isolated disorders or as a part of syndromes. Substantial progress has been achieved in the management and diagnosis of nail diseases; however, not much is known about the underlying molecular controls of nail growth. The homeostasis and development of the nail appendage depends on the intricate interactions between the epidermis and underlying mesenchyme, and comprises different signaling pathways such as the WNT signaling pathway...
September 10, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27457874/-guidelines-for-vaccination-of-immunocompromised-individuals
#15
Ursula Wiedermann, Harald H Sitte, Heinz Burgmann, Alexander Eser, Petra Falb, Heidemarie Holzmann, Maria Kitchen, Marcus Köller, Herwig Kollaritsch, Michael Kundi, Hans Lassmann, Ingomar Mutz, Winfried F Pickl, Elisabeth Riedl, Maria Sibilia, Florian Thalhammer, Barbara Tucek, Werner Zenz, Karl Zwiauer
Immunosuppression of various origins is associated with an increased risk of infection; therefore the prevention of infectious diseases by vaccination is especially important in immunocompromised patients. However, the response to vaccinations is often reduced in these risk groups and the application of live vaccines is contraindicated during immunosuppression.In the following expert statement, recommendations for vaccination were created on the basis of current evidence and theoretical/immunological considerations...
August 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27422482/in-situ-production-of-ros-in-the-skin-by-photodynamic-therapy-as-a-powerful-tool-in-clinical-dermatology
#16
Pablo Fonda-Pascual, Oscar M Moreno-Arrones, Adrian Alegre-Sanchez, David Saceda-Corralo, Diego Buendia-Castaño, Cristina Pindado-Ortega, Pablo Fernandez-Gonzalez, Kyra Velazquez-Kennedy, María I Calvo-Sánchez, Antonio Harto-Castaño, Bibiana Perez-Garcia, Lorea Bagazgoitia, Sergio Vaño-Galvan, Jesus Espada, Pedro Jaen-Olasolo
Photodynamic therapy (PDT) is a clinical modality of photochemotherapy based on the accumulation of a photosensitizer in target cells and subsequent irradiation of the tissue with light of adequate wavelength promoting reactive oxygen species (ROS) formation and cell death. PDT is used in several medical specialties as an organ-specific therapy for different entities. In this review we focus on the current dermatological procedure of PDT. In the most widely used PDT protocol in dermatology, ROS production occurs by accumulation of the endogenous photosensitizer protoporphyrin IX after treatment with the metabolic precursors 5-methylaminolevulinic acid (MAL) or 5-aminolevulinic acid (ALA)...
July 12, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27394438/platelet-rich-plasma-prp-and-adipose-derived-mesenchymal-stem-cells-stimulatory-effects-on-proliferation-and-migration-of-fibroblasts-and-keratinocytes-in-vitro
#17
Talita Stessuk, Maria Beatriz Puzzi, Elinton Adami Chaim, Paulo César Martins Alves, Erich Vinicius de Paula, Andresa Forte, Juliana Massae Izumizawa, Carolina Caliári Oliveira, Fernando Frei, João Tadeu Ribeiro-Paes
The clinical use of tissue engineering associated with cell therapy is considered a new alternative therapy for the repair of chronic lesions with potential application in different medical areas, mostly in orthopedic and dermatological diseases. Platelet-rich plasma (PRP) is a rich source of growth factors and cytokines important for wound healing. Adipose-derived mesenchymal stem cells (ADSCs) have shown potential to accelerate the resolution of ulcers, to stimulate cell proliferation, and to benefit the quality of skin repair...
September 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27181904/-autologous-fat-grafting-in-scar-revision
#18
REVIEW
Pan-xi Yu, Jing-long Cai
Regenerative medicine is an emerging discipline. Adipose tissue is a rich source of fat cells and mesenchymal stem cells, and autologous fat grafting has increasingly been applied in plastic surgeries and dermatological treatments. This paper reviews the latest advances in autologous fat grafting in scar revision.
April 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27114263/anatomical-patterns-of-infantile-hemangioma-ih-of-the-extremities-ihe
#19
Antonia Reimer, Maren Fliesser, Peter H Hoeger
BACKGROUND: From 18% to 30% of infantile hemangiomas (IH) are located on the extremities (IHE). They can be divided into localized, segmental, and minimal or arrested growth (IH-MAG) subtypes. OBJECTIVE: We sought to correlate localization of IHE with the anatomy of the arterial vascular supply. METHODS: All children with segmental IHE and IH-MAG presenting to our department of pediatric dermatology from 2002 to 2015 were evaluated. Hemangiomas were mapped and their patterns were analyzed...
September 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26861986/effects-of-hair-removal-alexandrite-laser-on-biometric-parameters-of-the-skin
#20
Shiva Alavi, Ehsan Abolhasani, Mohammadali Nilforoushzadeh
The effects of alexandrite laser (AL) on skin parameters such as melanin content, skin layer depth, elasticity, and density have not been investigated through biometric methods. We aim to assess the effect of AL on the skin parameters through biometric devices to determine whether it has positive effects on treated region. In this pretest-posttest study, we recruited patients who attended Laser Clinic of Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran, from January through December 2014...
April 2016: Lasers in Medical Science
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