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transcranial neuromodulation

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https://www.readbyqxmd.com/read/29785673/the-impact-of-transcranial-direct-current-stimulation-tdcs-on-bipolar-depression-mania-and-euthymia-a-systematic-review-of-preliminary-data
#1
Clément Dondé, Nicholas H Neufeld, Pierre A Geoffroy
The neurobiological basis of bipolar disorders (BD) has received increased attention and several brain regions and brain circuits have been correlated with clinical symptoms. These brain regions and circuits may represent targets for neuromodulation techniques such as transcranial Direct Current Stimulation (tDCS). We systematically reviewed the literature to explore the risks and benefits of tDCS in BD and examined all mood states. Following the PRISMA guidelines, a systematic literature search using several databases was performed from April 2002 to June 2017...
May 21, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29784589/tolerability-and-blinding-of-4x1-high-definition-transcranial-direct-current-stimulation-hd-tdcs-at-two-and-three-milliamps
#2
Jaclyn Reckow, Annalise Rahman-Filipiak, Sarah Garcia, Stephen Schlaefflin, Oliver Calhoun, Alexandre F DaSilva, Marom Bikson, Benjamin M Hampstead
BACKGROUND: Transcranial direct current stimulation (tDCS) is an in-demand form of neuromodulation generally regarded as safe and well tolerated. However, few studies have examined the safety, tolerability, or blinding of High Definition (HD-) tDCS, especially in older adults and at stimulation intensities of 2 milliamps (mA) or greater. OBJECTIVE: We examined the rates of serious adverse events and common side effects to establish safety and tolerability, respectively, in HD-tDCS...
May 4, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29784588/brain-stimulation-patterns-emulating-endogenous-thalamocortical-input-to-parvalbumin-expressing-interneurons-reduce-nociception-in-mice
#3
Yeowool Huh, Dahee Jung, Taeyoon Seo, Sukkyu Sun, Su Hyun Kim, Hyewhon Rhim, Sooyoung Chung, Chong-Hyun Kim, Youngwoo Kwon, Marom Bikson, Yong-An Chung, Jeansok J Kim, Jeiwon Cho
BACKGROUND: The bursting pattern of thalamocortical (TC) pathway dampens nociception. Whether brain stimulation mimicking endogenous patterns can engage similar sensory gating processes in the cortex and reduce nociceptive behaviors remains uninvestigated. OBJECTIVE: We investigated the role of cortical parvalbumin expressing (PV) interneurons within the TC circuit in gating nociception and their selective response to TC burst patterns. We then tested if transcranial magnetic stimulation (TMS) patterned on endogenous nociceptive TC bursting modulate nociceptive behaviors...
May 18, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29770647/neuromodulation-for-tinnitus-treatment-an-overview-of-invasive-and-non-invasive-techniques
#4
REVIEW
Nicole Peter, Tobias Kleinjung
Tinnitus is defined as a perception of sound without any external sound source. Chronic tinnitus is a frequent condition that can affect the quality of life. So far, no causal cure for tinnitus has been documented, and most pharmacologic and psychosomatic treatment modalities aim to diminish tinnitus' impact on the quality of life. Neuromodulation, a novel therapeutic modality, which aims at alternating nerve activity through a targeted delivery of a stimulus, has emerged as a potential option in tinnitus treatment...
March 12, 2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29740054/novel-bifunctional-cap-for-simultaneous-electroencephalography-and-transcranial-electrical-stimulation
#5
Sophia Wunder, Alexander Hunold, Patrique Fiedler, Falk Schlegelmilch, Klaus Schellhorn, Jens Haueisen
Neuromodulation induced by transcranial electric stimulation (TES) exhibited promising potential for clinical practice. However, the underlying mechanisms remain subject of research. The combination of TES and electroencephalography (EEG) offers great potential for investigating these mechanisms and brain function in general, especially when performed simultaneously. In conventional applications, the combination of EEG and TES suffers from limitations on the electrode level (gel for electrode-skin interface) and the usability level (preparation time, reproducibility of positioning)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734883/is-transcranial-direct-current-stimulation-an-effective-modality-in-reducing-food-craving-a-systematic-review-and-meta-analysis
#6
Seyed-Ali Mostafavi, Ali Khaleghi, Mohammad Reza Mohammadi, Shahin Akhondzadeh
Non-invasive electrical stimulation of the brain has recently been extensively investigated to regulate food craving. However, the existing literature is controversial and there are some important questions which need to be addressed about clinical and technical factors contributing to efficacy of this method. A systematic search was performed in reliable scientific databases, and 15 eligible studies were identified. The pooled standardized mean differences for the effects of transcranial direct current stimulation (tDCS) on Visual Analogue Scale, energy intake and food craving questionnaire were -0...
May 7, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29712947/resting-state-fmri-study-of-brain-activation-using-low-intensity-repetitive-transcranial-magnetic-stimulation-in-rats
#7
Bhedita J Seewoo, Kirk W Feindel, Sarah J Etherington, Jennifer Rodger
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI) to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Using anaesthetised Sprague-Dawley rats, rs-fMRI data were acquired before and after control or LI-rTMS at 1 Hz, 10 Hz, continuous theta burst stimulation (cTBS) or biomimetic high-frequency stimulation (BHFS)...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29706876/changing-brain-networks-through-non-invasive-neuromodulation
#8
REVIEW
Wing Ting To, Dirk De Ridder, John Hart, Sven Vanneste
Background/Objective : Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their potential as treatments for neurological and psychiatric disorders. Despite widespread dissemination of these techniques, the underlying therapeutic mechanisms and the ideal stimulation site for a given disorder remain unknown. Increasing evidence support the possibility of non-invasive neuromodulation affecting a brain network rather than just the local stimulation target...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29701157/pharmacological-treatment-of-body-dysmorphic-disorder
#9
Kevin Hong, Vera Nezgovorova, Genoveva Uzunova, Danya Schlussel, Eric Hollander
Body dysmorphic disorder is a challenging disorder that manifests as erroneously perceived flaws in one's physical appearance and repetitive behaviors in response to appearance concerns. This disorder is also frequently comorbid with other psychiatric disorders, including major depressive disorder and autism spectrum disorder. It is currently understood to arise from a combination of biological, psychological, and environmental factors. Treatment of body dysmorphic disorder typically consists of a combination of pharmacotherapy and cognitive behavioral therapy...
April 26, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29695150/modulation-of-electrophysiology-by-transcranial-direct-current-stimulation-in-psychiatric-disorders-a-systematic-review
#10
Minah Kim, Yoo Bin Kwak, Tae Young Lee, Jun Soo Kwon
Objective: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique increasingly used to relieve symptoms of psychiatric disorders. Electrophysiologic markers, such as electroencephalography (EEG) and event-related potentials (ERP), have high temporal resolution sensitive to detect plastic changes of the brain associated with symptomatic improvement following tDCS application. Methods: We performed systematic review to identify electrophysiological markers that reflect tDCS effects on plastic brain changes in psychiatric disorders...
April 27, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29667598/a-random-phased-array-for-mr-guided-transcranial-ultrasound-neuromodulation-in-non-human-primates
#11
Vandiver Chaplin, Marshal A Phipps, Charles F Caskey
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29651240/cognitive-neuroscience-of-attention-deficit-hyperactivity-disorder-adhd-and-its-clinical-translation
#12
REVIEW
Katya Rubia
This review focuses on the cognitive neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) based on functional magnetic resonance imaging (fMRI) studies and on recent clinically relevant applications such as fMRI-based diagnostic classification or neuromodulation therapies targeting fMRI deficits with neurofeedback (NF) or brain stimulation. Meta-analyses of fMRI studies of executive functions (EFs) show that ADHD patients have cognitive-domain dissociated complex multisystem impairments in several right and left hemispheric dorsal, ventral and medial fronto-cingulo-striato-thalamic and fronto-parieto-cerebellar networks that mediate cognitive control, attention, timing and working memory (WM)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29629499/reduced-brain-entropy-by-repetitive-transcranial-magnetic-stimulation-on-the-left-dorsolateral-prefrontal-cortex-in-healthy-young-adults
#13
Donghui Song, Da Chang, Jian Zhang, Wei Peng, Yuanqi Shang, Xin Gao, Ze Wang
Entropy indicates system irregularity and the capacity for information processing. Recent research has identified interesting voxel-wise entropy distribution patterns in normal brain and its changes due to aging and brain disorders. A question of great scientific and clinical importance is whether brain entropy (BEN) can be modulated using non-invasive neuromodulations. The purpose of this study was to address this open question using high-frequency repetitive transcranial magnetic stimulation (rTMS). BEN was calculated from resting state fMRI at each voxel acquired before and after applying 20 Hz rTMS or SHAM (control) stimulation...
April 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29628873/combined-rtms-fmri-studies-an-overlooked-resource-in-animal-models
#14
REVIEW
Bhedita J Seewoo, Sarah J Etherington, Kirk W Feindel, Jennifer Rodger
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique, which has brain network-level effects in healthy individuals and is also used to treat many neurological and psychiatric conditions in which brain connectivity is believed to be abnormal. Despite the fact that rTMS is being used in a clinical setting and animal studies are increasingly identifying potential cellular and molecular mechanisms, little is known about how these mechanisms relate to clinical changes. This knowledge gap is amplified by non-overlapping approaches used in preclinical and clinical rTMS studies: preclinical studies are mostly invasive, using cellular and molecular approaches, while clinical studies are non-invasive, including functional magnetic resonance imaging (fMRI), TMS electroencephalography (EEG), positron emission tomography (PET), and behavioral measures...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29605579/noninvasive-stimulation-of-the-ventromedial-prefrontal-cortex-modulates-emotional-face-processing
#15
Constantin Winker, Maimu A Rehbein, Dean Sabatinelli, Mira Dohn, Julius Maitzen, Carsten H Wolters, Volker Arolt, Markus Junghofer
The ventromedial prefrontal cortex (vmPFC) is associated with emotional states that can be characterized as positive affect. Moreover, a variety of psychiatric disorders that are associated with disturbed reactions toward reward- or safety-signaling stimuli reveal functional or structural anomalies within this area. Thus, neuromodulation of this region via transcranial direct current stimulation (tDCS) offers an attractive opportunity to noninvasively influence pleasant emotional and reward processing. Recent experiments revealed hemodynamic and electrophysiological evidence for valence specific modulations of emotional scene processing after excitatory and inhibitory tDCS of the vmPFC...
March 29, 2018: NeuroImage
https://www.readbyqxmd.com/read/29602532/cross-species-neuromodulation-from-high-intensity-transcranial-electrical-stimulation
#16
Alik S Widge
Transcranial electrical stimulation (TES) is a proposed tool for noninvasively modulating human brain circuits, but its ability to affect cortical physiology remains unclear. A recent study merged TES with live animal and human cadaveric recordings to verify intracranial electrical effects, then used these findings to develop a novel neuromodulation protocol.
March 27, 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29601305/noninvasive-neuromodulation-in-migraine-and-cluster-headache
#17
Amaal Starling
PURPOSE OF REVIEW: The purpose of this narrative review is to provide an overview of the currently available noninvasive neuromodulation devices for the treatment of migraine and cluster headache. RECENT FINDINGS: Over the last decade, several noninvasive devices have undergone development and clinical trials to evaluate efficacy and safety. Based on this body of work, single-pulse transcranial magnetic stimulation, transcutaneous supraorbital neurostimulation, and noninvasive vagal nerve stimulation devices have been cleared by the United States Food and Drug Administration and are available for clinical use for the treatment of primary headache disorders...
March 29, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29600889/transcranial-direct-current-stimulation-in-the-modulation-of-neuropathic-pain-a-systematic-review
#18
Mírian Celly Medeiros Miranda David, Alexa Alves de Moraes, Maíra Lopes da Costa, Carlúcia Ithamar Fernandes Franco
Objective To investigate the neuromodulating effect of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Pain (NP). Method A systematic review of articles published in the past five years in MEDLINE, LILACS, Cochrane, Scopus, ScienceDirect, and PEDro. The search was carried out from February to May 2017 using the keywords: neuropathic pain, neuralgia, nerve pain, central pain, peripheral nerve pain, tDCS. The selected studies were full articles written in Portuguese, English, or Spanish with at least one control group, and no less than one pre- or post-intervention variable, with the exclusion of case studies or case series, animal model studies, and studies with combined therapy...
March 30, 2018: Neurological Research
https://www.readbyqxmd.com/read/29563594/using-high-amplitude-and-focused-transcranial-alternating-current-stimulation-to-entrain-physiological-tremor
#19
Ahmad Khatoun, Jolien Breukers, Sara Op de Beeck, Ioana Gabriela Nica, Jean-Marie Aerts, Laura Seynaeve, Tom Haeck, Boateng Asamoah, Myles Mc Laughlin
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that can entrain physiological tremor in healthy volunteers. We conducted two experiments to investigate the effectiveness of high-amplitude and focused tACS montages at entraining physiological tremor. Experiment 1 used saline-soaked sponge electrodes with an extra-cephalic return electrode and compared the effects of a motor (MC) and prefrontal cortex (PFC) electrode location. Average peak-amplitude was 1.925 mA...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535340/exploring-the-effects-of-anodal-and-cathodal-high-definition-transcranial-direct-current-stimulation-targeting-the-dorsal-anterior-cingulate-cortex
#20
Wing Ting To, Justin Eroh, John Hart, Sven Vanneste
The dorsal anterior cingulate cortex (dACC) has been identified as a core region affected by many disorders, representing a promising target for neuromodulation. High Definition-transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation technique that has already shown promising outcomes and has been tested to engage deeper structures. This study investigates whether it is possible to modulate dACC activity using anodal and cathodal HD-tDCS. Furthermore, it examines what effects anodal and cathodal HD-tDCS targeting dACC have on cognitive and emotional processing...
March 13, 2018: Scientific Reports
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