keyword
https://read.qxmd.com/read/38539607/clinical-potential-of-transcranial-focused-ultrasound-for-neurorehabilitation-in-pediatric-cancer-survivors
#1
REVIEW
Paul VanGilder, Justin Tanner, Kevin R Krull, Ranganatha Sitaram
Cancer survivors are at a high risk for treatment-related late effects, particularly neurocognitive impairment in the attention and executive function domains. These can be compounded in pediatric populations still undergoing neural development, which has increased interest in survivorship studies and neurorehabilitation approaches to mitigate these effects. Cognitive training regimens have shown promise as a therapeutic intervention for improving cognitive function. Therapist-guided and computerized training programs with adaptive paradigms have been successfully implemented in pediatric populations, with positive outcomes on attention and working memory...
February 27, 2024: Brain Sciences
https://read.qxmd.com/read/38539589/neuromodulation-of-eating-disorders-a-review-of-underlying-neural-network-activity-and-neuromodulatory-treatments
#2
REVIEW
Kevin Wu, Yu Tung Lo, Jonathon Cavaleri, Matthew Bergosh, Jennifer Ipe, Robert G Briggs, Kay B Jann, Stuart B Murray, Xenos L Mason, Charles Y Liu, Darrin J Lee
Eating disorders are a group of psychiatric conditions that involve pathological relationships between patients and food. The most prolific of these disorders are anorexia nervosa, bulimia nervosa, and binge eating disorder. The current standard of care involves psychotherapy, pharmacotherapy, and the management of comorbid conditions, with nutritional rehabilitation reserved for severe cases of anorexia nervosa. Unfortunately, many patients often fail to respond, leaving a concerning treatment gap between the current and requisite treatments for eating disorders...
February 22, 2024: Brain Sciences
https://read.qxmd.com/read/38538225/single-session-effects-of-prolonged-continuous-theta-burst-stimulation-targeting-two-brain-regions-on-pain-perception-in-patients-with-painful-diabetic-neuropathy-a-preliminary-study
#3
JOURNAL ARTICLE
Bhushan Thakkar, Carrie L Peterson, Edmund O Acevedo
BACKGROUND: Painful diabetic neuropathy (pDN) is the most common cause of neuropathic pain (NP) in the United States. Prolonged continuous theta burst stimulation (pcTBS), a form of repetitive transcranial magnetic stimulation (rTMS), is quick (1-4 minutes) and tolerable for most individuals, compared to high frequency rTMS and can modulate pain thresholds in healthy participants. However, its effects on patients with chronic pain are still unclear. The primary purpose of this preliminary study is to investigate the effects of single session pcTBS targeted at the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) on a set of self-report measures of pain (SRMP) that assess the (a) sensory-discriminative; (b) affective-motivational; and (c) cognitive-evaluative aspects of pain experience...
March 7, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38537689/transcranial-focused-ultrasound-stimulation-in-the-infralimbic-cortex-facilitates-extinction-of-conditioned-fear-in-rats
#4
JOURNAL ARTICLE
Jaeyong Lee, Ye Eun Kim, Jihong Lim, Yehhyun Jo, Hyunjoo Jenny Lee, Yong Sang Jo, June-Seek Choi
Transcranial focused ultrasound (tFUS) neuromodulation emerges as a promising non-invasive approach for improving neurological conditions. Extinction of conditioned fear has served as a prime model for exposure-based therapies for anxiety disorders. We investigated whether tFUS stimulation to a critical brain area, the infralimbic subdivision of the prefrontal cortex (IL), could facilitate fear extinction using rats. In a series of experiments, tFUS was delivered to the IL of a freely-moving rat and compared to sham stimulation (tFUS vs...
March 25, 2024: Brain Stimulation
https://read.qxmd.com/read/38536752/causal-functional-maps-of-brain-rhythms-in-working-memory
#5
JOURNAL ARTICLE
Miles Wischnewski, Taylor A Berger, Alexander Opitz, Ivan Alekseichuk
Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation of specific functional anatomical nodes. Such experiments became available in healthy humans with the advance of transcranial alternating current stimulation (tACS)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38534532/electric-field-characteristics-of-rotating-permanent-magnet-stimulation
#6
JOURNAL ARTICLE
Pei L Robins, Sergey N Makaroff, Michael Dib, Sarah H Lisanby, Zhi-De Deng
Neurostimulation devices that use rotating permanent magnets are being explored for their potential therapeutic benefits in patients with psychiatric and neurological disorders. This study aims to characterize the electric field (E-field) for ten configurations of rotating magnets using finite element analysis and phantom measurements. Various configurations were modeled, including single or multiple magnets, and bipolar or multipolar magnets, rotated at 10, 13.3, and 350 revolutions per second (rps). E-field strengths were also measured using a hollow sphere (r=9...
March 6, 2024: Bioengineering
https://read.qxmd.com/read/38531115/high-spatial-resolution-transcranial-focused-ultrasound-neuromodulation-using-frequency-modulated-pattern-interference-radiation-force
#7
JOURNAL ARTICLE
Young Hun Kim, Ki Chang Kang, Jeong Nyeon Kim, Kwan Kyu Park, Kamyar Firouzi, Butrus T Khuri-Yakub
Stimulating the brain in a precise location is crucial in ultrasound neuromodulation. However, improving the resolution proves a challenge owing to the characteristics of transcranial focused ultrasound. In this paper, we present a new neuromodulation system that overcomes the existing limitations based on an acoustic radiation force with a frequency-modulated waveform and standing waves. By using the frequency-modulated pattern interference radiation force (FM-PIRF), the axial spatial resolution can be reduced to a single wavelength level and the target location can be controlled in axial direction electronically...
March 16, 2024: Ultrasonics
https://read.qxmd.com/read/38528855/repetitive-transcranial-magnetic-stimulation-for-working-memory-deficits-in-schizophrenia-a-systematic-review-of-randomized-controlled-trials
#8
REVIEW
Li Li, Chaomeng Liu, Weigang Pan, Wen Wang, Wenqing Jin, Yanping Ren, Xin Ma
Working memory (WM) deficits are a significant component of neurocognitive impairment in individuals with schizophrenia (SCZ). Two previous meta-analyses, conducted on randomized controlled trials (RCTs), examined the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in addressing WM deficits in individuals diagnosed with SCZ. However, the conclusions drawn from these analyses were inconsistent. Additionally, the commonly used random effects (RE) models might underestimate statistical errors, attributing a significant portion of perceived heterogeneity between studies to variations in study quality...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38506767/effects-of-transcranial-direct-current-stimulation-on-clinical-outcomes-calcitonin-gene-related-peptide-and-pituitary-adenylate-cyclase-activating-polypeptide-38-levels-in-menstrual-migraine
#9
JOURNAL ARTICLE
Buse Rahime Hasırcı Bayır, Serkan Aksu, Haşim Gezegen, Zerrin Karaaslan, Hande Yüceer, Tuba Cerrahoğlu Şirin, Cem İsmail Küçükali, Adnan Kurt, Sacit Karamürsel, Vuslat Yılmaz, Betül Baykan
OBJECTIVES: Transcranial direct current stimulation (tDCS) has been suggested as an alternative treatment option for migraine. The present study aimed to evaluate the efficacy of tDCS on clinical outcomes in addition to calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide 38 (PACAP-38) levels in individuals with menstrual-related migraine (MRM) for the first time. MATERIALS AND METHODS: In this parallel study, 58 female patients between the ages of 18 and 45 years, including 36 with MRM and 22 with nonmenstrual migraines (nMM), were recruited...
March 19, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38506766/effects-of-transcranial-ultrasound-stimulation-on-blood-oxygen-metabolism-and-brain-rhythms-in-nitroglycerin-induced-migraine-mice
#10
JOURNAL ARTICLE
Nannan Bian, Yi Yuan, Xiaoli Li
OBJECTIVES: In this study, we aimed to investigate the regulatory mechanism of transcranial ultrasound stimulation (TUS) on nitroglycerin-induced migraine in mice. MATERIALS AND METHODS: The experiment was divided into four groups, namely, the normal saline control group (n = 9), ultrasound stimulation control group (n = 6), nitroglycerin-induced migraine group (n = 9), and ultrasound stimulation group (n = 9). The behavior, blood oxygen metabolism, and brain rhythm distribution of the four groups were analyzed...
March 18, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38505983/noninvasive-intervention-by-transcranial-ultrasound-stimulation-modulation-of-neural-circuits-and-its-clinical-perspectives
#11
JOURNAL ARTICLE
Takahiro Osada, Seiki Konishi
Low-intensity focused transcranial ultrasound stimulation (TUS) is an emerging noninvasive technique capable of stimulating both the cerebral cortex and deep brain structures with high spatial precision. This method is recognized for its potential to comprehensively perturb various brain regions, enabling the modulation of neural circuits, in a manner not achievable through conventional magnetic or electrical brain stimulation techniques. The underlying mechanisms of neuromodulation are based on a phenomenon where mechanical waves of ultrasound kinetically interact with neurons, specifically affecting neuronal membranes and mechanosensitive channels...
March 20, 2024: Psychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38504094/transcranial-static-magnetic-field-stimulation-of-the-supplementary-motor-area-decreases-corticospinal-excitability-in-the-motor-cortex-a-pilot-study
#12
JOURNAL ARTICLE
Cristina Pagge, Jaime Caballero-Insaurriaga, Antonio Oliviero, Guglielmo Foffani, Claudia Ammann
Transcranial static magnetic field stimulation (tSMS) is a non-invasive brain stimulation technique that is portable and easy to use. Long-term, home-based treatments with tSMS of the supplementary motor area (SMA) are promising for movement disorders and other brain diseases. The aim of the present work was to investigate the potential of SMA-tSMS for reducing corticospinal excitability. We completed an open pilot study in which twenty right-handed healthy subjects (8 females; age: 31.3 ± 5...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38499911/application-of-data-driven-computing-to-patient-specific-prediction-of-the-viscoelastic-response-of-human-brain-under-transcranial-ultrasound-stimulation
#13
JOURNAL ARTICLE
Hossein Salahshoor, Michael Ortiz
We present a class of model-free Data-Driven solvers that effectively enable the utilization of in situ and in vivo imaging data directly in full-scale calculations of the mechanical response of the human brain to sonic and ultrasonic stimulation, entirely bypassing the need for analytical modeling or regression of the data. The well-posedness of the approach and its convergence with respect to data are proven analytically. We demonstrate the approach, including its ability to make detailed spatially resolved patient-specific predictions of wave patterns, using public-domain MRI images, MRE data and commercially available solid-mechanics software...
March 19, 2024: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/38495601/chatgpt-and-transcranial-direct-current-stimulation-for-chronic-pain
#14
EDITORIAL
Edson Silva-Filho, Rodrigo Pegado
OBJECTIVE: We aimed to open a discussion about the integration of artificial intelligence (AI) in science and clinical practice, specifically with regard to the use of transcranial direct current stimulation (tDCS) as a technique for managing chronic pain. MAIN POINTS OF DISCUSSION: To analyze the responses generated by ChatGPT and the best literature about tDCS, we formulated three questions. The answers from ChatGPT, compared to the guidelines and Cochrane review, showed that AI can be a potential strategy to help clinicians and researchers...
2024: Innovations in Clinical Neuroscience
https://read.qxmd.com/read/38484878/deep-transcranial-magnetic-stimulation-for-adolescents-with-treatment-resistant-depression-a-preliminary-dose-finding-study-exploring-safety-and-clinical-effectiveness
#15
JOURNAL ARTICLE
Michelle Thai, Aparna U Nair, Bonnie Klimes-Dougan, Sophia Albott, Thanharat Silamongkol, Michelle Corkrum, Dawson Hill, Justin W Roemer, Charles P Lewis, Paul E Croarkin, Kelvin O Lim, Alik S Widge, Ziad Nahas, Lynn E Eberly, Kathryn R Cullen
BACKGROUND: Transcranial magnetic stimulation (TMS) is an intervention for treatment-resistant depression (TRD) that modulates neural activity. Deep TMS (dTMS) can target not only cortical but also deeper limbic structures implicated in depression. Although TMS has demonstrated safety in adolescents, dTMS has yet to be applied to adolescent TRD. OBJECTIVE/HYPOTHESIS: This pilot study evaluated the safety, tolerability and clinical effects of dTMS in adolescents with TRD...
March 12, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38482504/changes-in-pain-following-bilateral-intermittent-theta-burst-transcranial-magnetic-stimulation-for-depression-a-retrospective-chart-review
#16
JOURNAL ARTICLE
Sawmmiya Kirupaharan, Roumen Milev, Joanne Bressee, Sonya Kelso, Scott Duggan, Felicia Iftene, Tim V Salomons, Wilma Hopman, Ian Gilron
INTRODUCTION: Pain management in patients with chronic pain and comorbid depression is challenging and understudied. There is interest in intermittent theta-burst stimulation (iTBS), a new modality of repetitive transcranial magnetic stimulation (rTMS). This retrospective review describes changes in pain, anxiety and depression throughout iTBS treatment at the dorsolateral prefrontal cortex (DLPFC). METHODS: A retrospective chart review was conducted of patients who underwent their first acute series of iTBS treatments at the DLPFC for depression at a single institution between 2020 and 2023...
2024: Canadian Journal of Pain, Revue Canadienne de la Douleur
https://read.qxmd.com/read/38479346/a-meta-analysis-of-transcranial-magnetic-stimulation-in-tourette-syndrome
#17
JOURNAL ARTICLE
Elizabeth R Steuber, Joseph F McGuire
There is growing enthusiasm for the treatment of neuropsychiatric disorders using neuromodulation. While some reports claim that transcranial magnetic stimulation (TMS) can be used to treat Tourette Syndrome (TS), little research exists to support this assertion. This meta-analysis examined the efficacy of TMS to reduce tic severity in patients with TS. Additionally, it explored the effect of TMS to reduce premonitory urge severity-the primary mechanism implicated in the frontline evidence-based treatment of TS...
March 8, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38479250/anodal-tdcs-over-the-motor-cortex-improves-pain-but-not-physical-function-in-chronic-chikungunya-arthritis-randomized-controlled-trial
#18
JOURNAL ARTICLE
Antônio Felipe Lopes Cavalcante, Joanna Sacha Cunha Brito Holanda, João Octávio Sales Passos, Joyce Maria Pereira de Oliveira, Edgard Morya, Alexandre H Okano, Marom Bikson, Rodrigo Pegado
BACKGROUND: Chikungunya virus (CHIKV) is a globally prevalent pathogen, with outbreaks occurring in tropical regions. Chronic pain is the main symptom reported and is associated with decreased mobility and disability. Transcranial direct current stimulation (tDCS) is emerging as a new therapeutic tool for chronic arthralgia. OBJECTIVE: To evaluate the effectiveness of 10 consecutive sessions of anodal tDCS on pain (primary outcome) in participants with chronic CHIKV arthralgia...
March 12, 2024: Annals of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38479239/tdcs-for-parkinson-s-disease-disease-related-pain-a-randomized-trial
#19
JOURNAL ARTICLE
Yeray González-Zamorano, Francisco José Sánchez-Cuesta, Marcos Moreno-Verdú, Aida Arroyo-Ferrer, Josué Fernández-Carnero, K Ray Chaudhuri, Anna Fieldwalker, Juan Pablo Romero
OBJECTIVE: To evaluate the effects of transcranial direct current stimulation (tDCS) on Parkinson's disease (PD)-related pain. METHODS: This triple-blind randomized controlled trial included twenty-two patients (age range 38-85, 10 male) with PD-related pain. Eleven subjects received ten sessions of 20 minutes tDCS over the primary motor cortex contralateral to pain at 2 mA intensity. Eleven subjects received sham stimulation. Outcome measures included changes in the Kinǵs Parkinsońs Pain Scale (KPPS), Brief Pain Inventory (BPI), widespread mechanical hyperalgesia (WMH), temporal summation of pain (TS), and conditioned pain modulation (CPM)...
February 28, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38476353/transcranial-direct-current-stimulation-for-chronic-headaches-a-randomized-controlled-trial
#20
JOURNAL ARTICLE
Jill Angela Hervik, Karl Solbue Vika, Trine Stub
BACKGROUND AND OBJECTIVES: Chronic headaches are a frequent cause of pain and disability. The purpose of this randomized trial was to examine whether transcranial direct current stimulation (tDCS) applied to the primary motor cortex, reduces pain and increases daily function in individuals suffering from primary chronic headache. MATERIALS AND METHODS: A prospective, randomized, controlled trial, where participants and assessors were blinded, investigated the effect of active tDCS vs...
2024: Front Pain Res (Lausanne)
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