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https://www.readbyqxmd.com/read/29219025/the-effect-of-growth-hormone-on-chondral-defect-repair
#1
Natalie R Danna, Bryan G Beutel, Austin J Ramme, Thorsten Kirsch, Oran D Kennedy, Eric Strauss
Objective Focal chondral defects alter joint mechanics and cause pain and debilitation. Microfracture is a surgical technique used to treat such defects. This technique involves penetration of subchondral bone to release progenitor cells and growth factors from the marrow to promote cartilage regeneration. Often this results in fibrocartilage formation rather than structured hyaline cartilage. Some reports have suggested use of growth hormone (GH) with microfracture to augment cartilage regeneration. Our objective was to test whether intra-articular (IA) GH in conjunction with microfracture, improves cartilage repair in a rabbit chondral defect model...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29217303/castleman-disease-and-rosai-dorfman-disease
#2
REVIEW
Miguel A Piris, Elena Aguirregoicoa, Santiago Montes-Moreno, Catuxa Celeiro-Muñoz
This chapter describes the main features of two different diseases, Castleman Disease (CD) and Rosai-Dorfman Disease (RDD). Castleman disease (CD) is a clinical and histopathologically heterogeneous lymphoproliferative disorder that encompasses at least three distinct entities with some common overlapping morphological features: Hyaline Vascular CD (HVCD), Unicentric Plasma Cell CD and Multicentric CD. The most important feature of HVCD is the presence of abnormal germinal centers with hyaline-vascular transformation, sometimes showing multiple germinal centers within a single reactive lymphoid follicle, this outlining HVCD as a disorder of follicular dendritic cells...
December 2, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29217083/hyalinizing-clear-cell-carcinoma-of-salivary-gland-origin-in-the-head-and-neck-clinical-and-histopathological-analysis
#3
X-H Yang, L Liu, Y-Y Shi, Y-J Hu, Q-G Hu, P Zhang
Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm of salivary gland origin with a low-grade indolent nature. It is difficult to distinguish from other malignant salivary gland tumours. Clinical outcomes following surgery are generally reported as good. The aim of this study was to further determine the features of HCCC. This study was approved by Medical ethics review of affiliated hospital of jiangsu university. Fourteen new cases of HCCC are reported. The clinical and histopathological data of these 14 cases were analysed alongside those of 141 cases identified in a systematic review of the literature (up to 2016)...
December 4, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29210715/blistering-and-skin-fragility-due-to-imatinib-therapy-loss-of-laminin-and-collagen-iv-as-a-possible-cause-of-cutaneous-basement-membrane-instability
#4
Sebastian Mühl, Jan Ehrchen, Dieter Metze
Imatinib mesylate (Glivec; Novartis AG, Basel, Switzerland) is a tyrosine kinase inhibitor which is used in the treatment of oncologic diseases like chronic myeloid leukemia and gastrointestinal stroma tumor (GIST). Among cutaneous side effects, bullous reactions are rare. The authors describe the case of a 66-year-old woman developing blistering and skin fragility on her hands, foot, lower legs, and back after intake of imatinib for treatment of GIST. Biopsy showed vacuolar alteration at the dermoepidermal junction (DEJ) associated with a few lymphocytes and a subepidermal blister...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29208903/a-novel-bioreactor-system-for-biaxial-mechanical-loading-enhances-the-properties-of-tissue-engineered-human-cartilage
#5
Christoph Meinert, Karsten Schrobback, Dietmar W Hutmacher, Travis J Klein
The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes associated with tissue-engineered implants are still limiting their application. To improve clinical outcomes and facilitate a wider use of engineered tissues, automated bioreactor systems capable of enhancing and monitoring neotissues are required. Here, we developed an innovative system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and automated fashion...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29199205/re-evaluation-of-mib-1-immunostaining-for-diagnosing-hyalinizing-trabecular-tumour-of-the-thyroid-semi-automated-techniques-with-manual-antigen-retrieval-are-more-accurate-than-fully-automated-techniques
#6
Nami Takada, Mitsuyoshi Hirokawa, Chiho Ohbayashi, Takeshi Nishikawa, Tomoo Itoh, Naoko Imagawa, Tetsunari Oyama, Tadashi Handa, Tadashi Hasegawa, Shintaro Sugita, Akiko Murata, Akira Miyauchi
Hyalinizing trabecular tumour (HTT) immunohistochemically shows cell membranous immunoreactivity for MIB-1. This aberrant immunoreactivity is an important factor for the diagnosis of HTT. However, fully automated stainers frequently fail to confirm the immunoreactivity. The aim of this study is to investigate the cause of false negative cell membranous immunoreactivity for MIB-1 in HTT using fully automated stainers, to determine potential reasons for the problem, and to establish methods confirming cell membranous immunoreactivity for MIB-1 in HTT...
December 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29198426/luliconazole-a-new-antifungal-against-candida-species-isolated-from-different-sources
#7
S Taghipour, N Kiasat, S Shafiei, M Halvaeezadeh, A Rezaei-Matehkolaei, A Zarei Mahmoudabadi
OBJECTIVE: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials...
November 29, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29193950/-unicentric-castleman-s-disease-in-cervical-back-space-neck
#8
Jenny Chamorro-Oscullo, Fernando Robles-Ramírez, Jorge Valenzuela-Tamariz, Julián Antonio Sánchez-Cortázar, Guadalupe Gómez-Pérez
BACKGROUND: Castleman´s disease is a rare, benign condition of lymphoid tissue. There are two clinical types: unicentric and multicentric with three histological variants, hyaline-vascular, plasma celular and mixed. The most common sites of this are mediastinum, adbomen and neck. Magnetic resonance imaging is well suited to depict the characteristics of the masses and their relationship to adjacent structures. The knowledge of this disease and its inclusión in the differential diagnosis from other neck masses will contribute to the therapeutic approach...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29191631/-clinical-problems-in-medical-mycology-problem-number-52
#9
Fernando Messina, Roxana Depardo, Ricardo Negroni, Mercedes Romero, Laura Walker, Alicia Arechavala, Emmanuel Marín, Cristina Canteros, Gabriela Santiso
The case of a 60 year old woman with hemoptysis and a thin-walled cavitary lesion at the upper lobe of the right lung is presented. The woman presented at the Mycology Unit of the Muñiz Hospital in Buenos Aires City 3 months after the beginning of her clinical manifestations. A hyaline micelial fungus with chlamido-arthroconidias was isolated from the bronchoalveolar lavage. Immunodiffusion and counter-immnunoelectrophoresis with coccidioidin and histoplasmin rendered positive results against both antigents, and skin tests with coccidioidin and histoplasmin were also positive with strong reactions...
November 27, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29188618/-identification-of-novel-compound-heterozygous-mutations-in-the-antxr2-gene-in-a-chinese-patient-with-juvenile-hyaline-fibromatosis
#10
Yongling Zhang, Ru Li, Yan Li, Can Liao
OBJECTIVE: To identify pathogenic mutations of ANTXR2 gene in a patient with juvenile hyaline fibromatosis. METHODS: Genomic DNA was extracted from peripheral venous blood sample from the patient. All coding exons (exons 1-17) and splicing sites of the ANTXR2 gene were amplified with PCR. Potential mutations were detected with direct sequencing of the PCR products. 100 unrelated healthy subjects were used as the controls. CLUSTALX (1.81) was employed to analyze cross-species conservation of the mutant amino acid...
December 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29188215/astroblastoma-in-a-young-female-patient-a-case-report-and-literature-review-of-clinicopathological-radiological-and-prognostic-characteristics-and-current-treatment-strategies
#11
Muhammad Sadiq, Iftikhar Ahmad, Jamila Shuja, Zubair Ahmad, Riyasat Ahmed, Khushnaseeb Ahmad
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm2) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i...
October 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29186257/lymphangioma-secondary-to-irradiation-after-mastectomy
#12
Aline Oliveti, Tatiana Basso Biasi, Gabriella Di Giunta Funchal
Lymphangioma is a rare benign disease of the lymphatic vessels. Typically, they are primary conditions but may be acquired secondarily, such as those caused by irradiation during radiotherapy for the treatment of breast cancer. The local lymphatic obstruction provoked by irradiation causes the appearance of asymptomatic hyaline vesicles on the irradiated skin. The present report describes a 78-year-old female patient, who initially presented hyaline vesicles that progressed into multiple papules with serous exudation of a yellowish and odorless secretion on the area of chronic radiodermitis in right breast...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29181103/myxoid-liposarcoma-with-cartilaginous-differentiation-showing-ddit3-rearrangement
#13
Kayo Suzuki, Taketoshi Yasuda, Kenta Watanabe, Takeshi Hori, Masahiko Kanamori, Tomoatsu Kimura
Myxoid liposarcoma (MLPS) is the second most common histologic subtype of liposarcoma. However, cartilaginous differentiation within MLPS is an extremely rare phenomenon, with only 7 cases of MLPS with cartilaginous differentiation reported to date. The majority of MLPS cases show the t(12;16)(q13;p11) translocation, resulting in the fused in sarcoma-DNA damage-inducible transcript 3 (FUS-DDIT3) fusion gene. This fusion gene as a hallmark of MLPS is very useful for differential diagnosis from other soft tissue sarcomas, and the associated protein, FUS-DDIT3, performs an important role in the phenotypic selection of targeted multipotent mesenchymal cells during oncogenesis...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29175373/non-invasive-t1%C3%AF-mapping-of-the-human-cartilage-response-to-loading-and-unloading
#14
Sven Nebelung, Björn Sondern, Holger Jahr, Markus Tingart, Matthias Knobe, Johannes Thüring, Christiane Kuhl, Daniel Truhn
OBJECTIVE: To define the physiological response to sequential loading and unloading in histologically intact human articular cartilage using serial T1ρ mapping, as T1ρ is considered to indicate the tissue's macromolecular content. METHOD: 18 macroscopically intact cartilage-bone samples were obtained from the central lateral femoral condyles of 18 patients undergoing total knee replacement. Serial T1ρ mapping was performed on a clinical 3.0-T MRI system using a modified prostate coil...
November 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29170849/myh7-mutation-associated-with-two-phenotypes-of-myopathy
#15
Nan Li, Zhe Zhao, Hongrui Shen, Qi Bing, Xuan Guo, Jing Hu
The mutations of MYH7 (slow skeletal/β-cardiac myosin heavy chain) are commonly found in familial hypertrophic/dilated cardiomyopathy, and also can cause Laing early-onset distal myopathy (LDM), myosin storage myopathy (MSM), and congenital myopathy with fiber-type disproportion (CFTD). Here we report two cases whose diagnosis was hereditary myopathy according to clinical feature and muscle pathology analysis. High-throughput genomic sequencing (next generation sequencing) was performed to validate the diagnosis...
November 24, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29169276/iatrogenic-kaposi-s-sarcoma-in-an-hiv-negative-young-male-with-crohn-s-disease-and-iga-nephropathy-a-case-report-and-brief-review-of-the-literature
#16
Annika L Windon, Stuti G Shroff
BACKGROUND: Kaposi's sarcoma (KS) is a vascular tumor arising in association with human herpesvirus-8 (HHV-8) infection, and different variants show different clinical presentations. Isolated intestinal KS in the background of Crohn's disease (CD) is exceedingly rare with only 3 cases reported in the English literature (from 1966 to 2016). CASE PRESENTATION: Herein, we report a case of intestinal KS in a 21-year-old HIV-negative Ethiopian male with a long-standing history of steroid therapy for his underlying IgA nephropathy...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29169232/microcystic-stromal-tumor-of-testicle-first-case-report-and-literature-review
#17
Pengcheng Zhu, Yaqi Duan, Qilin Ao, Guoping Wang
Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear) and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary...
November 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29166409/post-weaning-high-fat-diet-results-in-growth-cartilage-lesions-in-young-male-rats
#18
Samuel S Haysom, Mark H Vickers, Lennex H Yu, Clare M Reynolds, Elwyn C Firth, Sue R McGlashan
To determine if a high-fat diet (HF) from weaning would result in a pro-inflammatory state and affect joint cartilage, we fed male rats either HF or Chow diet post-weaning, and voluntary wheel exercise (EX) or cage only activity (SED) after 9 weeks of age. At 17 weeks body composition, plasma biomarkers and histomorphology scores of femoro-tibial cartilages of HF-SED, HF-EX, Chow-SED and Chow-EX groups were compared. Food intake and activity were not significantly different between groups. HF diet resulted in significantly higher weight gain, %fat, fat:lean ratio, and plasma leptin, insulin and TNFα concentrations, with significant interactions between diet and exercise...
2017: PloS One
https://www.readbyqxmd.com/read/29163221/the-superficial-dermis-may-initiate-keloid-formation-histological-analysis-of-the-keloid-dermis-at-different-depths
#19
Hu Jiao, Tiran Zhang, Jincai Fan, Ran Xiao
Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Samples were studied by light microscopy using routine hematoxylin and eosin histochemical staining, and immunohistochemistry to detect CD20-positive B-lymphocytes and CD3-positive T-lymphocytes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162344/disentangling-the-prognostic-heterogeneity-of-stage-iii-colorectal-cancer-through-histologic-stromal-categorization
#20
Hideki Ueno, Shigeki Sekine, Taihei Oshiro, Yukihide Kanemitsu, Tetsuya Hamaguchi, Dai Shida, Atsuo Takashima, Megumi Ishiguro, Eisaku Ito, Yojiro Hashiguchi, Fukuo Kondo, Hideyuki Shimazaki, Satsuki Mochizuki, Yoshiki Kajiwara, Eiji Shinto, Junji Yamamoto, Yasuhiro Shimada
BACKGROUND: Growing evidence suggests the importance of stroma in determining cancer biology and recent studies have identified that genes closely associated with poor prognosis subtypes of colorectal cancer are expressed by the stroma rather than epithelial cancer cells. We aimed to clarify the prognostic value of the novel histologic classification of desmoplastic reaction in stage III colorectal cancer. METHODS: A pathologic review was conducted for 466 stage III colorectal cancer patients in a single Japanese institution (1999-2006)...
November 18, 2017: Surgery
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