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https://www.readbyqxmd.com/read/28108405/defects-of-the-vertebral-endplate-implications-for-disc-degeneration-depend-on-size
#1
Uruj Zehra, Luke Flower, Katharine Robson-Brown, Michael A Adams, Patricia Dolan
BACKGROUND CONTEXT: Bony vertebral endplates must be porous to allow metabolite transport into the disc, and yet strong to resist high intradiscal pressure. Endplate defects may therefore have nutritional and mechanical consequences for the disc, depending on their size and type. We hypothesise that broad, diffuse defects are more closely associated with disc decompression and degeneration than are focal Schmorl's node-type defects. PURPOSE: To determine how the size and type of endplate defects are related to decompression and degeneration in the adjacent intervertebral disc...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28107758/retroperitoneal-unicentric-castleman-s-disease-a-case-report
#2
Nihed Abdessayed, Ahlem Bdioui, Houssem Ammar, Rahul Gupta, Nozha Mhamdi, Marwa Guerfela, Moncef Mokni
INTRODUCTION: Castleman's disease (CD) is an angio-follicular lymph node hyperplasia presenting as a localized or a systemic disease masquerading malignancy. The most common sites of CD are mediastinum, neck, axilla and pelvis. Unicentric CD in the peripancreatic region is very rare. PRESENTATION OF CASE: We report a case of the 34-year-old lady presenting with epigastric pain for 3 months. Abdominal imaging revealed a retroperitoneal mass arising from the pancreas suspected to be neuroendocrine tumor...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28105760/aerosol-based-airway-epithelial-cell-delivery-improves-airway-regeneration-and-repair
#3
E Kardia, E S Ch'ng, B H Yahaya
Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. 24 hours following injury, exogenous rabbit AECs were labelled with BrdU and aerosolized using the MicroSprayer® Aerosolizer into the injured airway. Histopathological assessments of the injury in the trachea and lungs were quantitatively scored (1 and 5 d after cell delivery)...
January 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28105129/acute-fibrinous-and-organizing-pneumonia-a-case-report-and-literature-review
#4
Xiao-Yong Xu, Fei Chen, Chen Chen, Hui-Ming Sun, Bei-Lei Zhao
Acute fibrinous and organizing pneumonia (AFOP) is a rare lung disease with distinct histological characteristics that include the diffuse presence of intra-alveolar fibrin, and the absence of eosinophils and hyaline membrane. In the present study, a case of AFOP that was diagnosed by lung biopsy is described. The patient presented with high fever and a cough with expectoration. Computed tomography of the lung showed the presence of bilateral patchy infiltrates, predominantly in the lower lobes. Histopathological examination of lung biopsy from the lower pulmonary lobe confirmed the pathological diagnosis...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28103910/epithelioid-schwannoma-of-the-skin-displaying-unique-histopathological-features-a-teaching-case-giving-rise-to-diagnostic-difficulties-on-a-morphological-examination-of-a-resected-specimen-with-a-brief-literature-review
#5
Sohsuke Yamada, Mari Kirishima, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka, Akihide Tanimoto
BACKGROUND: Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicopathological characteristics of epithelioid schwannoma. CASE PRESENTATION: A 65-year-old female presented with a history of a flat and slightly elevated firm and tan plaque accompanied by occasional tenderness, measuring 10 × 8 mm, in the right joint of her hand 1 year before resection...
January 19, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28103792/diagnosis-implications-of-the-whole-genome-sequencing-in-a-large-lebanese-family-with-hyaline-fibromatosis-syndrome
#6
Zahraa Haidar, Ramzi Temanni, Eliane Chouery, Puthen Jitesh, Wei Liu, Rashid Al-Ali, Ena Wang, Francesco M Marincola, Nadine Jalkh, Soha Haddad, Wassim Haidar, Lotfi Chouchane, André Mégarbané
BACKGROUND: Hyaline fibromatosis syndrome (HFS) is a recently introduced alternative term for two disorders that were previously known as juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH). These two variants are secondary to mutations in the anthrax toxin receptor 2 gene (ANTXR2) located on chromosome 4q21. The main clinical features of both entities include papular and/or nodular skin lesions, gingival hyperplasia, joint contractures and osteolytic bone lesions that appear in the first few years of life, and the syndrome typically progresses with the appearance of new lesions...
January 19, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28101206/primary-chondrosarcoma-of-the-thyroid-cartilage-surgery-based-management-of-a-rare-case
#7
Guo-Hua Sun, Yuan-Jin Wang, Li-Li Gao, Ning Qu, Xiang-Ming Mu, Rong-Liang Shi, Qing-Hai Ji
In this study, we present a case of a 52-year-old male with a chondrosarcoma of the left lamina of the thyroid cartilage. Pre-operative evaluations detected typical calcifications and delineated the extent of the tumor. The patient underwent a total laryngectomy to ensure the complete resection of the tumor. The tumor was histopathologically found to consist of chondrocytes in a hyaline cartilage matrix. The patient's post-operative course has been successful apart from the permanent tracheostomy. Herien, we discuss the methods and rationales for the diagnosis and management of and recovery from this rare tumor, and also provide a review of the literature...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28097114/bilateral-idiopathic-chondrolysis-of-the-hip-in-an-adult-a-case-report-and-review-of-the-literature
#8
Kyoung-Ho Moon, Eun-Ho Shin, Joon-Soon Kang
Idiopathic chondrolysis of the hip usually develops in adolescents and is a disease characterized by gradual degenerative changes of the hyaline cartilage surrounding the head of the femur. It eventually decreases the hip joint space and causes limitations in the hip joint range of motion due to pain. The authors had experienced an unusual case of bilateral idiopathic chondrolysis of the hip in an 54 year-old male; thus, we report the treatment results and literature reviews in this case report.
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28093371/sonographically-guided-knee-meniscus-injections-feasibility-techniques-and-validation
#9
Michael R Baria, Jacob L Sellon, Dan Lueders, Jay Smith
BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although prior research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described. OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28077318/alcohol-microbiome-life-style-influence-alcohol-and-non-alcoholic-organ-damage
#10
REVIEW
Manuela G Neuman, Samuel W French, Samir Zakhari, Stefen Malnick, Helmut K Seitz, Lawrence B Cohen, Mikko Salaspuro, Andreea Voinea Griffin, Andrei Barasch, Irina A Kirpich, Paul G Thomes, Laura W Schrum, Terrence M Donohue, Kusum Kharbanda, Marcus Cruz, Mihai Opris
This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, onJune 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non-alcohol-induced liver disease (NAFLD) and possible repair. We revealedthe basic aspects of alcohol metabolism that may be responsible for the development of liver diseaseas well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28073305/human-amniotic-mesenchymal-stromal-cells-as-favourable-source-for-cartilage-repair
#11
Emma Muinos-López, Tamara Hermida-Gómez, Isaac Fuentes-Boquete, Francisco Javier de Toro-Santos, Francisco J Blanco, Silvia María Díaz-Prado
INTRODUCTION: Localized trauma-derived breakdown of the hyaline articular cartilage may progress towards osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint function. Tissue engineering technologies encompass several promising approaches with high therapeutic potential for the treatment of these focal defects. However, most of the research in tissue engineering is focused on potential materials and structural cues, while little attention is directed to the most appropriate source of cells endowing these materials...
January 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28072961/-a-case-report-of-childhood-farber-s-disease-and-literature-review
#12
X H Bao, J M Tian, T Y Ji, X Z Chang
Objective: To explore the clinical features, diagnosis, treatment and the prognosis of Farber disease by case report and literature review. Method: The clinical information of a case with farber's disease diagnosed in October 2015 at Peking University First Hospital was collected and analyzed, including clinical manifestation, electrophysiology, magnetic resonance imaging, pathology, treatments and prognosis.ASAH1 gene mutational analysis was conducted in the patient and her parents.By using "Farber's disease, ASAH1" as keywords, literature was searched from Pubmed, CHKD and HGMD database from January 1951 to January 2016...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28065381/the-contribution-of-3d-quantitative-meniscal-and-cartilage-measures-to-variation-in-normal-radiographic-joint-space-width-data-from-the-osteoarthritis-initiative-healthy-reference-cohort
#13
Melanie Roth, Wolfgang Wirth, Katja Emmanuel, Adam G Culvenor, Felix Eckstein
OBJECTIVE: To explore to what extent three-dimensional measures of the meniscus and femorotibial cartilage explain the variation in medial and lateral femorotibial radiographic joint space width (JSW), in healthy men and women. METHODS: The right knees of 87 Osteoarthritis Initiative healthy reference participants (no symptoms, radiographic signs or risk factors of osteoarthritis; 37 men, 50 women; age 55.0±7.6; BMI 24.4±3.1) were assessed. Quantitative measures of subregional femorotibial cartilage thickness and meniscal position and morphology were computed from segmented magnetic resonance images...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28059097/fibrous-hamartoma-of-infancy-a-clinicopathologic-study-of-145-cases-including-2-with-sarcomatous-features
#14
Alyaa Al-Ibraheemi, Anthony Martinez, Sharon W Weiss, Harry P Kozakewich, Antonio R Perez-Atayde, Henry Tran, David M Parham, William R Sukov, Karen J Fritchie, Andrew L Folpe
Fibrous hamartoma of infancy is a rare soft tissue lesion of infants and young children with characteristic triphasic morphology, which typically occurs in the axilla and less commonly in other locations. We reviewed 145 cases of fibrous hamartoma of infancy from our consultation archives. Cases occurred in 106 males and 39 females (mean age-15 months; range-birth to 14 years), and involved both typical sites (eg, axilla/back/upper arm) (n=69) and unusual locations (n=76). Six were congenital. The tumors presented as subcutaneous masses and ranged from 0...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28058166/imaging-methods-in-the-diagnosis-of-optic-disc-drusen
#15
REVIEW
Betül Tuğcu, Hakan Özdemir
Optic disc drusen (ODD) are benign congenital anomalies of the optic nerve characterized by calcified hyaline bodies. While superficial drusen can be diagnosed easily during fundus examination, detecting buried drusen requires the use of additional imaging methods such as B-scan ultrasonography (USG), fundus fluorescein angiography (FFA), computed tomography (CT) and fundus autofluorescence (FAF). ODD can be detected by USG with the presentation of highly reflective round structures. ODD appear as hyperautofluorescent areas on FAF and bright spots on CT scans...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057712/embolization-of-blood-supply-artery-followed-by-surgery-for-treatment-of-mesorectal-castleman-s-disease-case-report-and-literature-review
#16
Guanyu Yu, Fuao Cao, Haifeng Gong, Peng Liu, Ge Sun, Wei Zhang
A 23-year-old male patient was diagnosed as having a hypervascular pelvic mass by ultrasonography and magnetic resonance examination. A pathology puncture showed vitreous vascular Castleman's disease. Because of concerns about tumor blood supply, embolization under digital subtraction angiography (DSA) was performed on the artery of the pelvic tumor before resection of the mass and surrounding rectum. Castleman's disease of pelvic lymph node (mixed type, mainly hyaline vascular type) was confirmed pathologically from postoperative biopsy...
January 5, 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28044425/immediate-effects-of-diamond-burr-debridement-in-patients-with-spontaneous-chronic-corneal-epithelial-defects-light-and-electron-microscopic-evaluation
#17
Charlotte Dawson, Carolina Naranjo, Belen Sanchez-Maldonado, Georgina V Fricker, Rose N Linn-Pearl, Natalia Escanilla, Christiane Kafarnik, David J Gould, Rick F Sanchez, Marian Matas-Riera
PURPOSE: To evaluate immediate effects of diamond burr debridement (DBD) on the cornea of canine patients diagnosed with spontaneous chronic corneal epithelial defects (SCCEDs). ANIMALS STUDIED: Eight client owned dogs with SCCEDs. METHODS: Nine eyes from eight dogs with SCCEDs underwent superficial keratectomy (SK). The ulcerated area was divided into quadrants with a 300-micron restricted depth knife. Two of four quadrants underwent DBD for 40-60 s...
January 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28042220/internal-carotid-artery-fibromuscular-dysplasia-in-a-child-incidental-postmortem-finding-after-head-injury
#18
Arulselvi Subramanian, Garima Aggarwal, Deepak Agarwal, Sanjeev Lalwani
Fibromuscular dysplasia (FMD) is a rare, segmental, nonatheromatous, and noninflammatory arterial disease of unknown etiology. It predominantly involves renal artery (60-75%) followed by extracranial part of the internal carotid artery and vertebral arteries (25-30%). The disease typically affects middle-aged women and involves intermediate-sized arteries throughout the body. There are rare case reports of extracranial FMD compounding a trauma case. A patient was brought to trauma center emergency with a history of fall from height...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28028431/oncocytic-pleomorphic-adenoma-of-palatal-salivary-gland-with-macrophages-and-giant-cells-associated-with-cholesterol-crystals
#19
Gargi S Sarode, Sachin C Sarode, Shankargouda Patil, Sukumaran Anil
Pleomorphic adenoma (PA) is the most common salivary gland tumor characterized by histo-morphological diversity in the form of myxoid, hyalinized, chondroid, osseous, and squamous areas. In this paper, we report a rare case of predominantly oncocytic variant of PA in a 45-year-old male patient on the posterior palatal region. Microscopic examination showed homogenous eosinophilic cellular mass composed of epithelial components arranged in the form of tubular and solid patterns. The polygonal and oval cells showed abundant dark eosinophilic granular cytoplasm...
October 24, 2016: Clinics and Practice
https://www.readbyqxmd.com/read/28026050/case-of-late-onset-erythropoietic-protoporphyria-with-myelodysplastic-syndrome-who-has-homozygous-ivs3-48c-polymorphism-in-the-ferrochelatase-gene
#20
Hiromi Suzuki, Katsuko Kikuchi, Noriko Fukuhara, Hajime Nakano, Setsuya Aiba
We report the case of a 42-year-old man with a 5-year history of myelodysplastic syndrome and photosensitivity who had developed painful erythema and blisters on sun-exposed sites. Histological examination of a mildly lichenified lesion on the dorsal finger revealed extensive deposits of a hyaline-like, periodic acid-Schiff-positive material around superficial dermal blood vessels. Laboratory tests showed elevated erythrocyte protoporphyrin and normal urinary porphyrins, suggesting a diagnosis of erythropoietic protoporphyria...
December 27, 2016: Journal of Dermatology
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