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https://www.readbyqxmd.com/read/28634622/burned-out-seminoma-revealed-by-solitary-rib-bone-metastasis
#1
Toshihiko Nishisho, Mika Sakaki, Ryo Miyagi, Shoichiro Takao, Koichi Sairyo
Burned-out tumor is a rare phenomenon in which a testicular tumor regresses in the primary lesion and progresses in a metastatic lesion. We report the case of a 30-year-old male with burned-out seminoma revealed by open biopsy of solitary 10th rib bone metastasis. He underwent inguinal orchiectomy, which revealed hyalinization, indicating a spontaneously regressed testicular tumor. Chemotherapy for seminoma was administered in three cycles of bleomycin + etoposide + cisplatin therapy. The chemotherapy was effective, and wide resection of the rib was subsequently performed...
June 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28633793/treatment-of-a-focal-articular-cartilage-defect-of-the-talus-with-polymer-based-autologous-chondrocyte-implantation-a-12-year-follow-up-period
#2
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Autologous chondrocyte implantation (ACI) is a first-line treatment option for large articular cartilage defects. Although well-established for cartilage defects in the knee, studies of the long-term outcomes of matrix-assisted ACI to treat cartilage defects in the ankle are rare. In the present report, we describe for the first time the long-term clinical and radiologic results 12 years after polymer-based matrix-assisted ACI treat a full-thickness talar cartilage defect in a 25-year-old male patient. The clinical outcome was assessed using the visual analog scale and Freiburg ankle score, magnetic resonance imaging evaluation using the Henderson-Kreuz scoring system and T2 mapping...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28632455/joint-preservation-techniques-in-orthopaedic-surgery
#3
Philip J York, Frank B Wydra, Matthew E Belton, Armando F Vidal
CONTEXT: With increasing life expectancy, there is growing demand for preservation of native articular cartilage to delay joint arthroplasties, especially in younger, active patients. Damage to the hyaline cartilage of a joint has a limited intrinsic capacity to heal. This can lead to accelerated degeneration of the joint and early-onset osteoarthritis. Treatment in the past was limited, however, and surgical treatment options continue to evolve that may allow restoration of the natural biology of the articular cartilage...
June 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28631707/-chondroprotectors-a-range-of-application-in-general-somatic-practice
#4
O A Shavlovskaya
Chondroprotectors (CP) are biological agents that contribute to the regeneration of the cartilage surfaces and articular capsule, participating in the metabolic processes of the articular cartilage. Progressive loss of hyaline cartilage and lower levels of chondroitin sulfate were observed in osteoarthritis (OA) at different sites, including dorsopathy. OA therapy is aimed at slowing disease progression, relieving pain symptoms, and reducing functional disorders. For this purpose, oral or injectable CPs (Chondroguard, Sustaguard) are prescribed...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28629625/what-exactly-regression-of-atherosclerosis-or-foreign-body-reaction-with-hyaline-arteriosclerosis-drives-transient-scaffolding-of-coronary-arteries-a-pooled-analysis-of-observational-absorb-studies-with-a-serial-multimodality-imaging-substudy-of-absorb-cohort
#5
Alexander N Kharlamov, John A Feinstein, John A Cramer, John A Boothroyd
OBJECTIVES: We aimed to estimate the trends of the artery remodeling after transient scaffolding. BACKGROUND: At least 2.62% reduction of the per cent atheroma volume (PAV) or plaque burden (PB) performed in ABSORB B trial at 60months. METHODS: The detailed multiple serial imaging evaluation was performed by intravascular ultrasound (IVUS) in comparison with quantitative coronary angiography (QCA), multislice CT (MSCT) and optical coherence tomography (OCT) thru 24months in the ABSORB cohort B1 trial (n=45) with the pooled analysis in ABSORB A and B trials (n=131)...
June 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28622746/sol-gel-derived-lithium-releasing-glass-for-cartilage-regeneration
#6
Siwei Li, Anthony Lb Maçon, Manon Jacquemin, Molly M Stevens, Julian R Jones
Wnt-signalling cascade is one of the crucial pathways involved in the development and homeostasis of cartilage. Influencing this pathway can potentially contribute to improved cartilage repair or regeneration. One key molecular regulator of the Wnt pathway is the glycogen synthase kinase-3 enzyme, the inhibition of which allows initiation of the signalling pathway. This study aims to utilise a binary SiO2-Li2O sol-gel derived glass for controlled delivery of lithium, a known glycogen synthase kinase-3 antagonist...
July 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28622182/reflux-associated-cholecystopathy-analysis-of-76-gallbladders-from-patients-with-supra-oddi-union-of-the-pancreatic-duct-and-common-bile-duct-pancreatobiliary-maljunction-elucidates-a-specific-diagnostic-pattern-of-mucosal-hyperplasia-as-a-prelude-to-carcinoma
#7
Takashi Muraki, Bahar Memis, Michelle D Reid, Takeshi Uehara, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Alexa Freedman, Shishir Maithel, Juan M Sarmiento, Alyssa Krasinskas, Jill Koshiol, Volkan Adsay
Pancreaticobiliary maljunction (PBM) is the anomalous union of the main pancreatic duct and common bile duct outside the Oddi-sphincter, allowing the reflux of pancreatic juice to the gallbladder. There is only limited awareness and understanding of the pathologic correlates of this condition, mostly from Japan; this entity is largely unrecognized in the West. In this study, 76 gallbladders from patients with PBM (64 from Japan; 12 from the United States) were analyzed and contrasted with 66 from non-PBM patients...
June 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28610122/a-new-species-of-i-otothyropsis-i-siluriformes-loricariidae-from-the-upper-r%C3%A3-o-paran%C3%A3-basin-paraguay-with-a-discussion-of-the-limits-between-i-otothyropsis-i-and-hisonotus
#8
Bárbara B Calegari, Walter Gill Morlis, Roberto E Reis
Otothyropsis dialeukos is described from Itá creek, tributary to the upper Río Paraná basin, Paraguay. The new species is distinguished from its congeners by having a unique caudal-fin coloration pattern composed of a brown to almost black background with roundish hyaline blotches in the middle of the outermost branched rays and a hyaline posterior border interrupted in middle rays; abdomen entirely covered by enlarged plates, without naked areas; longer pectoral- and dorsal-fin spines; absence of a raised crest of enlarged odontodes on the posterior portion of the parieto-supraoccipital, and other morphometric and meristic features...
March 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609342/cutaneous-collagenous-vasculopathy-report-of-two-cases-presenting-as-disseminated-telangiectasias-and-review-of-the-literature
#9
Laure Bondier, Mathilde Tardieu, Perrine Leveque, Isabelle Challende, Nicole Pinel, Marie T Leccia
Cutaneous collagenous vasculopathy is a recently described idiopathic microangiopathy characterized by acquired diffuse cutaneous telangiectasias and specific histological features: dilated capillaries in the superficial dermis, with walls thickened by hyaline material containing collagen IV by immunohistochemistry. The authors describe 2 cases and review all cases reported in the literature to date, 34 cases including our own. Cases were mainly observed in women (sex ratio 0.41), median age 63.5 (16-85). Hypertension and diabetes seem more frequent in these patients than in the general population...
June 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28606791/chondrolipoma-of-the-ankle-in-a-child-a-case-report
#10
Takuya Ishibashi, Jun Nishio, Shunsuke Kobayashi, Kei Shiramizu, Takuaki Yamamoto
Chondrolipoma is an extremely rare variant of lipoma with cartilaginous metaplasia. The presence of nonlipomatous components can lead to a variety of entities in the differential diagnosis from the radiologic findings. We describe an unusual case of a chondrolipoma occurring in the right ankle of a 9-year-old female. Physical examination showed a 3.5-cm, elastic-hard, poorly mobile, nontender mass adherent to the Achilles tendon. Plain radiographs revealed a faintly calcified soft tissue mass without bone involvement...
June 9, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28604699/cmg2-antxr2-regulates-extracellular-collagen-vi-which-accumulates-in-hyaline-fibromatosis-syndrome
#11
Jérôme Bürgi, Béatrice Kunz, Laurence Abrami, Julie Deuquet, Alessandra Piersigilli, Sabine Scholl-Bürgi, Ekkehart Lausch, Sheila Unger, Andrea Superti-Furga, Paolo Bonaldo, F Gisou van der Goot
Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Here we show that CMG2 is an important regulator of collagen VI homoeostasis. CMG2 loss of function promotes accumulation of collagen VI in patients, leading in particular to nodule formation. Similarly, collagen VI accumulates massively in uteri of Antxr2(-/-) mice, which do not display changes in collagen gene expression, and leads to progressive fibrosis and sterility...
June 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28602254/formation-and-germination-of-temporary-cysts-of-cochlodinium-polykrikoides-margalef-dinophyceae-and-their-ecological-role-in-dense-blooms
#12
Hyeon Ho Shin, Zhun Li, Yang Ho Yoon, Seok Jin Oh, Wol-Ae Lim
While the initiation and development of dense bloom of Cochlodinium polykrikoides have been shown to be related to some environmental factors, little is known about the ecological role of the formation and germination of temporary cysts, nor of their significance for the rapid expansion of dense regional-scale blooms. This study examined the factors affecting the formation and germination of temporary cysts of C. polykrikoides, and provides details about the germination process. In the laboratory experiments, C...
June 2017: Harmful Algae
https://www.readbyqxmd.com/read/28602122/transcriptome-wide-analyses-of-human-neonatal-articular-cartilage-and-human-mesenchymal-stem-cells-hmscs-derived-cartilage-provide-a-new-molecular-target-for-evaluating-engineered-cartilage
#13
Rodrigo Alfonso Somoza, Diego Correa, Ivan Labat, Hal Sternberg, Megan E Forrest, Ahmad M Khalil, Michael D West, Paul J Tesar, Arnold I Caplan
Cellular differentiation comprises a progressive, multistep program that drives cells to fabricate a tissue with specific and site distinctive structural and functional properties. Cartilage constitutes one of the potential differentiation lineages that Mesenchymal Stem Cells (MSCs) can follow under the guidance of specific bioactive agents. Single agents such as TGF-β and BMP2 in unchanging culture conditions have been historically used to induce in vitro chondrogenic differentiation of MSCs. Despite the expression of traditional chondrogenic biomarkers such as type II collagen and aggrecan, the resulting tissue represents a transient cartilage rather than an in vivo articular cartilage (AC), differing significantly in structure, chemical composition, cellular phenotypes, and mechanical properties...
June 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28600828/allogeneic-mscs-and-recycled-autologous-chondrons-mixed-in-a-one-stage-cartilage-cell-transplantion-a-first-in-man-trial-in-35-patients
#14
Tommy S de Windt, Lucienne A Vonk, Ineke C M Slaper-Cortenbach, Razmara Nizak, Mattie H P van Rijen, Daniel B F Saris
MSCs are known as multipotent mesenchymal stem cells that have been found capable of differentiating into various lineages including cartilage. However, recent studies suggest MSCs are pericytes that stimulate tissue repair through trophic signaling. Aimed at articular cartilage repair in an one-stage cell transplantation, this study provides first clinical evidence that MSCs stimulate autologous cartilage repair in the knee without engrafting in the host tissue. A phase I (first-in-man) clinical trial studied the one-stage application of allogeneic MSCs mixed with 10% or 20% recycled defect derived autologous chondrons for the treatment of cartilage defects in 35 patients...
June 10, 2017: Stem Cells
https://www.readbyqxmd.com/read/28597211/characterization-and-use-of-equine-bone-marrow-mesenchymal-stem-cells-in-equine-cartilage-engineering-study-of-their-hyaline-cartilage-forming-potential-when-cultured-under-hypoxia-within-a-biomaterial-in-the-presence-of-bmp-2-and-tgf-%C3%A3-1
#15
Thomas Branly, Lélia Bertoni, Romain Contentin, Rodolphe Rakic, Tangni Gomez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre, Sandrine Jacquet, Fabrice Audigié, Jean-Marie Denoix, Magali Demoor, Philippe Galéra
Articular cartilage presents a poor capacity for self-repair. Its structure-function are frequently disrupted or damaged upon physical trauma or osteoarthritis in humans. Similar musculoskeletal disorders also affect horses and are the leading cause of poor performance or early retirement of sport- and racehorses. To develop a therapeutic solution for horses, we tested the autologous chondrocyte implantation technique developed on human bone marrow (BM) mesenchymal stem cells (MSCs) on horse BM-MSCs. This technique involves BM-MSC chondrogenesis using a combinatory approach based on the association of 3D-culture in collagen sponges, under hypoxia in the presence of chondrogenic factors (BMP-2 + TGF-β1) and siRNA to knockdown collagen I and HtrA1...
June 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28593889/circonscript-subcutaneous-arteriovenous-malformation-of-the-head
#16
Vladimir Mirchevski, Elizabeta Zogovska, Aleksandar Chaparoski, Venko Filipce, Milenko Kostov, Mirko Mishel Mirchevski
The aim of this study is to show the various possibilities to treat this rare malformation, accentuating the results of the early surgical treatment before complications. MATERIAL: The authors present 8 cases of patients with subcutaneous arteriovenous malformations, 5 females and 3 males (age of 7, 13, 19, 23, 27, 52 and 58 years) treated in the period of 1999 until 2015 at the Clinic for Neurosurgery and the Clinic for Plastic, Aesthetic and Reconstructive Surgery in Skopje, Republic of Macedonia...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28587618/effect-of-tryptase-inhibition-on-joint-inflammation-a-pharmacological-and-lentivirus-mediated-gene-transfer-study
#17
Alexandre Denadai-Souza, Camilla Moreira Ribeiro, Corinne Rolland, Anne Thouard, Céline Deraison, Cristoforo Scavone, Daniel Gonzalez-Dunia, Nathalie Vergnolle, Maria Christina Werneck Avellar
BACKGROUND: Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis. The aim of the present study was to evaluate the impact of tryptase inhibition on experimental arthritis. METHODS: Analysis of gene expression and regulation in the mouse knee joint was performed by RT-qPCR and in situ hybridization. Arthritis was induced in male C57BL/6 mice with mBSA/IL-1β...
June 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28584844/castleman-disease-presenting-as-an-abdominal-mass
#18
Farnaz Shariati, Elizabeth Verter, Wendy Chang, Li Huang, Virendra Joshi
Unicentric Castleman disease is a rare condition of lymphoid hyperplasia, of which only 15% of cases occur in the abdomen. We report a 66-year-old man who presented with complaints of abdominal pain. Computed tomography scans revealed nephrolithiasis and a homogeneous calcified mass between the pancreas and stomach and several para-pancreatic nodes. Direct visualization during exploratory laparotomy revealed a mass on the lesser curvature of the stomach. Pyloromyotomy and mass resection were performed. Biopsy showed reactive lymphoid hyperplasia consistent with the hyaline vascular variant of Castleman disease...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28584531/intraoral-ancient-schwannoma-a-systematic-review-of-the-case-reports
#19
REVIEW
Jahanshah Salehinejad, Zahra Sahebnasagh, Shadi Saghafi, Zoha Sahebnasagh, Nafise Amiri
Intraoral ancient schwannoma is a rare type of oral schwannoma, which is encapsulated and well demarcated from the surrounding tissues. Ancient schwannomas are associated with conventional features of neurilemmoma; however, they are distinguished from other types of schwannoma due to factors such as the long history, cellular architecture showing hypocellularity, and hyalinized matrices. This systematic review was performed through searching in databases such as PubMed and Google Scholar using related keywords (intraoral, oral, ancient, schwannoma, and neurilemmoma)...
March 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28578627/coati-bodies-cytoplasmic-hyaline-globules-in-the-ganglionic-neurons-of-aging-captive-coatis
#20
Timothy K Cooper, Michael M Garner, Jennifer Baccon, Haresh Mani
Intensely eosinophilic and glassy intracytoplasmic inclusions were present in the neurons of the peripheral autonomic ganglia, Meissner's and Auerbach's plexus, and spinal ganglia in 20 aged white-nosed coatis ( Nasua narica, 7-19 years old) and in 4 of 7 brown-nosed coatis ( Nasua nasua, 2-21 years old) from multiple zoological institutions. Inclusions were single to numerous, sometimes distorting the cell. Pheochromocytomas were present in 5 of 16 white-nosed and 2 of 6 brown-nosed coatis, although no inclusions were present in the adrenal glands...
January 1, 2017: Veterinary Pathology
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