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metabolism and heart failure

Robert H Oakley, Matthew J Campen, Michael L Paffett, Xin Chen, Zhongjing Wang, Traci L Parry, Carolyn Hillhouse, John A Cidlowski, Monte S Willis
BACKGROUND: We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1-/- mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice exhibit impaired function indicative of heart failure. The present study was undertaken to understand the underlying transcriptional alterations in the RV of MuRF1-/- and MuRF1 Tg + mice. METHODS: Microarray analysis was performed on RNA isolated from the RV of MuRF1-/-, MuRF1 Tg+, and wild-type control mice exposed to CH...
September 21, 2018: BMC Medical Genetics
Sung-Ai Kim, Min-Kyung Kang, Chi Young Shim, Sak Lee, Byung-Chul Chang, Jong-Won Ha
BACKGROUND: Patients with chronic heart failure have alteration in body composition as a reduction in fat mass, lean body mass and bone mass. However, body wasting in valvular heart disease and the impact of corrective valvular surgery on body composition has not been investigated. OBJECTIVES: We hypothesized that body wasting in severe mitral valve (MV) diseases is reversible through MV surgery. METHODS: Forty eight patients who were scheduled to undergo MV surgery were consecutively enrolled after excluding patients with combined valvular heart disease, ischemic heart disease, cardiomyopathies, and diseases or who were taking medications that could affect metabolism...
2018: PloS One
Kyle H Cichos, Jessica L Churchill, Sierra G Phillips, Shawna L Watson, Gerald McGwin, Elie S Ghanem, Brent A Ponce
INTRODUCTION: Hip fractures and metabolic syndrome (MetS) are becoming major global healthcare burdens as populations age. This study sought to determine the impact of MetS in hip fracture patients on perioperative outcomes following operative fixation or arthroplasty. METHODS: Data from the 2004-2014 Nationwide Inpatient Sample was used to select 3,348,207 discharges with hip fracture. MetS patients were identified by having at least 3 of 4 component comorbidities: hypertension, dyslipidemia, obesity, and diabetes...
September 8, 2018: Injury
Mayanka Kamboj, Amir Kazory
Over the last decades, there have been major advancements in the field of renal replacement therapy (RRT) with utilization of newer technologies and advent of various modalities. Once exclusively used for treatment of renal failure and its metabolic consequences, the science of RRT has expanded to include non-renal indications such as treatment of fluid overload in patients with refractory heart failure. Hepatic encephalopathy due to sudden rise in serum ammonia level in the setting of acute liver failure represents an underexplored area in which RRT can potentially be helpful...
September 18, 2018: Blood Purification
Desiree Abdurrachim, Xing Qi Teo, Chern Chiuh Woo, Wei Xin Chan, Janise Lalic, Carolyn S P Lam, Philip Teck Hock Lee
AIMS: Sodium glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce the risk of cardiovascular events in clinical trials; yet the underlying mechanisms for cardio-protection remain poorly understood. Increased myocardial ketone body utilization has been hypothesized to contribute to improved cardiac metabolic efficiency with SGLT2i, but this has not been conclusively demonstrated. We investigated the effects of the SGLT2i empagliflozin on myocardial ketone body utilization in diabetic, obese spontaneously hypertensive heart failure (SHHF) rats, after six months of treatment...
September 17, 2018: Diabetes, Obesity & Metabolism
Xiaowen Zhang, Fei Shao, Lin Zhu, Yuyang Ze, Dalong Zhu, Yan Bi
BACKGROUND: Efficacy trials showed that glucagon-like peptide-1 receptor (GLP1R) agonists reduced metabolic risk factors in addition to glucose lowering, but the cardiovascular and microvascular efficacy of this drug class remains to be determined. We aimed to evaluate the overall cardiovascular and microvascular efficacy of GLP1R agonists by performing a meta-analysis with trial sequential analysis. METHODS: Randomized controlled, cardiovascular outcomes trials including at least 2000 patient-years' follow-up and 100 composite cardiovascular events were included...
September 17, 2018: BMC Pharmacology & Toxicology
Yael Peled, Dov Freimark, Yedael Har-Zahav, Eyal Nachum, Alexander Kogan, Yigal Kassif, Jacob Lavee
BACKGROUND: Heart transplantation (HT) is the treatment of choice for patients with end-stage heart failure. The HT unit at the Sheba Medical Center is the largest of its kind in Israel. OBJECTIVES: To evaluate the experience of HT at a single center, assess trends over 3 decades, and correlate with worldwide data. METHODS: Between 1990 and 2017, we reviewed all 285  adult HT patients. Patients were grouped by year of HT: 1990-1999 (decade 1), 2000-2009 (decade 2), and 2010-2017 (decade 3)...
September 2018: Israel Medical Association Journal: IMAJ
Karen Lindhardt Madsen, Nicolai Preisler, Jan Rasmussen, Gitte Hedermann, Jess Have Olesen, Allan Meldgaard Lund, John Vissing
Context: Primary Carnitine Deficiency (PCD) is an inborn error of fatty acid metabolism. PCD patients risk sudden heart failure upon fasting or illness if they are not treated with daily L-carnitine. Objective: To investigate energy metabolism during exercise in patients with PCD with and without L-carnitine treatment. Design: Interventional study. Setting: Hospital exercise laboratories and department of cardiology...
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
Shohei Yoshida, Shigeru Miyagawa, Satsuki Fukushima, Takuji Kawamura, Noriyuki Kashiyama, Fumiya Ohashi, Toshihiko Toyofuku, Koichi Toda, Yoshiki Sawa
In this study, we proposed that the functionality or phenotype of differentiated cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CMs) might be modified by co-culture with mesenchymal stem cells (MSCs), resulting in an improved therapeutic potential for failing myocardial tissues. Structural, motility, electrophysiological, and metabolic analyses revealed that iPSC-CMs co-cultured with MSCs displayed aligned myofibrils with A-, H-, and I-bands that could contract and relax quickly, indicating the promotion of differentiation and the establishment of the iPSC-CM structural framework, and showed clear gap junctions and an electric pacing of >2 Hz, indicating enhanced cell-cell interactions...
August 16, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Fen Gong, Junfei Gu, Haijun Wang
The prevalence of cardiomyopathy due to metabolic stress has up-regulated dramatically; nevertheless, its molecular mechanisms remain unclear. Here we suggested that transmembrane BAX inhibitor motif-containing 1 (Tmbim1) is down-regulated in the hearts of mice fed with high fat diet (HFD). We provided evidence that Tmbim1 knockout (KO) accelerated HFD-induced metabolic disorders in mice, as supported by the remarkable increase of fasting serum glucose and insulin levels. HFD-induced cardiac dysfunctions were greatly intensified by the loss of Tmbim1, along with higher levels of lactate dehydrogenase (LDH) and creatine kinase (CK) in serum...
September 11, 2018: Biochemical and Biophysical Research Communications
Aaron I Vinik, Carolina Casellini, Henri K Parson, Sheri R Colberg, Marie-Laure Nevoret
Autonomic nervous system (ANS) imbalance manifesting as cardiac autonomic neuropathy in the diabetic population is an important predictor of cardiovascular events. Symptoms and signs of ANS dysfunction, such as resting heart rate elevations, diminished blood pressure responses to standing, and altered time and frequency domain measures of heart rate variability in response to deep breathing, standing, and the Valsalva maneuver, should be elicited from all patients with diabetes and prediabetes. With the recognition of the presence of ANS imbalance or for its prevention, a rigorous regime should be implemented with lifestyle modification, physical activity, and cautious use of medications that lower blood glucose...
2018: Frontiers in Neuroscience
T Scott Bowen, Christian Herz, Natale P L Rolim, Anne-Marie Ormbostad Berre, Martin Halle, Angela Kricke, Axel Linke, Gustavo Justo da Silva, Ulrik Wisloff, Volker Adams
BACKGROUND: HFpEF is underpinned by detrimental skeletal muscle alterations that contribute to disease severity, yet underlying mechanisms and therapeutic treatments remain poorly established. This study used an animal model of HFpEF to better understand whether skeletal muscle abnormalities were: 1) fiber-type specific; and 2) reversible by various exercise training regimes. METHODS AND RESULTS: Lean controls were compared to obese ZSF1 rats at 20 weeks, and 8 weeks later following sedentary, high-intensity interval training, or moderate-continuous treadmill exercise...
September 6, 2018: Journal of Cardiac Failure
Jesús Peteiro, Alberto Bouzas-Mosquera, Javier Broullon, Jose M Larrañaga, Jose M Vazquez-Rodriguez
BACKGROUND: The role of exercise echocardiography (ExE) for the assessment of patients with dyspnea is promising. We aimed to analyze the clinical characteristics and outcome of patients with this condition referred for ExE. METHODS: A total of 505 patients (66 ± 11 years, 57% women) referred for evaluation of dyspnea were considered. Mitral regurgitation, ratio of early left ventricular inflow wave to early diastolic annulus wave (E/e'), and wall motion abnormalities (WMAs) were measured at rest and at exercise...
September 4, 2018: Journal of Cardiology
Elżbieta Kalicińska, Katarzyna Wojtas, Jacek Majda, Maciej Zacharski, Jacek Skiba, Jan Śliwowski, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska
BACKGROUND: The hormonal metabolism of adipose tissue differs across regions of fat. This issue has never been verified in male patients with coronary artery disease (CAD) with and without systolic heart failure (SHF). METHODS: We examined 90 male patients with CAD with and without SHF and 42 healthy controls. RESULTS: In patients with CAD with and without SHF, androgen receptor (AR) expression in adipose tissue of the lower leg was higher than AR expression of the thoracic wall and epicardial adipose tissue (EAT) (both p < ...
September 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Sergio F Estrada-Orihuela, Carlos Ibarra-Pérez
Lasalocid, a specific mobile membrane ionophore for calcium, dopamine and norepinephrine was assayed in its capacity to reduce or maintain unaltered the cardiovascular function in conditions of imminent myocardial injury. In experiments of coronary blockade and reperfusion carried out in rat heart, it was found that when administered from 5 to 30 minutes prior to the induction of coronary blockade, at a concentration of 2 mg/kg of body weight, the ionophore immediately, simultaneously, and completely interrupts the blood pressure decay, cardiac frequency increase, electrical ventricular tachycardia and fibrillation, as well as the fall of mitochondrial oxidative phosphorylation and decay of mitochondrial oxygen uptake provoked by the induced myocardial injury...
September 6, 2018: Molecular and Cellular Biochemistry
Li Wang, Kai Gao, Dan Wang
Objectives: Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF exercise group (Exercise-CHF group)...
August 2018: Iranian Journal of Basic Medical Sciences
Vajir Malek, Anil Bhanudas Gaikwad
Aims: LCZ696, a first-generation dual angiotensin receptor-neprilysin inhibitor (ARNi), is effective in treating heart failure patients. However, the role of ARNis in treating diabetic cardiomyopathy is poorly understood. This study evaluates the efficacy of a novel combination of telmisartan [angiotensin receptor blocker (ARB)] and thiorphan [neprilysin inhibitor (NEPi)] in ameliorating diabetic cardiomyopathy while, at the same time, exploring the relevant underlying molecular mechanism(s)...
September 4, 2018: Cardiovascular Research
Syed Saleem Mujtaba, Stephen Clark
INTRODUCTION: Carcinoid heart disease most frequently involves the tricuspid or, more rarely, the pulmonary valve and presents with right heart failure as 5-HT is metabolized by the lung. Left-sided valve involvement is quite rare. We describe our experience of 3 patients presenting with heart failure secondary to carcinoid heart disease affecting all four cardiac valves. There are only four previous isolated case reports in the literature. METHODS: All three patients underwent quadruple valve replacement during a single operation...
July 2018: Brazilian Journal of Cardiovascular Surgery
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Valeria Avataneo, Amedeo De Nicolò, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Iron-burden-induced arrhythmia and heart failure are among the leading causes of morbidity and mortality in β-thalassaemia major patients. T2* cardiac magnetic resonance remains the only reliable noninvasive method for the heart iron excess assessment. We explored the role of single nucleotide polymorphisms involved in vitamin D metabolism, transport and activity and in deferasirox (DFX) metabolism on cardiac iron burden. PATIENTS AND METHODS: One hundred and five β-thalassaemia patients, treated with DFX, were enrolled in the present study...
September 2018: Pharmacogenetics and Genomics
Magdalena Dziegala, Krystian Josiak, Monika Kasztura, Kamil Kobak, Stephan von Haehling, Waldemar Banasiak, Stefan D Anker, Piotr Ponikowski, Ewa Jankowska
Specific skeletal myopathy constitutes a common feature of heart failure, chronic obstructive pulmonary disease, and type 2 diabetes mellitus, where it can be characterized by the loss of skeletal muscle oxidative capacity. There is evidence from in vitro and animal studies that iron deficiency affects skeletal muscle functioning mainly in the context of its energetics by limiting oxidative metabolism in favour of glycolysis and by alterations in both carbohydrate and fat catabolic processing. In this review, we depict the possible molecular pathomechanisms of skeletal muscle energetic impairment and postulate iron deficiency as an important factor causally linked to loss of muscle oxidative capacity that contributes to skeletal myopathy seen in patients with heart failure, chronic obstructive pulmonary disease, and type 2 diabetes mellitus...
September 4, 2018: Journal of Cachexia, Sarcopenia and Muscle
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