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metabolism and heart failure

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https://www.readbyqxmd.com/read/29331689/baicalin-inhibits-pressure-overload-induced-cardiac-fibrosis-through-regulating-ampk-tgf-%C3%AE-smads-signaling-pathway
#1
Yichuan Xiao, Jiantao Ye, Ying Zhou, Junjun Huang, Xiawen Liu, Biyun Huang, Liu Zhu, Bo Wu, Genshui Zhang, Yi Cai
AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways. It has been shown that activation of AMPK could inhibit fibroblast proliferation and extracellular matrix (ECM) accumulation, thereby suppressing cardiac fibrosis. Baicalin, the major component found in skullcap, possesses multiple protective effects on the cardiovascular system. However, little is known about the effect of baicalin on cardiac fibrosis and the molecular mechanism by which baicalin exerts its anti-fibrotic effects has not been investigated...
January 10, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29331057/manifestations-and-mechanisms-of-myocardial-lipotoxicity-in-obesity
#2
Arthur C Sletten, Linda R Peterson, Jean E Schaffer
Environmental and socioeconomic changes over the past thirty years have contributed to a dramatic rise in the worldwide prevalence of obesity. Heart disease is among the most serious health risks of obesity, with increases in both atherosclerotic coronary heart disease and heart failure among obese individuals. In this review, we focus on primary myocardial alterations in obesity that include hypertrophic remodeling and diastolic dysfunction. Obesity-associated perturbations in myocardial and systemic lipid metabolism are important contributors to cardiovascular complications of obesity...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29330424/metagenomic-and-metabolomic-analyses-unveil-dysbiosis-of-gut-microbiota-in-chronic-heart-failure-patients
#3
Xiao Cui, Lei Ye, Jing Li, Ling Jin, Wenjie Wang, Shuangyue Li, Minghui Bao, Shouling Wu, Lifeng Li, Bin Geng, Xin Zhou, Jian Zhang, Jun Cai
Previous studies suggested a possible gut microbiota dysbiosis in chronic heart failure (CHF). However, direct evidence was lacking. In this study, we investigated the composition and metabolic patterns of gut microbiota in CHF patients to provide direct evidence and comprehensive understanding of gut microbiota dysbiosis in CHF. We enrolled 53 CHF patients and 41 controls. Metagenomic analyses of faecal samples and metabolomic analyses of faecal and plasma samples were then performed. We found that the composition of gut microbiota in CHF was significantly different from controls...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330215/mir-195-regulates-metabolism-in-failing-myocardium-via-alterations-in-sirt3-expression-and-mitochondrial-protein-acetylation
#4
Xiaokan Zhang, Ruiping Ji, Xianghai Liao, Estibaliz Castillero, Peter J Kennel, Danielle L Brunjes, Marcus Franz, Sven Möbius-Winkler, Konstantinos Drosatos, Isaac George, Emily I Chen, Paolo C Colombo, P Christian Schulze
Background -Heart failure (HF) leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The mitochondrial deacetylase sirtuin 3 (SIRT3) plays a pivotal role in the maintenance of mitochondrial function through regulating the mitochondrial acetylome. Interestingly, unique cardiac and systemic miRNAs have been shown to play an important role in cardiac remodeling by modulating key signaling elements in the myocardium...
January 12, 2018: Circulation
https://www.readbyqxmd.com/read/29326279/gut-microbiota-in-cardiovascular-disease-and-heart-failure
#5
REVIEW
Takeshi Kitai, W H Wilson Tang
Accumulating evidence supports a relationship between the complexity and diversity of the gut microbiota and host diseases. In addition to alterations in the gut microbial composition, the metabolic potential of gut microbiota has been identified as a contributing factor in the development of diseases. Recent technological developments of molecular and biochemical analyses enable us to detect and characterize the gut microbiota via assessment and classification of its genomes and corresponding metabolites. These advances have provided emerging data supporting the role of gut microbiota in various physiological activities including host metabolism, neurological development, energy homeostasis, and immune regulation...
January 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29319170/sirt6-deacetylase-transcriptionally-regulates-glucose-metabolism-in-heart
#6
Danish Khan, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit Shriniwas Pandit, Sneha Mishra, Faiz Ahamed, Abhinav Dubey, Nowrin Fathma, Hanudatta S Atreya, Ullas Kolthur-Seetharam, Nagalingam R Sundaresan
Sirtuins are a family of enzymes, which govern a number of cellular processes essential for maintaining physiological balance. SIRT6, a nuclear localized sirtuin, is implicated in the development of metabolic disorders. The role of SIRT6 in regulation of cardiac metabolism is unexplored. Although glucose is not the primary energy source of heart, defects in glucose oxidation have been linked to heart failure. SIRT6+/- mice hearts exhibit increased inhibitory phosphorylation of PDH subunit E1α. SIRT6 deficiency enhances FoxO1 nuclear localization that results in increased expression of PDK4...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29317401/acute-and-chronic-increases-of-circulating-fstl1-normalize-energy-substrate-metabolism-in-pacing-induced-heart-failure
#7
Mitsuru Seki, Jeffery C Powers, Sonomi Maruyama, Maria A Zuriaga, Chia-Ling Wu, Clara Kurishima, Lydia Kim, Jesse Johnson, Anthony Poidomani, Tao Wang, Eric Muñoz, Sudarsan Rajan, Joon Y Park, Kenneth Walsh, Fabio A Recchia
BACKGROUND: FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and is found to be cardioprotective in animal models of cardiac injury. We tested the hypothesis that circulating FSTL1 can affect cardiac function and metabolism under baseline physiological conditions and in HF. METHODS AND RESULTS: FSTL1 was acutely (10 minutes) or chronically (2 weeks) infused to attain clinically relevant blood levels in conscious dogs with cardiac tachypacing-induced HF...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29313373/the-prognostic-significance-of-improvement-in-exercise-capacity-in-heart-failure-patients-who-participate-in-cardiac-rehabilitation-programme
#8
Avi Sabbag, Israel Mazin, David Rott, Ilan Hay, Nelly Gang, Boaz Tzur, Ronen Goldkorn, Ilan Goldenberg, Robert Klempfner, Ariel Israel
Introduction There are limited contemporary data regarding the association between improvement in cardiovascular fitness in heart failure patients who participate in a cardiac rehabilitation programme and the risk of subsequent hospitalisations. Methods The study population comprised 421 patients with heart failure who participated in our cardiac rehabilitation programme between the years 2009 and 2016. All were evaluated by a standard exercise stress test before initiation, and underwent a second exercise stress test on completion of 3 ± 1 months of training...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29311763/the-acute-effects-of-a-multi-ingredient-pre-workout-supplement-on-resting-energy-expenditure-and-exercise-performance-in-recreationally-active-females
#9
Michael Cameron, Clayton L Camic, Scott Doberstein, Jacob L Erickson, Andrew R Jagim
Background: The use of dietary supplements to improve performance is becoming increasingly popular among athletes and fitness enthusiasts. Unfortunately, there is a tremendous lack of research being done regarding female athletes and the use of sport supplements. The purpose of this study was to examine the acute effects of multi-ingredient pre-workout supplement (MIPS) ingestion on resting metabolism and exercise performance in recreationally-active females. Methods: Fifteen recreationally-active females participated in a randomized, double-blind, placebo controlled study...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29306730/role-of-metabolic-syndrome-on-perioperative-and-oncological-outcomes-at-radical-prostatectomy-in-a-low-risk-prostate-cancer-cohort-potentially-eligible-for-active-surveillance
#10
Michele Colicchia, Alessandro Morlacco, Laureano J Rangel, Rachel E Carlson, Fabrizio Dal Moro, R Jeffrey Karnes
BACKGROUND: Metabolic syndrome (MetS) is considered a potential risk factor for adverse outcomes after radical prostatectomy (RP). Furthermore, studies about the effect of MetS on low-risk prostate cancer (PCa) and its implications in active surveillance (AS) are limited. OBJECTIVE: To investigate the role of MetS (using International Diabetes Federation-American Heart Association/National Heart, Lung, and Blood Institute criteria) on perioperative and oncological outcomes after RP in low-risk PCa and in a subgroup potentially eligible for AS...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29301869/astragaloside-iv-inhibits-ventricular-remodeling-and-improves-fatty-acid-utilization-in-rats-with-chronic-heart-failure
#11
Bin Tang, Jin-Guo Zhang, Hong-Yong Tan, Xi-Qing Wei
Chronic heart failure (CHF) is the end-stage of many cardiovascular diseases and severely affects the patients' lifespan. Inhibiting ventricular remodeling is thus a primary treatment target for CHF patients. Astragaloside IV (AS-IV) can improve cardiac function and protect myocardial cells. The study aims to investigate the effects of AS-IV on ventricular remodeling and explore its role in regulating energy metabolism using a rat CHF model. Sprague Dawley rats were divided into 5 groups (N=20 per group):  CHF + benazepril hydrochloride, CHF + low-dose (30 mg...
January 4, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29299604/association-of-acylcarnitines-with-left-ventricular-remodeling-in-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#12
Sammy Elmariah, Laurie A Farrell, Deborah Furman, Brian R Lindman, Xu Shi, Jordan E Morningstar, Eugene P Rhee, Robert E Gerszten
Importance: Clinical practice guidelines currently endorse a reliance on clinical symptoms of overt left ventricular (LV) failure to time aortic valve replacement for severe aortic stenosis; however, delayed aortic valve replacement can result in irreversible LV injury and adverse outcomes. Blood metabolomic signatures possess prognostic value in heart failure; this study assesses whether they are informative in aortic stenosis. Objective: To evaluate the value of metabolomic signatures in reflecting the extent of maladaptive LV remodeling in patients with end-stage aortic stenosis undergoing transcatheter aortic valve replacement, and to assess whether this procedure reverses metabolomic aberrations...
January 3, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29289652/cellular-mechanisms-of-metabolic-syndrome-related-atrial-decompensation-in-a-rat-model-of-hfpef
#13
Felix Hohendanner, David Bode, Uwe Primessnig, Tim Guthof, Rafael Doerr, Sarah Jeuthe, Sophie Reimers, Kun Zhang, Doris Bach, Paulina Wakula, Burkert M Pieske, Frank R Heinzel
Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We postulate that atrial remodeling is associated with atrial dysfunction in vivo related to alterations in cardiomyocyte Calcium (Ca) signaling and remodeling. We examined atrial function in vivo and Ca transients (CaT) (Fluo4-AM, field stim) in atrial cardiomyocytes of ZSF-1 rats without (Ln; lean hypertensive) and with metabolic syndrome (Ob; obese, hypertensive, diabetic) and HFpEF...
December 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29288718/kr%C3%A3-ppel-like-factor-15-regulator-of-bcaa-metabolism-and-circadian-protein-rhythmicity
#14
REVIEW
Liyan Fan, Paishiun N Hsieh, David R Sweet, Mukesh K Jain
Regulation of nutrient intake, utilization, and storage exhibits a circadian rhythmicity that allows organisms to anticipate and adequately respond to changes in the environment across day/night cycles. The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important modulators of metabolism and metabolic health - for example, their catabolism yields carbon substrates for gluconeogenesis during periods of fasting. Krüppel-like factor 15 (KLF15) has recently emerged as a critical transcriptional regulator of BCAA metabolism, and the absence of this transcription factor contributes to severe pathologies such as Duchenne muscular dystrophy and heart failure...
December 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29286988/cardiovascular-and-metabolic-morbidity-after-hysterectomy-with-ovarian-conservation-a-cohort-study
#15
Shannon K Laughlin-Tommaso, Zaraq Khan, Amy L Weaver, Carin Y Smith, Walter A Rocca, Elizabeth A Stewart
OBJECTIVE: The aim of the study was to determine the long-term risk of cardiovascular disease and metabolic conditions in women undergoing hysterectomy with bilateral ovarian conservation compared with age-matched referent women. METHODS: Using the Rochester Epidemiology Project records-linkage system, we identified 2,094 women who underwent hysterectomy with ovarian conservation for benign indications between 1980 and 2002 in Olmsted County, Minnesota. Each woman was age-matched (±1 y) to a referent woman residing in the same county who had not undergone prior hysterectomy or any oophorectomy...
December 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29277329/human-embryonic-stem-cell-derived-cardiomyocytes-as-an-in-vitro-model-to-study-cardiac-insulin-resistance
#16
Ilvy M E Geraets, Dipanjan Chanda, Florence H J van Tienen, Arthur van den Wijngaard, Rick Kamps, Dietbert Neumann, Yilin Liu, Jan F C Glatz, Joost J F P Luiken, Miranda Nabben
Patients with type 2 diabetes (T2D) and/or insulin resistance (IR) have an increased risk for the development of heart failure (HF). Evidence indicates that this increased risk is linked to an altered cardiac substrate preference of the insulin resistant heart, which shifts from a balanced utilization of glucose and long-chain fatty acids (FAs) towards an almost complete reliance on FAs as main fuel source. This shift leads to a loss of endosomal proton pump activity and increased cardiac fat accumulation, which eventually triggers cardiac dysfunction...
December 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29276930/-perfusion-metabolic-myocardial-scintigraphy-in-prognosis-of-left-ventricular-remodeling-after-complex-surgical-treatment-of-ischemic-cardiomyopathy
#17
Y B Lishmanov, M O Gulya, K V Zavadovsky, S L Andreev, E A Alexandrova
PURPOSE: To study capabilities of perfusion-metabolic myocardial scintigraphy for prediction of the left ventricular (LV) reverse remodeling after comprehensive surgical treatment of ischemic cardiomyopathy (ICMP). METHODS: The study included ICMP patients aged 56±7 years (n=32) who underwent surgical correction of LV dysfunction (myocardial revascularization, LV reconstruction, and mitral valve restoration). Inclusion criteria were significant coronary artery disease; myocardial infarction; New York Heart Association (NYHA) class III-IV heart failure; LV ejection fraction (EF) ≤45%; LV end-systolic index (ESI) >60 mL/m2; and LV akinesia or dyskinesia according to echocardiography...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29260292/vitamin-d-supplementation-and-bone-turnover-in-advanced-heart-failure-the-evita-trial
#18
A Zittermann, J B Ernst, S Prokop, U Fuchs, J Dreier, J Kuhn, H K Berthold, S Pilz, I Gouni-Berthold, J F Gummert
Low vitamin D status is common in patients with heart failure and may influence bone health. A daily vitamin D dose of 4000 IU (moderately high dose) for 3 years had however no effect on parameters of bone metabolism, even in patients with very low vitamin D status. INTRODUCTION: Low vitamin D status is common in patients with heart failure (HF) and has been related to disturbed bone turnover. The present study investigated the effect of a daily vitamin D3 dose of 4000 IU on bone turnover markers (BTMs) in patients with advanced HF and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29251652/post-discharge-light-intensity-physical-activity-predicts-rehospitalization-of-older-japanese-patients-with-heart-failure
#19
So Miyahara, Naoki Fujimoto, Kaoru Dohi, Emiyo Sugiura, Keishi Moriwaki, Taku Omori, Tetsushiro Takeuchi, Naoto Kumagai, Shiro Nakamori, Norikazu Yamada, Masaaki Ito
PURPOSE: Regular physical activity (PA) is recommended for patients with heart failure (HF). However, the clinical and social characteristics of older HF patients with low-level PA and the impact of light-intensity PA on 6-mo post-discharge adverse cardiovascular events are still unclear. METHODS: Forty-one older patients who had been admitted because of decompensated HF (American College of Cardiology [ACC]/American Heart Association [AHA] HF classification stage C/D: 76 ± 5 y) were prospectively enrolled...
December 14, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29247377/ccn5-wisp2-and-metabolic-diseases
#20
REVIEW
John R Grünberg, Johannes Elvin, Alexandra Paul, Shahram Hedjazifar, Ann Hammarstedt, Ulf Smith
Obesity and type 2 diabetes increase worldwide at an epidemic rate. It is expected that by the year 2030 around 500 million people will have diabetes; predominantly type 2 diabetes. The CCN family of proteins has become of interest in both metabolic and other common human diseases because of their effects on mesenchymal stem cell (MSCs) proliferation and differentiation as well as being important regulators of fibrosis. We here review current knowledge of the WNT1 inducible signaling pathway protein 2 (CCN5/WISP2)...
December 15, 2017: Journal of Cell Communication and Signaling
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