keyword
https://read.qxmd.com/read/38346008/blood-brain-barrier-penetrating-and-lesion-targeting-nanoplatforms-inspired-by-the-pathophysiological-features-for-synergistic-ischemic-stroke-therapy
#21
JOURNAL ARTICLE
Lu Tang, Yue Yin, Hening Liu, Mengliang Zhu, Yuqi Cao, Jingwen Feng, Cong Fu, Zixuan Li, Weijie Shu, Jifan Gao, Xing-Jie Liang, Wei Wang
Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due to its complicated pathophysiological features, current treatment options after ischemic stroke attack remains unsatisfactory. Insufficient drug delivery to ischemic lesions impeded by the blood-brain barrier (BBB) largely limits the therapeutic efficacy of most anti-stroke agents. Herein, inspired by the rapid BBB penetrability of 4T1 tumor cells upon their brain metastasis and natural roles of platelet in targeting injured vasculatures, a bio-derived nanojacket was developed by fusing 4T1 tumor cell membrane with platelet membrane, which further clothed on the surface of paeonol and polymetformin-loaded liposome to obtain biomimetic nanoplatforms (PP@PCL) for ischemic stroke treatment...
February 12, 2024: Advanced Materials
https://read.qxmd.com/read/38342016/neuroprotection-of-rhubarb-extract-against-cerebral-ischaemia-reperfusion-injury-via-the-gut-brain-axis-pathway
#22
JOURNAL ARTICLE
Mingjiang Mao, Xingqin Cao, Yuhua Liang, Qiuying Li, Simiao Chen, Liping Zhou, Yuyan Zhang, Ying Guo
BACKGROUND: The gut-brain axis (GBA) plays a central role in cerebral ischaemia-reperfusion injury (CIRI). Rhubarb, known for its purgative properties, has demonstrated protective effects against CIRI. However, it remains unclear whether this protective effect is achieved through the regulation of the GBA. AIM: This study aims to investigate the mechanism by which rhubarb extract improves CIRI by modulating the GBA pathway. METHODS: We identified the active components of rhubarb extract using LC-MS/MS...
February 1, 2024: Phytomedicine
https://read.qxmd.com/read/38336256/echinatin-protects-from-ischemic-brain-injury-by-attenuating-nlrp3-related-neuroinflammation
#23
JOURNAL ARTICLE
Liang Sun, Duo Chen, Chenchen Zhao, Yujie Hu, Yuhao Xu, Shengnan Xia, Haiyan Yang, Xinyu Bao, Zhi Zhang, Chao Zhou, Qingxiu Zhang, Yun Xu
BACKGROUND: Microglia-mediated neuroinflammation is the major contributor to the secondary brain injury of ischemic stroke. NLRP3 is one of the major components of ischemia-induced microglial activation. Echinatin, a chalcone found in licorice, was reported to have the activity of anti-inflammation and antioxidant. However, the relative study of echinatin in microglia or ischemic stroke is still unclear. METHODS: We intravenously injected echinatin or vehicle into adult ischemic male C57/BL6J mice induced by 60-min transient middle cerebral artery occlusion (tMCAO)...
February 7, 2024: Neurochemistry International
https://read.qxmd.com/read/38229322/netrin-1-protects-blood-brain-barrier-bbb-integrity-after-cerebral-ischemia-reperfusion-by-activating-the-kruppel-like-factor-2-klf2-occludin-pathway
#24
JOURNAL ARTICLE
Yuanxiao Li, Changyun Liu, Zhiting Chen, Hanbin Lin, Xiaofeng Li
Ischemia/reperfusion (I/R)-induced neural damage and neuroinflammation have been associated with pathological progression during stroke. Netrin-1 is an important member of the family of laminin-related secreted proteins, which plays an important role in governing axon elongation. However, it is unknown whether Netrin-1 possesses a beneficial role in stroke. Here, we employed the middle cerebral artery occlusion (MCAO) model to study the function of Netrin-1 in alleviating brain injuries. Our results demonstrate that Netrin-1 rescued poststroke neurological deficits and inhibited production of the inflammatory cytokines such as interleukin 6 (IL-6) and endothelial chemokine (C-X-C motif) ligand 1 (Cxcl1)...
January 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38217003/a-slow-releasing-donor-of-hydrogen-sulfide-inhibits-neuronal-cell-death-via-anti-panoptosis-in-rats-with-spinal-cord-ischemia%C3%A2-reperfusion-injury
#25
JOURNAL ARTICLE
Lei Xie, Hang Wu, Qiuping He, Weipeng Shi, Jing Zhang, Xiao Xiao, Tengbo Yu
BACKGROUND: Spinal cord ischemia‒reperfusion injury (SCIRI) can lead to paraplegia, which leads to permanent motor function loss. It is a disastrous complication of surgery and causes tremendous socioeconomic burden. However, effective treatments for SCIRI are still lacking. PANoptosis consists of three kinds of programmed cell death, pyroptosis, apoptosis, and necroptosis, and may contribute to ischemia‒reperfusion-induced neuron death. Previous studies have demonstrated that hydrogen sulfide (H2 S) exerts a neuroprotective effect in many neurodegenerative diseases...
January 12, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38154533/enhanced-the-treatment-of-ischemic-stroke-through-intranasal-temperature-sensitive-hydrogels-of-edaravone-and-borneol-inclusion-complex
#26
JOURNAL ARTICLE
Chuanhui Teng, Wei Lv, Yuqin Chen, Linfeng Liu, Jiaqing Yin, Shengnan Li, Zhiyi Min, Qi Zhang, Weichong He, Kunfang Ma, Xinrui Li, Xiang Cao, Hongliang Xin
Since ischemic stroke occurs by a combination of multiple mechanisms, therapies that modulate multiple mechanisms are required for its treatment. The combination of edaravone (EDA) and borneol can significantly ameliorate the symptoms of neurological deficits in cerebral ischemia-reperfusion model in rats. In this study, the solubility of borneol and edaravone was improved by hydroxypropyl-β-cyclodextrin and PEG400 . Furthermore, a nasal temperature-sensitive hydrogel containing both edaravone and borneol inclusion complex (EDA-BP TSGS ) was developed to overcome the obstacles of ischemic stroke treatment including the obstruction of the blood-brain barrier (BBB) and the unavailability and untimely of intravenous injection...
December 26, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/38148633/mmp-2-mediated-scube2-degradation-promotes-blood-brain-barrier-disruption-by-blocking-the-interaction-between-astrocytes-and-endothelial-cells-via-inhibiting-sonic-hedgehog-pathway-during-early-cerebral-ischemia
#27
JOURNAL ARTICLE
Tengrui Shi, Shiqin Yue, Cong Xie, Xiaofeng Li, Dexin Yang, Linghui Hu, Yunxue Zhong, Yuan Zhang, Wenlan Liu
We have previously demonstrated a rapid secretion of matrix metalloproteinase-2 (MMP-2) in the ischemic brain. Since Scube2 can interact with Sonic hedgehog (Shh) to maintain blood-brain barrier (BBB) integrity via regulating the interaction between brain capillary endothelial cells (ECs) and perivascular astrocytes, and it is also a substrate of MMP-2, we hypothesized that the secreted MMP-2 could degrade Scube2 and contribute to ischemic BBB disruption. Using an in vitro ischemic model of 90-min oxygen-glucose deprivation/3-h reoxygenation (OGD/R) and an in vivo mouse stroke model of 90-min middle cerebral artery occlusion (MCAO) with 3-h reperfusion, we established an important role of MMP-2-mediated Scube2 degradation in early ischemic BBB disruption...
December 26, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/38145861/danlou-tablet-attenuates-ischemic-stroke-injury-and-blood%C3%A2-brain-barrier-damage-by-inhibiting-ferroptosis
#28
JOURNAL ARTICLE
Chang Liu, Enran Liu, Zhixi Li, Wenqiang Li, Jiaqi Jin, Haijing Sui, Guangmin Chen, Zhenyu Sun, Hongjie Xi
ETHNOPHARMACOLOGICAL RELEVANCE: Danlou tablet (DLT) is a traditional Chinese medicinal formulation known for replenishing Qi, promoting blood circulation, and resolving stasis. Its pharmacological actions primarily involve anti-inflammatory, antioxidant stress reduction, antiapoptotic, proangiogenic, and improved energy metabolism. DLT has been confirmed to have favorable therapeutic effects on ischemic stroke (IS). However, the underlying mechanism through which DLT affects IS-induced brain injury remains unknown...
December 23, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38145295/cenicriviroc-prevents-dysregulation-of-astrocyte-endothelial-cross-talk-induced-by-ischemia-and-hiv-1-via-inhibiting-the-nlrp3-inflammasome-and-pyroptosis
#29
JOURNAL ARTICLE
Nikolai Fattakhov, Alex Ngo, Silvia Torices, Joelle-Ann Joseph, Adesuwa Okoro, Cameron Moore, Oandy Naranjo, Sarah Becker, Michal Toborek
Blood-brain barrier (BBB) breakdown is one of the pathophysiological characteristics of ischemic stroke, which may contribute to the progression of brain tissue damage and subsequent neurological impairment. HIV-infected individuals are at greater risk for ischemic stroke due to diminished immune function and HIV-associated vasculopathy. Studies have shown that astrocytes are involved in maintaining BBB integrity and facilitating HIV-1 infection in the brain. The present study investigated whether targeting astrocyte-endothelial cell signaling with cenicriviroc (CVC), a dual CCR2 and CCR5 antagonist, may protect against dysregulation of cross talk between these cells after oxygen-glucose deprivation/reoxygenation (OGD/R) combined with HIV-1 infection...
December 25, 2023: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38118299/novel-1-3-4-oxadiazole-hybrids-of-3-n-butylphthalide-derivatives-as-potential-anti-ischemic-stroke-agents
#30
JOURNAL ARTICLE
Qinyang Yu, Yong Li, Zhongfu Luo, Wenjing Liu, Taigui Ma, Bilan Luo, Judi Fan, Yi Li, Bing Guo, Lei Tang, Lingling Fan
In continuation of our program to search for novel potential anti-ischemic stroke agents, a series of 1,3,4-oxadiazole and sulfoxide hybrids of phthalide derivatives was designed and synthesized in this study to evaluate their anti-ischemic stroke activity. Among them, compounds 5b, 5d, 5 l, and 5 m exhibited excellent inhibitory effects on platelet aggregation induced by adenosine diphosphate (ADP) and arachidonic acid (AA). In particular, compound 5b possessed considerable antithrombotic activity in animal models, as demonstrated by the effective alleviation of carrageenan-induced and FeCl3 -induced thrombosis in tail and carotid arteries, respectively...
December 16, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/38113968/levofloxacin-alleviates-blood-brain-barrier-disruption-following-cerebral-ischemia-and-reperfusion-via-directly-inhibiting-a-fabp
#31
JOURNAL ARTICLE
Shilun Yang, Dingkang Xu, Dianhui Zhang, Xiaowen Huang, Simeng Li, Yan Wang, Jing Lu, Daming Wang, Zhen-Ni Guo, Yi Yang, Dewei Ye, Yu Wang, Aimin Xu, Ruby Lai Chong Hoo, Junlei Chang
Reperfusion therapy is currently the most effective treatment for acute ischemic stroke, but often results in secondary brain injury. Adipocyte fatty acid-binding protein (A-FABP, FABP4, or aP2) was shown to critically mediate cerebral ischemia/reperfusion (I/R) injury by exacerbating blood-brain barrier (BBB) disruption. However, no A-FABP inhibitors have been approved for clinical use due to safety issues. Here, we identified the therapeutic effect of levofloxacin, a widely used antibiotic displaying A-FABP inhibitory activity in vitro, on cerebral I/R injury and determined its target specificity and action mechanism in vivo...
December 17, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/38042462/gpr124-induces-nlrp3-inflammasome-mediated-pyroptosis-in-endothelial-cells-during-ischemic-injury
#32
JOURNAL ARTICLE
Yiqian Xu, Xingyue Fang, Zhenqiang Zhao, Haolin Wu, Haofei Fan, Ya Zhang, Qingwen Meng, Qiongwen Rong, Kohji Fukunaga, Qingyun Guo, Qibing Liu
OBJECTIVE: G protein-coupled receptor 124 (GPR124) regulates central nervous system angiogenesis and blood-brain barrier (BBB) integrity, and its deficiency aggravates BBB breakdown and hemorrhagic transformation in ischemic mice. However, excessive GPR124 expression promotes inflammation in atherosclerotic mice. In this study, we aimed to elucidate the role of GPR124 in hypoxia/ischemia-induced cerebrovascular endothelial cell injury. METHODS: bEnd.3 cells were exposed to oxygen-glucose deprivation (OGD), and time-dependent changes in GPR124 mRNA and protein expression were evaluated using reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting...
December 1, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/38037097/single-cell-rna-sequencing-unveils-lrg1-s-role-in-cerebral-ischemia%C3%A2-reperfusion-injury-by-modulating-various-cells
#33
JOURNAL ARTICLE
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv
BACKGROUND AND PURPOSE: Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies that target multiple cell components are urgently needed. Leucine-rich alpha-2 glycoprotein 1 (Lrg1) appears to be associated with the progression of cerebral ischemia‒reperfusion injury, but the exact mechanism of it is unknown...
November 30, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/38019326/se-methyl-selenocysteine-ameliorates-blood-brain-barrier-disruption-of-focal-cerebral-ischemia-mice-via-ferroptosis-inhibition-and-tight-junction-upregulation-in-an-akt-gsk3%C3%AE-dependent-manner
#34
JOURNAL ARTICLE
Yuxiang Fei, Tao Li, Ruoyu Wu, Xuejiao Xu, Sheng Hu, Ya Yang, Chenchen Jin, Wenlian Tang, Xu Zhang, Qianming Du, Chao Liu
BACKGROUND: Ischemic stroke still ranks as the most fatal disease worldwide. Blood-brain barrier (BBB) is a promising therapeutic target for protection. Brain microvascular endothelial cell is a core component of BBB, the barrier function maintenance of which can ameliorate ischemic injury and improve neurological deficit. Se-methyl L-selenocysteine (SeMC) has been shown to exert cardiovascular protection. However, the protection of SeMC against ischemic stroke remains to be elucidated...
November 29, 2023: Psychopharmacology
https://read.qxmd.com/read/37980971/interfering-trib3-protects-the-blood-brain-barrier-through-pi3k-akt-pathway-to-alleviate-cerebral-ischemia-reperfusion-injury-in-diabetes-mellitus-mice
#35
JOURNAL ARTICLE
Heng-Jun Zhou, Xiao-Yi Wang, Li-Qing Wang, Jie-Sheng Zheng, Ren-Ya Zhan, Jian-Wei Pan
This study aimed to treat diabetic cerebral ischemia-reperfusion injury (CI/RI) by affecting blood brain barrier (BBB) permeability and integrity. The CI/RI model in DM mice and a high glucose (HG) treated oxygen and glucose deprivation/reoxygenation (OGD/R) brain endothelial cell model were established for the study. Evans blue (EB) staining was used to evaluate the permeability of BBB in vivo. TTC staining was used to analyze cerebral infarction. The location and expression of tribbles homolog 3 (TRIB3) in endothelial cells were detected by immunofluorescence...
November 17, 2023: Chemico-biological Interactions
https://read.qxmd.com/read/37967793/akkermansia-muciniphila-derived-small-extracellular-vesicles-attenuate-intestinal-ischemia-reperfusion-induced-postoperative-cognitive-dysfunction-by-suppressing-microglia-activation-via-the-tlr2-4-signaling
#36
JOURNAL ARTICLE
Xiang Gao, Chuantao Lin, Yebin Feng, Yi You, Zhe Jin, Mengyun Li, Yufeng Zhou, Kai Chen
Akkermansia muciniphila (AKK) bacteria improve the functions of theere intestinal and blood-brain barriers (BBB) via their extracellular vesicles (AmEvs). However, their role in postoperative cognitive dysfunction (POCD) and its underlying mechanisms remain unclear. To investigate, we used C57BL/6 J mice divided into five groups: Sham, POCD, POCD+Akk, POCD+Evs, and POCD+Evs + PLX5622. POCD was induced through intestinal ischemia-reperfusion (I/R). The mice's cognitive function was assessed using behavioral tests, and possible mechanisms were explored by examining gut and BBB permeability, inflammation, and microglial function...
November 13, 2023: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/37950788/nuclear-factor-erythroid-2-related-factor-2-is-essential-for-low-normobaric-oxygen-treatment-mediated-blood-brain-barrier-protection-following-ischemic-stroke
#37
JOURNAL ARTICLE
Xiao-Xiao Ma, Hai-Yi Xie, Pin-Pin Hou, Xiao-Jing Wang, Wei Zhou, Zhen-Hong Wang
Cerebral ischemia/reperfusion (I/R) injury increases blood-brain barrier (BBB) permeability, leading to hemorrhagic transformation and brain edema. Normobaric oxygen (NBO) is a routine clinical treatment strategy for this condition. However, its neuroprotective effects remain controversial. This study investigated the effect of different NBO concentrations on I/R injury and explores the involvement of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the underlying mechanism. A mouse middle cerebral artery occlusion (MCAO) model, and an oxygen and glucose deprivation (OGD) model featuring mouse brain microvascular endothelial cells (ECs) called bEnd...
November 11, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37949291/downregulation-of-nrp1-transcription-promotes-blood-brain-barrier-disruption-following-experimental-cerebral-ischemia-reperfusion
#38
JOURNAL ARTICLE
Xiang Xu, Gang Chen, Hai Zhou, Yangyang Liu, Haojie Ding, Zongqi Wang, Haitao Shen, Xiang Li, Haiying Li
Disruption of the blood-brain barrier (BBB) following cerebral ischemia-reperfusion injury (CIRI) is a major factor in the pathophysiology of stroke. Endothelial cell-cell communication is essential for maintaining BBB integrity. By analyzing GSE227651 data, we found that a decrease in endothelial cell-cell communication mediated by Sema3/Nrp1 may be due to the downregulation of Nrp1 transcription, which could contribute to BBB breakdown after CIRI. We confirmed this hypothesis by using western blot analysis to show a reduction in Nrp1 protein levels in penumbra endothelial cells after CIRI in mice...
November 8, 2023: Neuroscience Letters
https://read.qxmd.com/read/37946257/panax-notoginseng-derived-exosome-like-nanoparticles-attenuate-ischemia-reperfusion-injury-via-altering-microglia-polarization
#39
JOURNAL ARTICLE
Shiyi Li, Ru Zhang, Anni Wang, Yang Li, Miaomiao Zhang, Jisu Kim, Ying Zhu, Qizheng Wang, Yue Zhang, Ying Wei, Jianxin Wang
Cerebral ischemia/reperfusion (CI/R) injury is a clinical conundrum during the treatment of ischemic stroke. Cell-derived exosomes (CDE) were proved to be therapeutically effective for CI/R injury. However, production of CDE is time and effort consuming. Increasing studies reported that plants can also generate exosome-like nanoparticles (ELN) which are therapeutically effective and have higher yield compared with CDE. In this study, a commonly used Chinese herb Panax notoginseng (PN), whose active ingredients were well-documented in the treatment of CI/R injury, was chosen as a source of ELNs...
November 10, 2023: Journal of Nanobiotechnology
https://read.qxmd.com/read/37939854/astrocytes-and-microglia-targeted-danshensu-liposomes-enhance-the-therapeutic-effects-on-cerebral-ischemia-reperfusion-injury
#40
JOURNAL ARTICLE
Min Bai, Na Cui, Yucheng Liao, Chao Guo, Liang Li, Ying Yin, Aidong Wen, Jingwen Wang, Weiliang Ye, Yi Ding
Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in stroke without satisfactory therapeutic effect. Inflammation mediated by activation of astrocytes and microglia is the main pathological mechanism of CI/RI. Danshensu (DSS) has been shown to exert anti-inflammatory effects against brain injury. However, limited by its poor cellular permeability and low bioavailability, it is still needed the new DSS preparations with the ability to cross the blood-brain barrier (BBB) and target inflammatory glial cells...
November 6, 2023: Journal of Controlled Release
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