keyword
MENU ▼
Read by QxMD icon Read
search

Bbb reperfusion

keyword
https://www.readbyqxmd.com/read/28322975/a-polymeric-micelle-magnetic-resonance-imaging-mri-contrast-agent-reveals-blood-brain-barrier-bbb-permeability-for-macromolecules-in-cerebral-ischemia-reperfusion-injury
#1
Kouichi Shiraishi, Zuojun Wang, Daisuke Kokuryo, Ichio Aoki, Masayuki Yokoyama
Blood-brain barrier (BBB) opening is a key phenomenon for understanding ischemia-reperfusion injuries that are directly linked to hemorrhagic transformation. The recombinant human tissue-type plasminogen activator (rtPA) increases the risk of symptomatic intracranial hemorrhages. Recent imaging technologies have advanced our understanding of pathological BBB disorders; however, an ongoing challenge in the pre-"rtPA treatment" stage is the task of developing a rigorous method for hemorrhage-risk assessments...
March 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28290606/3-daidzein-sulfonate-sodium-inhibits-neuronal-apoptosis-induced-by-cerebral-ischemia-reperfusion
#2
Ruizhen Liu, Xinming Zhong, Jing Zeng, Zhihua Huang, Xiao Li, Hai Xiao, Qin Chen, Dongliang Li
This study aimed to observe the effects of 3'-daidzein sulfonate sodium (DSS) on ischemia-reperfusion-induced brain injury and to analyze the mechanisms responsible for neuronal apoptosis. Focal ischemias were induced in male Sprague-Dawley rats using middle cerebral artery occlusion. The rats were divided into 5 groups based on sham surgery or real occlusion, and treatment with different doses of DSS (0.5, 1.0 and 2.0 mg/kg) or normal saline (model group), injected preoperatively into the rats with cerebral occlusion...
March 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28285147/protective-roles-of-nanomelatonin-in-cerebral-ischemia-reperfusion-of-aged-brain-matrixmetalloproteinases-as-regulators
#3
Sibani Sarkar, Abhishek Mukherjee, Nirmalendu Das, Snehasikta Swarnakar
Cerebral ischemia-reperfusion (CIR) injury occurs as a result of oxygen occlusion in the carotid artery through embolus or thrombus formation or cerebrovascular hemorrhage. The oxygen thrust during reperfusion causes the generation of reactive oxidative species (ROS) which exert a potential threat to neuronal survival. ROS may possibly be arrested by antioxidants. After CIR, extracellular matrix remodeling takes place, which is governed by matrix metalloproteinases (MMPs). Augmentation of lipid per oxidation, perturbation of antioxidant enzyme activities and the loss of pyramidal neuronal cells in rat brain were attributed to CIR injury...
March 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28267563/protective-effects-of-angiopoietin-like-4-on-the-blood-brain-barrier-in-acute-ischemic-stroke-treated-with-thrombolysis-in-mice
#4
Bin Zhang, Xiaofeng Xu, Xiuli Chu, Xiaoyang Yu, Yuwu Zhao
AIMS: Given the risk of blood-brain barrier damage (BBB) caused by ischemic and tissue plasminogen activator thrombolysis, the preservation of vascular integrity is important. Angiopoietin-like 4 (ANGPTL4), a protein secreted in hypoxia, is involved in the regulation of vascular permeability. We hypothesized that Angptl4 might exert a protective effect in thrombolysis through stabilizing blood-brain barrier and inhibit hyper-permeability. METHODS: We investigated the role of Angptl4 in stroke using a transient focal cerebral ischemia mouse model...
March 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28251683/limb-remote-ischemic-postconditioning-induced-elevation-of-fibulin-5-confers-neuroprotection-to-rats-with-cerebral-ischemia-reperfusion-injury-activation-of-the-akt-pathway
#5
Wei Zhang, Ye Wang, Guorong Bi
Limb remote ischemic postconditioning (RIPostC) is an effective and well-acknowledged treatment for brain ischemia injury. The present study aimed to evaluate the role of fibulin-5 in the neuroprotection of RIPostC against cerebral ischemia/reperfusion (I/R) injury in rats. The middle cerebral artery occlusion (MCAO) model was established in rats and then RIPostC was carried out by 3 cycles of 10 min occlusion/10 min release of the bilateral femoral artery at the beginning of the reperfusion. To downregulate the fibulin-5 level, fibulin-5 siRNA was injected into the lateral ventricle 24 h before MCAO...
March 2, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28217292/oxygen-or-cooling-to-make-a-decision-after-acute-ischemia-stroke
#6
REVIEW
Wen-Cao Liu, Xin-Chun Jin
The presence of a salvageable penumbra, a region of ischemic brain tissue with sufficient energy for short-term survival, has been widely agreed as the premise for thrombolytic therapy with tissue plasminogen activator (tPA), which remains the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrained due to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic transformation (HT)...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28188848/electroacupuncture-preconditioning-and-postconditioning-inhibit-apoptosis-and-neuroinflammation-induced-by-spinal-cord-ischemia-reperfusion-injury-through-enhancing-autophagy-in-rats
#7
Bo Fang, Meiman Qin, Yun Li, Xiaoqian Li, Wenfei Tan, Ying Zhang, Hong Ma
Electroacupuncture (EA) has beneficial effects on spinal cord ischemia reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study aimed to investigate the role of autophagy in the protection of EA preconditioning and postconditioning against spinal cord I/R injury. For this, spinal cord I/R injury was induced by 14min occlusion of the aortic arch, and rats were treated with EA for 20min before or after the surgery. The expression of autophagy components, light chain 3 and Beclin 1, was assessed by Western blot...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28137866/endothelium-targeted-overexpression-of-heat-shock-protein-27-ameliorates-blood-brain-barrier-disruption-after-ischemic-brain-injury
#8
Yejie Shi, Xiaoyan Jiang, Lili Zhang, Hongjian Pu, Xiaoming Hu, Wenting Zhang, Wei Cai, Yanqin Gao, Rehana K Leak, Richard F Keep, Michael V L Bennett, Jun Chen
The damage borne by the endothelial cells (ECs) forming the blood-brain barrier (BBB) during ischemic stroke and other neurological conditions disrupts the structure and function of the neurovascular unit and contributes to poor patient outcomes. We recently reported that structural aberrations in brain microvascular ECs-namely, uncontrolled actin polymerization and subsequent disassembly of junctional proteins, are a possible cause of the early onset BBB breach that arises within 30-60 min of reperfusion after transient focal ischemia...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28089577/neutralizing-anti-interleukin-1%C3%AE-antibodies-reduce-ischemia-related-interleukin-1%C3%AE-transport-across-the-blood-brain-barrier-in-fetal-sheep
#9
Aparna Patra, Xiaodi Chen, Grazyna B Sadowska, Jiyong Zhang, Yow-Pin Lim, James F Padbury, William A Banks, Barbara S Stonestreet
Hypoxic ischemic insults predispose to perinatal brain injury. Pro-inflammatory cytokines are important in the evolution of this injury. Interleukin-1β (IL-1β) is a key mediator of inflammatory responses and elevated IL-1β levels in brain correlate with adverse neurodevelopmental outcomes after brain injury. Impaired blood-brain barrier (BBB) function represents an important component of hypoxic-ischemic brain injury in the fetus. In addition, ischemia-reperfusion increases cytokine transport across the BBB of the ovine fetus...
March 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28031392/dce-mri-blood-brain-barrier-assessment-in-acute-ischemic-stroke
#10
Kersten Villringer, Borja E Sanz Cuesta, Ann-Christin Ostwaldt, Ulrike Grittner, Peter Brunecker, Ahmed A Khalil, Kristina Schindler, Ole Eisenblätter, Heinrich Audebert, Jochen B Fiebach
OBJECTIVE: To quantitatively evaluate blood-brain barrier changes in ischemic stroke patients using dynamic contrast-enhanced (DCE) MRI. METHODS: We examined 54 stroke patients (clinicaltrials.gov NCT00715533, NCT02077582) in a 3T MRI scanner within 48 hours after symptom onset. Twenty-eight patients had a follow-up examination on day 5-7. DCE T1 mapping and Patlak analysis were employed to assess BBB permeability changes. RESULTS: Median stroke K(trans) values (0...
January 31, 2017: Neurology
https://www.readbyqxmd.com/read/27959885/potassium-aspartate-attenuates-brain-injury-induced-by-controlled-cortical-impact-in-rats-through-increasing-adenosine-triphosphate-atp-levels-na-k-atpase-activity-and-reducing-brain-edema
#11
Yi Gu, Jie Zhang, Yumei Zhao, Yujin Su, Yazhuo Zhang
BACKGROUND Potassium aspartate (PA), as an electrolyte supplement, is widely used in clinical practice. In our previous study, we found PA had neuroprotective effects against apoptosis after cerebral ischemia/reperfusion in rats. In this study, we examine whether PA has protective effects on traumatic brain injury (TBI). MATERIAL AND METHODS TBI was induced by controlled cortical impact (CCI) in rats. Vehicle treatment (control) or PA treatment was administered intraperitoneally at 30 minutes after CCI. The modified neurological severity score (mNSS) and cortical lesion volume were examined...
December 13, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27909732/early-vegf-inhibition-attenuates-blood-brain-barrier-disruption-in-ischemic-rat-brains-by-regulating-the-expression-of-mmps
#12
Hai-Tao Zhang, Ping Zhang, Yi Gao, Chen-Long Li, Hong-Jun Wang, Ling-Chao Chen, Yan Feng, Rui-Yan Li, Yong-Li Li, Chuan-Lu Jiang
Vascular endothelial growth factor (VEGF) inhibition has been demonstrated to be an effective strategy in preserving the integrity of the blood-brain barrier (BBB) in patients with acute ischemic stroke. Loss of the BBB is the key event associated with morbidity and mortality in these patients. However, the underlying mechanisms remain poorly understood. In the present study, the effects of VEGF inhibition and the possible mechanism that underlies acute cerebral ischemia in rats was investigated. Following the induction of transient middle cerebral artery occlusion for a 90‑min period, either an anti‑VEGF neutralizing antibody (RB‑222; 5 or 10 µg), or IgG (control), was administered by intracerebroventricular injection at 1 h following reperfusion...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27906703/left-ventricular-ejection-fraction-and-mortality-in-patients-with-st-elevation-myocardial-infarction-and-bundle-branch-block
#13
M Yldau van der Ende, Minke H T Hartman, Tom Hendriks, Hindrik W van der Werf, Erik Lipsic, Pim van der Harst
BACKGROUND: The aim of our study is to assess the effect of bundle branch block (BBB) on mortality and left ventricular ejection fraction (LVEF) in ST-elevation myocardial infarction (STEMI) patients treated in the current era of percutaneous reperfusion therapy. PATIENTS AND METHODS: In this retrospective cohort study, a total of 1123 STEMI patients treated in the University Medical Center Groningen from January 2011 until May 2013 were included. The follow-up duration was 2-4 years...
November 30, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27887979/protective-effect-of-nicotinamide-adenine-dinucleotide-nad-against-spinal-cord-ischemia-reperfusion-injury-via-reducing-oxidative-stress-induced-neuronal-apoptosis
#14
Lei Xie, Zhenfei Wang, Changwei Li, Kai Yang, Yu Liang
As previous studies demonstrate that oxidative stress and apoptosis play crucial roles in ischemic pathogenesis and nicotinamide adenine dinucleotide (NAD(+)) treatment attenuates oxidative stress-induced cell death among primary neurons and astrocytes as well as significantly reduce cerebral ischemic injury in rats. We used a spinal cord ischemia injury (SCII) model in rats to verify our hypothesis that NAD(+) could ameliorate oxidative stress-induced neuronal apoptosis. Adult male rats were subjected to transient spinal cord ischemia for 60min, and different doses of NAD(+) were administered intraperitoneally immediately after the start of reperfusion...
February 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27880979/low-dose-lipopolysaccharide-causes-biliary-injury-by-blood-biliary-barrier-impairment-in-a-rat-hepatic-ischemia-reperfusion-model
#15
Janske Reiling, Kim R Bridle, Marion Gijbels, Frank G Schaap, Lesley Jaskowski, Nishreen Santrampurwala, Laurence J Britton, Catherine M Campbell, Steven W M Olde Damink, Darrell H G Crawford, Cornelius H C Dejong, Jonathan Fawcett
This study explored whether bacterial endotoxins, in the form of lipopolysaccharides (LPS), could have an injurious effect on the biliary tract in conjunction with ischemia. A total of 64 rats were randomly assigned to 4 groups: sham operation (sham group), 1 mg/kg LPS intraperitoneal (LPS group), hepatic ischemia/reperfusion (IR; IR group), and IR combined with LPS (IR+LPS group). Following 1 or 6 hours of reperfusion, serum liver tests, bile duct histology, immunofluorescence microscopy (zonula occludens-1 [ZO-1]), bile composition (bile salts, phospholipids, lactate dehydrogenase), hepatic gene expression (bile salt transporters and inflammatory mediators), as well as serum and biliary cytokine concentrations were quantified and compared between the study groups...
February 2017: Liver Transplantation
https://www.readbyqxmd.com/read/27837475/pericytes-in-brain-injury-and-repair-after-ischemic-stroke
#16
REVIEW
Wei Cai, Huan Liu, Jingyan Zhao, Lily Y Chen, Jun Chen, Zhengqi Lu, Xiaoming Hu
Pericytes are functional components of the neurovascular unit (NVU). They provide support to other NVU components and maintain normal physiological functions of the blood-brain barrier (BBB). The brain ischemia and reperfusion result in pathological alterations in pericytes. The intimate anatomical and functional interactions between pericytes and other NVU components play pivotal roles in the progression of stroke pathology. In this review, we depict the biology and functions of pericytes in the normal brain and discuss their effects in brain injury and repair after ischemia/reperfusion...
April 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/27818230/effect-of-ppar-%C3%AE-%C3%AE-agonist-gw0742-treatment-in-the-acute-phase-response-and-blood-brain-barrier-permeability-following-brain-injury
#17
Khouloud Chehaibi, Laura le Maire, Sarah Bradoni, Joan Carles Escola, Francisco Blanco-Vaca, Mohamed Naceur Slimane
The systemic response to ischemic stroke is associated with the hepatic acute phase response (APR) that modulates leukocytes recruitment to the injured brain. The inappropriate recruitment of leukocytes to the brain parenchyma can result in blood-brain barrier (BBB) breakdown. Emerging data suggest that peroxisome proliferator-activated receptor beta/delta (PPAR-β/δ) activation has a potential neuroprotective role in ischemic stroke. However, mechanisms of PPAR-β/δ mediated protection in ischemic insults remain unclear...
October 18, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27818208/effect-of-enriched-environment-on-angiogenesis-and-neurological-functions-in-rats-with-focal-cerebral-ischemia
#18
Xin Zhang, Xiu-Ping Chen, Jun-Bin Lin, Yu Xiong, Wei-Jing Liao, Qi Wan
The purpose of this study was to investigate the effect of enriched environment (EE) on cerebral angiogenesis after ischemia-reperfusion injury. Middle cerebral artery occlusion (MCAO) followed by reperfusion was performed in rats to set up an animal model of ischemia-reperfusion injury. In a set of behavioral tests, we demonstrated that the animals in the IEE (ischemia + enriched environment) group exhibited significantly improved neurological functions compared to those in the standard housing condition group...
January 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27697546/dysfunction-of-the-neurovascular-unit-in-ischemic-stroke-and-neurodegenerative-diseases-an-aging-effect
#19
Wei Cai, Kai Zhang, Peiying Li, Ling Zhu, Jing Xu, Boyu Yang, Xiaoming Hu, Zhengqi Lu, Jun Chen
Current understanding on the mechanisms of brain injury and neurodegeneration highlights an appreciation of multicellular interactions within the neurovascular unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, neuronal cell death or degeneration, glial reaction, and immune cell infiltration. Aging is an important factor that influences the integrity of the NVU. The age-related physiological or pathological changes in the cellular components of the NVU have been shown to increase the vulnerability of the NVU to ischemia/reperfusion injury or neurodegeneration, and to result in deteriorated brain damage...
September 30, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27696223/nrf2-a-promising-therapeutic-target-for-defensing-against-oxidative-stress-in-stroke
#20
Rongrong Zhang, Mengxue Xu, Yu Wang, Fei Xie, Gang Zhang, Xinyue Qin
Stroke is one of the leading causes of death and disability in the world. Oxidative stress, which refers to an excessive generation of reactive oxygen species (ROS), plays a key role in the pathological process of stroke. Excessive ROS production contributes to brain ischemia/reperfusion injury through many mechanisms including BBB disruption, inflammation, apoptosis, and cellular necrosis. Nuclear factor-E2-related factor 2 (Nrf2) is one of the critical regulators of endogenous antioxidant defense, which promote the transcription of a wide variety of antioxidant genes...
September 30, 2016: Molecular Neurobiology
keyword
keyword
110149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"