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https://www.readbyqxmd.com/read/27909732/early-vegf-inhibition-attenuates-blood-brain-barrier-disruption-in-ischemic-rat-brains-by-regulating-the-expression-of-mmps
#1
Hai-Tao Zhang, Ping Zhang, Yi Gao, Chen-Long Li, Hong-Jun Wang, Ling-Chao Chen, Yan Feng, Rui-Yan Li, Yong-Li Li, Chuan-Lu Jiang
Vascular endothelial growth factor (VEGF) inhibition has been demonstrated to be an effective strategy in preserving the integrity of the blood-brain barrier (BBB) in patients with acute ischemic stroke. Loss of the BBB is the key event associated with morbidity and mortality in these patients. However, the underlying mechanisms remain poorly understood. In the present study, the effects of VEGF inhibition and the possible mechanism that underlies acute cerebral ischemia in rats was investigated. Following the induction of transient middle cerebral artery occlusion for a 90‑min period, either an anti‑VEGF neutralizing antibody (RB‑222; 5 or 10 µg), or IgG (control), was administered by intracerebroventricular injection at 1 h following reperfusion...
November 29, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27906703/left-ventricular-ejection-fraction-and-mortality-in-patients-with-st-elevation-myocardial-infarction-and-bundle-branch-block
#2
M Yldau van der Ende, Minke H T Hartman, Tom Hendriks, Hindrik W van der Werf, Erik Lipsic, Pim van der Harst
BACKGROUND: The aim of our study is to assess the effect of bundle branch block (BBB) on mortality and left ventricular ejection fraction (LVEF) in ST-elevation myocardial infarction (STEMI) patients treated in the current era of percutaneous reperfusion therapy. PATIENTS AND METHODS: In this retrospective cohort study, a total of 1123 STEMI patients treated in the University Medical Center Groningen from January 2011 until May 2013 were included. The follow-up duration was 2-4 years...
November 30, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27887979/protective-effect-of-nicotinamide-adenine-dinucleotide-nad-against-spinal-cord-ischemia-reperfusion-injury-via-reducing-oxidative-stress-induced-neuronal-apoptosis
#3
Lei Xie, Zhenfei Wang, Changwei Li, Kai Yang, Yu Liang
As previous studies demonstrate that oxidative stress and apoptosis play crucial roles in ischemic pathogenesis and nicotinamide adenine dinucleotide (NAD(+)) treatment attenuates oxidative stress-induced cell death among primary neurons and astrocytes as well as significantly reduce cerebral ischemic injury in rats. We used a spinal cord ischemia injury (SCII) model in rats to verify our hypothesis that NAD(+) could ameliorate oxidative stress-induced neuronal apoptosis. Adult male rats were subjected to transient spinal cord ischemia for 60min, and different doses of NAD(+) were administered intraperitoneally immediately after the start of reperfusion...
November 23, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27880979/low-dose-lipopolysaccharide-causes-biliary-injury-by-blood-biliary-barrier-impairment-in-a-rat-hepatic-ischemia-reperfusion-model
#4
J Reiling, K R Bridle, M Gijbels, F G Schaap, L Jaskowski, N Santrampurwala, L J Britton, C M Campbell, S W M Olde Damink, D H G Crawford, C H C Dejong, J Fawcett
INTRODUCTION: This study explored whether bacterial endotoxins, in the form of lipopolysaccharides (LPS), could have an injurious effect on the biliary tract in conjunction with ischemia. METHOD: Sixty-four rats were randomly assigned to four groups: sham operation (sham), 1mg/kg LPS i.p. (LPS), hepatic ischemia reperfusion (IR), and IR combined with LPS (IR+LPS). Following 1 or 6 hours of reperfusion, serum liver tests, bile duct histology, immunofluorescence microscopy (zonula occludens-1), bile composition (bile salts, phospholipids, lactate dehydrogenase), hepatic gene expression (bile salt transporters and inflammatory mediators) as well as serum and biliary cytokine concentrations were quantified and compared between the study groups...
November 23, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27837475/pericytes-in-brain-injury-and-repair-after-ischemic-stroke
#5
REVIEW
Wei Cai, Huan Liu, Jingyan Zhao, Lily Y Chen, Jun Chen, Zhengqi Lu, Xiaoming Hu
Pericytes are functional components of the neurovascular unit (NVU). They provide support to other NVU components and maintain normal physiological functions of the blood-brain barrier (BBB). The brain ischemia and reperfusion result in pathological alterations in pericytes. The intimate anatomical and functional interactions between pericytes and other NVU components play pivotal roles in the progression of stroke pathology. In this review, we depict the biology and functions of pericytes in the normal brain and discuss their effects in brain injury and repair after ischemia/reperfusion...
November 12, 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/27818230/effect-of-ppar-%C3%AE-%C3%AE-agonist-gw0742-treatment-in-the-acute-phase-response-and-blood-brain-barrier-permeability-following-brain-injury
#6
Khouloud Chehaibi, Laura le Maire, Sarah Bradoni, Joan Carles Escola, Francisco Blanco-Vaca, Mohamed Naceur Slimane
The systemic response to ischemic stroke is associated with the hepatic acute phase response (APR) that modulates leukocytes recruitment to the injured brain. The inappropriate recruitment of leukocytes to the brain parenchyma can result in blood-brain barrier (BBB) breakdown. Emerging data suggest that peroxisome proliferator-activated receptor beta/delta (PPAR-β/δ) activation has a potential neuroprotective role in ischemic stroke. However, mechanisms of PPAR-β/δ mediated protection in ischemic insults remain unclear...
October 18, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27818208/effect-of-enriched-environment-on-angiogenesis-and-neurological-functions-in-rats-with-focal-cerebral-ischemia
#7
Xin Zhang, Xiu-Ping Chen, Jun-Bin Lin, Yu Xiong, Wei-Jing Liao, Qi Wan
The purpose of this study was to investigate the effect of enriched environment (EE) on cerebral angiogenesis after ischemia-reperfusion injury. Middle cerebral artery occlusion (MCAO) followed by reperfusion was performed in rats to set up an animal model of ischemia-reperfusion injury. In a set of behavioral tests, we demonstrated that the animals in the EE group exhibited significantly improved neurological functions compared to those in the standard housing condition group. In consistent with the functional tests, smaller infarction volumes were observed in the animals of EE group...
November 3, 2016: Brain Research
https://www.readbyqxmd.com/read/27697546/dysfunction-of-the-neurovascular-unit-in-ischemic-stroke-and-neurodegenerative-diseases-an-aging-effect
#8
Wei Cai, Kai Zhang, Peiying Li, Ling Zhu, Jing Xu, Boyu Yang, Xiaoming Hu, Zhengqi Lu, Jun Chen
Current understanding on the mechanisms of brain injury and neurodegeneration highlights an appreciation of multicellular interactions within the neurovascular unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, neuronal cell death or degeneration, glial reaction, and immune cell infiltration. Aging is an important factor that influences the integrity of the NVU. The age-related physiological or pathological changes in the cellular components of the NVU have been shown to increase the vulnerability of the NVU to ischemia/reperfusion injury or neurodegeneration, and to result in deteriorated brain damage...
September 30, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27696223/nrf2-a-promising-therapeutic-target-for-defensing-against-oxidative-stress-in-stroke
#9
Rongrong Zhang, Mengxue Xu, Yu Wang, Fei Xie, Gang Zhang, Xinyue Qin
Stroke is one of the leading causes of death and disability in the world. Oxidative stress, which refers to an excessive generation of reactive oxygen species (ROS), plays a key role in the pathological process of stroke. Excessive ROS production contributes to brain ischemia/reperfusion injury through many mechanisms including BBB disruption, inflammation, apoptosis, and cellular necrosis. Nuclear factor-E2-related factor 2 (Nrf2) is one of the critical regulators of endogenous antioxidant defense, which promote the transcription of a wide variety of antioxidant genes...
September 30, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27616018/nanoliposome-containing-cyclosporin-a-reduced-neuroinflammation-responses-and-improved-neurological-activities-in-cerebral-ischemia-reperfusion-in-rat
#10
Alireza Partoazar, Sanaz Nasoohi, Sayed Mehdi Rezayat, Kambiz Gilani, Shahram Ejtemaei Mehr, Amir Amani, Nastaran Rahimi, Ahmad Reza Dehpour
Cyclosporin A (CsA) is known as a neuroprotective agent against cerebral ischemia/reperfusion (I/R) in animal models. However, the significant therapeutic effects of CsA have been observed in high systemic doses or manipulating the blood brain barrier (BBB), resulting in systemic side effects and toxicity. Since the liposome nanocarries have been developed for efficient delivery of peptide and proteins, liposomal CsA (Lipo-CsA) could improve cerebral (I/R) injuries. In this study, the liposomal CsA formulation (CsA at dose of 2...
September 12, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27609227/salvianolic-acid-a-alleviates-ischemic-brain-injury-through-the-inhibition-of-inflammation-and-apoptosis-and-the-promotion-of-neurogenesis-in-mice
#11
Mei-Yin Chien, Cheng-Hung Chuang, Chang-Ming Chern, Kou-Tong Liou, Der-Zen Liu, Yu-Chang Hou, Yuh-Chiang Shen
Salvianolic acid A (SalA), a chemical type of caffeic acid trimer, has drawn great attention for its potent bioactivities against ischemia-induced injury both in vitro and in vivo. In this study, we evaluated SalA's protective effects against acute ischemic stroke by inducing middle cerebral artery occlusion/reperfusion (MCAO) injuries in mice. Treatment of the mice with SalA (50 and 100μg/kg, i.v.) at 2h after MCAO enhanced their survival rate, improved their moving activity, and ameliorated the severity of brain infarction and apoptosis seen in the mice by diminishing pathological changes such as the extensive breakdown of the blood-brain barrier (BBB), nitrosative stress, and the activation of an inflammatory transcriptional factor p65 nuclear factor-kappa B (NF-κB) and a pro-apoptotic kinase p25/Cdk5...
September 5, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27589720/ruscogenin-attenuates-cerebral-ischemia-induced-blood-brain-barrier-dysfunction-by-suppressing-txnip-nlrp3-inflammasome-activation-and-the-mapk-pathway
#12
Guosheng Cao, Nan Jiang, Yang Hu, Yuanyuan Zhang, Guangyun Wang, Mingzhu Yin, Xiaonan Ma, Kecheng Zhou, Jin Qi, Boyang Yu, Junping Kou
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood-brain barrier (BBB) dysfunction after stroke remains unclear. This study aimed to investigate the effects of ruscogenin on BBB dysfunction and the underlying mechanisms in middle cerebral artery occlusion/reperfusion (MCAO/R)-injured mice and oxygen-glucose deprivation/reoxygenation (OGD/R)-injured mouse brain microvascular endothelial cells (bEnd...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27587960/assessment-of-blood-brain-barrier-permeability-by-dynamic-contrast-enhanced-mri-in-transient-middle-cerebral-artery-occlusion-model-after-localized-brain-cooling-in-rats
#13
Eun Soo Kim, Seung-Koo Lee, Mi Jung Kwon, Phil Hye Lee, Young-Su Ju, Dae Young Yoon, Hye Jeong Kim, Kwan Seop Lee
OBJECTIVE: The purpose of this study was to evaluate the effects of localized brain cooling on blood-brain barrier (BBB) permeability following transient middle cerebral artery occlusion (tMCAO) in rats, by using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS: Thirty rats were divided into 3 groups of 10 rats each: control group, localized cold-saline (20℃) infusion group, and localized warm-saline (37℃) infusion group. The left middle cerebral artery (MCA) was occluded for 1 hour in anesthetized rats, followed by 3 hours of reperfusion...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27587462/hydroquinone-strongly-alleviates-focal-ischemic-brain-injury-via-blockage-of-blood-brain-barrier-disruption-in-rats
#14
Joon Ha Park, Ki-Yeon Yoo, In Hye Kim, Jeong-Hwi Cho, Jae-Chul Lee, Ji Hyeon Ahn, Hyun Jin Tae, Bing Chun Yan, Dae Won Kim, Ok Kyu Park, Seung-Hae Kwon, Song Her, Jin Su Kim, Jung Hoon Choi, Choong Hyun Lee, In Koo Hwang, Jae Youl Cho, Jun Hwi Cho, Young-Guen Kwon, Sungwoo Ryoo, Young-Myeong Kim, Moo-Ho Won, Il Jun Kang
Hydroquinone (HQ), a major benzene metabolite, occurs naturally in various plants and is manufactured for commercial use. Although HQ displays various biological effects, its neuroprotective effects following ischemic insults have not been investigated. In this study, we first examined neuroprotective effects of HQ in a rat model of transient focal cerebral ischemia. Animals were subjected to transient middle cerebral artery occlusion for 120 min. HQ (50 or 100 mg/kg) or vehicle was intraperitoneally administered once at 30 min after ischemia-reperfusion...
August 31, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27566245/the-glucagon-like-peptide-1-receptor-agonist-exendin-4-ameliorates-warfarin-associated-hemorrhagic-transformation-after-cerebral-ischemia
#15
Fangzhe Chen, Weifeng Wang, Hongyan Ding, Qi Yang, Qiang Dong, Mei Cui
BACKGROUND: As the number of patients with cardioembolic ischemic stroke is predicted to be double by 2030, increased burden of warfarin-associated hemorrhagic transformation (HT) after cerebral ischemia is an expected consequence. However, thus far, no effective treatment strategy is available for HT prevention in routine clinical practice. While the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) is known to protect against oxidative stress and neuronal cell death caused by ischemic brain damage, its effect on preventing warfarin-associated HT after cerebral ischemia is yet unknown...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27560521/increased-plasma-matrix-metalloproteinase-9-levels-contribute-to-intracerebral-hemorrhage-during-thrombolysis-after-concomitant-stroke-and-influenza-infection
#16
Sajjad Muhammad, Oliver Planz, Markus Schwaninger
BACKGROUND: Thrombolysis is the only approved therapy for acute stroke. However, life-threatening complications such as intracerebral hemorrhage (ICH) can develop after intravenous administration of tissue plasminogen activator (tPA). Both infection and thrombolysis during cerebral ischemia disrupt the blood-brain barrier (BBB). tPA can induce matrix metalloproteinase-9 (MMP-9), which is known to be involved in BBB disruption. However, it has still not been investigated whether preexisting influenza virus infection during thrombolysis after acute stroke affects systemic levels of MMP-9 and its inhibitor TIMP-1 and whether increased systemic MMP-9 levels affect ICH...
2016: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/27538649/xenon-delayed-postconditioning-attenuates-spinal-cord-ischemia-reperfusion-injury-through-activation-akt-and-erk-signaling-pathways-in-rats
#17
Shiyao Liu, Yanwei Yang, Mu Jin, Siyu Hou, Xiuhua Dong, Jiakai Lu, Weiping Cheng
Previous studies have shown that xenon-delayed postconditioning for up to 2h after reperfusion provides protection against spinal cord ischemia/reperfusion (I/R) injury in rats. This study was designed to determine the roles of phosphatidylinositol 3-kinase (PI3K)-Akt and extracellular signal-regulated kinase (ERK) in this neuroprotection. The rats were randomly assigned to the following nine groups (n=16∗9): 1) I/R+N2 group, 2) I/R+Xe group, 3) I/R+PD98059+N2 group (ERK blocking agent), 4) I/R+wortmannin+N2 group (PI3K-Akt blocking agent), 5) I/R+PD98059+Xe group, 6) I/R+wortmannin+Xe group, 7) I/R+DMSO+Xe group (dimethyl sulfoxide, vehicle control), 8) I/R+DMSO+N2 group, and 9) sham group (no spinal cord ischemia and no xenon)...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27476927/neuroprotective-effects-of-pregabalin-against-spinal-cord-ischemia-reperfusion-injury-in-rats
#18
Burak Kazanci, Selcuk Ozdogan, Ramazan Kahveci, Emre Cemal Gokce, Kazim Yigitkanli, Aysun Gokce, Bulent Erdogan
AIM: We aimed in this study to evaluate the effect of pregabalin pretreatment on spinal cord ischemia-reperfusion(I/R) injury and compare it with methylprednisolone(MP). MATERIAL AND METHODS: Rats were randomized into four groups as follow: group 1 (sham)(n=8), group 2 (ischemia only)(n=8), group 3 (30 mg/kg pregabalin)(n=8), and group 4 (30 mg/kg methylprednisolone)(n=8). Laparotomy was performed without aortic clamp in the sham group. All animals were killed at 24 h after surgery...
April 27, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27462115/identification-of-reversible-disruption-of-the-human-blood-brain-barrier-following-acute-ischemia
#19
Alexis N Simpkins, Christian Dias, Richard Leigh
BACKGROUND AND PURPOSE: Animal models of acute cerebral ischemia have demonstrated that diffuse blood-brain barrier (BBB) disruption can be reversible after early reperfusion. However, irreversible, focal BBB disruption in humans is associated with hemorrhagic transformation in patients receiving intravenous thrombolytic therapy. The goal of this study was to use a magnetic resonance imaging biomarker of BBB permeability to differentiate these 2 forms of BBB disruption. METHODS: Acute stroke patients imaged with magnetic resonance imaging before, 2 hours after, and 24 hours after treatment with intravenous tissue-type plasminogen activator were included...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27425889/role-of-hypoxia-inducible-factor-1-in-hyperglycemia-exacerbated-blood-brain-barrier-disruption-in-ischemic-stroke
#20
Ziyan Zhang, Jingqi Yan, Honglian Shi
Diabetes is a major stroke risk factor and is associated with poor functional recovery after stroke. Accumulating evidence indicates that the worsened outcomes may be due to hyperglycemia-induced cerebral vascular complications, especially disruption of the blood-brain barrier (BBB). The present study tested a hypothesis that the activation of hypoxia inducible factor-1 (HIF-1) was involved in hyperglycemia-aggravated BBB disruption in an ischemic stroke model. Non-diabetic control and Streptozotocin-induced type I diabetic mice were subjected to 90min transient middle cerebral artery occlusion (MCAO) followed by reperfusion...
November 2016: Neurobiology of Disease
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