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https://www.readbyqxmd.com/read/29291404/ulinastatin-protects-brain-against-cerebral-ischemia-reperfusion-injury-through-inhibiting-mmp-9-and-alleviating-loss-of-zo-1-and-occludin-proteins-in-mice
#1
Xiao-Fang Li, Xiang-Jian Zhang, Cong Zhang, Li-Na Wang, Yao-Ru Li, Ye Zhang, Ting-Ting He, Xing-Yuan Zhu, Li-Li Cui, Bu-Lang Gao
BACKGROUND: The effects of Ulinastatin (UTI) on the blood-brain barrier (BBB) in the acute phase of cerebral ischemia/reperfusion (I/R) are not clear. This study was to investigate the potential protective effects of UTI on the BBB and the underlying mechanisms. METHODS: Male CD-1 mice were subjected to transient middle cerebral artery occlusion (tMCAO) and randomly assigned to four groups: Sham (sham-operated), tMCAO (tMCAO+0.9% saline), UTI-L (tMCAO+UTI 1500U/100g) and UTI-H (tMCAO+UTI 3000U/100g) group...
December 29, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29291393/patchouli-alcohol-protects-against-ischemia-reperfusion-induced-brain-injury-via-inhibiting-neuroinflammation-in-normal-and-obese-mice
#2
Li-Li Wei, Yong Chen, Qiong-Yang Yu, Yuhui Wang, George Liu
Almost all of the candidate drugs for ischemic stroke failed to be translated from bench to beside. One important reason is that animals used in experimental studies cannot mimic ischemic patients due to lack of comorbidities like hypertension, diabetes and obesity. Therefore, it is better to test candidate drugs not only in normal animals but also in animals with comorbidities. Patchouli alcohol (PA), a natural tricyclic sesquiterpene in the traditional Chinese herb Pogostemonisherba, is well recognized for its anti-inflammation function in various inflammatory diseases...
December 29, 2017: Brain Research
https://www.readbyqxmd.com/read/29275501/baicalin-attenuates-blood-brain-barrier-disruption-and-hemorrhagic-transformation-and-improves-neurological-outcome-in-ischemic-stroke-rats-with-delayed-t-pa-treatment-involvement-of-onoo-mmp-9-pathway
#3
Hansen Chen, Binghe Guan, Xi Chen, Xingmiao Chen, Caiming Li, Jinhua Qiu, Dan Yang, Ke Jian Liu, Suhua Qi, Jiangang Shen
Tissue plasminogen activator (t-PA) has a restrictive therapeutic window within 4.5 h after ischemic stroke with the risk of hemorrhagic transformation (HT) and neurotoxicity when it is used beyond the time window. In the present study, we tested the hypothesis that baicalin, an active compound of medicinal plant, could attenuate HT in cerebral ischemia stroke with delayed t-PA treatment. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 4.5 h and then continuously received t-PA infusion (10 mg/kg) for 0...
December 23, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29228445/the-protective-effect-and-its-mechanism-of-3-n-butylphthalide-pretreatment-on-cerebral-ischemia-reperfusion-injury-in-rats
#4
R-Y Yan, S-J Wang, G-T Yao, Z-G Liu, N Xiao
OBJECTIVE: To investigate the potential effect of 3-n-butylphthalide (NBP) pretreatment on the cerebral ischemia/reperfusion injury in rats and the relevant mechanism. MATERIALS AND METHODS: A total of 90 rats was divided into three groups: Sham operation group (Sham group), ischemia-reperfusion group (I-R group), and NBP pretreatment group (NBP group 75 mg·kg-1·d-1 gavage). Pre-treatment was given once a day within 1 week before establishing the rat model of cerebral ischemia-reperfusion injury...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29202406/pyrano-3-2-a-carbazole-alkaloids-as-effective-agents-against-ischemic-stroke-in%C3%A2-vitro-and-in%C3%A2-vivo
#5
Yingda Zang, Xiuyun Song, Chuangjun Li, Jie Ma, Shifeng Chu, Dandan Liu, Qian Ren, Yan Li, Naihong Chen, Dongming Zhang
A series of pyrano[3,2-a]carbazole alkaloids were designed and synthesized as analogues of Claulansine F (Clau F, 10a) isolated from Clausena lansium. Some of compounds showed strong neuroprotective effects and were promising agents against ischemic stroke. Among these compounds, 7c was the most active in inhibiting the programmed death of PC12 cells and primary cortical neurons. This compound induced neuroprotection following ischemic reperfusion and decreased neurological deficit scores in treated animals...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29195783/platelet-glycoprotein-receptor-ib-blockade-ameliorates-experimental-cerebral-ischemia-reperfusion-injury-by-strengthening-the-blood-brain-barrier-function-and-anti-thrombo-inflammatory-property
#6
Chunyan Chen, Tingting Li, Yuchen Zhao, Yinfeng Qian, Xiaoyi Li, Xiangrong Dai, Dake Huang, Tanzhong Pan, Lanlan Zhou
Blood-brain barrier (BBB) disruption, thrombus formation and immune-mediated inflammation are important steps in the pathophysiology of cerebral ischemia-reperfusion injury but are still inaccessible to therapeutic interventions. Recent studies have provided increasing evidence that blocking of platelet glycoprotein (GP) receptor Ib might represent a novel target in treating acute ischemic stroke. This research was conducted to explore the therapeutic efficacy and potential mechanisms of GPIba inhibitor (anfibatide) in a model of brain ischemia-reperfusion injury in mice...
November 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29157263/ldl-receptor-blockade-reduces-mortality-in-a-mouse-model-of-ischaemic-stroke-without-improving-tissue-type-plasminogen-activator-induced-brain-haemorrhage-towards-pre-clinical-simulation-of-symptomatic-ich
#7
Be'eri Niego, Brad R S Broughton, Heidi Ho, Christopher G Sobey, Robert L Medcalf
BACKGROUND: Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstacle for a broader uptake of this beneficial treatment. rt-PA also undermines cerebral vasculature stability in a multimodal process which involves engagement with LDL receptor-related protein 1 (LRP-1), potentially underlying the development of sICH...
November 21, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29151151/long-term-treatment-of-diabetic-rats-with-vanadyl-sulfate-or-insulin-attenuate-acute-focal-cerebral-ischemia-reperfusion-injury-via-their-antiglycemic-effect
#8
Hossein Ahmadi-Eslamloo, Gholam Abbas Dehghani, Seyed Mostafa Shid Moosavi
It is well-known that patients with diabetes mellitus have worse clinical outcomes following acute ischemic stroke. The intensifying effects of diabetes on ischemic brain injury have been shown to be mostly due to hyperglycemia, rather than the lack of insulin direct effects on brain. It is also well-approved that vanadium compounds have insulin-like and anti-diabetic effects, and the present study was designed to compare the protective effects of diabetes treatment with vanadium or insulin on ischemic/reperfused brain injury...
November 19, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28931617/normobaric-hyperoxia-reduces-blood-occludin-fragments-in-rats-and-patients-with-acute-ischemic-stroke
#9
Shuhai Shi, Zhifeng Qi, Qingfeng Ma, Rong Pan, Graham S Timmins, Yongmei Zhao, Wenjuan Shi, Yunzhou Zhang, Xunming Ji, Ke Jian Liu
BACKGROUND AND PURPOSE: Damage of the blood-brain barrier (BBB) increases the incidence of neurovascular complications, especially for cerebral hemorrhage after tPA (tissue-type plasminogen activator) therapy. Currently, there is no effective method to evaluate the extent of BBB damage to guide tPA use. Herein, we investigated whether blood levels of tight junction proteins could serve as biomarker of BBB damages in acute ischemic stroke (AIS) in both rats and patients. We examined whether this biomarker could reflect the extent of BBB permeability during cerebral ischemia/reperfusion and the effects of normobaric hyperoxia (NBO) on BBB damage...
October 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28874782/dihydrocapsaicin-attenuates-blood-brain-barrier-and-cerebral-damage-in-focal-cerebral-ischemia-reperfusion-via-oxidative-stress-and-inflammatory
#10
Adchara Janyou, Piyawadee Wicha, Jinatta Jittiwat, Apichart Suksamrarn, Chainarong Tocharus, Jiraporn Tocharus
This study investigated the effect of dihydrocapsaicin (DHC) on cerebral and blood brain barrier (BBB) damage in cerebral ischemia and reperfusion (I/R) models. The models were induced by middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion. The rats were divided into five groups: sham, or control group; vehicle group; and 2.5 mg/kg, 5 mg/kg, and 10 mg/kg BW DHC-treated I/R groups. After 24 h of reperfusion, we found that DHC significantly reduced the area of infarction, morphology changes in the neuronal cells including apoptotic cell death, and also decreased the BBB damage via reducing Evan Blue leakage, water content, and ultrastructure changes, in addition to increasing the tight junction (TJ) protein expression...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28864200/vascular-expression-of-angiopoietin1-%C3%AE-5%C3%AE-1-integrin-and-tight-junction-proteins-is-tightly-regulated-during-vascular-remodeling-in-the-post-ischemic-brain
#11
Jialan Sun, Liming Yu, Shu Huang, Xiaoyin Lai, Richard Milner, Longxuan Li
The post-stroke angiogenic response is accompanied by changes of tight junctions (TJs) of the blood-brain barrier (BBB). However, the precise dynamic change of TJ proteins (TJPs) in the different stages of stroke-induced vascular remodeling and the molecules mediating these processes have yet to be fully defined. To investigate the temporal relationship between changes in TJPs, the pro-angiogenic factor α5β1 integrin and the anti-permeability factor Ang1 in cerebral vessels following cerebral ischemic stroke, male C57Bl/6 mice were subject to 90min of ischemia by temporary occlusion of the middle cerebral artery followed by reperfusion and their brains analyzed 0, 1, 2, 4, 7 and 14days post-ischemia...
August 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28856409/reperfusion-facilitates-reversible-disruption-of-the-human-blood-brain-barrier-following-acute-ischaemic-stroke
#12
Chang Liu, Sheng Zhang, Shenqiang Yan, Ruiting Zhang, Feina Shi, Xinfa Ding, Mark Parsons, Min Lou
OBJECTIVES: We aimed to detect early changes of the blood-brain barrier permeability (BBBP) in acute ischaemic stroke (AIS), with or without reperfusion, and find out whether BBBP can predict clinical outcomes. METHODS: Consecutive AIS patients imaged with computed tomographic perfusion (CTP) before and 24 h after treatment were included. The relative permeability-surface area product (rPS) was calculated within the hypoperfused region (rPShypo-i), non-hypoperfused region of ischaemic hemisphere (rPSnonhypo-i) and their contralateral mirror regions (rPShypo-c and rPSnonhypo-c)...
August 30, 2017: European Radiology
https://www.readbyqxmd.com/read/28854286/therapeutic-time-window-for-conivaptan-treatment-against-stroke-evoked-brain-edema-and-blood-brain-barrier-disruption-in-mice
#13
Emil Zeynalov, Susan M Jones, J Paul Elliott
BACKGROUND: Ischemic stroke is often complicated by brain edema, disruption of blood-brain barrier (BBB), and uncontrolled release of arginine-vasopressin (AVP). Conivaptan, a V1a and V2 receptor antagonist, reduces brain edema and minimizes damage to the blood-brain barrier after stroke. Most stroke patients do not receive treatment immediately after the onset of brain ischemia. Delays in therapy initiation may worsen stroke outcomes. Therefore, we designed a translational study to explore the therapeutic time window for conivaptan administration...
2017: PloS One
https://www.readbyqxmd.com/read/28843994/nrg-1%C3%AE-exerts-neuroprotective-effects-against-ischemia-reperfusion-induced-injury-in-rats-through-the-jnk-signaling-pathway
#14
Yaqing Ji, Lei Teng, Rui Zhang, Jinping Sun, Yunliang Guo
BACKGROUND: Neuregulin-1β (NRG-1β) has great potential to be developed into therapeutics for neuroprotection. The aim of the current study was to analyze the effects and possible signaling pathway of NRG-1β on brain tissues in a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R). METHODS: In order to observe the protective effect of NRG-1β on MCAO/R, the neurological deficit and infarct volume were measured using a modified neurological severity score (mNSS) test and by triphenyl tetrazolium chloride (TTC) staining...
August 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28812311/nad-replenishment-with-nicotinamide-mononucleotide-protects-blood-brain-barrier-integrity-and-attenuates-delayed-tissue-plasminogen-activator-induced-haemorrhagic-transformation-after-cerebral-ischaemia
#15
Chun-Chun Wei, Yuan-Yuan Kong, Xia Hua, Guo-Qiang Li, Si-Li Zheng, Ming-He Cheng, Pei Wang, Chao-Yu Miao
BACKGROUND AND PURPOSE: Tissue plasminogen activator (tPA) is the only approved pharmacological therapy for acute brain ischaemia; however, a major limitation of tPA is the haemorrhagic transformation that follows tPA treatment. Here, we determined whether nicotinamide mononucleotide (NMN), a key intermediate of nicotinamide adenine dinucleotide biosynthesis, affects tPA-induced haemorrhagic transformation. EXPERIMENTAL APPROACH: Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h...
November 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28780000/systemic-infusions-of-anti-interleukin-1%C3%AE-neutralizing-antibodies-reduce-short-term-brain-injury-after-cerebral-ischemia-in-the-ovine-fetus
#16
Xiaodi Chen, Virginia Hovanesian, Syed Naqvi, Yow-Pin Lim, Richard Tucker, John E Donahue, Edward G Stopa, Barbara S Stonestreet
Perinatal hypoxic-ischemic reperfusion (I/R)-related brain injury is a leading cause of neurologic morbidity and life-long disability in children. Infants exposed to I/R brain injury develop long-term cognitive and behavioral deficits, placing a large burden on parents and society. Therapeutic strategies are currently not available for infants with I/R brain damage, except for hypothermia, which can only be used in full term infants with hypoxic-ischemic encephalopathy (HIE). Moreover, hypothermia is only partially protective...
January 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28763889/-study-of-neuron-protective-effect-and-mechanism-of-neuregulin1%C3%AE-against-cerebral-ischemia-reperfusion-induced-injury-in-rats
#17
Y Q Ji, R Zhang, L Teng, H Y Li, Y L Guo
Objective: Thecurrent study is to explore the neuron-protective mechanism of neuregulin1β (NRG1β) in a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R) through inhibiting the c-Jun phosphorylation. Methods: After 24 h of MCAO/R (referring to Longa's method), neurobehavioral function was measured by modified neurological severity score (mNSS) test; the cerebral infarction volume was detected by triphenyltetrazolium chloride (TTC) staining; the blood brain barrier (BBB) permeability was measured by Evans Blue (EB); the neuron morphology of brain tissue was observed by Nissl stain; the ultra-structures of the neurons were observed by transmission electron microscopy (TEM); the apoptotic neurons were counted by in situ cell death detection kit colocalized with NeuN; the expressions of phospho-c-Jun was determined by immunofluorescent labeling and Western blot analysis...
July 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28760594/s-oxiracetam-protect-against-ischemic-stroke-via-alleviating-blood-brain-barrier-dysfunction-in-rats
#18
Liangliang Huang, Erxin Shang, Wenxiang Fan, Xiang Li, Binbin Li, Shucheng He, Yuxin Fu, Yizhi Zhang, Yunman Li, Weirong Fang
The blood brain barrier (BBB) maintains the basic stability of the brain tissue under physiological conditions, while destroys and exaggerates brain edema and inflammatory response after ischemic stroke. In this study, we researched S-oxiracetam (S-ORC), a nootropic drug, alleviates BBB dysfunction and protects against ischemic stroke in rats. Middle cerebral artery occlusion(MCAO)/reperfusion in rats is applied to mimic ischemic stroke. One hour after reperfusion, rats are administered intravenously with different dose (0...
July 29, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28738537/phosphodiesterase-inhibitor-ameliorates-neuronal-injury-in-spinal-cord-ischemia-reperfusion-injured-rat-model
#19
Xiao-Gang Chen, Fu Hua, Shou-Guo Wang, Yong-Yi Xu, Hai-Tao Yue
This study investigated the mechanisms responsible for the neuroprotective effect of sildenafil citrate (SFC) on ischemia-reperfusion spinal cord (SC) injuries. Balloon occlusion of the thoracic aorta was used to induce SC ischemia. The animals (n=30) were separated into three groups: sham, SC injury with saline, and SC injury with 5mg/kg i.p. SFC treatment (SFC). The Basso, Beattie, and Bresnahan (BBB) score was determined to assess neurological function at different time intervals after reperfusion. After 48h, histopathology of the SC was assessed by triphenyltetrazolium chloride (TTC) and Nissl staining...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28736035/propane-2-sulfonic-acid-octadec-9-enyl-amide-a-novel-ppar%C3%AE-%C3%AE-dual-agonist-protects-against-ischemia-induced-brain-damage-in-mice-by-inhibiting-inflammatory-responses
#20
Ying Li, Lanxi Xu, Kaiyue Zeng, Zhentian Xu, Daqin Suo, Lu Peng, Tong Ren, Zhiheng Sun, Wushuang Yang, Xin Jin, Lichao Yang
Propane-2-sulfonic acid octadec-9-enyl-amide (N15), an analogue of oleoylethanolamide (OEA), is a novel PPARα/γ dual agonist. Our previous studies verified the positive effects of OEA on the acute and delayed stages of cerebral ischemia. However, it is not clear whether N15 is effective against ischemic cerebral injury. In the present study, male Kunming mice were subjected to middle cerebral artery occlusion (MCAO). To evaluate its preventive effects, N15 (50, 100 or 200mg/kg, ip) was administered for 3days before ischemia...
July 21, 2017: Brain, Behavior, and Immunity
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