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https://www.readbyqxmd.com/read/29747437/effects-of-protocatechuic-acid-pca-on-global-cerebral-ischemia-induced-hippocampal-neuronal-death
#1
A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Sang Hwon Lee, Jeong Hyun Jeong, Kyoung-Ha Park, Hong Ki Song, Hui Chul Choi, Sang Won Suh
Global cerebral ischemia (GCI) is one of the main causes of hippocampal neuronal death. Ischemic damage can be rescued by early blood reperfusion. However, under some circumstances reperfusion itself can trigger a cell death process that is initiated by the reintroduction of blood, followed by the production of superoxide, a blood⁻brain barrier (BBB) disruption and microglial activation. Protocatechuic acid (PCA) is a major metabolite of the antioxidant polyphenols, which have been discovered in green tea...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29743683/rivaroxaban-does-not-influence-hemorrhagic-transformation-in-a-diabetes-ischemic-stroke-and-endovascular-thrombectomy-model
#2
Feng-Di Liu, Rong Zhao, Xiao-Yan Feng, Yan-Hui Shi, Yi-Lan Wu, Xiao-Lei Shen, Ge-Fei Li, Yi-Sheng Liu, Ying Zhao, Xin-Wei He, Jia-Wen Yin, Mei-Ting Zhuang, Bing-Qiao Zhao, Jian-Ren Liu
Managing endovascular thrombectomy (ET) in diabetic ischemic stroke (IS) with novel anticoagulants is challenging due to putative risk of intracerebral hemorrhage. The study evaluates increased hemorrhagic transformation (HT) risk in Rivaroxaban-treated diabetic rats post ET. Diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of 60 mg/kg streptozotocin. After 4-weeks, rats were pretreated orally with 30 mg/kg Rivaroxaban/saline; prothrombin time was monitored. IS and ET was induced after 1 h, by thread-induced transient middle cerebral artery occlusion (tMCAO) that mimicked mechanical ET for proximal MCA occlusion at 60 min...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29705606/neuroprotective-effects-of-protein-tyrosine-phosphatase-1b-inhibitor-on-cerebral-ischemia-reperfusion-in-mice
#3
Meiling Sun, Hisanao Izumi, Yasuharu Shinoda, Kohji Fukunaga
Akt (Protein kinase B, PKB), a serine/threonine kinase, plays a critical role in cell development, growth, and survival. Akt phosphorylation mediates a neuroprotective effect against ischemic injury. Recently, a protein-tyrosine phosphatase-1B (PTP1B) inhibitor (KY-226) was developed to elicit anti-diabetic and anti-obesity effects via enhancement of insulin signaling. Previously, we reported that the nonselective PTP1B inhibitor, sodium orthovanadate, rescued neurons from delayed neuronal death during brain ischemia...
April 26, 2018: Brain Research
https://www.readbyqxmd.com/read/29696468/microrna-21-confers-neuroprotection-against-cerebral-ischemia-reperfusion-injury-and-alleviates-blood-brain-barrier-disruption-in-rats-via-the-mapk-signaling-pathway
#4
Xiaofeng Yao, Yahui Wang, Dongya Zhang
The mechanism contributing to blood-brain barrier (BBB) disruption, involved in poststroke edema and hemorrhagic transformation, is important but elusive. We investigated microRNA-21 (miR-21)-mediated mechanism in the disruption of BBB following cerebral ischemia-reperfusion (I/R) injury. Rats with cerebral I/R injury were prepared after middle cerebral artery occlusion and subsequent reperfusion. The underlying regulatory mechanisms of miR-382 were investigated with treatment of miR-382 mimics, miR-382 inhibitors, or SB203580 (an inhibitor of the MAPK signaling pathway) prior to I/R modeling...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29676103/-protective-effect-and-mechanism-of-p-hydroxybenzaldehyde-on-blood-brain-barrier
#5
Yan-Ping Zhu, Xin Li, Yao Du, Lu Zhang, Li Ran, Ning-Na Zhou
The disruption of blood-brain barrier(BBB) induced by oxidative stress is an important pathological reaction which results in secondary brain injury during the cerebral ischemia-reperfusion. This study was designed to investigate the protective effect and mechanism of p-hydroxybenzaldehyde (p-HBA) from Gastrodia elata on BBB. The BBB is mainly consisted of vascular endothelial cells and astrocytes, so brain microvascular endothelial cell line (bEnd.3) and astrocytes (Ast) in mice were used in this study to establish BBB model...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29665111/inhibition-of-transient-receptor-potential-vanilloid-4-decreases-the-expressions-of-caveolin-1-and-caveolin-2-after-focal-cerebral-ischemia-and-reperfusion-in-rats
#6
Hui Xie, Wei-Cheng Lu
This study aimed to investigate the effects of transient receptor potential vanilloid 4 (TRPV4) inhibition on blood-brain barrier (BBB) integrity and the expressions of caveolae structural proteins caveolin-1 and caveolin-2 in rats with focal cerebral ischemia and reperfusion. BBB permeability was assessed by Evans blue extravasation. The mRNA and protein expressions of caveolin-1 and caveolin-2 were determined by RT-PCR, Western blot and immunohistochemistry assays. We found that BBB permeability significantly increased and reaches its peak at 72 h of reperfusion in cerebral ischemia-reperfusion rats and is able to be ameliorated by administration of HC-067047, an antagonist of TRPV4...
April 17, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29626425/salidroside-improves-brain-ischemic-injury-by-activating-pi3k-akt-pathway-and-reduces-complications-induced-by-delayed-tpa-treatment
#7
Wei Zuo, Feng Yan, Bo Zhang, Xiaomin Hu, Dan Mei
Cerebral ischemia causes blood-brain barrier (BBB) injury and thus increases the risk of complications secondary to thrombolysis, which limited its clinical application. This study aims to clarify the role and mechanism of salidroside (SALD) in alleviating brain ischemic injury and whether pretreatment of it could improve prognosis of delayed treatment of tissue plasminogen activator (t-PA). Rats were subjected to 3h of middle cerebral artery occlusion (MCAO) and were intraperitoneally administered with 10, 20 or 40mg/kg SALD before ischemia...
April 4, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29622432/sirtuin-5-as-a-novel-target-to-blunt-blood-brain-barrier-damage-induced-by-cerebral-ischemia-reperfusion-injury
#8
Candela Diaz-Cañestro, Mario Merlini, Nicole R Bonetti, Luca Liberale, Patricia Wüst, Sylvie Briand-Schumacher, Jan Klohs, Sara Costantino, Melroy Miranda, Gabriele Schoedon-Geiser, Gerd A Kullak-Ublick, Alexander Akhmedov, Francesco Paneni, Jürg H Beer, Thomas F Lüscher, Giovanni G Camici
BACKGROUND: In acute ischemic stroke (AIS) patients, impaired blood-brain barrier (BBB) integrity is associated with hemorrhagic transformation and worsened outcome. Yet, the mechanisms underlying these relationships are poorly understood and consequently therapeutic strategies are lacking. This study sought to determine whether SIRT5 contributes to BBB damage following I/R brain injury. METHODS AND RESULTS: SIRT5 knockout (SIRT5-/- ) and wild type (WT) mice underwent transient middle cerebral artery (MCA) occlusion (tMCAO) followed by 48h of reperfusion...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29595191/targeting-rns-caveolin-1-mmp-signaling-cascades-to-protect-against-cerebral-ischemia-reperfusion-injuries-potential-application-for-drug-discovery
#9
REVIEW
Han-Sen Chen, Xi Chen, Wen-Ting Li, Jian-Gang Shen
Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-reperfusion injury. RNS activate multiple signaling pathways and participate in different cellular events in cerebral ischemia-reperfusion injury. Recent studies have indicated that caveolin-1 and matrix metalloproteinase (MMP) are important signaling molecules in the pathological process of ischemic brain injury. During cerebral ischemia-reperfusion, the production of nitric oxide (NO) and peroxynitrite (ONOO- ), two representative RNS, down-regulates the expression of caveolin-1 (Cav-1) and, in turn, further activates nitric oxide synthase (NOS) to promote RNS generation...
March 29, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29576054/salvianolic-acid-a-attenuates-ischemia-reperfusion-induced-rat-brain-damage-by-protecting-the-blood-brain-barrier-through-mmp-9-inhibition-and-anti-inflammation
#10
Wen Zhang, Jun-Ke Song, Xue Zhang, Qi-Meng Zhou, Guo-Rong He, Xiao-Na Xu, Yan Rong, Wen-Xia Zhou, Guan-Hua DU
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to determine the brain protective effects of SAA against cerebral ischemia reperfusion injury in rats, and to figure out whether SAA could protect the blood brain barrier (BBB) through matrix metallopeptidase 9 (MMP-9) inhibition. A focal cerebral ischemia reperfusion model was induced by middle cerebral artery occlusion (MCAO) for 1...
March 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29569041/non-invasive-multimodality-imaging-directly-shows-trpm4-inhibition-ameliorates-stroke-reperfusion-injury
#11
Bo Chen, Gandi Ng, Yahui Gao, See Wee Low, Edwin Sandanaraj, Boominathan Ramasamy, Sakthivel Sekar, Kishore Bhakoo, Tuck Wah Soong, Bernd Nilius, Carol Tang, Edward G Robins, Julian Goggi, Ping Liao
The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study, we used multimodal imaging to assess edema formation and quantify the amount of metabolically functional brain salvaged after a rat model of stroke reperfusion. TRPM4 upregulation in endothelium emerges as early as 2 h post-stroke induction. Expression of TRPM4 channel was suppressed directly in vivo by treatment with siRNA; scrambled siRNA was used as a control...
March 22, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29527151/protective-effects-of-l-902-688-a-prostanoid-ep4-receptor-agonist-against-acute-blood-brain-barrier-damage-in-experimental-ischemic-stroke
#12
Kelly M DeMars, Austin O McCrea, David M Siwarski, Brian D Sanz, Changjun Yang, Eduardo Candelario-Jalil
Ischemic stroke occurs when a clot forms in the brain vasculature that starves downstream tissue of oxygen and nutrients resulting in cell death. The tissue immediately downstream of the blockage, the core, dies within minutes, but the surrounding tissue, the penumbra is potentially salvageable. Prostaglandin E2 binds to four different G-protein coupled membrane receptors EP1-EP4 mediating different and sometimes opposing responses. Pharmacological activation of the EP4 receptor has already been established as neuroprotective in stroke, but the mechanism(s) of protection are not well-characterized...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29524637/autophagy-and-mmp-2-9-mediated-reduction-and-redistribution-of-zo-1-contribute-to-hyperglycemia-increased-blood-brain-barrier-permeability-during-early-reperfusion-in-stroke
#13
Shuai Zhang, Qier An, Tianfu Wang, Shuping Gao, Guangqian Zhou
Post-stroke hyperglycemia during early reperfusion increases blood-brain barrier (BBB) permeability and subsequently aggravates brain injury and clinical prognosis. The decreased level of tight junction proteins (TJPs) has been reported but the underlying mechanism remains largely elusive. Herein we designed to investigate the detailed molecular events in brain microvascular endothelial cells (BMECs) ex and in vivo. After oxygen-glucose deprivation (OGD) for 90 min and reperfusion with 8 or 16 mM glucose for 30 min, glucose at 16 mM caused significant decrease in the TJP expression and particularly ZO-1 redistribution from membrane to cytoplasm of BMECs...
May 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29499167/salubrinal-and-robenacoxib-treatment-after-global-cerebral-ischemia-exploring-the-interactions-between-er-stress-and-inflammation
#14
Berta Anuncibay-Soto, Diego Pérez-Rodriguez, María Santos-Galdiano, Enrique Font-Belmonte, Irene F Ugidos, Paloma Gonzalez-Rodriguez, Marta Regueiro-Purriños, Arsenio Fernández-López
BACKGROUND: Blood reperfusion of the ischemic tissue after stroke promotes increases in the inflammatory response as well as accumulation of unfolded/misfolded proteins in the cell, leading to endoplasmic reticulum (ER) stress. Both Inflammation and ER stress are critical processes in the delayed death of the cells damaged after ischemia. The aim of this study is to check the putative synergic neuroprotective effect by combining anti-inflammatory and anti-ER stress agents after ischemia...
May 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29484769/early-blood-brain-barrier-disruption-after-mechanical-thrombectomy-in-acute-ischemic-stroke
#15
Zhong-Song Shi, Gary R Duckwiler, Reza Jahan, Satoshi Tateshima, Viktor Szeder, Jeffrey L Saver, Doojin Kim, Latisha K Sharma, Paul M Vespa, Noriko Salamon, J Pablo Villablanca, Fernando Viñuela, Lei Feng, Yince Loh, David S Liebeskind
BACKGROUND AND PURPOSE: The impact of blood-brain barrier (BBB) disruption can be detected by intraparenchymal hyperdense lesion on the computed tomography (CT) scan after endovascular stroke therapy. The purpose of this study was to determine whether early BBB disruption predicts intracranial hemorrhage and poor outcome in patients with acute ischemic stroke treated with mechanical thrombectomy. METHODS: We analyzed patients with anterior circulation stroke treated with mechanical thrombectomy and identified BBB disruption on the noncontrast CT images immediately after endovascular treatment...
May 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29467855/clinical-characteristics-and-value-in-early-reperfusion-therapy-for-new-onset-right-bundle-branch-block-in-patients-with-acute-myocardial-infarction
#16
Jingchao Li, Xiaodong Li, Shujuan Dong, Yapan Yang, Yingjie Chu
The value of the right bundle branch block (RBBB) in the treatment of acute myocardial infarction remains unclear. Studies on the RBBB may significantly influence the treatment of acute myocardial infarction. A total of 845 patients with acute myocardial infarction who underwent primary coronary angiography at Henan Provincial People's Hospital were analyzed. Higher peak enzyme levels, a higher ratio of Killip ≥II and closer proximal occlusion of infarct-related artery (IRA) were observed in patients with RBBB compared with those without...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29425910/neuroprotective-effects-of-tongxinluo-on-focal-cerebral-ischemia-and-reperfusion-injury-in-rats-associated-with-the-activation-of-the-mek1-2-erk1-2-p90rsk-signaling-pathway
#17
Zhonghai Yu, Min Cai, Xianting Li, Jingsi Zhang, Ting Wu, Feng Yang, Wen Zhu, Yijin Xiang, Wen Zhang, Jun Xiang, Dingfang Cai
Ischemic stroke brings a huge family and social burden. Although the reperfusion of ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia-reperfusion (I/R) injury further results in brain damage and even lead to death. Recent studies demonstrated that Tongxinluo (TXL) helps to protect the brain against focal cerebral I/R injury in rats by reducing neuronal apoptosis, and the MEK1/2/ERK1/2/90 ribosomal S6 kinase (p90RSK) pathway may be involved in this protective effect. Therefore, our present research was designed to identify the potential mechanisms involved...
April 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29421566/protecting-neurons-from-cerebral-ischemia-reperfusion-injury-via-nanoparticle-mediated-delivery-of-an-sirna-to-inhibit-microglial-neurotoxicity
#18
Ye Wang, Shi-Yong Li, Song Shen, Jun Wang
Complement component C3 (C3) plays a central role in microglial neurotoxicity following cerebral ischemia/reperfusion (I/R) injury. In this study, we focused on the role of nanoparticles loaded with C3 siRNA (NPsiC3 ) in inhibiting microglial neurotoxicity after brain (I/R) injury. NPsiC3 inhibited the hypoxia/re-oxygenation-induced increase in C3 expression in microglia in vitro. Importantly, treatment with NPsiC3 decreased C3b deposition on neurons and reduced microglia-mediated neuronal damage under hypoxia/re-oxygen conditions...
April 2018: Biomaterials
https://www.readbyqxmd.com/read/29408288/neuroprotective-nature-of-adipokine-resistin-in-the-early-stages-of-focal-cerebral-ischemia-in-a-stroke-mouse-model
#19
Sedigheh Behrouzifar, Abedin Vakili, Ahmad Reza Bandegi, Parviz Kokhaei
New evidence suggests that resistin may have a therapeutic potential effect in management of neurodegenerative disease; but its role in the pathophysiology of stroke-induced injuries is not understood. However, further investigations are required to elucidate the effect of resistin and explore its possible molecular mechanisms on the ischemic reperfusion injury. Transient focal cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO) in mice. Animal treated with resistin at doses of 25, 50, 100, 200, and 400 ng/mouse, on the MCAO commencement...
March 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29401609/microrna-149-5p-regulates-blood-brain-barrier-permeability-after-transient-middle-cerebral-artery-occlusion-in-rats-by-targeting-s1pr2-of-pericytes
#20
Yan Wan, Hui-Juan Jin, Yi-Yi Zhu, Zhi Fang, Ling Mao, Quanwei He, Yuan-Peng Xia, Man Li, Yanan Li, Xiaoqian Chen, Bo Hu
Blood-brain barrier (BBB) disruption caused by reperfusion injury after ischemic stroke is an intractable event conducive to further injury. Brain pericytes play a vital role in maintaining BBB integrity by interacting with other components of the BBB. In this study, we found that sphingosine-1-phosphate receptor (S1PR)2 expressed in pericytes was significantly up-regulated after ischemia in vivo and in vitro. By using a S1PR2 antagonist (JTE-013), we showed that S1PR2 plays a critical role in the induction of BBB permeability of transient middle cerebral artery occlusion (tMCAO) rats and the in vitro BBB model...
January 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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