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EDITORIAL
Vlasios Sotirchos, Constantinos T Sofocleous
No abstract text is available yet for this article.
June 1, 2023: Cardiovascular and Interventional Radiology
#22
JOURNAL ARTICLE
Ken Zhao, Joseph P Erinjeri, Vlasios S Sotirchos, Erica S Alexander, Amgad M Moussa, Brett Marinelli, Etay Ziv, Constantinos T Sofocleous, Ghassan K Abou-Alfa, William R Jarnagin, Anita Karimi, Hooman Yarmohammadi
PURPOSE: Transarterial radioembolization (TARE) is a liver-directed treatment for unresectable intrahepatic cholangiocarcinoma (ICC). The aim of this study is to evaluate factors affecting outcomes of TARE in heavily pretreated ICC patients. METHODS: We evaluated pretreated ICC patients who received TARE from January 2013 to December 2021. Prior treatments included systemic therapy, hepatic resection, and liver-directed therapies, including hepatic arterial infusion chemotherapy, external beam radiation, transarterial embolization, and thermal ablation...
May 5, 2023: Abdominal Radiology
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REVIEW
Yuliya Kitsel, Timothy Cooke, Vlasios Sotirchos, Constantinos T Sofocleous
Molecular cancer biomarkers help personalize treatment, predict oncologic outcomes, and identify patients who can benefit from specific targeted therapies. Colorectal cancer (CRC) is the third-most common cancer, with the liver being the most frequent visceral metastatic site. KRAS, NRAS, BRAF V600E Mutations, DNA Mismatch Repair Deficiency/Microsatellite Instability Status, HER2 Amplification, and NTRK Fusions are NCCN approved and actionable molecular biomarkers for colorectal cancer. Additional biomarkers are also described and can be helpful in different image-guided hepatic directed therapies specifically for CRLM...
March 9, 2023: Cancers
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JOURNAL ARTICLE
John J Chen, Eoin P Flanagan, Sean J Pittock, Nicole Caroline Stern, Nanthaya Tisavipat, M Tariq Bhatti, Kevin D Chodnicki, Deena A Tajfirouz, Sepideh Jamali, Amy Kunchok, Eric R Eggenberger, Marie A Di Nome, Elias S Sotirchos, Eleni S Vasileiou, Amanda D Henderson, Anthony C Arnold, Laura Bonelli, Heather E Moss, Sylvia Elizabeth Villarreal Navarro, Tanyatuth Padungkiatsagul, Hadas Stiebel-Kalish, Itay Lotan, Adi Wilf-Yarkoni, Helen Danesh-Meyer, Stefan Ivanov, Saif Huda, Mirasol Forcadela, David Hodge, Pascale Poullin, Julie Rode, Caroline Papeix, Samir Saheb, Marine Boudot de la Motte, Catherine Vignal, Yael Hacohen, Julie Pique, Elisabeth Maillart, Romain Deschamps, Bertrand Audoin, Romain Marignier
PURPOSE: To evaluate the effectiveness of plasma exchange (PLEX) for optic neuritis (ON). METHODS: We conducted an international multicenter retrospective study evaluating the outcomes of ON following PLEX. Outcomes were compared to raw data from the Optic Neuritis Treatment Trial (ONTT) using a matched subset. RESULTS: A total of 395 ON attack treated with PLEX from 317 patients were evaluated. The median age was 37 years (range 9 to 75) and 71% were female...
February 21, 2023: American Journal of Ophthalmology
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JOURNAL ARTICLE
Mahdi Zirakchian Zadeh, Randy Yeh, Henry S Kunin, Assen S Kirov, Elena N Petre, Mithat Gönen, Mikhail Silk, Francois H Cornelis, Kevin C Soares, Etay Ziv, Stephen B Solomon, Vlasios S Sotirchos, Constantinos T Sofocleous
BACKGROUND: Real-time split-dose PET can identify the targeted colorectal liver metastasis (CLM) and eliminate the need for repeated contrast administration before and during thermal ablation (TA). This study aimed to assess the added value of pre-ablation real-time split-dose PET when combined with non-contract CT in the detection of CLM for ablation and the evaluation of the ablation zone and margins. METHODS: A total of 190 CLMs/125 participants from two IRB-approved prospective clinical trials using PET/CT-guided TA were analyzed...
December 19, 2022: Cancers
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JOURNAL ARTICLE
Grigorios Kalaitzidis, Nicole Pellegrini, Natalia Nagy, Eleni Vasileiou, Henrik Ehrhardt, Abbey Reppen, Olwen C Murphy, Hussein Moussa, Angeliki Filippatou, Jeffrey Lambe, Anna DuVal, Nicholas Fioravante, Ohemaa Kwakyi, James Nguyen, Simidele Davis, Morgan Douglas, Alexandra Ramirez, Katie Ecoff, Alyssandra Valenzuela, Maria Reyes-Mantilla, Chen Hu, Kathryn C Fitzgerald, Elias S Sotirchos, Shiv Saidha, Peter A Calabresi
PURPOSE: To quantify the associations of myopia with longitudinal changes in retinal layer thicknesses in people with multiple sclerosis (PwMS) and healthy controls (HC). METHODS: A cohort of PwMS and HC with recorded refractive error (RE) prospectively scanned on Cirrus HD-OCT at the Johns Hopkins MS Center was assessed for inclusion. Exclusion criteria included OCT follow-up < 6 months, ocular comorbidities, incidental OCT pathologies, and inadequate scan quality...
November 28, 2022: Current Eye Research
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JOURNAL ARTICLE
Dohyup Kim, Emily E Witt, Simone Schubert, Elias Sotirchos, Pavan Bhargava, Ellen M Mowry, Karen Sachs, Biter Bilen, Lawrence Steinman, Avni Awani, Zihuai He, Peter A Calabresi, Keith Van Haren
Vitamin D is a steroid hormone that has been widely studied as a potential therapy for multiple sclerosis and other inflammatory disorders. Pre-clinical studies have implicated vitamin D in the transcription of thousands of genes, but its influence may vary by cell type. A handful of clinical studies have failed to identify an in vivo gene expression signature when using bulk analysis of all peripheral immune cells. We hypothesized that vitamin D's gene signature would vary by immune cell type, requiring the analysis of distinct cell types...
November 9, 2022: Nutrients
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JOURNAL ARTICLE
Elias S Sotirchos, Kathryn C Fitzgerald, Carol M Singh, Matthew D Smith, Maria Reyes-Mantilla, Carrie M Hersh, Megan H Hyland, Ryan Canissario, Sarah B Simmons, Georgina Arrambide, Xavier Montalban, Manuel Comabella, Robert T Naismith, Min Qiao, Lauren B Krupp, Jacqueline A Nicholas, Katja Akgün, Tjalf Ziemssen, Richard Rudick, Elizabeth Fisher, Robert A Bermel, Ellen M Mowry, Peter A Calabresi
OBJECTIVE: Evaluation of serum neurofilament light chain (sNfL), measured using high-throughput assays on widely accessible platforms in large, real-world MS populations, is a critical step for sNfL to be utilized in clinical practice. METHODS: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is a network of healthcare institutions in the United States and Europe collecting standardized clinical/imaging data and biospecimens during routine clinic visits...
November 25, 2022: Annals of Clinical and Translational Neurology
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JOURNAL ARTICLE
Eleni S Vasileiou, Chen Hu, Charles N Bernstein, Fred Lublin, Jerry S Wolinsky, Gary R Cutter, Elias S Sotirchos, Kaarina Kowalec, Amber Salter, Shiv Saidha, Ellen M Mowry, Peter A Calabresi, Ruth Ann Marrie, Kathryn C Fitzgerald
BACKGROUND AND OBJECTIVES: Observational studies suggest low levels of 25-hydroxyvitamin D (25[OH]D) may be associated with increased disease activity in people with multiple sclerosis (PwMS). Large-scale genome-wide association studies (GWAS) suggest 25(OH)D levels are partly genetically determined. The resultant polygenic scores (PGSs) could serve as a proxy for 25(OH)D levels, minimizing potential confounding and reverse causation in analyses with outcomes. Herein, we assess the association of genetically determined 25(OH)D and disease outcomes in MS...
January 2023: Neurology® Neuroimmunology & Neuroinflammation
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JOURNAL ARTICLE
Dimitrios C Ladakis, Jennifer Gould, Jenny M Khazen, Julia M Lefelar, Scott Tarpey, Charles J Bies, Rebecca Salky, Kathryn C Fitzgerald, Pavan Bhargava, Bardia Nourbakhsh, Elias S Sotirchos
BACKGROUND: Unlike multiple sclerosis and neuromyelitis optica, the burden of fatigue in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unclear. OBJECTIVE: To compare fatigue levels between people with MOGAD and household controls (HC) and explore factors associated with fatigue severity. METHODS: In a cross-sectional survey, data were collected from people with MOGAD and HC by utilizing an online questionnaire...
2022: Multiple Sclerosis Journal—Experimental, Translational and Clinical
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JOURNAL ARTICLE
Vivek A Pisharody, Hooman Yarmohammadi, Etay Ziv, Vlasios S Sotirchos, Erica Alexander, Constantino Sofocleous, Joseph P Erinjeri
Reducing patient wait times is a key operational goal and impacts patient outcomes. The purpose of this study is to explore the effects of different radiology scheduling strategies on exam wait times before and after holiday periods at an outpatient imaging facility using computer simulation. An idealized Monte Carlo simulation of exam scheduling at an outpatient imaging facility was developed based on the actual distribution of scheduled exams at outpatient radiology sites at a tertiary care medical center...
November 7, 2022: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
#32
JOURNAL ARTICLE
John J Chen, Eoin P Flanagan, M Tariq Bhatti, Nanthaya Tisavipat, Sepideh Jamali, Amy Kunchok, Eric R Eggenberger, Marie Di Nome, Elias S Sotirchos, Eleni S Vasileiou, Amanda D Henderson, Anthony C Arnold, Laura Bonelli, Nicolas Seleme, Alvaro J Mejia-Vergara, Heather E Moss, Tanyatuth Padungkiatsagul, Hadas Stiebel-Kalish, Itay Lotan, Adi Wilf-Yarkoni, Mark A Hellmann, Amrita Vuppala, David Hodge, Sean J Pittock
BACKGROUND: The goal of this study was to examine the temporal relationship of eye pain to visual loss and investigate whether timing of steroid treatment affects the rate and extent of visual recovery in optic neuritis (ON) from MOG-IgG associated disease (MOGAD) in a large cohort of MOGAD patients with ON. METHODS: This is a multicenter, retrospective cohort study of consecutive MOGAD patients with ON attacks seen from 2017 to 2021 fulfilling the following criteria: (1) clinical history of ON; (2) MOG-IgG seropositivity...
October 10, 2022: Multiple Sclerosis and related Disorders
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JOURNAL ARTICLE
Paula Barreras, Eleni S Vasileiou, Angeliki G Filippatou, Kathryn C Fitzgerald, Michael Levy, Carlos A Pardo, Scott D Newsome, Ellen M Mowry, Peter A Calabresi, Elias S Sotirchos
BACKGROUND AND OBJECTIVES: Rituximab is used widely for relapse prevention in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease (MOGAD); however, data regarding the effectiveness and safety of long-term rituximab use in these conditions are limited. In this study, we sought to evaluate long-term clinical outcomes in patients with aquaporin-4 IgG-seropositive (AQP4-IgG+) NMOSD and MOGAD treated with rituximab. METHODS: We performed a retrospective chart review of patients with AQP4-IgG+ NMOSD or MOGAD followed at the Johns Hopkins Neuromyelitis Optica Clinic and included patients who had received at least 1 dose of rituximab...
November 29, 2022: Neurology
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JOURNAL ARTICLE
Olwen C Murphy, Elias S Sotirchos, Grigorios Kalaitzidis, Elena Vasileiou, Henrik Ehrhardt, Jeffrey Lambe, Ohemaa Kwakyi, James Nguyen, Alexandra Zambriczki Lee, Julia Button, Blake E Dewey, Scott D Newsome, Ellen M Mowry, Kathryn C Fitzgerald, Jerry L Prince, Peter A Calabresi, Shiv Saidha
OBJECTIVE: To explore longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis (AON) in people with multiple sclerosis (PwMS), to investigate the process of trans-synaptic degeneration, and determine its clinical relevance. METHODS: PwMS were recruited within 40 days of AON onset (n = 49), and underwent baseline retinal optical coherence tomography and brain magnetic resonance imaging followed by longitudinal tracking for up to 5 years...
January 2023: Annals of Neurology
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JOURNAL ARTICLE
Jennifer A Schroeder, Quy Cao, Vlasios S Sotirchos, Jennifer A Gillman, Thomas Anderson, Stamatoula Pilati, Jacob G Dubroff, Michael Farwell, Andrew Kozlov, Katrina Korhonen, Daniel A Pryma, Austin R Pantel
This study seeks to understand the value of ventilation imaging in pregnant patients imaged for suspected pulmonary embolism (PE). Ventilation-perfusion (VQ) scans in this high-risk population were compared to ventilation-only scans. We hypothesize that in this relatively healthy population, the exclusion of ventilation scans will not impact the rate of scans interpreted as positive. This retrospective blinded comparative reader study on collated VQ scans performed on pregnant patients in the course of routine clinical care in a > 5 year period (03/2012 to 07/2017)...
September 30, 2022: Medicine (Baltimore)
#36
JOURNAL ARTICLE
Grigorios Kalaitzidis, Angeliki Filippatou, Nicholas Fioravante, Alissa Rothman, Elias S Sotirchos, Eleni Vasileiou, Henrik Ehrhardt, Agustina Quiroga, Nicole Pellegrini, Olwen C Murphy, Hussein Moussa, Dimitrios C Ladakis, Jeffrey Lambe, Kathryn C Fitzgerald, Lilja Solnes, Arun Venkatesan, Peter A Calabresi, Shiv Saidha, John C Probasco
BACKGROUND: Anti-NMDA receptor (NMDAR) encephalitis patients have been reported to exhibit visual dysfunction without retinal thinning. The objective of our study was to examine the involvement of the visual pathway structure and function in anti-NMDAR encephalitis by assessing postrecovery visual function and retinal structure, and acute-phase occipital cortex function. METHODS: In this cross-sectional study, patients diagnosed with anti-NMDAR encephalitis per consensus criteria underwent postrecovery visual acuity (VA) testing and optical coherence tomography (OCT) with automated retinal layer segmentation...
August 24, 2022: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#37
JOURNAL ARTICLE
Lynn Daboul, Carly M O'Donnell, Quy Cao, Moein Amin, Paulo Rodrigues, John Derbyshire, Christina Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter Calabresi, Bruce A C Cree, Leorah Freeman, Roland G Henry, Erin E Longbrake, Kunio Nakamura, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D Samudralwar, Suradech Suthiphosuwan, Matthew K Schindler, Elias S Sotirchos, Nancy L Sicotte, Andrew J Solomon, Russell T Shinohara, Daniel S Reich, Daniel Ontaneda, Pascal Sati
Background: The central vein sign (CVS) is a proposed MRI biomarker of multiple sclerosis (MS). The impact of gadolinium-based contrast agent (GBCA) administration on CVS evaluation remains poorly investigated. Objective: To assess the effect of GBCA use on CVS detection and on the diagnostic performance of the CVS for MS, using a 3-T FLAIR* sequence. Methods: This study was a secondary analysis of data from the prospective multicenter Central Vein Sign in MS (CAVS-MS) Pilot study, which recruited adults with suspected MS from April 2018 to February 2020...
August 17, 2022: AJR. American Journal of Roentgenology
#38
JOURNAL ARTICLE
Nikiforos Vasiniotis Kamarinos, Mithat Gonen, Vlasios Sotirchos, Elena Kaye, Elena N Petre, Stephen B Solomon, Joseph P Erinjeri, Etay Ziv, Assen Kirov, Constantinos T Sofocleous
OBJECTIVE: To determine the feasibility and prognostic value of 3D measuring of the ablation margins using a dedicated image registration software. METHODS: This retrospective study included 104 colorectal liver metastases in 68 consecutive patients that underwent microwave ablation between 08/2012 and 08/2019. The minimal ablation margin (MM) was measured in 2D using anatomic landmarks on contrast enhanced CT(CECT) 4-8 weeks post-ablation, and in 3D using an image registration software and immediate post-ablation CECT...
2022: International Journal of Hyperthermia
#39
JOURNAL ARTICLE
Dimitrios C Ladakis, Pamela J Yao, Michael Vreones, Joseph Blommer, Grigorios Kalaitzidis, Elias S Sotirchos, Kathryn C Fitzgerald, Shiv Saidha, Peter A Calabresi, Dimitrios Kapogiannis, Pavan Bhargava
BACKGROUND: Mitochondrial dysfunction plays an important role in multiple sclerosis (MS) disease progression. Plasma extracellular vesicles are a potential source of novel biomarkers in MS, and some of these are derived from mitochondria and contain functional mitochondrial components. OBJECTIVE: To evaluate the relationship between levels of mitochondrial complex IV and V activity in neuronally enriched extracellular vesicles (NEVs) and brain and retinal atrophy as assessed using serial magnetic resonance imaging (MRI) and optical coherence tomography (OCT)...
July 5, 2022: Multiple Sclerosis: Clinical and Laboratory Research
#40
JOURNAL ARTICLE
Kathryn C Fitzgerald, Elias S Sotirchos, Matthew D Smith, Hannah-Noelle Lord, Anna DuVal, Ellen M Mowry, Peter A Calabresi
OBJECTIVE: To assess the effects of demographics, lifestyle factors, and comorbidities on serum neurofilament light chain (sNfL) levels in people without neurologic disease and establish demographic-specific reference ranges of sNfL. METHODS: The National Health and Nutrition Examination Survey (NHANES) is a representative sample of the US population in which detailed information on demographic, lifestyle, routine laboratory tests, and overall health status are systematically collected...
October 2022: Annals of Neurology
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