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https://www.readbyqxmd.com/read/29125422/characteristics-of-morphologic-macular-abnormalities-in-neuroimmunology-practice
#1
Omar Al-Louzi, Elias S Sotirchos, Angela Vidal-Jordana, Shin C Beh, Julia Button, Howard S Ying, Laura J Balcer, Elliot M Frohman, Shiv Saidha, Peter A Calabresi, Scott D Newsome
BACKGROUND: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. OBJECTIVE: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. METHODS: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28652923/jc-virus-granule-cell-neuronopathy-onset-two-months-after-chemotherapy-for-low-grade-lymphoma
#2
Kathryn B Holroyd, Elias S Sotirchos, Scott R DeBoer, Kelly A Mills, Scott D Newsome
BACKGROUND: Granule cell neuronopathy (GCN) is a rare disease caused by the JC virus, leading to degeneration of cerebellar granule cell neurons. Primarily described in patients with AIDS, it has also been diagnosed in patients with lymphoproliferative diseases and after long-term treatment with immune-suppressing medications such as natalizumab. CASE PRESENTATION: A 69 year old woman presented with progressive ataxia which began 2 months after initiation of treatment for follicular low-grade B cell lymphoma with rituximab/bendamustine, and progressed for 2 years prior to admission...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28179329/de-novo-renal-cell-carcinoma-of-native-kidneys-in-renal-transplant-recipients-a-single-center-experience
#3
Demetrios Moris, Kiriaki Kakavia, Chrysoula Argyrou, Nikolaos Garmpis, John Bokos, Spyridon Vernadakis, Konstantinos Diles, Georgios Sotirchos, John Boletis, Georgios Zavos
BACKGROUND: The risk of renal cell carcinoma (RCC) development in renal transplant recipients is 15-100 times higher than in the general population. The majority of RCCs found in renal transplant recipients develop in the recipient's native kidneys, only 9% of tumors develop in the allograft itself. The mechanisms of development of RCC in native kidneys and renal allografts are not completely understood. We present our experience in renal transplant recipients with RCC of native kidneys providing valuable and clinically applicable treatment and follow-up data...
February 2017: Anticancer Research
https://www.readbyqxmd.com/read/27938318/incisional-infections-after-renal-transplant-outcome-data-from-238-consecutive-recipients
#4
Demetrios Moris, Spyridon Davakis, Kiriaki Kakavia, John Bokos, Spyridon Vernadakis, Konstantinos Diles, Georgios Sotirchos, Alexandros Barlas, Mina Psychogiou, Georgios Zavos
OBJECTIVES: Surgical incision infections, along with urinary tract infections, are among the most common infective complications after kidney transplant. The aim of this retrospective study is to evaluate the incidence and predisposing factors of surgical incision infection development in renal transplant recipients. MATERIALS AND METHODS: Between 1 January 2012 and 31 December 2015, there were 238 consecutive kidney transplant procedures performed in our unit. Of these, 146 patients received deceased donor kidney allografts and 92 had transplants from living related donors...
August 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27672169/safety-and-immunologic-effects-of-high-vs-low-dose-cholecalciferol-in-multiple-sclerosis
#5
Daniel Kantor, Elias S Sotirchos, Peter A Calabresi
No abstract text is available yet for this article.
September 27, 2016: Neurology
https://www.readbyqxmd.com/read/27468837/erratum-to-pharmacokinetics-safety-and-efficacy-of-chemoembolization-with-doxorubicin-loaded-tightly-calibrated-small-microspheres-in-patients-with-hepatocellular-carcinoma
#6
Katerina Malagari, Theodoros Kiakidis, Maria Pomoni, Hippokratis Moschouris, Emmanouil Emmanouil, Themis Spiridopoulos, Vlasios Sotirchos, Savvas Tandeles, Dimitrios Koundouras, Alexios Kelekis, Dimitrios Filippiadis, Angelos Charokopakis, Evanthia Bouma, Achilles Chatziioannou, Spyridon Dourakis, John Koskinas, Theodoros Karampelas, Konstantinos Tamvakopoulos, Nikolaos Kelekis, Dimitrios Kelekis
No abstract text is available yet for this article.
July 28, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27462040/safety-and-immunologic-effects-of-high-vs-low-dose-cholecalciferol-in-multiple-sclerosis
#7
Daniel Golan, Ariel Miller, Elias S Sotirchos, Pavan Bhargava, Peter A Calabresi
No abstract text is available yet for this article.
July 26, 2016: Neurology
https://www.readbyqxmd.com/read/27462039/safety-and-immunologic-effects-of-high-vs-low-dose-cholecalciferol-in-multiple-sclerosis
#8
Jagannadha Avasarala, Elias S Sotirchos, Pavan Bhargava, Peter A Calabresi
No abstract text is available yet for this article.
July 26, 2016: Neurology
https://www.readbyqxmd.com/read/27393274/pharmacokinetics-safety-and-efficacy-of-chemoembolization-with-doxorubicin-loaded-tightly-calibrated-small-microspheres-in-patients-with-hepatocellular-carcinoma
#9
Katerina Malagari, Theodoros Kiakidis, Maria Pomoni, Hippokratis Moschouris, Emmanouil Emmanouil, Themis Spiridopoulos, Vlasios Sotirchos, Savvas Tandeles, Dimitrios Koundouras, Alexios Kelekis, Dimitrios Filippiadis, Angelos Charokopakis, Evanthia Bouma, Achilles Chatziioannou, Spyridon Dourakis, John Koskinas, Theodoros Karampelas, Konstantinos Tamvakopoulos, Nikolaos Kelekis, Dimitrios Kelekis
PURPOSE: This study examines safety, efficacy, and pharmacokinetics of chemoembolization with loadable microspheres ≤100 μm for hepatocellular carcinoma. MATERIALS AND METHODS: A pilot safety study was performed in 19 patients with size and dose escalation and then 52 patients were enrolled prospectively and randomly assigned to chemoembolization with TANDEM™ loaded with 150 or 100 mg of doxorubicin. RESULTS: The mean diameter of the tumors was 7...
October 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27384594/surrogate-imaging-biomarkers-of-response-of-colorectal-liver-metastases-after-salvage-radioembolization-using-90y-loaded-resin-microspheres
#10
Waleed Shady, Vlasios S Sotirchos, Richard K Do, Neeta Pandit-Taskar, Jorge A Carrasquillo, Mithat Gonen, Constantinos T Sofocleous
OBJECTIVE: The purpose of the present study is to evaluate Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, tumor attenuation criteria, Choi criteria, and European Organization for Research and Treatment of Cancer (EORTC) PET criteria as measures of response and subsequent predictors of liver progression-free survival (PFS) after radioembolization (RE) of colorectal liver metastases (CLM). The study also assesses interobserver variability for measuring tumor attenuation using a single 2D ROI on a simple PACS workstation...
September 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27228089/intestinal-perforation-in-renal-transplant-recipients-a-single-center-experience-of-2123-recipients
#11
Kyriaki Kakavia, Demetrios Moris, Elli Karatza, John Bokos, Spiridon Vernadakis, Alexandros Barlas, Georgios Sotirchos, Konstantinos Diles, Spyridon Drakopoulos, Georgios Zavos
OBJECTIVES: Intestinal perforation remains a clinical challenge and potentially lethal complication in renal transplant recipients. Immunosuppression not only places the patient at risk for intestinal perforation but also masks classic clinical symptoms and signs of acute abdominal pain, leading to delayed diagnosis and proper treatment. The aim of our study is to present the experience of our center on the treatment of intestinal perforation in renal transplant recipients. MATERIALS AND METHODS: This study reported 11 patients (0...
October 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27010254/colorectal-cancer-liver-metastases-biopsy-of-the-ablation-zone-and-margins-can-be-used-to-predict-oncologic-outcome
#12
Vlasios S Sotirchos, Lydia M Petrovic, Mithat Gönen, David S Klimstra, Richard K G Do, Elena N Petre, Alessandra R Garcia, Afsar Barlas, Joseph P Erinjeri, Karen T Brown, Anne M Covey, William Alago, Lynn A Brody, Ronald P DeMatteo, Nancy E Kemeny, Stephen B Solomon, Katia O Manova-Todorova, Constantinos T Sofocleous
Purpose To establish the prognostic value of biopsy of the central and marginal ablation zones for time to local tumor progression (LTP) after radiofrequency (RF) ablation of colorectal cancer liver metastasis (CLM). Materials and Methods A total of 47 patients with 67 CLMs were enrolled in this prospective institutional review board-approved and HIPAA-compliant study between November 2009 and August 2012. Mean tumor size was 2.1 cm (range, 0.6-4.3 cm). Biopsy of the center and margin of the ablation zone was performed immediately after RF ablation (mean number of biopsy samples per ablation zone, 1...
September 2016: Radiology
https://www.readbyqxmd.com/read/26912433/18f-fdg-pet-ct-is-an-immediate-imaging-biomarker-of-treatment-success-after-liver-metastasis-ablation
#13
Francois Cornelis, Vlasios Storchios, Elena Violari, Constantinos T Sofocleous, Heiko Schoder, Jeremy C Durack, Robert H Siegelbaum, Majid Maybody, John Humm, Stephen B Solomon
UNLABELLED: The rationale of this study was to examine whether (18)F-FDG PET/CT and contrast-enhanced CT performed immediately after percutaneous ablation of liver metastases are predictors of local treatment failure at 1 y. METHODS: This Health Insurance Portability and Accountability Act-compliant, Institutional Review Board-approved retrospective study reviewed 25 PET/CT-guided thermal ablations performed from September 2011 to March 2013 on 21 patients (11 women and 10 men; mean age, 56...
July 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26718578/safety-and-immunologic-effects-of-high-vs-low-dose-cholecalciferol-in-multiple-sclerosis
#14
RANDOMIZED CONTROLLED TRIAL
Elias S Sotirchos, Pavan Bhargava, Christopher Eckstein, Keith Van Haren, Moira Baynes, Achilles Ntranos, Anne Gocke, Lawrence Steinman, Ellen M Mowry, Peter A Calabresi
OBJECTIVE: To study the safety profile and characterize the immunologic effects of high- vs low-dose cholecalciferol supplementation in patients with multiple sclerosis (MS). METHODS: In this double-blind, single-center randomized pilot study, 40 patients with relapsing-remitting MS were randomized to receive 10,400 IU or 800 IU cholecalciferol daily for 6 months. Assessments were performed at baseline and 3 and 6 months. RESULTS: Mean increase of 25-hydroxyvitamin D levels from baseline to final visit was larger in the high-dose group (34...
January 26, 2016: Neurology
https://www.readbyqxmd.com/read/26277696/radioembolization-as-a-salvage-therapy-for-heavily-pretreated-patients-with-colorectal-cancer-liver-metastases-factors-that-affect%C3%A2-outcomes
#15
Constantinos T Sofocleous, Elena G Violari, Vlasios S Sotirchos, Waleed Shady, Mithat Gonen, Neeta Pandit-Taskar, Elena N Petre, Lynn A Brody, William Alago, Richard K Do, Michael I D'Angelica, Joseph R Osborne, Neil H Segal, Jorge A Carrasquillo, Nancy E Kemeny
BACKGROUND: In this study we assessed the efficacy and factors that affect outcomes of radioembolization (RE) using yttrium-90 resin microspheres in patients with unresectable and chemorefractory colorectal cancer liver metastases (CLM). PATIENTS AND METHODS: After an institutional review board waiver of approval, a review of a Health Insurance Portability and Accountability Act-registered, prospectively created and maintained database was performed. Data on patient demographic and disease characteristics, RE treatment parameters, and additional treatments were evaluated for significance in predicting overall survival (OS) and liver progression-free survival (LPFS)...
December 2015: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/25609766/relationships-between-quantitative-spinal-cord-mri-and-retinal-layers-in-multiple-sclerosis
#16
Jiwon Oh, Elias S Sotirchos, Shiv Saidha, Anna Whetstone, Min Chen, Scott D Newsome, Kathy Zackowski, Laura J Balcer, Elliot Frohman, Jerry Prince, Marie Diener-West, Daniel S Reich, Peter A Calabresi
OBJECTIVE: To assess relationships between spinal cord MRI (SC-MRI) and retinal measures, and to evaluate whether these measures independently relate to clinical disability in multiple sclerosis (MS). METHODS: One hundred two patients with MS and 11 healthy controls underwent 3-tesla brain and cervical SC-MRI, which included standard T1- and T2-based sequences and diffusion-tensor and magnetization-transfer imaging, and optical coherence tomography with automated segmentation...
February 17, 2015: Neurology
https://www.readbyqxmd.com/read/25580316/safe-and-successful-yttrium-90-resin-microsphere-radioembolization-in-a-heavily-pretreated-patient-with-chemorefractory-colorectal-liver-metastases-after-biliary-stent-placement-above-the-papilla
#17
Vlasios S Sotirchos, Elena N Petre, Karen T Brown, Lynn A Brody, Michael I D'Angelica, Ronald P DeMatteo, Nancy E Kemeny, Constantinos T Sofocleous
We report a case of safe and successful yttrium-90 resin microsphere radioembolization in a patient with a long history of multiple recurrent colon cancer hepatic metastases progressing after hepatic resections, hepatic arterial chemotherapy, and multiple regimens of systemic chemotherapy. One month prior to radioembolization, a biliary stent was placed above the level of the ampulla to relieve tumor-related biliary obstruction and normalize bilirubin levels.
2014: Case Reports in Hepatology
https://www.readbyqxmd.com/read/25382184/retinal-damage-and-vision-loss-in-african-american-multiple-sclerosis-patients
#18
MULTICENTER STUDY
Dorlan J Kimbrough, Elias S Sotirchos, James A Wilson, Omar Al-Louzi, Amy Conger, Darrel Conger, Teresa C Frohman, Shiv Saidha, Ari J Green, Elliot M Frohman, Laura J Balcer, Peter A Calabresi
OBJECTIVE: To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients. METHODS: A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high- and low-contrast visual acuity (HCVA and LCVA) and high-definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self-identified AA and CA ancestry...
February 2015: Annals of Neurology
https://www.readbyqxmd.com/read/24893707/cerebrospinal-fluid-ceramides-from-patients-with-multiple-sclerosis-impair-neuronal-bioenergetics
#19
MULTICENTER STUDY
Oscar G Vidaurre, Jeffery D Haines, Ilana Katz Sand, Kadidia P Adula, Jimmy L Huynh, Corey A McGraw, Fan Zhang, Merina Varghese, Elias Sotirchos, Pavan Bhargava, Veera Venkata Ratnam Bandaru, Giulio Pasinetti, Weijia Zhang, Matilde Inglese, Peter A Calabresi, Gang Wu, Aaron E Miller, Norman J Haughey, Fred D Lublin, Patrizia Casaccia
Axonal damage is a prominent cause of disability and yet its pathogenesis is incompletely understood. Using a xenogeneic system, here we define the bioenergetic changes induced in rat neurons by exposure to cerebrospinal fluid samples from patients with multiple sclerosis compared to control subjects. A first discovery cohort of cerebrospinal fluid from 13 patients with multiple sclerosis and 10 control subjects showed that acute exposure to cerebrospinal fluid from patients with multiple sclerosis induced oxidative stress and decreased expression of neuroprotective genes, while increasing expression of genes involved in lipid signalling and in the response to oxidative stress...
August 2014: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/24593281/spinal-cord-normalization-in-multiple-sclerosis
#20
Jiwon Oh, Michaela Seigo, Shiv Saidha, Elias Sotirchos, Kathy Zackowski, Min Chen, Jerry Prince, Marie Diener-West, Peter A Calabresi, Daniel S Reich
BACKGROUND: Spinal cord (SC) pathology is common in multiple sclerosis (MS), and measures of SC-atrophy are increasingly utilized. Normalization reduces biological variation of structural measurements unrelated to disease, but optimal parameters for SC volume (SCV)-normalization remain unclear. Using a variety of normalization factors and clinical measures, we assessed the effect of SCV normalization on detecting group differences and clarifying clinical-radiological correlations in MS...
November 2014: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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