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Vogel, tiffany

Chase A Arbra, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Christian J Streck
BACKGROUND: Pediatric intraabdominal injuries (IAI) from blunt abdominal trauma (BAT) rarely require emergent intervention. For those children undergoing procedural intervention, our aim was to understand the timing and indications for operation and angiographic embolization. METHODS: We prospectively enrolled children <16 years following BAT at 14 Level-One Pediatric Trauma Centers over a 1-year period. Patients with IAI who received an intervention (IAI-I) were compared to those who did not receive an intervention using descriptive statistics and univariate analysis; p < 0...
April 27, 2017: Journal of Trauma and Acute Care Surgery
Tiffany Vogeler, Claire McClain, Kirk E Evoy
BACKGROUND: Tobacco is the leading cause of preventable death in the world. Current cessation medications include nicotine replacement therapy (NRT), varenicline, and bupropion, while combination therapy primarily entails NRT with either varenicline or bupropion. However, recent studies have examined varenicline and bupropion in combination. OBJECTIVES: A systematic review assessing the efficacy and safety of combination varenicline and bupropion was conducted. METHODS: PubMed and Clinicaltrials...
March 2016: American Journal of Drug and Alcohol Abuse
Anthony E Rizzardi, Nikolaus K Rosener, Joseph S Koopmeiners, Rachel Isaksson Vogel, Gregory J Metzger, Colleen L Forster, Lauren O Marston, Jessica R Tiffany, James B McCarthy, Eva A Turley, Christopher A Warlick, Jonathan C Henriksen, Stephen C Schmechel
BACKGROUND: Prognostic multibiomarker signatures in prostate cancer (PCa) may improve patient management and provide a bridge for developing novel therapeutics and imaging methods. Our objective was to evaluate the association between expression of 33 candidate protein biomarkers and time to biochemical failure (BF) after prostatectomy. METHODS: PCa tissue microarrays were constructed representing 160 patients for whom clinicopathologic features and follow-up data after surgery were available...
2014: BMC Cancer
Matthew L Maciejewski, Tiffany A Radcliff, William G Henderson, Diane Cowper Ripley, W Bruce Vogel, Elizabeth Regan, Evelyn Hutt
Veterans hospitalized for hip fracture repair may be discharged to one of several rehabilitation settings, but it is not known what factors influence postsurgical discharge setting. The purpose of the study was to examine the patient, facility, and market factors that influence the choice of postsurgical discharge setting. Using a retrospective cohort design, we linked 11,083 veterans who had hip fracture surgeries in a Department of Veterans Affairs (VA) hospital from 1998 to 2005 as assessed by the VA National Surgical Quality Improvement Program dataset with administrative data...
2013: Journal of Rehabilitation Research and Development
Elizabeth A Regan, Tiffany A Radcliff, William G Henderson, Diane C Cowper Ripley, Matthew L Maciejewski, W Bruce Vogel, Evelyn Hutt
UNLABELLED: Hip fractures in the elderly have high rates of mortality and perioperative complications. Both men and COPD patients have worse mortality and complications but this may be due to more co-morbid disease. We assessed mortality and complications in a large cohort (n = 12,646) of men undergoing hip fracture surgery within the Veteran's Health Affairs (VHA) to define the association of COPD to these outcomes after adjusting for other key factors. We looked for opportunities to improve outcomes for COPD patients...
February 2013: COPD
Jean J Latimer, Jennifer M Johnson, Crystal M Kelly, Tiffany D Miles, Kelly A Beaudry-Rodgers, Nancy A Lalanne, Victor G Vogel, Amal Kanbour-Shakir, Joseph L Kelley, Ronald R Johnson, Stephen G Grant
The molecular etiology of breast cancer has proven to be remarkably complex. Most individual oncogenes are disregulated in only approximately 30% of breast tumors, indicating that either very few molecular alterations are common to the majority of breast cancers, or that they have not yet been identified. In striking contrast, we now show that 19 of 19 stage I breast tumors tested with the functional unscheduled DNA synthesis assay exhibited a significant deficiency of DNA nucleotide excision repair (NER) capacity relative to normal epithelial tissue from disease-free controls (n = 23)...
December 14, 2010: Proceedings of the National Academy of Sciences of the United States of America
Anke Di, Takeshi Kawamura, Xiao-Pei Gao, Haiyang Tang, Evgeny Berdyshev, Stephen M Vogel, You-Yang Zhao, Tiffany Sharma, Kurt Bachmaier, Jingsong Xu, Asrar B Malik
The mechanism underlying the protective effect of sphingosine kinase 1 (SphK1) in inflammatory injury is not clear. We demonstrated using SphK1-null mice (SphK1(-/-)) the crucial role of SphK1 in suppressing lipopolysaccharide-induced neutrophil oxidant production and sequestration in lungs and mitigating lung inflammatory injury. This effect of SphK1 was independent of the production of sphingosine 1-phosphate, the product of SphK1 activity. The anti-inflammatory effect of SphK1 in the lipopolysaccharide model was mediated through SphK1 interaction with JNK...
May 21, 2010: Journal of Biological Chemistry
Xingwei Li, Anthony R Chianese, Tiffany Vogel, Robert H Crabtree
[reaction: see text] Iridium(III) hydrides prove to be air-stable active catalysts for intramolecular hydroalkoxylation and hydroamination of internal alkynes with proximate nucleophiles. The cyclization follows highly selective 6-endo-dig regiochemistry when regioselectivity is an issue.
November 24, 2005: Organic Letters
S Jones, C Vogel, A Arkhipov, L Fehrenbacher, P Eisenberg, B Cooper, S Honig, A Polli, F Whaley, E di Salle, J Tiffany, A Consonni, L Miller
PURPOSE: To assess the antitumor activity, safety, and hormone-suppressive effects of the irreversible aromatase inactivator, exemestane (Aromasin, Pharmacia & Upjohn, Kalamazoo, MI), administered as third-line hormone therapy to postmenopausal women with metastatic breast cancer that is refractory to tamoxifen and megestrol acetate. PATIENTS AND METHODS: Exemestane was administered at a dose of 25 mg/d orally until patients experienced disease progression. The efficacy and safety of exemestane were clinically and radiographically evaluated...
November 1999: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
S M Tiffany, D G Graham, F S Vogel, M W Cass, P W Jeffs
No abstract text is available yet for this article.
October 1978: Cancer Research
D G Graham, S M Tiffany, F S Vogel
The quinone intermediates resulting from tyrosinase-mediated oxidation of tyrosine were evaluated as sulfhydryl reagent inhibitors of purified calf thymus DNA polymerase alpha in order to determine which of these might be cytotoxic. Dopachrome and an oxidation product of 2,4,5-trihydroxyphenylalanine were relatively ineffective as inhibitors of DNA polymerase alpha. On the other hand, a dopaquinone analogue, 4-(2-N-acetylaminoethyl)-1,2-benzoquinone, synthesized from N-acetyl dopamine, was demonstrated to have marked affinity for this sulfhydryl enzyme...
February 1978: Journal of Investigative Dermatology
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