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Donald M Fox
BACKGROUND: Orbital volume loss, early or late, is common after placement of an orbital implant or dermis fat graft, and there is currently no satisfactory long-lasting solution. Hyaluronic fillers are relatively easy to administer but are prone to migration and are temporary. Cannula-based orbital fat grafting has not gained the status of standard of care because of perceived low likelihood of success in the near term. This paper describes a technique for fat volume augmentation, its rationale, long-term follow-up, and a description of a complication unique to fat grafting in the orbit...
September 21, 2018: Aesthetic Plastic Surgery
Chih-Cheng Wu, Li-Jing Chen, Mu-Yang Hsieh, Chien-Ming Lo, Ming-Hsien Lin, Hsiao-En Tsai, Hsiang-Lin Song, Jeng-Jiann Chiu
BACKGROUND AND OBJECTIVES: There is increasing evidence that microRNAs (miRNAs) play crucial roles in the regulation of neointima formation. However, the translational evidence of the role of miRNAs in dialysis vascular access is limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: miRNA expression in tissues was assessed by using venous tissues harvested from ten patients on dialysis who received revision or removal surgery, and ten patients who were predialysis and received creation surgery of arteriovenous fistulas served as controls...
September 21, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray, Yvonne L Hauck
BACKGROUND: Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with gynaecological cancer are not being met and provision of holistic care is a priority area for action. Knowledge on gynaecological cancer supportive care needs is limited, specifically comparison of needs and cancer gynaecological subtype. Our aim was to identify supportive care needs of Western Australian women experiencing gynaecological cancer, their satisfaction with help and explore associations between participant's demographic characteristics and identified needs...
September 21, 2018: BMC Cancer
Thibaut Demaneuf, Zoe Aitken, Amalia Karahalios, Teng Ieng Leong, Alysha M De Livera, George A Jelinek, Tracey J Weiland, Claudia H Marck
OBJECTIVE: To systematically review the evidence of the effect of exercise compared to passive control on pain in people with multiple sclerosis. DATA SOURCE AND STUDY SELECTION: Five electronic databases were searched for randomized controlled trials published up to March 2017 that recruited people with multiple sclerosis where exercise was the intervention and pain was an outcome. (PROSPERO registration number CRD42017060489). STATISTICAL ANALYSIS: A random-effects meta-analysis was conducted to estimate the standardized mean difference of the effect of exercise on pain between treatment and control groups...
September 18, 2018: Archives of Physical Medicine and Rehabilitation
Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M Koutelidakis, Michael Bauer, Evangelos J Giamarellos-Bourboulis, Iraklis Tsangaris
High mobility group box 1 (HMGB1) is released from macrophages as a late biomarker of sepsis. Conditions associated with pre-existing macrophage activation may modify HMGB1 expression. This study aimed to assess the impact of HMGB1 kinetics on 28-day mortality. In a sub-study of a previous randomized clinical trial among patients with SIRS and Gram-negative infections, patients were classified in early and late HMGB1 peak groups. Serial measurements of HMGB1, ferritin and interferon-gamma (IFNγ) were performed in all available sera...
September 19, 2018: Shock
Wafik Said Bahnasy, Yasser Abo Elfotoh El-Heneedy, Ehab Ahmed Shawky El-Seidy, Nema Ata Allah Labib, Ibrahim Salah Eldeen Ibrahim
Background: Disordered sleep breathing is a common complication of diabetic peripheral neuropathy (DPN) manifested by excessive daytime sleepiness, morning headache, morning dizziness, cognitive decline, and mood changes. Methods: This study was performed on 30 non-obese type 2 diabetic patients; 20 with clinically evident DPN and 10 without. Ten age-, sex-, and body mass index-matched healthy control subjects were also included. Patients and control were subjected to history taking, neurological examination, glycated hemoglobin, and clinical assessment of the sensori-motor manifestations by the neuropathy symptom score and neuropathy disability score...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
Jozo Grgic, Brad J Schoenfeld, Christopher Latella
OBJECTIVES: Current reviews and position stands on resistance training (RT) frequency and associated muscular hypertrophy are based on limited evidence holding implications for practical application and program design. Considering that several recent studies have shed new light on this topic, the present paper aimed to collate the available evidence on RT frequency and the associated effect on muscular hypertrophy. DESIGN: Review article. METHODS: Articles for this review were obtained through searches of PubMed/MEDLINE, Scopus, and SPORTDiscus...
September 13, 2018: Journal of Science and Medicine in Sport
Danielle Y Ponzio, Yu-Fen Chiu, Anthony Salvatore, Yuo-Yu Lee, Stephen Lyman, Russell E Windsor
This article was updated on September 19, 2018, because of a previous error. On page 1546, in the section titled "Discussion," the sentence that had read "Although a significant improvement was found in the vast majority of the inactive group, surprisingly, a majority of the active group (72.7%) reported a decrease in their activity levels below their baseline at 5 to 10 years postoperatively." now reads "Although a significant improvement was found in the vast majority of the inactive group, surprisingly, a majority of the active group (72...
September 19, 2018: Journal of Bone and Joint Surgery. American Volume
Leigh Ann Difusco, Stephanie M Helman
Pediatric patients are unique both in their diagnosis and clinical presentation before implantation of a ventricular assist device (VAD) and in their driveline site characteristics post-implant. There is limited evidence in scholarly literature that describes complications of pediatric VAD driveline sites or approaches by which to manage them. The Cardiac Center at The Children's Hospital of Philadelphia (CHOP) follows a standard of care for HeartWare VAD (HVAD) dressing changes in the inpatient setting with the goal of transitioning patients to weekly dressing changes by the time they are discharged to home...
September 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Zahra Azarbayjani, Tahereh Sadat Jafarzadeh Kashi, Yasaman Erfan, Nasim Chiniforush, Vahid Rakhshan
Background: Evidence on the protecting effect of laser on bleached enamel is scarce and controversial. Therefore, we aimed to test for the first time whether different wavelengths of diode laser (810 and 980 nm) can prevent enamel surface corrosion. We also tested for the first time whether such therapeutic effects of laser are limited to specific "laser-activated" bleaching gels or both conventional and laser-activated gels. Materials and Methods: In this qualitative experimental study, ten intact human teeth were randomly assigned to five Groups...
September 2018: Dental Research Journal
Jone Bjornestad, Marius Veseth, Larry Davidson, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Ingrid Melle, Wenche Ten Velden Hegelstad
Background: Despite the evidence of the importance of including service users' views on psychotherapy after psychosis, there is a paucity of research investigating impact on full recovery. Objectives: To explore what fully recovered service users found to be the working ingredients of psychotherapy in the recovery process after psychosis. Materials and Methods: The study was designed as a phenomenological investigation with thematic analysis as the practical tool for analysis. Twenty fully recovered service users were interviewed...
2018: Frontiers in Psychology
Sarah L Platt, Amit Patel, Pauline J Humphrey, Hoda Al-Booz, Jo Bailey
The standard treatment for locally advanced cervical cancer is chemo-radiotherapy. The presence of the residual disease after treatment is directly related to the relapse risk and to poor survival. There is a lack of consensus on the role of a subsequent surgery due to morbidity concerns. Oncological and peri-operative outcomes of completion surgery for cervical cancer were reviewed by retrospective descriptive analysis of the eligible cases between March 2012 and March 2016. Fifteen women were identified. Ten (66...
September 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Chensheng Ma, Ruth Chau Ting Chan, Chris Tsz-Leung Chan, Allen Ka-Wa Wong, Bowie Po-Yee Chung, Wai-Ming Kwok
I-motifs are tetraplex DNAs known to be stable at acidic pH. The structure of i-motifs is important in DNA nanotechnology while i-motif forming sequences with consecutive cytosines (Cs) are abundant throughout the human genome. There is however little information on structure of C-rich DNAs at the physiologically relevant neutral condition. The electron dynamics of i-motifs, crucial to both the biology and material applications, also remains largely unexplored. In this work, we report a combined femtosecond and nanosecond broadband time-resolved fluorescence (TRF) and steady state fluorescence investigation on homo-oligomer dC20, a human telomeric sequence (HTS) 5'-dC3(TA2C3)3 and its analog performed with different excitation at both acidic and neutral pH...
September 19, 2018: Chemistry, An Asian Journal
Celeste Ruiz de Arcaute, Marcelo L Larramendy, Sonia Soloneski
Long-term genotoxic effects of two auxinic herbicide formulations, namely, the 58.4% 2,4-dichlorophenoxyacetic acid (2,4-D)-based DMA® and the 57.7% dicamba (DIC)-based Banvel® were evaluated on Cnesterodon decemmaculatus. Primary DNA lesions were analyzed by the single-cell gel electrophoresis methodology. Two sublethal concentrations were tested for each herbicide corresponding to 2.5% and 5% of the LC5096h values. Accordingly, fish were exposed to 25.2 and 50.4 mg/L or 41 and 82 mg/L for 2,4-D and DIC, respectively...
September 8, 2018: Environmental Pollution
Chelsea A Obourn, John L Frodel
Facelifts remain a critical part of a facial plastic surgeon's cosmetic practice. Techniques continue to evolve, while at the same time patients demand less invasive procedures with less morbidity. The authors present a facelift plication technique using wide purse-string sutures placed into the superficial musculoaponeurotic system and platysma. This is a retrospective review with a level of evidence 3 set at a medical spa and tertiary referral center designed to assess a purse-string suture technique using an inner followed by an outer purse-string, with refinements being made during the timeframe of the review...
September 18, 2018: Facial Plastic Surgery: FPS
Ariel Porcalla, Nella Barshteyn, Scott Snyder, Mondira Bhattacharya
BACKGROUND: Drug-drug interaction (DDIs) are evaluated using pharmacokinetic (PK) simulation models, clinical studies, and scientific publications throughout drug development. DDIs with Norvir (ritonavir) and combination products (eg, Kaletra [lopinavir/ritonavir]) containing ritonavir as a PK enhancer are relevant, because these drugs could affect exposures of CYP3A4 substrates. Application of algorithms proactively identified recently approved drugs, which potentially cause adverse outcomes when given with drugs containing ritonavir...
November 2017: Therapeutic Innovation & Regulatory Science
Miguel M Cabada, Maria Luisa Morales, Camille M Webb, Logan Yang, Chelsey A Bravenec, Martha Lopez, Ruben Bascope, A Clinton White, Eduardo Gotuzzo
Fasciola hepatica is the most widely distributed trematode-affecting humans. The Andes Mountains are highly endemic for fascioliasis. We report results of a cross-sectional study evaluating the epidemiology of Fasciola among children in 26 agricultural communities in the Cusco region of Peru. Children 3 to 16 years old were enrolled in preschools and schools. Blood from participants was tested for complete blood counts, transaminases, and Fasciola antibodies. Stool samples were tested for Fasciola and other parasites...
September 17, 2018: American Journal of Tropical Medicine and Hygiene
Bernard Y Kim, Wei Xinzeng, Sorel Fitz-Gibbon, Kirk E Lohmueller, Joaquín Ortego, Paul F Gugger, Victoria L Sork
A long-term debate in evolutionary biology is the extent to which reproductive isolation is a necessary element of speciation. Hybridizing plants in general are cited as evidence against this notion and oaks specifically have been used as the classic example of species maintenance without reproductive isolation. Here, we use thousands of SNPs generated by RAD sequencing to describe the phylogeny of a set of sympatric white oak species in California and then test whether these species exhibit pervasive interspecific gene exchange...
September 17, 2018: Molecular Ecology
Jacob Y Cao, Kathryn M Wales, Rachael Cordina, Edmund M T Lau, David S Celermajer
BACKGROUND: Pulmonary hypertension complicating left heart disease (PH-LHD) is the most common cause of PH. Off-label use of pulmonary arterial hypertension (PAH) medications for PH-LHD is prevalent, despite a lack of clinical data supporting their use. METHODS: A systematic review and meta-analysis was performed. Comprehensive search of all available literature to date identified ten randomised, placebo controlled trials comprising 439 treated (Phosphodiesterase 5 inhibitors: n = 206; guanylate cyclase stimulators: n = 132; endothelin receptor antagonists: n = 101) and 338 placebo patients...
September 12, 2018: International Journal of Cardiology
Kosuke Niitsu, Michael J Rice, Julia F Houfek, Scott F Stoltenberg, Kevin A Kupzyk, Cecilia R Barron
When exposed to adversity, some individuals are at an increased risk of posttraumatic stress disorder, experiencing persistent biopsychosocial disturbances, whereas others adapt well, described as resilience. Resilience is a complex biopsychosocial phenomenon conceptualized as adaptation to adversity influenced by an individual's genetic variants, epistasis, epigenetics, and gene-by-environment interactions. Studies on psychological resilience have focused on behavioral and psychosocial variables with far less examination of the genetic contributions...
September 17, 2018: Biological Research for Nursing
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