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https://www.readbyqxmd.com/read/30419516/from-next-generation-sequencing-to-now-generation-sequencing-in-forensics
#1
REVIEW
Peter de Knijff
In contrast to genetic diagnostic disciplines such as Oncogenetics and Cinical Genetics, where worldwide, since 2010, tens of thousands of DNA samples are routinely screened annually using either targeted genome sequencing or whole genome sequencing using massively parallel sequencing (MPS), the forensic use of MPS is still far from being a routine diagnostic tool. This perspectives focusses on issues that are essential in order to fully understand (i) why MPS of short tandem repeats (STRs) is very different from the capillary electrophoresis (CE) based genotyping of STRs, (ii) what we, DNA experts, should know before explaining MPS-based evidence in court, and (iii) what information should be present in a forensic investigation report that is MPS-based...
November 3, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/30417704/ten-years-of-hpv-vaccination-in-the-netherlands-current-evidence-and-future-challenges-in-hpv-related-disease-prevention
#2
V Qendri, T M Schurink-van 't Klooster, J A Bogaards, J Berkhof
Girls-only vaccination against human papillomavirus (HPV) type 16 and 18 was implemented in the Netherlands in 2009. Despite the evidence on the efficacy against precancerous lesions, cross-protection induced by the vaccine and a greater potential for cancer prevention than cervical cancer only, vaccine coverage in the girls-only program has remained below target levels. Areas covered: In this paper, we review the literature from the Netherlands on the effectiveness and cost-effectiveness of HPV vaccination since vaccine introduction, give an account of the coverage, safety and effectiveness of HPV vaccination as has been reported in the Dutch surveillance program and discuss challenges of the current HPV vaccination program...
November 10, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/30417173/analysis-of-evidence-for-the-combination-of-pro-dopamine-regulator-kb220pam-and-naltrexone-to-prevent-opioid-use-disorder-relapse
#3
Kenneth Blum, Edward J Modestino, Rajendra D Badgaiyan, David Baron, Panayotis K Thanos, Igor Elman, David Siwicki, Marcelo Febo, Mark S Gold
Blum's laboratory first showed the benefits of naloxone or narcotic antagonists in the treatment of alcohol dependence. This seminal work published in Nature in the early 70's, in conjunction with many other studies, later served as the basis for the development of the narcotic antagonist (NTX) now used to treat both alcohol and opioid dependence. In 2006 an extended-release injectable of Naltrexone (XR-NTX) was approved by the FDA. Naltrexone is a relatively weak antagonist of κ- and δ-receptors and is also a potent μ-receptor antagonist...
August 2018: EC psychology and psychiatry
https://www.readbyqxmd.com/read/30416677/chronic-heart-failure-is-characterized-by-altered-mitochondrial-function-and-structure-in-circulating-leucocytes
#4
Roberta Coluccia, Salvatore Raffa, Danilo Ranieri, Andrea Micaloni, Sabatino Valente, Gerardo Salerno, Cristina Scrofani, Marco Testa, Giovanna Gallo, Erika Pagannone, Maria Rosaria Torrisi, Massimo Volpe, Speranza Rubattu
Oxidative stress is currently viewed as a key factor in the genesis and progression of Heart Failure (HF). The aim of this study was to characterize the mitochondrial changes linked to oxidative stress generation in circulating peripheral blood mononuclear cells isolated from chronic HF patients (HF_PBMCs) in order to highlight the involvement of mitochondrial dysfunction in the pathophysiology of HF. To assess the production of reactive oxygen species (ROS), mitochondrial function and ultrastructure and the mitophagic flux in circulating PBMCs we enrolled 15 patients with HF and a control group of ten healthy subjects...
October 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/30415757/olive-oil-consumption-and-human-health-a-narrative-review
#5
REVIEW
Alexandra Foscolou, Elena Critselis, Demosthenes Panagiotakos
The potential health benefits of olive oil consumption, particularly within the context of the Mediterranean diet, have been extensively investigated. However, its specific health benefits remain to be confirmed. The aim of the present work is to review the scientific evidence regarding the specific impact of olive oil consumption on human health, including the prevention of cardiovascular disease, cancers, and diabetes mellitus. Ten related meta-analyses were reviewed to this effect. Olive oil consumption was found to be beneficial for several chronic non-communicable diseases (e...
December 2018: Maturitas
https://www.readbyqxmd.com/read/30412330/a-systematic-review-to-assess-the-methodological-quality-of-studies-on-measurement-properties-for-caries-risk-assessment-tools-for-young-children
#6
REVIEW
Bradley Christian, Rebecca Armstrong, Hanny Calache, Lauren Carpenter, Lisa Gibbs, Mark Gussy
BACKGROUND: At present, there are numerous caries risk assessment tools (CRATs) being promoted for disease management. However, the evidence to inform CRAT selection is unclear. AIM: This review aimed to assess the strength of evidence to inform the selection of CRATs for children ages 6 years and less. DESIGN: MEDLINE was the principal search database for this review. Other key databases, the reference lists of included articles, known cariology literature and experts were also consulted...
November 9, 2018: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/30411186/post-extrasystolic-characteristics-in-the-arterial-blood-pressure-waveform-are-associated-with-right-ventricular-dysfunction-in-intensive-care-patients
#7
Simon Tilma Vistisen, Benjamin Moody, Leo Anthony Celi, Christina Chen
Right ventricular dysfunction (RVD) is associated with end-organ dysfunction and mortality, but has been an overlooked condition in the ICU. We hypothesized that analysis of the arterial waveform in the presence of ventricular extrasystoles could differentiate patients with RVD from patients with a normally functioning right ventricle, because the 2nd and 3rd post-ectopic beat could reflect right ventricular state (pulmonary transit time) during the preceding ectopy. We retrospectively identified patients with echocardiographic evidence of moderate-to-severe RVD and patients with a normal functioning right ventricle (control) from the MIMIC database...
November 8, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/30411137/-skin-cancer-screening-in-germany-review-after-ten-years
#8
REVIEW
Joachim Hübner, Nora Eisemann, Alicia Brunßen, Alexander Katalinic
In 2008, a nationwide population-based skin cancer screening program was introduced in Germany. Its potential to reduce the skin cancer-related burden of disease is the subject of a controversial debate. This article gives an overview on the epidemiology of cutaneous melanoma of the skin and nonmelanoma skin cancer, on the history and practice of the current program, and appraises the evidence of screening for skin cancer based on a selective search for literature and data.The incidence of skin cancer has increased markedly throughout the last decades...
November 8, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/30410634/intravenous-immunoglobulin-therapy-administered-early-after-narcolepsy-type-1-onset-in-three-patients-evaluated-by-clinical-and-polysomnographic-follow-up
#9
Elisabeth Ruppert, Hélène Zagala, Juliette Chambe, Henri Comtet, Ulker Kilic-Huck, François Lefebvre, Marc Bataillard, Carmen Schroder, Laurent Calvel, Patrice Bourgin
Narcolepsy type 1 is a rare disabling sleep disorder mainly characterized by excessive daytime sleepiness and cataplexy, an emotion-triggered sudden loss of muscle tone. Patients have a selective degeneration of hypocretin-producing neurons in the dorsolateral posterior hypothalamus with growing evidence supporting the hypothesis of an autoimmune mechanism. Few case studies that reported intravenous immunoglobulin therapy (IVIg) suggest the efficacy of IVIg when administered early after disease onset, but the results are controversial...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/30410543/environmental-and-life-style-related-risk-factors-for-sinonasal-and-nasopharyngeal-malignancies-among-a-prospective-cohort-in-jos-nigeria
#10
Adeyi A Adoga, Daniel D Kokong, Tonga L Nimkur, Nuhu D Ma'an
Background: Worldwide evidence indicates that environmental and life-style related factors are associated with increased risk for cancers in the head and neck region. We aim to study the association between these risk factors and cancers in the sinonasal and nasopharyngeal regions in our environment. Methods: Longitudinal prospective cohort study at the Jos University Teaching Hospital, Jos, Nigeria. Risk exposures were classified based on the International Agency for the Research on Cancer (IARC) classification of suspected carcinogens...
2018: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/30409109/migraine-induction-with-calcitonin-gene-related-peptide-in-patients-from-erenumab-trials
#11
Casper Emil Christensen, Samaira Younis, Marie Deen, Sabrina Khan, Hashmat Ghanizada, Messoud Ashina
BACKGROUND: Migraine prevention with erenumab and migraine induction by calcitonin gene-related peptide (CGRP) both carry notable individual variance. We wanted to explore a possible association between individual efficacy of anti-CGRP treatment and susceptibility to migraine induction by CGRP. METHODS: Thirteen migraine patients, previously enrolled in erenumab anti-CGRP receptor monoclonal antibody trials, received CGRP in a double-blind, placebo-controlled, randomized cross-over design to investigate their susceptibility to migraine induction...
November 8, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30408889/adverse-impact-of-nocturnal-transportation-noise-on-glucose-regulation-in-healthy-young-adults-effect-of-different-noise-scenarios
#12
Laurie Thiesse, Franziska Rudzik, Karine Spiegel, Rachel Leproult, Reto Pieren, Jean Marc Wunderli, Maria Foraster, Harris Héritier, Ikenna C Eze, Martin Meyer, Danielle Vienneau, Mark Brink, Nicole Probst-Hensch, Martin Röösli, Christian Cajochen
BACKGROUND: Epidemiological evidence indicates an association between transportation noise exposure and a higher risk of developing type 2 diabetes. Sleep disturbances are thought to be one of the mechanisms as it is well established that a few nights of short or poor sleep impair glucose tolerance and insulin sensitivity in healthy good sleepers. OBJECTIVES: The present study aimed to determine the extent to which exposure to nocturnal transportation noise affects glucose metabolism, and whether it is related to noise-induced sleep alterations...
December 2018: Environment International
https://www.readbyqxmd.com/read/30407616/cannabis-for-the-treatment-of-crohn-s-disease
#13
REVIEW
Tahir S Kafil, Tran M Nguyen, John K MacDonald, Nilesh Chande
BACKGROUND: Crohn's disease (CD) is a chronic immune-mediated condition of transmural inflammation in the gastrointestinal tract, associated with significant morbidity and decreased quality of life. The endocannabinoid system provides a potential therapeutic target for cannabis and cannabinoids and animal models have shown benefit in decreasing inflammation. However, there is also evidence to suggest transient adverse events such as weakness, dizziness and diarrhea, and an increased risk of surgery in people with CD who use cannabis...
November 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30407044/sleepy-sluggish-worried-or-down-the-distinction-between-self-reported-sluggish-cognitive-tempo-daytime-sleepiness-and-internalizing-symptoms-in-youth-with-attention-deficit-hyperactivity-disorder
#14
Zoe R Smith, Hana-May Eadeh, Rosanna P Breaux, Joshua M Langberg
Sluggish cognitive tempo (SCT) consists of symptoms of slowness, sluggishness, daydreaming, and low motivation. SCT has been linked to attention-deficit/hyperactivity disorder (ADHD), internalizing symptoms, and daytime sleepiness. Although there is clear evidence that SCT and ADHD symptoms are distinct constructs, the distinction between SCT, anxiety/depression, and daytime sleepiness is less clear. Prior research has largely relied upon parent-report to evaluate potential overlap between SCT, sleep, and anxiety/depression, despite best practice suggesting that self-report should be used to assess internalizing symptoms...
November 8, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/30406640/rutosides-for-treatment-of-post-thrombotic-syndrome
#15
REVIEW
Joanne R Morling, Cathryn Broderick, Su Ern Yeoh, Dinanda N Kolbach
BACKGROUND: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. Rutosides are a group of compounds derived from horse chestnut (Aesculus hippocastanum), a traditional herbal remedy for treating oedema formation in chronic venous insufficiency (CVI). However, it is not known whether rutosides are effective and safe in the treatment of PTS...
November 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30405698/dynamic-changes-in-the-global-micrornaome-and-transcriptome-identify-key-nodes-associated-with-ovarian-development-in-chickens
#16
Wenwen Wang, Keliang Wu, Meiting Jia, Shuhong Sun, Li Kang, Qin Zhang, Hui Tang
The analysis of gene expression patterns during ovarian follicle development will advance our understanding of avian reproductive physiology and make it possible to improve laying performance. To gain insight into the molecular regulation of ovarian development, a systematic profiling of miRNAs and mRNAs at four key stages was conducted, using ovarian tissues from hens at 60 days of age (A), 100 days (B), 140 days-not yet laying (C), and 140 days-laying (D). Comparisons of consecutive stages yielded 73 differentially expressed miRNAs (DEMs) (14 for B vs...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30403822/does-paid-vacation-leave-protect-against-depression-among-working-americans-a-national-longitudinal-fixed-effects-analysis
#17
Daniel Kim
Objectives The United States is the only advanced economy globally that does not guarantee its workers paid vacation leave. Although empirical studies have linked paid vacation leave to happiness and stress, no study has investigated the association between paid vacation leave and depression. Using a nationally-representative longitudinal sample of 3380 working men and women aged 45-52 years from the National Longitudinal Survey of Youth 1979, this study explored whether paid vacation leave may protect against depression...
November 7, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/30403731/adolescents-have-unfavorable-opinions-of-adolescents-who-use-e-cigarettes
#18
Karma McKelvey, Lucy Popova, Jessica K Pepper, Noel T Brewer, Bonnie Halpern-Felsher
INTRODUCTION: While evidence suggests positive opinions of smokers are associated with tobacco use, research exploring adolescents' opinions of e-cigarette users is nascent. We hypothesized that adolescents harbor positive opinions of e-cigarette users, and that these opinions will be more positive among adolescents willing to try or who have used e-cigarettes. METHODS: Participants were 578 U.S. adolescents (ages 14 to 20) recruited from ten California schools...
2018: PloS One
https://www.readbyqxmd.com/read/30402136/does-electroacupuncture-treatment-reduce-pain-and-change-quantitative-sensory-testing-responses-in-patients-with-chronic-nonspecific-low-back-pain-a-randomized-controlled-clinical-trial
#19
Paula M S Leite, Andreza R C Mendonça, Leonardo Y S Maciel, Maurício L Poderoso-Neto, Carla C A Araujo, Hilda C J Góis, Jérsica H S Souza, Josimari M DeSantana
Chronic nonspecific low back pain is common and one of the most disabling conditions in the world. There is moderate evidence that chronic low back pain patients present altered functional connectivity in areas related to pain processing. Quantitative sensory testing is a way of clinical measure of these alterations. Although there is not enough evidence, there are some reports that electroacupuncture is supposedly more effective in relieving pain than acupuncture because the addition of electric current could optimize the effects of traditional technique...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30401730/dietary-protein-intake-and-risk-of-ovarian-cancer-evidence-from-a-meta-analysis-of-observational-studies
#20
Yanyang Pang, Wu Wang
The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of this study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Science from inception to June 2018. Two authors independently selected studies, extracted data and assessed risk of bias. RR and 95%CI were calculated for relationship between the dietary protein intake and ovarian cancer risk using a random-effects model...
November 6, 2018: Bioscience Reports
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