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https://www.readbyqxmd.com/read/28944471/a-composite-of-exhaled-ltb4-lxa4-feno-and-fev1-as-an-asthma-classification-ratio-characterizes-childhood-asthma
#1
Li-Chen Chen, Hsu-Min Tseng, Ming-Ling Kuo, Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Ai-Hsuan Wu, Jing-Long Huang, Shau-Ku Huang
BACKGROUND: Aberrant generation of eicosanoids is associated with asthma, but the evidence remains incomplete and its potential utility as biomarkers is unclear. Major eicosanoids in exhaled breath condensates (EBCs) were assessed as candidate markers for childhood asthma. METHODS: Ten exhaled eicosanoid species was evaluated using ELISA in the discovery phase, followed by prediction model-building and validation phases. RESULTS: Exhaled LTB4 , LTE4 , PGE2 and LXA4 showed significant difference between asthmatics (N=60) and controls (N=20)...
September 25, 2017: Allergy
https://www.readbyqxmd.com/read/28943712/bringing-alcohol-treatment-to-driving-under-the-influence-programs-perceptions-from-first-time-offenders
#2
Karen Chan Osilla, Magdalena Kulesza, Jeanne Miranda
Alcohol use disorders (AUDs) are common among first-time driving under the influence (DUI) offenders. Individuals with a DUI arrest may attend a DUI alcohol education program for license reinstatement. We evaluated the acceptability of cognitive behavioral treatment (CBT) for AUDs adapted for DUI programs. Participants (N=35) were enrolled in one of two DUI programs in Los Angeles and were an average of 34.5 (SD=11.9) years old; 66% male; 37.1% African American, 34.2% Hispanic/Latino(a), and 20% non-Hispanic White...
2017: Alcoholism Treatment Quarterly
https://www.readbyqxmd.com/read/28943040/treatment-of-musculo-skeletal-pain-in-haemophilia
#3
REVIEW
E Carlos Rodriguez-Merchan
Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of F VIII/IX. In acute haemarthroses pain treatment must continue until total disappearance (checked by ultrasonography) and include haematologic treatment, short-term rest of the involved joint, cryotherapy, joint aspiration and analgesic medication (paracetamol in mild pain, metamizole for more intense pain, and in a few precise patients, soft opioids such as codeine or tramadol)...
September 19, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28942855/a-systematic-review-and-meta-analysis-of-factors-for-delirium-in-vascular-surgical-patients
#4
REVIEW
Christopher Oldroyd, Anna F M Scholz, Robert J Hinchliffe, Kathryn McCarthy, Jonathan Hewitt, Terrence J Quinn
BACKGROUND: Delirium is a common syndrome responsible for a large burden of morbidity and mortality. In surgical settings, research into risk factors for postoperative delirium has largely focused on elective orthopedic patients. We performed a systematic review and meta-analysis to evaluate the evidence surrounding risk factors for delirium in vascular surgical populations. METHODS: Two independent reviewers searched five databases (MEDLINE, Web of Science, Embase, Cumulative Index to Nursing and Allied Health Literature, and PsycINFO) from January 1987 to December 2015...
October 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942139/computer-technologies-to-integrate-medical-treatments-to-manage-multimorbidity
#5
REVIEW
David Riaño, Wilfrido Ortega
The high prevalence of multimorbid cases is a challenge for Health-Care Systems today. Clinical practice guidelines are the means to register and transmit the available evidence-based medical knowledge concerning concrete diseases. Several computer languages have been defined to represent this knowledge in a way that computers could use to help physicians in the daily practice of medicine. The generation of guidelines for all possible multimorbidities entails several issues that are difficult to address. Consequently, numerous medical informatics technologies have appeared merging computer information structures in a way that the treatment knowledge about single diseases could be combined in order to deliver health-care to patients suffering from multimorbidity...
September 20, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28942118/carpal-tunnel-syndrome-effectiveness-of-physical-therapy-and-electrophysical-modalities-an-updated-systematic-review-of-randomized-controlled-trials
#6
REVIEW
Bionka M A Huisstede, Peter Hoogvliet, Thierry P C Franke, Manon S Randsdorp, Bart W Koes
OBJECTIVE: To review scientific literature studying the effectiveness of physical therapy and electrophysical modalities for carpal tunnel syndrome (CTS). DATA SOURCES: The Cochrane Library, PubMed, EMBASE, CINAHL, and PEDro. STUDY SELECTION: Two reviewers independently applied the inclusion criteria to select potential eligible studies. DATA EXTRACTION: Two reviewers independently extracted the data and assessed the methodological quality using the Cochrane Risk of Bias Tool...
September 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28941915/natural-history-of-complex-renal-cysts-clinical-evidence-supporting-active-surveillance
#7
Thenappan Chandrasekar, Ardalan E Ahmad, Kamel Fadaak, Kartik Jhaveri, Jaimin R Bhatt, Michael A S Jewett, Antonio Finelli
PURPOSE: To evaluate intervention rates, progression and cancer-specific survival outcomes of patients with complex renal cysts in a single center experience. MATERIALS AND METHODS: A radiology data-mining system (Montage; Montage Healthcare Systems, Philadelphia, PA, USA) was used to retrospectively identify all reported cases of "complex renal cyst" in our institution (2001-2013). Primary end points were overall (OS) and cancer specific survival (CSS). Secondary endpoints included radiographic progression and upgrading, clinical progression, and final histology on surgical pathology...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28940568/serum-il-17-in-patients-with-erythema-multiforme-or-stevens-johnson-syndrome-toxic-epidermal-necrolysis-drug-reaction-and-correlation-with-disease-severity
#8
H Morsy, E A Taha, D A Nigm, R Shahin, E M K Youssef
BACKGROUND: There is strong evidence that drug-induced cutaneous eruptions have an immunological component. Interleukin (IL)-17, a proinflammatory cytokine that is predominantly produced by T helper 17 cells, has been linked to various autoimmune and inflammatory diseases. AIM: To measure serum IL-17 levels in patients with cutaneous drug reactions [erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)] in order to study the associations between IL-17 and disease severity...
September 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28940106/en-bloc-endoscopic-mucosal-resection-is-equally-effective-for-sessile-serrated-polyps-and-conventional-adenomas
#9
Amol Agarwal, Sidyarth Garimall, Frank I Scott, Nuzhat A Ahmad, Michael L Kochman, Gregory G Ginsberg, Vinay Chandrasekhara
BACKGROUND: Sessile serrated polyps (SSPs) are associated with higher rates of incomplete resection compared to conventional adenomas after traditional snare polypectomy. Outcomes after endoscopic mucosal resection (EMR) are less established. The aim of this study was to evaluate the rate of residual neoplasia at surveillance colonoscopy for SSPs compared to conventional adenomas ≥ 10 mm after en bloc EMR. METHODS: Retrospective cohort study of consecutive patients referred for EMR of a colonic lesion ≥ 10 mm from 2005 to 2013...
September 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28939291/scalp-hypothermia-for-preventing-alopecia-during-chemotherapy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Hope S Rugo, Jeffrey Voigt
BACKGROUND: Alopecia is a side effect of chemotherapy and affects a patient's quality of life. Cooling the scalp during chemotherapy might reduce alopecia. The objective of this systematic and meta-analysis was to examine the effects of scalp cooling on the end point of alopecia in randomized controlled trials. MATERIALS AND METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Electronic searches of databases were undertaken through February 2017...
August 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28938645/sex-specific-association-of-sh2b3-and-smarca4-polymorphisms-with-coronary-artery-disease-susceptibility
#11
Yuqiang Ji, Yanbin Song, Qingwen Wang, Pengcheng Xu, Zhao Zhao, Xia Li, Nan Wang, Tianbo Jin, Chao Chen
To determine whether sex differences affect the association between genetic polymorphisms and coronary artery disease (CAD) in the Chinese Han population, we conducted a study comparing the frequency of SH2B3 and SMARCA4 variants in 456 CAD patients (291 men, 165 women) and 685 age-matched controls (385 men, 300 women). Ten single nucleotide polymorphisms (SNPs) in SH2B3 and SMARCA4 were genotyped using MassARRAY technology. Allelic and genotypic models and haplotype frequencies were compared between groups...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938420/bone-structural-characteristics-and-response-to-bisphosphonate-treatment-in-children-with-hajdu-cheney-syndrome
#12
Sophia Sakka, Rachel I Gafni, Justin H Davies, Bart Clarke, Peter Tebben, Mark Samuels, Vrinda Saraff, Klaus Klaushofer, Nadja Fratzl-Zelman, Paul Roschger, Frank Rauch, Wolfgang Högler
Context: Hajdu-Cheney syndrome (HJCYS) is a rare, multisystem, bone disease caused by heterozygous mutations in the NOTCH2 gene. Histomorphometric and bone ultrastructural analyses in children have not been reported and sparse evidence exists on response to bisphosphonate (BP) therapy. Objective: To investigate clinical and bone histomorphometric characteristics, bone matrix mineralization and the response of bone geometry and density to BP therapy. Patients: Five children with HJCYS (3 males) aged between 6...
September 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938077/one-step-for-a-hospital-ten-steps-for-women-african-american-women-s-experiences-in-a-newly-accredited-baby-friendly-hospital
#13
Elizabeth M Miller, Adetola F Louis-Jacques, Tara F Deubel, Ivonne Hernandez
BACKGROUND: Despite strides made by the Baby-Friendly Hospital Initiative to improve and normalize breastfeeding, considerable racial inequality persists in breastfeeding rates. Few studies have explored African American women's experience in a Baby-Friendly Hospital Initiative system to understand sources of this inequality. Research aim: This study aimed to explore African American women's experiences of the Ten Steps to Successful Breastfeeding at a women's center associated with a university-affiliated hospital that recently achieved Baby-Friendly status...
September 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28938075/the-human-plasma-proteome-draft-of-2017-building-on-the-human-plasma-peptideatlas-from-mass-spectrometry-and-complementary-assays
#14
Jochen M Schwenk, Gilbert S Omenn, Zhi Sun, David S Campbell, Mark S Baker, Christopher M Overall, Ruedi Aebersold, Robert L Moritz, Eric W Deutsch
Human blood plasma provides a highly accessible window to the proteome of any individual in health and disease. Since its inception in 2002, the Human Proteome Organization's Human Plasma Proteome Project (HPPP) has been promoting advances in the study and understanding of the full protein complement of human plasma and on determining the abundance and modifications of its components. In 2017, we review the history of the HPPP and the advances of human plasma proteomics in general, including several recent achievements...
September 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28937457/is-a-drain-tip-culture-required-after-spinal-surgery
#15
Kazuyoshi Kobayashi, Shiro Imagama, Zenya Ito, Kei Ando, Hideki Yagi, Tetsuro Hida, Kenyu Ito, Yoshimoto Ishikawa, Mikito Tsushima, Naoki Ishiguro
STUDY DESIGN: The efficacy of use of a drain tip culture for early detection of surgical-site infection (SSI) was investigated in 329 patients after spinal surgery. OBJECTIVE: To examine the efficacy of a wound drain tip culture for detection of SSI in spinal surgery. SUMMARY OF BACKGROUND DATA: A complication of SSI after spinal surgery has high associated morbidity and mortality, and is often difficult to treat. MATERIALS AND METHODS: The subjects were patients who underwent spinal surgery at our institution between January 2010 and March 2013...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28936848/-simultaneous-determination-of-seven-alkaloids-and-three-flavonoids-in-sophorae-tonkinensis-radix-et-rhizoma-by-hplc
#16
Fu-Man Han, Li-Xin Wang, Ying Chen, Liang-Mian Chen, Wei-Hong Feng, Jin-Yu Wang, De-Wen Liu, Yun You, Yan Tong
In this study, an HPLC method was developed for simultaneous determination of seven alkaloids (cytosine, oxymatrine, N-oxysophocarpine, N-methylcytisine, sophoranol, matrine, and sophocarpine) and three flavonoids (trifolirhizin, fermononetin, and maackiain) from different samples of Sophorae Tonkinensis Radix et Rhizoma. Samples were analyzed on a Welch XtimateTM C₁₈ column (4. 6 mm× 250 mm, 5 μm) eluted with the mobile phase of acetonitrile (A) and 0.01 mol•L⁻¹ ammonium acetate solution (pH 8.0) (B) in a linear gradient mode as follows: 0-20 min,4%-14% A;20-30 min,14%-25% A;30-45 min,25%-40% A;45-65 min,40%-55% A;65-75 min,55% A...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936792/alpha-theta-neurofeedback-increases-mentalization-and-default-mode-network-connectivity-in-a-non-clinical-sample
#17
Claudio Imperatori, Giacomo Della Marca, Noemi Amoroso, Giulia Maestoso, Enrico Maria Valenti, Chiara Massullo, Giuseppe Alessio Carbone, Anna Contardi, Benedetto Farina
Several studies showed the effectiveness of alpha/theta (A/T) neurofeedback training in treating some psychiatric conditions. Despite the evidence of A/T effectiveness, the psychological and neurobiological bases of its effects is still unclear. The aim of the present study was to explore the usefulness of the A/T training in increasing mentalization in a non-clinical sample. The modifications of electroencephalographic (EEG) functional connectivity in Default Mode Network (DMN) associated with A/T training were also investigated...
September 21, 2017: Brain Topography
https://www.readbyqxmd.com/read/28935660/childhood-adversities-and-post-traumatic-stress-disorder-evidence-for-stress-sensitisation-in-the-world-mental-health-surveys
#18
Katie A McLaughlin, Karestan C Koenen, Evelyn J Bromet, Elie G Karam, Howard Liu, Maria Petukhova, Ayelet Meron Ruscio, Nancy A Sampson, Dan J Stein, Sergio Aguilar-Gaxiola, Jordi Alonso, Guilherme Borges, Koen Demyttenaere, Rumyana V Dinolova, Finola Ferry, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Norito Kawakami, Sing Lee, Fernando Navarro-Mateu, Marina Piazza, Beth-Ellen Pennell, José Posada-Villa, Margreet Ten Have, Maria Carmen Viana, Ronald C Kessler
BackgroundAlthough childhood adversities are known to predict increased risk of post-traumatic stress disorder (PTSD) after traumatic experiences, it is unclear whether this association varies by childhood adversity or traumatic experience types or by age.AimsTo examine variation in associations of childhood adversities with PTSD according to childhood adversity types, traumatic experience types and life-course stage.MethodEpidemiological data were analysed from the World Mental Health Surveys (n = 27 017)...
September 21, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28933526/impact-of-radioguided-occult-lesion-localization-roll-in-the-management-of-cervical-recurrences-from-differentiated-thyroid-cancer
#19
Viviana Garbaccio, Massimo Menga, Giovanni Mensa, Roberto Passera, Antonello Galati, Alessandra Codegone, Monica Finessi, Emanuela Pilati, Désirée Deandreis, Riccardo E Pellerito
BACKGROUND: Surgery is the elective treatment for cervical relapse from differentiated thyroid cancer (DTC) but it is technically challenging, with risk of failure and morbidity. We explored the feasibility and the efficacy of Radioguided Occult Lesion Localization (ROLL) with intratumoral 99mTc radiolabeled human albumin macroaggregates ([99mTc]MAA) injection in this setting. METHODS: Fifteen patients who underwent ROLL by ultrasonography (US)-guided intratumoral injection of [99mTc]MAA between December 2013 and October 2016 for DTC recurrence were considered for this study...
September 20, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28932983/prevention-and-management-of-vascular-complications-in-middle-ear-and-cochlear-implant-surgery
#20
Filippo Di Lella, Maurizio Falcioni, Silvia Piccinini, Ilaria Iaccarino, Andrea Bacciu, Enrico Pasanisi, Davide Cerasti, Vincenzo Vincenti
The objective of this study is to illustrate prevention strategies and management of vascular complications from the jugular bulb (JB) and internal carotid artery (ICA) during middle ear surgery or cochlear implantation. The study design is retrospective case series. The setting is tertiary referral university hospital. Patients were included if presented pre- or intraoperative evidence of high-risk anatomical anomalies of ICA or JB during middle ear or cochlear implant surgery, intraoperative vascular injury, or revision surgery after the previous iatrogenic vascular lesions...
September 20, 2017: European Archives of Oto-rhino-laryngology
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