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https://www.readbyqxmd.com/read/29792572/galnac-sirna-conjugates-leading-the-way-for-delivery-of-rnai-therapeutics
#1
Aaron D Springer, Steven F Dowdy
Short-interfering RNA (siRNA)-induced RNAi responses have great potential to treat a wide variety of human diseases from cancer to pandemic viral outbreaks to Parkinson's Disease. However, before siRNAs can become drugs, they must overcome a billion years of evolutionary defenses designed to keep invading RNAs on the outside cells from getting to the inside of cells. Not surprisingly, significant effort has been placed in developing a wide array of delivery technologies. Foremost of these has been the development of N-acetylgalactosamine (GalNAc) siRNA conjugates for delivery to liver...
May 24, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29792295/supply-and-demand-in-mhealth-apps-for-persons-with-multiple-sclerosis-systematic-search-in-app-stores-and-scoping-literature-review
#2
REVIEW
Guido Giunti, Estefanía Guisado Fernández, Enrique Dorronzoro Zubiete, Octavio Rivera Romero
BACKGROUND: Multiple sclerosis (MS) is a non-curable chronic inflammatory disease of the central nervous system that affects more than 2 million people worldwide. MS-related symptoms impact negatively on the quality of life of persons with MS, who need to be active in the management of their health. mHealth apps could support these patient groups by offering useful tools, providing reliable information, and monitoring symptoms. A previous study from this group identified needs, barriers, and facilitators for the use of mHealth solutions among persons with MS...
May 23, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29791736/program-to-improve-private-early-education-pipe-a-case-study-of-a-systems-approach-for-scaling-quality-early-education-solutions
#3
Vikram Jain, Ahmed Irfan, Gauri Kirtane Vanikar
FSG is a mission-driven nonprofit organization supporting leaders in creating large-scale, lasting social change. A survey conducted by FSG in 2015 across 4407 low-income families in urban India showed that 95% of them send their children to preschools, a majority of choosing affordable private preschools (APSs), as parents perceive the quality of government schools to be poor. Parents use and value rote-based methods (e.g., reciting poems) to assess their children's learning in school; however, these methods fail to measure conceptual understanding...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29791259/a-pragmatic-trial-of-e-cigarettes-incentives-and-drugs-for-smoking-cessation
#4
Scott D Halpern, Michael O Harhay, Kathryn Saulsgiver, Christine Brophy, Andrea B Troxel, Kevin G Volpp
Background Whether financial incentives, pharmacologic therapies, and electronic cigarettes (e-cigarettes) promote smoking cessation among unselected smokers is unknown. Methods We randomly assigned smokers employed by 54 companies to one of four smoking-cessation interventions or to usual care. Usual care consisted of access to information regarding the benefits of smoking cessation and to a motivational text-messaging service. The four interventions consisted of usual care plus one of the following: free cessation aids (nicotine-replacement therapy or pharmacotherapy, with e-cigarettes if standard therapies failed); free e-cigarettes, without a requirement that standard therapies had been tried; free cessation aids plus $600 in rewards for sustained abstinence; or free cessation aids plus $600 in redeemable funds, deposited in a separate account for each participant, with money removed from the account if cessation milestones were not met...
May 23, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29790779/the-two-by-four-appliance-a-nationwide-cross-sectional-survey
#5
V Quinzi, R Ferro, F A Rizzo, E M Marranzini, F Federici Canova, S Mummolo, A Mattei, G Marzo
AIM: The aim of the study was to investigate how widespread is the use of the 2 x 4 appliance among Italian general dentists and specialists in orthodontics, as well as the type of treatment employed and length of use. MATERIALS AND METHODS: We conducted a nationwide cross-sectional survey from July 14, 2016 to January 12, 2017 using an online questionnaire of 8 multiple choice questions, created by the SurveyMonkey® Company, on a population of Italian dentists and specialists in orthodontics affiliated with the Italian Society of Paediatric Dentistry (SIOI)...
June 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29789878/nuts-as-a-replacement-for-carbohydrates-in-the-diabetic-diet-a-reanalysis-of-a-randomised-controlled-trial
#6
David J A Jenkins, Cyril W C Kendall, Benoît Lamarche, Monica S Banach, Korbua Srichaikul, Edward Vidgen, Sandy Mitchell, Tina Parker, Stephanie Nishi, Balachandran Bashyam, Russell J de Souza, Christopher Ireland, Sathish C Pichika, Joseph Beyene, John L Sievenpiper, Robert G Josse
AIMS/HYPOTHESIS: In line with current advice, we assessed the effect of replacing carbohydrate consumption with mixed nut consumption, as a source of unsaturated fat, on cardiovascular risk factors and HbA1c in type 2 diabetes. The data presented here are from a paper that was retracted at the authors' request ( https://doi.org/10.2337/dc16-rt02 ) owing to lack of adjustment for repeated measures in the same individual. Our aim, therefore, was to fix the error and add new complementary data of interest, including information on clotting factors and LDL particle size...
May 23, 2018: Diabetologia
https://www.readbyqxmd.com/read/29789311/fda-tackles-underage-e-cigarette-use
#7
(no author information available yet)
In recent weeks, the FDA has taken steps to address underage use of e-cigarettes: The agency has identified and warned retailers selling to minors, issued warning letters to companies selling e-cigarette cartridges in adolescent-appealing packaging, and requested information from e-cigarette companies. The steps are part of the FDA's ongoing effort to prevent middle- and high-school students from using e-cigarette products.
May 22, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29789283/safety-of-medicines-delivered-by-homecare-companies
#8
EDITORIAL
Anthony Matthews, Liam J Donaldson, Stephen J Evans, Sinéad M Langan
No abstract text is available yet for this article.
May 22, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29789079/chimia-report-company-news
#9
(no author information available yet)
No abstract text is available yet for this article.
May 30, 2018: Chimia
https://www.readbyqxmd.com/read/29788221/predictive-factors-of-life-quality-among-packaging-workers-in-taiwan
#10
Shang-Yu Yang, Der-Jen Hsu, Chun-Ming Yen, Jer-Hao Chang
The semiconductor plants on the top of high-tech industrial chain hire many packaging workers to carry out miscellaneous packing tasks for various product orders from different companies and countries. Under tremendous workload the quality of life (QoL) of such packaging workers need to be concerned. The aim of this study was to explore factors influencing their QoL. This study recruited 247 packing workers (162 male and 85 female; mean age: 35.6 years old) in 2015 and 2016 from a semiconductor plant in Taiwan by convenience sampling...
May 16, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29786828/oral-contraceptives-for-pain-associated-with-endometriosis
#11
REVIEW
Julie Brown, Tineke J Crawford, Shree Datta, Andrew Prentice
BACKGROUND: Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The combined oral contraceptive pill (COCP) is widely used to treat pain occurring as a result of endometriosis, although the evidence for its efficacy is limited. OBJECTIVES: To determine the effectiveness, safety and cost-effectiveness of oral contraceptive preparations in the treatment of painful symptoms ascribed to the diagnosis of laparoscopically proven endometriosis...
May 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29786684/-the-development-of-the-system-of-medical-rehabilitation-based-at-the-russian-health-resort-facilities-investment-prospects
#12
E L Povazhnaya, E V Gusakova, S V Moiseenko
The present work is devoted to the prospects for attracting investments for the maintenance and development of the medical rehabilitation practices based at the Russian health resort facilities. The article describes the prerequisites for the enhancement of the investment attractiveness of the development of the system of medical rehabilitation in the said institutions including the formulation and strengthening of the legal and regulatory framework, the capacity for the organization of the second and third stages of medical rehabilitation in the existing spa and health resort facilities, the attraction of the funds of compulsory medical insurance as an additional source of the financial support...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29785789/american-college-of-cardiology-2018
#13
Ann M Carracher, Payal H Marathe, Kelly L Close
Ann M. Carracher, Payal H. Marathe, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Carracher, Marathe, and Close review the latest developments relevant to researchers and clinicians.
May 21, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29784836/margaret-mccartney-tech-companies-healthcare-and-a-clash-of-cultures
#14
Margaret McCartney
No abstract text is available yet for this article.
May 21, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29783790/quality-traits-of-cannabidiol-oils-cannabinoids-content-terpene-fingerprint-and-oxidation-stability-of-european-commercially-available-preparations
#15
Radmila Pavlovic, Giorgio Nenna, Lorenzo Calvi, Sara Panseri, Gigliola Borgonovo, Luca Giupponi, Giuseppe Cannazza, Annamaria Giorgi
Cannabidiol (CBD)-based oil preparations are becoming extremely popular, as CBD has been shown to have beneficial effects on human health. CBD-based oil preparations are not unambiguously regulated under the European legislation, as CBD is not considered as a controlled substance. This means that companies can produce and distribute CBD products derived from non-psychoactive hemp varieties, providing an easy access to this extremely advantageous cannabinoid. This leaves consumers with no legal quality guarantees...
May 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29783752/pro-apoptotic-and-anti-cancer-properties-of-diosgenin-a-comprehensive-and-critical-review
#16
REVIEW
Gautam Sethi, Muthu K Shanmugam, Sudha Warrier, Myriam Merarchi, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee
Novel and alternative options are being adopted to combat the initiation and progression of human cancers. One of the approaches is the use of molecules isolated from traditional medicinal herbs, edible dietary plants and seeds that play a pivotal role in the prevention/treatment of cancer, either alone or in combination with existing chemotherapeutic agents. Compounds that modulate these oncogenic processes are potential candidates for cancer therapy and may eventually make it to clinical applications. Diosgenin is a naturally occurring steroidal sapogenin and is one of the major bioactive compounds found in dietary fenugreek ( Trigonella foenum-graecum ) seeds...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29780033/public-attitudes-in-england-towards-the-sharing-of-personal-data-following-a-mass-casualty-incident-a-cross-sectional-study
#17
G James Rubin, Rebecca Webster, Antonia N Rubin, Richard Amlot, Nick Grey, Neil Greenberg
OBJECTIVES: To assess public attitudes towards data sharing to facilitate a mental health screening programme for people caught up in a mass casualty incident. DESIGN: Two, identical, cross-sectional, online surveys, using quotas to ensure demographic representativeness of people aged 18-65 years in England. Participants were randomly allocated to consider a scenario in which they witness a terrorism-related radiation incident or mass shooting, after which a police officer records their contact details...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779966/developing-and-deploying-climate-resilient-maize-varieties-in-the-developing-world
#18
REVIEW
Jill E Cairns, B M Prasanna
In sub-Saharan Africa (SSA) and Asia maize yields remain variable due to climate shocks. Over the past decade extensive progress has been made on the development and delivery of climate-resilient maize. In 2016 over 70000 metric tonnes of drought-tolerant maize seed was commercialized in 13 countries in SSA, benefiting an estimated 53 million people. Significant progress is also being made with regard to the development and deployment of elite heat-tolerant maize varieties in South Asia. Increased genetic gain in grain yield under stress-prone environments, coupled with faster replacement of old/obsolete varieties, through intensive engagement with seed companies is essential to protect maize crops grown by smallholders from the changing climates in SSA and Asia...
May 17, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29778952/-too-much-of-a-good-thing-the-role-of-advanced-eco-learning-and-contingency-factors-on-the-relationship-between-corporate-environmental-and-financial-performance
#19
Hengky Latan, Charbel Jose Chiappetta Jabbour, Ana Beatriz Lopes de Sousa Jabbour, Douglas William Scott Renwick, Samuel Fosso Wamba, Muhammad Shahbaz
Inspired by the natural-resource-based view (NRBV) theory, we attempt to shed light on a controversy which has been persistent over the last decade, concerning the relationship between corporate environmental performance (CEP) and corporate financial performance (CFP). Using the 'too-much-of-a-good-thing' (TMGT) concept, which suggests that "too much can be worse than too little," we link mixed results and consider the roles of advanced eco-learning and contingency factors in influencing the CEP-CFP relationship...
May 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29778667/cardiovascular-risk-factors-is-the-metabolic-syndrome-related-to-aging-epidemiology-in-a-portuguese-population
#20
Armindo Sousa Ribeiro, Rui Seixas, Juan Manuel Gálvez, Vicente Climent
AIMS: The primary objective of our study is to determine the prevalence of the metabolic syndrome in the population. The secondary objective is to determine the prevalence of cardiovascular risk factors, anthropometric alterations and the prevalence of target organ damage and their relationship with aging. MATERIAL AND METHODS: The sample for the study was obtained by means of a consecutive population-based demonstration in 803 adults over 18 years of age belonging to the labor force of the company Grupo Delta SA...
May 16, 2018: Diabetes & Metabolic Syndrome
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