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https://www.readbyqxmd.com/read/29331888/a-longitudinal-analysis-of-ido-and-pdl1-expression-during-immune-or-targeted-therapy-in-advanced-melanoma
#1
Lukas Krähenbühl, Simone M Goldinger, Joanna Mangana, Katrin Kerl, Ines Chevolet, Liève Brochez, Christine Horak, Mitch Levesque, Reinhard Dummer, Phil F Cheng
A deepened understanding of the cellular and molecular processes in the tumor microenvironment is necessary for the development of precision immunotherapy (IT). We simultaneously investigated CD3, PDL1, and IDO by immunohistochemistry in paired biopsies from various organs of 43 metastatic melanoma patients treated with IT and targeted therapy (TT). Intraindividual biopsies taken after a period of weeks to months demonstrate discordant results in 30% of the cases. Overlap of IDO and PDL1 increased after therapy...
January 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29331843/performance-of-genotypic-algorithms-for-predicting-tropism-for-hiv-1-crf01_ae-recombinant
#2
C Soulie, L Morand-Joubert, J Cottalorda, C Charpentier, P Bellecave, L Le Guen, S Yerly, B Montes, S Fafi-Kremer, J Dina, V Avettand-Fenoel, C Amiel, C Roussel, C Pallier, K Zafilaza, S Sayon, A Signori-Schmuck, A Mirand, M A Trabaud, S Berger, V Calvez, A G Marcelin
OBJECTIVES: There is no consensus about the performances of genotypic rules for predicting HIV-1 non-B subtype tropism. Three genotypic methods were compared for CRF01_AE HIV-1 tropism determination. METHODS: The V3 env region of 207 HIV-1 CRF01_AE and 178 B subtypes from 17 centers in France and 1 center in Switzerland was sequenced. Tropism was determined by Geno2Pheno algorithm with false positive rate (FPR) 5% or 10%, the 11/25 rule or the combined criteria of the 11/25, net charge rule and NXT/S mutations...
January 8, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29331746/canadian-neurosurgery-educators-views-on-stereotactic-radiosurgery-in-residency-training
#3
Nardin Samuel, Justine Philteos, Naif M Alotaibi, Christopher Ahuja, Alireza Mansouri, Abhaya V Kulkarni
OBJECTIVE: Despite the increasing prominence of stereotactic radiosurgery (SRS) in treating intracranial and spinal pathologies, there is currently a dearth of exposure to this modality in neurosurgical residency. To address this gap, the aim of this study is to assess neurosurgery educators' views regarding the current state of SRS exposure, and to identify potential approaches to improve residency education in this domain. METHODS: Qualitative thematic analysis and constructivist grounded theory methodology were employed...
January 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29331083/variation-in-reproductive-outcomes-of-women-with-histories-of-bulimia-nervosa-anorexia-nervosa-or-eating-disorder-not-otherwise-specified-relative-to-the-general-population-and-closest-aged-sisters
#4
Jennifer Tabler, Rebecca L Utz, Ken R Smith, Heidi A Hanson, Claudia Geist
OBJECTIVE: This study seeks to examine the long-term reproductive consequences of eating disorders (ED), to assess variation in reproductive outcomes by ED type, and to examine reproductive differences between women with previous ED diagnosis and their discordant sisters. METHOD: Using a sample of women with previous ED diagnosis generated by the Utah Population Database, this study compares the fecundity (parity) and age at first birth of women by ED subtype (bulimia nervosa [BN], anorexia nervosa [AN], and ED not otherwise specified [EDNOS]) (n = 1,579)...
January 13, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29330774/a-collection-of-xy-female-cell-lines
#5
Fumio Kasai, Malcolm A Ferguson-Smith
Discordance between sexual phenotype and the 46,XY sex chromosome complement may be found in certain disorders of sexual development (DSD). Many of these DSD patients with female external genitalia and secondary sex characteristics have undescended testes and male internal genitalia. Causative mutations involving genes of the sex determining pathway, including the androgen receptor, SRY and the 5-alpha-reductase genes, are well-known, but the origin of other cases remain unresolved. In this report, we introduce our collection of lymphoblastoid lines derived from female patients with a 46,XY karyotype...
January 12, 2018: Human Cell
https://www.readbyqxmd.com/read/29330751/prospective-trial-evaluating-the-sensitivity-and-specificity-of-3-4-dihydroxy-6-18f-fluoro-l-phenylalanine-18f-dopa-pet-and-mri-in-patients-with-recurrent-gliomas
#6
Ryan S Youland, Deanna H Pafundi, Debra H Brinkmann, Val J Lowe, Jonathan M Morris, Bradley J Kemp, Christopher H Hunt, Caterina Giannini, Ian F Parney, Nadia N Laack
Treatment-related changes can be difficult to differentiate from progressive glioma using MRI with contrast (CE). The purpose of this study is to compare the sensitivity and specificity of 18F-DOPA-PET and MRI in patients with recurrent glioma. Thirteen patients with MRI findings suspicious for recurrent glioma were prospectively enrolled and underwent 18F-DOPA-PET and MRI for neurosurgical planning. Stereotactic biopsies were obtained from regions of concordant and discordant PET and MRI CE, all within regions of T2/FLAIR signal hyperintensity...
January 13, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29330391/impact-of-antithymocyte-globulin-doses-in-reduced-intensity-conditioning-before-allogeneic-transplantation-from-matched-sibling-donor-for-patients-with-acute-myeloid-leukemia-a-report-from-the-acute-leukemia-working-party-of-european-group-of-bone-marrow-transplantation
#7
Raynier Devillier, Myriam Labopin, Patrice Chevallier, Marie-Pierre Ledoux, Gérard Socié, Anne Huynh, Jean-Henri Bourhis, Jean-Yves Cahn, Gabrielle Roth-Guepin, Ghulam Mufti, Déborah Desmier, Mauricette Michallet, Nathalie Fegueux, Fabio Ciceri, Fréderic Baron, Didier Blaise, Arnon Nagler, Mohamad Mohty
Antithymocyte globulin (ATG) is commonly used for graft-vs.-host disease (GVHD) prophylaxis in unrelated donor allogeneic transplantation (Allo-HSCT). However, its use is still controversial in matched sibling donor (MSD) Allo-HSCT, notably after reduced intensity conditioning (RIC). ATG dose may influence the outcome, explaining in part the discordant conclusions in MSD Allo-HSCT. We, therefore, analyzed the impact of ATG doses in patients with acute myeloid leukemia in first complete remission undergoing RIC Allo-HSCT from a MSD...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29327393/pulmonary-hypertension-in-interstitial-lung-disease-limitations-of-echocardiography-compared-to-cardiac-catheterization
#8
Gregory J Keir, S John Wort, Maria Kokosi, Peter M George, Simon L F Walsh, Joseph Jacob, Laura Price, Simon Bax, Elisabetta A Renzoni, Toby M Maher, Peter MacDonald, David M Hansell, Athol U Wells
BACKGROUND AND OBJECTIVE: In interstitial lung disease (ILD), pulmonary hypertension (PH) is a major adverse prognostic determinant. Transthoracic echocardiography (TTE) is the most widely used tool when screening for PH, although discordance between TTE and right heart catheter (RHC) measured pulmonary haemodynamics is increasingly recognized. We evaluated the predictive utility of the updated European Society of Cardiology/European Respiratory Society (ESC/ERS) TTE screening recommendations against RHC testing in a large, well-characterized ILD cohort...
January 12, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29325822/parental-vaccine-hesitancy-in-italy-results-from-a-national-survey
#9
Cristina Giambi, Massimo Fabiani, Fortunato D'Ancona, Lorenza Ferrara, Daniel Fiacchini, Tolinda Gallo, Domenico Martinelli, Maria Grazia Pascucci, Rosa Prato, Antonietta Filia, Antonino Bella, Martina Del Manso, Caterina Rizzo, Maria Cristina Rota
In Italy, in 2016, we conducted a cross-sectional survey to estimate vaccine hesitancy and investigate its determinants among parents of children aged 16-36 months. Data on parental attitudes and beliefs about vaccinations were collected through a questionnaire administered online or self-administered at pediatricians' offices and nurseries. Parents were classified as pro-vaccine, vaccine-hesitant or anti-vaccine, according to self-reported tetanus and measles vaccination status of their child. Multivariable logistic regression was used to investigate factors associated with hesitancy...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29325428/mother-child-coregulation-of-parasympathetic-processes-differs-by-child-maltreatment-severity-and-subtype
#10
Erika Lunkenheimer, Alex Busuito, Kayla M Brown, Elizabeth A Skowron
Parasympathetic processes appear to underlie maladaptive parent-child interactions in maltreating families, but it is unknown whether parent-child coregulation of respiratory sinus arrhythmia (RSA) differs by child maltreatment severity and subtype. RSA coregulation in maltreating and nonmaltreating mother-child dyads ( N = 146; age 3-5 years) during two dyadic tasks was analyzed using dynamic time series modeling. Nonmaltreating dyads showed positive RSA concordance but maltreating dyads (when examined as one group) did not...
January 1, 2018: Child Maltreatment
https://www.readbyqxmd.com/read/29324459/discordance-between-lipoprotein-particle-number-and-cholesterol-content-an-update
#11
Eric P Cantey, John T Wilkins
PURPOSE OF REVIEW: The cholesterol content within atherogenic apolipoprotein-B (apoB) containing lipid particles is the center of consensus guidelines and clinicians' focus whenever evaluating a patient's risk for atherosclerotic cardiovascular disease. The pathobiology of atherosclerosis requires the retention of lipoprotein particles within the vascular intima over time followed by maladaptive inflammation resulting in plaque formation and rupture in some. The cholesterol content is widely variable within each particle creating either cholesterol-deplete or cholesterol-enriched particles...
January 10, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29322517/discordant-human-t-lymphotropic-virus-screening-with-western-blot-confirmation-evaluation-of-the-dual-test-algorithm-for-us-blood-donations
#12
Susan L Stramer, Rebecca L Townsend, Gregory A Foster, Ramona Johnson, Barbara Weixlmann, Roger Y Dodd
BACKGROUND: Human T-lymphotropic virus (HTLV) blood donation screening has used a dual-testing algorithm beginning with either a chemiluminescent immunoassay or enzyme-linked immunosorbent screening assay (ELISA). Before the availability of a licensed HTLV supplemental assay, repeat-reactive (RR) samples on a first assay (Assay 1) were retested with a second screening assay (Assay 2). Donors with RR results by Assay 2 were deferred from blood donation and further tested using an unlicensed supplemental test to confirm reactivity while nonreactive (NR) donors remained eligible for donation until RR on a subsequent donation...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29321908/rapid-song-divergence-leads-to-discordance-between-genetic-distance-and-phenotypic-characters-important-in-reproductive-isolation
#13
Emmanuel C Nwankwo, Chryso Th Pallari, Louis Hadjioannou, Andreas Ioannou, Ronald K Mulwa, Alexander N G Kirschel
The criteria for species delimitation in birds have long been debated, and several recent studies have proposed new methods for such delimitation. On one side, there is a large consensus of investigators who believe that the only evidence that can be used to delimit species is molecular phylogenetics, and with increasing numbers of markers to gain better support, whereas on the other, there are investigators adopting alternative approaches based largely on phenotypic differences, including in morphology and communication signals...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321849/population-genomics-and-geographical-parthenogenesis-in-japanese-harvestmen-opiliones-sclerosomatidae-leiobunum
#14
Mercedes Burns, Marshal Hedin, Nobuo Tsurusaki
Naturally occurring population variation in reproductive mode presents an opportunity for researchers to test hypotheses regarding the evolution of sex. Asexual reproduction frequently assumes a geographical pattern, in which parthenogenesis-dominated populations are more broadly dispersed than their sexual conspecifics. We evaluate the geographical distribution of genomic signatures associated with parthenogenesis using nuclear and mitochondrial DNA sequence data from two Japanese harvestman sister taxa, Leiobunum manubriatum and Leiobunum globosum...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321128/measurement-of-lipoprotein-associated-phospholipase-a2-by-use-of-3-different-methods-exploration-of-discordance-between-elisa-and-activity-assays
#15
Celalettin Topbas, Alan Swick, Morteza Razavi, N Leigh Anderson, Terry W Pearson, Cory Bystrom
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme associated with inflammation, is used as a biomarker for cardiovascular disease risk. Both the concentration and activity of Lp-PLA2 have been shown to be clinically relevant. However, there is a discordance between the serum concentration of Lp-PLA2 measured by the standard ELISA-based immunoassays and the activity of this enzyme, leading to substantial discordance in risk categorization depending on assay format...
January 10, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29319814/single-versus-multiple-sample-method-to-measure-glomerular-filtration-rate
#16
Pierre Delanaye, Martin Flamant, Laurence Dubourg, Emmanuelle Vidal-Petiot, Sandrine Lemoine, Etienne Cavalier, Elke Schaeffner, Natalie Ebert, Hans Pottel
Background: There are many different ways to measure glomerular filtration rate (GFR) using various exogenous filtration markers, each having their own strengths and limitations. However, not only the marker, but also the methodology may vary in many ways, including the use of urinary or plasma clearance, and, in the case of plasma clearance, the number of time points used to calculate the area under the concentration-time curve, ranging from only one (Jacobsson method) to eight (or more) blood samples...
January 8, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29319629/patterns-of-discordance-between-pretransplant-imaging-stage-of-hepatocellular-carcinoma-and-posttransplant-pathologic-stage-a-contemporary-appraisal-of-the-milan-criteria
#17
Brett L Ecker, Maarouf A Hoteit, Kimberly A Forde, Christine C Hsu, K Rajender Reddy, Emma E Furth, Evan S Siegelman, Peiman Habibollahi, Edgar Ben-Josef, Paige M Porrett, Peter L Abt, Abraham Shaked, Kim M Olthoff, Matthew H Levine
BACKGROUND: Patients with hepatocellular carcinoma (HCC) exceeding Milan criteria on explant pathology are at increased risk of recurrence and death. Discordance between contemporary magnetic resonance imaging (MRI) and explant pathology, and preoperative characteristics predictive of discordance are not well understood. METHODS: Patients who underwent orthotopic liver transplantation (OLT) for HCC following preoperative MRI were identified in a prospectively collected institutional database (1/2003-12/2013)...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29318636/a-multicentred-study-to-validate-a-consensus-bleeding-assessment-tool-developed-by-the-biomedical-excellence-for-safer-transfusion-collaborative-for-use-in-patients-with-haematological-malignancy
#18
C Dyer, C R Alquist, M Cole-Sinclair, E Curnow, N M Dunbar, L J Estcourt, R Kaufman, J M Kutner, J McCullough, Z McQuilten, L Potiphar, B Rioux-Masse, S Slichter, A Tinmouth, K Webert, A P Yokoyama, S J Stanworth
BACKGROUND: There continues to be uncertainty about the optimal approach to documenting bleeding data in platelet transfusion trials, with a desire to apply a common assessment tool across all trials. With this in mind, a consensus bleeding assessment tool (BAT) has been developed by the Biomedical Excellence for Safer Transfusion (BEST) collaborative, based on review of data collection forms used in published randomized trials and following content validation with a range of healthcare professionals at seven haematology centres through BEST members...
January 10, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29318005/precision-medicine-does-ethnicity-information-complement-genotype-based-prescribing-decisions
#19
REVIEW
Rashmi R Shah, Andrea Gaedigk
Inter-ethnic differences in drug response are all too well known. These are underpinned by a number of factors, including pharmacogenetic differences across various ethnic populations. Precision medicine relies on genotype-based prescribing decisions with the aim of maximizing efficacy and mitigating the risks. When there is no access to genotyping tests, ethnicity is frequently regarded as a proxy of the patient's probable genotype on the basis of overall population-based frequency of genetic variations in the ethnic group the patient belongs to, with some variations being ethnicity-specific...
January 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29316887/how-do-informal-information-sources-influence-women-s-decision-making-for-birth-a-meta-synthesis-of-qualitative-studies
#20
Ruth A Sanders, Kenda Crozier
BACKGROUND: Women approach birth using various methods of preparation drawing from conventional healthcare providers alongside informal information sources (IIS) outside the professional healthcare context. An investigation of the forms in which these informal information sources are accessed and negotiated by women, and how these disconnected and often conflicting elements influence women's decision-making process for birth have yet to be evaluated. The level of antenatal preparedness women feel can have significant and long lasting implications on their birth experience and transition into motherhood and beyond...
January 10, 2018: BMC Pregnancy and Childbirth
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