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https://www.readbyqxmd.com/read/28743029/thermoresponsive-nanoparticle-agglomeration-aggregation-in-salt-solutions-dependence-on-graft-density
#1
Thaddeus W Vasicek, Samir V Jenkins, Leticia Vaz, Jingyi Chen, Julie A Stenken
Gold nanoparticles with a graft density of 0.09, 0.30 and 0.40chains/nm(2) of poly(N-isopropylacrylamide) were reproducibly synthesized by varying the ratio of disulfide terminated poly(N-isopropylacrylamide) to gold nanoparticle. The polymer coated nanoparticles were stable at room temperature in 50mM NaCl, yet agglomerated at 37°C. Previous studies have observed conflicting results as to the reversibility of this agglomeration. Particle agglomeration with three different graft densities was studied in 50mM NaCl by measurements of their localized surface plasmon resonance and hydrodynamic diameter, and imaging with electron microscopy...
July 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28742827/the-relationship-between-coronary-artery-distensibility-and-fractional-flow-reserve
#2
Andy S C Yong, Ashkan Javadzadegan, William F Fearon, Abouzar Moshfegh, Jerrett K Lau, Stephen Nicholls, Martin K C Ng, Leonard Kritharides
Discordance between angiography-based anatomical assessment of coronary stenosis severity and fractional flow reserve (FFR) has been attributed to several factors including lesion length and irregularity, and the myocardial territory supplied by the target vessel. We sought to examine if coronary arterial distensibility is an independent contributor to this discordance. There were two parts to this study. The first consisted of "in silico" models of 26 human coronary arteries. Computational fluid dynamics-derived FFR was calculated for fully rigid, partially distensible and fully distensible models of the 26 arteries...
2017: PloS One
https://www.readbyqxmd.com/read/28741808/reconciling-disparate-data-to-determine-the-right-answer-a-grounded-theory-of-meta-analysts-reasoning-in-meta-analysis
#3
Lisa Chan, Mary Ellen Macdonald, Franco A Carnevale, Russ Steele, Ian Shrier
While the systematic review process is intended to maximize objectivity and limit researchers' biases, examples remain of discordant recommendations from meta-analyses. Current guidelines to explore discrepancies assume the variation is produced by methodological differences, and thus focus only on the study process. Since heterogeneity of interpretation also occurs when experts examine the same data, our purpose was to examine if there are 'reasoning' differences, i.e., in how information is processed and valued...
July 25, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28741036/network-based-subcellular-proteomics-in-monocyte-membrane-revealed-novel-candidate-genes-involved-in-osteoporosis
#4
Y Zeng, L Zhang, W Zhu, H He, H Sheng, Q Tian, F-Y Deng, L-S Zhang, H-G Hu, H-W Deng
In this study, label-free-based quantitative subcellular proteomics integrated with network analysis highlighted several candidate genes including P4HB, ITGB1, CD36, and ACTN1 that may be involved in osteoporosis. All of them are predicted as significant membrane proteins with high confidence and enriched in bone-related biological process. The results were further verified in transcriptomic and genomic levels. INTRODUCTION: Osteoporosis is a metabolic bone disease mainly characterized by low bone mineral density (BMD)...
July 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28740667/discordance-of-physician-clinical-judgment-vs-pneumonia-severity-index-psi-score-to-admit-patients-with-low-risk-community-acquired-pneumonia-a-prospective-multicenter-study
#5
Pedro J Marcos, Marcos I Restrepo, Francisco J González-Barcala, Nilam J Soni, Iria Vidal, Pilar Sanjuàn, Diego Llinares, Lucía Ferreira-Gonzalez, Carlos Rábade, Isabel Otero-González, Pedro Marcos, Héctor Verea-Hernando
BACKGROUND: The relationship between clinical judgment and the pneumonia severity index (PSI) score in deciding the site of care for patients with community-acquired pneumonia (CAP) has not been well investigated. The objective of the study was to determine the clinical factors that influence decision-making to hospitalize low-risk patients (PSI ≤2) with CAP. METHODS: An observational, prospective, multicenter study of consecutive CAP patients was performed at five hospitals in Spain...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28739710/discrepancy-in-programmed-cell-death-ligand-1-between-primary-and-metastatic-non-small-cell-lung-cancer
#6
Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Nobutaka Mukae, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara
AIM: To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Twenty-one NSCLC patients who underwent surgery or biopsy for paired primary and metastatic lesions at our Institution from 2005 to 2016 were analyzed. Lesions with the PD-L1 expression being ≥5% were considered PD-L1-positive...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739600/whole-genome-sequencing-and-concordance-between-antimicrobial-susceptibility-genotypes-and-phenotypes-of-bacterial-isolates-associated-with-bovine-respiratory-disease
#7
Joseph R Owen, Noelle Noyes, Amy E Young, Daniel J Prince, Patricia C Blanchard, Terry W Lehenbauer, Sharif S Aly, Jessica H Davis, Sean M O'Rourke, Zaid Abdo, Keith Belk, Michael R Miller, Paul Morley, Alison Van Eenennaam
Extended laboratory culture and antimicrobial susceptibility testing timelines hinder rapid species identification and susceptibility profiling of bacterial pathogens associated with bovine respiratory disease, the most prevalent cause of cattle mortality in the United States. Whole genome sequencing offers a culture-independent alternative to current bacterial identification methods but requires a library of bacterial reference genomes for comparison. To contribute new bacterial genome assemblies and evaluate genetic diversity and variation in antimicrobial resistance genotypes, whole-genome sequencing was performed on bovine respiratory disease associated bacterial isolates (Histophilus somni, Mycoplasma bovis, Mannheimia haemolytica, and Pasteurella multocida) from dairy and beef cattle...
July 24, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28739373/analyte-variations-in-consecutive-24-hour-urine-collections-in-children
#8
Jonathan S Ellison, John M Hollingsworth, Craig B Langman, John R Asplin, Andrew L Schwaderer, Phyllis Yan, Maggie Bierlein, Mark A Barraza, William R Defoor, T Ernesto Figueroa, Elizabeth C Jackson, Venkata R Jayanthi, Emilie K Johnson, David B Joseph, Margarett Shnorhavorian
PURPOSE: The metabolic evaluation of children with nephrolithiasis begins with a 24-h urine collection. For adults, the diagnostic yield increases with consecutive collections; however, little is known regarding the variability of multiple 24-h studies in the pediatric population. We sought to evaluate the variability of consecutive 24-h urine collection in children through a multi-institutional study hypothesizing that compared with a single collection, consecutive 24-h urine collections would reveal a greater degree of clinically useful information in the evaluation of children at risk for nephrolithiasis...
July 12, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28739313/cardiac-amyloidosis-an-update-on-pathophysiology-diagnosis-and-treatment
#9
REVIEW
Omar K Siddiqi, Frederick L Ruberg
The amyloidoses are a group of systemic diseases characterized by organ deposition of misfolded protein fragments of diverse origins. The natural history of the disease, involvement of other organs, and treatment options vary significantly based on the protein of origin. In AL amyloidosis, amyloid protein is derived from immunoglobulin light chains, and most often involves the kidneys and the heart. ATTR amyloidosis is categorized as mutant or wild-type depending on the genetic sequence of the transthyretin (TTR) protein produced by the liver...
July 13, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28739270/discrepancies-between-the-use-of-mdrd-4-idms-and-ckd-epi-equations-instead-of-the-cockcroft-gault-equation-in-the-determination-of-the-dosage-of-direct-oral-anticoagulants-in-patients-with-non-valvular-atrial-fibrillation
#10
Alejandro Isidoro Pérez Cabeza, Pedro Antonio Chinchurreta Capote, Jose Antonio González Correa, Francisco Ruiz Mateas, Gabriel Rosas Cervantes, Francisco Rivas Ruiz, Almudena Valle Alberca, Rafael Bravo Marqués
BACKGROUND AND OBJECTIVE: Direct oral anticoagulants (DOACs) require dose adjustment according to estimated clearance creatinine (eClCr) using the Cockcroft-Gault (CG) equation. There are discrepancies with the equations that estimate glomerular filtration rate (eGFR). We analyse how the use of the CKD-EPI and MDRD-4 IDMS equations affect the recommended dosage for ACODs. PATIENTS AND METHODS: Retrospective study of patients with non-valvular atrial fibrillation seen at a cardiology clinic between November 2012 and August 2014...
July 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28738868/comparative-evaluation-of-fluorescent-in-situ-hybridization-and-giemsa-microscopy-with-quantitative-real-time-pcr-technique-in-detecting-malaria-parasites-in-a-holoendemic-region-of-kenya
#11
Joseph Osoga, John Waitumbi, Bernard Guyah, James Sande, Cornel Arima, Michael Ayaya, Caroline Moseti, Collins Morang'a, Martin Wahome, Rachel Achilla, George Awinda, Nancy Nyakoe, Elizabeth Wanja
BACKGROUND: Early and accurate diagnosis of malaria is important in treatment as well as in the clinical evaluation of drugs and vaccines. Evaluation of Giemsa-stained smears remains the gold standard for malaria diagnosis, although diagnostic errors and potential bias estimates of protective efficacy have been reported in practice. Plasmodium genus fluorescent in situ hybridization (P-Genus FISH) is a microscopy-based method that uses fluorescent labelled oligonucleotide probes targeted to pathogen specific ribosomal RNA fragments to detect malaria parasites in whole blood...
July 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28737269/concordance-between-self-reported-and-observer-rated-anxiety-severity-in-outpatients-with-anxiety-disorders-the-leiden-routine-outcome-monitoring-study
#12
Anke Schat, Martijn S van Noorden, Erik J Giltay, Marc J Noom, Robert R J M Vermeiren, Frans G Zitman
OBJECTIVES: Anxiety severity measures can be self-report or observer-rated. Although mostly these measures concur, they can diverge markedly. We examined concordance between two anxiety scales: the observer-rated Brief Anxiety Scale (BAS) and the self-report Brief Symptom Inventory 12-item version (BSI-12), and described associations between patient characteristics and discordance. DESIGN: The study used an observational design, using prospective data from 2,007 outpatients with DSM-IV-TR panic disorder with or without agoraphobia, agoraphobia without panic, social phobia, and/or generalized anxiety disorder...
July 24, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28737043/health-care-providers-and-managers-seeking-concordance-in-the-discord
#13
William B Bateman, Hunter L McQuistion
No abstract text is available yet for this article.
July 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28736395/understanding-the-relationship-between-couple-dynamics-and-engagement-with-hiv-care-services-insights-from-a-qualitative-study-in-eastern-and-southern-africa
#14
Joyce Wamoyi, Jenny Renju, Mosa Moshabela, Estelle McLean, Daniel Nyato, Doris Mbata, Oliver Bonnington, Janet Seeley, Kathryn Church, Basia Zaba, Alison Wringe
OBJECTIVE: To explore the interplay between couple dynamics and the engagement of people living with HIV (PLHIV) with HIV care and treatment services in three health and demographic surveillance sites in Tanzania, Malawi and South Africa. METHODS: A qualitative study was conducted involving 107 in-depth interviews with PLHIV with a range of HIV care and treatment histories, including current users of HIV clinics, and people not enrolled in HIV care. Interviews explored experiences of living with HIV and how and why they chose to engage or not with HIV services...
July 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28736318/psma-targeted-18-f-dcfpyl-pet-ct-in-the-preoperative-staging-of-men-with-high-risk-prostate-cancer-results-of-a-prospective-phase-ii-single-center-study
#15
Michael A Gorin, Steven P Rowe, Hiten D Patel, Igor Vidal, Margarita Mana-Ay, Mehrbod S Javadi, Lilja B Solnes, Ashley E Ross, Edward M Schaeffer, Trinity J Bivalacqua, Alan W Partin, Kenneth J Pienta, Zsolt Szabo, Angelo M De Marzo, Martin G Pomper, Mohamad E Allaf
PURPOSE: To prospectively evaluate the diagnostic performance of PSMA-targeted (18)F-DCFPyL PET/CT in the preoperative staging of men at high risk of harboring metastatic prostate cancer despite a negative conventional staging evaluation. MATERIALS AND METHODS: Men with clinically localized high or very-high risk prostate cancer were imaged with (18)F-DCFPyL PET/CT prior to undergoing radical prostatectomy with a standardized pelvic lymph node dissection. PET/CT scans were interpreted by two blinded nuclear medicine readers and were assessed for inter-reader variability as well as diagnostic accuracy for pelvic lymph node staging...
July 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28735423/the-anticoagulant-effect-of-heparin-during-radiofrequency-ablation-rfa-in-patients-taking-apixaban-or-rivaroxaban
#16
L C Brendel, F Dobler, G Hessling, J Michel, S L Braun, A L Steinsiek, P Groha, R Eckl, I Deisenhofer, A Hyseni, M Roest, I Ott, B Steppich
PURPOSE: Measuring the anticoagulant effect of heparin during radiofrequency ablation (RFA) in patients taking apixaban and rivaroxaban is challenging, since the activated coagulation time (ACT) does not seem to reflect the true anticoagulant activity of these drugs. We therefore evaluated coagulation properties of apixaban and rivaroxaban during RFA by different coagulation assays to better monitor periprocedural hemostasis. METHODS: The study included 90 patients (61 ± 12 years) with atrial fibrillation who underwent RFA procedures...
July 22, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28735371/identifying-symptoms-of-distress-in-youth-living-with-neurofibromatosis-type-1-nf1
#17
Lori Wiener, Haven Battles, Sima Zadeh Bedoya, Andrea Baldwin, Brigitte C Widemann, Maryland Pao
Children and adolescents with Neurofibromatosis type 1 (NF1) are at increased risk for wide-ranging behavioral, developmental, and cognitive impairments and decreased quality of life. To date, no psychosocial screening tool has been developed to quickly assess the symptoms that 1) can be addressed during routine medical appointments in children with NF1, 2) can produce interpretable and actionable results, 3) can be integrated into medical care, and 4) can quickly identify patients at risk in order to better address that the provision of appropriate care are available...
July 23, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28734067/range-instability-leads-to-cytonuclear-discordance-in-a-morphologically-cryptic-ground-squirrel-species-complex
#18
Mark A Phuong, Ke Bi, Craig Moritz
The processes responsible for cytonuclear discordance frequently remain unclear. Here, we employed an exon capture dataset and demographic methods to test hypotheses generated by species distribution models to examine how contrasting histories of range stability vs. fluctuation have caused cytonuclear concordance and discordance in ground squirrel lineages from the Otospermophilus beecheyi species complex. Previous studies in O. beecheyi revealed three morphologically cryptic and highly divergent mitochondrial DNA lineages (named the Northern, Central, and Southern lineages based on geography) with only the Northern lineage exhibiting concordant divergence for nuclear genes...
July 22, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28733155/implementation-of-a-health-information-exchange-into-community-pharmacy-workflow
#19
Kenneth C Hohmeier, Christina A Spivey, Samantha Boldin, Tara B Moore, Marie Chisholm-Burns
OBJECTIVES: To explore the feasibility and report preliminary outcomes of the integration of a health information exchange (HIE) into community pharmacy workflow clinical service delivery. SETTING: Independent pharmacy in eastern Tennessee. PRACTICE DESCRIPTION: The pharmacy offers medication reconciliation services via HIE access, as well as other clinical pharmacy services. The average number of prescriptions filled weekly is 1900, and staffing included 3...
July 18, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28732721/assessing-a-single-targeted-next-generation-sequencing-for-human-leukocyte-antigen-typing-protocol-for-interoperability-as-performed-by-users-with-variable-experience
#20
Manish J Gandhi, Deborah Ferriola, Curt Lind, Jamie L Duke, Anh Huynh, Anna Papazoglou, Kate Mackiewicz, Mette Christiansen, Wei Dong, Susan Hsu, Dawn Thomas, Brittany Schneider, Erin Pierce, Jane Kearns, Malek Kamoun, Dimitri Monos, Medhat Askar
BACKGROUND: A simplified protocol for HLA-typing -by NGS, developed for use with the Illumina MiSeq, was performed by technologists with varying NGS experience to assess accuracy and reproducibility. METHODS: Technologists from six laboratories typed the same 16 samples at HLA-A, B, C, DRB1, and DQB1. The protocol includes long range PCR, library preparation, and paired-end 250bp sequencing. Two indexing strategies were employed: locus-specific indexing whereby each locus was tagged uniquely and sample-specific indexing whereby all 5 loci for a sample were pooled prior to library preparation...
July 18, 2017: Human Immunology
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