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Mucous membrane pemphigoid

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https://www.readbyqxmd.com/read/29752861/immunohistochemical-diagnosis-of-mucous-membrane-pemphigoid
#1
Iakov Shimanovich, Julia Marie Nitz, Mareike Witte, Detlef Zillikens, Christian Rose
BACKGROUND: Mucous membrane pemphigoid (MMP) is an autoimmune subepithelial blistering disease with predominant involvement of mucosal surfaces. It is usually diagnosed by direct immunofluorescence microscopy of frozen biopsies, demonstrating linear deposits of complement, IgG or IgA along the basement membrane. The aim of the present study was to investigate the utility of immunohistochemistry on formalin-fixed, paraffin-embedded tissue biopsies for the diagnosis of MMP and to compare its sensitivity to that of direct immunofluorescence microscopy...
May 12, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29732029/validity-and-reliability-of-the-persian-version-of-the-chronic-oral-mucosal-diseases-questionnaire
#2
Atena Shirzad, Ali Bijani, Mahsa Mehryari, Mina Motallebnejad, Saman Mohsenitavakoli
Background: Chronic oral mucosal disease q uestionnaire (COMDQ) is used to evaluate the quality of life in patients with chronic conditions of the oral mucosa. The aim of the present study was to evaluate the validity and reliability of the Persian version of this questionnaire. Methods: A total of 135 subjects were selected in two groups; group 1 consisted of 95 patients with chronic oral mucosal conditions, including recurrent aphthous stomatitis, oral lichen planus and pemphigus and mucous membrane pemphigoid and group 2 consisted of 40 patients with other oral diseases...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29719538/humoral-epitope-spreading-in-autoimmune-bullous-diseases
#3
REVIEW
Dario Didona, Giovanni Di Zenzo
Autoimmune blistering diseases are characterized by autoantibodies against structural adhesion proteins of the skin and mucous membranes. Extensive characterization of their autoantibody targets has improved understanding of pathogenesis and laid the basis for the study of antigens/epitopes diversification, a process termed epitope spreading (ES). In this review, we have reported and discussed ES phenomena in autoimmune bullous diseases and underlined their functional role in disease pathogenesis. A functional ES has been proposed: (1) in bullous pemphigoid patients and correlates with the initial phase of the disease, (2) in pemphigus vulgaris patients with mucosal involvement during the clinical transition to a mucocutaneous form, (3) in endemic pemphigus foliaceus, underlining its role in disease pathogenesis, and (4) in numerous cases of disease transition associated with an intermolecular diversification of immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29707776/epitope-spread-in-chronic-mucosal-gvhd-mucous-membrane-pemphigoid-resolution-with-rituximab
#4
Sara B Huff, Sumithira Vasu, Benjamin H Kaffenberger
No abstract text is available yet for this article.
April 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29672212/incidence-and-clinical-characteristics-of-ocular-involvement-in-mucous-membrane-pemphigoid
#5
Gloria H Hong, Irfan R Khan, Amde Selassie Shifera, Chinwenwa Okeagu, Jennifer E Thorne
PURPOSE: To describe the risk of developing ocular mucous membrane pemphigoid (MMP) or a new extraocular site of MMP, and to identify risk factors for new involvement. METHODS: Retrospective chart review of 162 biopsy-proven MMP patients. RESULTS: At presentation, 109 of 162 MMP patients (67.3%) had ocular involvement and 53 patients did not. Of the 53 patients without ocular involvement at presentation followed up to 22 years, the risk of developing ocular MMP was 0...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29662486/mucosal-involvement-in-bullous-pemphigoid-is-mostly-associated-with-disease-severity-and-to-absence-of-anti-bp230-autoantibody
#6
Ariane Clapé, Céline Muller, Grégory Gatouillat, Sébastien Le Jan, Coralie Barbe, Bach-Nga Pham, Frank Antonicelli, Philippe Bernard
Bullous pemphigoid (BP) is the most common autoimmune bullous disease and typically affects the elderly. Binding of specific autoantibodies to BP180/230 hemidesmosomal components induces an inflammatory response leading to skin blister formation. Unusual manifestations of BP include additional mucous membrane involvement, without pathophysiological knowledge associated to the formation of these lesions. We here performed a prospective study on series of consecutive BP patients with ( n  = 77) and without ( n  = 18) mucosal involvements at baseline to further investigate why some BP patients display mucosal lesion and other not...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29648673/structured-diagnostic-approach-and-risk-assessment-in-mucous-membrane-pemphigoid-with-oesophageal-involvement
#7
Sandrine Benoit, Michael Scheurlen, Matthias Goebeler, Johanna Stoevesandt
Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29619029/anti-type-vii-collagen-antibodies-are-identified-in-a-subpopulation-of-bullous-pemphigoid-patients-with-relapse
#8
Delphine Giusti, Grégory Gatouillat, Sébastien Le Jan, Julie Plée, Philippe Bernard, Frank Antonicelli, Bach-Nga Pham
Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-type VII collagen AAbs. We therefore evaluated the presence of anti-type VII collagen AAbs in the serum of BP patients with and without mucosal lesions at time of diagnosis and under therapy. Anti-BP180, anti-BP230, and anti-type VII collagen AAbs were measured by ELISA in the serum of unselected patients fulfilling clinical and histo/immunopathological BP criteria at baseline ( n  = 71) and at time of relapse ( n  = 24)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29600832/bullous-pemphigoid-italian-guidelines-adapted-from-edf-eadv-guidelines
#9
Emanuele Cozzani, Angelo V Marzano, Marzia Caproni, Claudio Feliciani, Piergiacomo Calzavara-Pinton
Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localised or generalised bullous lesions. In up to 20% of affected patients blister may be completely absent, and only excoriations, prurigo-like lesions, eczematous lesions, urticated lesions, and/or infiltrated plaques are observed. The disease is significantly associated with neurological disorders. The morbidity of bullous pemphigoid and its impact on the quality of life are significant...
March 30, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29566927/blistering-diseases-in-the-mature-patient
#10
Ines Lakoš Jukić, Sandra Jerković Gulin, Branka Marinović
Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566864/evidence-based-insights-into-the-utility-of-conjunctival-biopsy-in-mucous-membrane-pemphigoid
#11
EDITORIAL
Todd Margolis
No abstract text is available yet for this article.
April 2018: Ophthalmology
https://www.readbyqxmd.com/read/29547128/is-gliclazide-a-new-antidiabetic-drug-implicated-in-the-pathogenesis-of-ocular-mucous-membrane-pemphigoid
#12
Emanuele Cozzani, Giovanni Di Zenzo, Margherita Cioni, Sanja Javor, Marco Altieri, Luca Anselmi, Aurora Parodi
No abstract text is available yet for this article.
March 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29520266/effectiveness-and-safety-of-rituximab-in-recalcitrant-pemphigoid-diseases
#13
Aniek Lamberts, H Ilona Euverman, Jorrit B Terra, Marcel F Jonkman, Barbara Horváth
Introduction: Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited. Objective: To assess the effectiveness and safety of RTX in pemphigoid diseases. Methods: The medical records of 28 patients with pemphigoid diseases that were treated with RTX were reviewed retrospectively...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29490571/vulval-lichen-planus-lichen-sclerosus-overlap
#14
Matthew Howard, Anthony Hall
Vulval lichen planus-lichen sclerosus overlap is an emerging observation. Few clinical reports exist with no reviews of literature. We present a focused update of this phenomenon and discuss a clinical case. We report a 63-year-old woman with a 20-year history of ulcerative vulvo-vaginitis, initially diagnosed as benign mucous membrane (cicatricial) pemphigoid. This led to prolonged treatment with oral corticosteroids with minimal improvement in symptoms. Subsequent complications of long-term use of systemic corticosteroid ensued...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29480624/oral-mucous-membrane-pemphigoid-a-clinical-study-of-100-low-risk-cases
#15
J Bagan, Y Jiménez, J Murillo, L Bagan
OBJECTIVE: To analyze the severity of the oral lesions in low-risk oral mucous membrane pemphigoid (OMMP) measured according to the size of the bullous areas and the number of simultaneously affected oral locations. MATERIAL AND METHODS: A total of 100 cases of low-risk OMMP were studied. The symptoms and location of OMMP in the oral cavity were analyzed. The bullous areas were measured, establishing three grades according to the greatest bullous lesion size (grade 1: < 3 cm in size; grade 2: 3-6 cm; and grade 3: > 6 cm)...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29479786/in-vivo-optical-coherence-tomography-imaging-in-a-case-of-mucous-membrane-pemphigoid-and-a-negative-nikolsky-s-sign
#16
Giorgia Capocasale, Vera Panzarella, Vito Rodolico, Olga Di Fede, Giuseppina Campisi
There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive, repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-year-old patient with desquamative gingivitis. However, a negative Nikolsky's sign did not seem to indicate a diagnosis of mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisional biopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining of tomographic (cross-sectional) scans of tissue...
May 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29473040/direct-immunofluorescence-using-non-lesional-buccal-mucosa-in-mucous-membrane-pemphigoid
#17
Mayumi Kamaguchi, Hiroaki Iwata, Inkin Ujiie, Hideyuki Ujiie, Jun Sato, Yoshimasa Kitagawa, Hiroshi Shimizu
Mucous membrane pemphigoid (MMP) is a rare organ-specific autoimmune subepithelial blistering disease with predominantly mucosal erosions, most frequently affecting the gingiva. Erosions in the oral cavity usually result in markedly decreased quality of life. The major autoantigens are BP180 and laminin332, which are components of basement membrane proteins in the skin and mucosa. Diagnosis is usually difficult due to histological destruction of the tissue and low autoantibody titers. In this study, we evaluated the diagnostic value of direct immunofluorescence (DIF) using non-lesional buccal mucosa in seven cases of MMP...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29443427/intravenous-immunoglobulins-for-rituximab-resistant-mucous-membrane-pemphigoid
#18
LETTER
M Witte, D Zillikens, I Shimanovich
No abstract text is available yet for this article.
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29392620/treatment-of-autoimmune-bullous-disorders-in-pregnancy
#19
REVIEW
Carolyn J Kushner, Josef Symon S Concha, Victoria P Werth
Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations...
February 2, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29387757/successful-treatment-of-mucous-membrane-pemphigoid-with-bortezomib
#20
Lina Saeed, Timothy H Schmidt, Lianne S Gensler, Andrew J Gross, Lindy P Fox, Tiffany C Scharschmidt, Karin Gaensler, Haley Naik, Michael A Rosenblum, Kanade Shinkai
No abstract text is available yet for this article.
January 2018: JAAD Case Reports
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