keyword
MENU ▼
Read by QxMD icon Read
search

Complex I

keyword
https://www.readbyqxmd.com/read/28655193/the-importance-of-fermentative-conditions-for-the-biotechnological-production-of-lignin-modifying-enzymes-from-white-rot-fungi
#1
Francesca Martani, Fabrizio Beltrametti, Danilo Porro, Paola Branduardi, Marina Lotti
White-rot fungi are the main natural producers of lignin modifying enzymes, i.e. laccases and peroxidases, whose secretion and activity allows the depolymerization of lignin and the release of polysaccharides contained in lignocellulose. These enzymes are able to oxidize, in addition to lignin, a wide spectrum of natural and synthetic substrates, making their industrial and biotechnological application appealing. However, the complex regulation of the synthesis of lignin modifying enzymes, as well as the heterogeneous physiology of fungi in response to nutrients, make the use of white-rot fungi as production platforms challenging...
June 26, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28655162/the-role-of-older-persons-environment-in-aging-well-quality-of-life-illness-and-community-context-in-south-africa
#2
Margaret Ralston
Purpose of the Study: This article evaluates the influence of local district conditions on subjective quality of life of older South African adults. Policymakers increasingly recognize that "successful" aging policies must not only address physical health needs but also factors that influence subjective well-being. Design and Methods: To investigate the influence of area-level distribution of "public goods" on well-being in a low- and middle-income setting, nationally representative WHO-Study of Global AGEing and Adult Health (WHO-SAGE) survey data is combined with district-level data that captures built resources and health system distribution...
June 24, 2017: Gerontologist
https://www.readbyqxmd.com/read/28655069/delivery-of-parasite-cdg7_flc_0990-rna-transcript-into-intestinal-epithelial-cells-during-cryptosporidium-parvum-infection-suppresses-host-cell-gene-transcription-through-epigenetic-mechanisms
#3
Yang Wang, Ai-Yu Gong, Shibin Ma, Xiqiang Chen, Juliane K Strauss-Soukup, Xian-Ming Chen
Cryptosporidial infection causes dysregulated transcription of host genes key to intestinal epithelial homeostasis, but the underlying mechanisms remain obscure. Previous studies demonstrate that several C. parvum RNA transcripts are selectively delivered into epithelial cells during host cell invasion and may modulate gene transcription in infected cells. We report here that C. parvum infection suppresses the transcription of LRP5, SLC7A8, and IL33 genes in infected intestinal epithelium. Trans-suppression of these genes in infected host cells is associated with promoter enrichment of suppressive epigenetic markers (i...
June 27, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28654735/controlling-regioselectivity-in-the-enantioselective-n-alkylation-of-indole-analogs-catalyzed-by-dinuclear-zinc-prophenol
#4
Barry M Trost, Elumalai Gnanamani, Chao-I Joey Hung
The enantioselective N-alkylation of indole and its derivatives with aldimines is efficiently catalyzed by a zinc-ProPhenol dinuclear complex under mild conditions to afford N-alkylated indole derivatives in good yield (up to 86%) and excellent enantiomeric ratio (up to 99.5: 0.5 e.r.). This protocol tolerates a wide array of indoles, as well as pyrrole and carbazole, to afford the corresponding N-alkylation products. The reaction can be run on gram scale with reduced catalyst loading without impacting the efficiency...
June 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28654729/signor-a-database-of-causal-relationships-between-biological-entities-a-short-guide-to-searching-and-browsing
#5
Prisca Lo Surdo, Alberto Calderone, Gianni Cesareni, Livia Perfetto
SIGNOR (http://signor.uniroma2.it), the SIGnaling Network Open Resource, is a database designed to store experimentally validated causal interactions, i.e., interactions where a source entity has a regulatory effect (up-regulation, down-regulation, etc.) on a second target entity. SIGNOR acts both as a source of signaling information and a support for data analysis, modeling, and prediction. A user-friendly interface features the ability to search entries for any given protein or group of proteins and to display their interactions graphically in a network view...
June 27, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28654557/the-effectiveness-of-transcranial-direct-current-stimulation-as-an-add-on-modality-to-graded-motor-imagery-for-treatment-of-complex-regional-pain-syndrome-a-randomized-proof-of-concept-study
#6
Émilie Lagueux, Michaël Bernier, Patricia Bourgault, Kevin Whittingstall, Catherine Mercier, Guillaume Léonard, Sarah Laroche, Yannick Tousignant-Laflamme
BACKGROUND: The efficacy of graded motor imagery (GMI) for the management of complex regional pain syndrome (CRPS) is supported by evidence, but its treatment effect remains generally modest. Transcranial direct current stimulation (tDCS) has been advocated as an adjunct intervention to enhance the effect of motor imagery approaches in pain populations. OBJECTIVE: The purpose of this study was to investigate the effectiveness of GMI+active tDCS compared to the GMI+sham tDCS in the treatment of CRPS type I...
June 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28654233/interfacial-manipulation-by-rutile-tio2-nanoparticles-to-boost-co2-reduction-into-co-on-a-metal-complex-semiconductor-hybrid-photocatalyst
#7
Keisuke Wada, Chandana Sampath Kumara Ranasinghe, Ryo Kuriki, Akira Yamakata, Osamu Ishitani, Kazuhiko Maeda
Metal-complex/semiconductor hybrids have attracted attention as photocatalysts for visible-light CO2 reduction, and electron transfer from metal complex to semiconductor is critically important to improve the performance. Here rutile TiO2 nanoparticles having 5-10 nm in size were employed as modifiers to improve interfacial charge transfer between semiconducting carbon nitride nanosheets (NS-C3N4) and a supramolecular Ru(II)-Re(I) binuclear complex (RuRe). The RuRe/TiO2/NS-C3N4 hybrid was capable of photocatalyzing CO2 reduction into CO with high selectivity under visible light (λ > 400 nm), outperforming an analogue without TiO2 by a factor of 4, in terms of both CO formation rate and turnover number (TON)...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28654077/protocol-for-the-differentiation-of-human-induced-pluripotent-stem-cells-into-mixed-cultures-of-neurons-and-glia-for-neurotoxicity-testing
#8
Francesca Pistollato, David Canovas-Jorda, Dimitra Zagoura, Anna Price
Human pluripotent stem cells can differentiate into various cell types that can be applied to human-based in vitro toxicity assays. One major advantage is that the reprogramming of somatic cells to produce human induced pluripotent stem cells (hiPSCs) avoids the ethical and legislative issues related to the use of human embryonic stem cells (hESCs). HiPSCs can be expanded and efficiently differentiated into different types of neuronal and glial cells, serving as test systems for toxicity testing and, in particular, for the assessment of different pathways involved in neurotoxicity...
June 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653980/ligand-shaping-in-induced-fit-docking-of-mray-inhibitors-polynomial-discriminant-and-laplacian-operator-as-biological-activity-descriptors
#9
Claudiu N Lungu, Mircea V Diudea, Mihai V Putz
Docking-i.e., interaction of a small molecule (ligand) with a proteic structure (receptor)-represents the ground of drug action mechanism of the vast majority of bioactive chemicals. Ligand and receptor accommodate their geometry and energy, within this interaction, in the benefit of receptor-ligand complex. In an induced fit docking, the structure of ligand is most susceptible to changes in topology and energy, comparative to the receptor. These changes can be described by manifold hypersurfaces, in terms of polynomial discriminant and Laplacian operator...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28653974/hla-g-3-utr-polymorphisms-predict-drug-induced-g3-4-toxicity-related-to-folinic-acid-5-fluorouracil-oxaliplatin-folfox4-chemotherapy-in-non-metastatic-colorectal-cancer
#10
Marica Garziera, Saverio Virdone, Elena De Mattia, Lucia Scarabel, Erika Cecchin, Jerry Polesel, Mario D'Andrea, Nicoletta Pella, Angela Buonadonna, Adolfo Favaretto, Giuseppe Toffoli
Polymorphisms in drug-metabolizing enzymes might not completely explain inter-individual differences in toxicity profiles of patients with colorectal cancer (CRC) that receive folinic acid/5-fluorouracil/oxaliplatin (FOLFOX4). Recent data indicate that the immune system could contribute to FOLFOX4 outcomes. In light of the immune inhibitory nature of human leukocyte antigen-G (HLA-G), a non-classical major histocompatibility complex (MHC) class I molecule, we aimed to identify novel genomic markers of grades 3 and 4 (G3-4) toxicity related to FOLFOX4 therapy in patients with CRC...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28653922/complexation-of-ibuprofen-with-water-soluble-p-sulfonatocalix-4-arene-a-potential-candidate-for-drug-delivery-applicatio
#11
Tahira S Khokhar, Shahabuddin Memon, Qadeer K Panhwar, Fakhar N Memon, Ayaz A Memon, Muhammad Qasim Samejo, Saba Muneer, Metin Tulu
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. δG, ΔH and δS have been found as -24...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653021/ligand-manipulation-of-charge-transfer-excited-state-relaxation-and-spin-crossover-in-fe-2-2-bipyridine-2-cn-2
#12
Kasper S Kjær, Wenkai Zhang, Roberto Alonso-Mori, Uwe Bergmann, Matthieu Chollet, Ryan G Hadt, Robert W Hartsock, Tobias Harlang, Thomas Kroll, Katharina Kubiček, Henrik T Lemke, Huiyang W Liang, Yizhu Liu, Martin M Nielsen, Joseph S Robinson, Edward I Solomon, Dimosthenis Sokaras, Tim B van Driel, Tsu-Chien Weng, Diling Zhu, Petter Persson, Kenneth Wärnmark, Villy Sundström, Kelly J Gaffney
We have used femtosecond resolution UV-visible and Kβ x-ray emission spectroscopy to characterize the electronic excited state dynamics of [Fe(bpy)2(CN)2], where bpy=2,2'-bipyridine, initiated by metal-to-ligand charge transfer (MLCT) excitation. The excited-state absorption in the transient UV-visible spectra, associated with the 2,2'-bipyridine radical anion, provides a robust marker for the MLCT excited state, while the transient Kβ x-ray emission spectra provide a clear measure of intermediate and high spin metal-centered excited states...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28652867/scattered-genomic-amplification-in-dedifferentiated-liposarcoma
#13
Nils Mandahl, Linda Magnusson, Jenny Nilsson, Björn Viklund, Elsa Arbajian, Fredrik Vult von Steyern, Anders Isaksson, Fredrik Mertens
BACKGROUND: Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations than supernumerary ring or giant marker chromosomes, although DDLS tend to have somewhat more complex rearrangements. In contrast, pleomorphic liposarcomas (PLS) have highly aberrant and heterogeneous karyotypes. The ring and giant marker chromosomes contain discontinuous amplicons, in particular including multiple copies of the target genes CDK4, HMGA2 and MDM2 from 12q, but often also sequences from other chromosomes...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28652620/differential-cohesin-loading-marks-paired-and-unpaired-regions-of-platypus-sex-chromosomes-at-prophase-i
#14
Aaron E Casey, Tasman J Daish, Jose Luis Barbero, Frank Grützner
Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex sex chromosome system, which raises fundamental questions about organisation and segregation during meiosis. We discovered a dynamic and differential accumulation of cohesins on sex chromosomes during platypus prophase I and specific reorganisation of the sex chromosome complex around a large nucleolar body...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652491/quantum-communication-with-coherent-states-of-light
#15
REVIEW
Imran Khan, Dominique Elser, Thomas Dirmeier, Christoph Marquardt, Gerd Leuchs
Quantum communication offers long-term security especially, but not only, relevant to government and industrial users. It is worth noting that, for the first time in the history of cryptographic encoding, we are currently in the situation that secure communication can be based on the fundamental laws of physics (information theoretical security) rather than on algorithmic security relying on the complexity of algorithms, which is periodically endangered as standard computer technology advances. On a fundamental level, the security of quantum key distribution (QKD) relies on the non-orthogonality of the quantum states used...
August 6, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28652405/mechanism-of-pathogen-recognition-by-human-dectin-2
#16
Hadar Feinberg, Sabine A F Jégouzo, Maximus J Rex, Kurt Drickamer, William I Weis, Maureen E Taylor
Dectin-2, a C-type lectin on macrophages and other cells of the innate immune system, functions in responses to pathogens, particularly fungi. The carbohydrate-recognition domain (CRD) in dectin-2 is linked to a transmembrane sequence that interacts with the common FcRγ subunit to initiate immune signaling. The molecular mechanism by which dectin-2 selectively binds to pathogens has been investigated by characterizing the CRD expressed in a bacterial system. Competition binding studies indicated that the CRD binds to monosaccharides with modest affinity and that affinity is greatly enhanced for mannose linked α1-2 or α1-4 to a second mannose residue...
June 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28652146/downregulation-of-pkc%C3%AE-pard3-pard6b-is-responsible-for-lung-adenocarcinoma-cell-emt-and-invasion
#17
Qiyuan Zhou, Jingbo Dai, Tianji Chen, Laura A Dada, Xu Zhang, Wei Zhang, Malcolm M DeCamp, Robert A Winn, Jacob I Sznajder, Guofei Zhou
Atypical protein kinase C ζ (PKCζ) forms an apico-basal polarity complex with Partitioning Defective (Pard) 3 and Pard6 to regulate normal epithelial cell apico-basolateral polarization. The dissociation of the PKCζ/Pard3/Pard6 complex is essential for the disassembly of the tight/adherens junction and epithelial-mesenchymal transition (EMT) that is critical for tumor spreading. Loss of cell polarity and epithelial organization is strongly correlated with malignancy and tumor progression in some other cancer types...
June 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28652106/show-me-your-tenent-setae-and-i-tell-you-who-you-are-telling-the-story-of-a-neglected-character-complex-with-phylogenetic-signals-using-leiodidae-coleoptera-as-a-case-study
#18
Pedro Gnaspini, Caio Antunes-Carvalho, Alfred F Newton, Richard A B Leschen
The tarsal setae in 97 species of Leiodidae and eight outgroups were examined using SEM imaging and dissections. Modified adhesive setae present in males are referred to as "male tenent setae" (MTS). In most cases, dilated tarsomeres were associated with MTS, which were always present on the protarsi and sometimes the mesotarsi. MTS are reported for the first time on the mesotarsi of Leptodirini and on the metatarsi in two genera of Sogdini. Contrary to reports in the literature, the reduction in the number of the MTS bearing mesotarsomeres is considered a derived condition...
June 23, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/28652003/comprehensive-two-dimensional-gas-chromatography-mass-spectrometry-of-complex-mixtures-of-anaerobic-bacterial-metabolites-of-petroleum-hydrocarbons
#19
C M Aitken, I M Head, D M Jones, S J Rowland, A G Scarlett, C E West
Anaerobic biotransformation of petroleum hydrocarbons is an important alteration mechanism, both subsurface in geological reservoirs, in aquifers and in anoxic deep sea environments. Here we report the resolution and identification, by comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS), of complex mixtures of aromatic acid and diacid metabolites of the anaerobic biodegradation of many crude oil hydrocarbons. An extended range of metabolites, including alkylbenzyl, alkylindanyl, alkyltetralinyl, alkylnaphthyl succinic acids and alkyltetralin, alkylnaphthoic and phenanthrene carboxylic acids, is reported in samples from experiments conducted under sulfate-reducing conditions in a microcosm over two years...
June 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28651965/single-molecule-fluorescence-in-situ-hybridisation-for-quantitating-post-transcriptional-regulation-in-drosophila-brains
#20
Lu Yang, Josh Titlow, Darragh Ennis, Carlas Smith, Jessica Mitchell, Florence L Young, Scott Waddell, David Ish-Horowicz, Ilan Davis
RNA in situ hybridization is a powerful method to investigate post-transcriptional regulation, but analysis of intracellular mRNA distributions in thick, complex tissues like the brain poses significant challenges. Here, we describe the application of single-molecule fluorescent in situ hybridization (smFISH) to quantitate primary nascent transcription and post-transcriptional regulation in whole-mount Drosophila larval and adult brains. Combining immunofluorescence and smFISH probes for different regions of a single gene, i...
June 23, 2017: Methods: a Companion to Methods in Enzymology
keyword
keyword
11012
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"