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Complex I

Manda Curic, Marina Juribašić Kulcar, Alen Bjelopetrović, Stipe Lukin, Ivan Halasz, Krunoslav Užarević, Ivica Đilović, Dajana Barišić, Ana Budimir
Mechanism of C-H bond activation by various Pd(II) catalysts under milling conditions has been studied by in situ Raman spectroscopy. Common Pd(II) precursors, i.e. PdCl₂, [Pd(OAc)₂]₃, PdCl₂(MeCN)₂ and [Pd(MeCN)₄][BF₄]₂, have been employed for the activation of one or two C-H bonds in an unsymmetrical azobenzene substrate. The C-H activation was achieved by all used Pd(II) precursors and their reactivity increases in the order [Pd(OAc)₂]₂ < PdCl₂(MeCN)₂ < PdCl₂ < [Pd(MeCN)₂][BF₄]₂...
June 19, 2018: Chemistry: a European Journal
Xingliang Li, Zhicheng Zhang, Leigh R Martin, Shunzhong Luo, Linfeng Rao
N-(2-Hydroxyethyl)ethylenediamine- N, N', N'-triacetic acid (HEDTA, denoted as H3 L in this work, and the three dissociable protons represent those of the three carboxylic groups) is a strong chelating ligand and plays an important role in the treatment and disposal of nuclear wastes as well as separation sciences of f-elements. In this work, the complexation of HEDTA with U(VI) was studied thermodynamically and structurally in aqueous solutions. Potentiometry and microcalorimetry were used to measure the complexation constants (298-343 K) and enthalpies (298 K), respectively, at I = 1...
June 19, 2018: Inorganic Chemistry
Tian-Sheng He, Tian Chen, Dan-Dan Wang, Liang-Guo Xu
Mitochondrial anti‑viral signaling protein (VISA), additionally termed MAVS, IPS‑1 and Cardif, is located at the outer membrane of mitochondria and is an essential adaptor in the Rig‑like receptor (RLRs) signaling pathway. Upon viral infection, activated RLRs interact with VISA on mitochondria, forming a RLR‑VISA platform, leading to the recruitment of different TRAF family members, including TRAF3, TRAF2 and TRAF6. This results in the phosphorylation and nuclear translocation of interferon regulatory factors 3 and 7 (IRF3/IRF7) by TANK binding kinase 1 (TBK1) and/or IKKε, as well as activation of NF‑κB, to induce type I interferons (IFNs) and pro‑inflammatory cytokines...
June 15, 2018: Molecular Medicine Reports
Xue Jing, Zibin Tian, Pujun Gao, Huashi Xiao, Xiaolong Qi, Yanan Yu, Xueli Ding, Lin Yang, Liang Zong
Chronic hepatitis B virus (HBV) infection remains one of the leading causes of hepatocellular carcinoma (HCC) globally. However, the mechanism underlying the mediation by HBV surface proteins (HBsAgs) of the early steps in the virus life cycle and following HCC development is unclear. β‑2‑glycoprotein I (β2GPI) specifically interacts with HBsAg and demonstrates high expression during the earliest stages of hepatitis B virus infection. In the present study, the assessment of HCC and adjacent tissues revealed that the levels of mRNA and protein of β2GPI were highly expressed in HBV‑related HCC...
June 19, 2018: Oncology Reports
Elaheh Pousaneh, Marcus Korb, Volodymyr Dzhagan, Marcus Weber, Julian Noll, Michael Mehring, Dietrich R T Zahn, Stefan E Schulz, Heinrich Lang
The synthesis of ketoiminato copper(ii) complexes [Cu(OCRCHC(CH3)NCH2CH2X)(μ-OAc)]2 (X = NMe2: 4a, R = Me; 4b, R = Ph. X = OMe: 5, R = Me) and [Cu(OCRCHCMeNCH2CH2NEt2)(OAc)] (6, R = Me) from RC(O)CHC(CH3)N(H)CH2CH2X (X = NMe2: 1a, R = Me; 1b, R = Ph. X = NEt2: 1c, R = Me. X = OMe: 2, R = Me) and [Cu(OAc)2·H2O] (3) is reported. The molecular solid-state structures of 4-6 were determined by single crystal X-ray diffraction studies, showing that 4a,b and 5 are dimers which are set up by two [{Cu(μ-OAc)L}] (L = ketoiminato ligand) units featuring a square-planar Cu2O2 core with a distorted square-pyramidal geometry at Cu(ii)...
June 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Gabriele Dalla Torre, Jon I Mujika, Elena Formoso, Eduard Matito, Maria J Ramos, Xabier Lopez
Due to aluminum's controversial role in neurotoxicity, the goal of chelation therapy, the removal of the toxic metal ion or attenuation of its toxicity by transforming it into less toxic compounds, has attracted considerable interest in the past years. In the present paper we present, validate and apply a state-of-the-art theoretical protocol suitable for the characterization of the interactions between a chelating agent and Al(iii). In particular, we employ a cluster-continuum approach based on Density Functional Theory calculations to evaluate the binding affinity of aluminum for a set of two important families of aromatic chelators: salicylic acids and catechols...
June 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Lokesh D Kori, Neena Valecha, Anupkumar R Anvikar
Even though malaria is preventable and curable, it has become a serious threat to mankind. In 2016, there were an estimated 216 million cases of malaria across the world. The biology of its causative agent, i.e. Plasmodium parasite is full of complex mechanisms. There are five Plasmodium species responsible for malaria in humans, viz. Plasmodium falciparum, P. vivax, P. malariae, P. ovale and recently identified P. knowlesi that normally infect apes. In humans, malaria is spread by the injection of Plasmodium sporozoites through the bite of infectious Anopheles' female mosquito during their blood meal...
January 2018: Journal of Vector Borne Diseases
Karen M Wassarman
6S RNA is a small RNA regulator of RNA polymerase (RNAP) that is present broadly throughout the bacterial kingdom. Initial functional studies in Escherichia coli revealed that 6S RNA forms a complex with RNAP resulting in regulation of transcription, and cells lacking 6S RNA have altered survival phenotypes. The last decade has focused on deepening the understanding of several aspects of 6S RNA activity, including (i) addressing questions of how broadly conserved 6S RNAs are in diverse organisms through continued identification and initial characterization of divergent 6S RNAs; (ii) the nature of the 6S RNA-RNAP interaction through examination of variant proteins and mutant RNAs, cross-linking approaches, and ultimately a cryo-electron microscopic structure; (iii) the physiological consequences of 6S RNA function through identification of the 6S RNA regulon and promoter features that determine 6S RNA sensitivity; and (iv) the mechanism and cellular impact of 6S RNA-directed synthesis of product RNAs (i...
May 2018: Microbiology Spectrum
Jordi Mestre, Anton Lishchynskyi, Sergio Castillón, Omar Boutureira
We herein present a flexible approach for the introduction of CF3 units into a predefined site of electron-rich alkenes that exploits the regiocontrolled introduction of an iodine handle and subsequent trifluoromethylation of the C(sp2 )-I bond using fluoroform-derived "ligandless" CuCF3 . The broad substrate scope and functional group tolerance together with the scalability and purity of the resulting products enabled the controlled, late-stage synthesis of single regioisomers of complex CF3 -scaffolds such as sugars, nucleosides (antivirals), and heterocycles (indoles, chromones) with potential for academic and industrial applications...
June 19, 2018: Journal of Organic Chemistry
Pengying Liao, Xiongdiao Lan, Dankui Liao, LiXia Sun, Liqin Zhou, Jianhua Sun, Zhangfa Tong
Carapax Trionycis (the shell of the turtle Pelodiscus sinensis) was hydrolyzed by six different commercial proteases. The hydrolysate prepared from papain showed stronger inhibitory activity against angiotensin I-converting enzyme (ACE) than other extracts. Two noncompetitive ACE inhibitory peptides were purified successively by ultrafiltration, gel filtration chromatography, ion exchange column chromatography, and high-performance liquid chromatography (HPLC). The amino acid sequences of them were identified as KRER and LHMFK, with IC50 values of 324...
June 19, 2018: Journal of Agricultural and Food Chemistry
Ryoichi Sato, Rinya Kawashima, Mai Duy Luu Trinh, Masahiro Nakano, Takeharu Nagai, Shinji Masuda
The proton motive force (PMF) across the chloroplast thylakoid membrane that is generated by electron transport during photosynthesis is the driving force for ATP synthesis in plants. The PMF mainly arises from the oxidation of water in photosystem II and from electron transfer within the cytochrome b6 f complex. There are two electron transfer pathways related to PMF formation: linear electron flow and cyclic electron flow. Proton gradient regulation 5 (PGR5) is a major component of the cyclic electron flow pathway, and the Arabidopsis pgr5 mutant shows a substantial reduction in the PMF...
June 18, 2018: Photosynthesis Research
Diego A Martinez, Erin M Kane, Mehdi Jalalpour, James Scheulen, Hetal Rupani, Rohit Toteja, Charles Barbara, Bree Bush, Scott R Levin
Efforts to monitoring and managing hospital capacity depend on the ability to extract relevant time-stamped data from electronic medical records and other information technologies. However, the various characterizations of patient flow, cohort decisions, sub-processes, and the diverse stakeholders requiring data visibility create further overlying complexity. We use the Donabedian model to prioritize patient flow metrics and build an electronic dashboard for enabling communication. Ten metrics were identified as key indicators including outcome (length of stay, 30-day readmission, operating room exit delays, capacity-related diversions), process (timely inpatient unit discharge, emergency department disposition), and structural metrics (occupancy, discharge volume, boarding, bed assignation duration)...
June 18, 2018: Journal of Medical Systems
Shailendra Kumar Mishra, Mona Srivastava, Narendra K Tiwary, Abhinit Kumar
Background: Psychiatric morbidity in children and adolescents is a major concern as they become more complex and intense with children's transition into adolescence. Aim: The aim of this study is to assess and compare the prevalence of depression and anxiety among children residing in rural and suburban area of eastern Uttar Pradesh and understand the burden of these problems in our society. Materials and Methods: Children, in the age group 11-18 years, were divided into 2 groups: Group I - 100 children from rural area Tikri; Group II - 100 children from suburban area Sunderpur...
January 2018: Journal of Family Medicine and Primary Care
Xu Nan, Zhang Huihui, Zhong Haixiu, Wu Yining, Li Jinbo, Xin Li, Yin Zepeng, Zhu Wenxu, Qu Yi, Sun Guangyu
This paper selected clonal cutting seedlings from the F1 hybrid varieties of Physocarpus amurensis Maxim (♀) × P. opulifolius "Diabolo" (♂) as research material to study the response of the photosynthetic gas exchange parameters and chlorophyll fluorescence parameters of P. amurensis hybrids and their parental leaves to NaCl stress (with concentrations of 0, 50, 100, and 200 mmol⋅L-1 ). The results showed that under salt stress, the stomatal conductance ( G s ), transpiration rate ( T r ), and net photosynthetic rate ( P n ) of the three kinds of P...
2018: Frontiers in Plant Science
Chatchai Phoomak, Atit Silsirivanit, Dayoung Park, Kanlayanee Sawanyawisuth, Kulthida Vaeteewoottacharn, Chaisiri Wongkham, Eric W-F Lam, Chawalit Pairojkul, Carlito B Lebrilla, Sopit Wongkham
The leading cause of death in cancer patients is metastasis, for which an effective treatment is still necessary. During metastasis, cancer cells aberrantly express several glycans that are correlated with poor patient outcome. This study was aimed toward exploring the effects of O-GlcNAcylation on membranous N-glycans that are associated with the progression of cholangiocarcinoma (CCA). Global O-GlcNAcylation in CCA cells was depleted using specific siRNA against O-GlcNAc transferase (OGT), which transfers GlcNAc to the acceptor proteins...
June 18, 2018: Oncogene
Ahmed-Noor A Agip, James N Blaza, Hannah R Bridges, Carlo Viscomi, Shaun Rawson, Stephen P Muench, Judy Hirst
Complex I (NADH:ubiquinone oxidoreductase) uses the reducing potential of NADH to drive protons across the energy-transducing inner membrane and power oxidative phosphorylation in mammalian mitochondria. Recent cryo-EM analyses have produced near-complete models of all 45 subunits in the bovine, ovine and porcine complexes and have identified two states relevant to complex I in ischemia-reperfusion injury. Here, we describe the 3.3-Å structure of complex I from mouse heart mitochondria, a biomedically relevant model system, in the 'active' state...
June 18, 2018: Nature Structural & Molecular Biology
Amin Ghadami, Eleni Gourgou, Bogdan I Epureanu
Anticipating critical transitions in complex ecological and living systems is an important need because it is often difficult to restore a system to its pre-transition state once the transition occurs. Recent studies demonstrate that several indicators based on changes in ecological time series can indicate that the system is approaching an impending transition. An exciting question is, however, whether we can predict more characteristics of the future system stability using measurements taken away from the transition...
June 18, 2018: Scientific Reports
S W Fanning, L Hodges-Gallagher, D C Myles, R Sun, C E Fowler, I N Plant, B D Green, C L Harmon, G L Greene, P J Kushner
Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however an absence of structural information hinders the development of novel candidates. Here we synthesize a small panel of benzopyrans with variable side chains to identify pure antiestrogens in a uterotrophic assay...
June 18, 2018: Nature Communications
Raj K Gopal, Sarah E Calvo, Angela R Shih, Frances L Chaves, Declan McGuone, Eran Mick, Kerry A Pierce, Yang Li, Andrea Garofalo, Eliezer M Van Allen, Clary B Clish, Esther Oliva, Vamsi K Mootha
Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis of these tumors. Joint analysis of the nuclear and mitochondrial (mtDNA) genomes reveals loss-of-function mtDNA mutations occurring at high variant allele fractions, consistent with positive selection, in genes encoding complex I as the most frequent genetic events. A subset of these tumors also exhibits chromosome 1 loss and/or cyclin D1 overexpression, suggesting they follow complex I loss...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Tatsuya Sato, Hsiang-Chun Chang, Marina Bayeva, Jason S Shapiro, Lucia Ramos-Alonso, Hidemichi Kouzu, Xinghang Jiang, Ting Liu, Sumeyye Yar, Konrad T Sawicki, Chunlei Chen, María Teresa Martínez-Pastor, Deborah J Stumpo, Paul T Schumacker, Perry J Blackshear, Issam Ben-Sahra, Sergi Puig, Hossein Ardehali
Cells respond to iron deficiency by activating iron-regulatory proteins to increase cellular iron uptake and availability. However, it is not clear how cells adapt to conditions when cellular iron uptake does not fully match iron demand. Here, we show that the mRNA-binding protein tristetraprolin (TTP) is induced by iron deficiency and degrades mRNAs of mitochondrial Fe/S-cluster-containing proteins, specifically Ndufs1 in complex I and Uqcrfs1 in complex III, to match the decrease in Fe/S-cluster availability...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
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