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https://www.readbyqxmd.com/read/29458137/bisphenol-a-alters-oocyte-maturation-by-prematurely-closing-gap-junctions-in-the-cumulus-cell-oocyte-complex
#1
Deyanira Guadalupe Acuña-Hernández, Laura Arreola-Mendoza, Ramsés Santacruz-Márquez, Sihomara Patricia García-Zepeda, Lyda Yuliana Parra-Forero, Jesús Alberto Olivares-Reyes, Isabel Hernández-Ochoa
In ovarian follicles, cumulus cells communicate with the oocyte through gap junction intercellular communication (GJIC), to nurture the oocyte and control its meiosis arrest and division. Bisphenol A (BPA) is a monomer found in polycarbonate-made containers that can induce functional alterations, including impaired oocyte meiotic division and reduced molecule transfer in GJIC. However, how BPA alters oocyte meiotic division is unclear. We investigated whether BPA effects on oocyte meiotic division were correlated with reduced transfer in GJIC...
February 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29458114/severity-dependent-influence-of-isocapnic-hypoxia-on-reaction-time-is-independent-of-neurovascular-coupling
#2
Hannah G Caldwell, Geoff B Coombs, Michael M Tymko, Daniela Nowak-Flück, Philip N Ainslie
With exposure to acute normobaric hypoxia, global cerebral oxygen delivery is maintained via increases in cerebral blood flow (CBF); therefore, regional and localized changes in oxygen tension may explain neurocognitive impairment. Neurovascular coupling (NVC) is the close temporal and regional relationship of CBF to changes in neural activity and may aid in explaining the localized CBF response with cognitive activation. High-altitude related cognitive impairment is likely affected by hypocapnic cerebral vasoconstriction that may influence regional CBF regulation independent of hypoxia...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458112/compatible-osmolytes-modulate-mitochondrial-function-in-a-marine-osmoconformer-crassostrea-gigas-thunberg-1793
#3
Eugene P Sokolov, Inna M Sokolova
Salinity is an important environmental factor affecting physiology of marine organisms. Osmoconformers such as marine mollusks maintain metabolic function despite changes of the osmolarity and composition of the cytosol during salinity shifts. Currently, metabolic responses to the salinity-induced changes of the intracellular milieu are not well understood. We studied the effects of osmolarity (450 vs. 900 mOsm) and compatible osmolytes (70-590 mM of taurine or betaine) on isolated gill mitochondria of a marine osmoconformer, the Pacific oyster Crassostrea gigas...
February 16, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29458092/ramifications-of-the-children-s-surgery-verification-program-for-patients-and-hospitals
#4
Katherine J Baxter, Bonnie F Gale, Curtis D Travers, Kurt F Heiss, Mehul V Raval
BACKGROUND: The American College of Surgeons in 2015 instituted the Children's Surgery Verification (CSV) program delineating requirements for hospitals providing pediatric surgical care. Our purpose was to examine possible effects of the CSV program by evaluating neonates undergoing high-risk operations. STUDY DESIGN: Using the Kid's Inpatient Database 2009, we identified infants undergoing surgery for five high risk neonatal conditions. We considered all children's hospitals and children's units Level I centers and considered all others Level II/III...
February 16, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29458077/reciprocal-regulation-of-the-cadherin-11-stat3-axis-by-caveolin-1-in-mouse-fibroblasts-and-lung-carcinoma-cells
#5
M Geletu, R Mohan, R Arulanandam, A Berger-Becvar, I R Nabi, P T Gunning, L Raptis
Caveolin-1 (Cav1) is an integral plasma membrane protein and a complex regulator of signal transduction. The Signal Transducer and Activator of Transcription-3 (Stat3) is activated by a number of receptor and non-receptor tyrosine kinases and is positively implicated in cancer. Despite extensive efforts, the relationship between Cav1 and Stat3 has been a matter of controversy. We previously demonstrated that engagement of E- or N-cadherin or cadherin-11 cell to cell adhesion molecules, as occurs with confluence of cultured cells, triggers a dramatic increase in the levels of tyr705 phosphorylated ie activated Stat3, by a mechanism requiring the cRac1 small GTPase...
February 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29457977/single-molecule-centroid-localization-algorithm-improves-the-accuracy-of-fluorescence-binding-assays
#6
Boyang Hua, Yanbo Wang, Seongjin Park, Kyu Young Han, Digvijay Singh, Jin Hyun Kim, Wei Cheng, Taekjip Ha
Here, we demonstrate that the use of single-molecule centroid localization algorithm can improve the accuracy of fluorescence binding assays. Two major artifacts in this type of assays, i.e., non-specific binding events and optically overlapping receptors, can be detected and corrected during analysis. The effectiveness of our method was confirmed by measuring two weak biomolecular interactions, the interaction between the B1 domain of streptococcal protein G (pGB1) and immunoglobulin G (IgG), and the one between double-stranded DNA (dsDNA) and the Cas9-RNA complex with limited sequence matches...
February 19, 2018: Biochemistry
https://www.readbyqxmd.com/read/29457946/the-provision-of-ambulatory-systemic-anti-cancer-therapy
#7
Susan Cooper, Kate de Lord
This article reflects on the changing nature of the provision of care and delivery of ambulatory systemic anti-cancer therapy (SACT) services. It reviews the national guidance and looks at ambulatory SACT in terms of patients being treated closer to home, i.e. ambulatory care in its truest sense. It considers the impact on quality of life for patients receiving treatments at a place of their choice. It explores the role of the nurse as an advanced practitioner while also examining the safety and delivery of complex regimens ensuring robust pathways are in place to deliver care in a safe and standardised way...
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457892/boronic-acid-catalyzed-regio-and-1-2-cis-stereoselective-glycosylation-of-unprotected-sugar-acceptors-via-s-n-i-type-mechanism
#8
Masamichi Tanaka, Akira Nakagawa, Nobuya Nishi, Kiyoko Iijima, Ryuichi Sawa, Daisuke Takahashi, Kazunobu Toshima
Regio- and 1,2-cis-stereoselective chemical glycosylation of unprotected glycosyl acceptors has been in great demand for the efficient synthesis of natural glycosides. However, simultaneously regulating these selectivities has been a long-standing problem in synthetic organic chemistry. In nature, glycosyl transferases catalyze regioselective 1,2-cis-glycosylations via the SN i mechanism, yet no useful chemical glycosylations based on this mechanism have been developed. In this paper, we report a highly regio- and 1,2-cis-stereoselective SN i-type glycosylation of 1,2-anhydro donors and unprotected sugar acceptors using p-nitrophenylboronic acid (10e) as a catalyst in the presence of water under mild conditions...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29457807/copper-i-and-silver-i-complexes-of-9-9-dimethyl-4-5-bis-di-tert-butylphosphino-xanthene-photophysical-properties-and-structural-rigidity-under-pressure
#9
Sarah Keller, Alessandro Prescimone, Edwin C Constable, Catherine E Housecroft
The heteroleptic complexes [Cu(tBu-xantphos)(bpy)][PF6 ] and [Ag(tBu-xantphos)(bpy)][PF6 ], where tBu-xantphos = 9,9-dimethyl-4,5-bis(di-tert-butylphosphino)xanthene and bpy = 2,2'-bipyridine have been synthesized and their photophysical properties investigated. Single crystal X-ray diffraction studies of the compounds under ambient and increased pressure are presented; increase in pressure results in little structural perturbation. For the copper(i) complexes, the effects of changing the N^N ligand from bpy to 6-methyl-2,2'-bipyridine (6-Mebpy), 6-bromo-2,2'-bipyridine (6-Brbpy), and 4,4'-di(tert-butyl)-2,2'-bipyridine (4,4'-tBu2 bpy) were also investigated...
February 19, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29457449/catalytically-active-single-chain-polymeric-nanoparticles-exploring-their-functions-in-complex-biological-media
#10
Yiliu Liu, Silvia Pujals, Patrick J M Stals, Thomas Pauloehrl, Stanislav I Presolski, E W Meijer, Lorenzo Albertazzi, Anja R A Palmans
Dynamic single-chain polymeric nanoparticles (SCPNs) are intriguing, bioinspired architectures that result from the collapse or folding of an individual polymer chain into a nanometer-sized particle. Here we present a detailed biophysical study on the behavior of dynamic SCPNs in living cells and an evaluation of their catalytic functionality in such a complex medium. We first developed a number of delivery strategies that allowed the selective localization of SCPNs in different cellular compartments. Live/dead tests showed that the SCPNs were not toxic to cells while spectral imaging revealed that SCPNs provide a structural shielding and reduced the influence from the outer biological media...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29457253/power-transformations-improve-interpolation-of-grids-for-molecular-mechanics-interaction-energies
#11
David D L Minh
A common strategy for speeding up molecular docking calculations is to precompute nonbonded interaction energies between a receptor molecule and a set of three-dimensional grids. The grids are then interpolated to compute energies for ligand atoms in many different binding poses. Here, I evaluate a smoothing strategy of taking a power transformation of grid point energies and inverse transformation of the result from trilinear interpolation. For molecular docking poses from 85 protein-ligand complexes, this smoothing procedure leads to significant accuracy improvements, including an approximately twofold reduction in the root mean square error at a grid spacing of 0...
February 18, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29456541/ifn-%C3%AF-mediated-control-of-bovine-major-histocompatibility-complex-class-i-expression-and-function-via-the-regulation-of-bta-mir-148b-152-in-bovine-endometrial-epithelial-cells
#12
Haichong Wu, Kangfeng Jiang, Shuai Guo, Jing Yang, Gan Zhao, Changwei Qiu, Ganzhen Deng
IFN-τ, a type I interferon produced by the trophoblasts of ruminants, has various important immune functions, including effects on the expression of major histocompatibility complex (MHC) class I (MHC-I). A previous study has reported that IFN-τ promotes the expression of MHC-I molecules on endometrial cells. However, the immunological mechanisms by which IFN-τ regulates MHC-I molecules remain unknown. Here, we investigated which microRNA (miRNAs) may be involved in the regulation of MHC-I molecule expression and function in bovine endometrial epithelial cells (bEECs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29456440/maltreated-children-use-more-grammatical-negations
#13
Franziska Knolle, Claire D Vallotton, Catherine C Ayoub
Many studies reveal a strong impact of childhood maltreatment on language development, mainly resulting in shorter utterances, less rich vocabulary, or a delay in grammatical complexity. However, different theories suggest the possibility for resilience-a positive adaptation to an otherwise adverse environment-in children who experienced childhood maltreatment. Here, we investigated different measures for language development in spontaneous speech, examining whether childhood maltreatment leads to a language deficit only or whether it can also result in differences in language use due to a possible adaptation to a toxic environment...
2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29456397/periodontal-flap-surgery-along-with-vestibular-deepening-with-diode-laser-to-increase-attached-gingiva-in-lower-anterior-teeth-a-prospective-clinical-study
#14
Ashu Bhardwaj, Zeba Jafri, Nishat Sultan, Madhuri Sawai, Anika Daing
Background: Chronic periodontitis in lower anterior teeth results in rapidly progressive gingival recession (GR), loss of alveolar bone, decreased vestibular depth (VD) with consequential tooth mobility, and tooth loss. Treatment option for such cases in this esthetically important area of the oral cavity includes extraction followed by implants for which sufficient bone height and mucogingival complex are a prerequisite. Henceforth, an attempt was made to prolong the life of lower anterior teeth and postpone the need for implants by the treatment of chronic periodontitis with periodontal flap surgery followed by vestibular deepening in single surgical procedure...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456261/insights-into-activation-of-cobalt-pre-catalysts-for-c-sp-2-h-functionalization
#15
Jennifer V Obligacion, Hongyu Zhong, Paul J Chirik
The activation of readily prepared, air-stable cobalt (II) bis(carboxylate) pre-catalysts for the functionalization of C( sp 2 )-H bonds has been systematically studied. With the pyridine bis(phosphine) chelate,iPr PNP, treatment of 1-(O2 Ct Bu)2 with either B2 Pin2 or HBPin generated cobalt boryl products. With the former, reduction to (iPr PNP)CoI BPin was observed while with the latter, oxidation to the cobalt(III) dihydride boryl, trans -(iPr PNP)Co(H)2 BPin occurred. The catalytically inactive cobalt complex, Co[PinB(O2 Ct Bu)2 ]2, accompanied formation of the cobalt-boryl products in both cases...
November 2017: Israel Journal of Chemistry
https://www.readbyqxmd.com/read/29456224/alport-s-syndrome-with-focal-segmental-glomerulosclerosis-lesion-pattern-to-recognize
#16
Afnan A Alsahli, Sara I Alshahwan, Amal O Alotaibi, Khaled O Alsaad, Nourah Aloudah, Mahfooz Farooqui, Abdullah A Al Sayyari
The association between Alport's syndrome (AS) and focal segmental glomerulosclerosis (FSGS) in the same patient is complex and rarely reported. We report a case of a 42-year-old male presenting with proteinuria, microscopic hematuria, elevated serum creatinine and hypertension with unremarkable physical examination apart from obesity. The renal biopsy showed well-established FSGS pattern of injury with mild interstitial fibrosis and tubular atrophy, while the electron microscopic examination demonstrated glomerular basement membranes (GBM) changes compatible with AS...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455427/variation-in-cardiac-markers-and-electrocardiographic-alterations-in-young-calves-naturally-infected-with-bovine-tropical-theileriosis
#17
Kapil Kumar Gupta, Mukesh Srivastava, Vikrant Sudan, Shanker Kumar Singh, Soumen Choudhury, Daya Shanker
The present study was designed to assess the deleterious effects of bovine tropical theileriosis on the cardiovascular system and the consequent myocardial involvement in young calves. Myocardial effects in parasitic diseases are often neglected. Hemolytic anemia, associated secondary hypoxia, and vasculitis are cardinal features of bovine theileriosis. In the present study, electrocardiogram (ECG) alongside serum cardiac troponin I (cTnI) and creatinine phosphokinase-myocardial band (CPK-MB) concentrations were analyzed in infected, treated, and control groups of young calves...
February 17, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29455088/parasite-susceptibility-in-an-amphibian-host-is-modified-by-salinization-and-predators
#18
Nicholas Buss, Jessica Hua
Secondary salinization represents a global threat to freshwater ecosystems. Salts, such as NaCl, can be toxic to freshwater organisms and may also modify the outcome of species interactions (e.g. host-parasite interactions). In nature, hosts and their parasites are embedded in complex communities where they face anthropogenic and biotic (i.e. predators) stressors that influence host-parasite interactions. As human populations grow, considering how anthropogenic and natural stressors interact to shape host-parasite interactions will become increasingly important...
February 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29455078/a-supersensitive-silver-nanoprobe-based-aptasensor-for-low-cost-detection-of-malathion-residues-in-water-and-food-samples
#19
Rajni Bala, Sherry Mittal, Rohit K Sharma, Nishima Wangoo
In the present study, we report a highly sensitive, rapid and low cost colorimetric monitoring of malathion (an organophosphate insecticide) employing a basic hexapeptide, malathion specific aptamer (oligonucleotide) and silver nanoparticles (AgNPs) as a nanoprobe. AgNPs are made to interact with the aptamer and peptide to give different optical responses depending upon the presence or absence of malathion. The nanoparticles remain yellow in color in the absence of malathion owing to the binding of aptamer with peptide which otherwise tends to aggregate the particles because of charge based interactions...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454867/acellular-filtrate-of-a-microbial-based-cleaning-product-potentiates-house-dust-mite-allergic-lung-inflammation
#20
Azam F Tayabali, Yan Zhang, Jason H Fine, Don Caldwell, Martha Navarro
Microbial-based cleaning products (MBCPs) contain bacteria and chemical constituents. They are used in consumer applications such as odour reduction, unclogging drains, and surface cleaning. To determine the capacity of a model MBCP to contribute to acute allergic lung inflammation, a two-week repeated exposure regimen was used. Mice were exposed by endotracheal instillation to saline alone, MBCP alone, house dust mites (HDM) alone, or sequentially (i.e., MBCP followed by HDM, HDM followed by MBCP, or HDM + MBCP followed by HDM)...
February 15, 2018: Food and Chemical Toxicology
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