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https://www.readbyqxmd.com/read/29031187/modelling-transitions-in-urban-water-systems
#1
W Rauch, C Urich, P M Bach, B C Rogers, F J de Haan, R R Brown, M Mair, D T McCarthy, M Kleidorfer, R Sitzenfrei, A Deletic
Long term planning of urban water infrastructure requires acknowledgement that transitions in the water system are driven by changes in the urban environment, as well as societal dynamics. Inherent to the complexity of these underlying processes is that the dynamics of a system's evolution cannot be explained by linear cause-effect relationships and cannot be predicted under narrow sets of assumptions. Planning therefore needs to consider the functional behaviour and performance of integrated flexible infrastructure systems under a wide range of future conditions...
September 22, 2017: Water Research
https://www.readbyqxmd.com/read/29031069/synthesis-and-biological-evaluation-of-a-platinum-ii-c-rgdyk-conjugate-for-integrin-targeted-photodynamic-therapy
#2
T Chatzisideri, S Thysiadis, S Katsamakas, P Dalezis, I Sigala, T Lazarides, E Nikolakaki, D Trafalis, O A Gederaas, M Lindgren, V Sarli
A cancer-targeting conjugate 4 of a cyclometalated [N,C,N-Pt(II)] complex bearing a NˆCˆN 1,3-di(2-pyridyl)-benzene with c(RGDyK) peptide as guiding molecule was designed and synthesized for real-time drug delivery monitoring in cancer cells and photodynamic therapy (PDT). This conjugate demonstrates a mild cytostatic effect to six cancer cell lines expressing integrins at different extent, while possessing promising features for PDT. Conjugate 4 demonstrated rapid cell uptake by receptor-mediated endocytosis and efficient generation of (1)O2 upon irradiation...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029371/structures-of-a-complex-hydrazinium-lead-iodide-n2h5-15pb3i21-possessing-pb2i9-5-pbi6-4-and-i-ions-and-%C3%AE-and-%C3%AE-n2h5-pbi3
#3
Joel S Miller, Eric Campbell, Brandon Dick, Arnold Rheingold, Chuang Zhang, Xiaojie Liu, Zeev Vardeny
Photovoltaic Perovskites, most notably methylammonium lead triiodide, (NH3Me)PbI3, have recently attracted considerable attention, and based upon the 'Goldschmidt Tolerance Factor' hydrazinium should be able to occupy the same cation site as methylammonium. The reaction of N2H5+I- with PbI2 in DMF results in three types of yellow crystals; hexagonal, needle-like, and rod-like, whose structures were determined at 100 K. The hexagonal [P63/m: a = 10.8906(10) Å; b = 37.845(5) Å] crystals possess isolated face sharing octahedral [Pb2I9]5-, [PbI6]4-, and I- ions...
October 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29029216/diversity-and-distribution-of-cryptic-species-of-the-bemisia-tabaci-hemiptera-aleyrodidae-complex-in-pakistan
#4
Mariyam Masood, Imran Amin, Ishtiaq Hassan, Shahid Mansoor, Judith K Brown, Rob W Briddon
Bemisia tabaci (Gennadius; Hempitera: Aleyrodidae) is considered to be a cryptic (sibling) species complex, the members of which exhibit morphological invariability while being genetically and behaviorally distinct. Members of the complex are agricultural pests that cause direct damage by feeding on plants, and indirectly by transmitting viruses that cause diseases leading to reduced crop yield and quality. In Pakistan, cotton leaf curl disease, caused by multiple begomovirus species, is the most economically important viral disease of cotton...
October 4, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29028943/a-joint-model-for-mixed-and-truncated-longitudinal-data-and-survival-data-with-application-to-hiv-vaccine-studies
#5
Tingting Yu, Lang Wu, Peter B Gilbert
In HIV vaccine studies, a major research objective is to identify immune response biomarkers measured longitudinally that may be associated with risk of HIV infection. This objective can be assessed via joint modeling of longitudinal and survival data. Joint models for HIV vaccine data are complicated by the following issues: (i) left truncations of some longitudinal data due to lower limits of quantification; (ii) mixed types of longitudinal variables; (iii) measurement errors and missing values in longitudinal measurements; (iv) computational challenges associated with likelihood inference...
September 23, 2017: Biostatistics
https://www.readbyqxmd.com/read/29028891/on-the-mechanisms-of-protein-interactions-predicting-their-affinity-from-unbound-tertiary-structures
#6
Manuel Alejandro Marín-López, Joan Planas-Iglesias, Joaquim Aguirre-Plans, Jaume Bonet, Javier Garcia-Garcia, Narcis Fernandez-Fuentes, Baldo Oliva
Motivation: The characterization of the protein-protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters enhances the realization of the stereospecific (i.e. native) complex by reducing the dimensionality of the search process. The association rate for the formation of such complex plays a crucial role in the cell biology and depends on how the partners diffuse to be close to each other...
September 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028836/affected-pathways-and-transcriptional-regulators-in-gene-expression-response-to-an-ultra-marathon-trail-global-and-independent-activity-approaches
#7
Maria Maqueda, Emma Roca, Daniel Brotons, Jose Manuel Soria, Alexandre Perera
Gene expression (GE) analyses on blood samples from marathon and half-marathon runners have reported significant impacts on the immune and inflammatory systems. An ultra-marathon trail (UMT) represents a greater effort due to its more testing conditions. For the first time, we report the genome-wide GE profiling in a group of 16 runners participating in an 82 km UMT competition. We quantified their differential GE profile before and after the race using HuGene2.0st microarrays (Affymetrix Inc., California, US)...
2017: PloS One
https://www.readbyqxmd.com/read/29028817/mitochondrial-dysfunction-in-the-gastrointestinal-mucosa-of-children-with-autism-a-blinded-case-control-study
#8
Shannon Rose, Sirish C Bennuri, Katherine F Murray, Timothy Buie, Harland Winter, Richard Eugene Frye
Gastrointestinal (GI) symptoms are prevalent in autism spectrum disorder (ASD) but the pathophysiology is poorly understood. Imbalances in the enteric microbiome have been associated with ASD and can cause GI dysfunction potentially through disruption of mitochondrial function as microbiome metabolites modulate mitochondrial function and mitochondrial dysfunction is highly associated with GI symptoms. In this study, we compared mitochondrial function in rectal and cecum biopsies under the assumption that certain microbiome metabolites, such as butyrate and propionic acid, are more abundant in the cecum as compared to the rectum...
2017: PloS One
https://www.readbyqxmd.com/read/29028758/mr-neurography-of-lumbosacral-plexus-in-failed-back-surgery-syndrome
#9
Riham Dessouky, Mohammed Khaleel, Dalia N Khalifa, Hazim I Tantawy, Avneesh Chhabra
STUDY DESIGN: Retrospective clinical case series. OBJECTIVE: To study the role of MRN of lumbosacral plexus in management of patients with FBSS. SUMMARY OF BACKGROUND DATA: Failed back surgery syndrome (FBSS) is one of the major problems in health care, affecting up to 40% of patients following spine surgery. To date, no imaging modality has been used to effectively classify nerve compression, since nerve injuries are challenging to detect on conventional lumbar spine MRI...
October 12, 2017: Spine
https://www.readbyqxmd.com/read/29028576/bioelectrochromic-hydrogel-for-fast-antibiotic-susceptibility-testing
#10
Ferran Pujol-Vila, Jiri Dietvorst, Laura Gall-Mas, María Díaz-González, Núria Vigués, Jordi Mas, Xavier Muñoz-Berbel
Materials science offers new perspectives in the clinical analysis of antimicrobial sensitivity. However, a biomaterial with the capacity to respond to living bacteria has not been developed to date. We present an electrochromic iron(III)-complexed alginate hydrogel sensitive to bacterial metabolism, here applied to fast antibiotic-susceptibility determination. Bacteria under evaluation are entrapped -and pre-concentrated- in the hydrogel matrix by oxidation of iron (II) ions to iron (III) and in situ formation of the alginate hydrogel in less than 2min and in soft experimental conditions (i...
September 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028558/determinants-of-trust-in-the-flu-vaccine-for-african-americans-and-whites
#11
Vicki S Freimuth, Amelia M Jamison, Ji An, Gregory R Hancock, Sandra Crouse Quinn
Trust is thought to be a major factor in vaccine decisions, but few studies have empirically tested the role of trust in adult immunization. Utilizing a 2015 national survey of African American and White adults (n = 1630), we explore multiple dimensions of trust related to influenza immunization, including generalized trust, trust in the flu vaccine, and trust in the vaccine production process. We find African Americans report lower trust than Whites across all trust measures. When considering demographic, racial, and ideological predictors, generalized trust shows statistically significant effects on both trust in the flu vaccine and trust in the vaccine process...
October 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29028397/detection-of-gas-traces-using-semiconductor-sensors-ion-mobility-spectrometry-and-mass-spectrometry
#12
Yulia R Shaltaeva, Boris I Podlepetsky, Vyacheslav S Pershenkov
This article deals with the state-of-the-art instrumentation and application in the field of solid state gas sensorics, ion mobility spectrometry and mass-spectrometry-related research for the detection and measurements of low gas and vapor concentrations. The advantages and disadvantages of gas-analytical devices and systems are discussed, as well as the possibilities of its complex and/or complementary applications. Ion mobility spectrometry-mass spectrometry and subsequent techniques based on solid-state gas sensors are proposed for planned medical study...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028330/ambient-stable-bis-azoaromatic-centered-diradical-l-%C3%A2-m-l-%C3%A2-complexes-of-rh-iii-synthesis-structure-redox-and-spin-spin-interaction
#13
Sima Roy, Shuvam Pramanik, Sarat Chandra Patra, Basab Adhikari, Abhishake Mondal, Sanjib Ganguly, Kausikisankar Pramanik
Bis-azoaromatic electron traps, viz. 2-(2-pyridylazo)azoarene 1, have been synthesized by colligating electron-deficient pyridine and azoarene moieties, and they act as apposite proradical templates for the formation of stable open-shell diradical complexes [(1(•-))Rh(III)(1(•-))](+) ([2](+)), starting from the low-valent electron reservoir [Rh(I)]. The less stable monoradical [Rh(III)(1(•-))Cl2(PPh3)3] (3) has also been isolated as a minor product. These π-radical complexes are multiredox systems, and the electron transfer processes occur exclusively within the pincer-type NNN ligand backbone 1...
October 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29028016/measuring-the-electromagnetic-chirality-of-2d-arrays-under-normal-illumination
#14
X Garcia-Santiago, S Burger, C Rockstuhl, I Fernandez-Corbaton
We present an electromagnetic chirality measure for 2D arrays of subwavelength periodicities under normal illumination. The calculation of the measure uses only the complex reflection and transmission coefficients from the array. The measure allows the ordering of arrays according to their electromagnetic chirality, which further allows a quantitative comparison of different design strategies. The measure is upper bounded, and the extreme properties of objects with high values of electromagnetic chirality make them useful in both near- and far-field applications...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29027943/low-grade-dysplastic-nodules-revealed-as-the-tipping-point-during-multistep-hepatocarcinogenesis-by-dynamic-network-biomarkers
#15
Lina Lu, Zhonglin Jiang, Yulin Dai, Luonan Chen
Hepatocellular carcinoma (HCC) is a complex disease with a multi-step carcinogenic process from preneoplastic lesions, including cirrhosis, low-grade dysplastic nodules (LGDNs), and high-grade dysplastic nodules (HGDNs) to HCC. There is only an elemental understanding of its molecular pathogenesis, for which a key problem is to identify when and how the critical transition happens during the HCC initiation period at a molecular level. In this work, for the first time, we revealed that LGDNs is the tipping point (i...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29027735/temporal-trends-in-percutaneous-coronary-interventions-thru-the-drug-eluting-stent-era-insights-from-18-641-procedures-performed-over-12-year-period
#16
Uri Landes, Tamir Bental, Amos Levi, Abid Assali, Hana Vaknin-Assa, Eli I Lev, Eldad Rechavia, Gabriel Greenberg, Katia Orvin, Ran Kornowski
BACKGROUND: The last decade, regarded as the DES era in PCI, has witnessed significant advances in the management of coronary disease. We aimed to assess temporal trends in the practice and outcome of percutaneous coronary intervention (PCI) during the drug eluting stent (DES) era. METHODS: We analyzed 18,641 consecutive PCI's performed between January 2004 and December 2016, distinguished by procedural date (Q1 : 2004-2006, n = 4,865; Q2 : 2007-2009, n = 4,977; Q3 : 2010-2012, n = 4,230; Q4 : 2013-2016, n = 4,569)...
October 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29027494/discriminating-non-native-segmental-length-contrasts-under-increased-task-demands
#17
Yuki Asano
The present study examines how vulnerable perception of second language prosody is to increased task demands. German learners of Japanese, German non-learners without exposure to Japanese, and Japanese native listeners were tested in their ability to discriminate consonant length contrasts (compared to vowel length contrasts that served as a control condition). Memory load was increased by a longer inter-stimulus interval (2500 ms compared to 300 ms) and the demand on attention control was enhanced through the addition of the acoustic complexity of the stimuli (i...
October 1, 2017: Language and Speech
https://www.readbyqxmd.com/read/29027362/impact-of-extraction-methods-on-the-detectable-protein-complement-of-metaproteomic-analyses-of-marine-sediments
#18
Lars Wöhlbrand, Christoph Feenders, Jessica Nachbaur, Holger Freund, Bert Engelen, Heinz Wilkes, Hans-Jürgen Brumsack, Ralf Rabus
Metaproteomic analysis targets proteins, the catalytic entities in the habitat, thereby providing direct insights into the metabolic activity of the community studied. A major challenge still remaining for metaproteomics is the effective and comprehensive extraction of proteins from environmental samples, due to their high complexity with respect to organismic diversity and abundance range. Moreover, in certain habitats, the inherent matrix may interfere with protein extraction. In recent years, several studies reported different protein extraction methods for soils known for their complex geochemistry, but only two analyzed marine sediments that generally comprise different though similarly complex geochemistry...
October 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29027277/relativistic-dft-calculations-of-hyperfine-coupling-constants-in-the-5d-hexafluorido-complexes-ref6-2-and-irf6-2
#19
Pi A B Haase, Michal Repisky, Stanislav Komorovsky, Jesper Bendix, Stephan P A Sauer
The performance of relativistic density functional theory (DFT) methods has been investigated for the calculation of the recently measured hyperfine coupling constants of Re IV and Ir IV in their hexafluorido ions, [ReF6]2- and [IrF6]2-. Three relativistic methods have been employed at the DFT level of theory: the 2-component zeroth order regular approximation (ZORA) method treating the spin-orbit coupling either variationally (EV ZORA) or as a perturbation (LR ZORA) and the 4-component Dirac-Kohn-Sham (DKS) method...
October 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29027230/immunogenic-stress-and-death-of-cancer-cells-contribution-of-antigenicity-vs-adjuvanticity-to-immunosurveillance
#20
REVIEW
Norma Bloy, Pauline Garcia, Céline M Laumont, Jonathan M Pitt, Antonella Sistigu, Gautier Stoll, Takahiro Yamazaki, Eric Bonneil, Aitziber Buqué, Juliette Humeau, Jan W Drijfhout, Guillaume Meurice, Steffen Walter, Jens Fritsche, Toni Weinschenk, Hans-Georg Rammensee, Cornelis Melief, Pierre Thibault, Claude Perreault, Jonathan Pol, Laurence Zitvogel, Laura Senovilla, Guido Kroemer
Cancer cells are subjected to constant selection by the immune system, meaning that tumors that become clinically manifest have managed to subvert or hide from immunosurveillance. Immune control can be facilitated by induction of autophagy, as well as by polyploidization of cancer cells. While autophagy causes the release of ATP, a chemotactic signal for myeloid cells, polyploidization can trigger endoplasmic reticulum stress with consequent exposure of the "eat-me" signal calreticulin on the cell surface, thereby facilitating the transfer of tumor antigens into dendritic cells...
November 2017: Immunological Reviews
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