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https://www.readbyqxmd.com/read/29761336/-syncope-in-children-and-adolescents
#1
REVIEW
Matthias J Müller, Thomas Paul
Syncope is common in children and adolescents. Neurally mediated syncope including pallid and cyanotic breath holding spells, vagovasal syncope and neurocardiogenic syncope is based on a common pathomechanism and accounts for approximately 75% of cases. A potentially life-threatening cardiac cause of syncope may be present in up to 6%. Detailed history, physical examination and 12-lead electrocardiogram (ECG) allow discrimination between benign and serious syncope in the majority of pediatric patients. Tilt-testing can be useful when diagnosis is unclear...
May 14, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29754204/diagnosing-arvc-in-pediatric-patients-applying-the-revised-task-force-criteria-importance-of-imaging-12-lead-ecg-and-genetics
#2
Michael Steinmetz, Ulrich Krause, Peter Lauerer, Frank Konietschke, Randolph Aguayo, Christian Oliver Ritter, Andreas Schuster, Joachim Lotz, Thomas Paul, Wieland Staab
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a potentially lethal disease that is well described in adults. In pediatric patients, however, identification of patients at risk of adverse events of ARVC remains a challenge. We aimed to determine which criteria of the revised Task Force Criteria (rTFC), alone or combined, have an impact on diagnosis of ARVC when compared to disease-specific genetic mutations in pediatric patients ≤ 18 years. Between September 2010 and December 2013, 48 consecutive young patients ≤ 18 years of age (mean 14, range of 12...
May 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29688314/electrocardiographic-characteristics-anthropometric-features-and-cardiovascular-risk-factors-in-a-large-cohort-of-adolescents
#3
Massimo Santini, Stefania Angela Di Fusco, Furio Colivicchi, Alessio Gargaro
Aims: The characteristics of electrocardiographic (ECG) patterns in the general population of adolescents are insufficiently defined. The purpose of this study is to report ECG patterns and their association with anthropometric characteristics. Methods and results: Twenty-four thousand and sixty-two students of Roman schools, aged 12-19, were screened with ECG and physical examinations. Electrocardiographic abnormalities were classified as either minor/non-clinically relevant or major, and anthropometric measures were evaluated per age class...
April 23, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29681953/omega-3-fatty-acid-supplementation-improves-heart-rate-variability-in-obese-children
#4
Christoph Baumann, Ulla Rakowski, Reiner Buchhorn
Obese children and adolescents are at high risk of developing cardiovascular diseases later in life. We hypothesized that cardiovascular prophylaxis with omega-3 fatty acids could benefit them. In our study, 20 children and adolescents (mean body mass index percentile: 99.1; mean age: 11.0 years) underwent two ambulatory 24 h Holter electrocardiography (ECG) recordings (before and after at least 3 months of omega-3 fatty acid supplementation). Time domain heart rate variability (HRV) and heart rate (HR) were examined for these patients...
2018: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29651961/the-benefit-of-prescribing-vitamin-d-as-add-on-therapy-on-the-electrocardiographic-changes-in-epileptic-patients
#5
Marwan S M Al-Nimer
BACKGROUND: Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events. OBJECTIVE: This study aimed to show that epileptic patients who treated with antiepileptic drugs supplemented with vitamin D are free from the electrocardiograph changes compared with those treated with antiepileptic drugs. METHOD: This cross-sectional study included, 121 epileptic patients aged < 18 years of both genders with a history of idiopathic generalized tonic clonic seizure...
April 12, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29643156/indecho-study-cohort-study-investigating-birth-size-childhood-growth-and-young-adult-cardiovascular-risk-factors-as-predictors-of-midlife-myocardial-structure-and-function-in-south-asians
#6
Senthil K Vasan, Ambuj Roy, Viji Thomson Samuel, Belavendra Antonisamy, Santosh K Bhargava, Anoop George Alex, Bhaskar Singh, Clive Osmond, Finney S Geethanjali, Fredrik Karpe, Harshpal Sachdev, Kanhaiya Agrawal, Lakshmy Ramakrishnan, Nikhil Tandon, Nihal Thomas, Prasanna S Premkumar, Prrathepa Asaithambi, Sneha F X Princy, Sikha Sinha, Thomas Vizhalil Paul, Dorairaj Prabhakaran, Caroline H D Fall
INTRODUCTION: South Asians have high rates of cardiovascular disease (CVD) and its risk factors (hypertension, diabetes, dyslipidaemia and central obesity). Left ventricular (LV) hypertrophy and dysfunction are features of these disorders and important predictors of CVD mortality. Lower birth and infant weight and greater childhood weight gain are associated with increased adult CVD mortality, but there are few data on their relationship to LV function. The IndEcho study will examine associations of birth size, growth during infancy, childhood and adolescence and CVD risk factors in young adulthood with midlife cardiac structure and function in South Asian Indians...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29570943/the-relationship-between-heart-rate-variability-psychological-flexibility-and-pain-in-neurofibromatosis-type-1
#7
Taryn M Allen, Kari L Struemph, Mary Anne Toledo-Tamula, Pamela L Wolters, Andrea Baldwin, Brigitte Widemann, Staci Martin
Individuals with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PNs) can experience chronic pain. Previous research has examined the relationship between heart rate variability (HRV) and persistent pain. HRV is an index of autonomic nervous system functioning, and reflects the variability in time elapsed between heartbeats. Patients with chronic pain tend to exhibit lower HRV, which has been associated with poor adaptability, or psychological flexibility, to stress. The aim of the current study was to examine relationships between HRV, psychological flexibility and pain in a sample of adolescents and young adults (AYA) with NF1 and PNs...
March 23, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29556784/study-on-ecg-in-the-adolescent
#8
Hung-Chi Lue, Mei-Hwan Wu, Jou-Kou Wang, Min-Tai Lin, Chun-Wei Lu, Shuenn-Nan Chiu, Chun-An Chen, En-Ting Wu, Ching-Chia Wang, Chun-Min Fu, Wei-Chien Tseng, Wei-Hsuan Chang, Meng-Chang Lee
Normal ECG values in newborns, infants, and children have been collected and published. ECG in the adolescent, however, remains, to be collected and studied. The present study was designed and carried out to establish the normal ECG standards in male and female adolescents. A total of 898 school children and adolescents screened and examined as healthy were divided by age and sex into 6-9, 9-13, and 13-18 years age-groups. A 12 lead conventional ECG was recorded in 10 mm/mV and 25 mm/s, utilizing an automated Fukuda Denshi FCP-4301, MS-DOS/IBM-AT ECG machine...
June 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29538783/pediatric-electrocardiograms-for-the-general-practitioner-the-importance-of-the-t-wave
#9
Gul H Dadlani, Thomas C Edwards, Steven Fishberger, Amos Epelman, Nicholas Erbrich
Electrocardiograms may be used to screen for cardiovascular disease (CVD) in children. Many forms of CVD that predispose to sudden cardiac death are associated with T-wave abnormalities in childhood. The T-wave is generated during ventricular repolarization. T-waves on an electrocardiogram typically undergo maturational changes throughout childhood and adolescence. A pediatric practitioner's ability to understand these changes is required to understand abnormal T-waves and recognize potentially life-threatening types of CVD...
March 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29487127/maternal-immune-activation-during-the-third-trimester-is-associated-with-neonatal-functional-connectivity-of-the-salience-network-and-fetal-to-toddler-behavior
#10
Marisa N Spann, Catherine Monk, Dustin Scheinost, Bradley S Peterson
Prenatal maternal immune activation (MIA) is associated with altered brain development and risk of psychiatric disorders in offspring. Translational human studies of MIA are few in number. Alterations of the salience network have been implicated in the pathogenesis of the same psychiatric disorders associated with MIA. If MIA is pathogenic, then associated abnormalities in the salience network should be detectable in neonates immediately after birth. We tested the hypothesis that third trimester MIA of adolescent women who are at risk for high stress and inflammation is associated with the strength of functional connectivity in the salience network of their neonate...
March 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29332211/testosterone-mediated-upregulation-of-delayed-rectifier-potassium-channel-in-cardiomyocytes-causes-abbreviation-of-qt-intervals-in-rats
#11
Kimiko Masuda, Hiroki Takanari, Masaki Morishima, FangFang Ma, Yan Wang, Naohiko Takahashi, Katsushige Ono
Men have shorter rate-corrected QT intervals (QTc) than women, especially at the period of adolescence or later. The aim of this study was to elucidate the long-term effects of testosterone on cardiac excitability parameters including electrocardiogram (ECG) and potassium channel current. Testosterone shortened QT intervals in ECG in castrated male rats, not immediately after, but on day 2 or later. Expression of Kv7.1 (KCNQ1) mRNA was significantly upregulated by testosterone in cardiomyocytes of male and female rats...
January 13, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29325638/implantable-cardioverter-defibrillators-in-children-and-adolescents-with-brugada-syndrome
#12
M Cecilia Gonzalez Corcia, Juan Sieira, Gudrun Pappaert, Carlo de Asmundis, Gian Battista Chierchia, Mark La Meir, Andrea Sarkozy, Pedro Brugada
BACKGROUND: Young patients presenting with symptomatic Brugada syndrome have very high risks for ventricular arrhythmias and should be carefully considered for implantable cardioverter-defibrillator (ICD) placement. However, this therapy is associated with high rates of inappropriate shocks and device-related complications. OBJECTIVES: This study investigated clinical features, management, and long-term follow-up of young patients with Brugada syndrome and ICD. METHODS: Patients diagnosed with Brugada syndrome, who underwent implantation of an ICD at an age of ≤20 years, were studied...
January 16, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29262473/-clinical-challenges-in-the-management-of-catecholaminergic-polymorphic-ventricular-tachycardia-in-children
#13
H Y Ge, X M Li, H Jiang, Y Zhang, H J Liu, X C Zheng, M T Li
Objective: Catecholaminergic polymorphic ventricular tachycardia (CPVT) accounts for up to 10%-15% sudden cardiac death (SCD) in the children and young population. This study aimed to assess the current situation and challenges in CPVT clinical diagnosis. Method: A retrospective review included 11 children (7 male patients) at the First Hospital of Tsinghua University clinically diagnosed with CPVT from June 2014 to July 2017. Each patient was evaluated with detailed history, physical examination, resting 12-lead electrocardiogram(ECG), 24-h Holter, exercise stress test, Doppler echocardiography and genetic test...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29240719/pericardial-effusion-as-a-presenting-symptom-of-hashimoto-thyroiditis-a-case-report
#14
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Hashimoto thyroiditis (HT) is the most frequent cause of acquired hypothyroidism in paediatrics. HT is usually diagnosed in older children and adolescents, mainly in females and is rare in infants and toddlers with cardiac involvement, including pericardial effusion, that can be found in 10% to 30% of adult HT cases. In this paper, a child with HT and pericardial effusion as the most important sign of HT is described. Case presentation : A four-year-old male child suffering for a few months from recurrent abdominal pain sometimes associated with vomiting underwent an abdominal ultrasound scan outside the hospital...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29199265/standard-values-and-characteristics-of-electrocardiographic-findings-in-children-and-adolescents
#15
Masao Yoshinaga, Mari Iwamoto, Hitoshi Horigome, Naokata Sumitomo, Hiroya Ushinohama, Naomi Izumida, Nobuo Tauchi, Tatsuya Yoneyama, Katsumi Abe, Masami Nagashima
BACKGROUND: Reference values and the characteristics of the electrocardiographic (ECG) findings using a large number of subjects are lacking for children and adolescents.Methods and Results:A total of 56,753 digitally stored ECGs of participants in a school-based ECG screening system were obtained between 2006 and 2009 in Kagoshima, Japan. Each ECG was manually reviewed by 2 pediatric cardiologists and only ECGs with sinus rhythm were included. A final total of 48,401 ECGs from 16,773 1st (6 years old, 50% girls), 18,126 7th (12 years old, 51% girls), and 13,502 10th graders (15 years old, 52% girls) were selected...
February 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29191613/abnormal-biventricular-performance-in-asymptomatic-adolescents-late-after-repaired-tetralogy-of-fallot-combined-two-dimensional-speckle-tracking-and-three-dimensional-echocardiography-study
#16
Ken-Pen Weng, Yu-Chi Hung, Shih-Hui Huang, Huang-Wei Wu, Kuang-Jen Chien, Chu-Chuan Lin, Hsu-Hsia Peng, Ming-Ting Wu
BACKGROUND: The aim of this prospective study was to assess biventricular performance in asymptomatic adolescents with repaired tetralogy of Fallot (TOF) using 2D speckle tracking and real time 3D echocardiography simultaneously. METHODS: We studied 31 patients with repaired TOF (M/F: 22/9, age: 16.1 ± 6.1 yrs) who had history of cardiac surgery with mean follow-up duration of 12.8 years, and 32 age- and sex-matched normal individuals (M/F: 23/9, age: 16.6 ± 5...
February 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29189044/desvenlafaxine-versus-placebo-in-a-fluoxetine-referenced-study-of-children-and-adolescents-with-major-depressive-disorder
#17
Karen L Weihs, William Murphy, Richat Abbas, Deborah Chiles, Richard D England, Sara Ramaker, Dalia B Wajsbrot
OBJECTIVES: To evaluate the short-term efficacy and safety of desvenlafaxine (25-50 mg/d) compared with placebo in children and adolescents with major depressive disorder (MDD). METHODS: Outpatient children (7-11 years) and adolescents (12-17 years) who met DSM-IV-TR criteria for MDD and had screening and baseline Children's Depression Rating Scale-Revised (CDRS-R) total scores >40 were randomly assigned to 8-week treatment with placebo, desvenlafaxine (25, 35, or 50 mg/d based on baseline weight), or fluoxetine (20 mg/d)...
February 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29185022/change-and-dispersion-of-qt-interval-during-treatment-with-quetiapine-extended-release-versus-aripiprazole-in-children-and-adolescents-with-first-episode-psychosis-results-from-the-tea-trial
#18
Karsten Gjessing Jensen, Stefan Gärtner, Christoph U Correll, Ditte Rudå, Dea Gowers Klauber, Marie Stentebjerg-Olesen, Birgitte Fagerlund, Jens Richardt Jepsen, Anders Fink-Jensen, Klaus Juul, Anne Katrine Pagsberg
OBJECTIVE: The aim of this study was to compare the effect of quetiapine extended release (ER) versus aripiprazole on corrected QT interval (QTc) and QT dispersion (QTd) in youths with first-episode psychosis. METHODS: Youths 12-17 years were randomized to quetiapine ER (daily dose range = 50 to 800 mg) or aripiprazole (daily dose range = 2.5 to 30 mg) in a 12-week double-blinded trial and examined at weeks 0, 4, and 12. Primary outcome was QTc change using Hodges formula (QTcH); secondary outcomes included QTcH > 450 ms, QTcH > 500 ms, QTcH change > 60 ms, QTd, and heart rate (HR)...
March 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29147785/qt-interval-and-dispersion-in-drug-free-anorexia-nervosa-adolescents-a-case-control-study
#19
Monica Bomba, Lucio Tremolizzo, Fabiola Corbetta, Franco Nicosia, Francesca Lanfranconi, Gianni Poggioli, Karine Goulene, Marco Stramba-Badiale, Elisa Conti, Francesca Neri, Renata Nacinovich
Long QT values have been reported in patients with anorexia nervosa of the restricting type (ANr) potentially increasing the risk of fatal arrhythmia, especially if psychotropic drug treatment is required. Nevertheless, the previous studies on this topic are biased by drug exposure, long disease durations, and small sample sizes. This study is aimed at assessing QTc and QTcd values in ANr adolescents with recent onset and drug free, as compared to subjects affected by psychiatric disorders other than ANr. We evaluated QTc and its dispersion (QTcd) in a population of 77 drug-free ANr female adolescents and compared to an equal number of healthy controls (H-CTRL) and pathological controls (P-CTRL, mixed psychiatric disorders)...
November 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29091143/the-effects-of-cigarette-smoking-on-ventricular-repolarization-in-adolescents
#20
Seyma Kayali, Fadime Demir
OBJECTIVE: To assess the association between cigarette smoking and ventricular arrhythmias in adolescents. Novel electrocardiographic parameters -Tp-e interval, as well as Tpe/QT and Tpe/QTc ratios - were used to make this assessment. METHODS: The study population consisted of 87 subjects aged between 16-19 years. Fifty-one adolescent smokers with no risk of arrhythmia comprised the Smoker Group, and 36 adolescents who had never smoked cigarettes comprised the Control Group...
July 2017: Einstein
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