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https://www.readbyqxmd.com/read/27910804/sudden-cardiac-death-a-nationwide-cohort-study-among-the-young
#1
Bjarke Risgaard
Sudden cardiac death (SCD) is a tragic event affecting millions of individuals worldwide. Although several studies have investigated the epidemiology of SCD, these studies may have been affected by reporting and referral biases, which are reflected in the very different incidence rates and causes of deaths that have previously been reported. Among SCD victims aged < 36 years, inherited cardiac diseases are well known to play an important role. However, the extent to which inherited cardiac diseases also play a role in SCD victims aged < 50 years has not been completely described...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27895451/non-cardiogenic-pulmonary-edema-rhabdomyolysis-and-myocardial-injury-following-heroin-inhalation-a-case-report
#2
G Bazoukis, A Spiliopoulou, K Mourouzis, P Grigoropoulou, A Yalouris
BACKGROUND: Heroin use by non-injecting routes of administration (snorting, swallowing, "chasing the dragon") is considered to be safer but is not risk-free for fatal overdose or serious side effects. We report the case of an adolescent who was transferred unconscious to the emergency department after heroin inhalation. Description of the case: A 17-year-old male was transferred to the emergency department unconscious (Glasgow coma scale: 6/15) after heroin inhalation. He was treated with non-rebreather mask and intravenous infusion of naloxone with gradual improvement of consciousness and arterial blood gasses...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27858403/cardiac-rehabilitation-in-an-adolescent-with-digeorge-syndrome-a-case-report
#3
Dong J Kim, Ka Y Lee, Yuri Choe, Jae Y Han, In S Choi
BACKGROUND: Digeorge syndrome is a rare disease that has variable clinical symptoms resulting from 22q11 deletions, included cardiac abnormality, abnormal face and thymic aplasia, and cognitive impairment. There was a no reports regarding the efficiency of cardiac rehabilitation (CR) in patients with Digeorge syndrome with tetralogy of fallot. CASE REPORT: A 15-year-old girl with DGS visited our CR center. The patient carried out the exercise training 3 times a week for 6 weeks, using a treadmill with electrocardiogram monitoring...
November 18, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27770590/higher-skin-autofluorescence-in-young-people-with-type-1-diabetes-and-microvascular-complications
#4
Y H Cho, M E Craig, A S Januszewski, P Benitez-Aguirre, S Hing, A J Jenkins, K C Donaghue
AIM: To test the hypothesis that non-invasive skin autofluorescence, a measure of advanced glycation end products, would provide a surrogate measure of long-term glycaemia and be associated with early markers of microvascular complications in adolescents with Type 1 diabetes. METHODS: Forearm skin autofluorescence (arbitrary units) was measured in a cross-sectional study of 135 adolescents with Type 1 diabetes [mean ± sd age 15.6 ± 2.1 years, diabetes duration 8...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27708487/the-use-of-continuous-electrocardiographic-holter-monitoring-in-pediatric-cardiology
#5
Zijo Begic, Edin Begic, Senka Mesihovic-Dinarevic, Izet Masic, Senad Pesto, Mirza Halimic, Almira Kadic, Amra Dobraca
OBJECTIVE: To show the place and role of continuous electrocardiographic twenty-four-hour ECG monitoring in daily clinical practice of pediatric cardiologists. METHODS: According to protocol, 2753 patients underwent dynamic continuous ECG Holter monitoring (data collected from the "Register of ECG Holter monitoring" of Pediatric Clinic, UCC Sarajevo in period April 2003- April 2015). RESULTS: There were 50,5% boys and 49,5% girls, aged from birth to 19 years (1,63% - neonates and infants, 2,6% - toddlers, 9,95% - preschool children, 35,5% - gradeschoolers and 50,3% children in puberty and adolescence)...
July 16, 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/27687820/solifenacin-in-children-and-adolescents-with-overactive-bladder-results-of-a-phase-3-randomised-clinical-trial
#6
Donald Newgreen, Brigitte Bosman, Adriana Hollestein-Havelaar, Ellen Dahler, Robin Besuyen, Will Sawyer, Stéphane Bolduc, Søren Rittig
BACKGROUND: Solifenacin, an effective, well-tolerated treatment for adult overactive bladder (OAB) symptoms, has not been evaluated in placebo-controlled paediatric clinical trials. OBJECTIVES: To evaluate the efficacy and safety of once-daily oral solifenacin suspension in OAB patients aged 5-<12 yr (children) and 12-<18 yr (adolescents). DESIGN, SETTING, AND PARTICIPANTS: The study involved a 4-wk urotherapy run-in followed by 1:1 randomisation to 12-wk double-blind solifenacin or placebo treatment alongside urotherapy...
September 28, 2016: European Urology
https://www.readbyqxmd.com/read/27632775/antenatal-steroid-exposure-and-heart-rate-variability-in-adolescents-born-with-very-low-birth-weight
#7
Patricia A Nixon, Lisa K Washburn, Thomas Michael O'Shea, Hossam A Shaltout, Gregory B Russell, Beverly M Snively, James C Rose
BACKGROUND: Reduced heart rate variability (HRV) suggests autonomic imbalance in the control of heart rate and is associated with unfavorable cardiometabolic outcomes. We examined whether antenatal corticosteroid (ANCS) exposure had long-term programming effects on HRV in adolescents born with very low birth weight (VLBW). METHODS: Follow-up study of a cohort of VLBW 14-y olds born between 1992 and 1996 with 50% exposed to ANCS. HRV in both the time and frequency domains using Nevrokard Software was determined from a 5-min electrocardiogram tracing...
October 5, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27614881/heritability-of-heart-rate-recovery-and-vagal-rebound-after-exercise
#8
Ineke Nederend, Nienke M Schutte, Meike Bartels, Arend D J Ten Harkel, Eco J C de Geus
PURPOSE: The prognostic power of heart rate recovery (HRR) after exercise has been well established but the exact origin of individual differences in HRR remains unclear. This study aims to estimate the heritability of HRR and vagal rebound after maximal exercise in adolescents. Furthermore, the role of voluntary regular exercise behavior (EB) in HRR and vagal rebound is tested. METHODS: 491 healthy adolescent twins and their siblings were recruited for maximal exercise testing, followed by a standardized cooldown with measurement of the electrocardiogram and respiratory frequency...
December 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27590665/evolution-of-hypertrophic-cardiomyopathy-in-sarcomere-mutation-carriers
#9
Carolyn Y Ho, Allison L Cirino, Neal K Lakdawala, John Groarke, Anne Marie Valente, Christopher Semsarian, Steven D Colan, E John Orav
OBJECTIVE: The early natural history of sarcomere mutations and the evolution to hypertrophic cardiomyopathy (HCM) are poorly characterised. To describe phenotypic progression, we compared mutation carriers who developed HCM to those who did not during prospective longitudinal investigation. METHODS: Sarcomere mutation carriers without baseline left ventricular hypertrophy (LVH) were studied during participation in a pilot clinical trial testing diltiazem versus placebo...
September 2, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27562132/effectiveness-of-radiofrequency-catheter-ablation-of-outflow-tract-ventricular-arrhythmias-in-children-and-adolescents
#10
Xiao-Mei Li, He Jiang, Yan-Hui Li, Yan Zhang, Hai-Ju Liu, Hai-Yan Ge, Yi Zhang, Mei-Ting Li
Outflow tract ventricular arrhythmias (OTVAs) are common in children; however, experience is limited on their radiofrequency catheter ablation (RFCA). The purpose of this study was to assess the outcomes of mapping and ablation of pediatric OTVAs and to evaluate the role of ECG algorithms in distinguishing the origin of OTVAs. We compared retrospectively collected single-center data on 92 consecutive pediatric patients (58 male; age, 8.2 ± 2.9 [range 3.6-18] years) who underwent RFCA for OTVAs from 2009 to 2015...
December 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27545854/thrombosis-of-inferior-vena-cava-diagnosed-using-point-of-care-ultrasound-after-pediatric-near-syncope
#11
Shadi Lahham, Lester Tsai, Sean P Wilson, Samer Assaf, Roman Navarro, Faried Banimahd, Mohammad Subeh, Erik D Barton, Abigail Barbera, J Christian Fox
BACKGROUND: Venous thromboembolism (VTE) is extremely rare but under recognized in the pediatric population. Although the literature on the use of ultrasound to detect VTEs in adults is plentiful, little has been documented on its use in the pediatric population. CASE REPORT: We present a case of a healthy 16-year-old female who presented to our emergency department with 3 months of dyspnea on exertion and one episode of near-syncope. Point-of-care cardiac ultrasound identified an inferior vena cava thrombosis...
October 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27543703/atrial-chamber-remodelling-in-healthy-pre-adolescent-athletes-engaged-in-endurance-sports-a-study-with-a-longitudinal-design-the-child-study
#12
Flavio D'Ascenzi, Marco Solari, Francesca Anselmi, Silvia Maffei, Marta Focardi, Marco Bonifazi, Sergio Mondillo, Michael Henein
AIMS: Previous studies investigated the exercise-induced adaptation of left (LA) and right atrium (RA) in adults, but little is known about respective changes in the growing heart of children. We aimed to longitudinally investigate the effects of endurance training on biatrial remodelling in preadolescent athletes. METHODS AND RESULTS: Ninety-four children (57 endurance athletes, 37 sedentary controls; mean age 10.8±0.2 and 10.2±0.2years, respectively) were evaluated at baseline and after 5months by ECG and by two-dimensional, three-dimensional (3D) and speckle-tracking echocardiography...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27516375/electrocardiograms-of-children-and-adolescents-practicing-non-competitive-sports-normal-limits-and-abnormal-findings-in-a-large-european-cohort-evaluated-by-telecardiology
#13
Giuseppe Molinari, Natale Daniele Brunetti, Luigi Biasco, Sandro Squarcia, Yvonne Cristoforetti, Riccardo Bennicelli, Cecilia Del Vecchio, Cecilia Viacava, Carla Giustetto, Fiorenzo Gaita
OBJECTIVE: The objective of this study was to derive normal electrocardiographic values and to report the abnormal findings in a large contemporary European cohort of physically active children and young adolescents. METHODS: In a 3-month period, data derived from subjects aged between 3 and 14 years and referred to the Telecardiology Centre (Genoa, Italy) for electrocardiogram (ECG) evaluation as pre-participation screening for non-competitive sports were analyzed...
August 11, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27474357/a-phase-i-open-label-single-dose-safety-pharmacokinetic-and-tolerability-study-of-the-sumatriptan-iontophoretic-transdermal-system-in-adolescent-migraine-patients
#14
Dikla Gutman, Edward Hellriegel, Ernesto Aycardi, Marcelo E Bigal, Jeevan Kunta, Rohini Chitra, Sujay Kansagra, Orna Srur Kidron, Helena Knebel, Steven Linder, Yuju Ma, Mark Pierce, Paul K Winner, Ofer Spiegelstein
OBJECTIVE: To evaluate the safety, tolerability, and pharmacokinetics of sumatriptan delivered by the iontophoretic transdermal system (TDS) in adolescent patients. BACKGROUND: Since nausea can be a prominent and early symptom of migraine, nonoral treatment options are often required. Sumatriptan iontophoretic TDS is approved for the acute treatment of migraine in adults. The present study evaluates the pharmacokinetics of sumatriptan administered via the iontophoretic TDS in adolescents, contrasting the findings with historical data from adults...
September 2016: Headache
https://www.readbyqxmd.com/read/27452149/-depressive-symptoms-during-anorexia-nervosa-state-of-the-art-and-consequences-for-an-appropriate-use-of-antidepressants
#15
N Leblé, L Radon, M Rabot, N Godart
OBJECTIVE: Depressive comorbidity is often associated with anorexia nervosa (AN), and antidepressant medication is widely used although it does not rely on any convincing data in the scientific literature. Our objectives were: to summarize the epidemiological, physiological, psychopathological literature about the relation between AN and manifestations of depression, and to focus on the clinical trial data assessing the use of antidepressant medication in AN in order to clarify the strategy for the use of antidepressant in AN during adolescence...
July 21, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27428857/dimensions-of-adversity-physiological-reactivity-and-externalizing-psychopathology-in-adolescence-deprivation-and-threat
#16
Daniel S Busso, Katie A McLaughlin, Margaret A Sheridan
OBJECTIVE: Dysregulation of autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis function is a putative intermediate phenotype linking childhood adversity (CA) with later psychopathology. However, associations of CAs with autonomic nervous system and HPA-axis function vary widely across studies. Here, we test a novel conceptual model discriminating between distinct forms of CA (deprivation and threat) and examine their independent associations with physiological reactivity and psychopathology...
July 15, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27428303/pharmacokinetics-and-tolerability-of-single-ascending-doses-of-desvenlafaxine-administered-to-children-and-adolescents-with-major-depressive-disorder
#17
Robert L Findling, James Groark, Karen A Tourian, Sara A Ramaker, Deborah Chiles, Lingfeng Yang, Alice I Nichols
OBJECTIVE: To investigate the safety and pharmacokinetic profile of ascending doses of desvenlafaxine in children and adolescents with major depressive disorder. Assessment of the effect of desvenlafaxine on depression symptoms was exploratory. METHODS: The 8-week, open-label study included an initial 3.5-day inpatient period followed by a 7.5-week outpatient period. Children (7-11 years) received a single desvenlafaxine dose of 10, 25, 50, or 100 mg on day 1; adolescents (12-17 years) received desvenlafaxine 25, 50, 100, or 200 mg/day...
July 18, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27322729/decreased-false-positive-adolescent-pre-athletic-screening-with-seattle-criteria-interpreted-electrocardiograms
#18
Jamie N Colombo, Ricardo A Samson, Santiago O Valdes, Omar Meziab, David Sisk, Scott E Klewer
Sudden cardiac arrest is a rare but devastating cause of death in young adults. Electrocardiograms may detect many causes of sudden cardiac arrest, but are not routinely included in pre-athletic screening in the United States of America partly because of high rates of false-positive interpretation. To improve electrocardiogram specificity for identifying cardiac conditions associated with sudden cardiac arrest, an expert panel developed refined criteria known as the Seattle Criteria. Ours is the first study to compare standard electrocardiogram criteria with Seattle Criteria in 11- to 13-year-olds...
June 20, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27318810/physiological-response-to-social-evaluative-threat-in-adolescents-with-autism-spectrum-disorder
#19
E Kale Edmiston, Robin M Jones, Blythe A Corbett
The Trier Social Stress Test (TSST) was employed to study response to social evaluative threat in male adolescents with Autism Spectrum Disorder (ASD, n = 21) and typical development (n = 13). Participants wore a mobile electrocardiogram to collect heart rate data. There were significant group effects on respiratory sinus arrhythmia (RSA), a measure of parasympathetic nervous system function, with lower values in ASD (F = 4.97). Bivariate correlations also showed a significant relationship between parent reports of social problems and RSA response to the TSST (r = -0...
September 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27282010/sports-related-sudden-cardiac-injury-or-death
#20
REVIEW
Elizabeth Anne Greene, Ann Punnoose
Symptoms such as syncope and chest pain, especially if they are accompanied by palpitations or occur with exercise in any combination, require cardiac evaluation before adolescent athletes are allowed to return to the sports field. Some life-threatening conditions will likely be associated with a family history of HCM or LQTS, but the family history may not be discovered at the first medical visit. A family history of CPVT, for example, is hard to elicit unless this diagnosis has already been established in an affected family member...
December 2015: Adolescent Medicine: State of the Art Reviews
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