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https://www.readbyqxmd.com/read/30236381/trajectories-of-changes-in-glucose-tolerance-in-a-multiethnic-cohort-of-obese-youths-an-observational-prospective-analysis
#1
Alfonso Galderisi, Cosimo Giannini, Ram Weiss, Grace Kim, Veronika Shabanova, Nicola Santoro, Bridget Pierpont, Mary Savoye, Sonia Caprio
BACKGROUND: Type 2 diabetes is preceded by a prediabetic stage of impaired glucose tolerance that affects 10-23% of youth and is expected to double over the next decade. The natural history of impaired glucose tolerance and the determinants of β-cell dynamic response have never been investigated longitudinally in young people. We aimed to investigate the clinical and metabolic determinants of longitudinal glucose tolerance changes and β-cell function in a multiethnic cohort of obese youth...
October 2018: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/30234684/multimodality-imaging-single-center-cross-sectional-study-in-adolescents-or-young-adults-with-repaired-tetralogy-of-fallout
#2
Anna Balducci, Tammam Hasan, Andrea Donti, Gabriele Egidy Assenza, Luigi Lovato, Marianna Fabi, Valentina Gesuete, Daniela Prandstraller, Roberto Formigari, Luca Ragni, Emanuela Angeli, Gaetano D Gargiulo, Fernando M Picchio, Marco Bonvicini
BACKGROUND: Proper integration of multiple imaging modalities in the routine follow-up of patients with repaired tetralogy of Fallout (TOF) is poorly supported by data. We report our single center comparative study between cardiac magnetic resonance (CMR) and echocardiography to assess equipoise in the clinical utility of these two imaging methods in an unselected consecutive cohort of TOF patients referred to our outpatient clinic. MATERIAL AND METHODS: In this cross-sectional study, repaired TOF patients who underwent CMR and echocardiography within a 4-week period between 2010 and 2011 at our Center were included...
September 17, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/30232779/the-role-of-dennd1a-and-cyp19a1-gene-variants-in-individual-susceptibility-to-obesity-in-turkish-population-a-preliminary-study
#3
Ela Kadioglu, Beril Altun, Çağrı İpek, Esra Döğer, Aysun Bideci, Hadi Attaran, İsmet Çok
Single nucleotide polymorphisms (SNPs), the most common genetic variations in human genome, can manage the predisposition of certain complex diseases or situations such as obesity. Genetic polymorphisms also play an important role as they can impact a population's susceptibility to being overweight or obese and developing related chronic complications such as hypertension, coronary heart disease, diabetes and cancer. The present study comprised of 193 unrelated healthy volunteers (120 females and 73 males) with Turkish origin...
September 19, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30230998/case-262
#4
Andrew H Schapiro, Mantosh S Rattan, Ryan A Moore, Jonathan R Dillman
History A 17-year-old white male adolescent was re-evaluated for a withheld cardiac condition initially detected during prenatal imaging at an outside institution. He had previously experienced intermittent episodes of shortness of breath, chest pain, and palpitations with exertion, but more recently he had been asymptomatic. He had no other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or sudden cardiac death. At physical examination, the patient had a grade II/IV rumbling systolic murmur best heard at the left upper sternal border...
October 2018: Radiology
https://www.readbyqxmd.com/read/30218392/somatic-complaints-in-children-and-adolescents-with-social-anxiety-disorder
#5
Petra Sackl-Pammer, Zeliha Özlü-Erkilic, Rebecca Jahn, Andreas Karwautz, Eva Pollak, Susanne Ohmann, Türkan Akkaya-Kalayci
BACKGROUND: Associations of social anxiety disorder (SAD) with various somatic symptoms have been already reported in the literature several times. The present study investigated somatic complaints in children and adolescents with SAD compared to controls and evaluated the relationship between social anxiety and somatic symptom severity. METHODS: Thirty children and adolescents with SAD were compared with 36 healthy age-matched controls. Self-reported fears were assessed using the Phobiefragebogen für Kinder und Jugendliche (PHOKI); emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL/4-18); and the Gießener Beschwerdebogen für Kinder und Jugendliche (GBB-KJ) was used to assess 59 somatic symptoms...
September 14, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/30217690/an-adolescent-with-left-ventricular-noncompaction-and-ebstein-anomaly-presenting-with-advanced-heart-failure-discharge-from-hospital-with-a-biventricular-assist-device
#6
Bibhuti B Das, Maryanne Chrisant, Gerald Lavandosky, Megan Zakrzewski, Robert Winchester, Immanuel Turner, Steven Bibevski, Frank Scholl
No abstract text is available yet for this article.
September 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30216863/increases-in-orbitofrontal-cortex-thickness-following-antidepressant-treatment-are-associated-with-changes-in-resting-state-autonomic-function-in-adolescents-with-major-depression-preliminary-findings-from-a-pilot-study
#7
Julian Koenig, Melinda Westlund Schreiner, Bonnie Klimes-Dougan, Benjamin Ubani, Bryon A Mueller, Kelvin O Lim, Michael Kaess, Kathryn R Cullen
In adults with major depressive disorder (MDD), effective treatment has been associated with increases in both heart rate variability (HRV) and cortical thickness. However, the impact of treatment on these indices has not yet been examined in adolescents. Cortical thickness and HRV were measured in twelve adolescents with MDD before and after 8 weeks of treatment with a selective serotonin reuptake inhibitor (SSRI). We examined treatment-related changes in depression symptoms, HRV, heart rate (HR), and cortical thickness, and analyzed correlations among these change indices...
August 24, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/30216203/sustained-viral-response-in-genotype-4-chronic-hcv-infected-children-and-adolescents-treated-with-sofosbuvir-ledipasvir
#8
Hanaa El-Karaksy, Engy Adel Mogahed, Hala Abdullatif, Carolyne Ghobrial, Mona S El-Raziky, Nehal El-Koofy, Mortada El-Shabrawi, Haytham Ghita, Sherif Baroudy, Sawsan Okasha
OBJECTIVES: Recently, direct acting antivirals (DAAs), sofosbuvir (SOF) combined with ledipasvir (LED) were approved for treatment of HCV infected children 12 years of age and older or weighting at least 35 kg for all HCV genotypes. The aim of this study was to assess the safety and efficacy of SOF/LED in genotype 4 HCV-infected Egyptian children and adolescents. METHODS: This observational study included 40 consecutive HCV infected children aged 12 to <18 years old or weighing >35 kg, both treatment-naive and treatment experienced...
July 17, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30215629/tnf-inhibitors-for-psoriasis
#9
Margot Chima, Mark Lebwohl
Tumor necrosis factor (TNF)-α has been identified as a key cytokine mediating cutaneous inflammation in the pathogenesis of psoriasis. The TNF inhibitors (TNFi's) infliximab, adalimumab, and etanercept are efficacious, Food and Drug Administration-approved medications for the treatment of moderate-to-severe plaque psoriasis. Each drug has a unique pharmacological profile that can have therapeutic implications when choosing a particular TNFi for a patient. An understanding of these idiosyncrasies can help guide therapeutic decisions for patients with psoriasis that also have inflammatory bowel disease, hepatitis C, hepatitis B, latent tuberculosis, obesity, cardiovascular disease, and heart failure...
September 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/30211814/differences-in-obesity-among-black-and-white-children-adolescents-and-adults-with-congenital-heart-disease
#10
Jamie L Jackson, Tondi Harrison, Sarah A Keim
BACKGROUND: Congenital heart disease (CHD) survivors have an elevated risk for obesity-related comorbidities, but little is known about racial differences in obesity rates for this population. OBJECTIVE: The authors aimed to compare rates of obesity in CHD survivors to national estimates using National Health and Nutrition Examination Assessment Survey (NHANES) and to characterize racial disparities in obesity among CHD survivors across age ranges. METHODS: Retrospective chart review included 4496 CHD survivors (4050 white and 446 black) with a range of lesion severities from a pediatric and an adult medical center...
September 11, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/30210878/a-long-term-survivor-with-tetralogy-of-fallot-treated-only-with-the-classical-blalock-taussig-shunt
#11
Yu Yamada, Tomoko Ishizu, Hidekazu Tsuneoka, Yutaka Eki, Hitoshi Horigome
The prognosis of tetralogy of Fallot (TOF) treated only with Blalock-Taussig shunt (BTS) operation is unclear. A woman with TOF underwent classic BTS operation at 10 years of age. Despite no medication, she delivered two children and worked without apparent heart failure. At 72 years of age, she complained of dyspnea on exertion and leg edema. The cardiac angiogram revealed a well-patent BTS and severely stenotic right ventricular outflow tract. Right heart catheterization showed adequately maintained pulmonary blood flow with slight pulmonary arterial hypertension...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/30209810/parental-uncertainty-about-transferring-their-adolescent-with-congenital-heart-disease-to-adult-care
#12
Åsa Burström, Mariela Acuna Mora, Maria Öjmyr-Joelsson, Carina Sparud-Lundin, Annika Rydberg, Katarina Hanseus, Björn Frenckner, Margret Nisell, Philip Moons, Ewa-Lena Bratt
AIMS: To study parent's levels of uncertainty related to the transfer from pediatric to adult care in adolescents with Congenital Heart Disease (CHD) and to identify potentially correlating factors. BACKGROUND: Parents acknowledge that during transition they struggle with finding ways of feeling secure in handing over the responsibility and letting go of control. Well-prepared and informed parents who feel secure are most likely better skilled to support their adolescent and to hand over the responsibility...
September 12, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/30209524/normal-values-for-left-ventricular-mass-in-relation-to-lean-body-mass-in-child-and-adolescent-athletes
#13
Hubert Krysztofiak, Marcel Młyńczak, Andrzej Folga, Wojciech Braksator, Łukasz A Małek
It has been demonstrated that regular sport activity in children leads to physiological changes in the heart including increased left ventricular (LV) myocardial thickness and mass (LVM). The aim of the study was to establish the first specific normal values of LVM for child and adolescent athletes. Parasternal long-axis, 2D-guided echocardiographic measurements were obtained from a group of 791 Caucasian child athletes (age 5-18 years, 58.7% boys). For the preparation of normative data, LVM-for-lean body mass (LBM) reference curves were constructed using the LMS method...
September 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/30199516/adapted-motivational-interviewing-to-promote-exercise-in-adolescents-with-congenital-heart-disease-a-pilot-trial
#14
Adam McKillop, Sherry L Grace, Gabriela Lima de Melo Ghisi, Kenneth R Allison, Laura Banks, Adrienne H Kovacs, Jane E Schneiderman, Brian W McCrindle
PURPOSE: To assess a motivational interviewing (MI) intervention to improve moderate-to-vigorous physical activity (MVPA) in adolescents with congenital heart disease. METHODS: Intervention participants received one-on-one telephone-based adapted MI sessions over 3 months. Outcomes were acceptability, change mechanisms (stage of change and self-efficacy), and limited efficacy (physical activity, fitness, and quality of life). RESULTS: Thirty-six participants were randomized...
September 6, 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/30198928/a-study-of-practice-behavior-for-endotracheal-intubation-site-for-children-with-congenital-heart-disease-undergoing-surgery-impact-of-endotracheal-intubation-site-on-perioperative-outcomes-an-analysis-of-the-society-of-thoracic-surgeons-congenital-cardiac-anesthesia
#15
Nathaniel H Greene, Edmund H Jooste, Dylan P Thibault, Amelia S Wallace, Alice Wang, David F Vener, Roland A Matsouaka, Marshall L Jacobs, Jeffrey P Jacobs, Kevin D Hill, Warwick A Ames
BACKGROUND: In adults undergoing cardiopulmonary bypass surgery, oral intubation is typically preferred over nasal intubation due to reduced risk of sinusitis and infection. In children, nasal intubation is more common and sometimes preferred due to perceived benefits of less postoperative sedation and a lower risk for accidental extubation. This study sought to describe the practice of nasal intubation in the pediatric population undergoing cardiopulmonary bypass surgery and assess the risks/benefits of a nasal route against an oral one...
September 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30190185/adolescent-stress-management-in-a-primary-care-clinic
#16
Elizabeth B Mason, Kimberly Burkhart, Rina Lazebnik
INTRODUCTION: The American Academy of Pediatrics recommends that adolescents be screened for mental health concerns and receive anticipatory guidance on stress management strategies. METHODS: Eighty-six participants (50 participants in the intervention group; 36 participants in the control group) participated in the study. Intervention group participants received training in diaphragmatic breathing, progressive muscle relaxation, and use of no-cost/low-cost exercise options...
September 3, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/30188881/vital-signs-state-level-variation-in-nonfatal-and-fatal-cardiovascular-events-targeted-for-prevention-by-million-hearts-2022
#17
Matthew D Ritchey, Hilary K Wall, Pamela L Owens, Janet S Wright
INTRODUCTION: Despite its preventability, cardiovascular disease remains a leading cause of morbidity, mortality, and health care costs in the United States. This study describes the burden, in 2016, of nonfatal and fatal cardiovascular events targeted for prevention by Million Hearts 2022, a national initiative working to prevent one million cardiovascular events during 2017-2021. METHODS: Emergency department (ED) visits and hospitalizations were identified using Healthcare Cost and Utilization Project databases, and deaths were identified using National Vital Statistics System data...
September 7, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/30187760/the-study-of-laryngoscopic-and-autonomic-patterns-in-exercise-induced-laryngeal-obstruction
#18
Adrianna C Shembel, Christopher J Hartnick, Glenn Bunting, Catherine Ballif, Jessie Vanswearingen, Susan Shaiman, Aaron Johnson, Vanessa de Guzman, Katherine Verdolini Abbott
OBJECTIVES: (1) Identify laryngeal patterns axiomatic to exercise-induced laryngeal obstruction (EILO) and (2) investigate the role of autonomic function in EILO. METHODS: Twenty-seven athletic adolescents (13 EILO, 14 control) underwent laryngoscopy at rest and exercise. Glottal configurations, supraglottic dynamics, systolic blood pressure responses, and heart rate recovery were compared between conditions and groups. RESULTS: Inspiratory glottal angles were smaller in the EILO group than the control group with exercise...
September 6, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/30173377/anorexia-nervosa-and-heart-disease-a-systematic-review
#19
REVIEW
Stefano Giovinazzo, S G Sukkar, G M Rosa, A Zappi, G P Bezante, M Balbi, C Brunelli
Anorexia nervosa (AN) is an eating disorder that most frequently afflicts females in adolescence. In these subjects, cardiovascular complications are the main cause of morbidity and mortality. Aim of this review is to analyze the hemodynamic, pro-arrhythmic and structural changes occurring during all phases of this illness, including re-feeding. A systematic literature search was performed on studies in the MEDLINE database, from its inception until September 2017, with PUBMED interface focusing on AN and cardiovascular disease...
September 1, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/30168607/dietary-inflammatory-index-and-cardiovascular-risk-factors-in-spanish-children-and-adolescents
#20
María Correa-Rodríguez, Emilio González-Jiménez, Blanca Rueda-Medina, María I Tovar-Gálvez, Robinson Ramírez-Vélez, Jorge E Correa-Bautista, Jacqueline Schmidt-RioValle
Dietary inflammatory potential is an established risk factor for adverse cardiovascular events. In this study we analyzed the relation between the Dietary Inflammatory Index (DII) and cardiovascular risk factors, based on anthropometric, body composition, blood pressure, and heart rate parameters in children and adolescents. We conducted a cross-sectional study of 428 Spanish schoolchildren (mean age 12.32 ± 1.84), whose DII was calculated, based on a 24-hr diet recall over 3 days. Anthropometric measurements were taken, and body composition analyzed by bioelectrical impedance analysis...
August 31, 2018: Research in Nursing & Health
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