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Jaume Puig-Junoy, Natàlia Pascual-Argenté
BACKGROUND: Asthma is responsible for a large number of doctor and emergency visits due to exacerbations and inadequate control of the disease, which give rise to very high associated economic costs. The social cost of asthma comprises both the healthcare and non-healthcare costs. The purpose of this study was to analyse up-to-date estimates of the social cost of asthma, with special reference to the influence of level of severity and degree of control. METHODS: A systematic review of original cost-of-illness studies of asthma published in English or Spanish between January 2004 and December 2014 and indexed in PubMed, IBECS or IME was conducted...
March 9, 2017: Revista Española de Salud Pública
Dixis Figueroa Pedraza, Erika Morganna Neves de Araujo
Objective: to describe the causes of hospitalization of Brazilian children under five years old. Methods: this is a systematic review of articles published from 2008 to 2015, searched in the databases Medline and LILACS; selected studies were critically analyzed through a validated instrument. Results: eleven articles were included, four of them are ecological and seven are cross-sectional studies; respiratory diseases (n=5), parasitic infections (n=4) and perinatal diseases (n=2) were the main causes for hospitalizations in the reviwed articles; in the studies that analyzed the sensitive conditions, pneumonia (n=6), gastroenteritis (n=5), and asthma (n=5) were the mais causes pointed out...
January 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Dzmitry Shcharbin, Natallia Shcharbina, Volha Dzmitruk, Elzbieta Pedziwiatr-Werbicka, Maksim Ionov, Serge Mignani, F Javier de la Mata, Rafael Gómez, Maria Angeles Muñoz-Fernández, Jean-Pierre Majoral, Maria Bryszewska
Dendrimers are hyperbranched polymers belonging to the huge class of nanomedical devices. Their wide application in biology and medicine requires understanding of the fundamental mechanisms of their interactions with biological systems. Summarizing, electrostatic force plays the predominant role in dendrimer-protein interactions, especially with charged dendrimers. Other kinds of interactions have been proven, such as H-bonding, van der Waals forces, and even hydrophobic interactions. These interactions depend on the characteristics of both participants: flexibility and surface charge of a dendrimer, rigidity of protein structure and the localization of charged amino acids at its surface...
April 1, 2017: Colloids and Surfaces. B, Biointerfaces
Li-Hong Li, Jing Wang, Xiao-Yan Ke
Leukemia carring translocation at the 11q23 locus is referred to MLL-rearranged (MLL-r) leukemia, and the occurrence of this genetic lesion is associated with a poor prognosis. The most common translocation chromosomes are chromosomes 4,9 and 10. Recently MLL protein was found to interact with DOT1L (DOT1-like) protein, which can promote leukemogenesis. A new DOT1L inhibitor EPZ-5676 can selectively inhibit proliferation, promote apoptosis and differentiation, which was also found to act synergistically with anti-AML (acute myeloid leukemia) and anti-ALL (acute lymphoblastic leukemia) drugs...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Miguel A Herrera-Rueda, Gabriel Navarrete-Vázquez, Francisco Aguirre-Crespo, Maria Guadalupe Maldonado-Velazquez, Jorge Vergara-Galicia, Hilario Chi Canul, Xerardo Garcia-Mera, Francisco J Prado-Prado
In nature, pathogenic parasite species with different susceptibility patterns of antiparasitic drugs abound. In this sense, natural products derived from plants are a potency for drugs with potential antiparasitic activity. Unfortunately, there are many metabolites and studying all of them would be costly in terms of money and resources. To this end, theoretical studies such as QSAR models could be useful. These, for the most part, predict the biological activity of the drugs against a single species of parasite...
2017: Current Drug Targets
Funda Akpinar, Berna Dilbaz, Derya A Cırık, Saynur Yilmaz, Sadiman Kiykac, Ertugrul Karahanoglu, Leyla Mollamahmutoglu
To investigate factors associated with the response to ovarian stimulation in patients with polycystic ovary syndrome. Methods: The records of patients with polycystic ovary syndrome and infertility who underwent ovulation induction with clomiphene citrate were reviwed between January 2011 and December 2014 in Etlik Zübeyde Hanim Women's Health Training and Research Hospital Ankara, Turkey. The anthropometric and endocrine factors of patients who were resistant to treatment at a dose of 150 mg/day (n=84) were compared with those who responded with growth of at least one graaffian follicle at a dose of 50 mg/day (n=342)...
November 2016: Saudi Medical Journal
Bashir Lawal, Oluwatosin Kudirat Shittu, Adamu Yusuf Kabiru, Ali Audu Jigam, Maimuna Bello Umar, Eustace Bonghan Berinyuy, Blessing Uchenna Alozieuwa
Malaria remains an overwhelming infectious disease with significant health challenges in African and other endemic countries globally. Resistance to antimalarial drugs has become one of the most momentous challenges to human health, and thus has necessitated the hunt for new and effective drugs. Consequently, few decades have witnessed a surfeit of research geared to validate the effectiveness of commonly used traditionally medicines against malaria fever. The present review work focuses on documenting natural products from African whose activity has been reported in vivo or in vitro against malaria parasite...
October 2015: Journal of Intercultural Ethnopharmacology
Juan Zhang, Jing-Shu Shi, Jian Li
MSC-exosomes are homogeneous menbrane vesicles with diameter 40-100 nm, derived from mesenchymal stem cells at physiological or pathology conditions. MSC-exosomes contain a great quantity and a wide variety of bioactive substances, such as proteins and miRNA. MSC-exosomes transfer bioactive substances to recipient cells to affect their functions through membrane fusion or endocytosis, which like the storage pools of signal vehicles for cell-to-cell comunication in vivo. MSC-exosomes can mimic the beneficial effect of MSC treatment, such as the promotion of tissue repair or the immune regulation...
August 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
Bhaswati Sinha, Muni Rubens
CONTEXT: Advancement in HIV treatment has evolved over the last two decades with the discovery of new drugs and approaches. Studies have demonstrated that HIV-infected individuals have elevated immune activation even during effective antiretroviral therapy. Persistently elevated immune activation has been one of the main obstacles against developing an effective approach for curing HIV. OBJECTIVE: This review examines the mechanism of microbial translocation in HIV-infected individuals and currently investigated potential therapeutic approaches...
April 2014: Immunopharmacology and Immunotoxicology
I Terashima
Since 1986, non-uniform photosynthesis over the leaf area that may be attributed to patchy stomatal closure, has been an important issue in stress physiology of photosynthesis. In this review, I first outline the gaseous environment within the intercellular spaces, because this is the most fundamental background of this problem. Then, recent studies approaching non-uniform photosynthesis are reviwed. After examining techniques for the detection of non-uniform photosynthesis or non-uniform stomatal aperture, results of the relevant studies are discussed for respective stress factors, seeking causes and consequences of non-uniform photosynthesis...
March 1992: Photosynthesis Research
Miguel J Mora Durbán, Miguel Ramírez Backhaus
No abstract text is available yet for this article.
April 2013: Archivos Españoles de Urología
Hao Dai, Wei-Tao Zhai, Ling-Chun Wang, Yue-Lin Xu, Sheng Ding, Jun Xie, Feng Gao, Ying-Hui Ma
OBJECTIVE: To introduce the procedure of the 1st ray stabilization combined with resection of the lesser metatarsal heads for patient with severe forefoot deformity caused by rheumatoid arthritis (RA) and evaluate the short to mid-term clinical results. METHODS: From Oct. 2006 to Aug. 2010,97 patients (129 feet) aged from 36 to 67 years (average 54), with forefoot deformity caused by rheumatoid arthritis were reviwed. There were 88 males and 9 females,65 single lateral involved and 32 bilateral involved, the average duration of disease was 17 years (6 to 32 years)...
October 2012: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Dorte Lyhne, Jørgen Lock-Andersen, Karin Dahlstrøm, K T Drzewiecki, Eva Balslev, Aida Muhic, Anders Krarup-Hansen
Merkel cell carcinoma (MCC) is a rare, aggressive, skin cancer of obscure histogenesis, the incidence of which is rising. There is no consensus on the optimal treatment. Our aim was to evaluate the staging, investigation, treatment, and follow-up of MCC in eastern Denmark, and to investigate the incidence. We suggest guidelines for treatment. First we reviewed the medical records of 51 patients diagnosed with MCC from 1995 until 2006 in eastern Denmark. The nation-wide incidence of MCC was extracted from the Danish Cancer Registry for the calculations for the period 1986-2003...
December 2011: Journal of Plastic Surgery and Hand Surgery
Alavi Nasrinossadat, Fonooni Ladan, Ensani Fereshte, Olfatbakhsh Asieh, Chaman Reza, Sadjadian Akramossadat, Mehra Golshan
INTRODUCTION: The widespread use of improved mammographic techniques has led to increased detection of nonpalpable breast masses. Preoperative localization is important for reducing false negative results and decreasing the size of tissue resection needed and the resulting breast deformity. We used ultrasound guided methylen blue injection in the mass for localization of breast masses that were clinically nonpalpable but detectable by ultrasound. MATERIALS AND METHODS: 57 masses from 51 patients were marked 20 to 180 minutes before surgery with 0...
2011: Asian Pacific Journal of Cancer Prevention: APJCP
Márcia Mie Uchimura, Juliana Battiston, Patrícia Moreira, Carla Martinez Menini Stahlschmidt, Fábio Luiz Lubachevski
OBJECTIVE: Epidemiologically analyze the use of the pericardiostomy in the diagnosis of cardiac injury in a trauma universitary hospital in Curitiba. METHODS: Observacional, retrospective study, analyzing medical records of patients who were submitted to penetrating or blunt trauma, in a period of 06 years, in Urgency and Emergency unit of Cajuru Universitary Hospital. RESULTS: 120 patients had been submitted to pericardiostomy in the period above related...
April 2010: Revista do Colégio Brasileiro de Cirurgiões
Verónica Carrasco-Sanchez, Mario J Simirgiotis, Leonardo S Santos
This short review presents new insights on the mechanism and online monitoring using electrospray ionization tandem mass spectrometry (ESI-MS/MS) of Morita-Baylis-Hillman (MBH) reactions. MBH reactions are versatile carbon-carbon organocatalyzed bond forming reactions, making them environmentally friendly due to general organocatalysts employed. The organocatalyst behavior, which controls the transition state and thus the enantioselectivities in the obtained products, is very important in the performance of asymmetric MBH transformations...
2009: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shuichi Yamamoto
No abstract text is available yet for this article.
January 2009: Nippon Ganka Gakkai Zasshi
Ichiro Arioka, Shunichiro Dohi, Shizuyuki Dohi, Kenya Sakai
BACKGROUND AND AIM: Calcium channel blockers (CCBs) have been reported to reduce the incidence of stroke in hypertensive patients. CCBs are also commonly used to treat patients with angina pectoris (AP). However, there are very few reports on their effects on cardiovascular events, including stroke and end-stage renal disease (ESRD), in patients with AP. This study was designed to assess the differences among CCBs regarding the occurrence of cardiovascular events in patients with AP. METHODS: Clinical records of 226 patients with AP who had received treatment with CCBs in hospital from January 1, 1993 to December 31, 2006 were reviwed...
2008: Arzneimittel-Forschung
D S Ajarim
A five year experience in 21 patients with superior vena caval obstruction (SVCO) was reviwed. SVCO was due to benign conditions in four patients (19%) and malignant tumors in 17 patients (81%). Lymphoma and lung cancer were the most common causes encountered. The most common symptoms and signs were facial swelling, shortness of breath, jugular venous distention, swelling of face and arms, and engorgement of thoracic veins. Benign disorders had a longer duration of symptoms before presentation and required longer time to make the diagnosis than in malignant disorders...
January 1992: Annals of Saudi Medicine
Tomoaki Tanaka, Hidenori Kawashima, Katsuyuki Kuratsukuri, Kazunobu Sugimura, Tatsuya Nakatani
Approximately 70% of patients with advanced prostate cancer have bone metastases, which are associated with considerable skeletal morbidity, accompanied by severe bone pain that requires narcotics or palliative radiation therapy, pathological fractures, spinal cord compression and hypercalcemia of malignancy (HCM), which consequentiy lower the patient's quality of life. Bisphosphonates, potent inhibitors of osteoclast activity and survival, therefore inhibiting osteoclast-mediated bone absorption, transiently palliative bone pain and decrease analgesic usage in patients who have hormone-refractory prostate cancer (HRPC) with bone metastases...
June 2006: Hinyokika Kiyo. Acta Urologica Japonica
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