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https://www.readbyqxmd.com/read/29782637/luteolin-ameliorates-rat-myocardial-ischemia-reperfusion-injury-through-peroxiredoxin-ii-activation
#1
Bo Wei, Qiao Lin, Ya-Ge Ji, Yi-Can Zhao, Li-Na Ding, Wen-Juan Zhou, Li-Hua Zhang, Chuan-Yu Gao, Wen Zhao
BACKGROUND AND PURPOSE: Antioxidants provide a promising therapeutic effect for the cardiovascular disease. Luteolin (LUT), a polyphenolic bioflavonoid, is known to confer cardioprotection, although the underlying mechanism, especially the role of LUT on the antioxidant enzymes (e.g. peroxiredoxin family, PRXs), remains elusive. EXPERIMENTAL APPROACH: The current study was designed to evaluate the impact of LUT on MI/R injury in vivo and in vitro, as well as the underlying mechanism with a focus on PRXs signaling...
May 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29778464/peroxiredoxin-2-deficiency-accelerates-age-related-ovarian-failure-through-the-reactive-oxygen-species-mediated-jnk-pathway-in-mice
#2
Sun-Ji Park, Jung-Hak Kim, Dong Gil Lee, Jin-Man Kim, Dong-Seok Lee
Reactive oxygen species (ROS) produced in biological reactions have been shown to contribute to ovarian aging. Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that protects cells by scavenging ROS; however, its effect on age-related, oxidative stress-associated ovarian failure has not been reported. Here, we investigated its role in age-related ovarian dysfunction and 4-vinylcyclohexene diepoxide (VCD)-induced premature ovarian failure using Prx2-deficient mice. Compared to those in wildtype (WT) mice, serum levels of anti-Müllerian hormone, 17β-estradiol, and progesterone and numbers of follicles and corpora lutea were significantly lower in 18-month-old Prx2-/- mice...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29753074/kinetic-and-stoichiometric-constraints-determine-the-pathway-of-h-2-o-2-consumption-by-red-blood-cells
#3
Florencia Orrico, Matías N Möller, Adriana Cassina, Ana Denicola, Leonor Thomson
Red blood cells (RBC) are considered as a circulating sink of H2 O2 , but a significant debate remains over the role of the different intraerythocyte peroxidases. Herein we examined the kinetic of decomposition of exogenous H2 O2 by human RBC at different cell densities, using fluorescent and oxymetric methods, contrasting the results against a mathematical model. Fluorescent measurements as well as oxygen production experiments showed that catalase was responsible for most of the decomposition of H2 O2 at cell densities suitable for both experimental settings (0...
May 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29747716/effects-of-antiparkinson-medication-on-cognition-in-parkinson-s-disease-a-systematic-review
#4
Marc-André Roy, Maxime Doiron, Jessica Talon-Croteau, Nicolas Dupré, Martine Simard
OBJECTIVE: This study aimed to systematically review the effects of currently prescribed antiparkinson medication on cognition in patients with mild-to-moderate Parkinson's disease (PD) who were either cognitively intact or mildly impaired. METHODS: English- and French-language studies published between 1969 and 2017 were accessed via MedLine, PsychNET, EMBASE and EBSCO databases. Methodological quality (MQ) was evaluated with the quality assessment instrument of the Cochrane Collaboration Depression, Anxiety and Neurosis Review (scores from 0% to 44% indicate very low quality; scores from 45% to 64% indicate low quality; scores from 65% to 84% indicate medium quality; and scores from 85% to 100% indicate high quality)...
May 11, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29728926/microstructural-magnetic-and-optical-properties-of-pr-doped-perovskite-manganite-la-0-67-ca-0-33-mno-3-nanoparticles-synthesized-via-sol-gel-process
#5
Weiren Xia, Heng Wu, Piaojie Xue, Xinhua Zhu
We report on microstructural, magnetic, and optical properties of Pr-doped perovskite manganite (La1 - x Prx )0.67 Ca0.33 MnO3 (LPCMO, x = 0.0-0.5) nanoparticles synthesized via sol-gel process. Structural characterizations (X-ray and electron diffraction patterns, (high resolution) TEM images) provide information regarding the phase formation and the single-crystalline nature of the LPCMO systems. X-ray and electron diffraction patterns reveal that all the LPCMO samples crystallize in perovskite crystallography with an orthorhombic structure (Pnma space group), where the MnO6 octahedron is elongated along the b axis due to the Jahn-Teller effect...
May 4, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29705372/kaempferol-protects-against-gamma-radiation-induced-mortality-and-damage-via-inhibiting-oxidative-stress-and-modulating-apoptotic-molecules-in-vivo-and-vitro
#6
Jing Wang, Tiejun Li, Jingjing Feng, Li Li, Rong Wang, Hao Cheng, Yongfang Yuan
To investigate the potential protective effect of kaempferol, a representative flavonoid, against radiation induced mortality and injury in vivo and vitro.C57BL/6 male mice and human umbilical venous endothelial cells (HUVECs) were pretreated with kaempferol before radiation. We found that kaempferol can effectively increase 30-day survival rate after 8.5 Gy lethal total body irradiation (TBI). Mice were sacrificed at 7th day after 7 Gy TBI, we found kaempferol against radiation-induced tissues damage, by inhibiting the oxidative stress, and attenuating morphological changes and cell apoptosis...
April 20, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29696577/expression-of-the-serotonin-receptor-2b-in-uveal-melanoma-and-effects-of-an-antagonist-on-cell-lines
#7
Cindy Weidmann, Julie Bérubé, Léo Piquet, Arnaud de la Fouchardière, Solange Landreville
Uveal melanoma (UM) is the most common primary tumor in the adult, and disseminates to the liver in half of patients. A 15-gene expression profile prognostic assay allows to determine the likelihood of metastasis in patients using their ocular tumor DNA, but a cure still remains to be discovered. The serotonin receptor 2B represents the discriminant gene of this molecular signature with the greatest impact on the prognosis of UM. However, its contribution to the metastatic potential of UM remains unexplored...
April 25, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29689157/ph-responsive-coacervate-droplets-formed-from-acid-labile-methylated-polyrotaxanes-as-an-injectable-protein-carrier
#8
Kei Nishida, Atsushi Tamura, Nobuhiko Yui
In prior research, it has been demonstrated that methylated β-cyclodextrins-threaded acid-labile polyrotaxanes (Me-PRXs) exhibit a lower critical solution temperature (LCST) and form coacervate droplets above their LCST. In this study, the encapsulation of proteins in coacervate droplets and the pH-responsive release of proteins, through the acid-induced dissociation of the Me-PRX, were investigated. The coacervate droplets encapsulate various proteins, such as bovine serum albumin (BSA), lysozyme, and β-galactosidase, at pH 7...
April 24, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29674526/galectin-3-downregulates-antioxidant-peroxiredoxin-4-in-human-cardiac-fibroblasts-a-new-pathway-to-induce-cardiac-damage
#9
Jaime Ibarrola, Vanessa Arrieta, Rafael Sádaba, Ernesto Martínez-Martínez, Amaia García-Peña, Virginia Alvarez, Amaya Fernández-Celis, Alicia Gainza, Enrique Santamaría, Joaquin Fernández-Irigoyen, Victoria Cachofeiro, Guillermo Zalba, Renaud Fay, Patrick Rossignol, Natalia López-Andrés
Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress in human cardiac fibroblasts, in experimental animal models and in human aortic stenosis (AS). Using proteomics and immunodetection approaches, we have identified that Gal-3 down-regulated the anti-oxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. In parallel, Gal-3 increased peroxide, nitrotyrosine, malondialdehyde and N-carboxymethyl-lysine levels and decreased total antioxidant capacity...
April 19, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29665012/wavelet-pressure-reactivity-index-a-validation-study
#10
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Peter J Hutchinson, Xiao Hu, Peter Smielewski, Ken Brady
KEY POINTS: The brain is vulnerable to damage from too little or too much blood flow. A physiological mechanism called cerebral autoregulation (CA) exists to maintain stable blood flow even if cerebral perfusion pressure (CPP) is changing. A robust method for assessing CA is not yet available. There are still some problems with the traditional measure, the pressure reactivity index (PRx). We introduced a new method, wavelet transform method (wPRx) to assess CA using data from two sets of controlled hypotension experiments in piglets: One set with artificially manipulated ABP oscillations; the other group were spontaneous ABP waves...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29651243/pr-toxin-biosynthesis-genetic-regulation-toxicological-potential-prevention-and-control-measures-overview-and-challenges
#11
REVIEW
Manish K Dubey, Mohd Aamir, Manish S Kaushik, Saumya Khare, Mukesh Meena, Surendra Singh, Ram S Upadhyay
Out of the various mycotoxigenic food and feed contaminant, the fungal species belonging to Penicillium genera, particularly Penicillium roqueforti is of great economic importance, and well known for its crucial role in the manufacturing of Roquefort and Gorgonzola cheese. The mycotoxicosis effect of this mold is due to secretion of several metabolites, of which PR toxin is of considerable importance, with regard to food quality and safety challenges issues. The food products and silages enriched with PR toxin could lead into damage to vital internal organs, gastrointestinal perturbations, carcinogenicity, immunotoxicity, necrosis, and enzyme inhibition...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29648985/feasibility-of-telemetric-intracranial-pressure-monitoring-in-the-neuro-intensive-care-unit
#12
Alexander Lilja-Cyron, Jesper Kelsen, Morten Andresen, Kåre Fugleholm, Marianne Juhler
Intracranial pressure (ICP) monitoring is crucial in the management of acute neurosurgical conditions such as traumatic brain injury (TBI). However, pathological ICP may persist beyond the admission to the neuro intensive care unit (NICU). We investigated the feasibility of telemetric ICP monitoring in the NICU, as this technology provides the possibility of long-term ICP assessment beyond NICU discharge. In this prospective investigation, we implanted telemetric ICP sensors (Raumedic Neurovent-P-tel) instead of conventional, cabled ICP sensors in patients undergoing decompressive craniectomy...
May 3, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29623298/a-murine-model-of-charcot-marie-tooth-disease-4f-reveals-a-role-for-the-c-terminus-of-periaxin-in-the-formation-and-stabilization-of-cajal-bands
#13
Diane L Sherman, Peter J Brophy
Charcot-Marie-Tooth (CMT) disease comprises up to 80 monogenic inherited neuropathies of the peripheral nervous system (PNS) that collectively result in demyelination and axon degeneration. The majority of CMT disease is primarily either dysmyelinating or demyelinating in which mutations affect the ability of Schwann cells to either assemble or stabilize peripheral nerve myelin. CMT4F is a recessive demyelinating form of the disease caused by mutations in the Periaxin ( PRX ) gene . Periaxin (Prx) interacts with Dystrophin Related Protein 2 (Drp2) in an adhesion complex with the laminin receptor Dystroglycan (Dag)...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29620243/knockdown-of-peroxiredoxin-v-increases-glutamate%C3%A2-induced-apoptosis-in-ht22-hippocampal-neuron-cells
#14
Gui-Nan Shen, Lei Liu, Li Feng, Yu Jin, Mei-Hua Jin, Ying-Hao Han, Cheng-Hao Jin, Yong-Zhe Jin, Dong-Soek Lee, Tae Ho Kwon, Yu-Dong Cui, Hu-Nan Sun
High concentrations of glutamate may mediate neuronal cell apoptosis by increasing intracellular reactive oxygen species (ROS) levels. Peroxiredoxin V (Prx V), a member of the Prx family, serves crucial roles in protecting cells from oxidative stress. The present study investigated the regulatory effect of Prx V on glutamate‑induced effects on viability and apoptosis in HT22 cells. Western blotting was used for protein expression analysis and Annexin V/PI staining and flow cytometry for determination of apoptosis...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29606433/changes-in-phenolic-acid-composition-and-associated-enzyme-activity-in-shoot-and-kernel-fractions-of-brown-rice-during-germination
#15
Dong-Hwa Cho, Seung-Taik Lim
Phenolic acid composition and activities of two associated enzymes such as PAL (phenylalanine ammonia-lyase) and CW-PRX (cell wall peroxidase) in brown rice (BR) were examined during a germination for 4 days. Shoot and kernel fractions of the germinated brown rice were separated, and soluble extracts and insoluble residues of the fractions were analyzed. In the shoot fraction, the PAL activity and soluble phenolic acid content reached to its maximum on the second day of atmospheric germination, and decreased thereafter...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29596001/identification-of-candidate-genes-involved-in-the-salt-tolerance-of-date-palm-phoenix-dactylifera-l-based-on-a-yeast-functional-bioassay
#16
Himanshu V Patankar, Ibtisam Al-Harrasi, Rashid Al-Yahyai, Mahmoud W Yaish
Although date palm is a relatively salt-tolerant plant, the molecular basis of this tolerance is complex and poorly understood. Therefore, this study aimed to identify the genes involved in salinity tolerance using a basic yeast functional bioassay. To achieve this, a date palm cDNA library was overexpressed in Saccharomyces cerevisiae cells. The expression levels of selected genes that make yeast cells tolerant to salt were subsequently validated in the leaf and root tissues of date palm seedlings using a quantitative PCR method...
March 29, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29578049/the-acute-stresses-role-of-the-atypical-2-cys-peroxiredoxin-pmprx5-in-black-tiger-shrimp-penaeus-monodon-from-biological-immunity-and-environmental-toxicity-stress
#17
Ruiqian Bu, Lulu Yan, Chao Zhao, Pengfei Wang, Sigang Fan, Shu Wang, Lihua Qiu
As a unique atypical 2-Cys Peroxiredoxin (Prx) of the Prx-like superfamily, Peroxiredoxin5 (Prx5) possesses special properties, such as its enzymatic mechanism, wide subcellular distribution and high affinity for peroxides and peroxynitrite. Prx5 plays a crucial role in oxidative stress, immune responses, cell apoptosis, proliferation, differentiation, intracellular signaling, the modulation of gene expression, ecdysis, etc. In this paper, we obtained a full-length Prx5 cDNA sequence (designated PmPrx5) from black tiger shrimp (P...
March 22, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29576393/peroxiredoxins-are-important-for-the-regulation-of-hydrogen-peroxide-concentrations-in-ticks-and-tick-cell-line
#18
Kodai Kusakisako, Emmanuel Pacia Hernandez, Melbourne Rio Talactac, Kentaro Yoshii, Rika Umemiya-Shirafuji, Kozo Fujisaki, Tetsuya Tanaka
Ticks are obligate hematophagous ectoparasites, as they need to feed blood from vertebrate hosts for development. Host blood contains high levels of iron. Host-derived iron may lead to high levels of reactive oxygen species (ROS), including hydrogen peroxide (H2 O2 ). Since a high concentration of H2 O2 causes serious damage to organisms, this molecule is known to be a harmful chemical compound for aerobic organisms. On the other hand, the transparent method is compatible with chemical fluorescent probes. Therefore, we tried to establish the visualizing method for H2 O2 in unfed tick tissues...
March 17, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29574296/novel-prodrug-prx-p4-003-selectively-activated-by-gut-enzymes-may-reduce-the-risk-of-iatrogenic-addiction-and-abuse
#19
Sandeep T Patil, Ron H Bihovsky, Steven A Smith, William Z Potter, Valentino J Stella
OBJECTIVES: Prescription stimulants are vulnerable to oral and parenteral abuse. Intravenous forms of abuse may be most detrimental due to an enhanced risk of dependence, overdose, and infectious diseases. Our objective was to discover an orally active prodrug of a stimulant that would not be easily converted to its parent when injected, thus hindering intravenous abuse. METHODS: Following an initial analysis of stimulant structures, the fencamfamine isomer [(-)-FCF; (N-ethyl-3-phenylbicyclo[2...
March 2, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29567405/phylogenetic-analysis-of-cnidarian-peroxiredoxins-and-stress-responsive-expression-in-the-estuarine-sea-anemone-nematostella-vectensis
#20
Rebecca R Helm, Maria Laura Martín-Díaz, Ann M Tarrant
Peroxiredoxins (PRXs) are a family of antioxidant enzymes present in all domains of life. To date, the diversity and function of peroxiredoxins within animals has only been studied in a few model species. Thus, we sought to characterize peroxiredoxin diversity in cnidarians and to gain insight into their function in one cnidarian-the sea anemone Nematostella vectensis. Phylogenetic analysis using all six known PRX subfamilies (PRX1-4, PRX5, PRX6, PRXQ/AHPE1, TPX, BCP-PRXQ) revealed that like bilaterians, cnidarians contain representatives from three subfamilies (PRX1-4, PRX5, PRX6)...
March 19, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
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