Helena Castro, Maria Inês Rocha, Margarida Duarte, Jordi Vilurbina, Ana Georgina Gomes-Alves, Teresa Leao, Filipa Dias, Bruce Morgan, Marcel Deponte, Ana Maria Tomás
Typical two-cysteine peroxiredoxins (2-Cys-PRXs) are H2 O2 -metabolizing enzymes whose activity relies on two cysteine residues. Protists of the family Trypanosomatidae invariably express one cytosolic 2-Cys-PRX (cPRX1). However, the Leishmaniinae sub-family features an additional isoform (cPRX2), almost identical to cPRX1, except for the lack of an elongated C-terminus with a Tyr-Phe (YF) motif. Previously, cytosolic PRXs were considered vital components of the trypanosomatid antioxidant machinery. Here, we shed new light on the properties, functions and relevance of cPRXs from the human pathogen Leishmania infantum...
March 10, 2024: Redox Biology