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https://www.readbyqxmd.com/read/27933712/the-importance-of-mrna-structure-in-determining-the-pathogenicity-of-synonymous-and-non-synonymous-mutations-in-haemophilia
#1
N Hamasaki-Katagiri, B C Lin, J Simon, R C Hunt, T Schiller, E Russek-Cohen, A A Komar, H Bar, C Kimchi-Sarfaty
INTRODUCTION: Mutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype-phenotype relationships. Haemophilia is associated with inversions, deletions, insertions, nonsense and missense mutations. Both synonymous and non-synonymous mutations influence the base pairing of messenger RNA (mRNA), which can alter mRNA structure, cellular half-life and ribosome processivity/elongation...
December 9, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27933532/precise-network-modeling-of-systems-genetics-data-using-the-bayesian-network-webserver
#2
Jesse D Ziebarth, Yan Cui
The Bayesian Network Webserver (BNW, http://compbio.uthsc.edu/BNW ) is an integrated platform for Bayesian network modeling of biological datasets. It provides a web-based network modeling environment that seamlessly integrates advanced algorithms for probabilistic causal modeling and reasoning with Bayesian networks. BNW is designed for precise modeling of relatively small networks that contain less than 20 nodes. The structure learning algorithms used by BNW guarantee the discovery of the best (most probable) network structure given the data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933484/dna-as-a-target-for-anticancer-phen-imidazole-pd-ii-complexes
#3
Maryam Heydari, Mahboube Eslami Moghadam, AliAkbar Tarlani, Hossein Farhangian
Imidazole ring is a known structure in many natural or synthetic drug molecules and its metal complexes can interact with DNA and do the cleavage. Hence, to study the influence of the structure and size of the ligand on biological behavior of metal complexes, two water-soluble Pd(II) complexes of phen and FIP ligands (where phen is 1,10-phenanthroline and FIP is 2-(Furan-2-yl)-1H-Imidazo[4,5-f][1, 10]phenanthroline) with the formula of [Pd(phen)(FIP)](NO3)2 and [Pd(FIP)2]Cl2, that were activated against chronic myelogenous leukemia cell line, K562, were selected...
December 8, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27933430/structural-dynamics-of-nucleosome-mediated-by-acetylations-at-h3k56-and-h3k115-122
#4
Muthukumaran Rajagopalan, Sangeetha Balasubramanian, Ilya Ioshikhes, Amutha Ramaswamy
Post translational modifications have a profound role in the regulation of several biological processes such as transcription, replication, and DNA repair. Acetylation and phosphorylation form a major class of post translational modifications involved in nucleosomal regulation by modifying its structure. The effect of post translational modifications on nucleosome structure could be better explored when the molecular trajectories explaining the time dependent structural evolution over a period of time is examined at the atomic level...
December 8, 2016: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/27933168/thermal-ecological-physiology-of-native-and-invasive-frog-species-do-invaders-perform-better
#5
Pablo A Cortes, Hans Puschel, Paz Acuña, José L Bartheld, Francisco Bozinovic
Biological invasions are recognized as an important biotic component of global change that threatens the composition, structure and functioning of ecosystems, resulting in loss of biodiversity and displacement of native species. Although ecological characteristics facilitating the establishment and spread of non-native species are widely recognized, little is known about organismal attributes underlying invasion success. In this study, we tested the effect of thermal acclimation on thermal tolerance and locomotor performance in the invasive Xenopus laevis and the Chilean native Calyptocephalella gayi...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27933023/implicit-motives-and-men-s-perceived-constraint-in-fatherhood
#6
Jessica Ruppen, Patricia Waldvogel, Ulrike Ehlert
Research shows that implicit motives influence social relationships. However, little is known about their role in fatherhood and, particularly, how men experience their paternal role. Therefore, this study examined the association of implicit motives and fathers' perceived constraint due to fatherhood. Furthermore, we explored their relation to fathers' life satisfaction. Participants were fathers with biological children (N = 276). They were asked to write picture stories, which were then coded for implicit affiliation and power motives...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932909/cigesmed-for-divers-establishing-a-citizen-science-initiative-for-the-mapping-and-monitoring-of-coralligenous-assemblages-in-the-mediterranean-sea
#7
Vasilis Gerovasileiou, Thanos Dailianis, Emmanouela Panteri, Nikitas Michalakis, Giulia Gatti, Maria Sini, Charalampos Dimitriadis, Yiannis Issaris, Maria Salomidi, Irene Filiopoulou, Alper Doğan, Laure Thierry de Ville d'Avray, Romain David, Melih Ertan Ҫinar, Drosos Koutsoubas, Jean-Pierre Féral, Christos Arvanitidis
BACKGROUND: Over the last decade, inventorying and monitoring of marine biodiversity has significantly benefited from the active engagement of volunteers. Although several Citizen Science projects concern tropical reef ecosystems worldwide, none of the existing initiatives has yet specifically focused on their Mediterranean equivalents. Mediterranean coralline reefs, known as "coralligenous", are bioherms primarily built by calcifying rhodophytes on hard substrates under dim-light conditions; they are considered hotspots of biodiversity and are extremely popular among divers due to their complex structure, conspicuous biological wealth and high aesthetic value...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932867/clustering-algorithms-their-application-to-gene-expression-data
#8
REVIEW
Jelili Oyelade, Itunuoluwa Isewon, Funke Oladipupo, Olufemi Aromolaran, Efosa Uwoghiren, Faridah Ameh, Moses Achas, Ezekiel Adebiyi
Gene expression data hide vital information required to understand the biological process that takes place in a particular organism in relation to its environment. Deciphering the hidden patterns in gene expression data proffers a prodigious preference to strengthen the understanding of functional genomics. The complexity of biological networks and the volume of genes present increase the challenges of comprehending and interpretation of the resulting mass of data, which consists of millions of measurements; these data also inhibit vagueness, imprecision, and noise...
2016: Bioinformatics and Biology Insights
https://www.readbyqxmd.com/read/27932701/synthesis-and-characterization-of-fluorescein-grafted-polyurethane-for-potential-application-in-biomedical-tracing
#9
Boyuan Yang, Qin Zou, Lili Lin, Limei Li, Yi Zuo, Yubao Li
Redesigned multifunctional biopolymers represent a novel building bridge for interdisciplinary collaborations in biomaterials development. We prepared fluorescein-grafted polyurethane scaffolds (PU-C1, PU-C5, and PU-B1) to meet both clinical needs and biological safety evaluations, using different contents of calcein and different synthesis procedures for potential biomedical tracing. X-ray diffraction, infrared, X-ray photoelectron spectroscopy, nuclear magnetic resonance, scanning electron microscopy, and light microscopy were used to analyze the composition and structure of polyurethanes, as well as to observe their morphology with and without biomarkers...
December 8, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27932585/structural-and-functional-characterization-of-the-tyw3-taw3-class-of-sam-dependent-methyltransferases
#10
Mark A Currie, Greg Brown, Andrew Wong, Takayuki Ohira, Kei Sugiyama, Tsutomu Suzuki, Alexander F Yakunin, Zongchao Jia
S-adenosylmethionine (SAM)-dependent methyltransferases regulate a wide range of biological processes through the modification of proteins, nucleic acids, polysaccharides, as well as various metabolites. TYW3/Taw3 is a SAM-dependent methyltransferase responsible for the formation of a tRNA modification known as wybutosine and its derivatives that are required for accurate decoding in protein synthesis. Here, we report the crystal structure of Taw3, a homolog of TYW3 from Sulfolobus solfataricus, which revealed a novel α/β fold...
December 8, 2016: RNA
https://www.readbyqxmd.com/read/27932526/human-plasma-n-glycosylation-as-analyzed-by-maldi-fticr-ms-associates-with-markers-of-inflammation-and-metabolic-health
#11
Karli R Reiding, L Renee Ruhaak, Hae-Won Uh, Said El Bouhaddani, Erik B van den Akker, Rosina Plomp, Liam A McDonnell, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Manfred Wuhrer
Glycosylation is an abundant co- and post-translational protein modification of importance to protein processing and activity. While not template-defined, glycosylation does reflect the biological state of an organism and is a high-potential biomarker for disease and patient stratification. However, to interpret a complex but informative sample like the total plasma N-glycome (TPNG), it is important to establish its baseline association with plasma protein levels and systemic processes. Thus far, large scale studies (n > 200) of the TPNG have been performed with methods of chromatographic and electrophoretic separation, which, while being informative, are limited in resolving the structural complexity of plasma N-glycans...
December 8, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27932458/the-impact-of-recent-improvements-in-cryo-electron-microscopy-technology-on-the-understanding-of-bacterial-ribosome-assembly
#12
Aida Razi, Robert A Britton, Joaquin Ortega
Cryo-electron microscopy (cryo-EM) had played a central role in the study of ribosome structure and the process of translation in bacteria since the development of this technique in the mid 1980s. Until recently cryo-EM structures were limited to ∼10 Å in the best cases. However, the recent advent of direct electron detectors has greatly improved the resolution of cryo-EM structures to the point where atomic resolution is now achievable. This improved resolution will allow cryo-EM to make groundbreaking contributions in essential aspects of ribosome biology, including the assembly process...
December 8, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27932294/large-scale-structure-based-prediction-and-identification-of-novel-protease-substrates-using-computational-protein-design
#13
Manasi A Pethe, Aliza B Rubenstein, Sagar D Khare
Characterizing the substrate specificity of protease enzymes is critical for illuminating the molecular basis of their diverse and complex roles in a wide array of biological processes. Rapid and accurate prediction of their extended substrate specificity would also aid in the design of custom proteases capable of selectively and controllably cleaving biotechnologically or therapeutically relevant targets. However, current in silico approaches for protease specificity prediction, rely on, and are therefore limited by, machine learning of sequence patterns in known experimental data...
December 5, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27932258/heteroglycan-of-an-edible-mushroom-pleurotus-cystidiosus-structural-characterization-and-study-of-biological-activities
#14
Bibhash C Panda, Prasenjit Maity, Ashis K Nandi, Manabendra Pattanayak, Dilip K Manna, Soumitra Mondal, Satyajit Tripathy, Somenath Roy, Krishnendu Acharya, Syed S Islam
A water soluble heteroglycan (PCPS) was isolated from the aqueous extract of an edible mushroom Pleurotus cystidiosus. Structural characterization of the heteroglycan was carried out using total hydrolysis, methylation analysis, periodate oxidation, Smith degradation, and 1D/2D NMR experiments. Sugar analysis indicated the presence of glucose, galactose, and mannose in a molar ratio of nearly 6:2:1 respectively. The chemical and NMR analysis of the PCPS indicated the presence of a repeating unit with a backbone consisting of one unit of (1→6)-b-D-glucopyranosyl, two (1→3)-b-D-glucopyranosyl, one (1→3)-a-D-glucopyranosyl, one (1→6)-a-D-glucopyranosyl, and two (1→6)-a-D-galactopyranosyl moieties respectively, out of which one (1→3)-b-D-glucopyranosyl residue was branched at O-6 with terminal b-D-glucopyranosyl and another (1→6)-a-D-galactopyranosyl residue was branched at O-2 with terminal b-D-mannopyranosyl moiety...
December 5, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27931677/assuming-the-role-of-mitochondria-in-mycobacterial-infection
#15
REVIEW
Rikesh K Dubey
Tuberculosis is one of the leading causes of death by Mycobacterium tuberculosis (Mtb) affecting millions of people worldwide. Mycobacterium species enter host macrophages during infection and target various cellular organelles and their function for their own benefit. Mitochondria appear to be among the important targets for bacterial pathogens. Mtb and other pathogenic bacteria secrete various proteins that initiate structural changes in mitochondria to modulate its function. Additionally, virulent mycobacteria interfere with the balance between pro- and anti-apoptotic factors to inhibit apoptosis and, in later stages, promote necrosis...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931609/clinical-and-biological-insights-into-combined-post-and-pre-capillary-pulmonary-hypertension
#16
Tufik R Assad, Anna R Hemnes, Emma K Larkin, Andrew M Glazer, Meng Xu, Quinn S Wells, Eric H Farber-Eger, Quanhu Sheng, Yu Shyr, Frank E Harrell, John H Newman, Evan L Brittain
BACKGROUND: Pulmonary hypertension (PH) is a common and morbid complication of left heart disease with 2 subtypes: isolated post-capillary pulmonary hypertension (Ipc-PH) and combined post-capillary and pre-capillary pulmonary hypertension (Cpc-PH). Little is known about the clinical or physiological characteristics that distinguish these 2 subphenotypes or if Cpc-PH shares molecular similarities to pulmonary arterial hypertension (PAH). OBJECTIVES: The goal of this study was to test the hypothesis that the hemodynamic and genetic profile of Cpc-PH would more closely resemble PAH than Ipc-PH...
December 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27931113/a-new-naphthalenepropanoic-acid-analog-from-the-marine-derived-actinomycetes-micromonospora-sp-hs-hm-036
#17
Mei-Yue Gao, Huan Qi, Jian-Song Li, Hui Zhang, Ji Zhang, Ji-Dong Wang, Wen-Sheng Xiang
A new naphthalenepropanoic acid analog (1) was isolated from the broth of the actinomycetes Micromonospora sp. HS-HM-036. The structure of compound 1 was determined based on MS and extensive NMR analysis. A preliminary investigation of the biological activity of compound 1 was also described.
December 9, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27930902/a-large-scale-national-study-of-gambling-severity-among-immigrant-and-non-immigrant-adolescents-the-role-of-the-family
#18
Natale Canale, Alessio Vieno, Mark D Griffiths, Alberto Borraccino, Giacomo Lazzeri, Lorena Charrier, Patrizia Lemma, Paola Dalmasso, Massimo Santinello
AIM: The primary aim of the present study was to examine the association between immigrant generation, family sociodemographic characteristics, and problem gambling severity in a large-scale nationally representative sample of Italian youth. METHOD: Data from the 2013-2014 Health Behaviour in School-aged Children (HBSC) Survey were used for cross-sectional analyses of adolescent problem gambling. Self-administered questionnaires were completed by a representative sample of 20,791 15-year-old students...
November 24, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27930868/laser-surface-pattering-of-titanium-for-improving-the-biological-performance-of-dental-implants
#19
Christoph Zwahr, Denise Günther, Tina Brinkmann, Nikolai Gulow, Steffen Oswald, Marzellus Grosse Holthaus, Andrés Fabián Lasagni
Direct laser interference patterning (DLIP) is used to produce periodic line-like patterns on titanium surfaces. An Nd:YAG laser operating at 532 nm wavelength with a pulse duration of 8 ns is used for the laser patterning process. The generated periodic patterns with spatial periods of 5, 10, and 20 µm are produced with energy densities between 0.44 and 2.6 J cm(-)(2) with a single laser pulse. With variation of energy density, different shapes of the arising topography are observed due to the development of the solidification front of the molten material at the maxima positions...
December 8, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27930818/pyridine-nucleotide-transhydrogenase-pntab-is-essential-for-optimal-growth-and-photosynthetic-integrity-under-low-light-mixotrophic-conditions-in-synechocystis-sp-pcc-6803
#20
Jari Kämäräinen, Tuomas Huokko, Sanna Kreula, Patrik R Jones, Eva-Mari Aro, Pauli Kallio
Pyridine nucleotide transhydrogenase (PntAB) is an integral membrane protein complex participating in the regulation of NAD(P)(+) :NAD(P)H redox homeostasis in various prokaryotic and eukaryotic organisms. In the present study we addressed the function and biological role of PntAB in oxygenic photosynthetic cyanobacteria capable of both autotrophic and heterotrophic growth, with support from structural three-dimensional (3D)-modeling. The pntA gene encoding the α subunit of heteromultimeric PntAB in Synechocystis sp...
December 8, 2016: New Phytologist
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