Maryam Mohsin, Hafiz Zeyad, Hareem Khalid, Abubakar Gapizov, Ruqiya Bibi, Yashkumar Girdharlal Kamani, Ahmed Rashid, Muhammad Shams, Faizan Khalid, Syeda Khan, Muhammad Waqas, Anzal Ishfaq, Ayele H Kebede, Muhammad Subhan
Type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF) are widespread chronic conditions that profoundly impact public health. While the intricate mechanisms linking these two diseases remain incompletely understood, this review sets out to comprehensively analyze the current evidence about their pathophysiology, epidemiology, diagnosis, prognosis, and treatment. We reveal that T2DM can influence the electrical and structural properties of the atria through multiple pathways, including oxidative stress, inflammation, fibrosis, connexin remodeling, glycemic variability, and autonomic dysfunction...
September 2023: Curēus