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heart failure and diet

Madeline R Sterling, Ariel F Silva, Laura Robbins, Savira K Dargar, Marilyn M Schapira, Monika M Safford
OBJECTIVE: To examine the perspectives of adults with heart failure (HF) about numerical concepts integral to HF self-care. SETTING: This qualitative study took place at an urban academic primary care practice. PARTICIPANTS: Thirty men and women aged 47-89 years with a history of HF were recruited to participate. Eligibility criteria included: a history of HF (≥1 year), seen at the clinic within the last year, and a HF hospitalisation within the last 6 months...
September 19, 2018: BMJ Open
Fen Gong, Junfei Gu, Haijun Wang
The prevalence of cardiomyopathy due to metabolic stress has up-regulated dramatically; nevertheless, its molecular mechanisms remain unclear. Here we suggested that transmembrane BAX inhibitor motif-containing 1 (Tmbim1) is down-regulated in the hearts of mice fed with high fat diet (HFD). We provided evidence that Tmbim1 knockout (KO) accelerated HFD-induced metabolic disorders in mice, as supported by the remarkable increase of fasting serum glucose and insulin levels. HFD-induced cardiac dysfunctions were greatly intensified by the loss of Tmbim1, along with higher levels of lactate dehydrogenase (LDH) and creatine kinase (CK) in serum...
September 11, 2018: Biochemical and Biophysical Research Communications
Jia-Rong Wu, Eun Kyeung Song, Debra K Moser, Terry A Lennie
BACKGROUND: Vitamin C deficiency is prevalent in adults with heart failure (HF). Little is known about the relationship of dietary vitamin C deficiency with health outcomes in adults with HF. OBJECTIVE: The study's aim was to determine the relationships of vitamin C deficiency measured at baseline with health-related quality of life (HRQOL) and cardiac event-free survival in patients with HF measured 1 year later. METHOD: A total of 251 patients with HF completed a 4-day food diary...
September 11, 2018: Journal of Cardiovascular Nursing
Veronica Bonderski, Daniel G Morrow, Jessie Chin, Michael D Murray
Heart failure is a chronic disease requiring careful attention to self-care. Patients must follow instructions for diet and medication use to prevent or delay a decline in functional status, quality of life, and expensive care. However, there is considerable heterogeneity in heart failure patients' knowledge of important care routines, their cognition, and their health literacy, which predict the ability to implement self-care. Our interdisciplinary team of cognitive scientists with health literacy expertise, pharmacists, and physicians spent 18 years designing and testing protocols and materials to assist ambulatory heart failure patients with their care...
September 6, 2018: Drugs & Aging
Michail M Padrul, Anna A Olina, Gulnara K Sadykova
Wilson-Konovalov's disease (DWK) is a polysyndrome hereditary disease associated with excessive accumulation of copper due to the delay in its removal from the body. The condition of the reproductive system in patients with DWK is not well understood. It is proved that copper is a microelement necessary for the synthesis of estrogens, the secretion of prostaglandins in the endometrium. According to the results of the study, in reproductive age patients with DWK who do not receive adequate therapy, the reproductive function is impaired...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Jenica N Upshaw
Patients with breast cancer have higher rates of cardiovascular disease than age-matched controls. Anthracyclines and trastuzumab increase the risk of heart failure (HF) and radiation increases the risk of ischemic heart disease, valvular disease and HF. Older age, low normal ejection fraction, history of coronary artery disease (CAD), cardiac risk factors, higher cumulative anthracycline exposure, combination anthracycline and trastuzumab and/or radiation all increase the risk of cardiac events post treatment...
August 2018: Gland Surgery
Dan Chen, Xia Li, LiTing Zhang, Mei Zhu, Ling Gao
A high-fat diet (HFD) has been associated with heart failure and arrhythmias; however, the molecular mechanisms underlying these associations are poorly understood. The mitochondria play an essential role in optimal heart performance, most of the energy for which is obtained from the oxidation of fatty acids. As such, chronic exposure to excess fatty acids may cause mitochondrial dysfunction and heart failure. To investigate the effects of a HFD on the mitochondrial function in the myocardium, 40 male rats were randomly divided into two groups and fed with either a normal diet or a HFD for 28 weeks...
September 1, 2018: Journal of Cellular Biochemistry
Olga Tsoref, Dalia Tyomkin, Uri Amit, Natalie Landa, Osnat Cohen-Rosenboim, David Kain, Moran Golan, Nili Naftali-Shani, Ayelet David, Jonathan Leor
Endothelial activation with up-regulation of E-selectin adhesion molecules mediates leukocyte rolling along the vascular wall and controls inflammation in many diseases including atherosclerosis and heart failure. Therefore, we aimed to test the hypothesis that inhibition of E-selectin-mediated interactions by a new E-selectin-targeted copolymer could inhibit the progression of atherosclerosis. To target E-selectin on activated endothelium, we developed a new N-(2-hydroxypropyl)methacrylamide (HPMA)-based E-selectin binding copolymer with or without dexamethasone (Dex) (designated P-(Esbp)-Dex and P-Esbp, respectively)...
August 27, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Sukka Santosh Reddy, Heena Agarwal, Manoj Kumar Barthwal
Cilostazol (Ciloz) a potent Type III phosphodiesterase inhibitor is effective against inflammation, insulin resistance and cardiomyopathy. However, the effect of Ciloz on obesity-associated left ventricular diastolic dysfunction has not been explored yet. Hence, we examined the effect of Ciloz on cardiac remodelling and dysfunction in non-obese and obese-insulin resistant mice infused with AngiotensinII (AngII). Male C57BL/6 J mice were initially subjected to 19 weeks of chow or high fat diet (HFD) regimen and thereafter animals were randomised for AngII (1500 ng/kg/min, s...
August 20, 2018: Journal of Molecular and Cellular Cardiology
Natasha Fillmore, Jody L Levasseur, Arata Fukushima, Cory S Wagg, Wei Wang, Jason R B Dyck, Gary D Lopaschuk
BACKGROUND: Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve. However, despite the high prevalence of HF with preserved ejection fraction (HFpEF) in our society, it is not clear what changes in cardiac energy metabolism occur in HFpEF, and whether alterations in energy metabolism contribute to the development of contractile dysfunction...
March 15, 2018: Molecular Medicine
Levi W Evans, Bradley S Ferguson
Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF...
August 18, 2018: Nutrients
Conor P Kerley
Growing evidence has emerged about the role of dietary patterns and components in heart failure (HF) incidence and severity. The objective here is to provide a comprehensive summary of the current evidence regarding dietary patterns/components and HF. A comprehensive search of online databases was conducted using multiple relevant keywords to identify relevant human studies. The Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diets have consistently been associated with decreased HF incidence and severity...
August 16, 2018: Nutrition Research Reviews
Yogi Umbarawan, Mas Rizky A A Syamsunarno, Norimichi Koitabashi, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Motoaki Sano, Hiroaki Sunaga, Hiroki Matsui, Yoshito Tsushima, Makoto Suematsu, Masahiko Kurabayashi, Tatsuya Iso
The energy metabolism of the failing heart is characterized by reduced fatty acid (FA) oxidation and an increase in glucose utilization. However, little is known about how energy metabolism-function relationship is relevant to pathophysiology of heart failure. Recent study showed that the genetic deletion of CD36 (CD36KO), which causes reduction in FA use with an increased reliance on glucose, accelerates the progression from compensated hypertrophy to heart failure. Here, we show the mechanisms by which CD36 deletion accelerates heart failure in response to pressure overload...
August 13, 2018: Scientific Reports
Ana Luiza Teixeira Dos Santos, Camila Kummel Duarte, Manoella Santos, Maira Zoldan, Jussara Carnevalle Almeida, Jorge Luiz Gross, Mirela Jobim Azevedo, Alice Hinda Lichtenstein, Themis Zelmanovitz
AIM: This cross-sectional study aimed to assess the association of the fat content in the diet with Diabetic Kidney Disease (DKD) in patients with type 2 diabetes. METHODOLOGY: Patients from the Diabetes research clinic at Hospital de Clínicas de Porto Alegre (Brazil) were consecutively recruited. The inclusion criterion was the diagnosis of type 2 diabetes. The exclusion criteria were as follows: body mass index >40 kg/m2, heart failure, gastroparesis, diabetic diarrhea, dietary counseling by a registered dietitian during the previous 12 months, and inability to perform the weighed diet records (WDR)...
2018: PloS One
A G Obrezan, N V Kulikov
In this article we present data of scientific studies of prevalence of diabetes mellitus (DM) among patients with chronic heart failure (CHF), pathogenetic and risk factors of CHF development patients with DM (hyperglycemia, elevated body mass index, age, ischemic heart disease, nephropathy, proteinuria, DM duration, etc.). The article also contains results of analysis of mortality of patients with and without DM in dependence of ejection fraction value. After characterization of drugs for treatment of CHF in general and specifically in patients with DM we make focus on perspective directions in treatment of this group of patients...
July 2018: Kardiologiia
Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G Abraham, Michael Arad, Edith Hochhauser
BACKGROUND: Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and fibrosis, both of which are aggravated by angiotensin. Caloric restriction (CR) is cardioprotective in animal models of heart disease through its catabolic activity and activation of the expression of adaptive genes...
August 2, 2018: Cardiovascular Diabetology
Mahsa Hasanzadeh-Moghadam, Mohammad Hassan Khadem-Ansari, Gholam Hossein Farjah, Yousef Rasmi
Myocardial infarction is commonly considered as a leading cause of cardiovascular disease taking the lives of seven million people annually. Liver dysfunction is associated with cardiac diseases. The profile of abnormal liver functions in heart failure is not clearly defined. This study was designed to investigate the protective effects of betaine on liver injury after myocardial infarction induced by isoprenaline in rats. Forty-eight male rats were divided into four groups: the control group received normal diet and the experimental groups received 50, 150, and 250 mg kg-1 body weight of betaine daily through gastric gavages for 60 days...
2018: Veterinary Research Forum
Salvatore Carbone, Justin M Canada, Leo F Buckley, Cory R Trankle, Hayley E Billingsley, Dave L Dixon, Adolfo G Mauro, Sofanit Dessie, Dinesh Kadariya, Eleonora Mezzaroma, Raffaella Buzzetti, Ross Arena, Benjamin W Van Tassell, Stefano Toldo, Antonio Abbate
Heart failure with preserved ejection fraction (HFpEF) is associated with obesity and, indirectly, with unhealthy diet. The role of dietary components in HFpEF is, however, largely unknown. In this study, the authors showed that in obese HFpEF patients, consumption of unsaturated fatty acids (UFA), was associated with better cardiorespiratory fitness, and UFA consumption correlated with better diastolic function and with greater fat-free mass. Similarly, mice fed with a high-fat diet rich in UFA and low in sugars had preserved myocardial function and reduced weight gain...
October 2017: JACC. Basic to Translational Science
Nelson Andrade, Elisabete Alves, Ana Rute Costa, Pedro Moura-Ferreira, Ana Azevedo, Nuno Lunet
OBJECTIVES: To characterize specific knowledge on cardiovascular disease, particularly stroke and myocardial infarction (MI), and its relationship with sociodemographic factors, health literacy and clinical history, among the Portuguese population. METHODS: In a cross-sectional study conducted in 2012, a total of 1624 Portuguese-speaking residents of mainland Portugal, aged between 16 and 79 years, were assessed through face-to-face interviews using a structured questionnaire...
August 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
K McDowell, M C Petrie, N A Raihan, J Logue
OBJECTIVE: Obesity is an independent risk factor for the development of heart failure, and the two commonly co-exist. The European Society of Cardiology does not provide guidance regarding weight loss strategies in heart failure. The aim of this study was to systematically review the evidence for outcomes following intentional weight loss in patients with heart failure and obesity. METHOD: A systematic review of English articles was undertaken using databases PubMed, Embase and CENTRAL...
September 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
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