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heart failure and diet

Emmanouil G Spanakis, Maria Psaraki, Vangelis Sakkalis
Congestive heart failure (CHF) occurs when the heart cannot provide the necessary cardiac output for the metabolic needs of the human body. The most prominent symptoms are increased venous pressure, abnormal heart and breathing rate, tiredness and leg swelling. Most important pathogenesis influence are: age, gender, high blood pressure, alcohol and smoking, sedentary lifestyle and diet, genetic predisposition and family history, diabetes, and atherosclerosis. Common causes are considered to be valvular heart disease, coronary heart disease and hypertension...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Keke Wang, Chao Chu, Jiawen Hu, Yang Wang, Wenling Zheng, Yongbo Lv, Yu Yan, Qiong Ma, Jianjun Mu
BACKGROUND: Dietary sodium affects fluctuations in blood pressure (BP) and vascular function. Cardiotrophin-1 (CT-1), a stress-induced cytokine that belongs to the interleukin 6 family, is released by cells in response to potentially harmful stresses and plays a pivotal role in congestive heart failure, hypertension and arterial stiffness. In this study, we performed a randomized trial to confirm the effects of altered salt intake on the serum CT-1 levels in humans. METHODS: Forty-four subjects (18-65 years of age) were selected from a rural community in northern China...
November 8, 2018: Annals of Nutrition & Metabolism
Bruno Igreja, Nuno M Pires, Lyndon C Wright, Patrício Soares-da-Silva
Hyperactivity of sympathetic nervous system plays an important role in the development and progression of cardiovascular diseases. An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine β-hydroxylase (DβH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves. The aim of the present study was to evaluate the effects of zamicastat, a novel DβH inhibitor that decreases noradrenaline and increases dopamine levels in peripheral sympathetically innervated tissues, on the hemodynamic and cardiometabolic parameters in salt-induced hypertension and heart failure in the Dahl salt-sensitive (SS) rat...
October 26, 2018: European Journal of Pharmacology
Liping Zhou, Adrian Filiberti, Mary Beth Humphrey, Christian D Fleming, Benjamin J Scherlag, Sunny S Po, Stavros Stavrakis
NEW FINDINGS: What is the central question of this study? In this study, we investigated the effect of chronic intermittent low-level transcutaneous vagus nerve stimulation on cardiac inflammation, fibrosis and diastolic dysfunction in a rat model of heart failure with preserved ejection fraction. What is the main finding and its importance? In salt-sensitive rats fed with high salt diet, we show that low-level transcutaneous vagus nerve stimulation significantly attenuates blood pressure elevation, ameliorates diastolic function and attenuates left ventricular inflammation and fibrosis compared to the sham group...
November 6, 2018: Experimental Physiology
E A Ostrakhovitch, S Tabibzadeh
There are numerous theories of aging, a process which still seems inevitable. Aging leads to cancer and multi-systemic disorders as well as chronic diseases including those that impair the functions of endothelial cells, kidney and lung. Decline in age- associated cellular functions leads to neurodegeneration and cognitive decline that affect the quality of life. Accumulation of damage, mutations, metabolic changes, failure in cellular energy production and clearance of altered proteins over the lifetime, and hyperhomocysteinemia, ultimately result in tissue degeneration...
November 1, 2018: Ageing Research Reviews
Nobutoshi Matsumura, Shingo Takahara, Zaid H Maayah, Nirmal Parajuli, Nikole J Byrne, Sherif M Shoieb, Carrie-Lynn M Soltys, Donna L Beker, Grant Masson, Ayman O S El-Kadi, Jason R B Dyck
Numerous epidemiological studies have demonstrated that approximately 40% of myocardial infarctions (MI) are associated with heart failure (HF). Resveratrol, a naturally occurring polyphenol, has been shown to be beneficial in the treatment of MI-induced HF in rodent models. However, the mechanism responsible for the effects of resveratrol are poorly understood. Interestingly, resveratrol is known to inhibit cytochrome P450 1B1 (CYP1B1) which is involved in the formation of cardiotoxic hydroxyeicosatetraenoic acid (HETE) metabolites...
October 28, 2018: Journal of Molecular and Cellular Cardiology
Mudit Mishra, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Herman Kempen, Bart De Geest
Heart failure with preserved ejection fraction (HFpEF) represents a major unmet therapeutic need. This study investigated whether feeding coconut oil (CC diet) for 26 weeks in female C57BL/6N mice induces HFpEF and evaluated the effect of reconstituted high-density lipoprotein (HDL)Milano (MDCO-216) administration on established HFpEF. Eight intraperitoneal injections of MDCO-216 (100 mg/kg protein concentration) or of an equivalent volume of control buffer were executed with a 48-h interval starting at 26 weeks after the initiation of the diet...
October 30, 2018: International Journal of Molecular Sciences
Terry A Lennie, Christina Andreae, Mary Kay Rayens, Eun Kyeung Song, Sandra B Dunbar, Susan J Pressler, Seongkum Heo, JinShil Kim, Debra K Moser
Background Dietary micronutrient deficiencies have been shown to predict event-free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart failure was associated with shorter event-free survival, defined as a combined end point of all-cause hospitalization and death. Methods and Results Four-day food diaries were collected from 246 patients with heart failure (age: 61...
September 4, 2018: Journal of the American Heart Association
Anand R Nair, Larry N Agbor, Masashi Mukohda, Xuebo Liu, Chunyan Hu, Jing Wu, Curt D Sigmund
Low-salt diet is beneficial in salt-sensitive hypertension but may provoke cardiovascular risk in patients with heart failure, diabetes mellitus, or other cardiovascular abnormalities because of endogenous renin-angiotensin system activation. PPAR (peroxisome proliferator-activated receptor)-γ is a transcription factor which promotes an antioxidant pathway in the endothelium. We studied transgenic mice expressing a dominant-negative mutation in PPAR-γ selectively in the endothelium (E-V290M) to test the hypothesis that endothelial PPAR-γ plays a protective role in response to low salt-mediated renin-angiotensin system activation...
November 2018: Hypertension
Scott L Hummel, Wahida Karmally, Brenda W Gillespie, Stephen Helmke, Sergio Teruya, Joanna Wells, Erika Trumble, Omar Jimenez, Cara Marolt, Jeffrey D Wessler, Maria L Cornellier, Mathew S Maurer
Background In patients with heart failure (HF), malnutrition and dietary sodium excess are common and may worsen outcomes. No prior studies have provided low-sodium, nutritionally complete meals following HF hospitalization. Methods and Results The GOURMET-HF study (Geriatric Out-of-Hospital Randomized Meal Trial in Heart Failure) randomized patients discharged from HF hospitalization to 4 weeks of home-delivered sodium-restricted Dietary Approaches to Stop Hypertension meals (DASH/SRD; 1500 mg sodium/d) versus usual care...
August 2018: Circulation. Heart Failure
Agnieszka Mlynarska, Krzysztof S Golba, Rafal Mlynarski
Background: A thorough analysis of the capability for self-care in patients with heart failure (HF) reduces the frequency of hospitalizations that are caused by decompensation. The aim of the study was to assess the effect of the method of therapy for HF, the degree of the acceptance of illness, and the occurrence of frailty syndrome on adherence to the therapeutic recommendations and self-care in patients with HF. Methods: The study included 180 patients who were hospitalized after being diagnosed with HF...
2018: Clinical Interventions in Aging
A Susana Ramírez, Kimberly Arellano Carmona
BACKGROUND: Fatalism - beliefs about the causes and controllability of disease - has been negatively associated with prevention behaviors. Fatalism has been suggested as a mechanism for health disparities because ethnic minorities are especially likely to hold fatalistic beliefs. However, the construct has been criticized: Fatalism fails to account for structural barriers to health faced by vulnerable populations that also score highly on measures of fatalism. Another critique suggests that operationalizations of fatalism expose communication failures: "Fatalism" rather reflects information overload from an environment riddled with misinformation and contradictions...
December 2018: Social Science & Medicine
John Berntsson, J Gustav Smith, Linda S B Johnson, Martin Söderholm, Yan Borné, Olle Melander, Marju Orho-Melander, Jan Nilsson, Gunnar Engström
OBJECTIVE: Vascular endothelial growth factor D (VEGF-D) has important functions in lymphangiogenesis and angiogenesis. High plasma levels of VEGF-D have been associated with incidence of heart failure. The association of VEGF-D with atrial fibrillation (AF) and stroke is unclear and we hypothesised that VEGF-D could also be associated with incidence of AF and ischaemic stroke. METHODS: VEGF-D was measured in fasting blood samples of 4689 subjects (40% men) without a history of AF from the Malmö Diet and Cancer Study, a prospective, population-based study in Sweden...
October 16, 2018: Heart: Official Journal of the British Cardiac Society
Vittorio Emanuele Bianchi
The metabolic sources of energy for myocardial contractility include mainly free fatty acids (FFA) for 95%, and in lesser amounts for 5% from glucose and minimal contributions from other substrates such lactate, ketones, and amino acids. However, myocardial efficiency is influenced by metabolic condition, overload, and ischemia. During cardiac stress, cardiomyocytes increase glucose oxidation and reduce FFA oxidation. In patients with ischemic coronary disease and heart failure, the low oxygen availability limits myocardial reliance on FFA and glucose utilization must increase...
September 11, 2018: Current Problems in Cardiology
Chrishan J Nalliah, Prashanthan Sanders, Jonathan M Kalman
PURPOSE OF REVIEW: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans, affecting more than 33 million people globally. Its association with complex, resource intensive medical conditions such as stroke, heart failure and dementia have had profound impacts across existing health care structures. The global prevalence of AF has enjoyed significant growth despite significant improvement in our armamentarium for arrhythmia treatment. RECENT FINDINGS: Efforts aimed at curtailing the incidence, prevalence, or progression of AF have prompted re-evaluation of traditional frameworks for understanding and managing this debilitating disease...
October 12, 2018: Current Cardiology Reports
D Thomas, F Paillard, J M Lecerf, F Carré
The behavioral goals of the coronary patient require active management by the cardiologist. Every smoker must be clearly informed about the cardiovascular consequences of smoking and the major benefits of smoking cessation. The only advice to "quit smoking" is not enough. Validated "treatments" (cognitive-behavioral therapy, nicotine replacement therapy, varenicline, bupropion) must be used, with a precise strategy and prolonged follow-up. All drugs assistance can be prescribed in coronary patients and nicotine replacement therapy can even be used just after a myocardial infarction...
October 9, 2018: Annales de Cardiologie et D'angéiologie
Josje D Schoufour, Jessica C Kiefte-de Jong, Trudy Voortman
OBJECTIVE: We aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. DESIGN: We studied 9,701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45 years and over. METHOD: Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200g/d), fruit (≥200g/d), whole-grains (≥90g/d), legumes (≥135g/wk), nuts (≥15g/d), dairy (≥350g/d), fish (≥100g/wk), tea (≥450mL/d), ratio whole-grains:total grains (≥50%), ratio unsaturated fats & oils:total fats (≥50%), red and processed meat (<300g/wk), sugar-containing beverages (<150mL/d), alcohol (<10 g/d) and salt (≤6g/d)...
September 19, 2018: Nederlands Tijdschrift Voor Geneeskunde
Etienne Audureau, Aziz Guellich, Esther Guéry, Florence Canouï-Poitrine, Véronique Benedyga, Hélène Duchossoir, Charles Taieb, Thibaud Damy
(1) Background: Burden scales are useful in estimating the impact of interventions from patients' perspectives. This is overlooked in sodium diet/heart failure (HF). The aim of this study is to develop and validate a specific tool to assess the burden associated with low-sodium diets in HF: the Burden scale In Restricted Diets (BIRD). (2) Methods: Based on the literature and reports from patients, 14 candidate items were identified for the following dietary-related domains: organization, pleasure, leisure, social life, vitality, and self-rated health...
October 7, 2018: Nutrients
Sara B Seidelmann, Elena Feofanova, Bing Yu, Nora Franceschini, Brian Claggett, Mikko Kuokkanen, Hannu Puolijoki, Tapani Ebeling, Markus Perola, Veikko Salomaa, Amil Shah, Josef Coresh, Elizabeth Selvin, Calum A MacRae, Susan Cheng, Eric Boerwinkle, Scott D Solomon
BACKGROUND: Loss-of-function mutations in the SGLT1 (sodium/glucose co-transporter-1) gene result in a rare glucose/galactose malabsorption disorder and neonatal death if untreated. In the general population, variants related to intestinal glucose absorption remain uncharacterized. OBJECTIVES: The goal of this study was to identify functional SGLT1 gene variants and characterize their clinical consequences. METHODS: Whole exome sequencing was performed in the ARIC (Atherosclerosis Risk in Communities) study participants enrolled from 4 U...
October 9, 2018: Journal of the American College of Cardiology
Sofia Bronzato, Alessandro Durante
The market of nutritional supplements is expected to expand over 6%/year through 2018 due to growing interest in personal health, aging population, and promising personalized care products. The most used dietary supplements are fish oil, multivitamins, Vitamin D, and coenzyme Q10 (CoQ10) in this order, while probiotics is the fastest growing supplement. In the U.S., over 68% of the population use dietary supplements regularly. On the other hand, in the developed countries, cardiovascular diseases (CVDs) are the main cause of death and morbidity from the 1900s...
2018: International Journal of Preventive Medicine
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