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https://www.readbyqxmd.com/read/28925476/late-onset-pompe-disease-in-a-54-year-old-sportsman-with-an-episode-of-syncope-a-case-report
#1
M Walczak-Galezewska, D Skrypnik, M Szulinska, K Musialik, K Skrypnik, P Bogdanski
Pompe disease is an extra-rare metabolic storage disease with deficiency of acid-alpha-glucosidase (GAA) enzyme activity, which leads to the pathologic accumulation of glycogen in target tissues (skeletal muscles, heart, brain). Clinical features and severity vary by the age of onset, rate of extent of organ involvement. In the late-onset Pompe disease (LOPD) form, essential cardiomyopathy seems to be uncommon. Muscles weakness and respiratory failure are the main symptoms of adult patient with Pompe disease...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28914660/mediterranean-diet-impact-on-cardiovascular-diseases-a-narrative-review
#2
Anna V Mattioli, Pasquale Palmiero, Olivia Manfrini, Paolo E Puddu, Savina Nodari, Alessandra Dei Cas, Giuseppe Mercuro, Domenico Scrutinio, Pietro Palermo, Susanna Sciomer, Simona Di Francesco, Giuseppina Novo, Salvatore Novo, Roberto F E Pedretti, Annapaola Zito, Gianfranco Parati, Roberto Pedrinelli, Alberto Farinetti, Maria Maiello, Federica Moscucci, Raffaele L Tenaglia, Vincenzo Sucato, Marco Triggiani, Lucia Cugusi, Pietro Scicchitano, Pier S Saba, Marco M Ciccone
: Cardiovascular disease (CVD) accounts for more than 17 million deaths per year worldwide. It has been estimated that the influence of lifestyle on CVD mortality amounts to 13.7% for smoking, 13.2% for poor diet, and 12% for inactive lifestyle. These results deeply impact both the healthy status of individuals and their skills in working. The impact of CVD on productivity loss accounts for the 24% in total costs for CVD management.Mediterranean diet (MedD) can positively impact on natural history of CVD. It is characterized by a relatively high consumption of inexpensive and genuine food such as cereals, vegetables, legumes, nuts, fish, fresh fruits, and olive oil as the principal source of fat, low meat consumption and low-to-moderate consumption of milk, dairy products, and wine...
September 12, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28888352/high-fat-diet-aggravates-atrial-and-ventricular-remodeling-of-hypertensive-heart-disease-in-aging-rats
#3
Yi-Lin Shiou, I-Chieh Huang, Hsin-Ting Lin, Hsiang-Chun Lee
BACKGROUND/PURPOSE: Left ventricular hypertrophy is a major cause of heart failure in aging population. This study is to determine whether an excess dietary fat is lipotoxic or lipoprotein to the hypertrophic aging heart. METHODS: At 44-week-old, a normal chow (12% fat) was replaced a high-fat diet (HFD; 45% fat) for randomly selective spontaneously hypertensive rats (SHR + HFD, n = 6) and Wistar-Kyoto rats (WKY + HFD, n = 6, normotensive control). Others (SHR, n = 11; WKY, n = 10) were continuously fed with normal diets...
September 6, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28883044/beneficial-effects-of-exercise-training-in-heart-failure-are-lost-in-male-diabetic-rats
#4
Dalila Boudia, Valérie Domergue, Phlippe Mateo, Loubina Fazal, Mathilde Prud'homme, Heloise Prigent, Claude Delcayre, Alain Cohen-Solal, Anne Garnier, Renee Ventura-Clapier, Jane-Lise Samuel
Exercise training has been demonstrated to have beneficial effects in patients with heart failure (HF) or diabetes. However, it is unknown whether diabetic patients with HF will benefit from exercise training. Male Wistar rats were fed either a standard (Sham, n= 53) or high-fat, high-sucrose (HFHS) diet (D, n=66) for 6 months. After 2 months of diet, the rats were already diabetic. Rats were then randomly subjected to either myocardial infarction by coronary artery ligation (MI) or sham operation (Sham). Two months later, heart failure was documented by echocardiography and animals were randomly subjected to exercise training with treadmill for eight additional weeks or remained sedentary...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28872781/armax-a-method-for-assessment-of-the-dynamic-response-of-the-arterial-baroreflex
#5
Morten T Lund, Max Salomonsson, Thomas E N Jonassen, Niels-Henrik Holstein-Rathlou
AIM: The baroreflex is a key mechanism in cardiovascular regulation and alterations in baroreceptor function are seen in many diseases, including heart failure, obesity and hypertension. We propose a new method for analyzing baroreceptor function from continuous blood pressure and heart rate in both health and disease. METHODS: 48-hour data series of blood pressure and heart rate were collected with telemetry. Sprague-Dawley rats on standard chow (n=11) served as controls, while rats on a high-fat, high-fructose diet (n=6) constituted the obese-hypertensive model...
September 5, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28864331/fruit-vegetable-and-legume-intake-and-cardiovascular-disease-and-deaths-in-18-countries-pure-a-prospective-cohort-study
#6
Victoria Miller, Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Xiaohe Zhang, Sumathi Swaminathan, Gilles Dagenais, Rajeev Gupta, Viswanathan Mohan, Scott Lear, Shrikant I Bangdiwala, Aletta E Schutte, Edelweiss Wentzel-Viljoen, Alvaro Avezum, Yuksel Altuntas, Khalid Yusoff, Noorhassim Ismail, Nasheeta Peer, Jephat Chifamba, Rafael Diaz, Omar Rahman, Noushin Mohammadifard, Fernando Lana, Katarzyna Zatonska, Andreas Wielgosz, Afzalhussein Yusufali, Romaina Iqbal, Patricio Lopez-Jaramillo, Rasha Khatib, Annika Rosengren, V Raman Kutty, Wei Li, Jiankang Liu, Xiaoyun Liu, Lu Yin, Koon Teo, Sonia Anand, Salim Yusuf
BACKGROUND: The association between intake of fruits, vegetables, and legumes with cardiovascular disease and deaths has been investigated extensively in Europe, the USA, Japan, and China, but little or no data are available from the Middle East, South America, Africa, or south Asia. METHODS: We did a prospective cohort study (Prospective Urban Rural Epidemiology [PURE] in 135 335 individuals aged 35 to 70 years without cardiovascular disease from 613 communities in 18 low-income, middle-income, and high-income countries in seven geographical regions: North America and Europe, South America, the Middle East, south Asia, China, southeast Asia, and Africa...
August 28, 2017: Lancet
https://www.readbyqxmd.com/read/28857429/tenascin-c-renders-a-proangiogenic-phenotype-in-macrophage-via-annexin-ii
#7
Zhiyang Wang, Qi Wei, Liang Han, Keqing Cao, Tianfeng Lan, Zhenjie Xu, Yingjuan Wang, Yuan Gao, Jing Xue, Fei Shan, Jun Feng, Xin Xie
Tenascin-c is an extracellular matrix glycoprotein, the expression of which relates to the progression of atherosclerosis, myocardial infarction and heart failure. Annexin II acts as a cell surface receptor of tenascin-c. This study aimed to delineate the role of tenascin-c and annexin II in macrophages presented in atherosclerotic plaque. Animal models with atherosclerotic lesions were established using ApoE-KO mice fed with high-cholesterol diet. The expression of tenascin-c and annexin II in atherosclerotic lesions was determined by qRT-PCR, Western blot and immunohistochemistry analysis...
August 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28842933/plasma-stem-cell-factor-levels-are-associated-with-risk-of-cardiovascular-disease-and-death
#8
Harry Björkbacka, Ingrid Yao Mattisson, Maria Wigren, Olle Melander, Gunilla Nordin Fredrikson, Eva Bengtsson, Isabel Gonçalves, Peter Almgren, Jens O Lagerstedt, Marju Orho-Melander, Gunnar Engström, Jan Nilsson
OBJECTIVE: Stem cell factor (SCF) is a key growth factor for several types of stem and progenitor cells. There is experimental evidence that such cells are of importance for maintaining the integrity of the cardiovascular system. We investigated the association between circulating levels of SCF and risk for development of cardiovascular events and death. METHODS: SCF was analyzed by the Proximity Extension Assay technique in plasma from 4742 subjects participating in the Malmö Diet and Cancer Study...
August 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28837523/predictors-of-early-readmission-in-hospitalized-patients-with-inflammatory-bowel-disease
#9
Kaci E Christian, Guruprasad D Jambaulikar, Matilda N Hagan, Ali M Syed, Jessica A Briscoe, Sara A Brown, Earl V Campbell, Akash B Gadani, Raymond K Cross
BACKGROUND: Readmissions are being increasingly used as an indicator of quality of care. We sought to identify risk factors for 30-day readmission in hospitalized patients with inflammatory bowel disease. METHODS: Patients with inflammatory bowel disease hospitalized between 2004 and 2013 at the University of Maryland were identified. Demographic and clinical information were extracted from the medical record for each admission. Multivariate logistic regression was performed to determine the association between these variables and readmission...
August 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28832572/mediterranean-diet-and-prognosis-of-first-diagnosed-acute-coronary-syndrome-patients-according-to-heart-failure-phenotype-hellenic-heart-failure-study
#10
M Kouvari, C Chrysohoou, P Aggelopoulos, E Tsiamis, K Tsioufis, C Pitsavos, D Tousoulis
BACKGROUND/OBJECTIVES: Nutrition in secondary prevention of Acute Coronary Syndrome (ACS) is inadequately investigated. We sought to evaluate the role of Mediterranean diet in prognosis of first-diagnosed ACS patients, according to heart failure type. SUBJECTS/METHODS: in 2006-2009, 1000 consecutive patients hospitalized at First Cardiology Clinic of Athens with ACS diagnosis were enrolled in the study. In 2016, 10-year follow-up was performed (75% participation rate)...
August 23, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28829041/loss-of-the-melanocortin-4-receptor-in-mice-causes-dilated-cardiomyopathy
#11
Michael J Litt, G Donald Okoye, Daniel Lark, Isin Cakir, Christy Moore, Mary C Barber, James Atkinson, Josh Fessel, Javid Moslehi, Roger D Cone
Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension. Thus, it has been assumed that melanocortin obesity syndrome may be protective with respect to obesity-associated cardiovascular disease. We show here that absence of the melanocortin-4 receptor (MC4R) in mice causes dilated cardiomyopathy, characterized by reduced contractility and increased left ventricular diameter...
August 22, 2017: ELife
https://www.readbyqxmd.com/read/28827564/the-profile-of-selected-single-nucleotide-polymorphisms-in-patients-with-hypertension-and-heart-failure-with-preserved-and-mid-range-ejection-fraction
#12
Agata Bielecka-Dabrowa, Agata Sakowicz, Tadeusz Pietrucha, Małgorzata Misztal, Piotr Chruściel, Jacek Rysz, Maciej Banach
The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A]...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822504/is-smog-innocuous-air-pollution-and-cardiovascular-disease
#13
EDITORIAL
Sundeep Mishra
Air pollution is a significant environmental and health hazard. Earlier studies had examined the adverse health effects associated with short- and long-term exposure to particulate matter on respiratory disease. However, later studies demonstrated that was actually cardiovascular disease that accounted for majority of mortality. Furthermore, it was not gaseous pollutants like oxides of nitrate, sulfur, carbon mono-oxide or ozone but the particulate matter or PM, of fine or coarse size (PM2.5 and PM10) which was linearly associated with mortality; PM2...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28817856/back-to-basics-the-effect-of-healthy-diet-and-exercise-on-chronic-disease-management
#14
Robert L Allison
INTRODUCTION: The increase in obesity rates in the U.S. and other less developed industrial countries have led to a worldwide epidemic of chronic disease states. Increased obesity rates are implicated in the treatment failures for illnesses such as coronary artery disease, diabetes, heart failure, hypertension and cancer. Effective prevention of obesity through diet and exercise contributes to the successful medical management of multiple chronic disease states. OBJECTIVE: Review the last 10 years of literature (2006-2016) on the effects of diet and exercise as they relate to the prevention of chronic disease...
2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28801055/therapy-with-mesenchymal-stromal-cells-or-conditioned-medium-reverse-cardiac-alterations-in-a-high-fat-diet-induced-obesity-model
#15
P S Daltro, B C Barreto, P G Silva, P Chenaud Neto, P H F Sousa Filho, D Santana Neta, G B Carvalho, D N Silva, B D Paredes, A C de Alcantara, L A R Freitas, R D Couto, R R Santos, B S F Souza, M B P Soares, S G Macambira
BACKGROUND: Obesity is associated with numerous cardiac complications, including arrhythmias, cardiac fibrosis, remodeling and heart failure. Here we evaluated the therapeutic potential of mesenchymal stromal cells (MSCs) and their conditioned medium (CM) to treat cardiac complications in a mouse model of high-fat diet (HFD)-induced obesity. METHODS: After obesity induction and HFD withdrawal, obese mice were treated with MSCs, CM or vehicle. Cardiac function was assessed using electrocardiography, echocardiography and treadmill test...
August 8, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28772030/the-renal-cardiac-connection-in-subjects-with-preserved-ejection-fraction-a-population-based-study
#16
Amit Jain, Christopher Scott, Horng H Chen
AIMS: Chronic kidney disease (CKD) is prevalent and is associated with increased cardiovascular morbidity and mortality. The interaction between diastolic dysfunction (DD) and CKD in subjects with preserved systolic function is not well defined. This study sought to determine the association between renal function and DD in subjects with preserved ejection fraction. METHODS AND RESULTS: Through the Rochester Epidemiology Project, subjects who underwent echocardiography over 2 years with EF ≥50% were identified and the clinical data were obtained...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28761677/comparison-of-the-chronic-kidney-disease-epidemiology-collaboration-the-modification-of-diet-in-renal-disease-study-and-the-cockcroft-gault-equation-in-patients-with-heart-failure
#17
Karolina Szummer, Marie Evans, Juan Jesus Carrero, Urban Alehagen, Ulf Dahlström, Lina Benson, Lars H Lund
BACKGROUND: It is unknown how the creatinine-based renal function estimations differ for dose adjustment cut-offs and risk prediction in patients with heart failure. METHOD AND RESULTS: The renal function was similar with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (median 59 mL/min/1.73 m(2), IQR 42 to 77) and Modification of Diet in Renal Disease Study (MDRD) (59 mL/min/1.73 m(2), IQR 43 to 75) and slightly lower with the Cockcroft-Gault (CG) equation (57 mL/min, IQR 39 to 82)...
2017: Open Heart
https://www.readbyqxmd.com/read/28757792/a-heart-failure-management-program-using-shared-medical-appointments
#18
Allison J Carroll, Hillary L Howrey, Susan Payvar, Kristen Deshida-Such, Mayank Kansal, Charanjit K Brar
BACKGROUND: Disease management programs for heart failure (HF) effectively reduce HF-related hospitalization rates and mortality. Shared medical appointments (SMAs) offer a cost-effective delivery method for HF disease management programs. However, few studies have evaluated this cost-effective delivery method of HF disease management among Veterans with acute HF. We hypothesized that Veterans who attended a multidisciplinary HF-SMA clinic promoting HF self-management, compared those who only received individual treatment through the HF specialty clinic, would have better 12-month hospitalization outcomes...
April 2017: Federal Practitioner: for the Health Care Professionals of the VA, DoD, and PHS
https://www.readbyqxmd.com/read/28750406/a-high-fat-diet-during-pregnancy-and-lactation-induces-cardiac-and-renal-abnormalities-in-glut4-male-mice
#19
Michael Kruse, Ariana Fiallo, Jianling Tao, Katalin Susztak, Kerstin Amann, Ellen B Katz, Maureen J Charron
BACKGROUND/AIMS: Altered nutrients during the in utero (IU) and/or lactation (L) period predispose offspring to cardio-renal diseases in adulthood. This study investigates the effect of a high fat diet (HFD) fed to female mice during IU/L on gene expression patterns associated with heart and kidney failure and hypertension in male offspring. METHODS: Female wild type (WT) mice were fed either a HFD or control chow (C) prior to mating with males with a genetic heterozygous deletion of GLUT4 (G4+/-, a model of peripheral insulin resistance and hypertension) and throughout IU/L...
July 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28746929/excessive-maternal-orange-intake-a-reversible-etiology-of-fetal-premature-ductus-arteriosus-constriction-a-case-report
#20
Shaimaa Rakha
Ductus arteriosus (DA) is a crucial element in the fetal circulation. Therefore, premature constriction of DA during the third trimester can have hazardous complications such as right ventricular dysfunction, fetal heart failure, hydrops, and even in utero demise. Normally, premature constriction is prevented by a balance between prostaglandin E2 and fetal oxygenation. Thus, drugs with antiprostaglandin effects are well-known causes for fetal DA constriction. A similar effect was discovered in eating polyphenol-rich food...
2017: Fetal Diagnosis and Therapy
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