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https://www.readbyqxmd.com/read/29044170/phosphorylation-regulates-the-subcellular-localization-of-cucumber-mosaic-virus-2b-protein
#1
Katalin Nemes, Ákos Gellért, Asztéria Almási, Pál Vági, Réka Sáray, Katalin Kádár, Katalin Salánki
The 2b protein of Cucumber mosaic virus has a role in nearly all steps of the viral cycle including cell-to-cell movement, symptom induction and suppression of antiviral RNA silencing. Previous studies demonstrated the presence of 2b protein in the nucleus and in cytoplasm as well. Phosphorylation site of 2b protein is conserved in all CMV isolates, including proposed constitute motifs for casein kinase II and cyclin-dependent kinase 2. To discern the impact of 2b protein phosphorylation, we created eight different mutants to mimic the non-phosporylated (serine to alanine) as well as the phosphorylated state (serine to aspartic acid) of the protein...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892450/2015-pandemic-influenza-readiness-assessment-among-us-public-health-emergency-preparedness-awardees
#2
Thomas J Fitzgerald, Danielle L Moulia, Samuel B Graitcer, Sara J Vagi, Stephanie A Dopson
OBJECTIVES: To assess how US Public Health Emergency Preparedness (PHEP) awardees plan to respond to an influenza pandemic with vaccination. METHODS: The Centers for Disease Control and Prevention developed the Pandemic Influenza Readiness Assessment, an online survey sent to PHEP directors, to analyze, in part, the readiness of PHEP awardees to vaccinate 80% of the populations of their jurisdictions with 2 doses of pandemic influenza vaccine, separated by 21 days, within 16 weeks of vaccine availability...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28892441/improvements-in-state-and-local-planning-for-mass-dispensing-of-medical-countermeasures-the-technical-assistance-review-program-united-states-2007-2014
#3
COMPARATIVE STUDY
Paul G Renard, Sara J Vagi, Chris M Reinold, Brenda L Silverman, Rachel N Avchen
OBJECTIVES: To evaluate and describe outcomes of state and local medical countermeasure preparedness planning, which is critical to ensure rapid distribution and dispensing of a broad spectrum of life-saving medical assets during a public health emergency. METHODS: We used 2007 to 2014 state and local data collected from the Centers for Disease Control and Prevention's Technical Assistance Review. We calculated descriptive statistics from 50 states and 72 local Cities Readiness Initiative jurisdictions that participated in the Technical Assistance Review annually...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28892440/progress-in-public-health-emergency-preparedness-united-states-2001-2016
#4
Bhavini Patel Murthy, Noelle-Angelique M Molinari, Tanya T LeBlanc, Sara J Vagi, Rachel N Avchen
OBJECTIVES: To evaluate the Public Health Emergency Preparedness (PHEP) program's progress toward meeting public health preparedness capability standards in state, local, and territorial health departments. METHODS: All 62 PHEP awardees completed the Centers for Disease Control and Prevention's self-administered PHEP Impact Assessment as part of program review measuring public health preparedness capability before September 11, 2001 (9/11), and in 2014. We collected additional self-reported capability self-assessments from 2016...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28862330/defining-the-neural-fulcrum-for-chronic-vagus-nerve-stimulation-implications-for-integrated-cardiac-control
#5
Jeffrey L Ardell, Heath Nier, Matthew Hammer, E Marie Southerland, Christopher L Ardell, Eric Beaumont, Bruce H KenKnight, J Andrew Armour
KEY POINTS: The evoked cardiac response to bipolar cervical vagus nerve stimulation (VNS) reflects a dynamic interaction between afferent mediated decreases in central parasympathetic drive and suppressive effects evoked by direct stimulation of parasympathetic efferent axons to the heart. The neural fulcrum is defined as the operating point, based on frequency-amplitude-pulse width, where a null heart rate response is reproducibly evoked during the on-phase of VNS. Cardiac control, based on the principal of the neural fulcrum, can be elicited from either vagus...
November 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28817330/readiness-to-vaccinate-critical-personnel-during-an-influenza-pandemic-united-states-2015
#6
Danielle L Moulia, Stephanie A Dopson, Sara J Vagi, Thomas J Fitzgerald, Amy Parker Fiebelkorn, Samuel B Graitcer
OBJECTIVES: To assess the readiness to vaccinate critical infrastructure personnel (CIP) involved in managing public works, emergency services, transportation, or any other system or asset that would have an immediate debilitating impact on the community if not maintained. METHODS: We analyzed self-reported planning to vaccinate CIP during an influenza pandemic with data from 2 surveys: (1) the Program Annual Progress Assessment of immunization programs and (2) the Pandemic Influenza Readiness Assessment of public health emergency preparedness programs...
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28676377/is-there-a-connection-between-postprandial-hyperglycemia-and-igt-related-sensory-nerve-dysfunction
#7
N Németh, Z Putz, I Istenes, A E Körei, O E Vági, M Kempler, R Gandhi, G Jermendy, S Tesfaye, Á G Tabák, P Kempler
BACKGROUND AND AIMS: To assess the risk factors for sensory nerve dysfunction in subjects with isolated impaired glucose tolerance (IGT). METHODS AND RESULTS: Seventy-two people with isolated IGT (WHO 1999 criteria) and 39 gender and age-matched healthy volunteers underwent detailed clinical and neurological assessment including quantitative sensory testing using the Neurometer device (current perception threshold measurement on four limbs at three different frequencies)...
July 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28242182/desipramine-increases-cardiac-parasympathetic-activity-via-%C3%AE-2-adrenergic-mechanism-in-rats
#8
Toru Kawada, Tsuyoshi Akiyama, Shuji Shimizu, Masafumi Fukumitsu, Atsunori Kamiya, Masaru Sugimachi
Desipramine (DMI) is a blocker of neuronal norepinephrine (NE) uptake transporter. Although intravenous DMI has been shown to cause centrally-mediated sympathoinhibition and peripheral NE accumulation, its parasympathetic effect remains to be elucidated. We hypothesized that intravenous DMI activates the cardiac vagal nerve via an α2-adrenergic mechanism. Using a cardiac microdialysis technique, changes in myocardial interstitial acetylcholine (ACh) levels in the left ventricular free wall in response to intravenous DMI (1mg·kg(-1)) were examined in anesthetized rats...
February 17, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27973987/determination-of-the-priority-substances-regulated-by-2000-60-ec-and-2008-105-ec-directives-in-the-surface-waters-supplying-water-treatment-plants-of-athens-greece
#9
Spyros K Golfinopoulos, Anastasia D Nikolaou, Nikolaos S Thomaidis, Anna Maria Kotrikla, Maria C Vagi, Andreas S Petsas, Demetris F Lekkas, Themistokles D Lekkas
An investigation into the occurrence of priority substances regulated by 2000/60/EC Water Framework Directive and 2008/105/EC Directive was conducted for a period of one year in the surface water sources supplying the water treatment plants (WTPs) of Athens and in the raw water of WTPs. Samples from four reservoirs and four water treatment plants of Athens were taken seasonally. The substances are divided into seven specific groups, including eight volatile organic compounds (VOCs), diethylhexylphthalate, four organochlorine pesticides (OCPs), three organophosphorus/organonitrogen pesticides (OPPs/ONPs), four triazines and phenylurea herbicides, pentachlorophenol, and four metals...
March 21, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27896830/vagal-nerve-endings-in-visceral-pleura-and-triangular-ligaments-of-the-rat-lung
#10
Feng-Bin Wang, Yi-Han Liao, Yao-Chen Wang
The inner thoracic cavity is lined by the parietal pleura, and the lung lobes are covered by the visceral pleura. The parietal and visceral plurae form the pleural cavity that has negative pressure within to enable normal respiration. The lung tissues are bilaterally innervated by vagal and spinal nerves, including sensory and motor components. This complicated innervation pattern has made it difficult to discern the vagal vs. spinal processes in the pulmonary visceral pleura. With and without vagotomy, we identified vagal nerve fibres and endings distributed extensively in the visceral pleura ('P'-type nerve endings) and triangular ligaments ('L'-type nerve endings) by injecting wheat germ agglutinin-horseradish peroxidase as a tracer into the nucleus of solitary tract or nodose ganglion of male Sprague-Dawley rats...
February 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/27686834/integrating-pharmacies-into-public-health-program-planning-for-pandemic-influenza-vaccine-response
#11
Thomas J Fitzgerald, Yoonjae Kang, Carolyn B Bridges, Todd Talbert, Sara J Vagi, Brock Lamont, Samuel B Graitcer
BACKGROUND: During an influenza pandemic, to achieve early and rapid vaccination coverage and maximize the benefit of an immunization campaign, partnerships between public health agencies and vaccine providers are essential. Immunizing pharmacists represent an important group for expanding access to pandemic vaccination. However, little is known about nationwide coordination between public health programs and pharmacies for pandemic vaccine response planning. METHODS: To assess relationships and planning activities between public health programs and pharmacies, we analyzed data from Centers for Disease Control and Prevention assessments of jurisdictions that received immunization and emergency preparedness funding from 2012 to 2015...
November 4, 2016: Vaccine
https://www.readbyqxmd.com/read/27623694/rectal-perforation-after-incision-of-the-vaginal-canal-following-incorrect-insertion-of-a-vagi-pipe-into-the-rectum-during-total-laparoscopic-hysterectomy
#12
Shuhei Okamoto, Kentaro Nakanishi, Masatada Ono, Akemi Nozawa, Shinitsu Kitamura, Toshinobu Miyamoto, Kazuo Sengoku
No abstract text is available yet for this article.
November 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27550055/why-not-to-use-the-handgrip-test-in-the-assessment-of-cardiovascular-autonomic-neuropathy-among-patients-with-diabetes-mellitus
#13
COMPARATIVE STUDY
Anna E Körei, Miklós Kempler, Ildikó Istenes, Orsolya E Vági, Zsuzsanna Putz, Viktor J Horváth, Katalin Keresztes, Csaba Lengyel, Ádám Gy Tabák, Vincenza Spallone, Péter Kempler
OBJECTIVE: Historically, a set of 5 Cardiovascular Autonomic Reflex Tests (CARTs) were considered to be the gold standard in the assessment of Cardiovascular Autonomic Neuropathy (CAN). However, measuring diastolic Blood Pressure (BP) response to sustained handgrip is omitted in recent guidelines. We aimed to assess the association between the handgrip and the other 4 tests as well as to identify determinants of the handgrip test results in diabetic patients. PATIENTS AND METHODS: 353 patients with diabetes (DM) were recruited (age: 60...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27527265/affirmation-of-the-adoration-of-the-vagi-and-role-of-tiotropium-in-asthmatic-patients
#14
EDITORIAL
Arthur F Gelb, Jay A Nadel
No abstract text is available yet for this article.
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27293241/the-use-of-community-assessment-for-public-health-emergency-response-to-evaluate-nws-warnings
#15
Cindy H Chiu, Rebecca S Noe, John Paul Martin, Amy F Wolkin, Sara J Vagi
No abstract text is available yet for this article.
January 2014: Bulletin of the American Meteorological Society
https://www.readbyqxmd.com/read/27261816/obstetric-and-neonatal-outcome-following-minor-trauma-in-pregnancy-is-hospitalization-warranted
#16
Eran Weiner, Ohad Gluck, Michal Levy, Maya Ram, Michael Divon, Jacob Bar, Michal Kovo
OBJECTIVE: To evaluate if hospitalization of pregnant women, involved in minor trauma, for 24h of surveillance, is warranted. STUDY DESIGN: The medical files of pregnant women involved in minor trauma, during 2009-2014, at 22-42 gestational weeks, were reviewed. Minor trauma was defined as an injury severity score <3, no immediate complains, normal ultrasound evaluation, reactive non-stress test, and no regular contractions. Patients were divided into those who, according to our departmental protocol, were hospitalized for 24h observation (hospitalized group), and those who refused to be hospitalized, (non-hospitalized group)...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27245809/characteristics-of-youth-with-combined-histories-of-violent-behavior-suicidal-ideation-or-behavior-and-gun-carrying
#17
Joseph E Logan, Kevin J Vagi, Deborah Gorman-Smith
BACKGROUND: Youth reporting combined histories of nonfatal violence, suicidal ideation/behavior, and gun-carrying (VSG) are at risk for perpetrating fatal interpersonal violence and self-harm. AIMS: We characterized these youth to inform prevention efforts. METHOD: We analyzed 2004 data from 3,931 seventh-, ninth-, and 11-12th-grade youth and compared VSG youth (n = 66) with non-gun carrying youth who either had no histories of violence or suicidal thoughts/behavior (n = 1,839), histories of violence (n = 884), histories of suicidal thoughts/behaviors (n = 552), or both (n = 590)...
November 2016: Crisis
https://www.readbyqxmd.com/read/27239260/evaluation-of-the-national-weather-service-extreme-cold-warning-experiment-in-north-dakota
#18
Cindy H Chiu, Sara J Vagi, Amy F Wolkin, John Paul Martin, Rebecca S Noe
Dangerously cold weather threatens life and property. During periods of extreme cold due to wind chill, the National Weather Service (NWS) issues wind chill warnings to prompt the public to take action to mitigate risks. Wind chill warnings are based on ambient temperatures and wind speeds. Since 2010, NWS has piloted a new extreme cold warning issued for cold temperatures in wind and nonwind conditions. The North Dakota Department of Health, NWS, and the Centers for Disease Control and Prevention collaborated in conducting household surveys in Burleigh County, North Dakota, to evaluate this new warning...
January 2014: Weather, Climate, and Society (Print)
https://www.readbyqxmd.com/read/27199181/the-role-of-vagal-pathway-and-nk1-and-nk2-receptors-in-cardiovascular-and-respiratory-effects-of-neurokinin-a
#19
Katarzyna Kaczyńska, Monika Jampolska, Małgorzata Szereda-Przestaszewska
Neurokinin A (NKA) is a peptide neurotransmitter that participates in the regulation of breathing and the cardiovascular system. The purpose of the current study was to determine the cardiorespiratory pattern exerted by the systemic injection of NKA, to look at the contribution of neurokinin NK1 and NK2 receptors, and to establish the engagement of the vagal pathway in mediation of these responses. The effects of intravenous injections of NKA (50 μg/kg) were studied in anaesthetized, spontaneously breathing rats in the following experimental schemes: in neurally intact rats; and vagotomized at either midcervical or supranodosal level...
September 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27069276/surveillance-of-a-chronic-liver-disease-of-unidentified-cause-in-a-rural-setting-of-ethiopia-a-case-study
#20
Cindy Chiu, Colleen Martin, Daniel Woldemichael, Girmay W/Selasie, Israel Tareke, Richard Luce, Gidey G/Libanos, Danielle Hunt, Tesfaye Bayleyegn, Adamu Addissie, Danielle Buttke, Amsalu Bitew, Sara Vagi, Matthew Murphy, Teshale Seboxa, Daddi Jima, Asfaw Debella
BACKGROUND: An outbreak of a chronic liver disease of unidentified cause, known as "Unidentified Liver Disease (ULD)" by local communities was first observed in a rural village in Tigray, northern-Ethiopia in 2001. Little was known about the geographical extent, trend, and epidemiology of the disease. METHODS: The Ethiopian Public Health Institute (EPHI) by then Ethiopian Health and Nutrition Research Institute (EHNRI), Centers for Disease Control and Prevention, World Health Organization, and Tigray Regional Health Bureaue established the ULD surveillance system in 2009 to characterize and monitor trends for this emerging disease and to identify cases for treatment and follow up...
January 2016: Ethiopian Medical Journal
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