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https://www.readbyqxmd.com/read/29331421/hyperglycaemia-induced-mir-301a-promotes-cell-proliferation-by-repressing-p21-and-smad4-in-prostate-cancer
#1
Xiaojuan Li, Jun Li, Yi Cai, Shubin Peng, Jun Wang, Zhaoming Xiao, Yu Wang, Yiran Tao, Jun Li, Qu Leng, Dinglan Wu, Shaodong Yang, Ziliang Ji, Yuefu Han, Liren Li, Xin Gao, Chunxian Zeng, Xingqiao Wen
Hyperglycaemia promotes the development of Prostate cancer (PCa). However, the roles of miRNAs in this disease process and the underlying mechanisms are largely unknown. In this study, we recruited 391 PCa patients in China and found that PCa patients with high level blood glucose (≥100 mg/dL) trended to have high Gleason score (GS≥7). miRNA-301a levels were significantly higher in prostate cancer than that in normal prostate tissues. Hyperglycaemia or high glucose treatment induced miR-301a expression in prostate tissues or PCa cell lines...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29330286/agonist-induced-cxcr4-and-cb2-heterodimerization-inhibits-g%C3%AE-13-rhoa-mediated-migration
#2
Kisha A Scarlett, ElShaddai Z White, Christopher J Coke, Jada R Carter, Latoya K Bryant, Cimona V Hinton
G-protein coupled receptor (GPCR) heterodimerization has emerged as a means by which alternative signaling entities can be created; yet, how receptor heterodimers affect receptor pharmacology remains unknown. Previous observations suggested a biochemical antagonism between GPCRs, CXCR4 and CB2 (CNR2), where agonist-bound CXCR4 and agonist-bound CB2 formed a physiologically non-functional heterodimer on the membrane of cancer cells, inhibiting their metastatic potential in vitro. However, the reduced signaling entities responsible for the observed functional outputs remain elusive...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29328471/prostaglandin-e2-receptor-ep4-is-involved-in-the-cell-growth-and-invasion-of-prostate-cancer-via-the-camp%C3%A2-pka-pi3k%C3%A2-akt-signaling-pathway
#3
Song Xu, Wenquan Zhou, Jingping Ge, Zhengyu Zhang
Prostate cancer (PCa) is one of the most prevalent diagnosed malignancies globally. Previous studies have demonstrated that prostaglandin E2 (PGE2) is closely associated with the tumorigenesis and progression of PCa. However, the underlying molecular mechanisms remain unclear and require further investigation. Matrix metalloproteinases (MMPs), receptor activator of nuclear factor‑κB ligand (RANKL) and runt‑related transcription factor 2 (RUNX2), which are involved in cell growth and bone metastasis, are frequently activated or overexpressed in various types of cancer, including PCa...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328468/microrna%C3%A2-136-inhibits-prostate-cancer-cell-proliferation-and-invasion-by-directly-targeting-mitogen%C3%A2-activated-protein-kinase-kinase-4
#4
Yudi Zhu, Siliang Shao, Huafeng Pan, Zhongliang Cheng, Xin Rui
Prostate cancer (PCa) is the second most common type of cancer and the 6th leading cause of cancer‑associated mortality worldwide. Accumulated evidence suggests that PCa initiation and progression are controlled by microRNAs (miRNAs). Therefore, investigating PCa‑associated miRNAs may provide novel biomarkers for the diagnosis and treatment of patients with PCa. In the present study it was demonstrated that miRNA‑136 (miR‑136) expression was significantly downregulated in PCa tissues and cell lines...
January 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327946/posttranscriptional-regulation-of-human-antigen-r-by-mir-133b-enhances-docetaxel-cytotoxicity-through-the-inhibition-of-atp-binding-cassette-subfamily-g-member-2-in-prostate-cancer-cells
#5
Hui Liu, Xiaolong Song, Junqing Hou, Zhenhua Zhao, Junkai Chang
Docetaxel (DTX)-based chemotherapy is a first-line therapy in patients with castration-resistant prostate cancer. However, development of DTX resistance remains a challenge in cancer treatment. miRNAs have been shown to be involved in drug resistance in tumors. Nevertheless, little is known about the function and detailed molecular mechanism of miR-133b in DTX resistance of prostate cancer cells. The current study showed that miR-133b was downregulated, while human antigen R (HuR) was upregulated in prostate cancer cells...
January 12, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29325451/expression-of-sestrin-genes-in-radiotherapy-for-prostate-cancer-and-its-association-with-fatigue-a-proof-of-concept-study
#6
Velda J Gonzalez, Farnoosh Abbas-Aghababazadeh, Brooke L Fridley, Tomar Ghansah, Leorey N Saligan
Genetic factors that influence inflammation and energy production/expenditure in cells may affect patient outcomes following treatment with external beam radiation therapy (EBRT). Sestrins, stress-inducible genes with antioxidant properties, have recently been implicated in several behaviors including fatigue. This proof-of-concept study explored whether the sestrin family of genes ( SESN1, SESN2, and SESN3) were differentially expressed from baseline to the midpoint of EBRT in a sample of 26 Puerto Rican men with nonmetastatic prostate cancer...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29323532/identification-of-cdk2-as-a-novel-target-in-treatment-of-prostate-cancer
#7
Xifeng Yin, Jun Yu, Yang Zhou, Chengyue Wang, Zhimin Jiao, Zhounan Qian, Hao Sun, Binghai Chen
AIM: This study aims the potential gene involved in the metastasis of prostate cancer (Pca). METHODS: PubMed GEO datasets (GSE6605 and GSE6606) were downloaded. We used multiple bioinformatics methods to screen differentially expressed genes in Pca. Gene network was built by STRING and visualized by Cytoscape. All of the hub genes were analyzed by cBioPortal. Inhibition of CDK2 including siRNA, inhibitor and cas9-induced CDK2 knockout was followed by an invasion assay...
January 11, 2018: Future Oncology
https://www.readbyqxmd.com/read/29321092/microrna-212-targets-mitogen-activated-protein-kinase-1-to-inhibit-proliferation-and-invasion-of-prostate-cancer-cells
#8
Bo Hu, Xunbo Jin, Jianbo Wang
Prostate cancer (PCa) is the second most commonly diagnosed malignancy and the fifth leading cause of cancer-related deaths in males worldwide. MicroRNAs (miRNAs) may serve as important regulators in PCa occurrence and development. Therefore, understanding the expression and functions of PCa-related miRNAs may be beneficial for the identification of novel therapeutic methods for patients with PCa. In this study, miRNA-212 (miR-212) was evidently downregulated in PCa tissues and several PCa cell lines. Functional assays showed that the resumption expression of miR-212 attenuated cell proliferation and invasion and increased the apoptosis of PCa...
January 10, 2018: Oncology Research
https://www.readbyqxmd.com/read/29319382/ctc-derived-ar-v7-detection-as-a-prognostic-and-predictive-biomarker-in-advanced-prostate-cancer
#9
Diogo A Bastos, Emmanuel S Antonarakis
Prostate cancer is a highly heterogeneous disease, with remarkably different prognosis across all stages. Increased circulating tumor cell (CTC) count (≥ 5) using the CellSearch assay has been identified as one of the markers that can be used to predict survival, with added value beyond currently available prognostic factors. Recently, androgen receptor splice variant 7 (AR-V7) detection has been associated with worse outcomes for patients with castration-resistant prostate cancer (CRPC) treated with novel androgen receptor-signaling (ARS) inhibitors such as abiraterone and enzalutamide but not taxane chemotherapies...
January 10, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29316842/integrative-transcriptome-analysis-identifies-genes-and-pathways-associated-with-enzalutamide-resistance-of-prostate-cancer
#10
Subo Qian, Jia Xia, Hailong Liu, Yu Zhang, Lin Zhang, Yongjiang Yu
BACKGROUND: Enzalutamide, a novel androgen receptor (AR) signaling inhibitor, has been widely used to increase survival in patients with castration-resistant prostate cancer. However, resistance to enzalutamide invariably develops. METHODS: To understand the underlying mechanisms of resistance to enzalutamide, we performed integrative analysis on multiple transcriptome datasets to identify those genes constantly up- or down-regulated in response to enzalutamide treatment...
January 9, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29316360/a-novel-prodrug-of-a-%C3%AE-glutamylcyclotransferase-inhibitor-suppresses-cancer-cell-proliferation-in%C3%A2-vitro-and-inhibits-tumor-growth-in-a-xenograft-mouse-model-of-prostate-cancer
#11
Hiromi Ii, Taku Yoshiya, Susumu Nakata, Keiko Taniguchi, Koushi Hidaka, Shugo Tsuda, Masayoshi Mochizuki, Yuji Nishiuchi, Yuko Tsuda, Kosei Ito, Susumu Kageyama, Tatsuhiro Yoshiki
γ-Glutamylcyclotransferase (GGCT) depletion inhibits cancer cell proliferation. However, whether the enzymatic activity of GGCT is critical for the regulation of cancer cell growth remains unclear. In this study, a novel diester-type cell-permeable prodrug, pro-GA, was developed based on the structure of N-glutaryl-l-alanine (GA), by structure optimization using temporary fluorophore-tagged prodrug candidates. The antiproliferative activity of pro-GA was demonstrated using GGCT-overexpressing NIH-3T3 cells and human cancer cells including MCF7, HL-60, and PC3 cells...
January 9, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29315168/novel-methods-for-reporting-of-exercise-dose-and-adherence-an-exploratory-analysis
#12
Tormod S Nilsen, Jessica M Scott, Meghan Michalski, Catherine Capaci, Samantha Thomas, James E Herndonx, John Sasso, Neil D Eves, Lee W Jones
PURPOSE: To explore whether methods adapted from oncology pharmacological trials have utility in reporting adherence (tolerability) of exercise treatment in cancer. METHODS: Using a retrospective analysis of a randomized trial, 25 prostate cancer patients received an aerobic training regimen of 72 supervised treadmill walking sessions delivered thrice-weekly between 55% to 100% of exercise capacity for 24 consecutive weeks. Treatment adherence (tolerability) was assessed using conventional (lost to follow up (LTF) and attendance) and exploratory [e...
January 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29311591/segmented-cell-analyses-to-measure-redox-states-of-autofluorescent-nad-p-h-fad-trp-in-cancer-cells-by-flim
#13
Horst Wallrabe, Zdenek Svindrych, Shagufta R Alam, Karsten H Siller, Tianxiong Wang, David Kashatus, Song Hu, Ammasi Periasamy
Multiphoton FLIM microscopy offers many opportunities to investigate processes in live cells, tissue and animal model systems. For redox measurements, FLIM data is mostly published by cell mean values and intensity-based redox ratios. Our method is based entirely on FLIM parameters generated by 3-detector time domain microscopy capturing autofluorescent signals of NAD(P)H, FAD and novel FLIM-FRET application of Tryptophan and NAD(P)H-a2%/FAD-a1% redox ratio. Furthermore, image data is analyzed in segmented cells thresholded by 2 × 2 pixel Regions of Interest (ROIs) to separate mitochondrial oxidative phosphorylation from cytosolic glycolysis in a prostate cancer cell line...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29301749/in-situ-detection-and-quantification-of-ar-v7-ar-fl-psa-and-kras-point-mutations-in-circulating-tumor-cells
#14
Amin El-Heliebi, Claudia Hille, Navya Laxman, Jessica Svedlund, Christoph Haudum, Erkan Ercan, Thomas Kroneis, Shukun Chen, Maria Smolle, Christopher Rossmann, Tomasz Krzywkowski, Annika Ahlford, Evangelia Darai, Gunhild von Amsberg, Winfried Alsdorf, Frank König, Matthias Löhr, Inge de Kruijff, Sabine Riethdorf, Tobias M Gorges, Klaus Pantel, Thomas Bauernhofer, Mats Nilsson, Peter Sedlmayr
BACKGROUND: Liquid biopsies can be used in castration-resistant prostate cancer (CRPC) to detect androgen receptor splice variant 7 (AR-V7), a splicing product of the androgen receptor. Patients with AR-V7-positive circulating tumor cells (CTCs) have greater benefit of taxane chemotherapy compared with novel hormonal therapies, indicating a treatment-selection biomarker. Likewise, in those with pancreatic cancer (PaCa), KRAS mutations act as prognostic biomarkers. Thus, there is an urgent need for technology investigating the expression and mutation status of CTCs...
January 4, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29290963/prognostic-factors-in-men-with-metastatic-castration-resistant-prostate-cancer-treated-with-cabazitaxel
#15
Bodine P S Belderbos, Ronald de Wit, Esther Oomen-de Hoop, Annemieke Nieuweboer, Paul Hamberg, Robbert J van Alphen, André Bergman, Nelly van der Meer, Sander Bins, Ron H J Mathijssen, Robert J van Soest
Background: Treatment selection for men with metastatic castration-resistant prostate cancer (mCRPC) has become increasingly challenging with the introduction of novel therapies at earlier disease stages. The purpose of this study was to identify prognostic factors for overall survival (OS) and PSA response in patients with mCRPC treated with cabazitaxel. Results: 224 mCRPC patients were included in the current analysis. In multivariable analysis, WHO performance status, baseline hemoglobin, alkaline phosphatase and albumin were all significantly associated with OS...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288939/synthesis-and-anticancer-activity-of-novel-water-soluble-benzimidazole-carbamates
#16
Jae Eun Cheong, Michela Zaffagni, Ivy Chung, Yingjie Xu, Yiqiang Wang, Finith E Jernigan, Bruce R Zetter, Lijun Sun
Metastases account for more than 90% of all cancer deaths and respond poorly to most therapies. There remains an urgent need for new therapeutic modalities for the treatment of advanced metastatic cancers. The benzimidazole methylcarbamate drugs, commonly used as anti-helmitics, have been suggested to have anticancer activity, but progress has been stalled by their poor water solubility and poor suitability for systemic delivery to disseminated cancers. We synthesized and characterized the anticancer activity of novel benzimidazoles containing an oxetane or an amine group to enhance solubility...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29288594/bacillus-amyloliquefaciens-induces-production-of-a-novel-blennolide-k-in-co-culture-of-setophoma-terrestris
#17
Divya Arora, Gousia Chashoo, Venugopal Singamaneni, Nisha Sharma, Prasoon Gupta, Sundeep Jaglan
AIMS: The discovery of known bioactive chemical leads from microbial mono-cultures hinders the efficiency of drug discovery programs. Therefore, in recent years, the use of fungal bacterial co-culture experiments has gained considerable attention due to their ability to generate new bioactive leads. In this work, fungal strain Setophoma terrestris was co-cultured with Bacillus amyloliquifaciens to discover novel bioactive compounds. MATERIALS AND METHODS: The bioactive methanolic co-culture extract was chosen for the isolation of compounds by chromatographic methods...
December 30, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29286150/mitochondrial-pyruvate-carrier-modulates-the-epithelial-mesenchymal-transition-in-cholangiocarcinoma
#18
Tomofumi Ohashi, Hidetoshi Eguchi, Koichi Kawamoto, Masamitsu Konno, Ayumu Asai, Hugh Colvin, Yuji Ueda, Hirofumi Takaoka, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Shogo Kobayashi, Jun Koseki, Taroh Satoh, Kazuhiko Ogawa, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Intrahepatic cholangiocarcinoma (ICC) is known to have a high malignant potential. Because of its high recurrence rate, ICC has a poor prognosis even after complete tumor resection. Compared with normal differentiated cells, cancer cells have an altered metabolism for supporting their survival in severe conditions. Cancer cells acquire additional malignant potential as a result of this metabolic alteration. Thus, the molecules known to be involved in cancer metabolism, could be novel therapeutic targets. The mitochondrial pyruvate carrier (MPC) is a recently discovered pyruvate transporter, which is located in the mitochondrial inner membrane...
December 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29286137/microrna-124a-inhibits-cell-proliferation-and-migration-in-liver-cancer-by-regulating-interleukin-11
#19
Liedao Yu, Shuo Wang, Xiangjin Lin, Yang Lu, Pengcheng Gu
Liver cancer is the sixth most common malignant tumour and ranks in the top three cancers with regard to mortality due to metastasis and postsurgical recurrence. It is significant to understand the mechanisms underlying liver cancer for diagnosis and treatment. Cumulative evidence suggests that the abnormal regulation of microRNAs (miRNAs/miRs) may contribute to the development and metastasis of cancer. miR‑124a acts as a tumour suppressor in osteosarcoma, endometrial carcinoma, prostate cancer, and glioblastoma...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29283440/cabozantinib-a-multi-targeted-oral-tyrosine-kinase-inhibitor
#20
Jordan N Markowitz, Karen M Fancher
Cabozantinib is an oral, small-molecule, multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It has been approved by the United States Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid cancer, and is being investigated for a wide array of other malignancies. Rationale for use, clinical trial data, and current recommendations for cabozantinib in renal cell cancer, thyroid cancer, prostate cancer, hepatocellular cancer, and lung cancer are detailed in this article...
December 28, 2017: Pharmacotherapy
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