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Edward Maclean

Kazuo Imaizumi, Edward S Ruthazer, Jason N MacLean, Charles C Lee
No abstract text is available yet for this article.
2018: Frontiers in Neural Circuits
Philip I Terrill, Carolyn Dakin, Bradley A Edwards, Stephen J Wilson, Joanna E MacLean
STUDY OBJECTIVES: Pulse-oximetry (SpO2 ) allows the identification of important clinical physiology. However, summary statistics such as mean values and desaturation incidence do not capture the complexity of the information contained within continuous recordings. The aim of this study was to develop an objective method to quantify important SpO2 characteristics; and assess its utility in healthy infant and preterm neonate cohorts. METHODS: An algorithm was developed to calculate the desaturation incidence, depth, and duration...
March 24, 2018: Pediatric Pulmonology
Qiue Yang, Mei Li, Owen B Spiller, Diego O Andrey, Philip Hinchliffe, Hui Li, Craig MacLean, Pannika Niumsup, Lydia Powell, Manon Pritchard, Andrei Papkou, Yingbo Shen, Edward Portal, Kirsty Sands, James Spencer, Uttapoln Tansawai, David Thomas, Shaolin Wang, Yang Wang, Jianzhong Shen, Timothy Walsh
MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability and significant degradation in cell membrane and cytoplasmic structures, compared to expression of catalytically inactive MCR-1 (E246A) or MCR-1 soluble component. Lipopolysaccharide (LPS) extracted from mcr-1 strains induces lower production of IL-6 and TNF, when compared to control LPS...
December 12, 2017: Nature Communications
Victoria A Catenacci, Zhaoxing Pan, Danielle Ostendorf, Sarah Brannon, Wendolyn S Gozansky, Mark P Mattson, Bronwen Martin, Paul S MacLean, Edward L Melanson, William Troy Donahoo
OBJECTIVE: To evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR). METHODS: Adults with obesity (BMI ≥30 kg/m(2) , age 18-55) were randomized to either zero-calorie ADF (n = 14) or CR (-400 kcal/day, n = 12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up...
September 2016: Obesity
Ghanasyam Rallapalli, Diane Go Saunders, Kentaro Yoshida, Anne Edwards, Carlos A Lugo, Steve Collin, Bernardo Clavijo, Manuel Corpas, David Swarbreck, Matthew Clark, J Allan Downie, Sophien Kamoun, Dan MacLean
In 2013, in response to an epidemic of ash dieback disease in England the previous year, we launched a Facebook-based game called Fraxinus to enable non-scientists to contribute to genomics studies of the pathogen that causes the disease and the ash trees that are devastated by it. Over a period of 51 weeks players were able to match computational alignments of genetic sequences in 78% of cases, and to improve them in 15% of cases. We also found that most players were only transiently interested in the game, and that the majority of the work done was performed by a small group of dedicated players...
July 29, 2015: ELife
Jacqueline Willmore, Edward Ellis, Vera Etches, Lise Labrecque, Carla Osiowy, Anton Andonov, Cameron McDermaid, Anna Majury, Camille Achonu, Maurica Maher, Brenda MacLean, Isra Levy
OBJECTIVE: To determine whether transmission of blood-borne pathogens (BBPs) (hepatitis B virus [HBV], hepatitis C virus [HCV] and HIV) occurred as a result of endoscopy reprocessing failures identified during an inspection of a nonhospital endoscopy clinic in 2011. METHODS: The present analysis was a retrospective cohort study. Registered notification letters were mailed to 6992 patients who underwent endoscopy from 2002 to 2011 at one Canadian nonhospital endoscopy clinic, informing them of the infection control lapse and offering BBP testing...
March 2015: Canadian Journal of Infectious Diseases & Medical Microbiology
Simon B M MacLean, Christopher Timmis, Scott Evans, Dominik Lawniczak, Amit Nijran, Edward Bache
PURPOSE: To review the records of 50 children who underwent open joint washout for septic arthritis with (n=25) or without (n=25) preoperative antibiotics. METHODS: Records of 50 children who underwent open joint washout for presumed septic arthritis with (n=25) or without (n=25) preoperative antibiotics were reviewed. 17 boys and 8 girls aged 3 weeks to 16 years (median, 1.5 years) who were prescribed preoperative antibiotics before joint washout were compared with 12 boys and 13 girls aged one month to 14 years (median, 2 years) who were not...
April 2015: Journal of Orthopaedic Surgery
Harold E Bays, Eliot A Brinton, Joseph Triscari, Erluo Chen, Darbie Maccubbin, Alexandra A MacLean, Kendra L Gibson, Rae Ann Ruck, Amy O Johnson-Levonas, Edward A O'Neill, Yale B Mitchel
BACKGROUND: The degree of glycemic control in patients with type 2 diabetes mellitus (T2DM) may alter lipid levels and may alter the efficacy of lipid-modifying agents. OBJECTIVE: Evaluate the lipid-modifying efficacy of extended-release niacin/laropiprant (ERN/LRPT) in subgroups of patients with T2DM with better or poorer glycemic control. METHODS: Post hoc analysis of clinical trial data from patients with T2DM who were randomized 4:3 to double-blind ERN/LRPT or placebo (n=796), examining the lipid-modifying effects of ERN/LRPT in patients with glycosylated hemoglobin or fasting plasma glucose levels above and below median baseline levels...
2015: Vascular Health and Risk Management
Robert D Annett, Sarah Hile, Edward Bedrick, Alicia S Kunin-Batson, Kevin R Krull, Leanne Embry, Willliam E MacLean, Robert B Noll
OBJECTIVES: To provide one of the first prospective reports examining neuropsychological outcomes for children treated with 1800 cGy whole brain radiotherapy (WBRT) and prophylactic chemotherapy versus prophylactic chemotherapy alone for acute lymphoblastic leukemia (ALL). Acute and long-term neuropsychological toxicities associated with WBRT are compared. METHODS: This multisite study included 188 children, ages 4-21 years at enrollment, who were assessed with standardized neuropsychological tests at 9, 21, and 48 months after diagnosis with intermediate risk ALL...
February 2015: Psycho-oncology
Louise Maclean, David Reiss, Seán Whyte, Simon Christopherson, Edward Petch, Catherine Penny
Stalking is a well-recognized social phenomenon, one that particularly affects health care professionals, especially psychiatrists and other mental health workers; however, the nature and effects of stalking of psychiatrists have not been examined in detail. This study is a qualitative thematic analysis of the free-text responses of 2,585 psychiatrists in the United Kingdom (approximately 25% of all U.K. psychiatrists), almost 11 percent of whom described being stalked according to a strict research definition, and 21 percent of whom perceived themselves as having been stalked...
2013: Journal of the American Academy of Psychiatry and the Law
Gazi S Hossain, Edward G Lynn, Kenneth N Maclean, Ji Zhou, Jeffrey G Dickhout, Sárka Lhoták, Bernardo Trigatti, John Capone, Jaerang Rho, Damu Tang, Christopher A McCulloch, Imtisal Al-Bondokji, Mary J Malloy, Clive R Pullinger, John P Kane, Yonghong Li, Dov Shiffman, Richard C Austin
BACKGROUND: Apoptosis caused by endoplasmic reticulum (ER) stress contributes to atherothrombosis, the underlying cause of cardiovascular disease (CVD). T-cell death-associated gene 51 (TDAG51), a member of the pleckstrin homology-like domain gene family, is induced by ER stress, causes apoptosis when overexpressed, and is present in lesion-resident macrophages and endothelial cells. METHODS AND RESULTS: To study the role of TDAG51 in atherosclerosis, male mice deficient in TDAG51 and apolipoprotein E (TDAG51(-/-)/ApoE(-/-)) were generated and showed reduced atherosclerotic lesion growth (56 ± 5% reduction at 40 weeks, relative to ApoE(-/-) controls, P<0...
June 2013: Journal of the American Heart Association
Dan Maclean, Kentaro Yoshida, Anne Edwards, Lisa Crossman, Bernardo Clavijo, Matt Clark, David Swarbreck, Matthew Bashton, Patrick Chapman, Mark Gijzen, Mario Caccamo, Allan Downie, Sophien Kamoun, Diane Go Saunders
Ash dieback is a devastating fungal disease of ash trees that has swept across Europe and recently reached the UK. This emergent pathogen has received little study in the past and its effect threatens to overwhelm the ash population. In response to this we have produced some initial genomics datasets and taken the unusual step of releasing them to the scientific community for analysis without first performing our own. In this manner we hope to 'crowdsource' analyses and bring the expertise of the community to bear on this problem as quickly as possible...
2013: GigaScience
Sana Basseri, Sárka Lhoták, Morgan D Fullerton, Rengasamy Palanivel, Hua Jiang, Edward G Lynn, Rebecca J Ford, Kenneth N Maclean, Gregory R Steinberg, Richard C Austin
Regulation of energy metabolism is critical for the prevention of obesity, diabetes, and hepatic steatosis. Here, we report an important role for the pleckstrin homology-related domain family member, T-cell death-associated gene 51 (TDAG51), in the regulation of energy metabolism. TDAG51 expression was examined during adipocyte differentiation. Adipogenic potential of preadipocytes with knockdown or absence of TDAG51 was assessed. Weight gain, insulin sensitivity, metabolic rate, and liver lipid content were also compared between TDAG51-deficient (TDAG51(-/-)) and wild-type mice...
January 2013: Diabetes
Margaret C Neville, Steven M Anderson, James L McManaman, Thomas M Badger, Maya Bunik, Nikhat Contractor, Tessa Crume, Dana Dabelea, Sharon M Donovan, Nicole Forman, Daniel N Frank, Jacob E Friedman, J Bruce German, Armond Goldman, Darryl Hadsell, Michael Hambidge, Katie Hinde, Nelson D Horseman, Russell C Hovey, Edward Janoff, Nancy F Krebs, Carlito B Lebrilla, Danielle G Lemay, Paul S MacLean, Paula Meier, Ardythe L Morrow, Josef Neu, Laurie A Nommsen-Rivers, Daniel J Raiten, Monique Rijnkels, Victoria Seewaldt, Barry D Shur, Joshua VanHouten, Peter Williamson
This paper resulted from a conference entitled "Lactation and Milk: Defining and refining the critical questions" held at the University of Colorado School of Medicine from January 18-20, 2012. The mission of the conference was to identify unresolved questions and set future goals for research into human milk composition, mammary development and lactation. We first outline the unanswered questions regarding the composition of human milk (Section I) and the mechanisms by which milk components affect neonatal development, growth and health and recommend models for future research...
June 2012: Journal of Mammary Gland Biology and Neoplasia
Elizabeth Mortimer, James M Maclean, Sandiswa Mbewana, Amelia Buys, Anna-Lise Williamson, Inga I Hitzeroth, Edward P Rybicki
BACKGROUND: During a global influenza pandemic, the vaccine requirements of developing countries can surpass their supply capabilities, if these exist at all, compelling them to rely on developed countries for stocks that may not be available in time. There is thus a need for developing countries in general to produce their own pandemic and possibly seasonal influenza vaccines. Here we describe the development of a plant-based platform for producing influenza vaccines locally, in South Africa...
2012: BMC Biotechnology
Brett MacLean, Rosanna F Hess, Edward Bonvillain, Joseph Kamate, Daoda Dao, Amy Cosimano, Shannon Hoy
OBJECTIVE: To establish the rate of seroprevalence of the hepatitis B surface antigen in pregnant women in south-eastern Mali, and to decrease mother-to-child transmission. METHODS: In a descriptive cross-sectional comparison study, 3 659 pregnant women attending a non-governmental hospital in Koutiala, Mali, during 2008 and 2009 were screened for the hepatitis B surface antigen during antenatal clinic attendance or when admitted for delivery. A chart review compared the hepatitis B virus (HBV)-positive women to HBV-negative women used as controls to identify potential risk factors for HBsAg positivity...
January 2012: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Audrey Bergouignan, Wendolyn S Gozansky, Daniel W Barry, Wayne Leitner, Paul S MacLean, James O Hill, Boris Draznin, Edward L Melanson
In lean humans, increasing dietary fat intake causes an increase in whole-body fat oxidation and changes in genes that regulate fat oxidation in skeletal muscle, but whether this occurs in obese humans is not known. We compared changes in whole-body fat oxidation and markers of muscle oxidative capacity differ in lean (LN) and obese (OB) adults exposed to a 2-day high-fat (HF) diet. Ten LN (BMI = 22.5±2.5 kg/m², age = 30±8 yrs) and nine OB (BMI = 35.9±4.93 kg/m², 38±5 yrs, Mean±SD) were studied in a room calorimeter for 24hr while consuming isocaloric low-fat (LF, 20% of energy) and HF (50% of energy) diets...
2012: PloS One
Paul Ratcliffe, Lynn Abernethy, Nasrin Ansari, Ken Cameron, Tom Clarkson, Maureen Dempster, David Dunn, Anna-Marie Easson, Darren Edwards, Katy Everett, Helen Feilden, Koc-Kan Ho, Steve Kultgen, Peter Littlewood, John Maclean, Duncan McArthur, Deborah McGregor, Hazel McLuskey, Irina Neagu, Olaf Nimz, Lesley-Anne Nisbet, Michael Ohlmeyer, Ronnie Palin, Quynhchi Pham, Yajing Rong, Andrew Roughton, Melanie Sammons, Robert Swanson, Heather Tracey, Glenn Walker
Systematic optimisation of a poorly soluble lead series of isoxazole-3-carboxamides was conducted. Substitution of the 4-position with specific polar functionality afforded the requisite balance of potency, solubility and physicochemical properties. Compound 21a was found to be efficacious in the rat Capsaicin Hargreaves assay following oral administration.
August 1, 2011: Bioorganic & Medicinal Chemistry Letters
Amy J Steig, Matthew R Jackman, Erin D Giles, Janine A Higgins, Ginger C Johnson, Chad Mahan, Edward L Melanson, Holly R Wyatt, Robert H Eckel, James O Hill, Paul S MacLean
The impact of regular exercise on energy balance, fuel utilization, and nutrient availability, during weight regain was studied in obese rats, which had lost 17% of their weight by a calorie-restricted, low-fat diet. Weight reduced rats were maintained for 6 wk with and without regular treadmill exercise (1 h/day, 6 days/wk, 15 m/min). In vivo tracers and indirect calorimetry were then used in combination to examine nutrient metabolism during weight maintenance (in energy balance) and during the first day of relapse when allowed to eat ad libitum (relapse)...
September 2011: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Paul Ratcliffe, John Maclean, Lynn Abernethy, Tom Clarkson, Maureen Dempster, Anna-Marie Easson, Darren Edwards, Katy Everett, Helen Feilden, Peter Littlewood, Duncan McArthur, Deborah McGregor, Hazel McLuskey, Olaf Nimz, Lesley-Anne Nisbet, Ronnie Palin, Heather Tracey, Glenn Walker
Optimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration.
April 15, 2011: Bioorganic & Medicinal Chemistry Letters
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