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JOURNAL ARTICLE
Magnus Lundin, Einar Heiberg, David Nordlund, Tom Gyllenhammar, Katarina Steding-Ehrenborg, Henrik Engblom, Marcus Carlsson, Dan Atar, Jesper van der Pals, David Erlinge, Rasmus Borgquist, Ardavan Khoshnood, Ulf Ekelund, Jannike Nickander, Raquel Themudo, Sabrina Nordin, Rebecca Kozor, Anish N Bhuva, James C Moon, Eva Maret, Kenneth Caidahl, Andreas Sigfridsson, Peder Sörensson, Erik B Schelbert, Håkan Arheden, Martin Ugander
Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wall thickness (GT, GTI if indexed to body surface area) was accurately calculated from LV mass and end-diastolic volume...
December 20, 2023: Scientific Reports
#2
JOURNAL ARTICLE
Laura Pasea, Ashkan Dashtban, Mehrdad Mizani, Anish Bhuva, Tamsin Morris, Jil Billy Mamza, Amitava Banerjee
BACKGROUND: Heart failure (HF), type 2 diabetes (T2D) and chronic kidney disease (CKD) commonly coexist. We studied characteristics, prognosis and healthcare utilisation of individuals with two of these conditions. METHODS: We performed a retrospective, population-based linked electronic health records study from 1998 to 2020 in England to identify individuals diagnosed with two of: HF, T2D or CKD. We described cohort characteristics at time of second diagnosis and estimated risk of developing the third condition and mortality using Kaplan-Meier and Cox regression models...
September 2023: Open Heart
#3
JOURNAL ARTICLE
Sarah M Hooper, Sen Wu, Rhodri H Davies, Anish Bhuva, Erik B Schelbert, James C Moon, Peter Kellman, Hui Xue, Curtis Langlotz, Christopher Ré
PURPOSE: Neural networks have potential to automate medical image segmentation but require expensive labeling efforts. While methods have been proposed to reduce the labeling burden, most have not been thoroughly evaluated on large, clinical datasets or clinical tasks. We propose a method to train segmentation networks with limited labeled data and focus on thorough network evaluation. APPROACH: We propose a semi-supervised method that leverages data augmentation, consistency regularization, and pseudolabeling and train four cardiac magnetic resonance (MR) segmentation networks...
March 2023: Journal of Medical Imaging
#4
William Thomas Christopher Procter, James Elliott, Abdul H Butt, Christopher Monkhouse, Anish N Bhuva, Philip Moore
Effective rate-adaptive pacing may be difficult in the presence of atrial fibrillation (AF), and is important during high-intensity exercise. This case presents a 74-year-old elite cyclist with AF and a biventricular pacemaker after atrioventricular (AV) node ablation. He reported sudden breathlessness due to heart rate drops, caused by breaching the artefact threshold on the minute-ventilation sensor. He was exchanged to a generator with an impedance-derived contractility sensor (closed-loop stimulation), resulting in resolution of symptoms, and no further rate drops...
February 15, 2023: Pacing and Clinical Electrophysiology: PACE
#5
JOURNAL ARTICLE
Xilin Wu, Russell Senanayake, Emily Goodchild, Waiel A Bashari, Jackie Salsbury, Claudia P Cabrera, Giulia Argentesi, Samuel M O'Toole, Matthew Matson, Brendan Koo, Laila Parvanta, Nick Hilliard, Vasilis Kosmoliaptsis, Alison Marker, Daniel M Berney, Wilson Tan, Roger Foo, Charles A Mein, Eva Wozniak, Emmanuel Savage, Anju Sahdev, Nicholas Bird, Kate Laycock, Istvan Boros, Stefan Hader, Victoria Warnes, Daniel Gillett, Anne Dawnay, Elizabeth Adeyeye, Alessandro Prete, Angela E Taylor, Wiebke Arlt, Anish N Bhuva, Franklin Aigbirhio, Charlotte Manisty, Alasdair McIntosh, Alexander McConnachie, J Kennedy Cruickshank, Heok Cheow, Mark Gurnell, William M Drake, Morris J Brown
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery. However, the invasive nature of the standard pre-surgical investigation contributes to fewer than 1% of patients with PA being offered the chance of a cure. The primary objective of our prospective study of 143 patients with PA ( NCT02945904 ) was to compare the accuracy of a non-invasive test, [11 C]metomidate positron emission tomography computed tomography (MTO) scanning, with adrenal vein sampling (AVS) in predicting the biochemical remission of PA and the resolution of hypertension after surgery...
January 2023: Nature Medicine
#6
JOURNAL ARTICLE
Anish Bhuva, Geoff Charles-Edwards, Jonathan Ashmore, Alexandra Lipton, Matthew Benbow, David Grainger, Trudie Lobban, Deepa Gopalan, Alistair Slade, Giles Roditi, Charlotte Manisty
Magnetic Resonance Imaging (MRI) is increasingly a fundamental component of the diagnostic pathway across a range of conditions. Historically, the presence of a cardiac implantable electronic device (CIED) has been a contraindication for MRI, however, development of MR Conditional devices that can be scanned under strict protocols has facilitated the provision of MRI for patients. Additionally, there is growing safety data to support MR scanning in patients with CIEDs that do not have MR safety labelling or with MR Conditional CIEDs where certain conditions are not met, where the clinical justification is robust...
September 14, 2022: Heart
#7
JOURNAL ARTICLE
Catherine J Reynolds, Corinna Pade, Joseph M Gibbons, Ashley D Otter, Kai-Min Lin, Diana Muñoz Sandoval, Franziska P Pieper, David K Butler, Siyi Liu, George Joy, Nasim Forooghi, Thomas A Treibel, Charlotte Manisty, James C Moon, Amanda Semper, Tim Brooks, Áine McKnight, Daniel M Altmann, Rosemary J Boyton, Hakam Abbass, Aderonke Abiodun, Mashael Alfarih, Zoe Alldis, Daniel M Altmann, Oliver E Amin, Mervyn Andiapen, Jessica Artico, João B Augusto, Georgina L Baca, Sasha N L Bailey, Anish N Bhuva, Alex Boulter, Ruth Bowles, Rosemary J Boyton, Olivia V Bracken, Ben O'Brien, Tim Brooks, Natalie Bullock, David K Butler, Gabriella Captur, Olivia Carr, Nicola Champion, Carmen Chan, Aneesh Chandran, Tom Coleman, Jorge Couto de Sousa, Xose Couto-Parada, Eleanor Cross, Teresa Cutino-Moguel, Silvia D'Arcangelo, Rhodri H Davies, Brooke Douglas, Cecilia Di Genova, Keenan Dieobi-Anene, Mariana O Diniz, Anaya Ellis, Karen Feehan, Malcolm Finlay, Marianna Fontana, Nasim Forooghi, Sasha Francis, Joseph M Gibbons, David Gillespie, Derek Gilroy, Matt Hamblin, Gabrielle Harker, Georgia Hemingway, Jacqueline Hewson, Wendy Heywood, Lauren M Hickling, Bethany Hicks, Aroon D Hingorani, Lee Howes, Ivie Itua, Victor Jardim, Wing-Yiu Jason Lee, Melaniepetra Jensen, Jessica Jones, Meleri Jones, George Joy, Vikas Kapil, Caoimhe Kelly, Hibba Kurdi, Jonathan Lambourne, Kai-Min Lin, Siyi Liu, Aaron Lloyd, Sarah Louth, Mala K Maini, Vineela Mandadapu, Charlotte Manisty, Áine McKnight, Katia Menacho, Celina Mfuko, Kevin Mills, Sebastian Millward, Oliver Mitchelmore, Christopher Moon, James Moon, Diana Muñoz Sandoval, Sam M Murray, Mahdad Noursadeghi, Ashley Otter, Corinna Pade, Susana Palma, Ruth Parker, Kush Patel, Mihaela Pawarova, Steffen E Petersen, Brian Piniera, Franziska P Pieper, Lisa Rannigan, Alicja Rapala, Catherine J Reynolds, Amy Richards, Matthew Robathan, Joshua Rosenheim, Cathy Rowe, Matthew Royds, Jane Sackville West, Genine Sambile, Nathalie M Schmidt, Hannah Selman, Amanda Semper, Andreas Seraphim, Mihaela Simion, Angelique Smit, Michelle Sugimoto, Leo Swadling, Stephen Taylor, Nigel Temperton, Stephen Thomas, George D Thornton, Thomas A Treibel, Art Tucker, Ann Varghese, Jessry Veerapen, Mohit Vijayakumar, Tim Warner, Sophie Welch, Hannah White, Theresa Wodehouse, Lucinda Wynne, Dan Zahedi, Benjamin Chain, James C Moon
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories...
July 15, 2022: Science
#8
JOURNAL ARTICLE
Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development.
Matthew Webber, Debbie Falconer, Mashael AlFarih, George Joy, Fiona Chan, Clare Davie, Lee Hamill Howes, Andrew Wong, Alicja Rapala, Anish Bhuva, Rhodri H Davies, Christopher Morton, Jazmin Aguado-Sierra, Mariano Vazquez, Xuyuan Tao, Gunther Krausz, Slobodan Tanackovic, Christoph Guger, Hui Xue, Peter Kellman, Iain Pierce, Jonathan Schott, Rebecca Hardy, Nishi Chaturvedi, Yoram Rudy, James C Moon, Pier D Lambiase, Michele Orini, Alun D Hughes, Gabriella Captur
BACKGROUND: The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world's longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46-the cardiac sub-study of the NSHD. METHODS: We aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR)...
April 1, 2022: BMC Cardiovascular Disorders
#9
JOURNAL ARTICLE
Hui Xue, Jessica Artico, Rhodri H Davies, Robert Adam, Abhishek Shetye, João B Augusto, Anish Bhuva, Fredrika Fröjdh, Timothy C Wong, Miho Fukui, João L Cavalcante, Thomas A Treibel, Charlotte Manisty, Marianna Fontana, Martin Ugander, James C Moon, Erik B Schelbert, Peter Kellman
Background Global longitudinal shortening (GL-Shortening) and the mitral annular plane systolic excursion (MAPSE) are known markers in heart failure patients, but measurement may be subjective and less frequently reported because of the lack of automated analysis. Therefore, a validated, automated artificial intelligence (AI) solution can be of strong clinical interest. Methods and Results The model was implemented on cardiac magnetic resonance scanners with automated in-line processing. Reproducibility was evaluated in a scan-rescan data set (n=160 patients)...
February 15, 2022: Journal of the American Heart Association
#10
Lamia Al Saikhan, Muath Alobaida, Anish Bhuva, Nish Chaturvedi, John Heasman, Alun D Hughes, Siana Jones, Sophie Eastwood, Charlotte Manisty, Katherine March, Arjun K Ghosh, Jamil Mayet, Ayodipupo Oguntade, Therese Tillin, Suzanne Williams, Andrew Wright, Chloe Park
[This corrects the article DOI: 10.3389/fcvm.2020.591946.].
2021: Frontiers in Cardiovascular Medicine
#11
JOURNAL ARTICLE
Anish N Bhuva, Russell Moralee, Tamara Brunker, Karen Lascelles, Lizette Cash, Kush P Patel, Martin Lowe, Neha Sekhri, Francisco Alpendurada, Dudley J Pennell, Richard Schilling, Pier D Lambiase, Anthony Chow, James C Moon, Harold Litt, A John Baksi, Charlotte H Manisty
AIMS: Many cardiac pacemakers and defibrillators are not approved by regulators for magnetic resonance imaging (MRI). Even following generator exchange to an approved magnetic resonance (MR)-conditional model, many systems remain classified 'non-MR conditional' due to the leads. This classification makes patient access to MRI challenging, but there is no evidence of increased clinical risk. We compared the effect of MRI on non-MR conditional and MR-conditional pacemaker and defibrillator leads...
July 7, 2022: European Heart Journal
#12
JOURNAL ARTICLE
Camilla Torlasco, Andrew D'Silva, Anish N Bhuva, Andrea Faini, Joao B Augusto, Kristopher D Knott, Giulia Benedetti, Siana Jones, Jet Van Zalen, Paul Scully, Ilaria Lobascio, Gianfranco Parati, Guy Lloyd, Alun D Hughes, Charlotte H Manisty, Sanjay Sharma, James C Moon
AIMS: Remodelling of the cardiovascular system (including heart and vasculature) is a dynamic process influenced by multiple physiological and pathological factors. We sought to understand whether remodelling in response to a stimulus, exercise training, altered with healthy ageing. METHODS: A total of 237 untrained healthy male and female subjects volunteering for their first time marathon were recruited. At baseline and after 6 months of unsupervised training, race completers underwent tests including 1...
July 10, 2021: European Journal of Preventive Cardiology
#13
JOURNAL ARTICLE
Gabriella Captur, Charlotte H Manisty, Betty Raman, Alberto Marchi, Timothy C Wong, Rina Ariga, Anish Bhuva, Elizabeth Ormondroyd, Ilaria Lobascio, Claudia Camaioni, Savvas Loizos, Jenade Bonsu-Ofori, Aslan Turer, Vlad G Zaha, João B Augutsto, Rhodri H Davies, Andrew J Taylor, Arthur Nasis, Mouaz H Al-Mallah, Sinitsyn Valentin, Diego Perez de Arenaza, Vimal Patel, Mark Westwood, Steffen E Petersen, Chunming Li, Lijun Tang, Shiro Nakamori, Reza Nezafat, Raymond Y Kwong, Carolyn Y Ho, Alan G Fraser, Hugh Watkins, Perry M Elliott, Stefan Neubauer, Guy Lloyd, Iacopo Olivotto, Petros Nihoyannopoulos, James C Moon
OBJECTIVES: The aim of this study was to define the variability of maximal wall thickness (MWT) measurements across modalities and predict its impact on care in patients with hypertrophic cardiomyopathy (HCM). BACKGROUND: Left ventricular MWT measured by echocardiography or cardiovascular magnetic resonance (CMR) contributes to the diagnosis of HCM, stratifies risk, and guides key decisions, including whether to place an implantable cardioverter-defibrillator (ICD)...
June 16, 2021: JACC. Cardiovascular Imaging
#14
JOURNAL ARTICLE
Andreas Seraphim, Kristopher D Knott, Anne-Marie Beirne, Joao B Augusto, Katia Menacho, Jessica Artico, George Joy, Rebecca Hughes, Anish N Bhuva, Ryo Torii, Hui Xue, Thomas A Treibel, Rhodri Davies, James C Moon, Daniel A Jones, Peter Kellman, Charlotte Manisty
BACKGROUND: Quantitative myocardial perfusion mapping using cardiovascular magnetic resonance (CMR) is validated for myocardial blood flow (MBF) estimation in native vessel coronary artery disease (CAD). Following coronary artery bypass graft (CABG) surgery, perfusion defects are often detected in territories supplied by the left internal mammary artery (LIMA) graft, but their interpretation and subsequent clinical management is variable. METHODS: We assessed myocardial perfusion using quantitative CMR perfusion mapping in 38 patients with prior CABG surgery, all with angiographically-proven patent LIMA grafts to the left anterior descending coronary artery (LAD) and no prior infarction in the LAD territory...
June 17, 2021: Journal of Cardiovascular Magnetic Resonance
#15
JOURNAL ARTICLE
Natalia A Ojrzyńska-Witek, Anish N Bhuva, James Connelly, Leon J Moon, James C Menezes, Charlotte H Manisty
No abstract text is available yet for this article.
May 26, 2021: Polish Archives of Internal Medicine
#16
JOURNAL ARTICLE
Christopher Pieri, Anish Bhuva, Russell Moralee, Aderonke Abiodun, Deepa Gopalan, Giles H Roditi, James C Moon, Charlotte Manisty
OBJECTIVE: To determine provision of MRI for patients with cardiac implantable electronic devices (CIEDs; pacemakers and defibrillators) in England, to understand regional variation and assess the impact of guideline changes. METHODS: Retrospective data related to MRI scans performed in patients with CIED over the preceding 12 months was collected using a structured survey tool distributed to every National Health Service Trust MRI unit in England. Data were compared with similar data from 2014/2015 and with demand (estimated from local CIED implantation rates and regional population data by sustainability and transformation partnerships (STPs))...
May 2021: Open Heart
#17
JOURNAL ARTICLE
Andreas Seraphim, Kristopher D Knott, Katia Menacho, Joao B Augusto, Rhodri Davies, Iain Pierce, George Joy, Anish N Bhuva, Hui Xue, Thomas A Treibel, Jackie A Cooper, Steffen E Petersen, Marianna Fontana, Alun D Hughes, James C Moon, Charlotte Manisty, Peter Kellman
OBJECTIVES: The purpose of this study was to explore the prognostic significance of PTT and PBVi using an automated, inline method of estimation using CMR. BACKGROUND: Pulmonary transit time (PTT) and pulmonary blood volume index (PBVi) (the product of PTT and cardiac index), are quantitative biomarkers of cardiopulmonary status. The development of cardiovascular magnetic resonance (CMR) quantitative perfusion mapping permits their automated derivation, facilitating clinical adoption...
May 12, 2021: JACC. Cardiovascular Imaging
#18
JOURNAL ARTICLE
George Joy, Jessica Artico, Hibba Kurdi, Andreas Seraphim, Clement Lau, George D Thornton, Marta Fontes Oliveira, Robert Daniel Adam, Nikoo Aziminia, Katia Menacho, Liza Chacko, James T Brown, Rishi K Patel, Hunain Shiwani, Anish Bhuva, Joao B Augusto, Mervyn Andiapen, Aine McKnight, Mahdad Noursadeghi, Iain Pierce, Timothée Evain, Gabriella Captur, Rhodri H Davies, John P Greenwood, Marianna Fontana, Peter Kellman, Erik B Schelbert, Thomas A Treibel, Charlotte Manisty, James C Moon
OBJECTIVES: The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection. BACKGROUND: Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. METHODS: Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21...
May 5, 2021: JACC. Cardiovascular Imaging
#19
JOURNAL ARTICLE
Direct in vivo assessment of global and regional mechanoelectric feedback in the intact human heart.
Michele Orini, Peter Taggart, Anish Bhuva, Neil Roberts, Carmelo Di Salvo, Martin Yates, Sveeta Badiani, Stefan Van Duijvenboden, Guy Lloyd, Andrew Smith, Pier D Lambiase
BACKGROUND: Inhomogeneity of ventricular contraction is associated with sudden cardiac death, but the underlying mechanisms are unclear. Alterations in cardiac contraction impact electrophysiological parameters through mechanoelectric feedback. This has been shown to promote arrhythmias in experimental studies, but its effect in the in vivo human heart is unclear. OBJECTIVE: The purpose of this study was to quantify the impact of regional myocardial deformation provoked by a sudden increase in ventricular loading (aortic occlusion) on human cardiac electrophysiology...
August 2021: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#20
COMPARATIVE STUDY
João B Augusto, Rhodri H Davies, Anish N Bhuva, Kristopher D Knott, Andreas Seraphim, Mashael Alfarih, Clement Lau, Rebecca K Hughes, Luís R Lopes, Hunain Shiwani, Thomas A Treibel, Bernhard L Gerber, Christian Hamilton-Craig, Ntobeko A B Ntusi, Gianluca Pontone, Milind Y Desai, John P Greenwood, Peter P Swoboda, Gabriella Captur, João Cavalcante, Chiara Bucciarelli-Ducci, Steffen E Petersen, Erik Schelbert, Charlotte Manisty, James C Moon
BACKGROUND: Left ventricular maximum wall thickness (MWT) is central to diagnosis and risk stratification of hypertrophic cardiomyopathy, but human measurement is prone to variability. We developed an automated machine learning algorithm for MWT measurement and compared precision (reproducibility) with that of 11 international experts, using a dataset of patients with hypertrophic cardiomyopathy. METHODS: 60 adult patients with hypertrophic cardiomyopathy, including those carrying hypertrophic cardiomyopathy gene mutations, were recruited at three institutes in the UK from August, 2018, to September, 2019: Barts Heart Centre, University College London Hospital (The Heart Hospital), and Leeds Teaching Hospitals NHS Trust...
January 2021: The Lancet. Digital health
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