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Anish Bhuva

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https://www.readbyqxmd.com/read/29617988/myocardial-native-t1-and-extracellular-volume-with-healthy-ageing-and-gender
#1
Stefania Rosmini, Heerajnarain Bulluck, Gabriella Captur, Thomas A Treibel, Amna Abdel-Gadir, Anish N Bhuva, Veronica Culotta, Ahmed Merghani, Marianna Fontana, Viviana Maestrini, Anna S Herrey, Kelvin Chow, Richard B Thompson, Stefan K Piechnik, Peter Kellman, Charlotte Manisty, James C Moon
Aims: To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging and to inform on normal reference ranges. Methods and results: Ninety-four healthy volunteers with no a history or symptoms of cardiovascular disease or diabetes underwent cardiovascular magnetic resonance at 1.5 T. Mid-ventricular short axis native and post-contrast T1 maps by Shortened MOdified Look-Locker Inversion-recovery (ShMOLLI), MOdified Look-Locker Inversion Recovery (MOLLI) [pre-contrast: 5s(3s)3s, post-contrast: 4s(1s)3s(1s)2s] and saturation recovery single-shot acquisition (SASHA) were acquired and ECV by these three techniques were derived for the mid anteroseptum...
March 30, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29471937/reverse-myocardial-remodeling-following-valve-replacement-in-patients-with-aortic-stenosis
#2
Thomas A Treibel, Rebecca Kozor, Rebecca Schofield, Giulia Benedetti, Marianna Fontana, Anish N Bhuva, Amir Sheikh, Begoña López, Arantxa González, Charlotte Manisty, Guy Lloyd, Peter Kellman, Javier Díez, James C Moon
BACKGROUND: Left ventricular (LV) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis). OBJECTIVES: This study sought to investigate whether human myocardial interstitial fibrosis in aortic stenosis (AS) is plastic and can regress. METHODS: Patients with symptomatic, severe AS (n = 181; aortic valve area index 0.4 ± 0.1 cm2 /m2 ) were assessed pre-aortic valve replacement (AVR) by echocardiography (AS severity, diastology), cardiovascular magnetic resonance (CMR) (for volumes, function, and focal or diffuse fibrosis), biomarkers (N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T), and the 6-min walk test...
February 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29116176/redefining-viability-by-cardiovascular-magnetic-resonance-in-acute-st-segment-elevation-myocardial-infarction
#3
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Daniel S Knight, Sabrina Nordin, Alex Sirker, Anna S Herrey, Charlotte Manisty, James C Moon, Derek J Hausenloy
In chronic myocardial infarction (MI), segments with a transmural extent of infarct (TEI) of ≤50% are defined as being viable. However, in the acute phase of an ST-segment elevation myocardial infarction (STEMI), late gadolinium enhancement (LGE) has been demonstrated to overestimate MI size and TEI. We aimed to identify the optimal cut-off of TEI by cardiovascular magnetic resonance (CMR) for defining viability during the acute phase of an MI, using ≤50% TEI at follow-up as the reference standard. 40 STEMI patients reperfused by primary percutaneous coronary intervention (PPCI) underwent a CMR at 4 ± 2 days and 5 ± 2 months...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285594/defining-left-ventricular-remodeling-following-acute-st-segment-elevation-myocardial-infarction-using-cardiovascular-magnetic-resonance
#4
Heerajnarain Bulluck, Yun Yun Go, Gabriele Crimi, Andrew J Ludman, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Silvia Pica, Claudia Raineri, Alex Sirker, Anna S Herrey, Charlotte Manisty, Ashley Groves, James C Moon, Derek J Hausenloy
BACKGROUND: The assessment of post-myocardial infarction (MI) left ventricular (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses criteria defined by echocardiography. Our aim was to provide CMR criteria for assessing LV remodeling following acute MI. METHODS: Firstly, 40 reperfused ST-segment elevation myocardial infarction (STEMI) patients with paired acute (4 ± 2 days) and follow-up (5 ± 2 months) CMR scans were analyzed by 2 independent reviewers and the minimal detectable changes (MDCs) for percentage change in LV end-diastolic volume (%ΔLVEDV), LV end-systolic volume (%ΔLVESV), and LV ejection fraction (%ΔLVEF) between the acute and follow-up scans were determined...
March 13, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28199043/diagnostic-performance-of-t1-and-t2-mapping-to-detect-intramyocardial-hemorrhage-in-reperfused-st-segment-elevation-myocardial-infarction-stemi-patients
#5
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Esther Gonzalez-Lopez, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna S Herrey, Charlotte Manisty, Derek M Yellon, James C Moon, Derek J Hausenloy
PURPOSE: To investigate the performance of T1 and T2 mapping to detect intramyocardial hemorrhage (IMH) in ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI). MATERIALS AND METHODS: Fifty STEMI patients were prospectively recruited between August 2013 and July 2014 following informed consent. Forty-eight patients completed a 1.5T cardiac magnetic resonance imaging (MRI) with native T1 , T2 , and T2* maps at 4 ± 2 days...
September 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28008358/impact-of-microvascular-obstruction-on-semiautomated-techniques-for-quantifying-acute-and-chronic-myocardial-infarction-by-cardiovascular-magnetic-resonance
#6
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Shane Weinmann, Alex Sirker, Anna S Herrey, Charlotte Manisty, James C Moon, Derek J Hausenloy
AIMS: The four most promising semiautomated techniques (5-SD, 6-SD, Otsu and the full width half maximum (FWHM)) were compared in paired acute and follow-up cardiovascular magnetic resonance (CMR), taking into account the impact of microvascular obstruction (MVO) and using automated extracellular volume fraction (ECV) maps for reference. Furthermore, their performances on the acute scan were compared against manual myocardial infarct (MI) size to predict adverse left ventricular (LV) remodelling (≥20% increase in end-diastolic volume)...
2016: Open Heart
https://www.readbyqxmd.com/read/27894068/residual-myocardial-iron-following-intramyocardial-hemorrhage-during-the-convalescent-phase-of-reperfused-st-segment-elevation-myocardial-infarction-and-adverse-left-ventricular-remodeling
#7
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Steven K White, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna S Herrey, Charlotte Manisty, Derek M Yellon, Peter Kellman, James C Moon, Derek J Hausenloy
BACKGROUND: The presence of intramyocardial hemorrhage (IMH) in ST-segment-elevation myocardial infarction patients reperfused by primary percutaneous coronary intervention has been associated with residual myocardial iron at follow-up, and its impact on adverse left ventricular (LV) remodeling is incompletely understood and is investigated here. METHODS AND RESULTS: Forty-eight ST-segment-elevation myocardial infarction patients underwent cardiovascular magnetic resonance at 4±2 days post primary percutaneous coronary intervention, of whom 40 had a follow-up scan at 5±2 months...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27402229/automated-extracellular-volume-fraction-mapping-provides-insights-into-the-pathophysiology-of-left-ventricular-remodeling-post-reperfused-st-elevation-myocardial-infarction
#8
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Steven K White, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Esther Gonzalez-Lopez, Patricia Reant, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna S Herrey, Charlotte Manisty, Derek M Yellon, Peter Kellman, James C Moon, Derek J Hausenloy
BACKGROUND: Whether the remote myocardium of reperfused ST-segment elevation myocardial infarction (STEMI) patients plays a part in adverse left ventricular (LV) remodeling remains unclear. We aimed to use automated extracellular volume fraction (ECV) mapping to investigate whether changes in the ECV of the remote (ECVR emote) and infarcted myocardium (ECVI nfarct) impacted LV remodeling. METHODS AND RESULTS: Forty-eight of 50 prospectively recruited reperfused STEMI patients completed a cardiovascular magnetic resonance at 4±2 days and 40 had a follow-up scan at 5±2 months...
July 11, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26762875/automatic-measurement-of-the-myocardial-interstitium-synthetic-extracellular-volume-quantification-without-hematocrit-sampling
#9
MULTICENTER STUDY
Thomas A Treibel, Marianna Fontana, Viviana Maestrini, Silvia Castelletti, Stefania Rosmini, Joanne Simpson, Arthur Nasis, Anish N Bhuva, Heerajnarain Bulluck, Amna Abdel-Gadir, Steven K White, Charlotte Manisty, Bruce S Spottiswoode, Timothy C Wong, Stefan K Piechnik, Peter Kellman, Matthew D Robson, Erik B Schelbert, James C Moon
OBJECTIVES: The authors sought to generate a synthetic extracellular volume fraction (ECV) from the relationship between hematocrit and longitudinal relaxation rate of blood. BACKGROUND: ECV quantification by cardiac magnetic resonance (CMR) measures diagnostically and prognostically relevant changes in the extracellular space. Current methodologies require blood hematocrit (Hct) measurement-a complication to easy clinical application. We hypothesized that the relationship between Hct and longitudinal relaxation rate of blood (R1 = 1/T1blood) could be calibrated and used to generate a synthetic ECV without Hct that was valid, user-friendly, and prognostic...
January 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/26264813/t1-mapping-and-t2-mapping-at-3t-for-quantifying-the-area-at-risk-in-reperfused-stemi-patients
#10
Heerajnarain Bulluck, Steven K White, Stefania Rosmini, Anish Bhuva, Thomas A Treibel, Marianna Fontana, Amna Abdel-Gadir, Anna Herrey, Charlotte Manisty, Simon M Y Wan, Ashley Groves, Leon Menezes, James C Moon, Derek J Hausenloy
BACKGROUND: Whether T1-mapping cardiovascular magnetic resonance (CMR) can accurately quantify the area-at-risk (AAR) as delineated by T2 mapping and assess myocardial salvage at 3T in reperfused ST-segment elevation myocardial infarction (STEMI) patients is not known and was investigated in this study. METHODS: 18 STEMI patients underwent CMR at 3T (Siemens Bio-graph mMR) at a median of 5 (4-6) days post primary percutaneous coronary intervention using native T1 (MOLLI) and T2 mapping (WIP #699; Siemens Healthcare, UK)...
August 12, 2015: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/25418759/t1-mapping-non-invasive-evaluation-of-myocardial-tissue-composition-by-cardiovascular-magnetic-resonance
#11
REVIEW
Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Anna S Herrey, Charlotte H Manisty, James C Moon
Cardiovascular magnetic resonance is an important tool for patient care and is the best test for myocardial structure and function. Ischemia and scar imaging also provide key insights and focus attention on heart muscle - the site of most cardiac diseases. New ways of measuring abnormal muscle have been developed, including T1 mapping. Abnormal signal can be distinguished either without contrast (native T1), or post-contrast (extracellular volume measurement). Large changes occur in rare diseases (cardiac amyloidosis, Anderson-Fabry disease and iron overload) even at an early stage, while more subtle changes are seen in diffuse fibrosis where a robust test would be of major impact...
December 2014: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/22042754/a-34-year-old-man-with-bilateral-anterior-uveitis-and-a-rash
#12
Anish N Bhuva, Harpreet K Lota
No abstract text is available yet for this article.
2011: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/19590590/anteroposterior-diameter-of-the-infrarenal-abdominal-aorta-is-higher-in-women-with-polycystic-ovary-syndrome
#13
Marco Matteo Ciccone, Stefano Favale, Anish Bhuva, Pietro Scicchitano, Vito Caragnano, Cristina Lavopa, Giovanni De Pergola, Giuseppe Loverro
BACKGROUND: Women affected by polycystic ovary syndrome (PCOS) are known to be at higher risk of cardiovascular disease. The aim of this study was to identify the artery that first is affected by early pre-atherosclerotic changes in PCOS. METHODS: Twenty-nine women with PCOS aged 17 to 27 years and 26 healthy nonhyperandrogenic volunteers with regular menses (control women) aged 16 to 28 years were enrolled. All PCOS patients were overweight or obese (body mass index [BMI] > or = 25)...
2009: Vascular Health and Risk Management
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