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https://www.readbyqxmd.com/read/29344690/-globalization-challenges-in-abdominal-surgery-for-migrants-and-refugees
#1
REVIEW
T J Wilhelm, S Post
The increasing number of refugees, migrants and international travelers influences the surgical spectrum of abdominal diseases. The aim of this review is to familiarize surgeons with specific diseases which are endemic in the patients' countries of origin and are likely to be diagnosed with increasing incidence in Germany. Low levels of hygiene in the countries of origin or refugee camps is associated with a high incidence of numerous infections, such as helminth infections, typhoid fever or amoebiasis, which if untreated can cause surgical emergencies...
January 17, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29327530/splenic-abscess-caused-by-salmonella-typhi-and-co-infection-with-leptospira
#2
Monalisa Sahu, Arvind Kumar, Neeraj Nischal, B G Bharath, Smita Manchanda, Naveet Wig
Splenic abscesses caused by Salmonella typhi are a very rare complication of typhoid fever in this era of use of specific antibiotics. Co-infection with Leptospira in such a patient is even rarer. Clinical diagnosis of splenic abscess caused by Salmonella is difficult owing to its rarity, being insidious in onset and having nonspecific clinical presentation. Splenic abscesses are potentially fatal complication of typhoid fever. In most of these patients, hemoglobinopathies or some other underlying immunocompromised state is usually present...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29324231/decoding-a-salmonella-typhi-regulatory-network-that-controls-typhoid-toxin-expression-within-human-cells
#3
Casey C Fowler, Jorge E Galán
Salmonella Typhi is the cause of typhoid fever, a major global health concern. An essential virulence factor of this pathogen is typhoid toxin. In contrast to most AB-type toxins, typhoid toxin is exclusively expressed by intracellular bacteria. The regulatory networks that ensure this unique gene expression pattern are unknown. Here, we developed FAST-INSeq, a genome-wide screening approach to identify S. Typhi genes required for typhoid toxin expression within infected cells. We find that typhoid toxin expression is controlled by a silencing and counter-silencing mechanism through the opposing actions of the PhoP/PhoQ two-component regulatory system and the histone-like protein H-NS...
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29317704/biofilm-formation-protects-salmonella-from-the-antibiotic-ciprofloxacin-in-vitro-and-in-vivo-in-the-mouse-model-of-chronic-carriage
#4
Juan F González, Halley Alberts, Joel Lee, Lauren Doolittle, John S Gunn
Typhoid fever is caused by the human-restricted pathogen Salmonella enterica sv. Typhi. Approximately 5% of people that resolve the disease become chronic carriers, with the gallbladder as the main reservoir of the bacteria. Of these, about 90% present with gallstones, on which Salmonella form biofilms. Because S. Typhi is a human-restricted pathogen, these carriers are the main source of dissemination of the disease; unfortunately, antibiotic treatment has shown to be an ineffective therapy. This is believed to be caused by the inherent antibiotic resistance conferred by Salmonella biofilms growing on gallstones...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29302648/incidence-of-malaria-typhoid-co-infection-among-adult-population-in-unwana-community-afikpo-north-local-government-area-ebonyi-state-southeastern-nigeria
#5
O O Odikamnoro, I M Ikeh, F N Okoh, S C Ebiriekwe, I A Nnadozie, J O Nkwuda, G C Asobie
Background: Malaria and typhoid fever are two leading infections of poverty with serious health and socioeconomic impacts, and due to their geographical overlap, co-infections are very common. Their mimicking symptomatology often present with gross misdiagnosis and mistreatment. This study was carried out to determine the incidence of malaria and typhoid co-infections among adult population in Unwana Community, Afikpo-North Local Government Area of Ebonyi State. Materials and Methods: Three hundred and fifty (350) individuals were examined, their blood samples subjected to microscopic examination and widal agglutination tests, for identification of Plasmodium parasites and antibodies to Salmonella enterica serovar typhi respectively...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29287062/the-influence-of-conjugation-variables-on-the-design-and-immunogenicity-of-a-glycoconjugate-vaccine-against-salmonella-typhi
#6
M Arcuri, R Di Benedetto, A F Cunningham, A Saul, C A MacLennan, F Micoli
In recent years there have been major efforts to develop glycoconjugate vaccines based on the Vi polysaccharide that will protect against Salmonella enterica Typhi infections, particularly typhoid fever, which remains a major public health concern in low-income countries. The design of glycoconjugate vaccines influences the immune responses they elicit. Here we systematically test the response in mice to Vi glycoconjugates that differ in Vi chain length (full-length and fragmented), carrier protein, conjugation chemistry, saccharide to protein ratio and size...
2017: PloS One
https://www.readbyqxmd.com/read/29279484/typhoid-vaccination-among-japanese-travelers-to-south-asia-and-the-factors-associated-with-compliance
#7
Kenichiro Yaita, Koji Yahara, Nobuyuki Hamada, Yoshiro Sakai, Jun Iwahashi, Kenji Masunaga, Hiroshi Watanabe
Objective In 2010, candid advice concerning the low rate of typhoid vaccination among Japanese travelers was received from Nepal. Recently, progressive Japanese travel clinics have encouraged Japanese travelers to be vaccinated against typhoid fever in conjunction with officially approved vaccines, such as hepatitis A vaccine. We herein report the status of typhoid vaccinations for Japanese travelers to the most endemic area (South Asia) and describe the factors associated with compliance. Methods In the travel clinic at Kurume University Hospital, we used the following criteria to retrospectively extract the records of new pre-travel Japanese clients between January 2011 and March 2015: hepatitis A vaccine administered, traveling to South Asian countries, and ≥2 years of age...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29277466/determinants-of-postoperative-morbidity-and-mortality-in-children-managed-for-typhoid-intestinal-perforation-in-kano-nigeria
#8
Lofty-John Anyanwu, Aminu Mohammad, Lawal Abdullahi, Aliyu Farinyaro, Stephen Obaro
BACKGROUND: Intestinal perforation is a serious but poorly understood complication of typhoid fever. This study aims to determine the patient factors associated with postoperative morbidity and mortality. METHODS: We retrospectively reviewed the records of all children presenting to our unit with typhoid intestinal perforation (TIP) between March 2009 and December 2013. The patients were grouped based on postoperative outcome status and were compared with respect to patient related variables, using chi square test...
December 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29276700/an-updated-view-on-the-rck-invasin-of-salmonella-still-much-to-discover
#9
REVIEW
Julien Mambu, Isabelle Virlogeux-Payant, Sébastien Holbert, Olivier Grépinet, Philippe Velge, Agnès Wiedemann
Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threat to public health. A key step in Salmonella pathogenesis is the invasion of phagocytic and non-phagocytic host cells. To trigger its own internalization into non-phagocytic cells, Salmonella has developed different mechanisms, involving several invasion factors...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29272995/primary-care-challenges-of-an-obscure-case-of-alice-in-wonderland-syndrome-in-a-patient-with-severe-malaria-in-a-resource-constrained-setting-a-case-report
#10
Benjamin Momo Kadia, Cyril Jabea Ekabe, Ettamba Agborndip
BACKGROUND: "Alice in Wonderland" syndrome (AIWS) is a rare neurological abnormality characterized by distortions of visual perceptions, body schema and experience of time. AIWS has been reported in patients with various infections such as infectious mononucleosis, H1N1 influenza, Cytomegalovirus encephalitis, and typhoid encephalopathy. However, AIWS occurring in a patient with severe malaria is less familiar and could pose serious primary care challenges in a low-income context. CASE PRESENTATION: A 9-year-old male of black African ethnicity was brought by his parents to our primary care hospital because for 2 days he had been experiencing intermittent sudden perceptions of his parents' heads and objects around him either "shrinking" or "expanding"...
December 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29230887/integration-of-molecular-dynamics-simulation-and-hotspot-residues-grafting-for-de-novo-scfv-design-against-salmonella-typhi-tolc-protein
#11
Siew Wen Leong, Theam Soon Lim, Asma Ismail, Yee Siew Choong
With the development of de novo binders for protein targets from non-related scaffolds, many possibilities for therapeutics and diagnostics have been created. In this study, we described the use of de novo design approach to create single-chain fragment variable (scFv) for Salmonella enterica subspecies enterica serovar Typhi TolC protein. Typhoid fever is a global health concern in developing and underdeveloped countries. Rapid typhoid diagnostics will improve disease management and therapy. In this work, molecular dynamics simulation was first performed on a homology model of TolC protein in POPE membrane bilayer to obtain the central structure that was subsequently used as the target for scFv design...
December 12, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29229736/comparison-of-salmonella-enterica-serovars-typhi-and-typhimurium-reveals-typhoidal-specific-responses-to-bile
#12
Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel
Salmonella enterica serovars Typhi and Typhimurium cause typhoid fever and gastroenteritis respectively. A unique feature of typhoid infection is asymptomatic carriage within the gallbladder, which is linked with S Typhi transmission. Despite this, S Typhi responses to bile have been poorly studied. RNA-Seq of S Typhi Ty2 and a clinical S Typhi isolate belonging to the globally dominant H58 lineage (129-0238), as well as S Typhimurium 14028, revealed that 249, 389 and 453 genes respectively were differentially expressed in the presence of 3% bile compared to control cultures lacking bile...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29217701/signet-ring-histiocytes-in-typhoid-fever
#13
Jianfeng Zhu, Wei Guo
No abstract text is available yet for this article.
December 7, 2017: Blood
https://www.readbyqxmd.com/read/29205191/investigation-into-a-community-outbreak-of-salmonella-typhi-in-bengaluru-india
#14
Swathi Purighalla, Saritha Esakimuthu, Mallika Reddy, Tara Seth, Sunita D Patil, George K Varghese, Raghunath Dasarathy, Vijay S Richard, Vasan K Sambandamurthy
BACKGROUND & OBJECTIVES: Outbreaks of infection due to Salmonella enterica servovar Typhi (S. Typhi) are a great threat to public health. A rapid molecular typing method to characterize strains implicated in an outbreak is critical in implementing appropriate control measures. This study was done to demonstrate the power of a PCR-based method to provide rapid insights into the genetic relatedness amongst the Salmonella isolates implicated in a suspected typhoid fever outbreak. METHODS: Forty two S...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29205190/characterization-of-antimicrobial-resistance-markers-their-stability-in-salmonella-enterica-serovar-typhi
#15
Yashwant Kumar, Anshu Sharma, Kavaratty Raju Mani
BACKGROUND & OBJECTIVES: Typhoid fever is a major cause of morbidity and mortality in the developing countries including India. Resistance to multiple antimicrobial agents is an emerging global problem that has serious impact on the treatment of disease. There are many factors associated with the emergence of resistance. Most important of them is the acquisition and further transmission and spread of resistance markers among various bacterial species. Therefore, we conducted this study to characterize the resistance plasmids in terms of their transferability and stability among Salmonella enterica serovar Typhi...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29203881/in-vivo-tropism-of-salmonella-typhi-toxin-to-cells-expressing-a-multiantennal-glycan-receptor
#16
Yi-An Yang, Sohyoung Lee, Jun Zhao, Andrew J Thompson, Ryan McBride, Buyankhishig Tsogtbaatar, James C Paulson, Ruth Nussinov, Lingquan Deng, Jeongmin Song
Typhoid fever is a life-threatening disease, but little is known about the molecular bases for its unique clinical presentation. Typhoid toxin, a unique virulence factor of Salmonella Typhi (the cause of typhoid fever), recapitulates in an animal model many symptoms of typhoid fever. Typhoid toxin binding to its glycan receptor Neu5Ac is central, but, due to the ubiquity of Neu5Ac, how typhoid toxin causes specific symptoms remains elusive. Here we show that typhoid toxin displays in vivo tropism to cells expressing multiantennal glycoprotein receptors, particularly on endothelial cells of arterioles in the brain and immune cells, which is in line with typhoid symptoms...
December 4, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29201803/massive-lower-gastrointestinal-bleed-caused-by-typhoid-ulcer-conservative-management
#17
Apoorv Goel, Roli Bansal
Typhoid fever is caused by gram-negative organism Salmonella typhi. The usual presentation is high-grade fever, but complications like gastrointestinal (GI) hemorrhage and perforation are also seen frequently. With the advent of antibiotics, these complications are rarely seen now. We present a case of a young female who was admitted with a diagnosis of typhoid fever presented with a massive GI bleed from ulcers in the terminal ileum and was managed conservatively without endotherapy and surgery. How to cite this article: Goel A, Bansal R...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29191238/ethnopharmacological-studies-of-indigenous-plants-in-kel-village-neelum-valley-azad-kashmir-pakistan
#18
Khawaja Shafique Ahmad, Abdul Hamid, Fahim Nawaz, Mansoor Hameed, Farooq Ahmad, Jiabin Deng, Noreen Akhtar, Ambreen Wazarat, Sehrish Mahroof
BACKGROUND: This explorative study was undertaken for the first time in Kel village located in the Upper Neelum Valley, Azad Kashmir, Pakistan. The purpose was to document the indigenous knowledge of the native people used in the preparation of herbal medicines. METHODS: To get the data on traditional uses of medicinal plants, 20 informants were interviewed. Quantitative ethnobotanical indices, i.e., use value (UV), relative frequencies of citation (RFC), informant consensus factor (Fic), fidelity level (FL), data matrix ranking (DMR), preference ranking (PR), and jaccard index (JI), were calculated for the recorded medicinal plants...
December 1, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29184606/knowledge-attitude-and-practice-of-hygiene-and-sanitation-in-a-burundian-refugee-camp-implications-for-control-of-a-salmonella-typhi-outbreak
#19
Marie-Rosette Nahimana, Candide Tran Ngoc, Olushayo Olu, Jose Nyamusore, Ayodeji Isiaka, Vedaste Ndahindwa, Lakruwan Dassanayake, André Rusanganwa
Introduction: A Salmonella typhi outbreak was reported in a Burundian refugee camp in Rwanda in October 2015. Transmission persisted despite increased hygiene promotion activities and hand-washing facilities instituted to prevent and control the outbreak. A knowledge, attitude and practice (KAP) study was carried out to assess the effectiveness of ongoing typhoid fever preventive interventions. Methods: A cross-sectional survey was conducted in Mahama Refugee Camp of Kirehe District, Rwanda from January to February 2016...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29180411/correction-for-alvarez-et-al-human-genetic-variation-in-vac14-regulates-salmonella-invasion-and-typhoid-fever-through-modulation-of-cholesterol
#20
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
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