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https://www.readbyqxmd.com/read/29239241/tuberculous-spondylitis-after-vertebral-augmentation-a-case-report-with-a-literature-review
#1
Sun Jia-Jia, Sun Zhi-Yong, Qian Zhong-Lai, Yang Hui-Lin, Zhu Xiao-Yu
Tuberculous spondylitis of vertebral augmentation following percutaneous vertebroplasty or kyphoplasty is rare. We report an unusual case of tuberculous spondylitis diagnosed after percutaneous kyphoplasty (PKP). A 54-year-old woman presented to hospital complaining of back pain following a fall 20 days prior. Radiology showed an acute osteoporotic compression (L3 fracture). The patient denied a history of pulmonary tuberculosis and there were no signs of infection. The patient was discharged from hospital 2 days after undergoing L3 PKP with a dramatic improvement in her back pain...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29237505/1-25-dihydroxyvitamin-d3-modulates-the-phenotype-and-function-of-monocyte-derived-dendritic-cells-in-cattle
#2
Yolanda Corripio-Miyar, Richard J Mellanby, Katy Morrison, Tom N McNeilly
BACKGROUND: The active form of the vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) has been shown to have major effects not only on physiological processes but also on the regulation of the immune system of vertebrates. Dendritic cells are specialised antigen presenting cells which are in charge of the initiation of T-cell dependant immune responses and as such are key regulators of responses towards pathogens. In this study we set out to evaluate the effects of 1,25-(OH)2D3 on the phenotype of cattle monocyte-derived dendritic cells (MoDCs) and how the conditioning with this vitamin affects the function of these myeloid cells...
December 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29237100/perianal-tuberculosis-in-an-immunocompetent-patient
#3
Gabriela Mosena, Andréia Della Giustina Pires, Jessica Matos D'Almeida Santos, Joel Schwartz, Josué Victorino
Tuberculosis (TB) is a major public health problem worldwide, considered to be the main cause of death from infectious diseases, ranking alongside HIV infection. Skin involvement occurs in 1.5% of the cases, and perianal involvement is extremely rare and tends to occur among immunocompromised patients. Due to its heterogeneous clinical presentation, the diagnosis of cutaneous TB is challenging, requiring a high level of suspicion. This article is protected by copyright. All rights reserved.
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29236840/clinical-information-systems-for-the-management-of-tuberculosis-in-primary-health-care
#4
Eliabe Rodrigues de Medeiros, Sandy Yasmine Bezerra E Silva, Cáthia Alessandra Varela Ataide, Erika Simone Galvão Pinto, Maria de Lourdes Costa da Silva, Tereza Cristina Scatena Villa
OBJECTIVE: to analyze the clinical information systems used in the management of tuberculosis in Primary Health Care. METHOD: descriptive, quantitative cross-sectional study with 100 health professionals with data collected through a questionnaire to assess local institutional capacity for the model of attention to chronic conditions, as adapted for tuberculosis care. The analysis was performed through descriptive and inferential statistics. RESULTS: Nurses and the Community Health Agents were classified as having fair capacity with a mean of 6...
December 11, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29236768/autophagy-induction-by-mycobacterium-indicus-pranii-promotes-mycobacterium-tuberculosis-clearance-from-raw-264-7-macrophages
#5
Bindu Singh, Mohd Saqib, Ananya Gupta, Pawan Kumar, Sangeeta Bhaskar
Mycobacterium indicus pranii (MIP) is a potent vaccine candidate against tuberculosis (TB) as it has demonstrated significant protection in animal models of tuberculosis as well as in clinical trials. Higher protective efficacy of MIP against TB as compared to BCG provoked the efforts to gain insight into the molecular mechanisms underlying MIP mediated protection against Mycobacterium tuberculosis (M.tb). Autophagy, initially described as a cell survival mechanism during starvation, also plays a key role in host resistance to M...
2017: PloS One
https://www.readbyqxmd.com/read/29235156/ifn-%C3%AE-against-the-38-kda-antigen-of-mycobacterium-tuberculosis-discriminates-pulmonary-tuberculosis-from-infection-and-infection-from-exposure-evidence-from-a-study-of-human-population-in-a-high-endemic-setting
#6
Fekadu Abebe, Mulugeta Belay, Mengistu Legesse
Mycobacterium tuberculosis (Mtb) 38-kDa antigen is an immunogenic lipoprotein that induces strong T-cell responses in experimental animals. However, there is limited information on the role of this antigen in human population. In this article, we present the dynamics of pro-inflammatory (IFN-γ and TNF-α) and anti-inflammatory cytokine (IL-10) against the 38 kDa in cohorts of pulmonary TB (PTB) patients, household contacts (HHCs), and community controls (CCs) in a high endemic setting. Whole blood assay was used to determine the levels of cytokines in 149 patients, 149 HHCs, and 68 CCs at baseline, 6 months, and 12 months...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29234660/monosegmental-combined-anterior-posterior-instrumentation-for-the-treatment-of-a-severe-lumbar-tuberculous-spondylodiscitis-case-report-and-literature-review
#7
Petracchi Matias, Camino Willhuber Gaston, Tripodi Maria, Bassani Julio, Gruenberg Marcelo, Sola Carlos
Spinal tuberculosis (Pott disease) can produce severe deformities when it is not properly treated. Long instrumentations through single or combined double approaches are usually required to prevent and correct the deformity. The authors present a case of severe deformity secondary to tuberculous spondylodiscitis in the lumbar spine treated with a monosegmental instrumentation through a double approach in a patient with idiopathic scoliosis. Deformity correction and infection resolution through debridement and arthrodesis is observed after one year of follow-up...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234108/mother-to-newborn-transmission-of-mycobacterial-l-forms-and-v%C3%AE-2-t-cell-response-in-placentobiome-of-bcg-vaccinated-pregnant-women
#8
T Dimova, A Terzieva, L Djerov, V Dimitrova, A Nikolov, P Grozdanov, N Markova
The ability of bacteria to exist as a population of self-replicating forms with defective or entirely missing cell wall (L-forms) is an adaptive mechanism for their survival and reproduction under unfavorable conditions. Bacterial mother-to-fetus transfer is a universal phenomenon in the animal kingdom. However, data about vertical transfer of L bacterial forms are extremely scarce. Bacille Calmette-Guérin is an attenuated strain of M. bovis and the only licensed vaccine used for tuberculosis prevention. We already have shown that filterable L-forms of BCG exist freely in the vaccine and are able to reproduce and to form colonies...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232638/engineering-a-self-sufficient-mycobacterium-tuberculosis-cyp130-by-gene-fusion-with-the-reductase-domain-of-cyp102a1-from-bacillus-megaterium
#9
Sandra Ortega Ugalde, Rosa A Luirink, Daan P Geerke, Nico P E Vermeulen, Wilbert Bitter, Jan N M Commandeur
CYP130 belongs to the subset of cytochrome P450s from Mycobacterium tuberculosis (Mtb) that have been structurally characterized. Despite several efforts for its functional characterization, CYP130 is still considered an orphan enzyme for which no endogenous or exogenous substrate has been identified. In addition, functional redox-partners for CYP130 have not been clearly established yet, hampering the elucidation of its physiological role. In the present study, a catalytically active fusion protein involving CYP130 and the NADPH reductase-domain of CYP102A1 from Bacillus megaterium was created...
December 7, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29232189/a-rare-cause-of-hypophysitis-tuberculosis
#10
Ihsan Ates, B Katipoglu, B Copur, N Yilmaz
OBJECTIVES: Hypophysitis is a heterogeneous inflammatory disease of pituitary gland. As it causes headache and visual defects, it mimics sellar tumors in clinical and radiological aspects. It may occur due to primary or secondary causes. Tuberculosis is one of the rare secondary causes of the hypophysitis. Subject and Results. A 30-year-old male patient presented with fatigue and headache. Panhypopituitarism was considered due to the results and the diagnostic magnetic resonance (MR) imaging revealed sagittal section diamater of pituitary gland higher than normal...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29230211/evaluation-of-aggregated-ag85b-antigen-for-its-biophysical-properties-immunogenicity-and-vaccination-potential-in-a-murine-model-of-tuberculosis-infection
#11
Faraz Ahmad, Swaleha Zubair, Pushpa Gupta, Umesh Datta Gupta, Rakesh Patel, Mohammad Owais
Protein aggregates have been reported to act as a reservoir that can release biologically active, native form of precursor protein. Keeping this fact into consideration, it is tempting to exploit protein aggregate-based antigen delivery system as a functional vaccine to expand desirable immunological response in the host. Herein, we explored the capacity of aggregated Ag85B of Mycobacterium tuberculosis (Mtb) to act as a prophylactic vaccine system that releases the precursor antigen in slow and sustained manner...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29229639/whole-cell-screen-of-fragment-library-identifies-gut-microbiota-metabolite-indole-propionic-acid-as-antitubercular
#12
Dereje A Negatu, Joe J J Liu, Matthew Zimmerman, Firat Kaya, Véronique Dartois, Courtney C Aldrich, Martin Gengenbacher, Thomas Dick
Several key tuberculosis drugs including pyrazinamide, with a molecular weight of 123.1 g/mol, are smaller than the usual drug like molecules. Current drug discovery efforts focus on the screening of larger compounds with molecular weights centered around 400-500 g/mol. Fragment (molecular weight < 300 g/mol) libraries have not been systematically explored for antitubercular activity. Here we screened a collection of 1000 fragments, present in the Maybridge Ro3 library, for whole cell activity against Mycobacterium tuberculosis Twenty-nine primary hits showed dose-dependent growth inhibition equal or better than pyrazinamide...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29226167/mathematical-modeling-of-chronic-infectious-diseases-unpacking-the-black-box
#13
Anthony T Fojo, Emily A Kendall, Parastu Kasaie, Sourya Shrestha, Thomas A Louis, David W Dowdy
Background: Mathematical models are increasingly used to understand the dynamics of infectious diseases, including "chronic" infections with long generation times. Such models include features that are obscure to most clinicians and decision-makers. Methods: Using a model of a hypothetical active case-finding intervention for tuberculosis in India as an example, we illustrate the effects on model results of different choices for model structure, input parameters, and calibration process...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29225937/use-of-standardised-patients-to-assess-quality-of-healthcare-in-nairobi-kenya-a-pilot-cross-sectional-study-with-international-comparisons
#14
Benjamin Daniels, Amy Dolinger, Guadalupe Bedoya, Khama Rogo, Ana Goicoechea, Jorge Coarasa, Francis Wafula, Njeri Mwaura, Redemptar Kimeu, Jishnu Das
Introduction: The quality of clinical care can be reliably measured in multiple settings using standardised patients (SPs), but this methodology has not been extensively used in Sub-Saharan Africa. This study validates the use of SPs for a variety of tracer conditions in Nairobi, Kenya, and provides new results on the quality of care in sampled primary care clinics. Methods: We deployed 14 SPs in private and public clinics presenting either asthma, child diarrhoea, tuberculosis or unstable angina...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225431/insights-from-the-protein-protein-interaction-network-analysis-of-mycobacterium-tuberculosis-toxin-antitoxin-systems
#15
Zoozeal Thakur, Renu Dharra, Vandana Saini, Ajit Kumar, Promod K Mehta
Protein-protein interaction (PPI) network analysis is a powerful strategy to understand M. tuberculosis (Mtb) system level physiology in the identification of hub proteins. In the present study, the PPI network of 79 Mtb toxin-antitoxin (TA) systems comprising of 167 nodes and 234 edges was investigated. The topological properties of PPI network were examined by 'Network analyzer' a cytoscape plugin app and STRING database. The key enriched biological processes and the molecular functions of Mtb TA systems were analyzed by STRING...
2017: Bioinformation
https://www.readbyqxmd.com/read/29224732/handheld-isothermal-amplification-and-electrochemical-detection-of-dna-in-resource-limited-settings
#16
Maria-Nefeli Tsaloglou, Alex Nemiroski, Gulden Camci-Unal, Dionysios C Christodouleas, Lara P Murray, John T Connelly, George M Whitesides
This paper demonstrates a new method for electrochemical detection of specific sequences of DNA present in trace amounts in serum or blood. This method is designed for use at the point-of-care (particularly in resource-limited settings). By combining recombinase polymerase amplification (RPA)- an isothermal alternative to the polymerase chain reaction - with an electroactive mediator, this electrochemical methodology enables accurate detection of DNA in the field using a low-cost, portable electrochemical analyzer (specifically designed for this type of analysis)...
December 7, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29221545/-globalhealth-twitter-conversations-on-malaria-hiv-tb-ncds-and-ntds-a-cross-sectional-analysis
#17
Isaac Chun-Hai Fung, Ashley M Jackson, Jennifer O Ahweyevu, Jordan H Grizzle, Jingjing Yin, Zion Tsz Ho Tse, Hai Liang, Juliet N Sekandi, King-Wa Fu
BACKGROUND: Advocates use the hashtag #GlobalHealth on Twitter to draw users' attention to prominent themes on global health, to harness their support, and to advocate for change. OBJECTIVES: We aimed to describe #GlobalHealth tweets pertinent to given major health issues. METHODS: Tweets containing the hashtag #GlobalHealth (N = 157,951) from January 1, 2014, to April 30, 2015, were purchased from GNIP Inc. We extracted 5 subcorpora of tweets, each with 1 of 5 co-occurring disease-specific hashtags (#Malaria, #HIV, #TB, #NCDS, and #NTDS) for further analysis...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29221342/tuberculous-tracheobronchial-stenosis-avoiding-resection-when-less-is-more
#18
Katherine Khvilivitzky, Puja N Trivedi, P Michael McFadden
A case of tracheobronchial stenosis due to tuberculosis in a young woman is presented. Compromised pulmonary function due to near-total obstruction of the proximal left main bronchus was diagnosed. Treatment options included surgical resection, endobronchial dilation or stenting, and argon photocoagulation. An approach was chosen to address symptoms without aggressive resection or commitment to stenting. She remains monitored and, while possibly committed to future intervention, no bridges have been burned with respect to more definitive and invasive therapies...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221316/recent-advances-in-the-management-of-pulmonary-tuberculoma-with-focus-on-the-use-of-tubeless-video-assisted-thoracoscopic-surgery
#19
REVIEW
Zhaohua Xia, Kun Qiao, Jianxing He
Pulmonary tuberculoma are benign solitary pulmonary nodules representing up to 25% of all resected solitary pulmonary nodules. However, the differentiation between pulmonary tuberculoma and lung cancer, as well as between active tuberculoma and inactive tuberculoma remains a clinical challenge. The present review summarizes the recent advances in the management of pulmonary tuberculoma, including radiological findings, the response to anti-tuberculosis treatment and surgical treatments. Application of the novel tubeless video-assisted thoracoscopic surgery (VATS) technique in both the diagnosis and treatment of pulmonary tuberculoma has been found to be safe and feasible and leads to less surgical trauma, which results in reduced length of hospitalization and better post-operative quality of life...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219817/donor-derived-tuberculosis-via-orthotopic-liver-transplantation
#20
B N Ruijter, A K S van Wijngaarden, B van Hoek, M Mensen, D van Soolingen, S M Arend
We present a case of donor-derived tuberculosis after liver transplantation, in which the donor origin of the Mycobacterium tuberculosis isolate was made most likely by DNA fingerprinting. Screening for latent tuberculosis of transplant donors originating from high endemic areas with an ex-vivo interferon-gamma release assay should be considered.
November 2017: Netherlands Journal of Medicine
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