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tuberculosis presentation

Alexandre Baumgarten, Juliana B Hilgert, Ione C Pinto, Fabiana C M Zacharias, Alexandre F Bulgarelli
BACKGROUND: Tuberculosis (TB) is still a major public health problem in many countries, including Brazil. Primary health care (PHC) services are a set of important services with infrastructure and resources to diagnose, treat, and cure several diseases, including the TB.AimThe aim of this study is to analyse aspects of the facility infrastructure of Brazilian PHC, regarding the control and treatment of TB from a countrywide perspective. METHODS: This is a cross-sectional study based on PHC services...
September 17, 2018: Primary Health Care Research & Development
Gebremedhin Romha, Gebreyohans Gebru, Abrha Asefa, Gezahegne Mamo
Mycobacterium tuberculosis complex is the cause of tuberculosis (TB) in humans and other animals. Specifically, Mycobacterium bovis (M. bovis) and Mycobacterium tuberculosis (M. tuberculosis) are highly pathogenic mycobacteria that may infect different animal species and are the sources of TB in humans. The objective of this paper was to review the epidemiology of M. bovis and M. tuberculosis in animals. The review also highlighted the transmission dynamics of M. bovis and M. tuberculosis in humans and animals and control challenges of zoonotic TB in Ethiopia...
October 1, 2018: Preventive Veterinary Medicine
Philipp Kasper, Katharina Pütz, Sarah Fünger, Isabelle Suárez, Norma Jung, Hakan Alakus, Christiane Bruns, Jan Rybniker
Granulomatous peritonitis represents a rare postoperative complication that should be considered as important differential diagnosis in all patients who present to the hospital with abdominal pain, abdominal tenderness, and fever after abdominal surgery. Clinical distinction from abdominal tuberculosis remains a diagnostic challenge and requires thorough histopathological and microbiological examination.
September 2018: Clinical Case Reports
Zikun Huang, Rigu Su, Cheng Qing, Yiping Peng, Qing Luo, Junming Li
Recent studies have demonstrated that circular RNAs (circRNAs) could serve as potential molecular markers for disease diagnosis; however, little is known about their diagnostic value in active tuberculosis (TB). This study first performed a microarray screening of circRNA changes in plasma samples from 3 patients with active pulmonary TB and 3 healthy controls. Then, candidate circRNAs were selected for validation on a quantitative real-time PCR system. Of the 61 differentially expressed circRNAs recorded, 43 and 18 were upregulated and downregulated in the TB group, respectively...
2018: Frontiers in Microbiology
Xi Dai, Bin Niu, Xiao-Qiong Yang, Guo-Ping Li
INTRODUCTION: The diagnosis of tuberculous mediastinal lymphadenitis remains a challenge, and the use of transbronchoscopic needle aspiration (TBNA) combined with rapid on-site cytological evaluation (ROSE) is still unclear. A case of tuberculous mediastinal lymphadenitis was illustrated to show the diagnostic value of TBNA and ROSE. CASE PRESENTATION: In this case report, we presented a typical case of a 44-year-old male who underwent obvious odynophagia and mild symptom of dyspnea...
September 2018: Medicine (Baltimore)
Moises A Huaman, David Henson, Paola L Rondan, Eduardo Ticona, Gustavo Miranda, Richard J Kryscio, Raquel Mugruza, Ernesto Aranda, Cesar Ticona, Susan Abarca, Paula Heredia, Andres Aguirre, Timothy R Sterling, Beth A Garvy, Carl J Fichtenbaum
BACKGROUND: We previously reported increased unstimulated blood levels of interferon-gamma in persons with latent tuberculosis infection (LTBI) in the United States, suggesting enhanced immune activation in LTBI. To investigate this further in a TB-endemic setting, we assessed interferon-gamma levels in persons with and without LTBI in Peru. METHODS: We analyzed data from patients with and without a recent type 1 (spontaneous) acute myocardial infarction (AMI) who were enrolled from two public hospital networks in Lima, Peru, and underwent LTBI testing using the QuantiFERON® TB Gold In-tube (QFT) assay...
2018: PloS One
Samuel Cohen-Tanugi, Margart L Wright, R Kumar Kadiyala
Infectious tenosynovitis of the hand is a serious condition with a high risk of morbidity. Mycobacterium tuberculosis is a rare cause of tenosynovitis, especially in regions where tuberculosis is no longer endemic, and presents significant diagnostic challenges. We present the case of a 42-year-old woman with no known history of or exposure to tuberculosis and a medical history of systemic lupus erythematosus on chronic immunosuppressive therapy who presented with swelling and erythema in the fifth finger of the left hand of 1-month duration...
April 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Sara M Drayer, Jessica J Shank
Infectious diseases can present similar to ovarian cancer and occur concomitantly with ovarian pathology. With increased worldwide travel and migration of populations, infections endemic to developing countries can emerge in the United States. We present 2 cases of infectious diseases mimicking ovarian carcinomatosis. Two Filipino women presented with abdominal distension and had evaluations suggestive of advanced gynecologic malignancy. The first patient underwent surgery and was found to have peritoneal tuberculosis...
November 2018: Gynecologic Oncology Reports
Mengchuan Luo, Weifei Wang, Qiuming Zeng, Yuebei Luo, Huan Yang, Xiaosu Yang
The present study aimed to summarize the clinical features, alterations in cerebrospinal fluid (CSF), imaging characteristics, diagnostic methods, treatment regimens and outcomes of adult Chinese patients with tuberculous meningitis (TBM). Clinical data of 189 cases with 4 cases confirmed with definite TBM, 65 cases of probable (diagnostic score, ≥12 with imaging or ≥10 without imaging) and 120 cases of possible (diagnostic score, 6-11 with imaging or 6-9 without imaging) TBM admitted to Xiangya Hospital of Central South University between January 2009 and January 2015 were investigated retrospectively...
September 2018: Experimental and Therapeutic Medicine
Pengfei Qiao, Pengfei Zhao, Yang Gao, Yuzhen Bai, Guangming Niu
Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases. Methods: Patients with brucellar spondylitis, spinal tuberculosis or a spinal metastatic tumor (30 cases of each) received conventional MRI and DCE-MRI examination. The volume transfer constant (Ktrans ), rate constant (Kep ), extravascular extracellular volume fraction (Ve ) and plasma volume fraction (Vp ) of the diseased vertebral bodies were measured on the perfusion parameter map, and the differences in these parameters between the patients were compared...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Andrea M Cabibbe, Timothy M Walker, Stefan Niemann, Daniela M Cirillo
Next Generation Sequencing (NGS) technologies using massively parallel processing to interrogate pathogen genomes in days are revolutionising the clinical microbiology practice [1]. Whole genome sequencing (WGS) offers unprecedented resolution for genotyping, outbreak investigation and determination of known sequence variants involved in antimicrobial resistance (AMR), which deep sequencing of selected genomic regions (targeted NGS, tNGS) can further illuminate. WGS-based approach has been proposed for surveillance of bacterial pathogens included in the "priority list" by the World Health Organization (WHO) [2]...
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
David H Wyllie, Esther Robinson, Tim Peto, Derrick W Crook, Adebisi Ajileye, Priti Rathod, Rosemarie Allen, Lisa Jarrett, E Grace Smith, A Sarah Walker
Introduction: Detecting laboratory cross-contamination and mixed tuberculosis infection are important goals of clinical Mycobacteriology laboratories. Objectives: To develop a method detecting mixtures of different M. tuberculosis lineages in laboratories performing Mycobacterial next generation sequencing (NGS). Setting: Public Health England National Mycobacteriology Laboratory Birmingham, which performs Illumina sequencing on DNA extracted from positive Mycobacterial Growth Indicator tubes. Methods: We analysed 4,156 samples yielding M...
September 12, 2018: Journal of Clinical Microbiology
Ricardo A M S Corrêa, Filipe S da Cruz, Cátia C Santos, Thiago C Pimenta, Diego L Franco, Lucas F Ferreira
In this study, the electropolymerization of 4-hydroxyphenylacetic acid (4-HPA) over graphite electrodes (GE) was optimized, aiming its application as a functionalized electrochemical platform for oligonucleotides immobilization. It was investigated for the number of potential cycles and the scan rate influence on the monomer electropolymerization by using cyclic voltammetry technique. It was observed that the polymeric film showed a redox response in the region of +0.53/+0.38 V and the increase in the number of cycles produces more electroactive platforms because of the better electrode coverage...
September 11, 2018: Biosensors
Khundrakpam Herojit Singh, Savita Yadav, Deepak Kumar, Bichitra Kumar Biswal
High-temperature requirement A (HtrA) proteins, which are members of the heat-shock-induced serine protease family, are involved in extracytoplasmic protein quality control and bacterial survival strategies under stress conditions, and are associated with the virulence of several pathogens; they are therefore major drug targets. Mycobacterium tuberculosis possesses three putative HtrAs: HtrA1 (Rv1223), HtrA2 (Rv0983) and HtrA3 (Rv0125). Each has a cytoplasmic region, a transmembrane helix and a periplasmic region...
September 1, 2018: Acta Crystallographica. Section D, Structural Biology
Omar Lazrek, Rida Allah Bassir, El Mehdi Sabri, Moncef Boufettal, Moulay Omar Lamrani, Mohammed Kharmaz, Mustapha Mahfoud, Ahmed Bardouni, Mohamed Salah Berrada
Diaphyseal tuberculosis (TB) is a rare case of the skeletal TB. The following report documents the case of a 52-year-old Moroccan woman with a swelling over the right forearm followed by pulmonary TB under treatment for 3 months. The radiographs of the forearm show a lytic image located at the radius mid-diaphysis. The histopathology confirmed the diagnosis. The patient received surgical drainage with trepanation of the bone. The antibacillary chemotherapy was administered for 6 months. It is, therefore, indispensable to bear in mind the possibility of such atypical presentations of TB when making a rapid and pertinent diagnosis and prescribing the appropriate treatment...
July 2018: International Journal of Mycobacteriology
Siew Yee Thien, Shuwei Zheng
Mycobacterium tuberculosis can cause a myriad of clinical manifestations. We describe a case of a patient with end-stage renal failure, who presented with disseminated tuberculosis over the course of five months, manifesting with a self-resolving mediastinal mass, progressive lymphadenopathy, genitourinary, and musculoskeletal tuberculosis.
July 2018: International Journal of Mycobacteriology
Nishanth Dev, Rahul Kumar
Chyluria is described as passage of chyle in the urine. It results from the formation of lymphaticorenal fistulae due to various etiologies. The most common implicated cause is filariasis especially in endemic areas. Other uncommon causes include thoracic duct trauma or anatomical abnormalities, pregnancy, malignancy, and tuberculosis. Although tuberculosis has been included as a cause, there are only a few case reports suggesting it as an etiology. Tuberculosis can present in various ways. However, chyluria as initial presentation of tuberculosis has never been reported in the literature...
July 2018: International Journal of Mycobacteriology
Hitender Gautam, Sonu Kumari Agrawal, Santosh Kumar Verma, Urvashi B Singh
Background: Tuberculosis is a major global health problem. Tuberculous lymphadenopathy is a most common form of extrapulmonary tuberculosis (EPTB), constitutes 35% of all cases of EPTB. Due to the paucibacillary nature of specimens, smear microscopy and culture offer low sensitivity. Methods: The aim of the present study was to find the clinicodemographic profiles and comparing the performance of Xpert MTB/RIF, conventional polymerase chain reaction (PCR), mycobacteria growth indicator tube (MGIT) 960, histopathological examination, and clinical follow-up of patients in diagnosing of smear-negative tuberculous lymphadenopathy...
July 2018: International Journal of Mycobacteriology
Achraf Machan, Tarik Hanafi, Naoufal Hjira, Mohammed Boui
Tuberculous gummas are an unusual form of tuberculosis (TB) accounting for 1%-2% of all cutaneous TB cases. The aim of this article was to describe the epidemiological, clinical, bacteriological, immunological, and therapeutic features of this form upon a case report and a literature review. Forty-eight case reports were identified through a PubMed and Google Scholar search using the following keywords: "tuberculous gumma" and "metastatic tuberculous abscesse." Tuberculous gumma can occur at any age...
July 2018: International Journal of Mycobacteriology
Samyadipta Dey, Saibal Misra, Mainak Dutta
Primary sinonasal tuberculosis remains a diagnostic challenge as it mimics sinonasal granulomatous disease or neoplasms. Its characteristic signs and symptoms may be non-specific and highly variable. Here we report a unique clinical condition of a 24-year-old man who presented with unilateral nasal obstruction and epiphora for 2 years. He was without any comorbidity, was immunocompetent, and was otherwise healthy. Subsequent investigations, including a computed tomography scan of the paranasal sinuses, and perioperative findings revealed a sinonasal mass involving the lateral nasal wall and paranasal sinuses...
June 2018: Turkish Archives of Otorhinolaryngology
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