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Biomedical ethics

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https://www.readbyqxmd.com/read/28081116/the-sharing-experimental-animal-resources-coordinating-holdings-search-framework-encouraging-reduction-replacement-and-refinement-in-animal-research
#1
Bethny Morrissey, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones, Ingunn Holen, Valerie Speirs
While significant medical breakthroughs have been achieved through using animal models, our experience shows that often there is surplus material remaining that is frequently never revisited but could be put to good use by other scientists. Recognising that most scientists are willing to share this material on a collaborative basis, it makes economic, ethical, and academic sense to explore the option to utilise this precious resource before generating new/additional animal models and associated samples. To bring together those requiring animal tissue and those holding this type of archival material, we have devised a framework called Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) with the aim of making remaining material derived from animal studies in biomedical research more visible and accessible to the scientific community...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28071731/in-silico-experiments-of-zebrafish-behaviour-modeling-swimming-in-three-dimensions
#2
Violet Mwaffo, Sachit Butail, Maurizio Porfiri
Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the exploration of alternative testing methods to reduce the number of subjects, refine experimental designs, and replace live animals. Inspired by the demonstrated advantages of computational studies in other life science domains, we establish an authentic data-driven modelling framework to simulate zebrafish swimming in three dimensions...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065430/informed-consent-in-dental-care-and-research-for-the-older-adult-population-a-systematic-review
#3
REVIEW
Amrita Mukherjee, Alicia A Livinski, Joseph Millum, Steffany Chamut, Shahdokht Boroumand, Timothy J Iafolla, Margo R Adesanya, Bruce A Dye
BACKGROUND: Ethics in health care and research is based on the fundamental principle of informed consent. However, informed consent in geriatric dentistry is not well documented. Poor health, cognitive decline, and the passive nature of many geriatric patients complicate this issue. METHODS: The authors completed this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The authors searched the PubMed (MEDLINE), Web of Science, PsycINFO, and Cochrane Library databases...
January 5, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28063033/reproducibility-issues-avoiding-pitfalls-in-animal-inflammation-models
#4
Jon D Laman, Susanne M Kooistra, Björn E Clausen
In light of an enhanced awareness of ethical questions and ever increasing costs when working with animals in biomedical research, there is a dedicated and sometimes fierce debate concerning the (lack of) reproducibility of animal models and their relevance for human inflammatory diseases. Despite evident advancements in searching for alternatives, that is, replacing, reducing, and refining animal experiments-the three R's of Russel and Burch (1959)-understanding the complex interactions of the cells of the immune system, the nervous system and the affected tissue/organ during inflammation critically relies on in vivo models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28057608/acupuncture-for-children-with-cerebral-palsy-a-systematic-review-protocol
#5
Taipin Guo, Bowen Zhu, Qian Zhang, Yejiao Yang, Qi He, Xinghe Zhang, Xiantao Tai
BACKGROUND: Cerebral palsy (CP), a childhood disease of high morbidity and serious harmfulness, has no effective therapies to completely relieve the associated pain. Acupuncture has been used widely in China to alleviate several CP symptoms, such as pain and motion disorders, despite the deficiency of high-quality evidence related to this practice. OBJECTIVE: The aim of this systematic review protocol is to assess the efficacy and safety of acupuncture for the treatment of children with CP...
January 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28057389/-priority-setting-of-health-interventions-review-of-criteria-approaches-and-role-of-assessment-agencies
#6
Leonor Varela-Lema, Gerardo Atienza-Merino, Marisa López-García
OBJECTIVE: This study was carried out to develop an explicit health priority setting methodology to support decision-making regarding the technologies to be assessed for inclusion in the National Health Service service portfolio. The primary objective is to identify and analyse the criteria, approaches and conceptual frameworks used for national/international priority setting. METHOD: An exhaustive review of the literature was carried out. For this purpose, a search of the main biomedical databases was performed and assessment agency websites were reviewed, among other sources...
January 2, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28029466/-accreditation-of-independent-ethics-committees
#7
Miguel A Ramiro Avilés
OBJECTIVE: According to Law 14/2007 and Royal Decree 1090/2015, biomedical research must be assessed by an Research Ethics Committee (REC), which must be accredited as an Research ethics committee for clinical trials involving medicinal products (RECm) if the opinion is issued for a clinical trial involving medicinal products or clinical research with medical devices. The aim of this study is to ascertain how IEC and IECm accreditation is regulated. METHODS: National and regional legislation governing biomedical research was analysed...
October 29, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28018016/an-ethical-moment-in-data-sharing
#8
Catherine Heeney
This study draws on interviews with forty-nine members of a biomedical research community in the UK that is involved in negotiating data sharing and access. During an interview, an interviewee used the words "ethical moment" to describe a confrontation between collaborators in relation to data sharing. In this article, I use this as a lens for thinking about relations between "the conceptual and the empirical" in a way that allows both analyst and actor to challenge the status quo and consider other ethical possibilities...
January 2017: Science, Technology & Human Values
https://www.readbyqxmd.com/read/28005391/cross-field-comparison-of-ethics-education-golden-rules-and-particulars
#9
Tyler J Mulhearn, Logan L Watts, Brett S Torrence, E Michelle Todd, Megan R Turner, Shane Connelly, Michael D Mumford
Research misconduct negatively impacts the scientific community and society in general. Providing training in the responsible conduct of research (RCR) to researchers is one viable approach to minimizing research misconduct. Although recent evidence suggests ethics training can indeed be effective, little empirical work has examined the similarities and differences across fields. In the present study, we analyzed 62 empirical studies in engineering, biomedical science, social science, and mixed fields. The findings suggest certain instructional principles, or "golden rules," apply generally to all fields...
December 22, 2016: Accountability in Research
https://www.readbyqxmd.com/read/27973722/a-mitochondrial-story-mitochondrial-replacement-identity-and-narrative
#10
Jackie Leach Scully
Mitochondrial replacement techniques (MRT) are intended to avoid the transmission of mitochondrial diseases from mother to child. MRT represent a potentially powerful new biomedical technology with ethical, policy, economic and social implications. Among other ethical questions raised are concerns about the possible effects on the identity of children born from MRT, their families, and the providers or donors of mitochondria. It has been suggested that MRT can influence identity (i) directly, through altering the genetic makeup and physical characteristics of the child, or (ii) indirectly through changing the child's experience of disease, and by generating novel intrafamilial relationships that shape the sense of self...
January 2017: Bioethics
https://www.readbyqxmd.com/read/27968904/aspirin-and-levofloxacin-for-the-prevention-of-the-occurrence-of-prostate-cancer-or-transformation-to-castration-resistant-prostate-cancer-a-two-part-open-label-randomised-controlled-study
#11
Lu Yang, Yongji Chen, Zhuang Tang, Wenbin Xue, Shi Qiu, Ping Tan, Qiang Wei
BACKGROUND: The role that inflammation plays in the development of prostate cancer is unknown. We aimed to assess whether an anti-inflammatory drug or antibiotic, or both, could prevent prostate cancer occurrence and delay transformation to castration-resistant prostate cancer. METHODS: This open-label, randomised, controlled trial recruited participants who had undergone a prostate biopsy in West China Hospital of Sichuan University. Participants older than 40 years pathologically confirmed not to have prostate cancer but who had a prostate with inflammatory cell infiltration were assigned to the prostate cancer prevention (PCP) trial, and those older than 50 years who had pathological results of prostate cancer and were suitable for only androgen-deprivation therapy were assigned to the castration-resistant prostate cancer prevention (C-RPCP) trial...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968850/multimodal-mri-characterisation-of-schizophrenia-a-discriminative-analysis
#12
Han Yang, Hongjian He, Jianhui Zhong
BACKGROUND: Recent studies on MRI-based discrimination of schizophrenia have shown promise. Considering that, in general, pathological changes should display characteristic markers in both brain function and anatomy, machine-learning methods using multimodal MRI features of brain networks might provide a deeper insight into the pathological mechanism of schizophrenia. We aimed to assess the discriminative power of multimodal MRI features and to extract these features of high discriminative information for classification of patients with schizophrenia...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968834/methylation-loci-associated-with-body-mass-index-waist-circumference-and-waist-to-hip-ratio-in-chinese-adults-an-epigenome-wide-analysis
#13
Biqi Wang, Wenjing Gao, Jun Li, Canqing Yu, Weihua Cao, Jun Lv, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Liming Liang, Tangchun Wu, Liming Li
BACKGROUND: DNA methylation has been implicated in the pathology of obesity, but little is known about such epigenetic variants in Chinese people. We conducted an epigenome-wide analysis of methylation at CpG sites in relation to body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) among Chinese adult populations. METHODS: 469 twins from the Chinese National Twin Registry were the discovery cohort. After quality control, methylation levels in whole blood leukocyte DNA were tested for association with BMI, WC, and WHR using mixed linear regressions, adjusting for demographics, lifestyle, and family structure...
October 2016: Lancet
https://www.readbyqxmd.com/read/27965220/the-use-of-rats-and-mice-as-animal-models-in-ex-vivo-bone-growth-and-development-studies
#14
A A Abubakar, M M Noordin, T I Azmi, U Kaka, M Y Loqman
In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led to the evolution of an ex vivo model system which partially or completely surmounted some of the constraints faced in an in vivo model system. The ex vivo rodent bone culture system has been used to elucidate the understanding of skeletal physiology and pathophysiology for more than 90 years...
December 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27931155/prenatal-paradox-an-integrative-review-of-women-s-experiences-with-prenatal-screening-for-fetal-aneuploidy-and-neural-tube-defects
#15
Tamra L Shea
BACKGROUND: As prenatal screening for fetal aneuploidy and neural tube defects evolves technologically and becomes increasingly utilized worldwide, an evaluation of the available evidence on women's experiences with prenatal screening is warranted. AIMS: To conduct an integrative review to enhance understanding of women's experiences with prenatal screening for fetal aneuploidy and neural tube defects. DESIGN: Systematic literature searches from January 2005 through January 2016, using the CINAHL, PubMed, and PsychInfo electronic databases and ancestry searches of included studies were performed to identify previously published, peer-reviewed quantitative and qualitative studies...
December 30, 2016: Contemporary Nurse
https://www.readbyqxmd.com/read/27910800/routine-x-ray-of-the-chest-is-not-justified-in-staging-of-cutaneous-melanoma-patients
#16
Caroline Asirvatham Gjørup, Helle Westergren Hendel, Rita Kaae Pilegaard, Cecilie Balslev Willert, Lisbet Rosenkrantz Hölmich
INTRODUCTION: The incidence of cutaneous melanoma is increasing in Denmark and worldwide. However, the prevalence of distant metastases at the time of diagnosis has decreased to 1%. We therefore questioned the value of routine preoperative chest X-ray (CXR) for staging asymptomatic melanoma patients and hypothesised that routine CXR is not justified. METHODS: A retrospective study was conducted on patients undergoing wide local excision and sentinel lymph node biopsy for cutaneous melanoma in the period from 2010 to 2014...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27903939/nature-and-governance-of-veterinary-clinical-research-conducted-in-the-uk
#17
P Fordyce, S Mullan
In order to quantify the amount of clinical research conducted on client-owned animals under the Veterinary Surgeons Act 1966, and the nature and extent of any ethical review of that research, a questionnaire was sent to 6 UK veterinary schools, 1 charity veterinary clinic and 12 private referral clinics. The questionnaire examined whether and how much clinical research respondents undertook, and the composition of any ethical review panels examining research proposals. The questionnaire revealed a substantial amount of clinical research was conducted in the UK, with over 200 veterinary surgeons involved in the year of the survey, with at least 170 academic papers involving clinical research published by respondents in the same year...
November 30, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27903824/societal-impact-of-synthetic-biology-responsible-research-and-innovation-rri
#18
REVIEW
Daniel Gregorowius, Anna Deplazes-Zemp
Synthetic biology is an emerging field at the interface between biology and engineering, which has generated many expectations for beneficial biomedical and biotechnological applications. At the same time, however, it has also raised concerns about risks or the aim of producing new forms of living organisms. Researchers from different disciplines as well as policymakers and the general public have expressed the need for a form of technology assessment that not only deals with technical aspects, but also includes societal and ethical issues...
November 30, 2016: Essays in Biochemistry
https://www.readbyqxmd.com/read/27899114/developing-translational-medicine-professionals-the-marie-sk%C3%A5-odowska-curie-action-model
#19
Alessandra Petrelli, Berent J Prakken, Norman D Rosenblum
End goal of translational medicine is to combine disciplines and expertise to eventually promote improvement of the global healthcare system by delivering effective therapies to individuals and society. Well-trained experts of the translational medicine process endowed with profound knowledge of biomedical technology, ethical and clinical issues, as well as leadership and teamwork abilities are essential for the effective development of tangible therapeutic products for patients. In this article we focus on education and, in particular, we discuss how programs providing training on the broad spectrum of the translational medicine continuum have still a limited degree of diffusion and do not provide professional support and mentorship in the long-term, resulting in the lack of well established professionals of translational medicine (TMPs) in the scientific community...
November 29, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27858217/alternative-animal-and-non-animal-models-for-drug-discovery-and-development-bonus-or-burden
#20
Irlan Almeida Freires, Janaina de Cássia Orlandi Sardi, Ricardo Dias de Castro, Pedro Luiz Rosalen
Mammalian models have served as a basis for R&D over the past decades. Nevertheless, these models are expensive, laborious, may yield results that cannot always be translated into the human in vivo situation and, more recently, have reverberated great social and ethical dilemmas. Hence, the prospect of changes in the global scientific scenario and the Three Rs principle (Reduction, Replacement and Refinement) have encouraged the development of alternative methods to the use of mammals. Despite the efforts, suitable alternative tests are not available in all areas of biomedical research, as regulatory acceptance requires time, prior validation and robust financial and scientific investment...
November 17, 2016: Pharmaceutical Research
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