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Biomedical ethics

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https://www.readbyqxmd.com/read/27910800/routine-x-ray-of-the-chest-is-not-justified-in-staging-of-cutaneous-melanoma-patients
#1
Caroline Asirvatham Gjørup, Helle Westergren Hendel, Rita Kaae Pilegaard, Cecilie Balslev Willert, Lisbet Rosenkrantz Hölmich
INTRODUCTION: The incidence of cutaneous melanoma is increasing in Denmark and worldwide. However, the prevalence of distant metastases at the time of diagnosis has decreased to 1%. We therefore questioned the value of routine preoperative chest X-ray (CXR) for staging asymptomatic melanoma patients and hypothesised that routine CXR is not justified. METHODS: A retrospective study was conducted on patients undergoing wide local excision and sentinel lymph node biopsy for cutaneous melanoma in the period from 2010 to 2014...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27903939/nature-and-governance-of-veterinary-clinical-research-conducted-in-the-uk
#2
P Fordyce, S Mullan
In order to quantify the amount of clinical research conducted on client-owned animals under the Veterinary Surgeons Act 1966, and the nature and extent of any ethical review of that research, a questionnaire was sent to 6 UK veterinary schools, 1 charity veterinary clinic and 12 private referral clinics. The questionnaire examined whether and how much clinical research respondents undertook, and the composition of any ethical review panels examining research proposals. The questionnaire revealed a substantial amount of clinical research was conducted in the UK, with over 200 veterinary surgeons involved in the year of the survey, with at least 170 academic papers involving clinical research published by respondents in the same year...
November 30, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27903824/societal-impact-of-synthetic-biology-responsible-research-and-innovation-rri
#3
REVIEW
Daniel Gregorowius, Anna Deplazes-Zemp
Synthetic biology is an emerging field at the interface between biology and engineering, which has generated many expectations for beneficial biomedical and biotechnological applications. At the same time, however, it has also raised concerns about risks or the aim of producing new forms of living organisms. Researchers from different disciplines as well as policymakers and the general public have expressed the need for a form of technology assessment that not only deals with technical aspects, but also includes societal and ethical issues...
November 30, 2016: Essays in Biochemistry
https://www.readbyqxmd.com/read/27899114/developing-translational-medicine-professionals-the-marie-sk%C3%A5-odowska-curie-action-model
#4
Alessandra Petrelli, Berent J Prakken, Norman D Rosenblum
End goal of translational medicine is to combine disciplines and expertise to eventually promote improvement of the global healthcare system by delivering effective therapies to individuals and society. Well-trained experts of the translational medicine process endowed with profound knowledge of biomedical technology, ethical and clinical issues, as well as leadership and teamwork abilities are essential for the effective development of tangible therapeutic products for patients. In this article we focus on education and, in particular, we discuss how programs providing training on the broad spectrum of the translational medicine continuum have still a limited degree of diffusion and do not provide professional support and mentorship in the long-term, resulting in the lack of well established professionals of translational medicine (TMPs) in the scientific community...
November 29, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27858217/alternative-animal-and-non-animal-models-for-drug-discovery-and-development-bonus-or-burden
#5
Irlan Almeida Freires, Janaina de Cássia Orlandi Sardi, Ricardo Dias de Castro, Pedro Luiz Rosalen
Mammalian models have served as a basis for R&D over the past decades. Nevertheless, these models are expensive, laborious, may yield results that cannot always be translated into the human in vivo situation and, more recently, have reverberated great social and ethical dilemmas. Hence, the prospect of changes in the global scientific scenario and the Three Rs principle (Reduction, Replacement and Refinement) have encouraged the development of alternative methods to the use of mammals. Despite the efforts, suitable alternative tests are not available in all areas of biomedical research, as regulatory acceptance requires time, prior validation and robust financial and scientific investment...
November 17, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27842861/-information-and-consent-forms-for-hematopoietic-stem-cell-transplantation-donors-and-recipients-guidelines-from-the-franchophone-society-of-bone-marrow-transplantation-and-cellular-therapy-sfgm-tc
#6
Bénédicte Bruno, Jean-Baptiste Thibert, Nelly Bancillon, Anna Desbos, Abir Fawaz, Isabelle Fournier, Carole Genty, Dominique Issarni, Sandrine Leveille, Christelle Premel, Alice Polomeni, Myriam Renault, Sylvie Tarillon, Anne Wallart, Ibrahim Yakoub-Agha, Dominique Bordessoule
Within the context of the SFGM-TC's 6th workshop series on the harmonization of clinical practices, our workshop proposes a standardization of the informed consent process for hematopoietic stem cell donors and recipients leading up to an autologous or allogenic transplantation. All informed consent was for bone marrow or peripheral stem cell donors, and mononuclear/lymphocyte donors according to usual procedures. The informed consent for autologous and allogenic related or unrelated adults and pediatric transplantation patients have been included...
November 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27834205/rigorous-science-a-how-to-guide
#7
EDITORIAL
Arturo Casadevall, Ferric C Fang
Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word "rigor" is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental design, sound statistical analysis, recognition of error, avoidance of logical fallacies, and intellectual honesty...
November 8, 2016: MBio
https://www.readbyqxmd.com/read/27829573/advancing-interprofessional-primary-health-care-services-in-rural-settings-for-people-with-chronic-low-back-disorders-protocol-of-a-community-based-randomized-controlled-trial
#8
Brenna Bath, Stacey Lovo Grona, Stephan Milosavljevic, Nazmi Sari, Biaka Imeah, Megan E O'Connell
BACKGROUND: Chronic low back disorders (CLBDs) are a substantial burden on individuals and societies, and impact up to 20% of Canadians. Rural and remote residents are approximately 30% more likely to have CLBDs. Reduced access to appropriate team-based health services, including physical therapy, is a key factor that may magnify the impact of CLBD on pain, physical function, overall quality of life, health-related system costs, and individual costs. OBJECTIVE: The purpose of this project is to evaluate the validity, comparative effectiveness, costs, barriers, and facilitators of an interprofessional management approach for people with CLBDs, delivered via telehealth...
November 9, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27809197/ethics-in-humanitarian-services-report-on-the-earthquake-in-nepal
#9
Ramesh P Aacharya, Sanjeeb Tiwari, Tirtha M Shrestha
The Nepal earthquake was one of the biggest natural calamities of the year 2015. This paper attempts to explore the ethical issues involved in the humanitarian services rendered during the crisis and thereafter. The four principles of biomedical ethics - autonomy, beneficence, non-maleficence, and justice - are discussed in relation to the relief activities immediately following the disaster and the subsequent long-term activities, such as rehabilitation, wherever applicable. The discussion touches upon public health components such as vulnerable populations, environmental ethics and justice for the future...
October 19, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27807750/biobanks-and-their-clinical-application-and-informatics-challenges
#10
Lan Yang, Yalan Chen, Chunjiang Yu, Bairong Shen
Biobanks are one of the most important biomedical research resources and contribute to the development of biomarker detection, molecular diagnosis, translational medicine, and multidisciplinary disease research, as well as studies of interactions between genetic and environmental or lifestyle factors. Aiming for the wide clinical application of biobanks, biobanking efforts have recently switched from a focus on accumulating samples to both formalizing and sustaining collections in light of the rapid progress in the fields of personalized medicine and bioinformatics analysis...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27806529/ethics-of-biological-sampling-research-with-aboriginal-communities-in-canada
#11
Behdin Nowrouzi, Lorrilee McGregor, Alicia McDougall, Donna Debassige, Jennifer Casole, Christine Nguyen, Behnam Nowrouzi-Kia, Deborah McGregor
BACKGROUND: The objective of this paper is to identify key ethical issues associated with biological sampling in Aboriginal populations in Canada and to recommend approaches that can be taken to address these issues. METHODS: Our work included the review of notable biological sampling cases and issues. We examined several significant cases (Nuu-chah-nult people of British Columbia, Hagahai peoples of Papua New Guinea and the Havasupai tribe of Arizona) on the inappropriate use of biological samples and secondary research in Aboriginal populations by researchers...
August 4, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27798041/economic-evaluation-of-a-shortened-standardised-treatment-regimen-of-antituberculosis-drugs-for-patients-with-multidrug-resistant-tuberculosis-stream-study-protocol
#12
Elvis Gama, Jason Madan, Ivor Langley, Mamo Girma, Denise Evans, Sydney Rosen, S Bertel Squire
INTRODUCTION: Multidrug-resistant tuberculosis (MDR-TB) poses a serious financial challenge to health systems and patients. The current treatment for patients with MDR-TB takes up to 24 months to complete. Evidence for a shorter regimen which differs from the standard WHO recommended MDR-TB regimen and typically lasts between 9 and 12 months has been reported from Bangladesh. This evaluation aims to assess the economic impact of a shortened regimen on patients and health systems. This evaluation is innovative as it combines patient and health system costs, as well as operational modelling in assessing the impact...
October 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27783799/-disability-inability-and-vulnerability-on-ableism-or-the-pre-eminence-of-ableist-and-biomedical-approaches-of-the-human-subjects-ethics-committee-of-ufsc
#13
Anahi Guedes de Mello
Anthropology has increasingly questioned the hegemony of biomedical knowledge in ethical review processes of social research projects prevailing in Brazil, which was governed until 2012 by the Human Research Ethics Committee of each institution under the auspices of the National Research Ethics Commission (CONEP). This was mandated through Resolution No. 196/1996 prevailing in 2012 when this field research was conducted. The scope of this study is to recount and reflect upon the barriers to obtaining approval in 2012 for my master's research project from the Human Research Ethics Committee of the Federal University of Santa Catarina (CEP/UFSC) in Florianopolis...
October 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27779722/program-f%C3%A3-r-eu-utbildade-l%C3%A3-kare-%C3%A3-verbryggar-kulturella-skillnader
#14
Inger Hagqvist, Stig Rödjer, Anna Aggeryd, Ebba Holmberg, Göran Bondjers
Experiences from PLUS - program for learning and development in Swedish health care In Sweden, more than half of newly registered physicians have been trained outside of the country. Thus, they are not familiar with Swedish culture and the Swedish healthcare system. To support their introduction to a professional carrier in Sweden, in line with the WHO ethical code for recruitment of health personnel, the health care region of Western Sweden established PLUS - program for learning and development in Swedish Health care...
October 24, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27776540/the-alliance-between-genetic-biobanks-and-patient-organisations-the-experience-of-the-telethon-network-of-genetic-biobanks
#15
Chiara Baldo, Lorena Casareto, Alessandra Renieri, Giuseppe Merla, Barbara Garavaglia, Stefano Goldwurm, Elena Pegoraro, Maurizio Moggio, Marina Mora, Luisa Politano, Luca Sangiorgi, Raffaella Mazzotti, Valeria Viotti, Ilaria Meloni, Maria Teresa Pellico, Chiara Barzaghi, Chiuhui Mary Wang, Lucia Monaco, Mirella Filocamo
BACKGROUND: Rare diseases (RDs) are often neglected because they affect a small percentage of the population (6-8 %), which makes research and development of new therapies challenging processes. Easy access to high-quality samples and associated clinical data is therefore a key prerequisite for biomedical research. In this context, Genetic Biobanks are critical to developing basic, translational and clinical research on RDs. The Telethon Network of Genetic Biobanks (TNGB) is aware of the importance of biobanking as a service for patients and has started a dialogue with RD-Patient Organisations via promotion of dedicated meetings and round-tables, as well as by including their representatives on the TNGB Advisory Board...
October 24, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27774216/just-compensation-a-no-fault-proposal-for-research-related-injuries
#16
Leslie Meltzer Henry, Megan E Larkin, Elizabeth R Pike
Biomedical research, no matter how well designed and ethically conducted, carries uncertainties and exposes participants to risk of injury. Research injuries can range from the relatively minor to those that result in hospitalization, permanent disability, or even death. Participants might also suffer a range of economic harms related to their injuries. Unlike the vast majority of developed countries, which have implemented no-fault compensation systems, the United States continues to rely on the tort system to compensate injured research participants-an approach that is no longer morally defensible...
November 2015: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27763403/ethical-challenges-in-the-care-of-the-inpatient-with-morbid-obesity
#17
Paul L Schneider, Zhaoping Li
OBJECTIVE: To provide a thorough analysis of the range of ethical concerns that may present in relation to the care of the morbidly obese inpatient over the course of several years of care. METHODS: A narrative of the patient's complex medical care is given, with particular attention to the recommendations of three separate ethics committee consultations that were sought by his health care providers. An ethical analysis of the relevant issues is given within the Principles of Biomedical Ethics framework, highlighting the principles of autonomy, beneficence, non-maleficence, and justice...
2016: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/27757803/low-and-high-dose-radioiodine-therapy-for-low-intermediate-risk-differentiated-thyroid-cancer-a-preliminary-clinical-trial
#18
Yuan Qu, Rui Huang, Lin Li
OBJECTIVES: To compare the ablation results, therapeutic responses and adverse reactions between a low dose (1.1 GBq) or high dose (3.7 GBq) of (131)I in low-/intermediate-risk differentiated thyroid cancer (DTC) patients. The factors influencing the ablation result and therapeutic response were also analyzed. METHODS: The researchers used a random number table to randomly assign the enrolled patients to the low-dose group or high-dose group at a 1:1 ratio, and assessment of ablation result, therapeutic response, and adverse reactions evaluated 6 ± 3 months after therapy...
October 18, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27742624/focused-ultrasound-examination-of-the-chest-on-patients-admitted-with-acute-signs-of-respiratory-problems-a-study-protocol-for-a-pragmatic-randomised-controlled-multicentre-trial
#19
M Riishede, C B Laursen, L S Teglbjærg, A T Lassen, G Baatrup
INTRODUCTION: Patients with acute respiratory problems poses a diagnostic challenge because similar symptoms can be caused by various pathological conditions. Focused ultrasound examination (f-US) of the heart and lungs has proven to increase the diagnostic accuracy in these patients. In this protocol of a randomised multicentre trial, we study the effect of f-US of the heart and lungs in patients with respiratory problems performed by emergency physicians (EP) as soon as the patient arrives to the emergency department (ED)...
October 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/27733160/personalized-assent-for-pediatric-biobanks
#20
Noor A A Giesbertz, Karen Melham, Jane Kaye, Johannes J M van Delden, Annelien L Bredenoord
Pediatric biobanking is considered important for generating biomedical knowledge and improving (pediatric) health care. However, the inclusion of children's samples in biobanks involves specific ethical issues. One of the main concerns is how to appropriately engage children in the consent procedure. We suggest that children should be involved through a personalized assent procedure, which means that both the content and the process of assent are adjusted to the individual child. In this paper we provide guidance on how to put personalized assent into pediatric biobanking practice and consider both the content and process of personalized assent...
October 12, 2016: BMC Medical Ethics
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