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Biomedical ethics

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https://www.readbyqxmd.com/read/28936750/person-centered-care-and-personalized-medicine-irreconcilable-opposites-or-potential-companions
#1
Leila El-Alti, Lars Sandman, Christian Munthe
In contrast to standardized guidelines, personalized medicine and person centered care are two notions that have recently developed and are aspiring for more individualized health care for each single patient. While having a similar drive toward individualized care, their sources are markedly different. While personalized medicine stems from a biomedical framework, person centered care originates from a caring perspective, and a wish for a more holistic view of patients. It is unclear to what extent these two concepts can be combined or if they conflict at fundamental or pragmatic levels...
September 21, 2017: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/28931749/ethics-in-published-brain-computer-interface-research
#2
Laura Specker Sullivan, Judy Illes
OBJECTIVE: Sophisticated signal processing has opened the doors to more research with human subjects than ever before. The increase in the use of human subjects in research comes with a need for increased human subjects protections. APPROACH: We quantified the presence or absence of ethics language in published reports of BCI studies that involved human subjects and qualitatively characterized ethics statements. MAIN RESULTS: Reports of BCI studies with human subjects that are published in neural engineering and engineering journals are anchored in the rationale of technological improvement...
September 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28928344/knowledge-of-scientific-misconduct-in-publication-among-medical-students
#3
Syed Muhammad Mubeen, Rabia Ghayas, Syed Hasan Adil Rizvi, Sohaib Ahmed Khan
BACKGROUND: Publication is a central element in research dissemination and scientific misconduct in publication is relatively ignored in biomedical research. This study is to assess the knowledge of scientific misconduct in publication among private and public sector medical students. METHODS: A questionnaire-based cross-sectional study was carried in four (two public and two private) medical colleges of Karachi in 2015. After ethical approval, data were collected through convenient sampling and analyzed in SPSS 16...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28928056/-vaccine-hesitancy-discourse-analysis-of-parents-who-have-not-fully-or-partially-vaccinated-their-children
#4
Maite Cruz Piqueras, Ainhoa Rodríguez García de Cortazar, Joaquín Hortal Carmona, Javier Padilla Bernáldez
OBJECTIVE: To analyse and understand vaccination hesitancy discourses, particularly those of people who have decided not to vaccinate their sons and daughters. METHODS: Qualitative study of five individual interviews and two focus groups with people who chose not to vaccinate their children in the province of Granada (Spain). RESULTS: Mothers and fathers manifest a system of health beliefs different to the biomedical paradigm. From an ethical point of view, they justify their position based on the right to autonomy and responsibility for their decisions...
September 16, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28927532/beyond-mouse-cancer-models-three-dimensional-human-relevant-in-vitro-and-non-mammalian-in-vivo-models-for-photodynamic-therapy
#5
REVIEW
Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska
The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system are essential for a successful research project. Currently, various sophisticated in vitro and in vivo models are being designed and developed in order to replace the use of mammalian models to investigate the mechanisms of action, activity and properties of novel compounds or treatment modalities...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#6
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28905258/is-biomedical-research-protected-from-predatory-reviewers
#7
Aceil Al-Khatib, Jaime A Teixeira da Silva
Authors endure considerable hardship carrying out biomedical research, from generating ideas to completing their manuscripts and submitting their findings and data (as is increasingly required) to a journal. When researchers submit to journals, they entrust their findings and ideas to editors and peer reviewers who are expected to respect the confidentiality of peer review. Inherent trust in peer review is built on the ethical conduct of authors, editors and reviewers, and on the respect of this confidentiality...
September 13, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28901597/the-limits-of-the-treatment-enhancement-distinction-as-a-guide-to-public-policy
#8
Alexandre Erler
Many believe that the treatment-enhancement distinction (TED) marks an important ethical boundary that we should use to shape public policy on biomedical interventions. A common justification for this purported normative force appeals to the idea that, whereas treatments respond to genuine medical needs, (most) enhancements can only satisfy mere preferences or "expensive tastes". This article offers a critique of that justification, while still accepting the TED as a conceptual tool, as well as some of the key ethical axioms endorsed by its proponents...
October 2017: Bioethics
https://www.readbyqxmd.com/read/28888838/space-for-human-connection-in-antenatal-education-uncovering-women-s-hopes-using-participatory-action-research
#9
Vivienne Brady, Joan Lalor
OBJECTIVE: the aim of this research was to initiate active consultation with women and antenatal educators in the development and delivery of antenatal education that was mutually relevant. DESIGN: a Participatory Action Research approach influenced by feminist concerns was used to guide the research. Data were analysed by the researcher and participants using a Voice Centred Relational Method of Analysis. SETTING: an Antenatal Education service in a consultant-led tertiary referral unit in Ireland...
August 30, 2017: Midwifery
https://www.readbyqxmd.com/read/28876621/the-absolute-number-of-repeat-operations-for-complex-intra-abdominal-sepsis-is-not-a-useful-predictor-of-non-survival
#10
M F Scriba, G L Laing, J L Bruce, D L Clarke
BACKGROUND: When multiple repeat laparotomies are required to manage intra-abdominal sepsis, questions about futility of treatment frequently arise. This study focuses specifically on patients who required two or more repeat laparotomies and describes the spectrum of disease necessitating multiple repeat laparotomies and the associated outcomes in the hope of clarifying the issue. METHOD: This study was conducted over a 20-month period (December 2012 - July 2014) at Greys Hospital in Pietermaritzburg, South Africa...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876358/animal-models-in-biological-and-biomedical-research-experimental-and-ethical-concerns
#11
Monica L Andersen, Lucile M F Winter
Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. In this review, we intend to give examples on how animals are used in the health research related to some major health problems in Brazil, as well as to stimulate discussion about the application of ethics in the use of animals in research and education, highlighting the role of National Council for the Control of Animal Experimentation (Conselho Nacional de Controle de Experimentação Animal - CONCEA) in these areas...
September 4, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28861725/proposal-for-the-creation-of-a-national-strategy-for-precision-medicine-in-cancer-a-position-statement-of-seom-seap-and-sefh
#12
P Garrido, A Aldaz, R Vera, M A Calleja, E de Álava, M Martín, X Matías-Guiu, J Palacios
Precision medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Precision medicine is transforming clinical and biomedical research, as well as health care itself from a conceptual, as well as a methodological viewpoint, providing extraordinary opportunities to improve public health and lower the costs of the healthcare system. However, the implementation of precision medicine poses ethical-legal, regulatory, organizational, and knowledge-related challenges...
August 31, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28859347/a-hospital-based-committee-of-moral-philosophy-to-revive-ethics
#13
Margaux Illy, Pierre Le Coz, Jean-Louis Mege
The Méditerranée Infection Foundation's primary goal is supporting a research hospital for the treatment of infectious diseases in Marseille. The main objective of this innovative center is to understand the mechanisms of contagion and face them. The Foundation will include a committee on moral philosophy that will accompany and supervise biomedical research. This is not a conventional ethics committee, frequently giving rise to a board's bureaucratic excesses, which might slow down creative biomedical clinical research without necessarily restricting abuses...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28853172/when-doctors-deny-drugs-sexism-and-contraception-access-in-the-medical-field
#14
J B Delston
Politicians, employers, courts, and health insurance companies are often discussed as problematically preventing access to birth control. However, doctors have more direct control over women's health and quietly have been much more effective at preventing patients' access to contraception. Obstetrician/Gynecologists routinely deny their patients access to contraception ostensibly in the name of health by withholding birth control until patients undergo yearly pap smears. I argue that those in the medical field are motivated by similarly sexist concerns as those in other major institutions in the United States, but that they are often overlooked in discussions of biomedical ethics...
August 29, 2017: Bioethics
https://www.readbyqxmd.com/read/28835156/patient-s-dignity-in-intensive-care-unit-a-critical-ethnography
#15
Farimah Shirani Bidabadi, Ahmadreza Yazdannik, Ali Zargham-Boroujeni
BACKGROUND: Maintaining patient's dignity in intensive care units is difficult because of the unique conditions of both critically-ill patients and intensive care units. OBJECTIVES: The aim of this study was to uncover the cultural factors that impeded maintaining patients' dignity in the cardiac surgery intensive care unit. RESEARCH DESIGN: The study was conducted using a critical ethnographic method proposed by Carspecken. Participants and research context: Participants included all physicians, nurses and staffs working in the study setting (two cardiac surgery intensive care units)...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28829266/a-bridge-back-to-the-future-public-health-ethics-bioethics-and-environmental-ethics
#16
Lisa M Lee
Contemporary biomedical ethics and environmental ethics share a common ancestry in Aldo Leopold's and Van Rensselaer Potter's initial broad visions of a connected biosphere. Over the past five decades, the two fields have become strangers. Public health ethics, a new subfield of bioethics, emerged from the belly of contemporary biomedical ethics and has evolved over the past 25 years. It has moved from its traditional concern with the tension between individual autonomy and community health to a wider focus on social justice and solidarity...
September 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28812979/truth-in-research-labelling
#17
John H Noble
This report describes the background and context of a currently circulating petition to the US Congress that seeks amendment of Section 801 of the Public Health Services Act (42 U.S.C. 282) to close a loophole in existing law which makes possible post hoc adjustment of randomised controlled trial (RCT) results reported to the Food and Drug Administration that differ from those reported to ClinicalTrials.gov and to medical journals. The report describes the petition's rationale, underlying assumptions, and support for its proposed remedy in deontological, consequentialist, and casuist philosophical ethics theories...
July 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28811838/ethical-religion-in-primary-care
#18
Malcolm Torry
Religion is increasingly significant in UK society, and is highly significant for many patients and primary care practitioners. An important task for the practitioner is to ensure that the place of religion in the patient/practitioner relationship is treated with the same ethical seriousness as every other aspect of that relationship. The article finds the 'four principles of biomedical ethics' to be applicable, and recent GMC guidelines to be consistent with the four principles. The article applies the four principles to the particular case of practitioners wearing religious symbolism...
July 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/28806989/maximising-value-from-a-united-kingdom-biomedical-research-centre-study-protocol
#19
Trisha Greenhalgh, Pavel V Ovseiko, Nick Fahy, Sara Shaw, Polly Kerr, Alexander D Rushforth, Keith M Channon, Vasiliki Kiparoglou
BACKGROUND: Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research...
August 14, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28803222/biobanking-in-the-subcontinent-exploring-concerns
#20
Aamir M Jafarey, Sualeha Siddiq Shekhani, Bushra Shirazi
Biobanking is an important tool for biomedical research. However, it raises a variety of ethical issues, which are compounded in the developing world. This paper is based on data from three sources on the ethical issues associated with biobanking, including a mixed method pilot study conducted with students in Karachi, Pakistan, a workshop in Karachi, and another workshop held in Bengaluru, India. Findings from these sources reveal a unanimous lack of clarity about what constitutes a biobank. While informed consent was deemed necessary for storage of materials, participants were unsure of how this could be achieved for samples stored indefinitely for future research...
July 11, 2017: Indian Journal of Medical Ethics
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