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https://www.readbyqxmd.com/read/29771040/-the-value-of-plasma-ebv-dna-testing-in-high-risk-group-of-nasopharyngeal-carcinoma-in-the-nasal-endoscopy
#1
X F He, X Yu, M F Ji, M Y Fu
Objective: The aim of this study is to evaluate the level of plasma EBV DNA and nasal endoscopy in high risk population of nasopharyngeal carcinoma, and to explore the value of EBV DNA testing in nasal endoscopy. Method: The nasopharyngeal carcinoma was screened in High-incidence Area of Zhongshan City. EBV antibody was detected by ELISA, and 427 patients with high risk of nasopharyngeal carcinoma were identified. In the high risk population the plasma EBV-DNA was measured using Fluorescent quantitative PCR, and all patients were used nasal endoscopy in the first two years...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29764493/nasopharyngeal-brushing-a-convenient-and-feasible-sampling-method-for-nucleic-acid-based-nasopharyngeal-carcinoma-research
#2
Pei-Fen Zhang, Xiao-Hui Zheng, Xi-Zhao Li, Tian Tian, Shao-Dan Zhang, Ye-Zhu Hu, Wei-Hua Jia
BACKGROUND: Tissue specimens for nasopharyngeal carcinoma (NPC) research are scarce because of sampling difficulties. Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC diagnosis. The present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for research. METHODS: Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC patients...
April 12, 2018: Cancer communications
https://www.readbyqxmd.com/read/29760067/sequencing-based-counting-and-size-profiling-of-plasma-epstein-barr-virus-dna-enhance-population-screening-of-nasopharyngeal-carcinoma
#3
W K Jacky Lam, Peiyong Jiang, K C Allen Chan, Suk H Cheng, Haiqiang Zhang, Wenlei Peng, O Y Olivia Tse, Yu K Tong, Wanxia Gai, Benny C Y Zee, Brigette B Y Ma, Edwin P Hui, Anthony T C Chan, John K S Woo, Rossa W K Chiu, Y M Dennis Lo
Circulating tumor-derived DNA testing for cancer screening has recently been demonstrated in a prospective study on identification of nasopharyngeal carcinoma (NPC) among 20,174 asymptomatic individuals. Plasma EBV DNA, a marker for NPC, was detected using real-time PCR. While plasma EBV DNA was persistently detectable in 97.1% of the NPCs identified, ∼5% of the general population had transiently detectable plasma EBV DNA. We hypothesized that EBV DNA in plasma of subjects with or without NPC may have different molecular characteristics...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29743400/-epstein-barr-virus-associated-hemophagocytic-lymphohistiocytosis-subsequent-to-rabbit-antithymocyte-globulin-administration-and-successfully-treated-with-rituximab-in-a-patient-with-aplastic-anemia
#4
Hiroaki Nagata, Takahiro Fujino, Ayako Muramatsu, Yuka Kawaji, Kodai Kuriyama, Muneo Oshiro, Yoshiko Hirakawa, Toshiki Iwai, Hitoji Uchiyama
Rabbit antithymocyte globulin (ATG) is an effective immunosuppressive therapy for patients with aplastic anemia (AA). However, Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD) is a rare but serious complication of the therapy. An 81-year-old man was diagnosed with severe AA on the occasion of melena. Because cyclosporine monotherapy did not improve his condition, rabbit ATG was additionally administered. Thirty-one days after the administration of rabbit ATG, the patient presented with fever and general malaise...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29743394/-cerebrospinal-fluid-findings-in-chronic-active-epstein-barr-virus-infection-with-central-nervous-system-involvement
#5
Mayumi Yoshimori, Ken-Ichi Imadome, Shohei Tomii, Kouhei Yamamoto, Osamu Miura, Ayako Arai
As chronic active Epstein-Barr virus (EBV) infection (CAEBV) progresses, EBV-infected tumor cells invade the central nervous system (CNS). To establish a diagnostic procedure for CNS invasion, we retrospectively analyzed cerebrospinal fluid (CSF) obtained from eight patients. Two patients presented with consciousness disturbance and were diagnosed with CNS invasion based on scan and autopsy results, respectively. The remaining six patients were diagnosed without CNS invasion by clinical findings and scans. In the two patients with CNS invasion, the number of mononuclear cells and the protein concentration were increased, whereas the CSF to serum glucose ratio and the adenosine deaminase concentration were raised...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29743367/a-screen-for-epstein-barr-virus-proteins-that-inhibit-the-dna-damage-response-reveals-a-novel-histone-binding-protein
#6
Ting-Hin Ho, Justine Sitz, Qingtang Shen, Ariane Leblanc-Lacroix, Eric I Campos, Ivan Borozan, Edyta Marcon, Jack Greenblatt, Amelie Fradet-Turcotte, Dong-Yan Jin, Lori Frappier
To replicate and persist in human cells, linear double-stranded (ds) DNA viruses, such as Epstein-Barr virus (EBV), must overcome the host DNA damage response (DDR) that is triggered by the viral genomes. Since this response is necessary to maintain cellular genome integrity, its inhibition by EBV is likely an important factor in the development of cancers associated with EBV infection, including gastric carcinoma. Here we present the first extensive screen of EBV proteins that inhibit dsDNA break signaling...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29732319/epstein-barr-virus-in-gliomas-cause-association-or-artifact
#7
REVIEW
Saghir Akhtar, Semir Vranic, Farhan Sachal Cyprian, Ala-Eddin Al Moustafa
Gliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent advances in chemotherapy. The etiology of gliomas is unknown, but neurotropic viruses including the Epstein-Barr virus (EBV) that is transmitted via salivary and genital fluids have been implicated recently. EBV is a member of the gamma herpes simplex family of DNA viruses that is known to cause infectious mononucleosis (glandular fever) and is strongly linked with the oncogenesis of several cancers, including B-cell lymphomas, nasopharyngeal, and gastric carcinomas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29718970/the-current-status-of-clinical-trials-focusing-on-nasopharyngeal-carcinoma-a-comprehensive-analysis-of-clinicaltrials-gov-database
#8
Hao Peng, Lei Chen, Yu-Pei Chen, Wen-Fei Li, Ling-Long Tang, Ai-Hua Lin, Ying Sun, Jun Ma
PURPOSE: Clinical Trials have emerged as the main force in driving the development of medicine. However, little is known about the current status of clinical trials regarding nasopharyngeal carcinoma (NPC). This study aimed at providing a comprehensive landscape of NPC-related trials on the basis of ClinicalTrials.gov database. PATIENTS AND METHODS: We used the keyword "nasopharyngeal carcinoma" to search the ClinicalTrials.gov database and assessed the characteristics of these trials...
2018: PloS One
https://www.readbyqxmd.com/read/29695622/bglf2-increases-infectivity-of-epstein-barr-virus-by-activating-ap-1-upon-de-novo-infection
#9
Natsuno Konishi, Yohei Narita, Fumiya Hijioka, H M Abdullah Al Masud, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata
Epstein-Barr virus (EBV) is a human gammaherpesvirus that causes infectious mononucleosis and several malignancies, such as endemic Burkitt lymphoma and nasopharyngeal carcinoma. Herpesviruses carry genes that can modify cell functions, including transcription and ubiquitination, thereby facilitating viral growth and survival in infected cells. Using a reporter screening system, we revealed the involvement of several EBV gene products in such processes. Of these, BGLF2 activated the AP-1 signaling pathway through phosphorylation of p38 and c-Jun N-terminal kinase (JNK)...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29692821/association-between-oral-lichen-planus-and-epstein-barr-virus-in-iranian-patients
#10
Matin Shariati, Mojgan Mokhtari, Aria Masoudifar
Background: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein-Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. Materials and Methods: The study was carried out on a case group including 38 tissue specimens of patients with histopathological confirmation of OLP and a control group including 38 samples of healthy mucosa...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29691341/epigenetic-regulation-of-tumor-suppressors-by-helicobacter-pylori-enhances-ebv-induced-proliferation-of-gastric-epithelial-cells
#11
Saurabh Pandey, Hem Chandra Jha, Sanket Kumar Shukla, Meghan K Shirley, Erle S Robertson
Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can establish lifelong persistent infection in the host. This leads to chronic inflammation, which also contributes to development of cancer. Association with H. pylori increases the risk of gastric carcinoma, and coexistence with EBV enhances proliferation of infected cells. Further, H. pylori -EBV coinfection causes chronic inflammation in pediatric patients. We have established an H. pylori -EBV coinfection model system using human gastric epithelial cells...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29688091/molecular-detection-of-hhv1-5-aav-and-hpv-in-semen-specimens-and-their-impact-on-male-fertility
#12
Emad Behboudi, Talat Mokhtari-Azad, Jila Yavarian, Nastaran Ghavami, Seyed Mahmood Seyed Khorrami, Farhad Rezaei, Javad Charostad, Somayeh Shatizadeh Malekshahi, Nazanin Zahra Shafiei-Jandaghi
Viral infections have been considered as possible destructive factors that influence male fertility. The aim of this study was to determine the prevalence of human herpes viruses 1-5 (HHV1-5), adeno associated virus (AAV) and human papilloma virus (HPV) in semen and whether these influence semen quality. DNA extraction was performed using phenol-chloroform protocol, then three different nested-PCRs were done to detect HHV1-5, AAV and HPV DNAs in the semen samples. Of 145 samples, 66 (45.5%) were positive at least for one of the viruses...
April 24, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29687211/dual-threat-of-epstein-barr-virus-an-autopsy-case-report-of-hiv-positive-plasmablastic-lymphoma-complicating-ebv-associated-hemophagocytic-lymphohistiocytosis
#13
Yusuke Koizumi, Ken-Ichi Imadome, Yasunori Ota, Hitoshi Minamiguchi, Yoshinori Kodama, Dai Watanabe, Hiroshige Mikamo, Tomoko Uehira, Seiji Okada, Takuma Shirasaka
Epstein-Barr virus (EBV) reactivation causes serious diseases in immunocompromised hosts, such as acquired immunodeficiency syndrome (AIDS). We report on a case of plasmablastic lymphoma (PBL) with hemophagocytic lymphohistiocytosis (HLH).A-53-year-old Japanese man was diagnosed with PBL and AIDS. In addition to combined antiretroviral therapy, HyperCVAD (cyclophosphamide, doxorubicin, vincristine, prednisone)/high-dose methotrexate + cytarabine was initiated immediately. Partial remission was attained with chemotherapy...
April 23, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29678144/interferon-alpha-as-antiviral-therapy-in-chronic-active-epstein-barr-virus-disease-with-interstitial-pneumonia-case-report
#14
Jacek Roliński, Ewelina Grywalska, Aleksandra Pyzik, Michał Dzik, Violetta Opoka-Winiarska, Agata Surdacka, Maciej Maj, Franciszek Burdan, Michał Pirożyński, Piotr Grabarczyk, Elżbieta Starosławska
BACKGROUND: Chronic active Epstein-Barr virus (EBV) disease (CAEBV) is defined as a severe, progressive lymphoproliferative disorder associated with active EBV infection persisting longer than 6 months and developing in patients without recognised immunodeficiency. Rarely, interstitial pneumonitis (IP) occurs as a serious complication in CAEBV patients. The standard therapeutic regimen for IP in CAEBV has not yet been defined. Although interferon alpha (IFN-alpha) is known to suppress viral DNA replication by affecting its basal promoter activation process, it is rarely used in CAEBV patients...
April 20, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29677384/risk-factors-and-long-term-outcomes-of-pediatric-liver-transplant-recipients-with-chronic-high-epstein-barr-virus-loads
#15
Hideya Kamei, Yoshinori Ito, Junichi Kawada, Satoshi Ogiso, Yasuharu Onishi, Masahiko Komagome, Nobuhiko Kurata, Yasuhiro Ogura
BACKGROUND: Serial monitoring of Epstein-Barr virus (EBV) reveals that certain pediatric liver transplant (LT) recipients exhibit high EBV loads for long periods. We investigated the incidence and risk factors of chronic high EBV (CHEBV) loads (continuous EBV DNA >10000 IU/mL of whole blood for ≥6 months) and long-term outcomes. METHODS: This single center, retrospective observational study investigated pediatric LT recipients who survived ≥6 months. We quantitated EBV DNA weekly during hospitalization and subsequently every 4 or 6 weeks at the outpatient clinic...
April 20, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29675003/role-of-micrornas-and-exosomes-in-helicobacter-pylori-and-epstein-barr-virus-associated-gastric-cancers
#16
REVIEW
Iva Polakovicova, Sofia Jerez, Ignacio A Wichmann, Alejandra Sandoval-Bórquez, Nicolás Carrasco-Véliz, Alejandro H Corvalán
Emerging evidence suggests that chronic inflammation caused by pathogen infection is connected to the development of various types of cancer. It is estimated that up to 20% of all cancer deaths is linked to infections and inflammation. In gastric cancer, such triggers can be infection of the gastric epithelium by either Helicobacter pylori ( H. pylori ), a bacterium present in half of the world population; or by Epstein-Barr virus (EBV), a double-stranded DNA virus which has recently been associated with gastric cancer...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29665370/conservation-and-polymorphism-of-ebv-rpms1-gene-in-ebv-associated-tumors-and-healthy-individuals-from-endemic-and-non-endemic-nasopharyngeal-carcinoma-areas-in-china
#17
Shuo Wu, Wen Liu, Hong Li, Zhenzhen Zhao, Yang Yang, Hua Xiao, Yingying Song, Bing Luo
As a member of the BamHI-A rightward transcripts family of the Epstein-Barr virus (EBV), RPMS1 expression has been confirmed in all EBV-associated tumors. However, few studies have investigated the single-nucleotide polymorphisms (SNPs) of RPMS1, and only one SNP site (g155391a) has been reported to be associated with nasopharyngeal carcinoma occurrence. The objective of this study was to investigate the polymorphism of RPMS1 in EBV-associated tumors (gastric carcinoma, nasopharyngeal carcinoma, and lymphoma)...
April 14, 2018: Virus Research
https://www.readbyqxmd.com/read/29664764/epstein-barr-virus-high-risk-human-papillomavirus-and-abnormal-cervical-cytology-in-a-prospective-cohort-of-african-female-sex-workers
#18
Jennifer E Cameron, Anne F Rositch, Nadja A Vielot, Nelly R Mugo, Jessie K L Kwatampora, Wairimu Waweru, Aubrey E Gilliland, Michael E Hagensee, Jennifer S Smith
BACKGROUND: High oncogenic-risk human papillomavirus (hrHPV) is necessary, although insufficient, to promote cervical cancer. Like HPV, Epstein-Barr virus (EBV) is a common pathogen with the capacity to promote epithelial neoplasms. We examined the association between cervical EBV, hrHPV, and cytology in female sex workers in Nairobi, Kenya. METHODS: Women (n=332) with known cervical cytology and hrHPV mRNA results were evaluated for cervical EBV DNA by conventional PCR...
April 17, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29653163/epstein-barr-virus-presence-as-a-potential-etiology-of-persistent-bladder-inflammation-in-human-interstitial-cystitis-bladder-pain-syndrome
#19
Jia-Fong Jhang, Yung-Hsiang Hsu, Chih-Wen Peng, Yuan-Hong Jiang, Han-Chen Ho, Hann-Chorng Kuo
PURPOSE: Interstitial cystitis/bladder pain syndrome is characterized by bladder inflammation without a bacterial infection. Although viral infection is a potential etiologic cause, few studies are reported. MATERIAL AND METHODS: Bladder specimens were obtained from patients with interstitial cystitis/bladder pain syndrome and patients with stress urinary incontinence (control). Bladder specimens were tested for Epstein-Barr-encoded RNAs by in situ hybridization, Epstein-Barr DNA by quantitative real-time polymerase chain reaction (qPCR), serology, and immunohistochemical staining...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29644247/quantification-of-torque-teno-virus-and-epstein-barr-virus-is-of-limited-value-for-predicting-the-net-state-of-immunosuppression-after-lung-transplantation
#20
Rickard Nordén, Jesper Magnusson, Anna Lundin, Ka-Wei Tang, Staffan Nilsson, Magnus Lindh, Lars-Magnus Andersson, Gerdt C Riise, Johan Westin
Background: Major hurdles for survival after lung transplantation are rejections and infectious complications. Adequate methods for monitoring immune suppression status are lacking. Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. Methods: This prospective single-center study included 98 patients followed for 2 years after transplantation...
April 2018: Open Forum Infectious Diseases
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