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https://www.readbyqxmd.com/read/30222230/l-aspariginase-aspiring-for-better-outcomes-in-endometrial-cancer
#1
Aditi Kishore Shinde
Newer molecular targets in endometrial cancer are perhaps the cause of differential chemotherapeutic response in similar histo-pathological subtypes. They regulate the ability of malignant cells to transform and give rise to chemo-resistant clones. L-aspargine is a protein substrate for tumor cells. This article is protected by copyright. All rights reserved.
September 17, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/30221739/distribution-and-prognostic-value-of-tumor%C3%A2-infiltrating-t-cells-in-breast-cancer
#2
Shaoda Meng, Li Li, Meiling Zhou, Wanjie Jiang, Heng Niu, Kunxian Yang
Tumor-infiltrating lymphocytes are associated with the response to neoadjuvent chemotherapy and prognosis in breast cancer. However, the distribution, interaction and prognostic value of tumor‑infiltrating T cells, the main component of the tumor microenvironment, have seldom been reported. In the present study, surgical specimens of 72 breast cancer patients were analyzed. Tumor‑infiltrating T cell subsets [cluster of differentiation (CD)4+T, CD8+T and regulatory T cells] and expression of their cytokines [interferon‑γ, interleukin (IL)‑4, and IL‑17] were evaluated by flow cytometry...
September 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30220972/the-frequency-of-promoter-dna-hypermethylation-is-decreased-in-colorectal-neoplasms-of-familial-adenomatous-polyposis
#3
Kiyoko Takane, Masaki Fukuyo, Keisuke Matsusaka, Satoshi Ota, Bahityar Rahmutulla, Kazuyuki Matsushita, Hideaki Miyauchi, Yukio Nakatani, Hisahiro Matsubara, Atsushi Kaneda
Familial adenomatous polyposis (FAP) is an inherited disorder characterized by numerous colorectal adenomatous polyps with predisposition to the development of colorectal cancer (CRC). Here, we conducted genome-wide DNA methylation analysis of FAP neoplasms, including seven cancer samples and 16 adenoma samples, using an Infinium 450K BeadArray. As controls for sporadic colorectal neoplasms and mucosae, we used Infinium 450k data from 297 CRC samples, 45 colorectal adenoma samples, and 37 normal mucosa samples with reference to The Cancer Genome Atlas and other databases...
August 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/30220319/three-distinct-genomic-subtypes-of-head-and-neck-squamous-cell-carcinoma-associated-with-clinical-outcomes
#4
Dong Jin Lee, Young-Gyu Eun, Young Soo Rho, Eui Hyun Kim, Sun Young Yim, Sang Hee Kang, Bo Hwa Sohn, Gee Hwan Kwon, Ju-Seog Lee
OBJECTIVES: Heterogeneity of head and neck squamous cell carcinomas (HNSCCs) results in unpredictable outcomes for patients with similar stages of cancer. Beyond the role of human papilloma virus (HPV), no validated molecular marker of HNSCCs has been established. Thus, clinically relevant molecular subtypes are needed to optimize HNSCC therapy. The purpose of this study was to identify subtypes of HNSCC that have distinct biological characteristics associated with clinical outcomes and to characterize genomic alterations that best reflect the biological and clinical characteristics of each subtype...
October 2018: Oral Oncology
https://www.readbyqxmd.com/read/30220117/-prognostic-significance-of-combined-tert-and-idh-gene-mutation-analysis-in-diffusely-infiltrating-gliomas
#5
Q Q Liu, X X Yin, Y Zou, T P Yu, J Gong, X Q Chen, L Nie, M Xu, M N Zhang, Q Zhou, N Chen
Objective: To investigate the status and prognostic significance of TERT and IDH1/2 genes mutations in diffusely infiltrating gliomas. Methods: Hot spot mutations of TERT and IDH1/2 genes were detected by DNA sequencing in 236 cases of gliomas at West China Hospital from 2012 to 2016, including pilocytic astrocytoma (WHO grade Ⅰ, 16 cases), diffuse astrocytoma and oligodendroglioma (WHO grade Ⅱ, 89 cases), anaplastic astrocytoma and oligodendroglioma (WHO grade Ⅲ, 72 cases) and glioblastoma (WHO grade Ⅳ, 59 cases)...
September 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/30219837/lncsldb-a-resource-for-long-non-coding-rna-subcellular-localization
#6
Xiao Wen, Lin Gao, Xingli Guo, Xing Li, Xiaotai Huang, Ying Wang, Haifu Xu, Ruijie He, Chenglong Jia, Feixiang Liang
While long non-coding RNAs (lncRNAs) may play important roles in cellular function and biological process, we still know little about them. Growing evidences indicate that subcellular localization of lncRNAs may provide clues to their functionality. To facilitate researchers functionally characterize thousands of lncRNAs, we developed a database-driven application, lncSLdb, which stores and manages user-collected qualitative and quantitative subcellular localization information of lncRNAs from literature mining...
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/30219829/longitudinal-study-of-esbl-escherichia-coli-carriage-on-an-organic-broiler-farm
#7
Angela H A M van Hoek, Christiaan Veenman, Alice Florijn, Patricia M C Huijbers, Elisabeth A M Graat, Sabine de Greeff, Cindy M Dierikx, Engeline van Duijkeren
Objectives: To determine the molecular characteristics of ESBL-producing Escherichia coli (ESBL-E) collected during a longitudinal study on an organic broiler farm in order to investigate clonal expansion and horizontal gene transfer. Methods: Isolates were obtained from a longitudinal study performed previously on an organic broiler fattening farm. Samples from individually followed-up broilers, the broiler house, the transport van and persons that took the samples, taken at several timepoints (days 1, 3, 4, 7, 10, 42 and 70) within a production round and during the consecutive one (days 1, 2, 3 and 70), had been investigated for the occurrence of ESBL-E...
September 14, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30219650/differing-clinical-features-between-japanese-and-caucasian-patients-with-myelodysplastic-syndromes-analysis-from-the-international-working-group-for-prognosis-of-mds
#8
Yasushi Miyazaki, Heinz Tuechler, Guillermo Sanz, Julie Schanz, Guillermo Garcia-Manero, Francesc Solé, John M Bennett, David Bowen, Pierre Fenaux, Francois Dreyfus, Hagop Kantarjian, Andrea Kuendgen, Luca Malcovati, Mario Cazzola, Jaroslav Cermak, Christa Fonatsch, Michelle M Le Beau, Marilyn L Slovak, Valeria Santini, Michael Lübbert, Jaroslaw Maciejewski, Sigrid Machherndl-Spandl, Silvia M M Magalhaes, Michael Pfeilstöcker, Mikkael A Sekeres, Wolfgang R Sperr, Reinhard Stauder, Sudhir Tauro, Peter Valent, Teresa Vallespi, Arjan A van de Loosdrecht, Ulrich Germing, Detlef Haase, Peter L Greenberg
Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/USA countries. In this study, to elucidate potential differences in primary untreated MDS between Japanese (JPN) and Caucasians (CAUC), we analyzed the data from a large international database collected by the International Working Group for Prognosis of MDS (300 and 5838 patients, respectively)...
September 6, 2018: Leukemia Research
https://www.readbyqxmd.com/read/30219480/demethylation-of-itgav-accelerates-osteogenic-differentiation-in-a-blast-induced-heterotopic-ossification-in-vitro-cell-culture-model
#9
Niall J Logan, Marie Camman, Greg Williams, Claire A Higgins
Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified model to evaluate the molecular events involved in heterotopic ossification onset that arise from the shock wave component of the disease. We exposed three subtypes of human mesenchymal cells in vitro to a single, high-energy shock wave and observed increased transcription in the osteogenic master regulators, Runx2 and Dlx5, and significantly accelerated cell mineralisation...
September 13, 2018: Bone
https://www.readbyqxmd.com/read/30218391/molecular-pathways-in-melanomagenesis-what-we-learned-from-next-generation-sequencing-approaches
#10
REVIEW
Giuseppe Palmieri, Maria Colombino, Milena Casula, Antonella Manca, Mario Mandalà, Antonio Cossu
PURPOSE OF REVIEW: Conventional clinico-pathological features in melanoma patients should be integrated with new molecular diagnostic, predictive, and prognostic factors coming from the expanding genomic profiles. Cutaneous melanoma (CM), even differing in biological behavior according to sun-exposure levels on the skin areas where it arises, is molecularly heterogeneous. The next-generation sequencing (NGS) approaches are providing data on mutation landscapes in driver genes that may account for distinct pathogenetic mechanisms and pathways...
September 14, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/30218308/siu-icud-on-bladder-cancer-pathology
#11
Eva Compérat, Marek Babjuk, Ferran Algaba, Mahul Amin, Fadi Brimo, David Grignon, Donna Hansel, Ondra Hes, Bernard Malavaud, Victor Reuter, Theo van der Kwast
Many changes have been made during these last years and concepts for understanding bladder cancer have evolved. We make an update with the latest findings of the WHO (World Health Organistaion) 2016, ICCR (International Collaboration on Cancer Reporting) and other official organisms and try to show the latest developments. In this document we provide new consensus guidelines and insights. We kept this document short and concise providing consensus guidelines to clinicians for the best patient care, it should be easy to understand for a non pathologists...
September 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30218307/the-role-of-biomarkers-in-bladder-preservation-management-of-muscle-invasive-bladder-cancer
#12
Timur Mitin, Ananya Choudhury
PURPOSE: Patients with localized muscle-invasive bladder cancer (MIBC) can choose to undergo either neoadjuvant chemotherapy followed by radical cystectomy or radiation therapy-based bladder preservation treatment modality with subsequent close cystoscopic surveillance with salvage cystectomy reserved for patients with evidence of local disease recurrence. At the present time, the decision regarding bladder-directed local therapy for MIBC is based on physicians' and patients' preferences, and does not take into account tumor biology...
September 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30217369/genomics-to-immunotherapy-of-ovarian-clear-cell-carcinoma-unique-opportunities-for-management
#13
REVIEW
Katsutoshi Oda, Junzo Hamanishi, Koji Matsuo, Kosei Hasegawa
Ovarian clear cell carcinoma (OCCC) is distinctive from other histological types of epithelial ovarian cancer, with genetic/epigenetic alterations, a specific immune-related molecular profile, and epidemiologic associations with ethnicity and endometriosis. These findings allow for the exploration of unique and specific treatments for OCCC. Two major mutated genes in OCCC are PIK3CA and ARID1A, which are frequently coexistent with each other. Other genes' alterations also contribute to activation of the PI3K (e...
September 11, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30217070/variability-of-botulinum-toxins-challenges-and-opportunities-for-the-future
#14
REVIEW
Christine Rasetti-Escargueil, Emmanuel Lemichez, Michel R Popoff
Botulinum neurotoxins (BoNTs) are the most potent known toxins, and are therefore classified as extremely harmful biological weapons. However, BoNTs are therapeutic drugs that are widely used and have an increasing number of applications. BoNTs show a high diversity and are divided into multiple types and subtypes. Better understanding of the activity at the molecular and clinical levels of the natural BoNT variants as well as the development of BoNT-based chimeric molecules opens the door to novel medical applications such as silencing the sensory neurons at targeted areas and dermal restoration...
September 13, 2018: Toxins
https://www.readbyqxmd.com/read/30216798/bortezomib-inhibited-the-progression-of-diffuse-large-b-cell-lymphoma-via-targeting-mir-198
#15
Ruihuan Wang, Jie Shen, Qing Wang, Minjuan Zhang
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, which is an aggressive malignancy with high variance of clinical features and response to the treatment. The proteasome inhibitor bortezomib (BTZ) has been demonstrated to suppress the progression of DLBCL, however, the underlying molecular mechanisms by which BTZ regulates the growth of DLBCL cells remain largely unknown. Increasing evidence has suggested that microRNAs (miRNAs) are novel targets of anti-cancer drugs to modulate the progression of cancers...
September 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30216501/foxo1-associated-with-sensitivity-to-chemotherapy-drugs-and-glial-mesenchymal-transition-in-glioma
#16
Chao Chen, Guosheng Han, Yanan Li, Zhijian Yue, Laixing Wang, Jianmin Liu
Mesenchymal subtype of glioblastoma (GBM), identified as one of four clinically relevant molecular subtypes, has worst prognosis because of its close relation with the malignant biological properties induced by glial-mesenchymal transition (GMT). However, the molecular mechanism of GMT and its characterized molecule of GBM have not been studied. Forkhead box protein O1 (FOXO1) is at a convergence point of receptor tyrosine kinase signaling as one of the three core pathways implicated in GBM. Our previous study indicated that the inactivation of FOXO1 involved in the inhibition of GMT is an independent prognosis factor of GBM...
September 14, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30216380/dissecting-cancer-heterogeneity-based-on-dimension-reduction-of-transcriptomic-profiles-using-extreme-learning-machines
#17
Kejun Wang, Xin Duan, Feng Gao, Wei Wang, Liangliang Liu, Xin Wang
It is becoming increasingly clear that major malignancies such as breast, colorectal and gastric cancers are not single disease entities, but comprising multiple cancer subtypes of distinct molecular properties. Molecular subtyping has been widely used to dissect inter-tumor biological heterogeneity, in relation to clinical outcomes. A key step of this methodology is to perform unsupervised classification of gene expression profiles, which, however, often suffers challenges of high-dimensionality, feature redundancy as well as noise and irrelevant information...
2018: PloS One
https://www.readbyqxmd.com/read/30215581/identifying-a-new-subtype-of-multiple-sclerosis
#18
Bruce D Trapp, Daniel Ontaneda
Dr Bruce Trapp and Dr Daniel Ontaneda speak to Laura Dormer, Commissioning Editor: Bruce D Trapp, PhD, is a Chair of the Department of Neurosciences at the Lerner Research Institute, Cleveland Clinic (OH, USA) and Professor of Molecular Medicine at Case Western Reserve University (OH, USA). Dr Trapp received his PhD from Loyola University Stritch School of Medicine in Chicago (IL, USA). Dr Trapp's research investigates the cause of neurological disability in multiple sclerosis patients, cellular mechanism of brain repair in neurodegenerative diseases and the molecular biology of myelination in the central and peripheral nervous systems...
September 14, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/30215118/-molecular-predictors-in-immune-oncology
#19
REVIEW
W Weichert
The current rapid development of novel therapeutic approaches in immune oncology (IO) and specifically in the field of immune checkpoint inhibition is accompanied by an equally dynamic development of novel biomarker approaches for the identification of responding/non-responding patients under IO treatment. In addition to the measurement of the expression of checkpoint ligands/receptors, complex molecular predictors are gaining increasing attention in certain IO treatment constellations. This includes the entity informed identification of molecularly defined biological tumor subtypes (e...
September 13, 2018: Der Pathologe
https://www.readbyqxmd.com/read/30214726/immunoexpression-of-claudins-4-and-7-among-invasive-breast-carcinoma-subtypes-a-large-diagnostic-study-using-tissue-microarray
#20
Angela Flávia Logullo, Fatima Solange Pasini, Suely Nonogaki, Rafael Malagoli Rocha, Fernando Augusto Soares, Maria Mitzi Brentani
Molecular phenotyping and tissue microarray (TMA) studies have identified distinct invasive breast carcinoma subtypes: Luminal A, luminal B, enriched with overexpressed human epidermal growth factor receptor 2 (HER-2) and triple-negative, i.e., negative for HER-2, as well as for estrogen and progesterone receptor (ER and PR, respectively) expression. These subtypes are useful in clinical management, since they bear distinct prognoses and predictive responses to targeted therapy. However, although molecular profiling provides important prognostic indicators, breast cancer risk stratification remains a challenge in triple-negative cases...
October 2018: Molecular and Clinical Oncology
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