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https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#1
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166494/sporotrichosis-an-update-on-epidemiology-etiopathogenesis-laboratory-and-clinical-therapeutics
#2
Rosane Orofino-Costa, Priscila Marques de Macedo, Anderson Messias Rodrigues, Andréa Reis Bernardes-Engemann
In the late 90's there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. In addition to becoming hyperendemic, uncommon clinical pictures like immunoreactive clinical presentations or severe systemic cases have emerged. New species were identified and classified through molecular tools using more virulent clinical isolates, like S...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29165853/past-year-prescription-drug-monitoring-program-opioid-prescriptions-and-self-reported-opioid-use-in-an-emergency-department-population-with-opioid-use-disorder
#3
Kathryn Hawk, Gail D'Onofrio, David A Fiellin, Marek C Chawarski, Patrick G O'Connor, Patricia H Owens, Michael V Pantalon, Steven L Bernstein
BACKGROUND: Despite increasing reliance on Prescription Drug Monitoring Programs (PDMPs) as a response to the opioid epidemic, the relationship between aberrant drug-related behaviors captured by the PDMP and opioid use disorder is incompletely understood. How PDMP data should guide Emergency Department (ED) assessment has not been studied. STUDY OBJECTIVE: To evaluate a relationship between PDMP opioid prescription records and self-reported non-medical opioid use of prescription opioids in a cohort of opioid dependent ED patients enrolled in a treatment trial...
November 22, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29165624/cost-and-potential-avoidability-of-antibiotic-associated-adverse-drug-reactions-in-children
#4
Julie N Beck, Sarah L Suppes, Claire R Smith, Brian R Lee, J Steven Leeder, Michelle VanDoren, Jason G Newland, Jennifer L Goldman
We identified 375 children who visited the emergency department or urgent care clinic at Children's Mercy Hospitals & Clinics for antibiotic adverse drug reactions over a 1-year period, and the total cost for these visits was $170 893.20. Of these ADRs, 17% were likely avoidable. The potential negative consequences of antibiotics should be considered at the point of prescribing.
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29165621/treatment-of-tuberculosis-in-complex-emergencies-in-developing-countries-a-scoping-review
#5
Geraldine Munn-Mace, Divya Parmar
Almost 172 million people live in complex emergencies globally resulting from political and/or economic instability. The provision and continuity of health care in complex emergencies remain a significant challenge. Health agencies are often hesitant to implement tuberculosis programmes in particular because its treatment requires a longer commitment than most acute diseases. However, not treating tuberculosis promptly increases mortality and untreated tuberculosis further increases the incidence of tuberculosis...
November 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29165360/dynamic-docking-a-paradigm-shift-in-computational-drug-discovery
#6
REVIEW
Dario Gioia, Martina Bertazzo, Maurizio Recanatini, Matteo Masetti, Andrea Cavalli
Molecular docking is the methodology of choice for studying in silico protein-ligand binding and for prioritizing compounds to discover new lead candidates. Traditional docking simulations suffer from major limitations, mostly related to the static or semi-flexible treatment of ligands and targets. They also neglect solvation and entropic effects, which strongly limits their predictive power. During the last decade, methods based on full atomistic molecular dynamics (MD) have emerged as a valid alternative for simulating macromolecular complexes...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29165080/tuberculosis-treated-by-multiple-drugs-an-overview
#7
Gyanendra Singh, Prashant Kesharwani, A K Shrivastava
Current tuberculosis (TB) treatment is established on an amalgamation of drugs that were evolved mostly in the central decades of the hind century. Cure rates are elevated for drug-sensitive strains of Mycobacterium tuberculosis (M.Tb) when the recommended complex and prolonged treatment protocols adhere. However, the difficulty in accurately prescribing and adhering to these protocols and the emergence of M. Tb strains resistant to multiple drugs and drug-drug interactions that interfere with optimal treatment of Tuberculosis and co-infected patients with the different disease has generated a pressing need for improved Tuberculosis therapies...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29165071/minocycline-loaded-in-situ-hydrogel-for-periodontitis-treatment
#8
Xiaoqing Wang, Jianli Ma, Xiaoming Zhu, Fang Wang, Liang Zhou
In situ hydrogel based on phase separation by solvent exchange has emerged as an attractive alternative for periodontal pocket injection. In this study, an minocycline (MCL)-loaded in situ hydrogel was prepared composed of poly(lactide-co-glycolide) (PLGA) and N-methylpyrrolidone (NMP) to enhance the topical treatment of periodontitis. A series of reasonable and applicable formulations were optimized by investigating their syringeability, viscosity and in vitro drug release. The rheological profiles, antimicrobial activities and pharmacodynamics were further studied to evaluate its effect on periodontitis treatment...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164901/co-amorphous-formation-of-high-dose-zwitterionic-compounds-with-amino-acids-to-improve-solubility-and-enable-parenteral-delivery
#9
Saijie Zhu, Huisheng Gao, Sreehari Babu, Sudhakar Garad
Solubilization of parenteral drugs is a high unmet need in both pre-clinical and clinical drug development. Recently, co-amorphous drug formulation has emerged as a new strategy to solubilize orally dosed drugs. The aim of the present study is to explore the feasibility of using the co-amorphous strategy to enable the dosing of parenteral zwitterionic drugs at a high concentration. A new screening procedure was established with solubility as the indicator for co-amorphous co-former selection, and lyophilization was established as the method for co-amorphous formulation preparation...
November 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29164804/biomaterials-and-advanced-technologies-for-hemostatic-management-of-bleeding
#10
REVIEW
DaShawn A Hickman, Christa L Pawlowski, Ujjal D S Sekhon, Joyann Marks, Anirban Sen Gupta
Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders...
November 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29164599/neurocognition-and-subjective-experience-following-acute-doses-of-the-synthetic-cannabinoid-jwh-018-a-phase-1-placebo-controlled-pilot-study
#11
Eef L Theunissen, Nadia R P W Hutten, Natasha L Mason, Stefan W Toennes, Kim P C Kuypers, Eliza B de Sousa Fernandes Perna, Johannes G Ramaekers
BACKGROUND AND PURPOSE: Synthetic cannabinoids (often sold as Spice or K2) have become a very popular alternative to cannabis due to the easy access and portrayed safety. Controlled studies on the behavioral effects of synthetic cannabinoids are currently lacking, which hampers risk assessments of these compounds. EXPERIMENTAL APPROACH: This is a first attempt to assess the influence of a synthetic cannabinoid, JWH-018, on neurocognition and subjective experience in humans after controlled administration...
November 22, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29164196/supramolecular-polymeric-biomaterials
#12
REVIEW
Joseph L Mann, Anthony C Yu, Gillie Agmon, Eric A Appel
Polymeric chains crosslinked through supramolecular interactions-directional and reversible non-covalent interactions-compose an emerging class of modular and tunable biomaterials. The choice of chemical moiety utilized in the crosslink affords different thermodynamic and kinetic parameters of association, which in turn illustrate the connectivity and dynamics of the system. These parameters, coupled with the choice of polymeric architecture, can then be engineered to control environmental responsiveness, viscoelasticity, and cargo diffusion profiles, yielding advanced biomaterials which demonstrate rapid shear-thinning, self-healing, and extended release...
November 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29164150/potential-anticancer-mechanisms-of-a-novel-egfr-dna-targeting-combi-molecule-jdf12-against-du145-prostate-cancer-cells-an-itraq-based-proteomic-analysis
#13
Haofeng Zheng, Guancan Liang, Yanxiong Chen, Sijie Lin, Wei Liu, Youqiang Fang
The development of multitargeting drugs is an emerging trend in cancer research. To promote further development and clinical application of multitargeting drugs, this research was performed. MTT assay and flow cytometry of Annexin V/propidium iodide staining were used to confirm the proapoptotic efficacy of a novel combi-targeting molecule, JDF12, against DU145 prostate cancer (PCa) cells. Differentially expressed proteins between control and JDF12-treated cultures were revealed by isobaric tags for relative and absolute quantitation (iTRAQ), and part of them was confirmed by quantitative PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29164104/targeting-dengue-virus-ns-3-helicase-by-ligand-based-pharmacophore-modeling-and-structure-based-virtual-screening
#14
Sobia A Halim, Shanza Khan, Ajmal Khan, Abdul Wadood, Fazal Mabood, Javid Hussain, Ahmed Al-Harrasi
Dengue fever is an emerging public health concern, with several million viral infections occur annually, for which no effective therapy currently exist. Non-structural protein 3 (NS-3) Helicase encoded by the dengue virus (DENV) is considered as a potential drug target to design new and effective drugs against dengue. Helicase is involved in unwinding of dengue RNA. This study was conducted to design new NS-3 Helicase inhibitor by in silico ligand- and structure based approaches. Initially ligand-based pharmacophore model was generated that was used to screen a set of 1201474 compounds collected from ZINC Database...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29164055/micrornas-and-acute-myeloid-leukemia-chemoresistance-a-mechanistic-overview
#15
REVIEW
Martino Marco Gabra, Leonardo Salmena
Up until the early 2000s, a functional role for microRNAs (miRNAs) was yet to be elucidated. With the advent of increasingly high-throughput and precise RNA-sequencing techniques within the last two decades, it has become well established that miRNAs can regulate almost all cellular processes through their ability to post-transcriptionally regulate a majority of protein-coding genes and countless other non-coding genes. In cancer, miRNAs have been demonstrated to play critical roles by modifying or controlling all major hallmarks including cell division, self-renewal, invasion, and DNA damage among others...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29163776/mir-1268b-confers-chemosensitivity-in-breast-cancer-by-targeting-erbb2-mediated-pi3k-akt-pathway
#16
Wen-Jie Zhu, Xu Chen, Ya-Wen Wang, Hai-Ting Liu, Ran-Ran Ma, Peng Gao
Chemoresistance represents a major obstacle to effective therapy for breast cancer. Emerging evidences associated aberrantly expressed miRNAs with tumor development and chemoresistance. MiR-1268b has never been studied in any cancers before, and its roles in mediating tumor progression and drug resistance are still unclear. Selected from miRNA microarray and confirmed by real-time quantitative PCR (RT-qPCR), miR-1268b was found to be significantly upregulated in drug sensitive and ERBB2 negative tissues, as well as in breast cancer patients with low clinical stage...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163732/a-comparison-of-the-effects-and-side-effects-of-oral-betahistine-with-injectable-promethazine-in-the-treatment-of-acute-peripheral-vertigo-in-emergency
#17
Hassan Motamed, Meisam Moezzi, Ali Dalir Rooyfard, Kambiz Ahmadi Angali, Zahra Izadi
Background: Vertigo is an illusion of rotation that is caused by the asymmetry of neurological function of the right and left vestibular nuclei. The aim of this study was to compare the efficacy and side effects of oral betahistine with injectable promethazine in treatment of acute peripheral vertigo. Methods: In this double-blind clinical trial study, the patients with acute peripheral vertigo were assigned in the two groups: receiving promethazine intramuscularly at a dose of 25 mg (group A) and receiving 8 mg betahistine tablets (group B) and the severity of their vertigo was evaluated on the visual analog scale (VAS) scoring system...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163551/host-antimicrobial-peptides-the-promise-of-new-treatment-strategies-against-tuberculosis
#18
REVIEW
Javier Arranz-Trullén, Lu Lu, David Pulido, Sanjib Bhakta, Ester Boix
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163516/restoring-natural-killer-cell-immunity-against-multiple-myeloma-in-the-era-of-new-drugs
#19
REVIEW
Gianfranco Pittari, Luca Vago, Moreno Festuccia, Chiara Bonini, Deena Mudawi, Luisa Giaccone, Benedetto Bruno
Transformed plasma cells in multiple myeloma (MM) are susceptible to natural killer (NK) cell-mediated killing via engagement of tumor ligands for NK activating receptors or "missing-self" recognition. Similar to other cancers, MM targets may elude NK cell immunosurveillance by reprogramming tumor microenvironment and editing cell surface antigen repertoire. Along disease continuum, these effects collectively result in a progressive decline of NK cell immunity, a phenomenon increasingly recognized as a critical determinant of MM progression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163441/antifungal-and-anti-biofilm-activity-of-essential-oil-active-components-against-cryptococcus-neoformans-and-cryptococcus-laurentii
#20
Poonam Kumari, Rutusmita Mishra, Neha Arora, Apurva Chatrath, Rashmi Gangwar, Partha Roy, Ramasare Prasad
Cryptococcosis is an emerging and recalcitrant systemic infection occurring in immunocompromised patients. This invasive fungal infection is difficult to treat due to the ability of Cryptococcus neoformans and Cryptococcus laurentii to form biofilms resistant to standard antifungal treatment. The toxicity concern of these drugs has stimulated the search for natural therapeutic alternatives. Essential oil and their active components (EO-ACs) have shown to possess the variety of biological and pharmacological properties...
2017: Frontiers in Microbiology
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